[Hub]/) : Traits : High cholesterol (Self-reported) :

chr2:26,624,843-28,607,344

Best TWAS P=3.34e-36 · Best GWAS P=3.17e-36 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GTF3C2 0.06 0.09 lasso 8 0.08 7.2e-10 -5.8 7.8 7.3e-15 0.72 0.28 0.72 FALSE
2 CommonMind Brain Pre-frontal Cortex IFT172 0.06 0.09 enet 16 0.09 3.9e-11 -6.0 -8.2 2.7e-16 -0.75 0.48 0.52 FALSE
3 GTEx Adipose Subcutaneous NRBP1 0.07 0.04 lasso 5 0.05 6.9e-05 -6.1 5.3 1.3e-07 0.53 0.72 0.23 FALSE
4 GTEx Adipose Subcutaneous PPM1G 0.04 0.05 lasso 2 0.04 4.9e-04 -6.0 6.0 2.3e-09 0.59 0.59 0.04 FALSE
5 GTEx Adipose Subcutaneous AC074117.10 0.06 0.04 lasso 5 0.02 4.8e-03 -7.7 7.6 2.2e-14 0.65 0.45 0.27 FALSE
6 GTEx Adipose Visceral Omentum NRBP1 0.05 0.05 lasso 4 0.04 2.5e-03 -6.0 6.0 1.5e-09 0.61 0.34 0.07 FALSE
7 GTEx Adipose Visceral Omentum PPM1G 0.06 0.01 lasso 5 0.01 1.1e-01 -6.0 6.7 1.8e-11 0.64 0.11 0.28 FALSE
8 GTEx Adipose Visceral Omentum KRTCAP3 0.10 0.07 lasso 4 0.06 5.2e-04 -5.8 -5.8 5.5e-09 -0.61 0.68 0.10 FALSE
9 GTEx Adipose Visceral Omentum AC074117.10 0.14 0.09 lasso 3 0.08 5.0e-05 -6.1 6.1 1.2e-09 0.60 0.85 0.08 FALSE
10 GTEx Adrenal Gland KRTCAP3 0.11 0.16 lasso 4 0.15 4.9e-06 -6.2 -6.2 7.4e-10 -0.60 0.54 0.38 FALSE
11 GTEx Artery Aorta AC074117.10 0.06 0.04 lasso 3 0.03 6.8e-03 -6.1 6.0 1.8e-09 0.58 0.24 0.14 FALSE
12 GTEx Artery Tibial NRBP1 0.07 0.03 lasso 11 0.05 1.3e-04 -5.9 5.1 3.1e-07 0.50 0.54 0.19 FALSE
13 GTEx Artery Tibial PPM1G 0.06 0.02 lasso 4 0.03 2.3e-03 -5.8 7.3 3.1e-13 0.66 0.29 0.12 FALSE
14 GTEx Artery Tibial AC074117.10 0.13 0.14 lasso 5 0.13 1.1e-10 -6.1 6.7 2.1e-11 0.62 0.99 0.00 FALSE
15 GTEx Brain Cerebellum AC074117.10 0.13 0.08 enet 6 0.07 4.4e-03 -5.9 -6.1 8.7e-10 -0.60 0.09 0.48 FALSE
16 GTEx Brain Cortex KRTCAP3 0.19 0.10 lasso 2 0.12 3.7e-04 -5.9 -5.9 3.7e-09 -0.54 0.24 0.35 FALSE
17 GTEx Breast Mammary Tissue (Female) ABHD1 0.17 0.01 enet 28 0.07 5.3e-03 0.3 -6.7 2.0e-11 -0.52 0.02 0.76 FALSE
18 GTEx Cells EBV-transformed lymphocytes NRBP1 0.11 0.13 enet 13 0.15 1.2e-05 -6.2 6.7 2.9e-11 0.62 0.57 0.10 FALSE
19 GTEx Cells Transformed fibroblasts NRBP1 0.09 0.08 lasso 3 0.08 7.8e-07 -6.1 5.7 1.0e-08 0.61 0.95 0.04 FALSE
20 GTEx Cells Transformed fibroblasts IFT172 0.04 0.04 lasso 2 0.02 8.1e-03 -5.9 -6.0 1.9e-09 -0.60 0.20 0.25 FALSE
21 GTEx Cells Transformed fibroblasts AC074117.10 0.21 0.19 enet 23 0.18 1.6e-13 -7.7 7.7 9.8e-15 0.66 0.87 0.13 FALSE
22 GTEx Colon Sigmoid AC074117.10 0.13 0.18 lasso 3 0.14 1.1e-05 -6.1 6.1 1.2e-09 0.60 0.85 0.08 FALSE
23 GTEx Colon Transverse NRBP1 0.08 0.03 enet 14 0.00 2.0e-01 -6.8 6.1 1.3e-09 0.59 0.16 0.14 FALSE
