TWAS hub - EFS

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1940	0.0340	6.9e-13	0.181	0.137	0.168	0.181	0.180	1.7e-21	2.5e-16	5.8e-20	1.6e-21	1.9e-21
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0474	0.0238	8.5e-03	0.040	0.015	0.028	NA	0.033	2.2e-05	6.9e-03	4.0e-04	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Pulse rate, automated reading	23.2	75.1	127.7	4.7	-11.3
Loneliness, isolation	9.6	13.2	13.5	3.6	-3.7
Pulse rate	8.7	14.7	22.5	2.6	-4.7
Stomach or abdominal pain in last month	6.7	8.3	13.0	1.9	-3.6
Alcohol drinker status: Previous	6.0	6.9	8.6	2.3	-2.9
Diverticular disease/diverticulitis (self-reported)	5.7	6.7	10.0	3.2	-1.9
Frequency of depressed mood in last 2 weeks	5.3	7.4	7.8	2.8	-2.6
Unable to work because of sickness or disability	5.2	6.7	9.5	2.0	-3.1
Neuroticism score	4.8	10.0	11.7	2.9	-3.4
High blood pressure (mother)	4.7	6.6	6.9	-2.6	2.5
Chronic bronchitis/emphysema (mother)	4.7	5.5	7.4	2.7	-1.9
Depressed Affect (Nagel 2018)	4.5	9.4	11.3	3.4	-2.7
Average weekly champagne plus white wine intake	4.4	6.0	8.2	-2.0	2.9
Neuroticism	4.1	9.8	10.7	3.0	-3.3
Friendships satisfaction	3.9	4.8	5.1	2.1	-2.2
Risk taking	3.9	5.6	8.6	-1.6	2.9
Diabetes (father)	3.8	4.7	9.5	-3.1	0.1
Fed-up feelings	3.8	6.9	7.5	2.5	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.8	5.0	5.7	2.1	-2.4
Medication: Omeprazole	3.8	4.5	5.1	2.0	-2.2
Type 2 Diabetes (T2D) (2018)	3.6	6.8	9.7	2.0	-3.1
Had menopause	3.5	4.4	6.9	-1.4	2.6
Exposure to tobacco smoke outside home	3.5	4.7	5.3	2.0	-2.3
Neuroticism (Nagel 2018)	3.3	7.8	8.2	2.9	-2.7
Miserableness	3.2	5.5	8.1	2.8	-1.7
Financial situation satisfaction	3.2	3.9	6.0	1.4	-2.5
Falls in the last year	3.0	4.1	7.4	0.9	-2.7
Qualifications: CSEs or equivalent	2.9	3.8	7.0	0.8	-2.6
Mood swings	2.9	5.3	5.5	2.3	-2.3
Age started oral contraceptive pill	2.9	3.6	4.6	-2.1	1.6
Depression (Nagel 2018)	2.8	4.2	4.3	2.1	-2.0
Nervous feelings	2.8	5.2	8.6	1.4	-2.9
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.6	5.4	1.9	-2.3
Pain type(s) experienced in last month: Hip pain	2.7	3.3	4.9	2.2	-1.3
Guilty feelings	2.6	4.0	5.3	2.3	-1.6
Maternal smoking around birth	2.5	3.7	5.1	2.3	-1.5
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	3.6	1.9	-1.5
Health satisfaction	2.4	3.1	5.0	1.0	-2.2
Suffer from ‘nerves’	2.4	3.7	4.8	1.6	-2.2
Financial difficulties in last 2 years	2.3	3.1	5.4	0.9	-2.3
Time employed in main current job	2.3	2.7	5.3	0.2	2.3
Severe depression (siblings)	2.2	2.4	3.3	1.8	-1.3
Medication: Lansoprazole	2.2	2.5	3.6	-1.9	-1.2
Sensitivity / hurt feelings	2.1	3.7	3.8	1.9	-1.9
Average weekly beer plus cider intake	2.1	3.0	3.7	1.5	-1.9
Fractured/broken bones in last 5 years	2.1	2.7	5.0	2.2	-0.6
Coronary Artery Disease (CAD)	2.0	2.4	4.8	-2.2	0.2
Crohns Disease (2012)	2.0	3.3	5.9	-2.4	0.8
Diabetes diagnosed by doctor	2.0	3.4	3.5	1.8	-1.9
Worry (Nagel 2018)	1.9	4.1	6.0	1.5	-2.4
