TWAS hub - CDH24

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.3164	0.0800	0.00043	0.146	NA	0.170	NA	0.006	3.5e-08	NA	2.2e-09	NA	0.150
2	GTEx	Skin Not Sun Exposed Suprapubic	0.2780	0.0880	0.00490	0.006	NA	0.008	NA	0.010	1.5e-01	NA	1.1e-01	NA	0.091
3	METSIM	Adipose	0.0407	0.0196	0.02000	-0.001	0.008	0.002	0.008	0.008	4.3e-01	0.017	1.4e-01	0.017	0.018

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pulse rate, automated reading	7.0	22.7	65.3	-1.7	-0.2	8.1
Townsend deprivation index at recruitment	5.8	8.2	10.5	-2.6	2.7	3.2
Prostate Cancer	5.6	7.9	14.5	3.0	-0.6	3.8
Average weekly red wine intake	4.5	6.7	14.7	-1.9	-1.4	-3.8
Exposure to tobacco smoke at home	3.3	3.7	8.1	0.0	2.9	1.7
Pulse rate	3.2	5.4	12.9	-1.7	-0.7	3.6
Mouth/teeth dental problems	3.1	4.8	8.7	-0.1	-2.4	-3.0
Loneliness, isolation	2.9	4.0	7.8	-2.0	2.8	0.5
Medication: Gliclazide	2.8	3.2	5.6	1.8	-0.8	2.4
Leg pain on walking	2.7	3.4	5.4	-2.3	2.1	-0.5
Ever used hormone-replacement therapy (HRT)	2.6	3.3	4.6	-2.1	1.0	-2.1
Qualifications: None of the above	2.6	5.5	8.6	0.8	2.7	2.9
Headache pain in last month	2.3	4.0	6.7	1.4	1.8	2.6
Depression (Nagel 2018)	2.2	3.3	6.9	-1.8	2.6	0.2
Supplements: Zinc	2.2	2.4	5.5	-2.3	1.3	-0.3
Breastfed as a baby	2.1	2.6	3.7	-1.9	-1.7	-1.2
Average weekly spirits intake	2.0	2.5	7.2	-2.7	0.4	0.3
Chronic bronchitis/emphysema (mother)	2.0	2.3	4.5	2.1	0.2	1.6
Worry too long after embarrassment	2.0	3.4	5.7	-1.4	-2.4	-1.6
LDL Cholesterol	1.9	3.0	8.8	0.0	3.0	-0.4
Chronic bronchitis/emphysema (father)	1.9	2.2	3.2	-1.0	1.6	1.8
Alcohol usually taken with meals	1.9	3.0	7.2	0.4	-1.3	-2.7
Time employed in main current job	1.9	2.2	6.3	0.5	-2.5	0.1
Emphysema/chronic bronchitis	1.9	2.1	2.7	-1.6	1.2	1.6
Chest pain or discomfort	1.9	2.8	5.6	-0.8	-2.4	1.4
Supplements: Vitamin C	1.9	2.3	3.1	-1.7	-0.8	-1.8
Financial situation satisfaction	1.9	2.3	6.8	0.2	0.2	2.6
Exposure to tobacco smoke outside home	1.8	2.4	5.0	-0.8	1.2	2.2
Number of operations (self-reported)	1.8	2.7	5.0	-1.6	0.9	-2.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	5.6	0.1	1.1	2.4
Depressed Affect (Nagel 2018)	1.7	3.6	4.9	-1.5	2.2	1.9
Pack years adult smoking proportion	1.7	2.5	4.3	-1.8	2.1	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	4.0	-2.0	1.7	-0.2
Pack years of smoking	1.7	2.5	4.4	-2.1	1.8	-0.2
Qualifications: CSEs or equivalent	1.6	2.1	4.2	-0.7	-1.3	2.0
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	4.4	-2.1	1.4	1.0
Medication: Ramipril	1.6	2.1	5.2	0.6	0.7	2.3
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.7	7.9	-0.2	-0.0	2.8
Number of live births	1.6	2.3	3.3	-0.6	-1.8	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	2.9	0.8	1.4	-1.7
Pulse wave reflection index	1.6	1.9	3.8	1.3	0.6	-1.9
