Best TWAS P=6.74e-23 · Best GWAS P=2.59e-34 conditioned to 0.00338
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TMEM176A | 0.07 | 0.04 | lasso | 8 | 0.03 | 7.0e-05 | 6.2 | 6.3 | 3.9e-10 | -0.18 | 0.68 | 0.03 | FALSE |
| 2 | GTEx | Artery Coronary | RP11-148K1.12 | 0.31 | -0.01 | enet | 16 | 0.00 | 2.2e-01 | 5.8 | -6.9 | 4.3e-12 | 0.17 | 0.08 | 0.06 | TRUE |
| 3 | GTEx | Brain Cerebellar Hemisphere | KCNH2 | 0.34 | 0.09 | lasso | 5 | 0.12 | 5.0e-04 | 5.1 | -6.9 | 6.4e-12 | 0.67 | 0.02 | 0.83 | FALSE |
| 4 | GTEx | Brain Cerebellum | KCNH2 | 0.35 | 0.20 | enet | 24 | 0.28 | 4.8e-09 | -11.5 | -9.8 | 6.7e-23 | 0.83 | 0.00 | 1.00 | TRUE |
| 5 | GTEx | Colon Transverse | ABCB8 | 0.17 | 0.12 | lasso | 2 | 0.07 | 4.8e-04 | 5.8 | 5.7 | 1.1e-08 | -0.10 | 0.36 | 0.03 | TRUE |
| 6 | GTEx | Esophagus Mucosa | SLC4A2 | 0.11 | 0.03 | enet | 8 | 0.06 | 5.1e-05 | 6.2 | 6.3 | 2.7e-10 | -0.23 | 0.86 | 0.02 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | TMEM176B | 0.37 | 0.06 | enet | 15 | 0.23 | 1.1e-10 | -1.2 | -6.1 | 1.4e-09 | 0.34 | 0.55 | 0.10 | FALSE |
| 8 | GTEx | Heart Left Ventricle | TMEM176B | 0.19 | 0.09 | enet | 10 | 0.14 | 3.9e-08 | -5.4 | -5.2 | 2.3e-07 | 0.38 | 0.98 | 0.00 | FALSE |
| 9 | GTEx | Muscle Skeletal | AGAP3 | 0.10 | 0.04 | lasso | 5 | 0.03 | 8.5e-04 | 5.8 | -5.4 | 8.1e-08 | 0.13 | 0.66 | 0.04 | FALSE |
| 10 | GTEx | Thyroid | SMARCD3 | 0.10 | 0.01 | lasso | 3 | 0.01 | 3.5e-02 | 5.4 | 5.2 | 2.2e-07 | -0.13 | 0.23 | 0.03 | FALSE |
| 11 | GTEx | Uterus | GIMAP4 | 0.32 | -0.01 | enet | 42 | 0.02 | 1.4e-01 | -1.1 | -8.0 | 8.9e-16 | 0.48 | 0.05 | 0.20 | FALSE |
| 12 | GTEx | Whole Blood | AGAP3 | 0.09 | 0.04 | lasso | 4 | 0.03 | 1.3e-03 | 5.4 | -5.4 | 7.3e-08 | 0.14 | 0.84 | 0.00 | FALSE |
| 13 | METSIM | Adipose | AOC1 | 0.17 | 0.08 | enet | 26 | 0.11 | 3.2e-16 | 5.6 | 6.6 | 3.4e-11 | -0.30 | 1.00 | 0.00 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | TMEM176A | 0.25 | 0.17 | enet | 19 | 0.20 | 1.5e-25 | 3.8 | 6.3 | 3.9e-10 | -0.09 | 1.00 | 0.00 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | TMUB1 | 0.05 | 0.01 | bslmm | 511 | 0.01 | 7.2e-03 | 5.5 | -5.5 | 3.2e-08 | 0.31 | 0.09 | 0.06 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | RP11-148K1.12 | 0.17 | 0.16 | lasso | 4 | 0.16 | 5.2e-20 | 5.5 | 5.8 | 5.9e-09 | -0.26 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TMEM176A | 0.06 | 0.01 | blup | 60 | 0.03 | 1.0e-03 | 5.8 | 6.2 | 7.6e-10 | -0.17 | 0.05 | 0.25 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ABP1 | 0.16 | 0.19 | lasso | 4 | 0.20 | 9.3e-22 | -6.6 | 6.1 | 8.7e-10 | -0.25 | 1.00 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM176A | 0.19 | 0.05 | lasso | 6 | 0.13 | 2.6e-14 | -6.6 | 6.9 | 5.1e-12 | -0.11 | 0.06 | 0.94 | FALSE |
| 20 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABP1 | 0.26 | 0.20 | enet | 10 | 0.17 | 1.4e-08 | -6.5 | -7.9 | 3.1e-15 | 0.39 | 0.86 | 0.13 | FALSE |
| 21 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ATG9B | 0.08 | 0.03 | lasso | 3 | 0.03 | 2.5e-03 | 1.5 | -5.3 | 9.4e-08 | 0.49 | 0.02 | 0.69 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM176A | 0.15 | 0.01 | blup | 60 | 0.04 | 6.1e-05 | 8.8 | 5.8 | 6.4e-09 | -0.17 | 0.07 | 0.66 | FALSE |
| 23 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMEM176A | 0.15 | 0.00 | lasso | 10 | 0.02 | 5.7e-02 | 8.8 | 7.2 | 7.0e-13 | -0.24 | 0.01 | 0.31 | TRUE |