Hub : Genes

EFS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1940 0.0340 6.9e-13 0.181 0.137 0.168 0.181 0.180 1.7e-21 2.5e-16 5.8e-20 1.6e-21 1.9e-21
2 TCGA Head and Neck Squamous Cell Carcinoma 0.0474 0.0238 8.5e-03 0.040 0.015 0.028 NA 0.033 2.2e-05 6.9e-03 4.0e-04 NA 1.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.2 0.2 0.5 -0.2
Bipolar Disorder or Schizophrenia 0.5 1.1 1.4 -1.2 0.9
Depressed Affect (Nagel 2018) 4.5 9.4 11.3 3.4 -2.7
Depression (Nagel 2018) 2.8 4.2 4.3 2.1 -2.0
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.0 -0.7 1.0
Neuroticism (Nagel 2018) 3.3 7.8 8.2 2.9 -2.7
Schizophrenia (2018) 1.3 2.7 3.6 -1.9 1.4
Schizophrenia vs Biploar Disorder 0.9 1.2 2.1 -0.6 1.5
Worry (Nagel 2018) 1.9 4.1 6.0 1.5 -2.4
Alzheimer’s Disease (in mother) 1.1 1.3 2.0 1.4 -0.8
Alzheimer’s Disease (in father) 1.4 1.5 2.9 -1.7 -0.3
Alzheimer’s Disease (including proxy) 0.6 0.8 1.0 0.8 -1.0
Crohns Disease (2017) 0.6 1.4 1.8 -1.4 0.9
Irritable Bowel Disease (IBD) 0.3 0.8 0.8 -0.9 0.8
Ulcerative Colitis (UC) 0.1 0.1 0.2 -0.2 0.5
Major Depression (MDD) 0.7 0.9 1.8 1.3 0.0
Reaction Time 0.2 0.4 0.7 0.1 -0.8
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.3 -0.4 0.5
Breast Cancer 0.3 0.7 1.1 1.0 0.6
Ovarian Cancer 0.5 0.6 0.9 0.5 -1.0
Prostate Cancer 1.0 1.4 2.3 0.7 -1.5
Age at First Birth 0.6 0.8 0.9 -0.8 1.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 0.9 1.8 -0.2 1.3
Coronary Artery Disease (CAD) 2.0 2.4 4.8 -2.2 0.2
Crohns Disease (2012) 2.0 3.3 5.9 -2.4 0.8
Mean Putamen Volume 0.4 0.5 1.0 1.0 0.0
Fasting Glucose 0.3 0.4 0.7 0.2 -0.8
HbA1C 0.6 0.6 1.0 0.5 -1.0
HDL Cholesterol 0.2 0.3 0.6 -0.8 0.3
LDL Cholesterol 0.1 0.2 0.4 0.2 -0.6
Lupus 0.2 0.3 0.5 0.7 -0.4
Neuroticism (2016) 0.6 0.9 1.7 1.3 0.3
Primary Biliary Cirrhosis 0.8 1.1 2.0 0.5 -1.4
Rheumatoid Arthritis 1.5 2.1 2.5 -1.6 1.3
Schizophrenia (2014) 0.7 1.6 2.9 -1.7 0.5
Triglycerides 0.3 0.5 0.9 0.9 0.1
Type 2 Diabetes (T2D) (2012) 1.8 2.1 3.5 1.9 -0.9
Ulcerative Colitis 0.2 0.3 0.6 -0.8 0.0
Blood Eosinophil Count 1.3 10.1 12.9 -3.6 2.7
Blood Platelet Count 0.4 4.3 7.6 -2.8 1.0
Blood Red Count 0.2 2.0 2.1 1.4 -1.4
Blood White Count 0.0 0.1 0.2 -0.1 0.5
Heel T-Score 0.0 0.1 0.1 -0.4 -0.0
BMI 0.5 2.8 5.1 0.6 -2.3
Height 0.3 5.8 9.1 1.6 3.0
Waist Hip Ratio (WHR) 1.8 8.2 9.2 2.7 -3.0
Systolic Blood Pressure 0.7 3.3 5.6 -1.0 2.4
Smoking Status 0.5 1.3 2.4 1.5 -0.4
Allergy or Eczema 0.1 0.3 0.6 0.2 0.8
Cardiovascular Disease 0.0 0.1 0.3 -0.1 0.5
Hypothyroidism (self reported) 0.1 0.2 0.4 0.6 -0.1
Respiratory disease 0.2 0.4 0.6 -0.8 0.5
Type 2 Diabetes (T2D) (2018) 3.6 6.8 9.7 2.0 -3.1
Lung FEV1/FVC ratio 0.7 3.8 3.9 -1.9 2.0
Lung FVC 1.7 8.7 12.0 3.5 -2.3
Neuroticism 4.1 9.8 10.7 3.0 -3.3
Chronotype (morning person) 0.2 0.4 0.8 -0.9 -0.2
Hair Pigment 0.0 0.3 0.4 -0.4 -0.7
Tanning 0.0 0.5 0.6 -0.8 0.6
Hand grip strength (left) 0.6 1.7 2.6 -0.8 1.6
