TWAS hub - PSMB5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1290	0.0640	4.4e-02	0.144	0.000	0.189	0.228	0.196	3.3e-17	3.7e-01	1.9e-22	2.3e-27	2.5e-23
2	GTEx	Testis	0.2980	0.1010	4.3e-03	0.007	NA	0.085	NA	0.055	1.5e-01	NA	1.3e-04	NA	1.8e-03
3	YFS	Blood	0.0535	0.0142	2.0e-07	0.027	0.014	0.037	0.052	0.040	2.5e-09	1.5e-05	2.4e-12	1.5e-16	3.9e-13
4	TCGA	Breast Invasive Carcinoma	0.0684	0.0281	2.7e-04	0.027	0.022	0.027	NA	0.028	2.7e-06	2.3e-05	2.7e-06	NA	1.7e-06
5	TCGA	Brain Lower Grade Glioma	0.0810	0.0373	1.2e-04	0.036	0.024	0.038	NA	0.043	5.5e-05	7.6e-04	3.1e-05	NA	1.0e-05
6	TCGA	Skin Cutaneous Melanoma	0.2830	0.1180	7.4e-03	0.077	0.043	0.047	NA	0.100	4.4e-03	2.6e-02	2.2e-02	NA	1.3e-03
7	TCGA	Thyroid Carcinoma	0.1990	0.0610	9.4e-06	0.071	0.044	0.075	NA	0.074	2.0e-07	3.7e-05	8.1e-08	NA	1.1e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Diabetes diagnosed by doctor	5.4	8.8	13.9	3.6	3.6	3.7	2.4	1.3	1.8	3.4
Maternal smoking around birth	4.3	6.2	12.6	0.7	3.6	1.1	3.4	3.4	2.2	1.1
Prostate Cancer	3.9	5.4	14.6	0.6	3.8	1.1	2.7	3.3	1.8	0.6
Ulcerative Colitis	3.9	5.7	10.5	-2.5	-2.2	-2.6	-2.3	-1.6	-1.9	-3.2
Diabetes (self-reported)	3.8	5.9	10.8	2.6	3.3	2.8	2.3	1.5	1.2	2.6
Medication: Metformin	3.6	5.1	9.5	2.1	3.1	2.4	2.5	2.4	1.2	1.8
Taking other prescription medications	3.4	5.2	9.9	3.0	2.6	3.1	1.7	0.9	1.2	2.3
Ever had hysterectomy (womb removed)	3.3	3.7	9.0	3.0	1.7	3.0	0.5	0.1	0.8	2.1
Number of self-reported non-cancer illnesses	3.3	5.7	11.8	3.3	2.3	3.4	2.0	1.4	-0.5	2.4
Type 2 Diabetes (T2D) (2018)	3.1	5.9	10.8	3.2	3.0	3.3	1.6	0.9	1.0	2.5
Townsend deprivation index at recruitment	3.1	4.3	7.6	1.8	2.8	2.2	2.4	2.6	0.4	1.4
Number of treatments/medications taken	2.9	5.3	7.6	2.3	2.4	2.4	2.8	2.4	1.9	1.9
Chest pain or discomfort	2.9	4.2	11.2	2.9	1.3	2.7	1.0	-0.3	0.4	3.4
Ever had prostate specific antigen (PSA) test	2.9	3.4	5.8	2.2	1.3	2.3	1.4	0.9	1.9	2.4
Myopia	2.8	4.1	6.0	2.4	2.4	2.5	2.1	1.5	0.2	2.2
Pulse rate	2.5	4.1	14.2	0.7	3.8	0.9	2.4	2.0	1.5	1.2
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	6.9	-1.6	-2.6	-1.9	-2.4	-2.4	-0.4	-1.7
Osteoarthritis (self-reported)	2.5	3.2	5.6	1.7	2.4	1.9	1.5	0.9	1.7	2.1
Hearing aid user	2.5	2.8	6.5	2.5	1.1	2.5	0.1	-0.1	1.0	2.1
Ulcerative Colitis (UC)	2.4	4.5	8.5	-1.7	-2.4	-1.7	-2.9	-2.4	-0.5	-2.4
Medication: Ramipril	2.4	3.0	8.3	0.9	0.8	1.1	2.9	2.8	1.5	0.6
Commuting to job workplace: Cycle	2.4	2.9	9.0	-1.3	-1.7	-1.4	-1.2	-0.6	-3.0	-1.8
Pulse wave peak to peak time	2.0	2.4	4.4	-2.1	-1.3	-2.1	-1.4	-0.2	-0.6	-2.0
Diabetes (father)	1.9	2.4	4.4	2.1	1.3	1.9	1.3	0.4	1.2	1.9
Pulse wave reflection index	1.9	2.4	3.8	1.5	-1.8	1.3	-1.6	-2.0	-1.6	0.9
Migraine (self-reported)	1.9	2.4	5.2	-1.5	-1.1	-1.6	-1.4	-1.3	-2.3	-1.3
Alzheimer’s Disease (in mother)	1.8	2.1	4.8	-2.2	-0.3	-2.0	-0.5	0.1	-1.6	-1.7
Irritable Bowel Disease (IBD)	1.8	4.3	8.1	-1.4	-2.1	-1.6	-2.9	-2.8	-0.2	-2.2
Fasting Glucose	1.8	2.1	4.1	1.8	2.0	1.9	0.3	0.0	-1.2	1.6
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	3.9	1.7	1.7	2.0	1.6	1.6	0.7	1.2
Pulse wave Arterial Stiffness index	1.8	2.1	3.9	2.0	1.0	2.0	1.4	0.1	0.4	1.9
Type 2 Diabetes (T2D) (2012)	1.7	2.0	5.7	2.0	2.4	2.1	0.0	0.0	0.0	0.0
