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chr14:22,670,975-25,605,046

Best TWAS P=7.11e-79 · Best GWAS P=4.01e-169 conditioned to 2.87e-34

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A17	0.21	0.05	lasso	4	0.07	1.1e-04	21.030	18.8	7.1e-79	0.44	0.32	0.32	TRUE
11	GTEx	Colon Sigmoid	HOMEZ	0.24	-0.01	lasso	4	-0.01	9.6e-01	21.839	-17.6	3.7e-69	-0.50	0.06	0.30	TRUE
48	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CMTM5	0.15	0.06	lasso	4	0.05	9.0e-03	6.668	-15.3	1.5e-52	-0.48	0.02	0.26	TRUE
12	GTEx	Colon Transverse	RBM23	0.31	0.05	lasso	4	0.10	2.0e-05	2.558	9.9	2.9e-23	0.23	0.16	0.05	TRUE
50	The Cancer Genome Atlas	Thyroid Carcinoma	NGDN	0.05	0.03	enet	9	0.02	5.9e-03	4.650	9.8	1.5e-22	0.24	0.02	0.15	TRUE
35	METSIM	Adipose	SLC7A8	0.07	0.00	blup	492	0.02	4.2e-04	1.083	9.2	5.5e-20	0.14	0.09	0.07	TRUE
14	GTEx	Colon Transverse	RP11-66N24.4	0.36	0.11	lasso	7	0.06	7.1e-04	5.483	8.3	7.4e-17	0.02	0.14	0.09	TRUE
49	The Cancer Genome Atlas	Testicular Germ Cell Tumors	THTPA	0.12	0.01	blup	62	0.04	1.2e-02	8.055	-8.3	9.8e-17	-0.06	0.02	0.17	TRUE
27	GTEx	Skin Sun Exposed Lower leg	NGDN	0.09	0.02	lasso	3	0.01	9.2e-02	8.044	-7.0	2.8e-12	-0.02	0.41	0.02	TRUE
34	METSIM	Adipose	SLC22A17	0.09	0.09	bslmm	438	0.09	9.0e-13	6.214	6.7	2.9e-11	0.19	1.00	0.00	TRUE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	CBLN3	0.27	0.12	enet	12	0.16	2.9e-17	-5.367	6.6	5.4e-11	0.03	0.10	0.90	TRUE
29	GTEx	Testis	PSMB5	0.30	0.01	enet	23	0.09	1.3e-04	-0.077	5.5	4.0e-08	0.20	0.08	0.14	TRUE
33	METSIM	Adipose	PPP1R3E	0.07	0.00	blup	462	0.02	5.3e-04	6.684	15.3	9.4e-53	0.44	0.04	0.59	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EFS	0.05	0.04	lasso	2	0.03	1.1e-04	11.040	-11.3	1.4e-29	-0.18	0.14	0.03	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	RBM23	0.28	0.00	enet	32	0.04	1.7e-02	-0.166	11.1	7.9e-29	0.32	0.05	0.42	FALSE
31	METSIM	Adipose	CDH24	0.04	0.00	bslmm	524	0.01	1.7e-02	-2.226	8.1	6.3e-16	0.22	0.06	0.04	FALSE
15	GTEx	Colon Transverse	AP1G2	0.39	0.03	lasso	7	0.09	3.2e-05	5.483	6.7	2.8e-11	-0.03	0.14	0.07	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CBLN3	0.43	0.22	enet	31	0.35	3.4e-44	-5.367	6.4	1.4e-10	0.01	0.12	0.88	FALSE
5	GTEx	Artery Aorta	KHNYN	0.19	0.20	lasso	4	0.20	1.8e-11	-6.135	-6.3	2.4e-10	-0.06	0.00	1.00	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	HAUS4	0.37	0.24	enet	22	0.24	3.7e-09	0.797	-6.2	5.1e-10	-0.19	0.99	0.00	FALSE
21	GTEx	Lung	KHNYN	0.14	0.08	lasso	5	0.05	9.7e-05	-5.983	-6.2	5.8e-10	-0.05	0.00	1.00	FALSE
23	GTEx	Nerve Tibial	KHNYN	0.34	0.10	lasso	8	0.15	1.6e-10	-5.983	-6.2	7.0e-10	-0.04	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	KHNYN	0.30	0.14	lasso	2	0.14	7.1e-12	-5.453	-6.1	9.8e-10	-0.03	0.04	0.96	FALSE
10	GTEx	Breast Mammary Tissue (Female)	CBLN3	0.42	0.20	lasso	4	0.28	5.9e-09	-5.074	6.0	2.1e-09	0.04	0.02	0.98	FALSE