24 GTEx Colon Transverse AC074117.10 0.13 0.13 enet 16 0.14 2.3e-07 -5.8 5.3 1.4e-07 0.51 0.94 0.04 FALSE
25 GTEx Esophagus Gastroesophageal Junction NRBP1 0.11 0.01 enet 23 0.02 7.7e-02 -4.3 6.2 6.9e-10 0.53 0.12 0.24 FALSE
26 GTEx Esophagus Gastroesophageal Junction AC074117.10 0.12 0.13 enet 9 0.09 4.9e-04 -6.0 6.0 1.7e-09 0.64 0.43 0.30 FALSE
27 GTEx Esophagus Mucosa NRBP1 0.13 0.06 enet 13 0.06 4.1e-05 -7.7 5.4 7.5e-08 0.50 0.68 0.23 FALSE
28 GTEx Esophagus Mucosa AC074117.10 0.12 0.14 lasso 8 0.14 2.1e-09 -7.7 8.5 2.0e-17 0.74 0.94 0.06 FALSE
29 GTEx Esophagus Muscularis NRBP1 0.07 0.04 lasso 6 0.04 1.3e-03 -7.7 9.9 6.1e-23 0.82 0.01 0.97 FALSE
30 GTEx Esophagus Muscularis PPM1G 0.06 0.10 lasso 2 0.07 3.7e-05 -6.2 6.2 6.7e-10 0.57 0.34 0.57 FALSE
31 GTEx Esophagus Muscularis AC074117.10 0.17 0.14 enet 5 0.09 6.6e-06 -7.7 7.4 1.2e-13 0.65 0.73 0.26 FALSE
32 GTEx Lung NRBP1 0.05 0.05 enet 9 0.05 1.7e-04 -5.8 6.0 2.1e-09 0.61 0.75 0.16 FALSE
33 GTEx Lung AC074117.10 0.07 0.06 lasso 6 0.05 6.6e-05 -5.8 6.2 7.6e-10 0.63 0.75 0.25 FALSE
34 GTEx Muscle Skeletal SNX17 0.18 0.24 lasso 6 0.26 6.2e-26 -5.9 6.0 2.1e-09 0.61 1.00 0.00 FALSE
35 GTEx Muscle Skeletal KRTCAP3 0.08 0.06 lasso 4 0.04 3.1e-05 -6.2 -6.1 1.1e-09 -0.59 1.00 0.00 FALSE
36 GTEx Muscle Skeletal GPN1 0.06 0.02 enet 9 0.02 2.9e-03 4.1 7.0 3.7e-12 0.43 0.29 0.07 FALSE
37 GTEx Nerve Tibial NRBP1 0.06 0.00 enet 9 0.02 2.0e-02 -7.7 6.2 5.7e-10 0.61 0.28 0.61 FALSE
38 GTEx Nerve Tibial PPM1G 0.09 0.06 lasso 4 0.05 1.2e-04 -6.1 6.0 2.0e-09 0.57 0.41 0.40 FALSE
39 GTEx Nerve Tibial AC074117.10 0.04 0.05 lasso 2 0.04 7.7e-04 -6.0 5.8 5.1e-09 0.50 0.16 0.50 FALSE
40 GTEx Ovary AC074117.10 0.16 0.04 enet 9 0.05 2.0e-02 -6.0 8.8 2.0e-18 0.77 0.04 0.80 FALSE
41 GTEx Pituitary AC074117.10 0.23 0.23 lasso 8 0.29 5.6e-08 -6.1 7.1 9.8e-13 0.66 0.34 0.57 FALSE
42 GTEx Prostate AC074117.10 0.14 0.01 lasso 5 0.02 8.8e-02 -7.7 6.9 5.7e-12 0.61 0.06 0.59 FALSE
43 GTEx Skin Not Sun Exposed Suprapubic NRBP1 0.19 0.15 lasso 7 0.16 6.0e-09 -5.8 5.5 3.3e-08 0.58 1.00 0.00 FALSE
44 GTEx Skin Sun Exposed Lower leg NRBP1 0.10 0.08 lasso 6 0.08 3.6e-07 -6.0 6.4 1.8e-10 0.58 1.00 0.00 FALSE
45 GTEx Skin Sun Exposed Lower leg SLC4A1AP 0.04 0.01 lasso 3 0.02 1.7e-02 -6.2 -6.1 1.1e-09 -0.60 0.21 0.11 FALSE
46 GTEx Stomach AC074117.10 0.06 0.01 lasso 7 0.01 7.8e-02 -7.7 -5.8 7.1e-09 -0.36 0.20 0.08 FALSE
47 GTEx Testis NRBP1 0.16 0.09 lasso 3 0.06 1.8e-03 -7.7 9.6 1.3e-21 0.80 0.03 0.96 FALSE
48 GTEx Testis AC074117.10 0.14 0.08 lasso 6 0.12 4.5e-06 -6.1 9.7 3.5e-22 0.85 0.05 0.94 FALSE
49 GTEx Thyroid FNDC4 0.24 0.10 enet 23 0.16 2.2e-12 -5.1 -8.7 3.1e-18 -0.69 0.67 0.33 FALSE