Blood clot in the leg (DVT)	1.6	2.1	4.7	0.2	1.3	2.2
Back pain experienced in last month	1.6	2.4	5.7	-2.4	-0.1	1.2
Fasting Glucose	1.5	1.8	3.9	1.1	-0.5	2.0
Frequency of depressed mood in last 2 weeks	1.5	2.1	2.9	-1.4	1.7	1.2
Had other major operations	1.5	1.8	3.2	-1.8	0.7	-1.3
Prospective memory result	1.5	1.8	2.9	-1.2	1.0	1.7
Medication for pain relief, constipation, heartburn	1.5	2.6	6.0	1.3	-2.5	0.3
Alcohol intake frequency.	1.5	3.4	9.7	-0.7	0.2	3.1
Alzheimer’s Disease (in mother)	1.4	1.6	4.5	0.1	0.5	2.1
HDL Cholesterol	1.4	2.3	6.5	2.6	-0.5	0.2
Qualifications: A levels/AS levels or equivalent	1.4	3.1	9.0	0.3	-0.4	-3.0
Lung cancer (father)	1.4	1.6	4.5	2.1	-0.1	0.5
Qualifications: College or University degree	1.4	4.4	12.7	-0.7	-0.2	-3.6
Qualifications: nursing, teaching	1.4	2.2	3.8	-0.5	-1.6	-1.9
Smoking status: Current	1.4	2.2	5.6	-0.9	0.3	2.4
Medication: Blood pressure	1.4	2.6	3.4	-1.8	-1.5	1.5
Vitamin and mineral supplements	1.3	1.8	3.4	1.4	-0.1	1.8
Severe depression (siblings)	1.3	1.5	2.4	1.1	1.5	1.0
Hearing difficulty/problems with background noise	1.3	2.1	3.2	-1.8	-0.1	-1.8
Had menopause	1.3	1.6	4.9	0.1	-0.0	-2.2
Mouth/teeth dental problems: Dentures	1.3	2.3	6.5	0.2	0.5	2.5
Health satisfaction	1.3	1.7	4.3	-2.1	0.4	-0.8
Suffer from ‘nerves’	1.3	2.0	5.2	-0.5	-0.8	2.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.3	-0.7	-1.3	-1.5
Illnesses of father: Heart disease	1.3	1.8	3.0	-0.8	-1.3	-1.7
Friendships satisfaction	1.3	1.6	3.4	-0.2	-1.1	1.8
Verbal and Numeric Reasoning (VNR)	1.2	2.8	4.9	0.8	-1.6	-2.2
Neuroticism	1.2	2.9	7.3	-1.1	0.6	2.7
Current tobacco smoking	1.2	2.0	4.6	-1.2	0.2	2.1
Maternal smoking around birth	1.2	1.8	2.6	0.4	1.6	1.6
Noisy workplace	1.2	1.5	3.0	1.0	0.8	-1.7
Loud music exposure frequency	1.2	1.3	3.1	-1.8	0.8	0.0
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.9	-0.6	1.7	1.1
Number of full sisters	1.2	1.5	3.5	-1.9	-0.7	0.7
Mood swings	1.2	2.1	4.0	-0.5	1.5	2.0
Long-standing illness, disability or infirmity	1.2	1.8	5.0	-0.7	-0.2	2.2
Osteoporosis (self-reported)	1.2	1.5	3.8	-0.2	0.7	-2.0
Hearing aid user	1.2	1.3	1.7	-1.2	1.3	-0.9
Mother’s age at death	1.2	1.5	3.6	0.2	-1.9	-1.0
Medication: Bendroflumethiazide	1.2	1.8	4.1	-1.0	-0.5	2.0
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.2	-1.8	-0.8	-0.5
Worry (Nagel 2018)	1.1	2.3	6.0	-0.9	-0.4	2.4
Blood Eosinophil Count	1.1	8.4	18.3	-4.3	2.5	0.5
Hearing difficulty/problems: Yes	1.1	1.6	3.3	-1.1	-0.7	-1.8
Supplements: Glucosamine	1.1	1.5	3.3	-1.8	0.9	-0.6
Medication: Aspirin	1.1	1.5	2.9	-1.7	1.2	0.4
Mineral and other dietary supplements	1.1	1.5	2.1	1.4	-1.5	0.6
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.6	-1.6	0.4	-1.2
Heart attack/myocardial infarction (self-reported)	1.1	1.5	4.1	0.5	-0.3	2.0