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	5.3	-2.1	-0.1	-1.8	-0.5	0.2	-1.5	-2.3
Pulse rate, automated reading	1.7	5.5	30.1	1.6	5.5	1.7	-0.3	-0.0	0.7	1.6
Leg pain on walking	1.7	2.2	4.4	1.3	1.1	1.3	1.4	1.2	2.1	1.6
Age started oral contraceptive pill	1.7	2.1	4.1	-0.7	-2.0	-0.9	-2.0	-1.8	-0.7	-1.1
Average weekly spirits intake	1.6	2.0	4.2	-1.5	-1.8	-1.6	-1.4	-0.0	-0.2	-2.1
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	6.4	-1.2	-2.0	-1.2	-2.5	-1.8	-1.2	-1.0
Breast cancer (self-reported)	1.6	1.9	4.6	-0.3	-1.3	-0.6	-1.5	-2.0	-2.1	-0.4
Medication: Bendroflumethiazide	1.6	2.4	4.7	2.1	1.2	2.0	1.3	0.6	0.5	2.2
Body Mass Index (BMI) (2010)	1.5	2.0	5.2	1.1	2.0	1.1	0.9	0.1	1.3	2.3
Hair/balding pattern: Pattern 2	1.5	1.9	3.9	-1.8	-1.2	-2.0	-0.8	-0.6	0.5	-1.8
Mood swings	1.5	2.8	7.4	-0.0	2.6	0.4	2.1	2.7	0.5	0.6
Basal cell carcinoma (self-reported)	1.5	1.8	5.3	0.2	-2.1	-0.2	-1.6	-2.3	-0.6	0.0
Past tobacco smoking	1.4	2.5	5.6	-1.1	-0.9	-1.3	-2.4	-1.9	-1.7	-1.3
Worry too long after embarrassment	1.4	2.4	4.5	-2.1	0.1	-1.9	1.8	1.6	1.3	-1.0
Emphysema/chronic bronchitis	1.4	1.5	2.8	0.8	1.7	0.8	1.4	1.5	1.2	1.0
Long-standing illness, disability or infirmity	1.4	2.1	5.8	1.9	2.4	2.0	-0.2	-0.2	0.0	1.0
Medication: Gliclazide	1.4	1.6	5.8	1.0	1.2	1.0	0.8	0.7	2.4	0.8
Alcohol drinker status: Never	1.4	1.7	4.2	-1.6	-1.1	-1.6	-1.1	-0.5	0.1	-2.0
Schizophrenia (2014)	1.3	3.0	6.5	-2.3	-0.0	-2.3	-0.5	0.4	2.6	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	8.1	0.1	0.5	0.6	1.7	2.8	-0.1	-0.3
Wheeze or whistling in the chest in last year	1.3	2.4	4.6	2.1	1.6	2.1	0.9	0.7	0.3	1.9
Number of full sisters	1.3	1.6	4.0	-1.9	0.7	-1.6	-0.3	0.6	0.2	-2.0
Commuting to job workplace: Walk	1.3	1.4	3.2	1.8	0.2	1.7	-0.4	-1.1	-0.0	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	6.4	-2.5	-1.6	-2.3	-0.3	-0.3	1.0	-1.9
Irritability	1.3	2.3	4.1	1.3	2.0	1.6	1.6	1.6	0.0	1.6
Heart disease (siblings)	1.3	1.5	2.8	1.6	1.0	1.5	-0.6	-1.3	-0.3	1.7
Smoking Status	1.2	3.0	4.6	2.1	1.7	2.1	1.7	1.1	0.7	2.0
Hearing difficulty/problems: Yes	1.2	1.8	3.3	1.6	1.0	1.7	0.9	0.6	1.3	1.8
Severe depression (siblings)	1.2	1.4	3.3	-0.1	-0.6	-0.2	-1.8	-1.8	-1.7	-0.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	2.9	-1.0	-0.9	-1.0	-1.7	-0.6	0.0	-1.6
Qualifications: None of the above	1.2	2.5	6.0	1.2	2.4	1.5	1.2	1.8	1.5	1.0
Noisy workplace	1.2	1.5	3.7	-1.3	-0.4	-1.3	-1.9	-1.6	-0.1	-0.9
Qualifications: A levels/AS levels or equivalent	1.2	2.8	7.2	-1.8	-2.7	-2.0	-1.1	-1.0	-0.4	-1.7
Length of working week for main job	1.2	1.3	2.5	0.7	1.0	0.7	1.6	0.8	1.4	1.3
Suffer from ‘nerves’	1.2	1.8	3.9	-2.0	-1.1	-2.0	0.4	0.9	1.0	-1.3
Smoking status: Previous	1.2	1.8	3.6	1.0	0.5	1.2	1.9	1.4	1.8	1.1
Medication for cholesterol	1.2	1.8	3.0	-1.7	-1.1	-1.7	-1.3	-1.5	0.3	-1.1
Ever smoked	1.2	2.1	4.2	1.0	0.3	1.1	2.1	1.8	2.0	1.0
Major Depression (MDD)	1.1	1.3	2.9	-1.7	-0.8	-1.5	0.1	0.0	0.9	-1.7
Breast Cancer	1.1	2.7	4.3	2.0	1.2	2.1	0.1	-0.8	-2.0	2.1
Rheumatoid Arthritis	1.1	1.5	3.6	1.5	1.9	1.3	0.6	0.0	-0.1	1.7
Frequency of depressed mood in last 2 weeks	1.1	1.6	4.1	-1.5	-0.1	-1.2	1.4	2.0	0.4	-1.2
Time employed in main current job	1.1	1.2	2.6	-1.4	-0.6	-1.4	0.5	1.2	-0.4	-1.6
Medication: Cholesterol lowering	1.1	1.6	4.1	0.4	1.7	0.6	2.0	1.7	0.8	0.4