Number of treatments/medications taken 0.0 0.1 0.1 -0.0 -0.4
Average weekly spirits intake 0.3 0.3 0.6 -0.2 -0.8
Sensitivity / hurt feelings 2.1 3.7 3.8 1.9 -1.9
Frequency of depressed mood in last 2 weeks 5.3 7.4 7.8 2.8 -2.6
Hearing difficulty/problems: Yes 1.1 1.7 1.8 -1.3 1.3
Relative age of first facial hair 0.6 1.3 1.4 -1.1 1.2
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.3 0.5 -0.6
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 0.3 0.6
Ever had hysterectomy (womb removed) 1.2 1.4 2.1 0.9 -1.4
Systolic blood pressure, automated reading 1.5 4.4 5.3 -1.9 2.3
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.6 1.3 0.5
Angina 0.3 0.4 0.5 -0.6 0.7
Medication for hormone replacement therapy 0.5 0.5 1.0 1.0 0.3
Vitamin and mineral supplements 0.2 0.2 0.3 -0.5 0.4
Supplements: Zinc 0.0 0.0 0.1 -0.3 -0.2
Medication: Co-codamol 0.4 0.4 0.5 -0.6 0.7
Medication: Metformin 0.9 1.3 1.7 1.3 -0.9
Diabetes (father) 3.8 4.7 9.5 -3.1 0.1
Diabetes (mother) 1.6 2.0 3.9 -0.3 -2.0
Severe depression (siblings) 2.2 2.4 3.3 1.8 -1.3
Pack years adult smoking proportion 1.0 1.5 2.5 0.7 -1.6
Impedance of leg (right) 0.0 0.1 0.3 0.5 0.0
Leg fat-free mass (left) 0.0 0.2 0.2 0.5 0.3
Trunk fat percentage 0.4 1.5 1.8 1.1 -1.3
Hand grip strength (right) 0.2 0.5 0.8 0.9 0.4
Townsend deprivation index at recruitment 1.6 2.3 2.5 1.4 -1.6
Current tobacco smoking 1.3 2.1 3.8 2.0 -0.6
Average weekly fortified wine intake 0.2 0.2 0.3 -0.3 -0.6
Maternal smoking around birth 2.5 3.7 5.1 2.3 -1.5
Fed-up feelings 3.8 6.9 7.5 2.5 -2.7
Frequency of unenthusiasm / disinterest in last 2 weeks 3.8 5.0 5.7 2.1 -2.4
Relative age voice broke 0.2 0.4 0.7 -0.8 -0.2
Taking other prescription medications 0.1 0.1 0.1 -0.2 0.3
Age when periods started (menarche) 1.1 2.6 3.8 -1.1 2.0
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.0 -0.2 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.3 -1.1 -0.8
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 0.8 -0.6 0.9
Qualifications: CSEs or equivalent 2.9 3.8 7.0 0.8 -2.6
Serious illness, injury or assault to yourself 0.4 0.4 0.5 0.7 -0.6
High blood pressure 0.1 0.2 0.3 -0.6 -0.4
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.2 0.4 0.5
Multivitamins +/- minerals 1.3 1.6 1.9 1.4 -1.2
Stomach or abdominal pain in last month 6.7 8.3 13.0 1.9 -3.6
Supplements: Glucosamine 0.1 0.2 0.3 0.0 0.6
Diverticular disease/diverticulitis (self-reported) 5.7 6.7 10.0 3.2 -1.9
Medication: Atenolol 1.3 1.6 3.1 -1.7 0.4
Medication: Levothyroxine sodium 0.0 0.0 0.0 -0.2 0.2
Sitting height 0.5 3.3 5.8 -0.9 2.4
Chronic bronchitis/emphysema (father) 0.8 1.0 1.3 0.9 -1.1
High blood pressure (mother) 4.7 6.6 6.9 -2.6 2.5
Body mass index (BMI) 0.1 0.3 0.7 -0.1 -0.8
Impedance of leg (left) 0.1 0.7 0.9 0.9 -0.7
Leg predicted mass (left) 0.0 0.1 0.1 0.3 0.4
Trunk fat mass 0.2 0.7 0.9 0.9 -0.7
Waist circumference 0.4 1.5 1.8 1.4 -1.1
Number of incorrect matches in round 0.1 0.1 0.2 0.1 0.4