Alcohol intake versus 10 years previously	1.0	1.5	3.6	0.4	1.9	0.9
Tense / ‘highly strung’	1.0	1.6	4.3	-0.8	0.1	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.5	-1.6	-0.6	-1.0
Wheeze or whistling in the chest in last year	1.0	1.8	3.7	1.2	-0.6	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.0	-0.4	1.4	1.2
Family relationship satisfaction	1.0	1.3	2.7	0.4	1.0	1.6
Average weekly champagne plus white wine intake	1.0	1.4	3.6	-0.8	-0.1	-1.9
Alcohol drinker status: Never	1.0	1.2	2.2	-1.1	0.1	1.5
Respiratory disease	0.9	1.9	3.4	-1.3	-1.8	-0.8
Sensitivity / hurt feelings	0.9	1.5	2.4	-1.6	1.4	-0.1
Fed-up feelings	0.9	1.6	1.8	-1.1	1.4	1.3
Stomach or abdominal pain in last month	0.9	1.1	1.9	-1.4	0.7	1.0
Hair/balding pattern: Pattern 2	0.9	1.2	2.2	1.5	1.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.7	-1.3	-0.8	-1.1
Fluid intelligence score	0.9	1.8	4.2	0.3	-2.1	-1.0
Glaucoma (self-reported)	0.9	1.0	2.5	-0.6	1.6	0.4
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.8	1.3	-1.1	-0.6
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.3	-1.1	1.5	0.0
Alcohol drinker status: Previous	0.9	1.0	3.0	-0.1	0.3	1.7
Bipolar Disorder or Schizophrenia	0.8	2.0	3.2	0.0	1.8	1.7
Schizophrenia vs Biploar Disorder	0.8	1.1	3.2	-0.2	0.1	1.8
Triglycerides	0.8	1.3	2.2	-0.1	1.5	1.3
Smoking Status	0.8	2.0	4.7	-1.1	0.1	2.2
Age when periods started (menarche)	0.8	2.0	5.9	-0.1	-2.4	0.3
High blood pressure (mother)	0.8	1.1	3.0	-0.1	-1.7	0.7
Neuroticism score	0.8	1.6	2.2	-1.5	0.7	1.5
Hair/balding pattern: Pattern 4	0.8	2.0	3.6	1.5	-1.9	-0.5
Birth weight of first child	0.8	1.5	2.2	1.5	-0.6	1.3
Medication: Blood pressure	0.8	1.5	3.9	0.1	0.7	2.0
Medication: Ibuprofen	0.8	0.9	2.4	0.1	1.5	-0.6
Unable to work because of sickness or disability	0.8	1.1	1.6	-0.6	1.1	1.3
Pain experienced in last month	0.8	1.4	1.7	1.1	-1.1	-1.3
Supplements: Calcium	0.8	0.9	1.5	-0.5	1.2	-1.0
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.4	0.7	-1.3	-2.1
Schizophrenia (2018)	0.7	1.5	2.9	0.2	1.3	1.7
HbA1C	0.7	0.8	1.1	0.9	0.6	1.0
Chronotype (morning person)	0.7	1.7	4.7	-0.4	2.2	-0.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.0	-1.4	-0.4	-0.3
Heart attack	0.7	0.9	2.8	0.2	-0.0	1.7
Allergy	0.7	1.5	2.1	1.4	1.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.3	-0.1	1.5	-0.4
Medication: Paracetamol	0.7	1.2	3.2	-0.2	1.8	0.6
Gout (self-reported)	0.7	1.0	2.6	-0.6	-1.6	0.1
High blood pressure (siblings)	0.7	1.1	3.0	-1.7	0.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.1	-0.8	-0.7	-1.1
Had major operations	0.7	0.8	1.1	-0.6	1.0	-1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.5	-1.2	-0.1	0.9
Eye problems/disorders: Cataract	0.7	0.8	2.1	0.4	-0.2	1.5
