[Hub]/) : Traits : Gout (self-reported) : →

chr2:26,592,429-28,607,344

Best TWAS P=5.96e-28 · Best GWAS P=3.82e-28 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	-6.91	8.2	3.6e-16	0.72	0.34	0.66	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	-6.76	-8.6	5.9e-18	-0.75	0.44	0.56	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PPM1G	0.03	0.01	bslmm	305	0.00	8.7e-02	-7.36	-6.3	2.8e-10	-0.50	0.60	0.06	FALSE
4	GTEx	Adipose Subcutaneous	NRBP1	0.07	0.04	lasso	5	0.05	6.9e-05	-6.75	6.0	1.7e-09	0.53	0.75	0.20	FALSE
5	GTEx	Adipose Subcutaneous	PPM1G	0.04	0.05	lasso	2	0.04	4.9e-04	-6.87	6.6	3.1e-11	0.59	0.59	0.04	FALSE
6	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	-7.22	7.4	1.0e-13	0.65	0.48	0.22	FALSE
7	GTEx	Adipose Visceral Omentum	NRBP1	0.05	0.05	lasso	4	0.04	2.5e-03	-6.87	7.2	8.4e-13	0.61	0.34	0.06	FALSE
8	GTEx	Adipose Visceral Omentum	PPM1G	0.06	0.01	lasso	5	0.01	1.1e-01	-6.87	7.3	2.2e-13	0.64	0.11	0.28	FALSE
9	GTEx	Adipose Visceral Omentum	KRTCAP3	0.10	0.07	lasso	4	0.06	5.2e-04	-6.91	-6.9	4.8e-12	-0.61	0.68	0.10	FALSE
10	GTEx	Adipose Visceral Omentum	AC074117.10	0.14	0.09	lasso	3	0.08	5.0e-05	-7.36	7.3	3.0e-13	0.60	0.86	0.07	FALSE
11	GTEx	Adrenal Gland	KRTCAP3	0.11	0.16	lasso	4	0.15	4.9e-06	-7.33	-7.2	7.7e-13	-0.60	0.49	0.45	FALSE
12	GTEx	Artery Aorta	NRBP1	0.06	0.07	enet	8	0.06	2.6e-04	-6.86	5.3	1.1e-07	0.51	0.50	0.04	FALSE
13	GTEx	Artery Aorta	AC074117.10	0.06	0.04	lasso	3	0.03	6.8e-03	-7.36	7.3	2.3e-13	0.58	0.25	0.11	FALSE
14	GTEx	Artery Coronary	NRBP1	0.09	0.01	enet	14	0.03	4.4e-02	-3.52	5.3	8.9e-08	0.46	0.18	0.27	FALSE
15	GTEx	Artery Coronary	AC074117.10	0.13	0.17	enet	9	0.12	5.4e-05	-4.05	5.7	1.0e-08	0.47	0.12	0.69	FALSE
16	GTEx	Artery Tibial	NRBP1	0.07	0.03	lasso	11	0.05	1.3e-04	-6.84	5.7	1.0e-08	0.50	0.56	0.16	FALSE
17	GTEx	Artery Tibial	PPM1G	0.06	0.02	lasso	4	0.03	2.3e-03	-6.88	7.5	4.3e-14	0.66	0.28	0.13	FALSE
18	GTEx	Artery Tibial	AC074117.10	0.13	0.14	lasso	5	0.13	1.1e-10	-7.36	7.5	8.1e-14	0.62	1.00	0.00	FALSE
19	GTEx	Brain Cerebellum	AC074117.10	0.13	0.08	enet	6	0.07	4.4e-03	-7.46	-7.5	9.2e-14	-0.60	0.10	0.42	FALSE
20	GTEx	Brain Cortex	KRTCAP3	0.19	0.10	lasso	2	0.12	3.7e-04	-5.90	-6.2	4.3e-10	-0.54	0.26	0.31	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	OST4	0.23	0.06	lasso	4	0.08	3.1e-03	-4.70	-5.6	2.2e-08	-0.34	0.06	0.12	FALSE
22	GTEx	Breast Mammary Tissue (Female)	ABHD1	0.17	0.01	enet	28	0.07	5.3e-03	-0.87	-5.2	1.8e-07	-0.52	0.02	0.73	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	NRBP1	0.11	0.13	enet	13	0.15	1.2e-05	-7.33	7.4	1.1e-13	0.62	0.57	0.10	FALSE