Tense / ‘highly strung’	1.1	1.9	3.8	1.2	2.0	1.3	1.7	1.0	0.9	1.3
Medication: Amlodipine	1.1	1.6	3.5	1.9	0.5	1.7	1.2	-0.0	0.6	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	4.6	0.7	2.2	0.9	1.4	1.3	0.2	0.6
Qualifications: College or University degree	1.1	3.5	7.6	-1.4	-2.5	-1.7	-1.1	-1.8	-2.8	-1.4
Medication: Blood pressure	1.1	1.9	3.8	1.6	1.5	1.5	1.9	1.1	0.2	1.1
Medication: Ibuprofen	1.1	1.4	2.8	0.5	0.9	0.6	1.7	1.1	1.4	1.5
Ever depressed for a whole week	1.1	1.4	3.0	-1.7	-1.1	-1.7	-0.1	0.4	-0.4	-1.6
Pack years adult smoking proportion	1.0	1.5	5.2	0.9	2.3	1.3	0.8	1.3	-0.2	0.8
Loud music exposure frequency	1.0	1.1	2.0	-1.4	-0.6	-1.3	-0.1	1.2	0.4	-1.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.0	-1.7	0.1	-1.6	0.5	0.6	0.8	-1.0
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	3.1	1.8	0.1	1.6	0.9	0.3	0.5	1.4
Pack years of smoking	1.0	1.5	5.0	0.9	2.2	1.2	0.9	1.3	-0.3	0.9
Medication for hormone replacement therapy	0.9	1.0	3.2	0.6	0.7	0.9	1.2	1.8	-0.4	0.5
Serious illness, injury or assault to yourself	0.9	1.1	3.6	0.2	1.4	0.5	0.7	0.8	1.9	0.8
Medication: Levothyroxine sodium	0.9	1.5	3.3	1.4	1.8	1.4	0.4	1.1	0.7	1.0
Medication: Simvastatin	0.9	1.3	3.0	1.0	1.7	1.2	1.1	1.2	-0.8	0.6
Peak expiratory flow (PEF)	0.9	2.0	4.0	-1.7	-1.8	-1.4	-1.0	-0.8	-0.5	-2.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.0	0.4	1.4	0.7	1.2	1.0	1.3	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.2	1.4	0.2	1.3	0.6	0.1	0.4	1.8
Knee pain experienced in last month	0.9	1.3	3.6	0.4	0.2	0.4	1.8	1.3	1.9	0.7
Illnesses of siblings: Diabetes	0.9	1.1	4.4	0.3	1.2	0.4	1.1	2.1	0.6	0.1
Qualifications: nursing, teaching	0.9	1.5	4.2	-1.0	-2.0	-1.1	-0.8	-1.2	0.1	-1.3
Eye problems/disorders: Cataract	0.9	1.1	2.0	1.3	1.4	1.3	0.3	0.1	0.9	1.1
Commuting to job workplace: Public transport	0.9	1.1	1.7	1.2	0.8	1.3	0.8	0.8	1.0	1.1
Illnesses of father: High blood pressure	0.9	1.1	2.6	-1.2	-0.7	-1.2	-1.0	-0.5	0.8	-1.6
Cholesterol lowering medication	0.9	1.4	3.3	1.1	1.8	1.3	0.9	1.4	-0.5	0.6
Neuroticism (2016)	0.8	1.1	2.3	-1.2	-0.2	-0.9	0.7	1.1	1.5	-1.2
Blood Red Count	0.8	7.8	25.2	1.1	3.0	1.8	3.5	5.0	1.5	1.1
Diabetes (mother)	0.8	1.0	3.1	0.8	1.8	0.9	0.6	1.0	0.1	0.8
Chronic bronchitis/emphysema (father)	0.8	0.9	1.9	0.2	0.9	0.2	-1.2	-1.4	-1.4	0.3
Waist circumference	0.8	2.9	4.5	1.8	2.1	2.0	1.9	1.3	0.5	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.9	0.4	1.3	0.7	1.6	2.0	0.5	0.4
Hip circumference	0.8	3.6	7.5	2.7	1.7	2.7	1.5	0.3	-0.5	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.3	0.7	0.9	0.8	1.4	0.9	0.6	1.5
Shortness of breath walking on level ground	0.8	0.9	4.8	0.5	2.2	0.6	0.1	0.0	0.9	0.3
Neck or shoulder pain in last month	0.8	1.1	3.4	-0.6	1.0	-0.4	0.9	1.8	1.5	-0.2
Family relationship satisfaction	0.8	0.9	1.8	1.2	0.9	1.4	0.8	-0.2	-0.4	1.3
Illnesses of father: Heart disease	0.8	1.1	2.4	0.0	-1.4	-0.2	-1.6	-1.5	-0.7	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.0	-0.6	-0.4	-0.7	-0.8	-1.2	-1.7	-0.6
Guilty feelings	0.8	1.1	2.7	-1.6	-1.1	-1.4	0.7	0.8	0.5	-0.8
Medication: Atorvastatin	0.8	1.0	1.7	0.9	1.0	0.9	1.0	0.7	1.3	1.0
Depression (Nagel 2018)	0.7	1.1	4.9	-0.5	0.0	-0.2	1.4	2.2	0.2	-0.8