Medication: Aspirin	0.7	1.0	1.9	-1.4	0.9	0.4
Medication: Paracetamol	0.7	1.1	2.5	0.7	1.6	-0.5
Diastolic blood pressure, automated reading	0.7	2.0	5.8	-0.5	-0.2	2.4
Neuroticism (Nagel 2018)	0.6	1.4	2.4	-1.5	0.2	1.4
Alzheimer’s Disease (including proxy)	0.6	0.8	2.4	0.2	0.0	1.5
Primary Biliary Cirrhosis	0.6	0.8	1.3	1.0	1.1	-0.1
Rheumatoid Arthritis	0.6	0.8	2.3	0.2	0.3	1.5
Waist Hip Ratio (WHR)	0.6	2.7	6.6	-1.1	2.6	0.6
Medication: Metformin	0.6	0.9	1.6	0.1	1.1	1.3
Serious illness, injury or assault to yourself	0.6	0.7	1.8	1.3	-0.3	0.5
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.2	-1.2	-1.5	0.4
Multivitamins +/- minerals	0.6	0.7	1.7	-1.3	0.6	-0.5
Medication: Atenolol	0.6	0.8	1.0	-1.0	-0.8	0.9
Illnesses of siblings	0.6	0.8	1.3	1.1	-0.3	-1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	1.6	0.9	-0.9	-1.2
Medication: Amlodipine	0.6	0.9	1.7	-0.5	-0.8	1.3
Neck or shoulder pain in last month	0.6	0.8	1.9	-0.5	0.6	1.4
Age at last live birth	0.6	0.9	2.5	0.5	0.1	-1.6
Knee pain experienced in last month	0.6	0.9	1.9	-0.9	1.4	-0.3
Ever had bowel cancer screening	0.6	0.8	1.6	-0.6	1.2	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.9	-1.4	-0.0	-0.2
Miserableness	0.6	1.0	1.5	-0.6	1.2	1.0
Medication: Lisinopril	0.6	0.8	2.0	-1.4	-0.5	0.5
Ever smoked	0.6	1.0	2.7	-1.6	0.3	0.5
Irritability	0.6	1.0	3.0	-1.7	-0.1	-0.3
Fractured/broken bones in last 5 years	0.6	0.8	1.1	-0.8	-0.7	1.1
Reaction Time	0.5	1.0	2.9	-1.7	0.2	-0.1
Coronary Artery Disease (CAD)	0.5	0.5	1.0	0.4	-0.7	-1.0
Lupus	0.5	0.7	1.6	1.3	-0.7	-0.1
Schizophrenia (2014)	0.5	1.2	2.1	0.4	1.1	1.4
Ever had hysterectomy (womb removed)	0.5	0.5	0.9	0.8	1.0	0.3
Systolic blood pressure, automated reading	0.5	1.3	2.0	1.4	-1.4	-0.1
Trunk fat percentage	0.5	1.9	2.4	1.3	1.6	1.3
Pain all over the body in last month	0.5	0.6	0.7	-0.7	-0.9	0.6
Arm fat percentage (right)	0.5	1.8	2.3	1.5	1.5	0.9
Medication: Cholesterol lowering	0.5	0.8	1.2	-1.1	1.1	0.3
Illnesses of mother	0.5	0.6	1.6	-0.5	0.2	-1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.7	0.2	-0.1	1.3
Birth weight	0.5	1.1	2.6	-1.6	0.1	0.8
Overall health rating	0.5	1.0	2.4	-0.6	0.4	1.5
Arm fat percentage (left)	0.5	2.1	2.2	1.5	1.5	1.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.3	1.0	1.1	0.3
Medication for cholesterol	0.5	0.8	1.2	1.1	0.7	-0.9
Wears glasses or contact lenses	0.5	0.5	1.3	-0.2	1.1	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.5	-1.2	-0.5	0.1
Medication: Atorvastatin	0.5	0.6	1.0	-0.9	1.0	0.4
Commuting to job workplace: Cycle	0.5	0.6	1.0	-0.1	-1.0	1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-0.7	-0.1	-1.1
Bipolar Disorder (2018)	0.4	0.6	1.6	-0.4	1.3	0.2
Alzheimer’s Disease (in father)	0.4	0.4	1.0	1.0	-0.5	-0.2