Length of working week for main job	1.9	2.1	2.3	1.4	-1.5
Tense / ‘highly strung’	1.9	3.1	4.7	2.2	-1.2
Headache pain in last month	1.9	3.2	5.3	1.1	-2.3
Overall health rating	1.9	4.1	7.8	0.7	-2.8
Type 2 Diabetes (T2D) (2012)	1.8	2.1	3.5	1.9	-0.9
Waist Hip Ratio (WHR)	1.8	8.2	9.2	2.7	-3.0
Number of live births	1.8	2.5	2.9	1.4	-1.7
Neck or shoulder pain in last month	1.8	2.5	3.2	1.3	-1.8
Illnesses of father: None of the above (group 1)	1.8	2.2	4.1	2.0	-0.6
Illnesses of father: High blood pressure	1.8	2.3	2.6	-1.4	1.6
Lung FVC	1.7	8.7	12.0	3.5	-2.3
Hair/balding pattern: Pattern 3	1.7	2.5	4.7	-0.5	2.2
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.6	0.8	-1.9
Diabetes (mother)	1.6	2.0	3.9	-0.3	-2.0
Townsend deprivation index at recruitment	1.6	2.3	2.5	1.4	-1.6
Hair/balding pattern: Pattern 4	1.6	3.9	4.1	-1.9	2.0
Medication: Gliclazide	1.6	1.8	2.4	1.1	-1.6
Rheumatoid Arthritis	1.5	2.1	2.5	-1.6	1.3
Systolic blood pressure, automated reading	1.5	4.4	5.3	-1.9	2.3
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	4.2	2.0	-0.8
Number of full sisters	1.5	1.8	2.1	1.5	-1.2
Irritability	1.5	2.5	3.3	1.3	-1.8
Supplements: Calcium	1.5	1.7	2.9	-0.7	1.7
Alzheimer’s Disease (in father)	1.4	1.5	2.9	-1.7	-0.3
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.1	1.8	-0.5
Medication: Ventolin 100micrograms inhaler	1.4	1.7	2.7	-0.9	1.7
Long-standing illness, disability or infirmity	1.4	2.1	3.1	1.0	-1.8
Schizophrenia (2018)	1.3	2.7	3.6	-1.9	1.4
Blood Eosinophil Count	1.3	10.1	12.9	-3.6	2.7
Current tobacco smoking	1.3	2.1	3.8	2.0	-0.6
Multivitamins +/- minerals	1.3	1.6	1.9	1.4	-1.2
Medication: Atenolol	1.3	1.6	3.1	-1.7	0.4
Diabetes (self-reported)	1.3	1.9	2.5	1.6	-1.2
Qualifications: College or University degree	1.3	4.2	4.6	-1.9	2.1
Medication for pain relief, constipation, heartburn	1.3	2.2	3.9	-0.6	2.0
Alcohol intake frequency.	1.3	3.1	3.2	1.8	-1.7
Ever taken oral contraceptive pill	1.3	1.4	2.4	-1.6	-0.6
Diastolic blood pressure, automated reading	1.3	3.9	6.9	1.0	-2.6
Ever had hysterectomy (womb removed)	1.2	1.4	2.1	0.9	-1.4
Forced vital capacity (FVC)	1.2	4.7	7.5	2.7	-1.3
Prospective memory result	1.2	1.5	1.7	-1.1	1.3
Gout (self-reported)	1.2	1.7	2.2	-1.5	1.0
Forced vital capacity (FVC), Best measure	1.2	4.5	8.1	2.8	-1.0
Medication: Aspirin	1.2	1.6	3.1	-1.8	0.3
Smoking status: Current	1.2	1.8	3.6	1.9	-0.3
Medication: Lisinopril	1.2	1.6	3.1	-0.4	1.8
Alzheimer’s Disease (in mother)	1.1	1.3	2.0	1.4	-0.8
Hearing difficulty/problems: Yes	1.1	1.7	1.8	-1.3	1.3
Age when periods started (menarche)	1.1	2.6	3.8	-1.1	2.0
Happiness	1.1	1.3	2.1	0.7	-1.5
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.7	-2.2	0.3
Number of children fathered	1.1	1.3	1.8	0.8	-1.3
Chest pain or discomfort	1.1	1.7	3.3	0.2	-1.8
Knee pain experienced in last month	1.1	1.7	2.2	-1.1	1.5
Myopia	1.1	1.7	2.2	1.5	-1.1
Prostate Cancer	1.0	1.4	2.3	0.7	-1.5
