TWAS hub - OBFC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1210	0.0320	3.3e-06	0.038	0.049	0.032	0.050	0.050	1.6e-05	1.2e-06	8.4e-05	9.9e-07	8.4e-07
2	GTEx	Cells Transformed fibroblasts	0.1420	0.0460	3.3e-04	0.071	NA	0.039	NA	0.056	5.2e-06	NA	6.6e-04	NA	5.0e-05
3	GTEx	Esophagus Mucosa	0.1500	0.0540	6.0e-04	-0.004	NA	0.006	NA	-0.004	8.4e-01	NA	1.1e-01	NA	8.8e-01
4	GTEx	Esophagus Muscularis	0.0980	0.0450	9.5e-03	-0.003	NA	-0.004	NA	-0.004	5.8e-01	NA	6.5e-01	NA	6.6e-01
5	GTEx	Muscle Skeletal	0.0800	0.0316	4.5e-03	0.024	NA	0.040	NA	0.032	1.8e-03	NA	7.8e-05	NA	3.8e-04
6	GTEx	Thyroid	0.0940	0.0360	2.2e-03	-0.001	NA	0.006	NA	0.005	3.7e-01	NA	1.1e-01	NA	1.3e-01
7	METSIM	Adipose	0.0595	0.0229	2.5e-04	0.053	0.032	0.036	0.035	0.043	2.3e-08	1.4e-05	3.3e-06	4.7e-06	3.7e-07
8	NTR	Blood	0.0256	0.0117	1.1e-02	0.000	0.002	-0.001	0.003	-0.001	5.3e-01	6.4e-02	7.2e-01	3.9e-02	9.1e-01
9	YFS	Blood	0.1059	0.0221	0.0e+00	0.051	0.073	0.075	0.069	0.076	2.9e-16	1.2e-22	2.7e-23	1.2e-21	8.3e-24
10	TCGA	Brain Lower Grade Glioma	0.0422	0.0205	3.5e-04	0.041	0.029	0.033	NA	0.031	1.7e-05	2.9e-04	1.1e-04	NA	1.6e-04
11	TCGA	Lung Squamous Cell Carcinoma	0.0317	0.0175	2.4e-03	0.015	0.012	0.010	NA	0.014	6.5e-03	1.3e-02	2.5e-02	NA	8.1e-03
12	TCGA	Pheochromocytoma and Paraganglioma	0.1120	0.0590	5.0e-03	0.058	0.074	0.059	NA	0.069	2.5e-03	7.1e-04	2.3e-03	NA	1.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Ever had hysterectomy (womb removed)	9.4	10.6	23.1	-4.0	-3.3	-2.8	-3.6	2.2	-2.8	-0.4	-1.4	-0.6	-4.8	-4.8	-4.3
Bilateral oophorectomy (both ovaries removed)	6.3	7.3	21.6	-4.2	-3.5	-1.4	-1.9	1.1	-1.4	-0.6	-0.3	-1.5	-3.5	-4.7	-3.6
Systolic Blood Pressure	5.7	28.4	58.4	-7.5	-6.7	-2.6	-5.3	5.3	-4.0	-0.2	-3.6	-2.3	-6.6	-7.6	-6.3
Mouth/teeth dental problems	5.2	8.0	17.6	2.0	2.1	4.1	4.1	-3.6	1.3	1.4	2.2	1.3	4.2	2.6	2.5
Medication: Amlodipine	4.9	6.9	13.8	-3.7	-3.7	-2.0	-3.0	2.5	-0.8	-0.8	-1.8	-1.9	-3.1	-3.4	-2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.9	10.3	27.2	5.2	5.0	1.8	1.4	-4.3	-1.8	-0.8	2.1	2.6	1.7	3.6	4.2
Illnesses of father: High blood pressure	4.5	5.5	12.7	-3.3	-2.3	-0.6	-1.7	1.2	-1.1	-1.9	-1.6	-2.1	-3.0	-3.6	-3.5
Coronary Artery Disease (CAD)	4.3	5.2	10.5	2.9	3.2	2.6	1.2	-2.9	0.8	0.1	1.2	1.0	2.6	3.1	2.8
Systolic blood pressure, automated reading	4.0	11.6	30.7	-5.5	-5.3	-0.9	-2.3	3.6	-0.8	0.8	-2.5	-2.1	-2.9	-4.8	-4.1
Medication: Bendroflumethiazide	3.8	5.8	11.3	-3.3	-3.4	-1.7	-2.5	2.7	-1.4	1.5	-1.7	-0.2	-3.0	-2.8	-2.6
Medication: Blood pressure	3.7	6.5	14.2	-3.8	-3.5	-2.3	-2.3	0.8	0.2	-0.9	-1.2	-1.8	-3.1	-3.6	-3.5
Average weekly champagne plus white wine intake	3.5	4.8	15.4	3.5	2.7	0.4	0.7	-1.4	1.4	0.3	1.6	1.7	1.5	3.9	3.2
Medication: Lisinopril	3.5	4.6	8.4	-2.6	-2.9	-2.6	-2.6	2.3	-1.3	-0.1	-2.1	-1.5	-2.3	-1.9	-1.9
Angina (self-reported)	3.4	4.4	13.5	3.7	3.0	0.4	0.4	-3.2	-0.4	-1.5	1.0	0.8	0.5	3.2	2.4
