[Hub]/) : Traits : Gout (self-reported) :

chr2:26,592,429-28,607,344

Best TWAS P=5.96e-28 · Best GWAS P=3.82e-28 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GTF3C2 0.06 0.09 lasso 8 0.08 7.2e-10 -6.91 8.2 3.6e-16 0.72 0.34 0.66 FALSE
2 CommonMind Brain Pre-frontal Cortex IFT172 0.06 0.09 enet 16 0.09 3.9e-11 -6.76 -8.6 5.9e-18 -0.75 0.44 0.56 FALSE
3 CommonMind Brain Pre-frontal Cortex PPM1G 0.03 0.01 bslmm 305 0.00 8.7e-02 -7.36 -6.3 2.8e-10 -0.50 0.60 0.06 FALSE
4 GTEx Adipose Subcutaneous NRBP1 0.07 0.04 lasso 5 0.05 6.9e-05 -6.75 6.0 1.7e-09 0.53 0.75 0.20 FALSE
5 GTEx Adipose Subcutaneous PPM1G 0.04 0.05 lasso 2 0.04 4.9e-04 -6.87 6.6 3.1e-11 0.59 0.59 0.04 FALSE
6 GTEx Adipose Subcutaneous AC074117.10 0.06 0.04 lasso 5 0.02 4.8e-03 -7.22 7.4 1.0e-13 0.65 0.48 0.22 FALSE
7 GTEx Adipose Visceral Omentum NRBP1 0.05 0.05 lasso 4 0.04 2.5e-03 -6.87 7.2 8.4e-13 0.61 0.34 0.06 FALSE
8 GTEx Adipose Visceral Omentum PPM1G 0.06 0.01 lasso 5 0.01 1.1e-01 -6.87 7.3 2.2e-13 0.64 0.11 0.28 FALSE
9 GTEx Adipose Visceral Omentum KRTCAP3 0.10 0.07 lasso 4 0.06 5.2e-04 -6.91 -6.9 4.8e-12 -0.61 0.68 0.10 FALSE
10 GTEx Adipose Visceral Omentum AC074117.10 0.14 0.09 lasso 3 0.08 5.0e-05 -7.36 7.3 3.0e-13 0.60 0.86 0.07 FALSE
11 GTEx Adrenal Gland KRTCAP3 0.11 0.16 lasso 4 0.15 4.9e-06 -7.33 -7.2 7.7e-13 -0.60 0.49 0.45 FALSE
12 GTEx Artery Aorta NRBP1 0.06 0.07 enet 8 0.06 2.6e-04 -6.86 5.3 1.1e-07 0.51 0.50 0.04 FALSE
13 GTEx Artery Aorta AC074117.10 0.06 0.04 lasso 3 0.03 6.8e-03 -7.36 7.3 2.3e-13 0.58 0.25 0.11 FALSE
14 GTEx Artery Coronary NRBP1 0.09 0.01 enet 14 0.03 4.4e-02 -3.52 5.3 8.9e-08 0.46 0.18 0.27 FALSE
15 GTEx Artery Coronary AC074117.10 0.13 0.17 enet 9 0.12 5.4e-05 -4.05 5.7 1.0e-08 0.47 0.12 0.69 FALSE
16 GTEx Artery Tibial NRBP1 0.07 0.03 lasso 11 0.05 1.3e-04 -6.84 5.7 1.0e-08 0.50 0.56 0.16 FALSE
17 GTEx Artery Tibial PPM1G 0.06 0.02 lasso 4 0.03 2.3e-03 -6.88 7.5 4.3e-14 0.66 0.28 0.13 FALSE
18 GTEx Artery Tibial AC074117.10 0.13 0.14 lasso 5 0.13 1.1e-10 -7.36 7.5 8.1e-14 0.62 1.00 0.00 FALSE
19 GTEx Brain Cerebellum AC074117.10 0.13 0.08 enet 6 0.07 4.4e-03 -7.46 -7.5 9.2e-14 -0.60 0.10 0.42 FALSE
20 GTEx Brain Cortex KRTCAP3 0.19 0.10 lasso 2 0.12 3.7e-04 -5.90 -6.2 4.3e-10 -0.54 0.26 0.31 FALSE
21 GTEx Brain Nucleus accumbens basal ganglia OST4 0.23 0.06 lasso 4 0.08 3.1e-03 -4.70 -5.6 2.2e-08 -0.34 0.06 0.12 FALSE
22 GTEx Breast Mammary Tissue (Female) ABHD1 0.17 0.01 enet 28 0.07 5.3e-03 -0.87 -5.2 1.8e-07 -0.52 0.02 0.73 FALSE
23 GTEx Cells EBV-transformed lymphocytes NRBP1 0.11 0.13 enet 13 0.15 1.2e-05 -7.33 7.4 1.1e-13 0.62 0.57 0.10 FALSE