Pack years adult smoking proportion	1.0	1.5	2.5	0.7	-1.6
Illnesses of siblings	1.0	1.5	2.9	1.7	-0.1
Peak expiratory flow (PEF)	1.0	2.3	2.8	1.7	-1.4
Pulse wave reflection index	1.0	1.2	1.6	-1.3	0.9
Medication: Paracetamol	1.0	1.6	2.0	1.1	-1.4
Medication: Allopurinol	1.0	1.4	1.9	-0.9	1.4
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	-0.3	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	1.6	0.9	-1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	2.1	-0.6	1.5
Medication: Metformin	0.9	1.3	1.7	1.3	-0.9
Mouth/teeth dental problems	0.9	1.3	1.6	-1.3	1.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	1.8	-1.3	-1.0
Had major operations	0.9	1.0	1.3	1.2	-0.8
Family relationship satisfaction	0.9	1.1	2.0	1.4	-0.5
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.7	-0.8	1.3
Primary Biliary Cirrhosis	0.8	1.1	2.0	0.5	-1.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.6	1.3	0.5
Chronic bronchitis/emphysema (father)	0.8	1.0	1.3	0.9	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.7	-0.3	-1.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.0	2.0	-1.1
Illnesses of mother	0.8	1.0	1.1	0.9	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	4.5	2.1	-0.5
Glaucoma (self-reported)	0.8	0.9	1.7	-0.3	-1.3
Worry too long after embarrassment	0.8	1.4	2.8	0.2	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.5	0.5	1.2
Medication: Aspirin	0.8	1.1	2.0	-1.4	0.4
Major Depression (MDD)	0.7	0.9	1.8	1.3	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	1.8	-0.2	1.3
Schizophrenia (2014)	0.7	1.6	2.9	-1.7	0.5
Systolic Blood Pressure	0.7	3.3	5.6	-1.0	2.4
Lung FEV1/FVC ratio	0.7	3.8	3.9	-1.9	2.0
Hearing difficulty/problems with background noise	0.7	1.1	1.1	-1.1	1.0
Worrier / anxious feelings	0.7	1.2	2.4	-0.3	-1.5
Medication: Seretide 50 evohaler	0.7	0.9	1.6	1.3	0.4
Eye problems/disorders: Cataract	0.7	0.8	1.3	1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.8	1.7	-0.0
Medication: Atorvastatin	0.7	0.9	1.0	-0.9	-1.0
Number of operations (self-reported)	0.7	1.1	1.9	1.4	-0.5
Alzheimer’s Disease (including proxy)	0.6	0.8	1.0	0.8	-1.0
Crohns Disease (2017)	0.6	1.4	1.8	-1.4	0.9
Age at First Birth	0.6	0.8	0.9	-0.8	1.0
HbA1C	0.6	0.6	1.0	0.5	-1.0
Neuroticism (2016)	0.6	0.9	1.7	1.3	0.3
Hand grip strength (left)	0.6	1.7	2.6	-0.8	1.6
Relative age of first facial hair	0.6	1.3	1.4	-1.1	1.2
Heart attack	0.6	0.7	1.2	-0.4	-1.1
Medication: Ramipril	0.6	0.7	1.1	0.6	-1.1
Father’s age at death	0.6	0.8	1.3	-1.1	0.5
Impedance of arm (left)	0.6	2.7	4.5	2.1	-1.0
Wheeze or whistling in the chest in last year	0.6	1.0	1.1	1.0	-1.0
Migraine (self-reported)	0.6	0.7	0.7	0.8	0.9
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	0.3	1.2
Back pain experienced in last month	0.6	0.9	1.2	1.1	-0.8
Alcohol drinker status: Never	0.6	0.7	1.2	0.6	1.1
Ever depressed for a whole week	0.6	0.7	0.8	0.9	-0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	-0.2	-1.2