50 GTEx Thyroid PPM1G 0.06 0.06 lasso 3 0.06 2.2e-05 -6.0 6.1 9.4e-10 0.60 0.92 0.01 FALSE
51 GTEx Thyroid AC074117.10 0.17 0.14 lasso 4 0.15 2.7e-11 -6.0 6.1 1.1e-09 0.61 1.00 0.00 FALSE
52 GTEx Vagina AC074117.10 0.14 0.04 enet 13 0.06 1.4e-02 -5.9 8.2 3.0e-16 0.72 0.08 0.57 FALSE
53 GTEx Whole Blood KRTCAP3 0.12 0.05 enet 10 0.05 9.9e-06 -6.1 -6.3 2.6e-10 -0.63 0.97 0.01 FALSE
54 METSIM Adipose ATRAID 0.11 0.09 bslmm 297 0.10 1.4e-14 -3.5 -5.2 2.2e-07 -0.47 1.00 0.00 FALSE
55 METSIM Adipose KRTCAP3 0.05 0.01 blup 288 0.03 1.6e-05 -6.1 -5.6 1.7e-08 -0.52 0.96 0.03 FALSE
56 METSIM Adipose NRBP1 0.06 0.09 lasso 3 0.08 1.6e-12 -7.7 7.8 4.6e-15 0.67 1.00 0.00 FALSE
57 METSIM Adipose SLC5A6 0.03 0.02 bslmm 298 0.01 3.9e-03 -4.2 6.0 2.0e-09 0.43 0.25 0.04 FALSE
58 NTR Blood CGREF1 0.01 0.00 blup 307 0.01 5.7e-03 -3.0 -6.5 8.0e-11 -0.49 0.20 0.07 FALSE
59 ROSMAP Brain Pre-frontal Cortex SNX17 0.27 0.35 lasso 10 0.34 7.9e-46 -5.9 -6.0 2.3e-09 -0.60 1.00 0.00 FALSE
60 ROSMAP Brain Pre-frontal Cortex IFT172 0.07 0.02 blup 287 0.03 5.8e-05 -6.1 -6.8 9.2e-12 -0.63 0.43 0.49 FALSE
61 ROSMAP Brain Pre-frontal Cortex KRTCAP3 0.06 0.05 blup 279 0.05 3.1e-07 -6.0 -5.2 2.1e-07 -0.58 0.99 0.00 FALSE
62 ROSMAP Brain Pre-frontal Cortex FTH1P3 0.04 0.01 bslmm 280 0.02 2.8e-03 -7.7 8.4 4.3e-17 0.65 0.04 0.70 FALSE
63 YFS Blood EIF2B4 0.01 0.00 enet 9 0.00 8.5e-02 -3.5 -6.3 3.7e-10 -0.52 0.04 0.03 FALSE
64 YFS Blood KRTCAP3 0.12 0.18 bslmm 286 0.18 1.0e-55 -6.1 -5.6 1.8e-08 -0.59 1.00 0.00 FALSE
65 YFS Blood NRBP1 0.01 0.01 lasso 6 0.01 9.1e-06 -6.1 6.8 8.4e-12 0.61 0.99 0.00 FALSE
66 The Cancer Genome Atlas Bladder Urothelial Carcinoma NRBP1 0.05 0.06 lasso 2 0.05 6.0e-05 -5.9 5.9 3.5e-09 0.60 0.82 0.01 FALSE
67 The Cancer Genome Atlas Bladder Urothelial Carcinoma PPM1G 0.03 0.02 blup 31 0.02 8.8e-03 -5.9 7.0 3.0e-12 0.66 0.03 0.51 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma EIF2B4 0.08 0.01 lasso 2 0.01 1.0e-02 -3.7 -5.2 2.1e-07 -0.35 0.03 0.02 FALSE
69 The Cancer Genome Atlas Breast Invasive Carcinoma GPN1 0.06 0.02 lasso 6 0.02 7.2e-05 9.6 8.5 1.9e-17 0.54 0.01 0.97 FALSE
70 The Cancer Genome Atlas Breast Invasive Carcinoma KRTCAP3 0.01 0.00 blup 27 0.00 8.7e-02 -5.9 -5.4 5.6e-08 -0.56 0.05 0.02 FALSE
71 The Cancer Genome Atlas Breast Invasive Carcinoma NRBP1 0.03 0.03 blup 29 0.03 1.2e-06 -6.0 5.7 1.5e-08 0.57 0.99 0.00 FALSE
72 The Cancer Genome Atlas Breast Invasive Carcinoma SNX17 0.08 0.01 blup 25 0.02 6.6e-05 -3.7 -7.3 2.1e-13 -0.55 0.02 0.34 FALSE
73 The Cancer Genome Atlas Colon Adenocarcinoma NRBP1 0.03 0.04 lasso 1 0.03 5.2e-03 -6.2 6.2 5.8e-10 0.59 0.04 0.11 FALSE