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.5	-2.1	-1.8	-2.1	-0.0	-0.2	0.6	-1.6
Triglycerides	0.7	1.2	3.3	0.5	0.7	0.4	-1.0	-0.9	-1.5	-1.8
BMI	0.7	4.1	7.0	2.6	2.2	2.6	1.8	0.8	0.8	2.3
Lung FVC	0.7	3.6	5.9	-2.4	-2.1	-2.2	-1.7	-1.2	-0.4	-2.3
Systolic blood pressure, automated reading	0.7	2.1	3.8	-1.2	-1.4	-1.2	-1.7	-0.3	-1.7	-2.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.3	0.8	0.9	0.9	0.8	1.1	1.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	4.2	-1.4	0.8	-1.1	0.3	1.6	-0.3	-2.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.9	1.7	1.5	1.7	-0.2	0.2	-0.1	0.9
Number of full brothers	0.7	0.8	1.8	1.3	0.9	1.2	-0.2	-0.2	-0.0	1.3
Medication: Seretide 50 evohaler	0.7	0.8	2.3	-0.1	-0.5	-0.1	-1.5	-1.1	-1.2	-0.5
Average weekly champagne plus white wine intake	0.7	1.0	2.2	-1.2	-1.3	-1.3	-0.0	-0.0	1.5	-0.5
Supplements: Calcium	0.7	0.8	1.5	1.2	-0.6	1.2	-0.8	-0.9	-0.7	0.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	4.0	-0.7	0.6	-0.6	0.2	0.8	2.0	-0.3
Schizophrenia (2018)	0.6	1.1	4.7	-0.7	1.3	-0.8	-0.4	0.4	2.2	-0.3
Ovarian Cancer	0.6	0.7	1.5	1.2	-0.7	1.1	-0.4	-0.1	-0.6	1.2
Age at First Birth	0.6	0.9	2.3	0.0	-1.3	-0.2	-0.9	-1.5	0.7	0.9
Coronary Artery Disease (CAD)	0.6	0.8	5.1	0.3	2.3	0.3	0.0	0.0	0.0	0.0
Trunk fat percentage	0.6	2.2	3.6	1.6	1.3	1.9	1.7	1.5	0.5	1.4
Mouth/teeth dental problems	0.6	0.9	1.8	1.3	-1.1	1.0	0.5	-0.5	-0.1	1.3
Worrier / anxious feelings	0.6	1.1	2.8	-1.7	-0.3	-1.5	0.6	0.9	-0.2	-1.1
Glaucoma (self-reported)	0.6	0.7	1.5	0.4	0.9	0.5	-1.2	-0.9	0.9	0.4
Birth weight	0.6	1.2	3.1	-1.8	0.2	-1.4	-0.2	0.8	-0.8	-1.4
Health satisfaction	0.6	0.8	1.5	-1.1	0.2	-0.9	-1.1	-0.1	0.8	-1.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	3.0	0.3	1.7	0.4	0.9	0.7	0.5	0.3
Heart disease (mother)	0.6	0.7	2.5	-0.1	0.6	0.0	1.4	1.6	0.2	0.0
Average weekly red wine intake	0.6	0.8	3.0	-0.3	0.3	-0.3	1.7	1.5	0.5	0.2
Ever taken oral contraceptive pill	0.6	0.7	2.5	0.3	0.6	0.2	1.6	1.2	-0.6	0.4
Fractured/broken bones in last 5 years	0.6	0.8	2.8	0.2	-0.5	0.3	-1.2	-1.0	-1.7	0.1
Unable to work because of sickness or disability	0.6	0.8	2.5	0.7	1.0	0.9	-1.6	-0.8	-0.2	0.3
Mean Putamen Volume	0.5	0.6	1.2	0.9	0.8	1.1	0.5	0.4	0.1	1.0
HDL Cholesterol	0.5	0.8	3.4	0.9	0.1	0.6	-0.1	-0.6	1.0	1.9
Systolic Blood Pressure	0.5	2.6	7.0	-2.0	-1.2	-1.9	-0.4	1.3	-1.0	-2.7
Sensitivity / hurt feelings	0.5	0.8	2.2	-0.7	-0.6	-0.7	-1.5	-1.0	-1.0	-0.2
Angina	0.5	0.7	2.0	-0.1	0.0	-0.1	1.4	1.0	1.3	0.4
Hand grip strength (right)	0.5	1.4	3.1	-1.8	-1.0	-1.7	-0.4	-0.7	-0.1	-1.4
Current tobacco smoking	0.5	0.7	1.9	0.8	1.4	0.8	0.8	1.1	-0.1	0.5
Stomach or abdominal pain in last month	0.5	0.7	2.0	0.5	1.4	0.8	0.8	0.8	0.3	0.6
Medication: Atenolol	0.5	0.6	1.1	-0.7	-0.7	-0.9	-0.3	0.6	-1.0	-1.0
Body mass index (BMI)	0.5	2.0	4.2	1.7	2.1	1.8	1.2	0.6	0.1	1.4
Trunk fat mass	0.5	2.1	3.6	1.6	1.5	1.8	1.9	1.4	0.4	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.6	0.0	1.9	0.3	1.1	1.6	0.6	-0.5
Illnesses of siblings	0.5	0.7	1.6	-0.6	-0.9	-0.7	-1.0	-1.3	0.3	-0.7
Arm fat percentage (right)	0.5	1.9	2.8	1.7	1.1	1.7	1.7	1.0	0.8	1.5
Mouth/teeth dental problems: Dentures	0.5	0.9	2.7	0.0	1.6	0.2	1.2	1.4	0.3	0.0
Medication: Lansoprazole	0.5	0.6	1.3	0.4	1.0	0.3	1.1	1.0	0.5	0.6