Past tobacco smoking 0.4 0.7 0.9 -0.7 1.0
Alcohol usually taken with meals 0.4 0.7 0.9 0.7 1.0
Nervous feelings 2.8 5.2 8.6 1.4 -2.9
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.4 4.2 2.0 -0.8
Hearing difficulty/problems with background noise 0.7 1.1 1.1 -1.1 1.0
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.4 0.1
Had menopause 3.5 4.4 6.9 -1.4 2.6
Had other major operations 0.2 0.2 0.4 0.7 0.2
Forced vital capacity (FVC) 1.2 4.7 7.5 2.7 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 3.7 -0.3 -1.9
Ever unenthusiastic/disinterested for a whole week 2.4 2.9 3.6 1.9 -1.5
Qualifications: None of the above 0.1 0.3 0.5 0.7 0.0
Financial difficulties in last 2 years 2.3 3.1 5.4 0.9 -2.3
Mouth/teeth dental problems 0.9 1.3 1.6 -1.3 1.0
Heart attack 0.6 0.7 1.2 -0.4 -1.1
Allergy 0.1 0.2 0.2 -0.2 -0.5
Pain all over the body in last month 0.5 0.5 0.8 0.5 -0.9
Diabetes (self-reported) 1.3 1.9 2.5 1.6 -1.2
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.6 -0.5 0.8
Medication: Ramipril 0.6 0.7 1.1 0.6 -1.1
Medication: Simvastatin 0.0 0.1 0.1 0.3 0.2
Fluid intelligence score 0.0 0.0 0.0 0.1 -0.1
Illnesses of siblings 1.0 1.5 2.9 1.7 -0.1
Neuroticism score 4.8 10.0 11.7 2.9 -3.4
Weight 0.1 0.3 0.6 0.8 0.0
Impedance of arm (right) 0.1 0.4 0.8 0.9 0.1
Arm fat percentage (right) 0.0 0.1 0.2 -0.4 -0.2
Trunk fat-free mass 0.2 1.2 2.4 -0.2 1.6
Hip circumference 0.2 0.8 1.5 -0.2 1.2
Time employed in main current job 2.3 2.7 5.3 0.2 2.3
Alcohol intake versus 10 years previously 0.2 0.3 0.6 0.2 -0.7
Father’s age at death 0.6 0.8 1.3 -1.1 0.5
Worrier / anxious feelings 0.7 1.2 2.4 -0.3 -1.5
Frequency of tiredness / lethargy in last 2 weeks 2.8 4.6 5.4 1.9 -2.3
Falls in the last year 3.0 4.1 7.4 0.9 -2.7
Hair/balding pattern: Pattern 3 1.7 2.5 4.7 -0.5 2.2
Number of live births 1.8 2.5 2.9 1.4 -1.7
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 4.0 2.0 -1.1
Pulse rate 8.7 14.7 22.5 2.6 -4.7
Happiness 1.1 1.3 2.1 0.7 -1.5
Noisy workplace 0.5 0.6 0.6 -0.8 0.8
Qualifications: A levels/AS levels or equivalent 1.1 2.4 4.7 -2.2 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.1 0.1 0.2
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 0.2 0.4
Asthma 0.1 0.1 0.1 -0.3 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.2 0.2 -1.1
Medication: Cholesterol lowering 0.2 0.4 0.6 -0.8 -0.3
Depression (self-reported) 0.0 0.0 0.0 0.1 -0.2
Medication: Lansoprazole 2.2 2.5 3.6 -1.9 -1.2
Prospective memory result 1.2 1.5 1.7 -1.1 1.3
Lung cancer (father) 0.3 0.3 0.5 0.5 0.7
Illnesses of mother 0.8 1.0 1.1 0.9 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 4.5 2.1 -0.5
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 0.4 -0.6
Impedance of arm (left) 0.6 2.7 4.5 2.1 -1.0
Arm fat mass (right) 0.0 0.1 0.1 0.2 -0.4
Trunk predicted mass 0.2 1.1 2.2 -0.2 1.5
Standing height 0.3 3.3 3.9 1.6 2.0