Blood Red Count	3.3	31.7	71.7	-8.5	-7.4	-3.5	-3.9	6.1	-0.6	-1.1	-3.9	-3.8	-6.6	-8.2	-6.9
High blood pressure	3.3	9.3	19.3	-4.3	-3.9	-2.6	-3.4	1.6	-0.6	1.0	-1.2	-0.7	-3.7	-4.4	-4.4
Heart disease (siblings)	3.3	4.1	11.2	3.2	3.4	0.2	0.4	-3.2	1.2	-0.2	2.1	1.7	1.4	1.8	1.7
High blood pressure (siblings)	3.2	4.6	12.1	-3.5	-3.2	-0.9	-2.1	1.7	-0.7	-0.9	0.9	-1.6	-2.3	-2.8	-2.7
Lung FVC	3.1	15.6	36.0	5.8	6.0	3.7	2.4	-5.6	-0.8	-0.0	3.1	3.3	2.9	4.2	4.5
Hypertension (Self-reported)	3.1	8.6	19.0	-4.2	-3.8	-2.4	-3.3	1.3	-0.6	0.4	-1.3	-1.1	-3.6	-4.2	-4.4
Angina	3.0	4.0	12.1	3.5	2.9	0.1	0.2	-2.9	-0.1	-1.6	0.9	0.7	0.4	3.0	2.3
High blood pressure (mother)	3.0	4.3	8.1	-2.8	-2.8	-0.5	-2.4	2.4	-1.4	0.4	-1.1	-0.9	-2.8	-2.6	-2.3
Medication for cholesterol	3.0	4.5	8.6	2.6	2.2	2.8	2.2	-1.7	2.0	0.3	1.0	1.1	2.0	2.9	2.9
Cardiovascular Disease	2.9	9.5	18.5	-3.8	-3.5	-2.7	-4.1	1.5	-1.9	-0.4	-1.6	-1.2	-4.3	-4.1	-4.2
Pulse wave reflection index	2.8	3.5	9.3	-2.3	-3.1	-2.4	-1.7	1.9	0.5	-1.4	-1.7	-2.8	-0.4	-1.0	-0.8
Leg pain on walking	2.8	3.5	9.3	3.0	2.8	0.7	1.9	-1.6	0.8	-0.6	0.7	0.4	1.4	2.5	2.8
Heart disease (mother)	2.7	3.3	9.6	3.1	2.6	-0.0	0.0	-1.9	0.5	-0.1	0.9	0.9	2.1	2.8	2.4
Ovarian Cancer	2.6	3.4	9.1	1.9	1.0	1.4	1.1	-1.4	1.9	0.7	2.5	0.7	1.9	3.0	2.8
Unable to work because of sickness or disability	2.6	3.3	11.4	-0.8	-0.8	-2.2	-2.6	0.3	-0.8	-0.1	-2.5	0.6	-3.4	-2.1	-1.9
Supplements: Calcium	2.6	2.9	7.1	2.0	2.7	1.7	2.3	-1.3	-0.1	-0.2	1.3	1.1	2.1	1.5	1.9
Supplements: Glucosamine	2.4	3.2	6.0	2.0	1.7	2.1	2.1	0.4	1.5	1.5	-0.0	1.7	2.5	2.3	1.9
Forced expiratory volume in 1-second (FEV1)	2.4	8.2	22.2	4.3	4.7	0.1	-0.7	-2.2	-4.5	0.1	2.6	3.9	-1.2	1.5	2.5
Illnesses of father: Heart disease	2.4	3.3	10.7	2.6	2.4	0.4	-0.4	-3.3	-0.5	0.2	1.1	0.9	2.3	2.3	1.9
Ever had prostate specific antigen (PSA) test	2.4	2.8	9.7	-0.9	-1.1	-2.5	-2.7	1.0	0.7	-0.7	-1.3	-0.7	-3.1	-1.1	-1.7
Smoking status: Current	2.3	3.7	11.2	-1.7	-0.9	-0.5	-1.9	0.8	-1.1	-1.5	-1.9	-1.1	-2.3	-3.3	-3.3
Birth weight of first child	2.2	3.9	9.5	2.8	2.9	0.5	1.6	-2.1	0.3	1.5	1.7	3.1	0.8	2.0	2.1
Peak expiratory flow (PEF)	2.2	5.2	13.0	3.5	3.6	-0.8	-1.1	-0.8	-3.5	0.6	1.6	3.0	-0.2	2.1	2.4
Chronic bronchitis/emphysema (father)	2.1	2.4	13.8	-0.3	-0.1	2.3	3.7	-0.1	1.0	0.4	0.7	-0.6	2.6	0.9	0.2
Mouth/teeth dental problems: Dentures	2.1	3.6	14.0	-1.3	-1.4	-2.4	-3.7	2.2	-1.3	-0.5	-0.9	-0.5	-3.0	-1.3	-1.0
Alzheimer’s Disease (including proxy)	2.0	2.8	7.3	0.3	-0.4	0.1	1.4	1.0	2.7	-0.9	2.4	-1.4	2.7	2.2	1.7
Heart attack	2.0	2.5	6.3	2.5	2.2	0.6	1.4	-1.3	-1.3	-0.9	0.7	0.1	1.2	2.3	2.3
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.6	13.6	1.4	1.3	1.7	1.5	-0.7	-3.7	-0.1	1.8	0.7	1.2	1.1	1.1
Medication: Gliclazide	2.0	2.3	9.7	1.9	2.5	0.3	0.0	-2.0	-1.1	1.4	0.8	3.1	-0.2	0.2	-0.1
Number of operations (self-reported)	2.0	2.9	8.6	-1.6	-1.7	-1.7	-2.0	2.5	-1.4	0.1	-0.9	-0.5	-2.9	-1.8	-1.4
Stomach or abdominal pain in last month	1.9	2.3	5.5	-2.3	-2.0	-0.5	0.9	1.7	-0.1	1.1	-1.6	0.2	-1.1	-2.4	-1.9