Birth weight of first child	0.5	1.0	2.1	1.1	1.4	1.2	0.6	0.2	0.3	1.2
Forced vital capacity (FVC), Best measure	0.5	1.9	4.7	-1.9	-1.3	-1.6	-0.2	-0.2	0.1	-2.2
Body fat percentage	0.5	2.2	3.3	1.6	1.5	1.8	1.6	1.4	0.6	1.4
Comparative body size at age 10	0.5	1.3	4.9	-1.0	0.2	-1.1	-1.1	-2.2	0.4	-0.4
Whole body fat mass	0.5	2.2	3.5	1.7	1.6	1.9	1.8	1.3	0.6	1.3
Age at last live birth	0.5	0.8	3.7	-0.5	0.0	-0.4	1.0	0.5	1.9	0.4
Arm fat percentage (left)	0.5	1.8	2.8	1.6	1.3	1.7	1.5	1.1	0.6	1.4
Handedness (chirality/laterality): Left-handed	0.5	0.7	2.3	0.9	-0.3	0.7	-0.4	-0.6	1.5	0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	2.4	0.1	0.0	0.2	1.6	0.8	0.1	1.0
Arm fat mass (left)	0.5	1.9	3.2	1.7	1.6	1.8	1.5	0.9	0.4	1.3
Mother’s age at death	0.5	0.6	1.5	-0.4	-0.4	-0.5	-0.8	-1.2	-1.2	-0.4
High cholesterol (Self-reported)	0.5	0.9	1.4	0.9	1.1	1.0	0.8	0.9	-1.2	0.5
Number of operations (self-reported)	0.5	0.7	1.9	0.7	-0.9	0.6	-0.8	-1.4	0.6	0.2
Bipolar Disorder or Schizophrenia	0.4	0.9	2.5	-1.0	0.6	-1.0	-1.0	-0.3	1.6	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.6	2.9	0.7	1.7	0.7	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.4	0.9	2.2	-1.5	-0.2	-1.3	0.4	0.8	0.8	-1.0
Alzheimer’s Disease (in father)	0.4	0.4	0.9	0.8	0.2	0.8	-0.3	0.4	1.0	0.8
HbA1C	0.4	0.4	2.0	0.3	0.2	0.5	0.0	0.9	-1.4	-0.2
Primary Biliary Cirrhosis	0.4	0.6	1.1	-0.6	0.5	-1.0	-0.7	-0.6	-0.6	-1.0
Vitamin and mineral supplements	0.4	0.5	1.3	0.4	1.1	0.2	-0.5	-0.8	0.8	0.7
Multivitamins +/- minerals	0.4	0.6	2.2	-0.6	-1.5	-0.4	0.5	0.6	-0.7	-0.4
Forced vital capacity (FVC)	0.4	1.7	3.8	-1.8	-1.4	-1.6	-0.2	-0.3	0.2	-1.9
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-1.1	-0.3	-1.0	-0.1	0.6	0.5	-0.8
Heart attack	0.4	0.5	1.3	-0.0	0.8	-0.0	1.1	1.1	0.9	0.1
Alcohol intake versus 10 years previously	0.4	0.6	2.3	0.6	0.5	0.6	-0.3	0.0	1.5	0.8
Father’s age at death	0.4	0.5	1.1	-0.6	1.1	-0.5	0.2	0.8	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.2	-1.5	-1.5	-1.3	-0.3	-0.8	-0.3	-1.8
Prospective memory result	0.4	0.5	1.1	-0.6	0.6	-0.6	-0.0	0.5	0.8	-1.1
Arm fat mass (right)	0.4	1.8	2.9	1.6	1.4	1.7	1.5	0.7	0.5	1.3
Blood clot in the leg (DVT)	0.4	0.5	2.4	-0.6	0.5	-0.5	-0.2	0.3	1.6	-0.3
Leg fat percentage (right)	0.4	1.4	2.2	1.4	1.3	1.5	1.2	0.9	0.4	1.2
Number of children fathered	0.4	0.5	1.7	-0.0	-0.2	0.0	-0.8	-1.0	1.3	-0.1
Eye problems/disorders: None of the above	0.4	0.5	1.7	-0.3	-1.3	-0.3	0.3	-0.1	-1.1	-0.5
Angina (self-reported)	0.4	0.6	1.7	-0.3	-0.3	-0.4	1.1	0.8	1.3	0.2
Medication: Allopurinol	0.4	0.5	0.8	0.7	-0.1	0.6	0.9	0.9	0.5	0.8
Leg fat mass (right)	0.4	1.4	2.5	1.4	1.6	1.4	1.3	0.8	0.2	1.0
Alcohol intake frequency.	0.4	0.8	2.9	-0.1	-0.5	-0.2	-1.5	-1.7	0.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	0.6	0.2	0.7	0.8	0.6	-0.3	1.0
Mineral and other dietary supplements	0.4	0.6	3.1	0.3	0.6	0.2	0.1	0.1	1.8	0.5
Asthma (self-reported)	0.4	0.8	3.6	0.0	-0.4	-0.3	-1.1	-1.9	-0.5	0.2
Smoking status: Current	0.4	0.7	1.7	0.4	1.3	0.5	0.9	1.2	-0.2	0.5
Miserableness	0.4	0.7	3.0	-0.6	0.8	-0.1	-0.2	0.7	-1.7	-0.6
Medication: Paracetamol	0.4	0.6	1.1	0.9	-0.8	0.7	1.1	0.7	0.5	0.9
Leg fat percentage (left)	0.4	1.5	2.2	1.3	1.4	1.5	1.3	1.1	0.7	1.1
Average weekly beer plus cider intake	0.4	0.6	2.8	-0.4	0.7	-0.0	0.9	1.7	-0.1	0.2