Ovarian Cancer	0.4	0.6	1.0	-0.8	-0.4	-1.0
Crohns Disease (2012)	0.4	0.6	1.1	0.5	0.6	-1.1
Systolic Blood Pressure	0.4	1.8	4.4	1.0	-2.1	0.2
Allergy or Eczema	0.4	0.9	2.2	-1.5	-0.7	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.0	-1.0	0.9	0.8
Lung FEV1/FVC ratio	0.4	2.2	5.4	1.1	-0.0	-2.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.4	1.0	-0.2
Medication for hormone replacement therapy	0.4	0.5	0.8	-0.4	-0.7	-0.9
Hand grip strength (right)	0.4	1.2	1.8	0.2	-1.3	1.3
High blood pressure	0.4	1.0	2.8	-1.7	-0.5	0.3
Body mass index (BMI)	0.4	1.6	2.5	1.6	1.0	1.1
Number of incorrect matches in round	0.4	0.6	1.2	0.1	0.8	-1.1
Past tobacco smoking	0.4	0.7	1.5	1.2	0.5	-0.7
Forced vital capacity (FVC)	0.4	1.6	3.0	-1.7	0.9	0.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-0.2	1.1	-0.5
Depression (self-reported)	0.4	0.5	1.5	-0.2	0.1	1.2
Body fat percentage	0.4	1.6	2.2	1.3	1.5	1.0
Comparative body size at age 10	0.4	1.1	2.2	1.5	-1.0	-0.3
Eye problems/disorders: None of the above	0.4	0.4	1.3	0.1	0.1	-1.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	-0.5	0.9	0.7
Medication: Allopurinol	0.4	0.5	1.0	-1.0	-0.7	-0.1
Hypertension (Self-reported)	0.4	1.1	2.8	-1.7	-0.3	0.6
Commuting to job workplace: Walk	0.4	0.5	1.0	0.3	1.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.4	0.1	1.5	-0.4
Illnesses of father: High blood pressure	0.4	0.5	0.7	-0.3	-0.8	0.8
Average weekly beer plus cider intake	0.4	0.6	1.5	-0.6	-0.2	1.2
Risk taking	0.4	0.6	1.1	0.8	1.1	-0.3
Crohns Disease (2017)	0.3	0.7	1.6	0.8	0.2	-1.3
Irritable Bowel Disease (IBD)	0.3	0.8	1.7	1.3	0.0	-0.9
Cardiovascular Disease	0.3	1.1	2.3	-1.5	-0.4	-1.0
Hypothyroidism (self reported)	0.3	0.8	2.2	-1.5	0.1	-0.4
Lung FVC	0.3	1.7	2.1	-1.4	1.5	1.0
Number of treatments/medications taken	0.3	0.6	1.7	-1.3	0.2	-0.4
Medication: Co-codamol	0.3	0.3	0.6	-0.7	0.0	-0.7
Average weekly fortified wine intake	0.3	0.3	0.7	-0.8	-0.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.5	1.2	-0.5	0.7
Trunk fat mass	0.3	1.1	1.3	1.0	1.0	1.1
Waist circumference	0.3	1.1	1.8	0.2	1.3	1.1
Nervous feelings	0.3	0.6	1.1	0.0	-0.9	1.1
Financial difficulties in last 2 years	0.3	0.4	0.6	0.8	-0.7	-0.2
Medication: Simvastatin	0.3	0.5	0.8	-0.7	0.3	0.9
Worrier / anxious feelings	0.3	0.7	1.4	-1.2	-0.5	0.5
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	-0.8	-0.6	-0.5
Asthma	0.3	0.7	1.3	-0.8	-1.1	-0.1
Medication: Lansoprazole	0.3	0.3	0.5	-0.7	-0.5	-0.5
Arm fat mass (right)	0.3	1.3	2.6	1.6	0.7	0.9
Length of working week for main job	0.3	0.4	0.9	-1.0	-0.3	0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	1.9	-1.4	1.0	0.6
Number of children fathered	0.3	0.3	0.6	0.5	-0.8	-0.2
Angina (self-reported)	0.3	0.3	0.7	-0.5	-0.3	0.8
Medication: Omeprazole	0.3	0.4	0.7	-0.8	0.5	-0.5