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	6.8	-1.0	-1.0	-2.5	-1.9	1.9	-1.2	-0.7	-0.7	-0.2	-2.6	-1.6	-1.4
Vascular/heart problems diagnosed by doctor	1.9	5.1	11.4	2.6	2.5	2.4	3.4	-0.6	0.5	0.0	1.0	0.7	3.2	2.9	3.2
Current tobacco smoking	1.8	3.0	9.0	-1.1	-0.3	-0.5	-2.1	0.5	-1.0	-1.1	-2.2	-0.5	-2.3	-3.0	-3.0
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	6.5	-1.7	-1.8	2.1	2.5	-0.2	2.2	0.5	-0.6	-1.2	0.9	-0.3	-0.1
Schizophrenia vs Biploar Disorder	1.7	2.2	8.0	1.6	1.5	2.8	0.4	-1.2	-1.8	1.3	1.2	2.2	0.2	0.8	0.5
Blood Platelet Count	1.7	20.2	51.3	-3.5	-1.6	-4.7	-4.5	2.8	-6.7	-2.5	-1.4	-1.1	-7.2	-6.0	-6.0
Lung FEV1/FVC ratio	1.7	8.7	20.3	3.9	4.3	-1.2	-4.3	-2.1	-4.5	0.9	0.8	4.2	-2.6	0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	14.9	3.6	3.8	-0.3	-0.3	-1.5	-3.9	-0.5	1.9	2.9	-1.2	1.0	2.2
Headache pain in last month	1.7	2.9	6.6	-2.6	-2.3	-0.5	0.9	2.1	-1.8	-0.9	-1.2	-1.7	-0.6	-2.3	-1.6
Medication: Ibuprofen	1.7	2.1	6.4	1.4	1.0	1.4	1.7	-1.0	-2.5	-0.6	1.7	0.1	1.5	1.5	1.6
Alcohol drinker status: Never	1.7	2.0	6.0	2.0	1.9	0.1	0.3	-1.6	-0.8	-0.7	2.5	1.0	0.7	1.7	1.5
Diastolic blood pressure, automated reading	1.7	5.3	11.8	-2.8	-2.4	-2.3	-2.1	2.4	-2.5	-0.3	-1.6	-1.2	-2.6	-3.4	-2.5
Serious illness, injury or assault to yourself	1.6	2.0	10.3	2.0	1.7	0.4	-0.2	-0.6	-3.2	-0.3	0.2	0.7	-1.3	1.2	1.5
Had menopause	1.6	2.0	5.2	0.6	1.0	2.1	1.7	-1.8	0.6	1.2	1.8	1.0	2.3	0.8	0.9
Forced vital capacity (FVC)	1.6	6.3	19.4	3.9	4.4	0.2	0.1	-2.2	-3.4	-0.3	2.4	3.3	-1.3	1.2	2.0
Medication: Ventolin 100micrograms inhaler	1.6	2.1	7.2	-1.7	-1.5	-0.5	0.4	1.5	0.2	-1.3	-2.7	-1.7	0.0	-1.3	-1.9
Medication: Seretide 50 evohaler	1.6	1.8	8.0	-0.8	0.2	-0.3	-1.5	-1.2	-0.0	0.1	-1.1	0.7	-1.5	-2.2	-2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	8.5	-1.6	-1.9	-1.6	-1.5	2.9	1.0	0.6	-0.5	-0.4	-0.3	-0.6	-0.7
Schizophrenia (2018)	1.5	3.1	8.2	2.0	1.7	2.7	1.8	-1.0	1.5	0.5	0.2	0.5	2.9	2.2	1.7
Respiratory disease	1.5	3.4	7.8	-2.7	-2.8	-0.3	0.8	1.9	2.0	-1.4	-1.8	-2.8	-0.6	-1.5	-1.5
Hearing difficulty/problems: Yes	1.5	2.2	8.1	1.5	1.7	2.3	0.8	-0.8	-1.0	0.1	2.8	1.3	0.1	1.2	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	6.6	-0.9	-1.2	-2.2	-2.1	1.8	-0.2	-0.7	-2.6	-1.3	-1.5	-1.0	-0.9
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	8.8	-1.8	-1.6	-0.4	0.3	2.1	0.8	3.0	-0.1	1.2	-0.6	-1.2	-0.7
Asthma	1.5	3.0	8.6	-2.5	-2.2	0.1	0.7	1.2	1.4	-0.4	-2.9	-1.5	-0.3	-1.9	-2.4
Impedance of arm (left)	1.5	6.8	30.7	-0.6	-0.7	-3.0	-3.7	2.5	-5.5	0.1	-0.9	0.7	-4.0	-1.5	-0.7
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	6.5	2.1	1.8	1.4	1.5	0.6	-0.7	0.5	0.4	0.9	1.9	2.2	2.5
Migraine (self-reported)	1.5	1.9	7.2	0.9	0.5	-0.8	1.4	-0.7	1.4	-0.5	1.5	-0.5	2.7	1.8	1.9
Heart attack/myocardial infarction (self-reported)	1.5	2.0	4.9	2.2	2.0	0.5	1.3	-1.2	-1.3	-1.1	0.5	-0.2	1.0	2.0	1.8
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.2	0.1	-0.6	-1.3	-1.7	2.3	-1.5	-1.8	-2.0	-1.5	-1.4	0.4	0.1