24 GTEx Cells Transformed fibroblasts NRBP1 0.09 0.08 lasso 3 0.08 7.8e-07 -7.36 7.3 2.6e-13 0.61 0.96 0.04 FALSE
25 GTEx Cells Transformed fibroblasts IFT172 0.04 0.04 lasso 2 0.02 8.1e-03 -6.95 -7.1 1.4e-12 -0.60 0.19 0.31 FALSE
26 GTEx Cells Transformed fibroblasts AC074117.10 0.21 0.19 enet 23 0.18 1.6e-13 -7.22 7.0 3.6e-12 0.66 0.90 0.10 FALSE
27 GTEx Colon Sigmoid AC074117.10 0.13 0.18 lasso 3 0.14 1.1e-05 -7.36 7.3 2.5e-13 0.60 0.87 0.07 FALSE
28 GTEx Colon Transverse NRBP1 0.08 0.03 enet 14 0.00 2.0e-01 -6.86 6.5 1.0e-10 0.59 0.17 0.12 FALSE
29 GTEx Colon Transverse AC074117.10 0.13 0.13 enet 16 0.14 2.3e-07 -6.91 6.0 1.4e-09 0.51 0.95 0.03 FALSE
30 GTEx Esophagus Gastroesophageal Junction AC074117.10 0.12 0.13 enet 9 0.09 4.9e-04 -7.43 7.7 1.3e-14 0.64 0.45 0.26 FALSE
31 GTEx Esophagus Mucosa NRBP1 0.13 0.06 enet 13 0.06 4.1e-05 -7.22 5.2 2.0e-07 0.50 0.71 0.20 FALSE
32 GTEx Esophagus Mucosa AC074117.10 0.12 0.14 lasso 8 0.14 2.1e-09 -7.22 8.6 5.9e-18 0.74 0.93 0.07 FALSE
33 GTEx Esophagus Muscularis NRBP1 0.07 0.04 lasso 6 0.04 1.3e-03 -7.22 8.8 1.0e-18 0.82 0.02 0.96 FALSE
34 GTEx Esophagus Muscularis PPM1G 0.06 0.10 lasso 2 0.07 3.7e-05 -7.48 7.1 9.3e-13 0.57 0.36 0.54 FALSE
35 GTEx Esophagus Muscularis AC074117.10 0.17 0.14 enet 5 0.09 6.6e-06 -7.22 7.5 6.7e-14 0.65 0.78 0.21 FALSE
36 GTEx Lung NRBP1 0.05 0.05 enet 9 0.05 1.7e-04 -6.88 6.9 4.3e-12 0.61 0.75 0.15 FALSE
37 GTEx Lung AC074117.10 0.07 0.06 lasso 6 0.05 6.6e-05 -6.88 7.1 1.2e-12 0.63 0.77 0.22 FALSE
38 GTEx Muscle Skeletal SNX17 0.18 0.24 lasso 6 0.26 6.2e-26 -6.82 7.1 9.2e-13 0.61 1.00 0.00 FALSE
39 GTEx Muscle Skeletal KRTCAP3 0.08 0.06 lasso 4 0.04 3.1e-05 -7.48 -7.4 1.1e-13 -0.59 1.00 0.00 FALSE
40 GTEx Muscle Skeletal GPN1 0.06 0.02 enet 9 0.02 2.9e-03 3.24 6.0 1.6e-09 0.43 0.28 0.10 FALSE
41 GTEx Nerve Tibial NRBP1 0.06 0.00 enet 9 0.02 2.0e-02 -7.22 6.9 4.7e-12 0.61 0.33 0.54 FALSE
42 GTEx Nerve Tibial PPM1G 0.09 0.06 lasso 4 0.05 1.2e-04 -7.01 6.7 2.1e-11 0.57 0.45 0.35 FALSE
43 GTEx Nerve Tibial AC074117.10 0.04 0.05 lasso 2 0.04 7.7e-04 -6.53 5.9 3.9e-09 0.50 0.18 0.44 FALSE
44 GTEx Ovary AC074117.10 0.16 0.04 enet 9 0.05 2.0e-02 -6.87 8.6 7.3e-18 0.77 0.04 0.77 FALSE
45 GTEx Pituitary AC074117.10 0.23 0.23 lasso 8 0.29 5.6e-08 -7.01 7.5 4.5e-14 0.66 0.39 0.51 FALSE
46 GTEx Prostate AC074117.10 0.14 0.01 lasso 5 0.02 8.8e-02 -7.22 6.6 5.5e-11 0.61 0.07 0.56 FALSE
47 GTEx Skin Not Sun Exposed Suprapubic NRBP1 0.19 0.15 lasso 7 0.16 6.0e-09 -6.88 6.4 1.5e-10 0.58 1.00 0.00 FALSE