30	GTEx	Whole Blood	KHNYN	0.17	0.15	lasso	1	0.14	2.1e-12	-5.983	-6.0	2.2e-09	-0.05	0.00	1.00	FALSE
32	METSIM	Adipose	KHNYN	0.04	0.04	lasso	1	0.03	2.2e-05	-5.983	-6.0	2.2e-09	-0.05	0.00	0.99	FALSE
37	YFS	Blood	KHNYN	0.36	0.20	enet	50	0.29	1.2e-96	-6.135	-6.0	2.5e-09	-0.02	0.00	1.00	FALSE
7	GTEx	Artery Tibial	KHNYN	0.38	0.12	lasso	5	0.18	8.8e-14	-5.983	-5.9	3.1e-09	-0.04	0.00	1.00	FALSE
18	GTEx	Esophagus Muscularis	CBLN3	0.62	0.33	enet	23	0.36	1.8e-22	-5.453	5.9	4.4e-09	0.01	0.10	0.90	FALSE
9	GTEx	Breast Mammary Tissue (Male)	CBLN3	0.67	0.25	enet	18	0.32	4.0e-08	-5.115	5.8	7.0e-09	0.01	0.03	0.95	FALSE
3	GTEx	Adipose Visceral Omentum	KHNYN	0.19	0.00	lasso	2	0.00	3.0e-01	-5.983	-5.7	9.7e-09	-0.05	0.03	0.50	FALSE
36	NTR	Blood	KHNYN	0.07	0.06	bslmm	564	0.06	6.6e-19	-6.135	-5.7	1.1e-08	-0.07	0.00	1.00	FALSE
22	GTEx	Muscle Skeletal	CBLN3	0.14	0.13	enet	7	0.13	4.8e-13	-5.367	5.6	2.3e-08	0.03	0.13	0.87	FALSE
44	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CBLN3	0.37	0.35	lasso	4	0.34	4.4e-15	-5.453	5.5	3.0e-08	0.03	0.11	0.89	FALSE
6	GTEx	Artery Aorta	CBLN3	0.55	0.41	lasso	8	0.40	9.5e-24	-5.115	5.5	3.1e-08	0.01	0.17	0.83	FALSE
20	GTEx	Heart Left Ventricle	CBLN3	0.35	0.23	lasso	8	0.21	1.5e-11	-5.453	5.5	3.4e-08	0.01	0.12	0.88	FALSE
45	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HOMEZ	0.19	0.01	blup	41	0.05	6.0e-03	4.382	5.4	5.2e-08	0.21	0.01	0.39	FALSE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CBLN3	0.21	0.18	lasso	3	0.19	8.2e-16	-5.367	5.4	6.6e-08	0.02	0.12	0.88	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	CBLN3	0.20	0.18	lasso	3	0.18	5.0e-36	-5.367	5.4	7.6e-08	0.02	0.11	0.89	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	CBLN3	0.30	0.26	lasso	1	0.24	1.4e-17	-5.367	5.4	8.0e-08	0.02	0.12	0.88	FALSE
19	GTEx	Heart Atrial Appendage	CBLN3	0.58	0.40	lasso	5	0.38	2.3e-18	-5.453	5.3	9.0e-08	0.01	0.11	0.89	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	CBLN3	0.24	0.14	enet	8	0.13	4.0e-08	-5.074	5.3	1.1e-07	0.01	0.14	0.86	FALSE
13	GTEx	Colon Transverse	CBLN3	0.46	0.31	lasso	6	0.34	5.3e-17	-5.453	5.3	1.3e-07	0.00	0.11	0.89	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CBLN3	0.49	0.36	lasso	7	0.36	1.3e-21	-5.367	5.3	1.3e-07	0.02	0.13	0.87	FALSE
28	GTEx	Skin Sun Exposed Lower leg	CBLN3	0.47	0.32	enet	21	0.32	2.6e-27	-5.115	5.3	1.4e-07	0.02	0.23	0.77	FALSE
8	GTEx	Breast Mammary Tissue	CBLN3	0.53	0.29	lasso	12	0.30	5.0e-16	-5.115	5.2	1.6e-07	0.01	0.18	0.82	FALSE
4	GTEx	Adipose Visceral Omentum	CBLN3	0.27	0.23	enet	15	0.23	2.6e-12	-5.453	5.2	1.7e-07	0.00	0.12	0.88	FALSE
24	GTEx	Nerve Tibial	CBLN3	0.71	0.35	enet	18	0.36	1.9e-26	-5.115	5.2	2.4e-07	0.02	0.20	0.80	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	CBLN3	0.41	0.34	lasso	2	0.30	3.4e-17	-5.115	5.1	2.7e-07	0.01	0.18	0.82	FALSE
46	The Cancer Genome Atlas	Soft Tissue Sarcoma	CBLN3	0.22	0.18	lasso	3	0.17	2.2e-10	-5.115	5.1	2.7e-07	0.01	0.27	0.73	FALSE