Impedance of arm (right)	1.4	6.5	35.4	0.6	0.5	-2.7	-3.6	1.7	-6.0	0.2	-1.0	1.7	-3.8	-0.8	-0.2
Shortness of breath walking on level ground	1.4	1.7	3.1	1.7	1.5	1.5	0.9	-1.6	0.5	1.3	1.0	1.8	1.0	1.1	1.1
Medication: Allopurinol	1.4	1.9	5.1	0.5	0.0	-2.2	-2.1	0.0	-1.3	0.7	-2.2	0.8	-2.3	0.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.6	5.5	-1.8	-1.6	-0.2	0.8	-0.4	2.3	-0.3	-0.9	-1.6	1.3	-0.9	-1.3
Illness, injury, bereavement, stress in last 2 years	1.4	1.8	5.2	-2.0	-2.1	-0.8	-0.1	-0.1	2.3	1.4	-1.1	-0.3	0.1	-1.2	-1.5
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.3	1.7	1.3	1.8	0.8	-1.1	0.4	-0.0	0.3	0.3	1.7	2.1	1.7
Asthma (self-reported)	1.4	2.8	9.1	-2.2	-2.0	0.0	0.6	1.3	1.3	-0.6	-3.0	-1.5	-0.4	-1.8	-2.3
Osteoarthritis (self-reported)	1.4	1.8	6.0	1.5	1.8	2.5	0.6	-0.5	0.4	-0.9	-1.2	-0.5	2.0	1.0	1.0
Medication: Blood pressure	1.4	2.7	5.2	-2.0	-2.0	-0.9	-2.3	1.2	-1.8	1.1	-0.9	0.0	-2.0	-2.0	-2.1
Myopia	1.4	2.0	6.3	2.5	2.0	-0.1	-1.8	-1.1	0.5	-0.2	0.7	0.7	0.4	2.2	1.8
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.3	-1.7	-1.2	0.3	0.4	1.6	-1.6	1.6	-0.9	0.6	-0.2	-2.1	-1.4
Maternal smoking around birth	1.3	1.8	5.9	1.0	1.0	1.8	1.8	0.1	0.8	-0.8	0.1	-0.6	2.4	2.0	1.5
Had other major operations	1.3	1.5	3.8	-0.9	-1.2	-0.2	-0.4	1.6	-1.0	2.0	-1.3	1.5	-1.3	-1.2	-1.1
Financial difficulties in last 2 years	1.3	1.7	5.3	0.1	-0.4	-0.9	-1.5	1.6	-2.1	-2.3	-1.1	-1.7	-1.2	-0.1	0.4
Pulse wave Arterial Stiffness index	1.3	1.5	4.7	-0.7	-0.9	-0.7	-2.2	0.6	-1.4	-1.6	-0.9	-1.8	-1.0	-0.8	-0.8
Hair/balding pattern: Pattern 4	1.3	3.1	9.0	3.0	2.7	2.6	0.6	-1.0	0.7	-0.7	1.2	0.6	1.6	2.3	1.7
Forced vital capacity (FVC), Best measure	1.3	4.6	15.0	3.6	3.9	0.1	0.4	-1.7	-2.9	-1.5	1.6	1.9	-1.0	1.1	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	6.8	-0.2	0.2	-1.2	-0.6	0.0	0.0	2.6	-0.7	2.2	-1.0	-1.2	-1.1
Number of self-reported non-cancer illnesses	1.3	2.2	6.8	-1.6	-1.3	-0.8	0.1	0.5	1.1	0.9	-2.6	0.1	-1.4	-2.2	-2.4
Eye problems/disorders: Glaucoma	1.3	1.5	6.4	-0.2	-1.0	-0.2	0.8	0.3	2.5	0.1	-0.1	-1.2	1.8	1.9	1.4
Pain type(s) experienced in last month: Hip pain	1.3	1.6	5.2	1.5	1.5	1.9	0.1	-0.7	0.4	-2.3	-1.9	-0.9	0.0	0.6	0.7
Bipolar Disorder or Schizophrenia	1.2	2.9	9.9	1.5	1.2	2.2	2.2	-0.8	1.6	-0.3	-0.6	-0.8	3.1	2.1	1.8
Alzheimer’s Disease (in mother)	1.2	1.4	4.4	0.0	-0.9	-0.2	-0.3	0.7	0.9	-0.9	2.1	-0.9	1.2	1.9	1.9
Alzheimer’s Disease (in father)	1.2	1.3	6.0	0.5	0.4	-0.1	1.8	0.3	2.5	-0.3	1.3	-0.6	1.6	1.1	0.3
Verbal and Numeric Reasoning (VNR)	1.2	2.8	8.0	2.1	1.7	0.3	1.0	-1.7	2.0	0.7	0.3	1.0	1.6	2.5	2.8
Medication: Co-codamol	1.2	1.4	4.4	-0.2	0.3	1.3	0.9	-0.4	2.1	-0.6	-2.1	-0.5	-0.3	-1.4	-1.5
Nervous feelings	1.2	2.2	4.7	-1.5	-2.1	-0.0	-1.0	1.8	1.2	-0.8	-2.2	-1.9	-1.7	-1.1	-0.8
Pulse rate	1.2	2.0	7.9	2.2	2.8	1.0	-0.9	-1.7	-0.4	0.4	0.5	2.0	-0.8	0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	5.6	1.7	2.4	0.3	0.4	-1.6	-0.1	0.4	0.8	1.2	1.6	0.7	0.4