48 GTEx Skin Sun Exposed Lower leg NRBP1 0.10 0.08 lasso 6 0.08 3.6e-07 -7.43 6.8 7.9e-12 0.58 1.00 0.00 FALSE
49 GTEx Skin Sun Exposed Lower leg SLC4A1AP 0.04 0.01 lasso 3 0.02 1.7e-02 -7.36 -7.7 1.0e-14 -0.60 0.21 0.11 FALSE
50 GTEx Testis NRBP1 0.16 0.09 lasso 3 0.06 1.8e-03 -7.22 8.8 1.3e-18 0.80 0.03 0.96 FALSE
51 GTEx Testis AC074117.10 0.14 0.08 lasso 6 0.12 4.5e-06 -7.47 10.0 1.1e-23 0.85 0.04 0.96 FALSE
52 GTEx Testis RP11-195B17.1 0.13 0.00 lasso 4 0.02 4.5e-02 -6.88 7.1 1.4e-12 0.58 0.04 0.14 FALSE
53 GTEx Thyroid FNDC4 0.24 0.10 enet 23 0.16 2.2e-12 -4.19 -7.9 2.2e-15 -0.69 0.64 0.36 FALSE
54 GTEx Thyroid PPM1G 0.06 0.06 lasso 3 0.06 2.2e-05 -6.87 7.0 1.9e-12 0.60 0.92 0.01 FALSE
55 GTEx Thyroid AC074117.10 0.17 0.14 lasso 4 0.15 2.7e-11 -7.43 7.4 1.6e-13 0.61 1.00 0.00 FALSE
56 GTEx Vagina AC074117.10 0.14 0.04 enet 13 0.06 1.4e-02 -5.90 7.8 4.8e-15 0.72 0.09 0.52 FALSE
57 GTEx Whole Blood KRTCAP3 0.12 0.05 enet 10 0.05 9.9e-06 -6.75 -7.1 9.4e-13 -0.63 0.97 0.01 FALSE
58 METSIM Adipose KRTCAP3 0.05 0.01 blup 288 0.03 1.6e-05 -6.75 -6.6 4.7e-11 -0.52 0.96 0.03 FALSE
59 METSIM Adipose NRBP1 0.06 0.09 lasso 3 0.08 1.6e-12 -7.22 7.5 7.8e-14 0.67 1.00 0.00 FALSE
60 METSIM Adipose SLC5A6 0.03 0.02 bslmm 298 0.01 3.9e-03 -3.64 5.2 2.5e-07 0.43 0.25 0.06 FALSE
61 NTR Blood CGREF1 0.01 0.00 blup 307 0.01 5.7e-03 -2.49 -5.8 6.9e-09 -0.49 0.20 0.08 FALSE
62 ROSMAP Brain Pre-frontal Cortex SNX17 0.27 0.35 lasso 10 0.34 7.9e-46 -6.84 -6.9 4.6e-12 -0.60 1.00 0.00 FALSE
63 ROSMAP Brain Pre-frontal Cortex IFT172 0.07 0.02 blup 287 0.03 5.8e-05 -7.36 -6.6 4.9e-11 -0.63 0.43 0.49 FALSE
64 ROSMAP Brain Pre-frontal Cortex KRTCAP3 0.06 0.05 blup 279 0.05 3.1e-07 -6.87 -7.0 2.9e-12 -0.58 1.00 0.00 FALSE
65 ROSMAP Brain Pre-frontal Cortex ZNF513 0.04 0.05 blup 280 0.05 1.3e-06 -7.33 5.6 2.4e-08 0.47 1.00 0.00 FALSE
66 ROSMAP Brain Pre-frontal Cortex FTH1P3 0.04 0.01 bslmm 280 0.02 2.8e-03 -7.22 6.8 1.1e-11 0.65 0.04 0.71 FALSE
67 YFS Blood EIF2B4 0.01 0.00 enet 9 0.00 8.5e-02 -3.99 -5.5 3.2e-08 -0.52 0.04 0.04 FALSE
68 YFS Blood KRTCAP3 0.12 0.18 bslmm 286 0.18 1.0e-55 -6.81 -7.0 1.8e-12 -0.59 1.00 0.00 FALSE
69 YFS Blood NRBP1 0.01 0.01 lasso 6 0.01 9.1e-06 -7.47 7.2 5.5e-13 0.61 0.99 0.00 FALSE
70 YFS Blood SNX17 0.05 0.03 blup 288 0.04 1.0e-11 -7.36 6.0 1.7e-09 0.48 1.00 0.00 FALSE
71 The Cancer Genome Atlas Bladder Urothelial Carcinoma NRBP1 0.05 0.06 lasso 2 0.05 6.0e-05 -6.80 6.8 1.0e-11 0.60 0.80 0.04 FALSE
72 The Cancer Genome Atlas Bladder Urothelial Carcinoma PPM1G 0.03 0.02 blup 31 0.02 8.8e-03 -7.46 7.7 1.3e-14 0.66 0.03 0.51 FALSE