Bipolar Disorder or Schizophrenia	0.5	1.1	1.4	-1.2	0.9
Ovarian Cancer	0.5	0.6	0.9	0.5	-1.0
BMI	0.5	2.8	5.1	0.6	-2.3
Smoking Status	0.5	1.3	2.4	1.5	-0.4
Medication for hormone replacement therapy	0.5	0.5	1.0	1.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	0.8	-0.6	0.9
Sitting height	0.5	3.3	5.8	-0.9	2.4
Pain all over the body in last month	0.5	0.5	0.8	0.5	-0.9
Noisy workplace	0.5	0.6	0.6	-0.8	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.2	0.2	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	0.9	0.8	-0.9
High blood pressure (siblings)	0.5	0.7	1.2	-1.1	0.4
Number of full brothers	0.5	0.6	1.0	-1.0	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.8	-0.9	0.7
Medication: Blood pressure	0.5	0.8	1.3	-1.2	0.6
Medication: Ibuprofen	0.5	0.6	1.0	0.6	-1.0
Mean time to correctly identify matches	0.5	0.9	1.8	0.1	-1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-0.3	1.0
Hearing aid user	0.5	0.6	0.9	1.0	0.5
Ever smoked	0.5	0.9	1.2	1.1	-0.8
Mean Putamen Volume	0.4	0.5	1.0	1.0	0.0
Blood Platelet Count	0.4	4.3	7.6	-2.8	1.0
Medication: Co-codamol	0.4	0.4	0.5	-0.6	0.7
Trunk fat percentage	0.4	1.5	1.8	1.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.3	-1.1	-0.8
Serious illness, injury or assault to yourself	0.4	0.4	0.5	0.7	-0.6
Waist circumference	0.4	1.5	1.8	1.4	-1.1
Past tobacco smoking	0.4	0.7	0.9	-0.7	1.0
Alcohol usually taken with meals	0.4	0.7	0.9	0.7	1.0
Loud music exposure frequency	0.4	0.5	0.5	-0.7	0.7
Shortness of breath walking on level ground	0.4	0.5	0.7	-0.5	-0.9
Age at last live birth	0.4	0.6	0.6	-0.7	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.6	-0.8	0.6
Commuting to job workplace: Public transport	0.4	0.5	0.8	-0.9	-0.4
Cholesterol lowering medication	0.4	0.5	0.9	1.0	-0.4
Impedance of whole body	0.4	2.2	3.1	1.8	-1.1
Irritable Bowel Disease (IBD)	0.3	0.8	0.8	-0.9	0.8
Breast Cancer	0.3	0.7	1.1	1.0	0.6
Fasting Glucose	0.3	0.4	0.7	0.2	-0.8
Triglycerides	0.3	0.5	0.9	0.9	0.1
Height	0.3	5.8	9.1	1.6	3.0
Average weekly spirits intake	0.3	0.3	0.6	-0.2	-0.8
Angina	0.3	0.4	0.5	-0.6	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	-0.5	0.8
Lung cancer (father)	0.3	0.3	0.5	0.5	0.7
Standing height	0.3	3.3	3.9	1.6	2.0
Breastfed as a baby	0.3	0.4	0.6	0.8	0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.0	1.0	-0.4
Birth weight	0.3	0.7	1.4	1.2	-0.1
Body fat percentage	0.3	1.3	1.8	0.8	-1.3
Pulse wave peak to peak time	0.3	0.3	0.7	-0.1	0.8
Leg pain on walking	0.3	0.3	0.5	-0.7	-0.4
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.9	0.1
Smoking status: Previous	0.3	0.4	0.8	-0.2	-0.9
Average weekly red wine intake	0.3	0.4	0.6	-0.8	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	0.2	-1.0
Breast cancer (self-reported)	0.3	0.3	0.5	-0.4	0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	0.3	0.8
Leg fat percentage (left)	0.3	1.2	2.2	0.5	-1.5