Mouth/teeth dental problems: Loose teeth	1.2	1.4	5.0	-1.3	-0.2	-0.5	0.7	0.2	0.9	1.1	-1.4	0.8	0.0	-2.0	-2.2
Neck or shoulder pain in last month	1.2	1.7	8.3	0.3	0.4	0.5	0.3	-0.5	-1.6	2.9	0.2	2.7	-0.8	-0.4	-0.4
Had major operations	1.2	1.4	3.3	-1.2	-1.0	-1.1	-1.3	1.4	-0.7	-0.8	0.1	-0.9	-1.8	-1.8	-1.0
Mineral and other dietary supplements	1.2	1.6	5.4	-0.8	-1.4	-2.1	-2.3	-0.2	0.5	-0.8	-0.4	-1.4	-1.6	-0.7	-0.7
Wears glasses or contact lenses	1.2	1.4	3.1	0.8	0.7	1.7	1.6	-1.3	1.8	-0.0	1.0	-0.0	1.7	1.2	0.5
Tinnitus: Yes, now most or all of the time	1.2	1.5	5.2	-0.2	-0.2	-2.1	-2.3	0.1	-0.3	-1.4	-0.6	-0.7	-1.9	-0.8	-0.7
Leg fat percentage (left)	1.2	4.4	17.0	0.9	1.1	3.5	3.2	-1.3	1.3	0.8	1.0	0.5	4.1	1.7	1.7
Townsend deprivation index at recruitment	1.1	1.6	5.7	-1.2	-2.0	-1.1	-1.3	0.8	-0.2	-0.4	-0.7	-1.2	-2.4	-0.6	-1.5
Body mass index (BMI)	1.1	4.8	17.8	0.5	0.6	3.6	3.5	-1.3	2.7	0.8	0.9	-0.1	4.2	1.4	1.5
Happiness	1.1	1.3	4.5	1.5	1.3	0.7	0.5	-1.2	0.4	-2.1	0.2	-1.2	1.1	1.3	1.1
Length of working week for main job	1.1	1.2	2.4	0.7	1.0	1.5	1.1	-1.1	1.2	-1.5	0.5	-0.9	1.3	0.3	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	5.6	-0.5	0.1	0.4	1.3	-0.9	-0.6	2.4	-0.2	2.1	0.7	-0.8	-0.8
Diabetes diagnosed by doctor	1.1	1.7	7.3	1.0	1.8	0.0	0.9	-1.8	0.0	2.1	-0.2	2.7	0.1	-0.3	-0.9
Breast cancer (self-reported)	1.1	1.3	4.7	0.5	1.2	-1.2	-0.6	-1.2	-0.4	0.8	-2.2	1.5	-0.4	-1.3	-1.0
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.7	-1.2	-1.8	1.1	0.1	1.9	-0.1	-0.6	-0.7	-1.6	-0.2	-1.1	-0.3
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.7	-0.4	0.5	-0.8	-0.8	-0.9	-0.9	0.7	-0.1	1.2	-1.6	-1.6	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.7	-0.2	-0.7	-1.4	-1.7	0.9	-0.7	-0.9	-2.2	-0.8	-1.6	-0.4	-0.9
Age when periods started (menarche)	1.0	2.3	12.7	-0.4	-0.1	-3.6	-1.7	0.4	-2.2	-0.7	-0.6	0.2	-1.9	-1.1	-0.8
Medication: Atenolol	1.0	1.3	4.4	1.0	0.6	-1.7	-1.8	-1.1	-0.8	0.2	0.2	1.3	-2.1	0.2	0.1
Hair/balding pattern: Pattern 2	1.0	1.3	6.3	-1.0	-1.2	-1.2	-0.7	1.2	0.6	-0.3	-2.5	-1.2	-0.3	-1.2	-0.4
Illnesses of siblings	1.0	1.3	3.8	1.3	0.9	0.8	1.8	0.1	0.1	0.6	-1.0	0.4	1.3	1.7	1.9
Standing height	1.0	9.7	31.7	1.6	2.0	-5.6	-3.4	2.4	-4.8	-1.9	-0.9	1.5	-5.5	-1.6	-0.5
Comparative body size at age 10	1.0	2.8	9.7	0.8	0.0	2.8	1.0	-0.8	3.1	0.7	0.4	-0.8	2.4	2.3	1.5
Number of children fathered	1.0	1.2	6.2	-0.2	-0.0	1.2	1.2	-0.1	1.0	0.1	1.6	-0.7	2.5	0.7	0.6
Pulse wave peak to peak time	1.0	1.1	3.8	0.7	1.1	0.1	1.8	-0.3	1.0	1.6	0.6	1.9	0.6	0.5	0.7
Alcohol intake frequency.	1.0	2.3	7.7	2.3	2.1	1.0	0.7	-2.8	-0.7	-0.9	-0.4	0.6	0.8	1.4	2.0
Family relationship satisfaction	1.0	1.3	4.7	1.3	1.0	1.1	0.8	-0.9	-0.5	-2.2	1.0	-0.7	0.4	1.0	1.5
Supplements: Vitamin C	1.0	1.2	3.5	0.9	0.5	1.9	0.4	0.5	0.1	1.4	0.3	1.3	0.9	1.4	1.6
Impedance of whole body	1.0	5.0	27.3	0.1	0.0	-2.6	-3.3	1.4	-5.2	-0.1	-1.0	1.0	-3.3	-0.7	-0.2