Leg fat mass (left)	0.4	1.4	2.5	1.4	1.6	1.5	1.4	0.8	0.2	1.0
Bipolar Disorder (2018)	0.3	0.4	1.3	-0.6	-0.8	-0.7	0.0	-1.1	0.0	-0.6
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	0.5	1.3	0.9	0.4	1.1	0.1	0.5
Neuroticism (Nagel 2018)	0.3	0.6	2.1	-0.9	0.5	-0.4	0.9	1.5	0.5	-0.5
Crohns Disease (2017)	0.3	0.7	2.6	-0.0	-0.6	-0.4	-0.7	-1.6	0.9	-0.3
Blood Eosinophil Count	0.3	2.4	11.3	-0.6	-1.4	-1.1	0.5	-1.2	-3.4	-0.7
Blood White Count	0.3	2.5	9.0	-0.6	-1.2	-1.1	-2.4	-3.0	-0.3	-0.4
Heel T-Score	0.3	2.7	6.6	-1.8	1.2	-1.7	-1.4	-1.0	-1.4	-2.6
Allergy or Eczema	0.3	0.7	1.8	-0.2	-1.4	-0.4	-0.9	-0.9	0.8	-0.5
Hypothyroidism (self reported)	0.3	0.8	1.7	1.3	1.1	1.3	-0.1	0.4	-0.8	0.5
Respiratory disease	0.3	0.7	3.1	0.1	-0.8	-0.2	-1.1	-1.8	0.0	0.2
Lung FEV1/FVC ratio	0.3	1.7	3.6	1.7	0.9	1.5	1.4	-0.5	-0.5	1.9
Age when periods started (menarche)	0.3	0.7	2.4	-0.1	-0.5	0.1	1.2	1.5	0.6	-0.3
Supplements: Glucosamine	0.3	0.4	1.7	-0.3	-0.0	-0.2	1.3	1.0	0.2	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	-0.3	-0.4	-0.0	0.8	0.7	0.9	-0.4
Alcohol usually taken with meals	0.3	0.5	2.5	-0.3	-0.9	-0.3	-0.2	-0.1	1.6	0.0
Nervous feelings	0.3	0.6	1.4	-1.1	-0.0	-1.2	0.2	0.2	0.9	-0.6
Hearing difficulty/problems with background noise	0.3	0.4	1.0	1.0	0.0	0.9	0.3	0.1	0.0	1.0
Financial difficulties in last 2 years	0.3	0.5	1.6	-0.1	1.3	0.0	0.8	0.8	-0.2	0.6
Fluid intelligence score	0.3	0.6	1.2	-0.8	-1.0	-0.6	1.1	0.7	0.8	-0.4
Neuroticism score	0.3	0.6	1.1	-1.0	1.0	-0.8	0.4	0.9	-0.1	-0.4
Weight	0.3	1.5	3.0	1.6	1.4	1.7	1.4	0.5	-0.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.7	0.4	1.3	0.8	0.2	0.6	-0.5	-0.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	0.7	-0.1	0.7	-0.4	-0.6	-1.2	0.1
Happiness	0.3	0.4	0.7	-0.9	-0.7	-0.8	-0.6	-0.3	0.1	-0.5
Asthma	0.3	0.6	2.8	0.0	-0.5	-0.3	-0.9	-1.7	-0.5	0.1
Lung cancer (father)	0.3	0.4	0.8	-0.7	0.7	-0.6	-0.5	-0.4	-0.9	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.0	-1.2	-1.0	-1.0	0.1	-0.4	-0.3	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.1	0.9	0.2	0.6	0.8	1.1	-0.2
Medication: Paracetamol	0.3	0.4	0.6	0.8	-0.7	0.7	0.5	0.4	-0.6	0.7
Headache pain in last month	0.3	0.5	1.3	-0.3	-0.8	-0.3	-1.1	-0.9	-0.3	-0.6
Gout (self-reported)	0.3	0.4	0.5	-0.5	-0.7	-0.7	0.5	0.6	-0.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	0.3	-0.3	-0.1	-0.6	-1.1	0.8	0.7
High blood pressure (siblings)	0.3	0.4	0.9	0.6	0.3	0.6	0.9	0.9	-0.1	0.5
Age at first live birth	0.3	0.5	1.1	-0.8	-0.9	-0.7	-0.4	-0.6	1.1	-0.4
Mean time to correctly identify matches	0.3	0.6	1.1	1.0	0.6	1.0	0.2	-0.3	-0.9	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.7	-0.2	0.9	-0.1	0.0	-0.1	1.3	0.4
Had major operations	0.3	0.4	0.6	0.7	0.0	0.7	-0.8	-0.8	-0.7	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.1	0.5	-0.2	-1.1	-0.8	0.5	0.1
Hypertension (Self-reported)	0.3	0.9	2.4	1.6	-0.3	1.4	0.6	0.3	-0.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.7	-0.1	0.4	-0.1	1.6	1.0	0.7	-0.3
Friendships satisfaction	0.3	0.3	0.9	0.6	0.5	0.9	0.5	0.4	-0.0	0.5
Back pain experienced in last month	0.3	0.4	1.5	-0.6	-0.2	-0.5	-1.2	-0.0	-0.2	-0.7
Wears glasses or contact lenses	0.3	0.4	1.1	-0.0	0.5	-0.1	1.1	0.6	0.7	0.6