Pack years of smoking	0.3	0.5	0.9	0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.0	-0.7	1.0
Reaction Time	0.2	0.4	0.7	0.1	-0.8
HDL Cholesterol	0.2	0.3	0.6	-0.8	0.3
Lupus	0.2	0.3	0.5	0.7	-0.4
Ulcerative Colitis	0.2	0.3	0.6	-0.8	0.0
Blood Red Count	0.2	2.0	2.1	1.4	-1.4
Respiratory disease	0.2	0.4	0.6	-0.8	0.5
Chronotype (morning person)	0.2	0.4	0.8	-0.9	-0.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.3	0.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	0.3	0.6
Vitamin and mineral supplements	0.2	0.2	0.3	-0.5	0.4
Hand grip strength (right)	0.2	0.5	0.8	0.9	0.4
Average weekly fortified wine intake	0.2	0.2	0.3	-0.3	-0.6
Relative age voice broke	0.2	0.4	0.7	-0.8	-0.2
Trunk fat mass	0.2	0.7	0.9	0.9	-0.7
Had other major operations	0.2	0.2	0.4	0.7	0.2
Trunk fat-free mass	0.2	1.2	2.4	-0.2	1.6
Hip circumference	0.2	0.8	1.5	-0.2	1.2
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.2	-0.7
Medication: Cholesterol lowering	0.2	0.4	0.6	-0.8	-0.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.4	-0.6
Trunk predicted mass	0.2	1.1	2.2	-0.2	1.5
Exposure to tobacco smoke at home	0.2	0.3	0.3	-0.6	0.4
Angina (self-reported)	0.2	0.2	0.3	-0.5	0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.4	-0.3	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.4	0.5
Ever had bowel cancer screening	0.2	0.3	0.3	0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.4	-0.4	-0.7
Asthma (self-reported)	0.2	0.4	0.6	-0.8	0.4
Wears glasses or contact lenses	0.2	0.2	0.4	-0.6	-0.1
Medication: Paracetamol	0.2	0.3	0.5	0.7	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	0.4	-0.6
Commuting to job workplace: Cycle	0.2	0.3	0.5	-0.7	-0.3
Basal cell carcinoma (self-reported)	0.2	0.3	0.3	-0.5	0.5
Heart disease (siblings)	0.2	0.3	0.4	-0.5	0.6
Bipolar Disorder (2018)	0.1	0.2	0.2	0.5	-0.2
Ulcerative Colitis (UC)	0.1	0.1	0.2	-0.2	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.4	0.5
LDL Cholesterol	0.1	0.2	0.4	0.2	-0.6
Allergy or Eczema	0.1	0.3	0.6	0.2	0.8
Hypothyroidism (self reported)	0.1	0.2	0.4	0.6	-0.1
Taking other prescription medications	0.1	0.1	0.1	-0.2	0.3
High blood pressure	0.1	0.2	0.3	-0.6	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.2	0.4	0.5
Supplements: Glucosamine	0.1	0.2	0.3	0.0	0.6
Body mass index (BMI)	0.1	0.3	0.7	-0.1	-0.8
Impedance of leg (left)	0.1	0.7	0.9	0.9	-0.7
Number of incorrect matches in round	0.1	0.1	0.2	0.1	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.4	0.1
Qualifications: None of the above	0.1	0.3	0.5	0.7	0.0
Allergy	0.1	0.2	0.2	-0.2	-0.5
Weight	0.1	0.3	0.6	0.8	0.0
Impedance of arm (right)	0.1	0.4	0.8	0.9	0.1
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.2	0.4
Asthma	0.1	0.1	0.1	-0.3	0.4
Blood clot in the leg (DVT)	0.1	0.1	0.1	0.4	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.1	0.3	-0.3
Medication: Amlodipine	0.1	0.1	0.3	0.5	-0.0
Leg fat percentage (right)	0.1	0.5	1.1	0.1	-1.0