73 The Cancer Genome Atlas Breast Invasive Carcinoma GPN1 0.06 0.02 lasso 6 0.02 7.2e-05 6.65 6.2 5.3e-10 0.54 0.00 0.97 FALSE
74 The Cancer Genome Atlas Breast Invasive Carcinoma KRTCAP3 0.01 0.00 blup 27 0.00 8.7e-02 -5.90 -6.1 1.0e-09 -0.56 0.05 0.02 FALSE
75 The Cancer Genome Atlas Breast Invasive Carcinoma NRBP1 0.03 0.03 blup 29 0.03 1.2e-06 -6.53 6.5 7.9e-11 0.57 0.97 0.02 FALSE
76 The Cancer Genome Atlas Breast Invasive Carcinoma SNX17 0.08 0.01 blup 25 0.02 6.6e-05 -1.21 -5.1 3.1e-07 -0.55 0.02 0.34 FALSE
77 The Cancer Genome Atlas Colon Adenocarcinoma NRBP1 0.03 0.04 lasso 1 0.03 5.2e-03 -7.36 7.4 1.8e-13 0.59 0.04 0.11 FALSE
78 The Cancer Genome Atlas Glioblastoma Multiforme NRBP1 0.15 0.10 lasso 2 0.10 5.8e-04 -7.22 7.3 3.8e-13 0.67 0.02 0.09 FALSE
79 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IFT172 0.02 0.01 blup 43 0.02 2.7e-03 -6.53 7.0 3.5e-12 0.60 0.10 0.12 FALSE
80 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma KRTCAP3 0.02 0.01 blup 28 0.01 2.9e-02 -6.81 -6.7 1.9e-11 -0.57 0.08 0.05 FALSE
81 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NRBP1 0.06 0.07 lasso 2 0.07 1.1e-08 -6.75 6.8 1.4e-11 0.60 0.99 0.01 FALSE
82 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SNX17 0.02 0.01 blup 26 0.01 2.1e-02 -6.81 -7.2 7.8e-13 -0.62 0.13 0.19 FALSE
83 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FNDC4 0.13 0.06 lasso 2 0.05 1.1e-03 11.00 -11.0 6.0e-28 -0.99 0.00 0.95 TRUE
84 The Cancer Genome Atlas Brain Lower Grade Glioma PPM1G 0.03 0.03 blup 32 0.02 9.3e-04 -6.81 6.8 1.5e-11 0.56 0.36 0.06 FALSE
85 The Cancer Genome Atlas Lung Adenocarcinoma NRBP1 0.03 0.05 blup 30 0.05 3.7e-06 -6.75 6.8 1.2e-11 0.59 0.95 0.03 FALSE
86 The Cancer Genome Atlas Prostate Adenocarcinoma NRBP1 0.03 0.03 blup 30 0.03 2.2e-04 -5.90 7.4 1.1e-13 0.64 0.66 0.10 FALSE
87 The Cancer Genome Atlas Prostate Adenocarcinoma PPM1G 0.03 0.02 blup 32 0.02 2.4e-03 -6.95 7.0 1.8e-12 0.61 0.16 0.06 FALSE
88 The Cancer Genome Atlas Thyroid Carcinoma FNDC4 0.24 0.09 enet 9 0.17 1.9e-16 -5.05 -8.2 2.3e-16 -0.70 0.43 0.57 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma GCKR 0.18 0.08 enet 5 0.13 1.7e-12 -4.19 -7.5 6.6e-14 -0.64 0.89 0.11 FALSE
90 The Cancer Genome Atlas Thyroid Carcinoma IFT172 0.08 0.01 blup 43 0.02 6.1e-03 -5.05 -6.7 2.8e-11 -0.54 0.02 0.29 FALSE
91 The Cancer Genome Atlas Thyroid Carcinoma KRTCAP3 0.04 0.04 lasso 1 0.03 3.4e-04 -5.90 -5.9 3.6e-09 -0.55 0.11 0.11 FALSE
92 The Cancer Genome Atlas Thyroid Carcinoma NRBP1 0.03 0.01 blup 30 0.02 5.3e-03 -7.22 7.1 1.3e-12 0.62 0.32 0.06 FALSE