Rheumatoid Arthritis	0.9	1.3	5.1	1.5	0.9	-2.3	-1.2	-0.4	-1.1	-0.4	0.6	0.4	-0.3	1.5	1.2
Hand grip strength (left)	0.9	2.3	12.1	-1.4	-0.4	-3.5	-0.1	1.5	-1.0	0.1	-1.8	0.1	-0.5	-1.7	-1.8
Relative age of first facial hair	0.9	1.8	6.3	0.7	0.3	-2.1	-2.1	0.7	-1.7	0.7	-0.7	1.3	-2.5	-0.3	0.1
Medication for hormone replacement therapy	0.9	1.0	3.5	-0.8	-0.5	-1.9	-0.1	1.1	-1.2	-1.3	1.0	-1.2	0.3	-0.8	-0.8
Alcohol usually taken with meals	0.9	1.5	8.9	1.2	-0.3	-0.6	-0.6	-0.0	0.4	0.7	0.8	0.3	0.4	2.4	3.0
Fluid intelligence score	0.9	1.8	4.9	1.8	1.6	-0.3	0.3	-1.6	0.8	0.7	-0.5	1.1	1.2	2.1	2.2
Glaucoma (self-reported)	0.9	1.1	3.2	-1.3	-1.8	-0.6	-0.1	0.8	1.6	-0.3	-0.3	-1.6	1.2	0.3	0.1
Gout (self-reported)	0.9	1.3	7.4	-0.1	-0.7	-2.7	-1.6	0.2	-0.4	-0.2	-1.1	-0.4	-1.7	0.4	0.4
Leg fat percentage (right)	0.9	3.1	13.4	0.1	0.4	3.3	3.0	-1.0	0.8	0.6	0.4	-0.0	3.7	0.9	1.1
Exposure to tobacco smoke outside home	0.9	1.2	2.9	1.3	1.5	1.7	1.4	-1.3	0.1	-0.4	-0.0	0.5	1.0	1.0	1.0
Commuting to job workplace: Walk	0.9	1.0	2.8	-0.8	-1.7	-0.8	-1.3	0.5	1.4	-0.6	-1.1	-1.2	-0.9	-0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.7	-1.0	-1.1	-1.5	-0.4	1.6	1.4	-0.7	-1.1	-1.1	-1.3	-1.3	-1.4
Mother’s age at death	0.9	1.1	4.4	0.6	0.4	0.7	0.9	0.7	0.1	-0.1	1.1	-0.7	2.1	1.7	1.5
Irritability	0.9	1.5	4.6	2.0	2.1	0.0	0.2	-1.0	-0.3	-0.4	0.1	0.4	1.5	1.7	1.7
Commuting to job workplace: Cycle	0.9	1.0	2.5	-1.0	-0.9	-0.5	-1.1	0.0	-1.4	0.8	-0.7	0.4	-1.3	-1.3	-1.6
Crohns Disease (2012)	0.8	1.3	3.4	-1.5	-1.5	-0.6	-1.0	1.8	-0.3	0.7	-1.5	-0.1	-1.0	-1.2	-0.8
Schizophrenia (2014)	0.8	1.7	6.7	0.9	0.6	2.3	1.8	-0.3	0.7	0.5	-0.6	-0.4	2.6	1.5	0.7
Height	0.8	15.5	44.9	2.8	3.0	-6.4	-4.1	4.0	-6.1	-1.1	-0.7	3.0	-6.7	-1.3	0.7
Allergy or Eczema	0.8	2.1	8.9	-1.8	-1.8	0.0	2.3	3.0	1.1	0.3	-0.5	-1.6	0.6	-0.4	0.1
Hypothyroidism (self reported)	0.8	1.9	7.6	1.1	1.6	2.4	1.7	-0.8	-0.5	0.8	0.5	0.9	2.8	0.4	0.2
Medication: Metformin	0.8	1.2	4.6	0.2	0.9	-0.5	0.5	-0.7	-0.2	1.8	-0.6	2.1	-0.5	-1.0	-1.8
Pack years adult smoking proportion	0.8	1.3	5.6	-1.6	-1.7	0.8	-0.2	1.0	0.3	0.2	-2.4	-0.9	-0.5	-0.9	-0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.9	0.4	-0.0	0.2	1.5	0.2	0.7	0.0	0.9	-0.2	1.7	1.4	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	7.2	0.8	0.2	1.3	1.1	1.7	1.0	0.3	0.9	-0.3	1.8	2.1	2.7
Medication: Simvastatin	0.8	1.2	3.1	-1.6	-1.3	-1.8	-0.4	0.3	0.7	-0.4	-1.4	-1.0	-0.1	-1.1	-1.6
Arm fat percentage (right)	0.8	3.1	10.7	0.7	1.0	2.9	2.8	-0.8	0.5	1.6	0.7	1.2	3.3	1.1	1.3
Birth weight	0.8	1.7	4.5	-1.7	-1.6	-1.3	0.7	1.9	-0.9	-0.3	2.1	-0.6	-1.2	-1.2	-0.7
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.2	-1.2	-1.3	0.5	1.2	0.4	1.4	1.1	-0.0	-0.3	1.5	-0.3	0.2
Eye problems/disorders: None of the above	0.8	1.0	2.4	-1.3	-0.8	-0.0	-0.2	0.1	-1.2	-1.3	0.3	-0.6	-1.3	-1.5	-1.5
Suffer from ‘nerves’	0.8	1.3	4.4	0.8	-0.0	-0.5	-2.1	1.4	0.7	-1.4	-1.0	-1.1	-1.0	0.7	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.8	5.3	1.2	1.0	-2.3	-1.4	1.5	-1.6	-0.3	-0.6	1.1	-2.0	0.3	0.8