24	GTEx	Cells Transformed fibroblasts	NRBP1	0.09	0.08	lasso	3	0.08	7.8e-07	-7.36	7.3	2.6e-13	0.61	0.96	0.04	FALSE
25	GTEx	Cells Transformed fibroblasts	IFT172	0.04	0.04	lasso	2	0.02	8.1e-03	-6.95	-7.1	1.4e-12	-0.60	0.19	0.31	FALSE
26	GTEx	Cells Transformed fibroblasts	AC074117.10	0.21	0.19	enet	23	0.18	1.6e-13	-7.22	7.0	3.6e-12	0.66	0.90	0.10	FALSE
27	GTEx	Colon Sigmoid	AC074117.10	0.13	0.18	lasso	3	0.14	1.1e-05	-7.36	7.3	2.5e-13	0.60	0.87	0.07	FALSE
28	GTEx	Colon Transverse	NRBP1	0.08	0.03	enet	14	0.00	2.0e-01	-6.86	6.5	1.0e-10	0.59	0.17	0.12	FALSE
29	GTEx	Colon Transverse	AC074117.10	0.13	0.13	enet	16	0.14	2.3e-07	-6.91	6.0	1.4e-09	0.51	0.95	0.03	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	-7.43	7.7	1.3e-14	0.64	0.45	0.26	FALSE
31	GTEx	Esophagus Mucosa	NRBP1	0.13	0.06	enet	13	0.06	4.1e-05	-7.22	5.2	2.0e-07	0.50	0.71	0.20	FALSE
32	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	-7.22	8.6	5.9e-18	0.74	0.93	0.07	FALSE
33	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	-7.22	8.8	1.0e-18	0.82	0.02	0.96	FALSE
34	GTEx	Esophagus Muscularis	PPM1G	0.06	0.10	lasso	2	0.07	3.7e-05	-7.48	7.1	9.3e-13	0.57	0.36	0.54	FALSE
35	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	-7.22	7.5	6.7e-14	0.65	0.78	0.21	FALSE
36	GTEx	Lung	NRBP1	0.05	0.05	enet	9	0.05	1.7e-04	-6.88	6.9	4.3e-12	0.61	0.75	0.15	FALSE
37	GTEx	Lung	AC074117.10	0.07	0.06	lasso	6	0.05	6.6e-05	-6.88	7.1	1.2e-12	0.63	0.77	0.22	FALSE
38	GTEx	Muscle Skeletal	SNX17	0.18	0.24	lasso	6	0.26	6.2e-26	-6.82	7.1	9.2e-13	0.61	1.00	0.00	FALSE
39	GTEx	Muscle Skeletal	KRTCAP3	0.08	0.06	lasso	4	0.04	3.1e-05	-7.48	-7.4	1.1e-13	-0.59	1.00	0.00	FALSE
40	GTEx	Muscle Skeletal	GPN1	0.06	0.02	enet	9	0.02	2.9e-03	3.24	6.0	1.6e-09	0.43	0.28	0.10	FALSE
41	GTEx	Nerve Tibial	NRBP1	0.06	0.00	enet	9	0.02	2.0e-02	-7.22	6.9	4.7e-12	0.61	0.33	0.54	FALSE
42	GTEx	Nerve Tibial	PPM1G	0.09	0.06	lasso	4	0.05	1.2e-04	-7.01	6.7	2.1e-11	0.57	0.45	0.35	FALSE
43	GTEx	Nerve Tibial	AC074117.10	0.04	0.05	lasso	2	0.04	7.7e-04	-6.53	5.9	3.9e-09	0.50	0.18	0.44	FALSE
44	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	-6.87	8.6	7.3e-18	0.77	0.04	0.77	FALSE
45	GTEx	Pituitary	AC074117.10	0.23	0.23	lasso	8	0.29	5.6e-08	-7.01	7.5	4.5e-14	0.66	0.39	0.51	FALSE
46	GTEx	Prostate	AC074117.10	0.14	0.01	lasso	5	0.02	8.8e-02	-7.22	6.6	5.5e-11	0.61	0.07	0.56	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	NRBP1	0.19	0.15	lasso	7	0.16	6.0e-09	-6.88	6.4	1.5e-10	0.58	1.00	0.00	FALSE