Whole body fat mass	0.3	1.2	1.5	1.2	0.8	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	1.0	-0.1	0.3
Asthma (self-reported)	0.3	0.5	1.0	-0.7	-1.0	-0.2
Osteoarthritis (self-reported)	0.3	0.4	0.9	1.0	-0.6	0.3
Arm fat mass (left)	0.3	1.4	2.2	1.5	0.6	1.3
Number of self-reported non-cancer illnesses	0.3	0.6	1.4	-1.2	-0.1	-0.6
Ever taken oral contraceptive pill	0.3	0.3	0.7	-0.8	0.4	0.1
Commuting to job workplace: Public transport	0.3	0.4	0.6	-0.3	0.8	-0.6
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	-0.4	0.9	0.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.0	1.4	0.2	-0.5
Cholesterol lowering medication	0.3	0.4	0.9	-0.5	0.1	1.0
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	-0.1	-1.0	-0.1
Age at First Birth	0.2	0.2	0.5	0.2	0.7	0.3
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.5	0.7	0.3
Mean Putamen Volume	0.2	0.3	0.3	-0.5	-0.5	-0.5
Neuroticism (2016)	0.2	0.2	0.5	-0.4	0.1	-0.7
Blood Red Count	0.2	1.7	4.0	-2.0	-0.2	-1.0
Hand grip strength (left)	0.2	0.7	1.9	0.2	-1.4	0.1
Angina	0.2	0.3	0.7	-0.4	-0.2	0.8
Diabetes (father)	0.2	0.2	0.4	0.1	0.6	-0.4
Diabetes (mother)	0.2	0.2	0.3	0.3	-0.5	0.5
Relative age voice broke	0.2	0.4	0.5	0.6	-0.5	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.3	0.3	-0.6
Medication: Levothyroxine sodium	0.2	0.3	0.8	-0.9	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.1	0.7	-0.2	1.1
Trunk fat-free mass	0.2	0.9	2.4	-0.6	-1.6	0.0
Father’s age at death	0.2	0.3	0.7	0.9	0.4	-0.1
Falls in the last year	0.2	0.3	0.9	-0.1	0.9	0.2
Happiness	0.2	0.2	0.5	-0.2	0.7	0.3
Trunk predicted mass	0.2	0.9	2.5	-0.6	-1.6	-0.0
Standing height	0.2	2.0	4.1	-1.3	-2.0	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.6	0.7	-0.8	0.0
Leg fat percentage (right)	0.2	0.9	1.8	1.4	0.8	0.5
Mean time to correctly identify matches	0.2	0.4	1.2	-1.1	-0.1	-0.3
Leg fat mass (right)	0.2	0.8	1.3	1.1	0.6	0.9
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.6	0.4	-0.1
Diabetes diagnosed by doctor	0.2	0.4	0.7	-0.7	-0.1	0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	-0.2	0.5	-0.7
Guilty feelings	0.2	0.3	0.5	-0.7	-0.7	-0.2
High cholesterol (Self-reported)	0.2	0.4	1.2	0.1	1.1	-0.0
Leg fat percentage (left)	0.2	0.9	1.4	1.2	0.9	0.6
Age started oral contraceptive pill	0.2	0.3	0.8	0.9	-0.3	-0.2
Ever depressed for a whole week	0.2	0.2	0.3	0.3	0.5	-0.4
Myopia	0.2	0.3	0.8	0.9	0.3	-0.3
Heart disease (siblings)	0.2	0.2	0.4	0.4	-0.7	0.0
Leg fat mass (left)	0.2	0.8	0.9	1.0	0.7	1.0
Ulcerative Colitis (UC)	0.1	0.3	0.4	0.7	-0.5	-0.3
Major Depression (MDD)	0.1	0.1	0.3	-0.2	0.1	-0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	-0.4	-0.2
Ulcerative Colitis	0.1	0.2	0.4	-0.2	0.0	-0.7
Blood Platelet Count	0.1	1.2	1.9	1.4	1.3	-0.1