Osteoporosis (self-reported)	0.8	1.0	2.2	0.9	1.0	1.1	0.5	-1.4	0.7	-1.2	1.5	-0.3	0.8	0.9	0.8
Financial situation satisfaction	0.8	1.0	4.2	1.5	0.7	-0.1	-2.0	-0.2	-0.7	-1.1	-0.5	-0.1	-1.3	0.8	0.9
High cholesterol (Self-reported)	0.8	1.3	3.3	-1.7	-1.8	-0.7	0.1	0.7	0.4	-0.6	-1.1	-1.3	-1.2	-1.3	-1.5
Medication: Atorvastatin	0.8	0.9	4.7	0.5	0.7	0.1	-0.5	-1.5	-0.2	-0.1	-0.5	1.1	-2.2	-1.1	-0.7
Average weekly beer plus cider intake	0.8	1.2	4.3	-1.3	-0.2	0.6	0.7	0.4	0.4	1.0	1.2	1.0	-0.6	-1.8	-2.1
Leg fat mass (left)	0.8	3.2	11.7	1.0	1.2	2.6	3.0	-1.3	1.2	0.7	0.8	0.6	3.4	1.3	1.6
Prostate Cancer	0.7	1.0	3.2	-1.3	-1.8	0.2	-0.6	0.8	0.4	-0.7	0.4	-1.4	-1.8	-0.4	-0.4
Bipolar Disorder (2011)	0.7	0.7	2.2	-0.8	-1.4	-1.5	-0.8	0.5	-0.3	0.0	-0.8	-1.2	0.1	0.6	0.2
Mean Putamen Volume	0.7	0.8	3.6	1.3	0.9	-0.1	-0.2	0.2	-0.5	-0.7	1.2	0.3	-0.5	1.0	1.9
HDL Cholesterol	0.7	1.2	3.6	0.5	0.6	0.8	1.5	-1.2	1.4	0.4	1.5	0.3	1.9	1.3	-0.1
Blood Eosinophil Count	0.7	5.0	9.8	2.8	3.1	1.5	1.5	-2.6	0.7	-0.4	3.0	1.2	2.9	2.9	1.6
Blood White Count	0.7	5.4	15.4	-1.5	-0.3	-1.4	-2.6	2.1	-3.7	0.1	-0.4	1.2	-3.9	-3.1	-3.0
BMI	0.7	4.0	14.5	-0.1	-0.0	3.8	3.2	-0.4	2.3	0.9	0.9	-0.0	3.8	0.9	1.1
Impedance of leg (right)	0.7	3.2	21.7	-0.1	0.2	-1.7	-2.1	0.6	-4.7	-0.4	-1.1	0.6	-2.4	-0.9	-0.5
Hand grip strength (right)	0.7	1.8	8.2	-1.2	-0.5	-2.9	-0.4	1.7	-1.2	-0.5	-1.8	-0.3	-0.7	-1.3	-1.2
Average weekly fortified wine intake	0.7	0.8	4.0	-0.4	-0.6	0.5	1.1	0.4	2.0	-0.3	-0.4	-1.1	1.3	0.3	0.7
Qualifications: CSEs or equivalent	0.7	0.9	2.5	-1.6	-1.2	0.7	1.1	0.4	0.4	1.5	0.5	0.7	0.0	-1.2	-0.8
Falls in the last year	0.7	1.0	3.0	1.1	0.2	-0.6	-0.8	0.1	-1.2	-1.3	0.2	-0.9	-0.9	1.2	1.7
Hair/balding pattern: Pattern 3	0.7	1.0	3.7	-0.6	0.3	0.6	0.7	-1.6	0.7	1.0	1.2	0.9	0.4	-0.5	-1.9
Medication: Lansoprazole	0.7	0.8	2.5	-0.1	0.2	0.4	0.1	0.6	0.1	1.6	-1.3	1.5	-0.2	-1.0	-1.4
Prospective memory result	0.7	0.9	4.3	-0.9	-0.4	-1.2	-0.9	-0.1	-0.3	-0.0	-0.2	-0.1	-0.6	-1.5	-2.1
Arm fat mass (right)	0.7	2.9	9.7	1.1	1.3	2.5	2.8	-0.8	1.0	0.7	0.8	0.8	3.1	1.3	1.8
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.0	0.6	1.3	2.0	1.2	-1.2	-0.3	1.0	0.4	1.2	1.9	-0.4	-0.8
Body fat percentage	0.7	2.6	9.4	0.7	0.9	2.7	2.5	-0.8	0.1	1.2	0.5	1.0	3.1	1.1	1.5
Medication for pain relief, constipation, heartburn	0.7	1.2	6.0	-1.2	-1.1	-1.2	-0.7	1.1	2.5	-0.2	0.1	-0.7	-1.2	-0.4	-0.9
Average weekly red wine intake	0.7	1.0	2.8	-1.0	-1.1	-1.7	-1.7	1.0	-0.7	1.3	-0.3	0.4	-0.8	-0.8	-0.2
Ever had bowel cancer screening	0.7	0.8	3.4	-1.3	-1.8	-0.5	-0.3	0.4	1.4	0.8	0.3	-0.5	-0.6	-0.1	-0.7
Friendships satisfaction	0.7	0.9	2.5	1.0	0.4	0.1	-0.2	-1.6	0.3	-1.4	0.7	-1.1	0.1	1.3	1.1
Fractured/broken bones in last 5 years	0.7	0.9	2.2	1.3	1.1	0.5	-0.2	-1.2	0.5	0.6	1.1	1.0	0.9	0.9	1.5
Ever depressed for a whole week	0.7	0.9	3.4	1.1	1.3	1.8	0.0	-1.3	0.2	-0.7	-0.3	-0.4	1.0	0.7	0.5