Financial situation satisfaction	0.3	0.3	0.7	-0.7	-0.3	-0.8	-0.5	-0.5	0.6	-0.4
Medication: Blood pressure	0.3	0.5	1.1	1.1	0.1	0.9	0.6	0.3	-0.7	0.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.8	-1.3	0.1	-1.2	-0.8	-0.7	0.2	-0.8
Pain experienced in last month	0.3	0.5	0.8	0.8	0.8	0.8	0.7	0.2	-0.4	0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.3	0.6	-0.4	0.8	0.9	0.8	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	-0.7	0.1	-0.4	-0.3	1.0	-0.6	-0.5
Reaction Time	0.2	0.3	1.0	0.6	0.3	0.6	0.3	-0.2	-1.0	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.3	-0.2	-0.2	-0.1	1.5	1.0	0.7	0.3
Crohns Disease (2012)	0.2	0.3	1.9	0.6	-0.0	0.3	0.0	-1.4	0.0	0.1
Lupus	0.2	0.3	1.2	0.3	0.6	0.3	-0.4	-1.1	0.2	0.7
Blood Platelet Count	0.2	2.8	7.5	1.6	-1.2	0.9	-1.8	-2.7	-1.3	1.5
Waist Hip Ratio (WHR)	0.2	0.7	1.9	-0.6	0.5	-0.4	0.8	1.4	1.2	-0.4
Cardiovascular Disease	0.2	0.7	1.3	0.9	-0.3	0.9	0.9	1.1	-1.0	0.0
Hand grip strength (left)	0.2	0.7	1.7	-1.3	-0.6	-1.3	-0.0	-0.7	0.2	-0.6
Relative age of first facial hair	0.2	0.4	0.7	-0.8	-0.0	-0.6	0.1	0.8	-0.8	-0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	0.5	0.8	0.6	-0.1	0.7	-0.2	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.1	-0.1	1.0	0.0	-0.1	0.1	0.6	0.5
Supplements: Zinc	0.2	0.2	1.4	0.0	-0.1	0.1	-0.1	-0.4	-1.2	-0.2
Average weekly fortified wine intake	0.2	0.2	0.9	0.1	-0.2	0.1	-0.9	-0.4	-0.5	-0.6
Fed-up feelings	0.2	0.4	1.3	0.0	0.8	0.3	0.7	1.2	0.4	0.3
Relative age voice broke	0.2	0.3	1.0	-0.4	0.4	-0.2	0.2	1.0	0.3	-0.5
High blood pressure	0.2	0.6	1.3	1.1	-0.4	1.0	0.6	0.4	-0.0	0.9
Sitting height	0.2	1.3	3.0	-0.7	-1.4	-0.7	-1.0	-0.8	-1.3	-1.7
Number of incorrect matches in round	0.2	0.4	1.2	0.8	0.2	0.7	0.0	-0.4	-0.0	1.1
Had menopause	0.2	0.2	1.1	0.3	-0.4	0.2	-1.1	-0.3	-0.1	0.1
Allergy	0.2	0.4	1.0	-0.8	0.2	-0.6	0.5	1.0	-0.3	-0.5
Pain all over the body in last month	0.2	0.2	0.3	-0.5	-0.3	-0.4	0.5	0.4	0.0	-0.5
Impedance of arm (right)	0.2	0.7	5.0	-0.0	-2.2	-0.1	-0.2	-0.2	0.1	0.0
Falls in the last year	0.2	0.3	0.8	0.2	-0.3	0.4	-0.9	-0.3	-0.7	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.6	-0.0	-0.6	-0.5	-0.3	0.7	-0.3
Depression (self-reported)	0.2	0.2	0.4	0.6	0.3	0.6	-0.1	-0.2	0.5	0.6
Exposure to tobacco smoke at home	0.2	0.3	1.1	0.4	1.1	0.4	-0.2	0.6	-0.3	-0.0
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.8	-0.0	0.5	-0.1	-0.2	-0.8	0.9	0.3
Exposure to tobacco smoke outside home	0.2	0.3	1.0	-0.1	1.0	0.1	-0.5	0.6	-0.7	-0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	-0.7	-0.0	-0.6	-0.0	-0.1	0.7	-0.7
Medication: Omeprazole	0.2	0.3	0.8	-0.5	0.9	-0.0	-0.1	0.5	0.1	-0.7
Overall health rating	0.2	0.4	1.3	0.8	1.1	0.8	-0.1	-0.2	0.3	0.1
Ever had bowel cancer screening	0.2	0.2	0.5	0.2	0.0	0.1	0.3	-0.5	-0.7	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.2	0.3	0.2	0.4	-0.5	0.5	0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.5	0.1	0.7	0.3	-0.7	-0.6	0.2	0.5
Medication: Aspirin	0.2	0.2	1.1	-0.2	0.2	-0.1	0.1	1.0	0.1	-0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	-0.1	0.7	0.0	-0.9	-0.6	0.4	-0.1
Arm fat-free mass (left)	0.2	0.8	2.1	1.1	1.5	1.2	0.7	-0.1	-0.5	0.4