Length of working week for main job 1.9 2.1 2.3 1.4 -1.5
Exposure to tobacco smoke at home 0.2 0.3 0.3 -0.6 0.4
Breastfed as a baby 0.3 0.4 0.6 0.8 0.5
Tense / ‘highly strung’ 1.9 3.1 4.7 2.2 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 0.9 0.8 -0.9
Hair/balding pattern: Pattern 4 1.6 3.9 4.1 -1.9 2.0
Birth weight of first child 0.0 0.1 0.1 0.4 -0.1
Peak expiratory flow (PEF) 1.0 2.3 2.8 1.7 -1.4
Pulse wave reflection index 1.0 1.2 1.6 -1.3 0.9
Ever highly irritable/argumentative for 2 days 1.4 1.7 3.1 1.8 -0.5
Loud music exposure frequency 0.4 0.5 0.5 -0.7 0.7
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 1.8 -1.3 -1.0
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 3.6 0.8 -1.9
Blood clot in the leg (DVT) 0.1 0.1 0.1 0.4 -0.2
Medication: Paracetamol 1.0 1.6 2.0 1.1 -1.4
Headache pain in last month 1.9 3.2 5.3 1.1 -2.3
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 1.0 1.0 -0.4
Glaucoma (self-reported) 0.8 0.9 1.7 -0.3 -1.3
Gout (self-reported) 1.2 1.7 2.2 -1.5 1.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.1 0.3 -0.3
Medication: Amlodipine 0.1 0.1 0.3 0.5 -0.0
Medication: Ventolin 100micrograms inhaler 1.4 1.7 2.7 -0.9 1.7
Birth weight 0.3 0.7 1.4 1.2 -0.1
Chronic bronchitis/emphysema (mother) 4.7 5.5 7.4 2.7 -1.9
High blood pressure (siblings) 0.5 0.7 1.2 -1.1 0.4
Forced vital capacity (FVC), Best measure 1.2 4.5 8.1 2.8 -1.0
Body fat percentage 0.3 1.3 1.8 0.8 -1.3
Leg fat percentage (right) 0.1 0.5 1.1 0.1 -1.0
Arm fat-free mass (right) 0.0 0.1 0.2 0.3 0.4
Exposure to tobacco smoke outside home 3.5 4.7 5.3 2.0 -2.3
Comparative body size at age 10 0.0 0.0 0.1 -0.2 -0.0
Number of full brothers 0.5 0.6 1.0 -1.0 -0.5
Worry too long after embarrassment 0.8 1.4 2.8 0.2 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 0.8 -0.9 0.7
Wheeze or whistling in the chest in last year 0.6 1.0 1.1 1.0 -1.0
Number of children fathered 1.1 1.3 1.8 0.8 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 1.5 0.5 1.2
Age at first live birth 0.1 0.1 0.2 -0.5 0.2
Pulse wave peak to peak time 0.3 0.3 0.7 -0.1 0.8
Health satisfaction 2.4 3.1 5.0 1.0 -2.2
Shortness of breath walking on level ground 0.4 0.5 0.7 -0.5 -0.9
Qualifications: College or University degree 1.3 4.2 4.6 -1.9 2.1
Eye problems/disorders: None of the above 0.0 0.0 0.0 0.2 -0.2
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.1 0.2 0.1
Emphysema/chronic bronchitis 0.1 0.2 0.3 0.3 0.5
Medication for pain relief, constipation, heartburn 1.3 2.2 3.9 -0.6 2.0
Neck or shoulder pain in last month 1.8 2.5 3.2 1.3 -1.8
Medication: Blood pressure 0.5 0.8 1.3 -1.2 0.6
Angina (self-reported) 0.2 0.2 0.3 -0.5 0.4
Migraine (self-reported) 0.6 0.7 0.7 0.8 0.9
Medication: Ibuprofen 0.5 0.6 1.0 0.6 -1.0
Medication: Allopurinol 1.0 1.4 1.9 -0.9 1.4
Medication: Omeprazole 3.8 4.5 5.1 2.0 -2.2
Medication: Seretide 50 evohaler 0.7 0.9 1.6 1.3 0.4
Mean time to correctly identify matches 0.5 0.9 1.8 0.1 -1.3