Blood White Count	0.1	0.9	1.7	1.3	0.1	-1.0
BMI	0.1	0.5	1.2	0.4	0.4	1.1
Height	0.1	1.2	1.7	-1.3	-1.3	0.4
Relative age of first facial hair	0.1	0.3	0.8	0.9	-0.2	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	-0.6	-0.1	-0.1
Taking other prescription medications	0.1	0.2	0.3	-0.4	-0.4	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.5	-0.0	-0.3
Sitting height	0.1	1.1	2.0	0.1	-1.4	-1.1
Impedance of leg (left)	0.1	0.3	0.5	-0.7	-0.2	-0.7
Leg predicted mass (left)	0.1	0.3	0.6	0.4	-0.2	0.8
Diabetes (self-reported)	0.1	0.2	0.4	-0.6	-0.3	0.3
Weight	0.1	0.5	0.9	0.8	-0.0	0.9
Hip circumference	0.1	0.5	0.9	1.0	-0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.4	-0.7	0.7	0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.4	0.2	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	0.5	-0.3
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.3	0.5	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.1	-0.3	0.2	0.4
Age at first live birth	0.1	0.1	0.4	0.2	-0.1	-0.6
Pulse wave peak to peak time	0.1	0.1	0.2	-0.4	-0.5	0.1
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.4	-0.0	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.1	-0.1	0.6
Heart disease (mother)	0.1	0.2	0.5	0.1	-0.7	-0.0
Comparative height size at age 10	0.1	0.4	1.0	0.0	0.3	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.2	0.4	-0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.1	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.2	0.5	0.6
Whole body fat-free mass	0.1	0.4	1.0	-0.2	-1.0	0.3
Breast cancer (self-reported)	0.1	0.2	0.3	-0.1	0.6	0.4
Whole body water mass	0.1	0.4	1.0	-0.2	-1.0	0.3
Arm fat-free mass (left)	0.1	0.5	1.6	0.1	-1.3	0.1
Arm predicted mass (left)	0.1	0.4	1.1	0.0	-1.1	0.1
Breast Cancer	0.0	0.0	0.0	0.1	0.2	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.4	0.6	0.6	0.4	0.8
Hair Pigment	0.0	0.9	1.3	-1.0	1.1	-0.7
Tanning	0.0	0.6	1.4	-0.5	-1.2	-0.2
Impedance of leg (right)	0.0	0.2	0.5	-0.3	-0.1	-0.7
Leg fat-free mass (left)	0.0	0.2	0.6	0.4	0.0	0.8
Impedance of arm (right)	0.0	0.1	0.1	0.1	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.2	0.4	-0.2	0.6	-0.1
Impedance of arm (left)	0.0	0.1	0.1	-0.3	0.2	0.3
Arm fat-free mass (right)	0.0	0.2	0.6	-0.3	-0.8	0.2
Number of full brothers	0.0	0.0	0.0	-0.1	0.2	0.1
Migraine (self-reported)	0.0	0.0	0.0	0.1	-0.1	0.0
Arm predicted mass (right)	0.0	0.2	0.5	-0.2	-0.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	-0.0	-0.3	0.1
Smoking status: Previous	0.0	0.1	0.2	-0.4	-0.1	0.2
Leg fat-free mass (right)	0.0	0.2	0.6	0.1	-0.2	0.8
Leg predicted mass (right)	0.0	0.2	0.6	0.1	-0.2	0.8
Basal metabolic rate	0.0	0.2	0.4	0.1	-0.6	0.6
Impedance of whole body	0.0	0.1	0.2	-0.2	0.4	-0.1

Hub : Genes

CDH24

Models

Trait associations