Diastolic blood pressure, automated reading	0.2	0.7	3.2	0.1	0.1	0.1	-1.1	-0.5	-1.8	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.9	-0.7	0.5	-0.4	-0.2	0.4	-0.2	-1.0
LDL Cholesterol	0.1	0.1	0.2	0.3	0.5	0.2	0.2	-0.2	0.3	-0.3
Neuroticism	0.1	0.4	0.9	-0.7	0.8	-0.3	0.1	0.9	-0.3	-0.5
Chronotype (morning person)	0.1	0.3	1.3	0.0	0.1	-0.2	-0.2	-1.1	0.8	0.2
Hair Pigment	0.1	1.9	4.0	0.6	1.8	0.6	1.8	2.0	1.2	0.5
Medication: Co-codamol	0.1	0.1	0.5	0.0	0.3	0.1	-0.7	-0.2	-0.3	-0.4
Impedance of leg (right)	0.1	0.3	1.4	0.3	-1.2	0.4	-0.7	-0.1	-0.4	0.5
Leg fat-free mass (left)	0.1	0.4	1.2	0.7	0.9	0.7	1.1	0.2	-0.3	-0.1
Qualifications: CSEs or equivalent	0.1	0.2	1.3	-0.0	-0.1	-0.0	-1.1	-0.2	0.1	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	-0.0	-0.8	-0.1	-0.6	-0.8	0.2	-0.5
High blood pressure (mother)	0.1	0.2	0.5	0.3	0.6	0.1	0.1	-0.7	0.3	0.5
Impedance of leg (left)	0.1	0.3	1.1	0.2	-1.0	0.5	-0.5	0.4	-0.0	0.4
Leg predicted mass (left)	0.1	0.5	1.2	0.7	0.9	0.7	1.1	0.2	-0.3	-0.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.6	0.5	-0.8	0.2	-0.1	-0.4	-0.1	0.4
Trunk fat-free mass	0.1	0.4	1.0	0.6	1.0	0.7	0.9	0.1	-0.5	-0.1
Illnesses of mother	0.1	0.2	0.3	0.4	-0.6	0.5	0.1	0.4	0.5	0.0
Impedance of arm (left)	0.1	0.5	2.9	0.2	-1.7	0.3	-0.1	0.3	0.0	0.3
Trunk predicted mass	0.1	0.4	0.9	0.7	0.9	0.7	0.8	0.0	-0.5	-0.1
Breastfed as a baby	0.1	0.2	0.4	0.4	-0.3	0.4	0.3	0.7	0.6	0.2
Arm fat-free mass (right)	0.1	0.6	1.8	0.8	1.3	0.9	0.6	0.2	-0.5	0.1
Arm predicted mass (right)	0.1	0.5	1.9	0.5	1.4	0.6	0.5	0.2	-0.6	-0.2
Comparative height size at age 10	0.1	0.3	1.5	0.5	-0.4	0.4	-0.4	-1.2	-0.4	0.0
Medication: Aspirin	0.1	0.1	0.5	-0.2	0.3	-0.1	-0.1	0.7	-0.1	-0.5
Supplements: Vitamin C	0.1	0.1	0.4	-0.1	-0.6	0.2	-0.1	0.5	-0.5	-0.4
Whole body fat-free mass	0.1	0.4	1.1	0.6	1.1	0.6	0.8	0.1	-0.5	-0.2
Leg fat-free mass (right)	0.1	0.4	1.4	0.4	0.9	0.5	1.2	0.5	-0.2	-0.3
Loneliness, isolation	0.1	0.2	0.7	-0.0	-0.2	0.3	0.1	0.8	-0.5	0.2
Osteoporosis (self-reported)	0.1	0.1	0.5	-0.1	-0.7	-0.1	-0.1	0.1	0.2	-0.3
Whole body water mass	0.1	0.5	1.2	0.7	1.1	0.7	0.8	0.1	-0.5	-0.1
Leg predicted mass (right)	0.1	0.5	1.4	0.3	1.0	0.4	1.2	0.5	-0.2	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.5	0.3	-0.4	0.3	0.2	0.1	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	-0.6	0.2	-0.5	-0.2	-0.4	-0.1	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.7	-0.1	-0.8	-0.2	0.1	-0.1	-0.8	-0.1
Medication: Lisinopril	0.1	0.1	0.5	0.3	-0.2	0.0	-0.1	-0.7	-0.1	0.6
Basal metabolic rate	0.1	0.7	1.6	0.9	1.2	0.9	1.1	0.3	-0.4	0.1
Risk taking	0.1	0.1	0.2	0.1	0.2	-0.2	0.3	-0.3	-0.5	0.1
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.3	-0.0	-0.1	0.4	0.5	0.2	-0.4
Impedance of whole body	0.1	0.5	2.9	-0.0	-1.7	0.1	-0.5	-0.0	0.1	0.2
Arm predicted mass (left)	0.1	0.7	1.5	1.1	1.2	1.1	0.7	-0.2	-0.5	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.3	0.7	0.6	-0.6	0.9	0.6	0.1	0.3	-0.3
Tanning	0.0	0.3	1.3	-0.5	-1.1	-0.6	0.1	0.1	0.0	-0.5
Had other major operations	0.0	0.0	0.1	0.1	0.1	0.2	0.2	0.0	0.0	-0.1
Number of live births	0.0	0.1	0.2	0.2	-0.1	0.3	0.5	-0.1	0.2	0.2
Standing height	0.0	0.3	1.1	-0.0	-1.0	0.2	0.7	0.1	-0.5	-0.8
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.4	-0.1	0.4	0.2	0.0	-0.4	0.1

Hub : Genes

PSMB5

Models

Trait associations