Heart disease (mother) 0.1 0.1 0.1 -0.3 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 0.3 -0.1
Whole body fat mass 0.1 0.6 0.6 0.8 -0.7
Leg fat mass (right) 0.0 0.1 0.2 0.2 -0.4
Arm predicted mass (right) 0.0 0.1 0.2 0.5 0.1
Pulse rate, automated reading 23.2 75.1 127.7 4.7 -11.3
Alcohol intake frequency. 1.3 3.1 3.2 1.8 -1.7
Comparative height size at age 10 0.1 0.4 0.7 0.9 -0.2
Number of full sisters 1.5 1.8 2.1 1.5 -1.2
Suffer from ‘nerves’ 2.4 3.7 4.8 1.6 -2.2
Overall health rating 1.9 4.1 7.8 0.7 -2.8
Chest pain or discomfort 1.1 1.7 3.3 0.2 -1.8
Had major operations 0.9 1.0 1.3 1.2 -0.8
Age at last live birth 0.4 0.6 0.6 -0.7 0.8
Family relationship satisfaction 0.9 1.1 2.0 1.4 -0.5
Leg pain on walking 0.3 0.3 0.5 -0.7 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.6 -0.8 0.6
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.3 0.3 1.2
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 -0.3 1.0
Medication: Aspirin 0.8 1.1 2.0 -1.4 0.4
Supplements: Vitamin C 0.0 0.0 0.0 0.0 0.2
Knee pain experienced in last month 1.1 1.7 2.2 -1.1 1.5
Hypertension (Self-reported) 0.1 0.2 0.5 -0.7 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 -0.4 0.1
Illnesses of father: Heart disease 0.3 0.4 0.7 -0.9 0.1
Illnesses of siblings: Diabetes 0.2 0.3 0.4 -0.3 -0.6
Smoking status: Previous 0.3 0.4 0.8 -0.2 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.2 0.5 0.4
Whole body fat-free mass 0.1 0.4 0.9 0.0 0.9
Leg fat-free mass (right) 0.0 0.2 0.4 0.6 -0.1
Arm fat percentage (left) 0.1 0.4 0.7 0.2 -0.8
Average weekly red wine intake 0.3 0.4 0.6 -0.8 0.4
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.3 -0.4 0.5
Mood swings 2.9 5.3 5.5 2.3 -2.3
Loneliness, isolation 9.6 13.2 13.5 3.6 -3.7
Long-standing illness, disability or infirmity 1.4 2.1 3.1 1.0 -1.8
Ever had bowel cancer screening 0.2 0.3 0.3 0.6 0.4
Diabetes diagnosed by doctor 2.0 3.4 3.5 1.8 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.3 -0.3 -0.6
Friendships satisfaction 3.9 4.8 5.1 2.1 -2.2
Qualifications: nursing, teaching 0.0 0.0 0.0 0.1 -0.1
Commuting to job workplace: Walk 0.1 0.1 0.1 0.2 -0.3
Eye problems/disorders: Cataract 0.7 0.8 1.3 1.1 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.0 0.2 -1.0
Medication for cholesterol 0.0 0.0 0.1 0.3 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.4 -0.4 -0.7
Back pain experienced in last month 0.6 0.9 1.2 1.1 -0.8
Mineral and other dietary supplements 0.1 0.2 0.3 -0.0 -0.6
Breast cancer (self-reported) 0.3 0.3 0.5 -0.4 0.7
Asthma (self-reported) 0.2 0.4 0.6 -0.8 0.4
Osteoporosis (self-reported) 0.1 0.2 0.3 -0.6 -0.0
Osteoarthritis (self-reported) 0.1 0.1 0.2 0.4 0.1
Medication: Aspirin 1.2 1.6 3.1 -1.8 0.3
Medication: Gliclazide 1.6 1.8 2.4 1.1 -1.6
Illnesses of father: None of the above (group 1) 1.8 2.2 4.1 2.0 -0.6
Smoking status: Current 1.2 1.8 3.6 1.9 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 2.8 1.7 -0.0