48	GTEx	Skin Sun Exposed Lower leg	NRBP1	0.10	0.08	lasso	6	0.08	3.6e-07	-7.43	6.8	7.9e-12	0.58	1.00	0.00	FALSE
49	GTEx	Skin Sun Exposed Lower leg	SLC4A1AP	0.04	0.01	lasso	3	0.02	1.7e-02	-7.36	-7.7	1.0e-14	-0.60	0.21	0.11	FALSE
50	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	-7.22	8.8	1.3e-18	0.80	0.03	0.96	FALSE
51	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	-7.47	10.0	1.1e-23	0.85	0.04	0.96	FALSE
52	GTEx	Testis	RP11-195B17.1	0.13	0.00	lasso	4	0.02	4.5e-02	-6.88	7.1	1.4e-12	0.58	0.04	0.14	FALSE
53	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	-4.19	-7.9	2.2e-15	-0.69	0.64	0.36	FALSE
54	GTEx	Thyroid	PPM1G	0.06	0.06	lasso	3	0.06	2.2e-05	-6.87	7.0	1.9e-12	0.60	0.92	0.01	FALSE
55	GTEx	Thyroid	AC074117.10	0.17	0.14	lasso	4	0.15	2.7e-11	-7.43	7.4	1.6e-13	0.61	1.00	0.00	FALSE
56	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	-5.90	7.8	4.8e-15	0.72	0.09	0.52	FALSE
57	GTEx	Whole Blood	KRTCAP3	0.12	0.05	enet	10	0.05	9.9e-06	-6.75	-7.1	9.4e-13	-0.63	0.97	0.01	FALSE
58	METSIM	Adipose	KRTCAP3	0.05	0.01	blup	288	0.03	1.6e-05	-6.75	-6.6	4.7e-11	-0.52	0.96	0.03	FALSE
59	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	-7.22	7.5	7.8e-14	0.67	1.00	0.00	FALSE
60	METSIM	Adipose	SLC5A6	0.03	0.02	bslmm	298	0.01	3.9e-03	-3.64	5.2	2.5e-07	0.43	0.25	0.06	FALSE
61	NTR	Blood	CGREF1	0.01	0.00	blup	307	0.01	5.7e-03	-2.49	-5.8	6.9e-09	-0.49	0.20	0.08	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	SNX17	0.27	0.35	lasso	10	0.34	7.9e-46	-6.84	-6.9	4.6e-12	-0.60	1.00	0.00	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	-7.36	-6.6	4.9e-11	-0.63	0.43	0.49	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	KRTCAP3	0.06	0.05	blup	279	0.05	3.1e-07	-6.87	-7.0	2.9e-12	-0.58	1.00	0.00	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	ZNF513	0.04	0.05	blup	280	0.05	1.3e-06	-7.33	5.6	2.4e-08	0.47	1.00	0.00	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	FTH1P3	0.04	0.01	bslmm	280	0.02	2.8e-03	-7.22	6.8	1.1e-11	0.65	0.04	0.71	FALSE
67	YFS	Blood	EIF2B4	0.01	0.00	enet	9	0.00	8.5e-02	-3.99	-5.5	3.2e-08	-0.52	0.04	0.04	FALSE
68	YFS	Blood	KRTCAP3	0.12	0.18	bslmm	286	0.18	1.0e-55	-6.81	-7.0	1.8e-12	-0.59	1.00	0.00	FALSE
69	YFS	Blood	NRBP1	0.01	0.01	lasso	6	0.01	9.1e-06	-7.47	7.2	5.5e-13	0.61	0.99	0.00	FALSE
70	YFS	Blood	SNX17	0.05	0.03	blup	288	0.04	1.0e-11	-7.36	6.0	1.7e-09	0.48	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBP1	0.05	0.06	lasso	2	0.05	6.0e-05	-6.80	6.8	1.0e-11	0.60	0.80	0.04	FALSE