Age at first live birth	0.1	0.1	0.2	-0.5	0.2
Emphysema/chronic bronchitis	0.1	0.2	0.3	0.3	0.5
Heart disease (mother)	0.1	0.1	0.1	-0.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.3	-0.1
Whole body fat mass	0.1	0.6	0.6	0.8	-0.7
Comparative height size at age 10	0.1	0.4	0.7	0.9	-0.2
Hypertension (Self-reported)	0.1	0.2	0.5	-0.7	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.2	0.5	0.4
Whole body fat-free mass	0.1	0.4	0.9	0.0	0.9
Arm fat percentage (left)	0.1	0.4	0.7	0.2	-0.8
Commuting to job workplace: Walk	0.1	0.1	0.1	0.2	-0.3
Mineral and other dietary supplements	0.1	0.2	0.3	-0.0	-0.6
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.6	-0.0
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.4	0.1
Whole body water mass	0.1	0.4	0.8	0.1	0.9
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	0.5	0.2
Mother’s age at death	0.1	0.1	0.3	0.5	-0.0
Medication: Blood pressure	0.1	0.2	0.3	0.2	-0.6
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.3	0.6
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.2	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	0.7	0.1
Pain experienced in last month	0.1	0.2	0.3	0.3	0.6
Arm predicted mass (left)	0.1	0.4	0.8	-0.0	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.1	0.2	-0.1	0.5
Heel T-Score	0.0	0.1	0.1	-0.4	-0.0
Cardiovascular Disease	0.0	0.1	0.3	-0.1	0.5
Hair Pigment	0.0	0.3	0.4	-0.4	-0.7
Tanning	0.0	0.5	0.6	-0.8	0.6
Number of treatments/medications taken	0.0	0.1	0.1	-0.0	-0.4
Supplements: Zinc	0.0	0.0	0.1	-0.3	-0.2
Impedance of leg (right)	0.0	0.1	0.3	0.5	0.0
Leg fat-free mass (left)	0.0	0.2	0.2	0.5	0.3
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	-0.2	-0.1
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.2	0.2
Leg predicted mass (left)	0.0	0.1	0.1	0.3	0.4
Medication: Simvastatin	0.0	0.1	0.1	0.3	0.2
Fluid intelligence score	0.0	0.0	0.0	0.1	-0.1
Arm fat percentage (right)	0.0	0.1	0.2	-0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.1	0.2
Depression (self-reported)	0.0	0.0	0.0	0.1	-0.2
Arm fat mass (right)	0.0	0.1	0.1	0.2	-0.4
Birth weight of first child	0.0	0.1	0.1	0.4	-0.1
Arm fat-free mass (right)	0.0	0.1	0.2	0.3	0.4
Comparative body size at age 10	0.0	0.0	0.1	-0.2	-0.0
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.2	0.1
Leg fat mass (right)	0.0	0.1	0.2	0.2	-0.4
Arm predicted mass (right)	0.0	0.1	0.2	0.5	0.1
Supplements: Vitamin C	0.0	0.0	0.0	0.0	0.2
Leg fat-free mass (right)	0.0	0.2	0.4	0.6	-0.1
Qualifications: nursing, teaching	0.0	0.0	0.0	0.1	-0.1
Medication for cholesterol	0.0	0.0	0.1	0.3	0.1
Leg predicted mass (right)	0.0	0.2	0.4	0.7	0.0
Arm fat mass (left)	0.0	0.2	0.2	0.4	-0.5
Basal metabolic rate	0.0	0.2	0.3	0.4	0.6
Arm fat-free mass (left)	0.0	0.2	0.4	0.3	0.6
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.2	0.1
Leg fat mass (left)	0.0	0.1	0.2	0.2	-0.4

Hub : Genes

EFS

Models

Trait associations