Whole body water mass 0.1 0.4 0.8 0.1 0.9
Leg predicted mass (right) 0.0 0.2 0.4 0.7 0.0
Arm fat mass (left) 0.0 0.2 0.2 0.4 -0.5
Number of self-reported non-cancer illnesses 0.1 0.2 0.3 0.5 0.2
Average weekly champagne plus white wine intake 4.4 6.0 8.2 -2.0 2.9
Miserableness 3.2 5.5 8.1 2.8 -1.7
Guilty feelings 2.6 4.0 5.3 2.3 -1.6
Wears glasses or contact lenses 0.2 0.2 0.4 -0.6 -0.1
Ever taken oral contraceptive pill 1.3 1.4 2.4 -1.6 -0.6
Hearing aid user 0.5 0.6 0.9 1.0 0.5
Mother’s age at death 0.1 0.1 0.3 0.5 -0.0
Financial situation satisfaction 3.2 3.9 6.0 1.4 -2.5
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.7 0.3 0.8
Commuting to job workplace: Public transport 0.4 0.5 0.8 -0.9 -0.4
Eye problems/disorders: Glaucoma 1.0 1.2 2.3 -0.3 -1.5
Medication: Blood pressure 0.1 0.2 0.3 0.2 -0.6
Pain type(s) experienced in last month: Hip pain 2.7 3.3 4.9 2.2 -1.3
Supplements: Fish oil (including cod liver oil) 0.9 1.2 1.7 -0.8 1.3
High cholesterol (Self-reported) 0.1 0.2 0.3 -0.3 0.6
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.2 -0.5
Medication: Paracetamol 0.2 0.3 0.5 0.7 -0.3
Medication: Lisinopril 1.2 1.6 3.1 -0.4 1.8
Medication: Atorvastatin 0.7 0.9 1.0 -0.9 -1.0
Illnesses of father: High blood pressure 1.8 2.3 2.6 -1.4 1.6
Alcohol drinker status: Never 0.6 0.7 1.2 0.6 1.1
Ever smoked 0.5 0.9 1.2 1.1 -0.8
Basal metabolic rate 0.0 0.2 0.3 0.4 0.6
Leg fat percentage (left) 0.3 1.2 2.2 0.5 -1.5
Arm fat-free mass (left) 0.0 0.2 0.4 0.3 0.6
Number of operations (self-reported) 0.7 1.1 1.9 1.4 -0.5
Average weekly beer plus cider intake 2.1 3.0 3.7 1.5 -1.9
Irritability 1.5 2.5 3.3 1.3 -1.8
Risk taking 3.9 5.6 8.6 -1.6 2.9
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.3 0.4 -0.6
Fractured/broken bones in last 5 years 2.1 2.7 5.0 2.2 -0.6
Age started oral contraceptive pill 2.9 3.6 4.6 -2.1 1.6
Diastolic blood pressure, automated reading 1.3 3.9 6.9 1.0 -2.6
Ever depressed for a whole week 0.6 0.7 0.8 0.9 -0.8
Unable to work because of sickness or disability 5.2 6.7 9.5 2.0 -3.1
Commuting to job workplace: Cycle 0.2 0.3 0.5 -0.7 -0.3
Myopia 1.1 1.7 2.2 1.5 -1.1
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.5 0.7 0.1
Cholesterol lowering medication 0.4 0.5 0.9 1.0 -0.4
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 1.6 0.9 -1.3
Pain experienced in last month 0.1 0.2 0.3 0.3 0.6
Supplements: Calcium 1.5 1.7 2.9 -0.7 1.7
Basal cell carcinoma (self-reported) 0.2 0.3 0.3 -0.5 0.5
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.5 -0.2 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.1 0.2 0.1
Heart disease (siblings) 0.2 0.3 0.4 -0.5 0.6
Alcohol drinker status: Previous 6.0 6.9 8.6 2.3 -2.9
Pack years of smoking 0.3 0.5 0.9 0.1 -1.0
Impedance of whole body 0.4 2.2 3.1 1.8 -1.1
Leg fat mass (left) 0.0 0.1 0.2 0.2 -0.4
Arm predicted mass (left) 0.1 0.4 0.8 -0.0 0.9