72	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPM1G	0.03	0.02	blup	31	0.02	8.8e-03	-7.46	7.7	1.3e-14	0.66	0.03	0.51	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	6.65	6.2	5.3e-10	0.54	0.00	0.97	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	KRTCAP3	0.01	0.00	blup	27	0.00	8.7e-02	-5.90	-6.1	1.0e-09	-0.56	0.05	0.02	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBP1	0.03	0.03	blup	29	0.03	1.2e-06	-6.53	6.5	7.9e-11	0.57	0.97	0.02	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX17	0.08	0.01	blup	25	0.02	6.6e-05	-1.21	-5.1	3.1e-07	-0.55	0.02	0.34	FALSE
77	The Cancer Genome Atlas	Colon Adenocarcinoma	NRBP1	0.03	0.04	lasso	1	0.03	5.2e-03	-7.36	7.4	1.8e-13	0.59	0.04	0.11	FALSE
78	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	-7.22	7.3	3.8e-13	0.67	0.02	0.09	FALSE
79	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IFT172	0.02	0.01	blup	43	0.02	2.7e-03	-6.53	7.0	3.5e-12	0.60	0.10	0.12	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KRTCAP3	0.02	0.01	blup	28	0.01	2.9e-02	-6.81	-6.7	1.9e-11	-0.57	0.08	0.05	FALSE
81	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBP1	0.06	0.07	lasso	2	0.07	1.1e-08	-6.75	6.8	1.4e-11	0.60	0.99	0.01	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX17	0.02	0.01	blup	26	0.01	2.1e-02	-6.81	-7.2	7.8e-13	-0.62	0.13	0.19	FALSE
83	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	11.00	-11.0	6.0e-28	-0.99	0.00	0.95	TRUE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPM1G	0.03	0.03	blup	32	0.02	9.3e-04	-6.81	6.8	1.5e-11	0.56	0.36	0.06	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBP1	0.03	0.05	blup	30	0.05	3.7e-06	-6.75	6.8	1.2e-11	0.59	0.95	0.03	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBP1	0.03	0.03	blup	30	0.03	2.2e-04	-5.90	7.4	1.1e-13	0.64	0.66	0.10	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPM1G	0.03	0.02	blup	32	0.02	2.4e-03	-6.95	7.0	1.8e-12	0.61	0.16	0.06	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	-5.05	-8.2	2.3e-16	-0.70	0.43	0.57	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	-4.19	-7.5	6.6e-14	-0.64	0.89	0.11	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	-5.05	-6.7	2.8e-11	-0.54	0.02	0.29	FALSE
91	The Cancer Genome Atlas	Thyroid Carcinoma	KRTCAP3	0.04	0.04	lasso	1	0.03	3.4e-04	-5.90	-5.9	3.6e-09	-0.55	0.11	0.11	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	NRBP1	0.03	0.01	blup	30	0.02	5.3e-03	-7.22	7.1	1.3e-12	0.62	0.32	0.06	FALSE