74 The Cancer Genome Atlas Esophageal Carcinoma C2orf28 0.30 0.04 enet 26 0.11 3.0e-04 -4.3 -5.2 2.5e-07 -0.31 0.01 0.43 FALSE
75 The Cancer Genome Atlas Glioblastoma Multiforme NRBP1 0.15 0.10 lasso 2 0.10 5.8e-04 -7.7 7.7 1.0e-14 0.67 0.02 0.09 FALSE
76 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IFT172 0.02 0.01 blup 43 0.02 2.7e-03 -6.0 6.0 1.8e-09 0.60 0.10 0.10 FALSE
77 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC4A1AP 0.02 0.03 lasso 2 0.03 3.7e-04 4.0 -7.0 3.0e-12 -0.47 0.01 0.83 FALSE
78 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma KRTCAP3 0.02 0.01 blup 28 0.01 2.9e-02 -6.1 -5.8 4.9e-09 -0.57 0.08 0.05 FALSE
79 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NRBP1 0.06 0.07 lasso 2 0.07 1.1e-08 -6.1 6.1 1.2e-09 0.60 1.00 0.00 FALSE
80 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SNX17 0.02 0.01 blup 26 0.01 2.1e-02 -5.9 -6.2 4.2e-10 -0.62 0.13 0.18 FALSE
81 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SUPT7L 0.05 0.02 blup 28 0.04 5.2e-05 -5.3 -7.1 1.7e-12 -0.40 0.19 0.14 FALSE
82 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CCDC121 0.09 0.03 enet 8 0.02 1.9e-02 4.0 5.5 4.5e-08 0.36 0.03 0.60 FALSE
83 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FNDC4 0.13 0.06 lasso 2 0.05 1.1e-03 12.6 -12.6 3.3e-36 -0.99 0.00 0.96 TRUE
84 The Cancer Genome Atlas Brain Lower Grade Glioma PPM1G 0.03 0.03 blup 32 0.02 9.3e-04 -5.9 5.5 3.7e-08 0.56 0.36 0.05 FALSE
85 The Cancer Genome Atlas Lung Adenocarcinoma NRBP1 0.03 0.05 blup 30 0.05 3.7e-06 -6.1 5.8 5.0e-09 0.59 0.97 0.01 FALSE
86 The Cancer Genome Atlas Prostate Adenocarcinoma NRBP1 0.03 0.03 blup 30 0.03 2.2e-04 -5.9 6.8 9.8e-12 0.64 0.67 0.08 FALSE
87 The Cancer Genome Atlas Prostate Adenocarcinoma PPM1G 0.03 0.02 blup 32 0.02 2.4e-03 -5.9 6.1 9.2e-10 0.61 0.16 0.05 FALSE
88 The Cancer Genome Atlas Skin Cutaneous Melanoma SLC4A1AP 0.17 0.05 blup 26 0.08 4.4e-03 9.6 -6.9 6.5e-12 -0.47 0.01 0.72 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma FNDC4 0.24 0.09 enet 9 0.17 1.9e-16 -5.3 -9.3 1.3e-20 -0.70 0.41 0.59 FALSE
90 The Cancer Genome Atlas Thyroid Carcinoma GCKR 0.18 0.08 enet 5 0.13 1.7e-12 -5.1 -8.5 1.4e-17 -0.64 0.91 0.09 FALSE
91 The Cancer Genome Atlas Thyroid Carcinoma IFT172 0.08 0.01 blup 43 0.02 6.1e-03 -6.0 -7.0 3.7e-12 -0.54 0.02 0.27 FALSE
92 The Cancer Genome Atlas Thyroid Carcinoma KRTCAP3 0.04 0.04 lasso 1 0.03 3.4e-04 -5.9 -5.9 3.0e-09 -0.55 0.11 0.11 FALSE
93 The Cancer Genome Atlas Thyroid Carcinoma NRBP1 0.03 0.01 blup 30 0.02 5.3e-03 -7.7 6.6 4.7e-11 0.62 0.32 0.05 FALSE