Pain experienced in last month	0.7	1.2	5.0	0.8	0.5	0.4	-0.3	-2.1	2.2	-1.1	0.6	-1.0	0.1	1.1	0.7
Intelligence (Savage-Jansen 2018)	0.6	2.0	7.1	1.2	0.5	-0.9	-0.3	-0.3	1.5	2.1	0.3	1.8	-0.1	2.0	2.7
Breast Cancer	0.6	1.5	4.3	1.2	1.0	0.7	0.5	-1.6	0.0	1.9	0.4	2.1	1.1	1.5	0.9
LDL Cholesterol	0.6	0.9	3.5	-1.9	-1.6	0.3	1.0	0.8	-0.7	0.2	-0.3	-0.9	-0.1	-1.0	-1.1
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.4	0.8	1.4	0.8	1.4	-1.0	0.2	1.5	-1.0	1.9	0.2	-0.1	-0.9
Neuroticism	0.6	1.4	4.8	1.3	0.9	2.2	0.2	-0.1	1.2	-1.5	-0.3	-0.9	0.3	1.2	1.7
Average weekly spirits intake	0.6	0.7	2.5	-0.0	0.7	1.4	0.9	-0.1	-0.0	-0.5	-1.6	-0.7	1.1	-0.6	-0.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.1	1.4	0.8	-0.8	-0.4	-0.7	-0.9	-0.3	-0.6	0.6	-1.2	1.0	1.1
Hayfever, allergic rhinitis or eczema	0.6	1.2	5.6	-1.4	-1.2	0.1	1.2	2.4	1.2	0.6	-1.1	-0.8	-0.2	-0.8	0.0
Multivitamins +/- minerals	0.6	0.8	2.9	0.4	-0.1	1.0	1.1	1.2	0.4	-0.1	0.8	-0.1	0.6	1.3	1.7
Medication: Levothyroxine sodium	0.6	1.0	3.1	1.0	1.5	1.4	1.2	-1.3	0.0	0.3	0.1	0.9	1.8	-0.1	0.0
Impedance of leg (left)	0.6	2.7	18.8	1.3	1.4	-1.2	-1.8	-0.0	-4.3	-0.2	-0.2	1.3	-1.7	0.5	0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.0	0.7	0.9	1.7	0.3	-0.7	-1.1	0.4	0.2	0.5	0.8	0.4	1.0
Allergy	0.6	1.4	3.6	1.4	1.1	-0.3	-1.4	-1.9	-1.6	0.4	1.6	1.4	-0.0	0.9	0.6
Diabetes (self-reported)	0.6	1.0	4.1	0.6	1.1	-0.2	0.6	-1.1	0.0	1.7	-0.8	2.0	-0.0	-0.5	-0.8
Hip circumference	0.6	2.6	6.4	1.5	1.8	2.1	2.3	-1.1	0.6	0.1	1.4	0.4	2.5	1.6	1.8
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.0	0.8	0.7	-1.6	-2.0	1.4	-0.6	0.9	-0.6	1.4	-1.3	0.0	0.6
Number of full brothers	0.6	0.8	2.2	-0.3	0.1	-0.7	-1.0	-0.1	-0.8	-1.5	0.1	-0.9	-1.1	-1.1	-1.2
Qualifications: College or University degree	0.6	1.8	4.2	1.2	1.1	-1.6	-1.6	0.6	-1.1	1.7	-1.1	2.0	-1.5	0.1	1.0
Emphysema/chronic bronchitis	0.6	0.7	3.3	-0.2	0.3	0.8	0.3	-0.7	0.4	-1.8	-0.3	-1.0	0.0	-0.8	-1.4
Medication: Omeprazole	0.6	0.7	3.5	-1.0	-0.8	0.6	-0.2	0.7	-1.9	-0.6	0.2	-0.6	-0.3	-1.0	-0.2
Whole body fat mass	0.6	2.3	7.4	1.1	1.3	2.2	2.5	-0.8	0.3	0.8	0.7	1.1	2.7	1.0	1.5
Leg fat mass (right)	0.6	2.5	10.0	0.6	0.8	2.4	2.9	-1.1	0.9	0.5	0.4	0.3	3.2	0.8	1.2
Pulse rate, automated reading	0.6	2.0	8.8	2.2	3.0	-0.3	-1.6	-1.3	-1.2	-1.0	-0.5	1.7	-1.0	0.0	-0.1
Age at last live birth	0.6	0.9	3.8	-1.0	-1.0	-0.5	0.4	2.0	0.8	-0.7	1.3	-1.2	-0.8	-0.5	-0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.6	2.3	-0.7	0.0	0.4	0.6	1.0	-1.5	-0.7	-1.1	-0.7	0.2	-0.9	-0.1
Arm fat percentage (left)	0.6	2.4	9.7	0.2	0.5	2.7	2.6	-0.4	0.4	1.4	0.7	0.7	3.1	0.8	1.2
Mood swings	0.6	1.0	4.5	1.0	1.0	2.1	0.9	-0.8	-0.2	-0.6	1.8	0.3	0.3	0.6	0.7
Back pain experienced in last month	0.6	0.9	4.0	-0.6	-0.4	0.5	-0.5	2.0	-1.2	1.2	-0.8	1.0	-0.6	-0.8	-0.3
Medication: Aspirin	0.6	0.7	4.8	1.1	1.3	-0.3	-0.1	-2.2	-0.4	-0.2	0.1	0.9	0.2	-0.1	-0.4
Arm fat mass (left)	0.6	2.6	8.8	1.0	1.2	2.4	2.7	-0.7	0.7	0.7	0.9	0.7	3.0	1.2	1.6
Risk taking	0.6	0.8	4.1	-0.2	-0.2	-0.6	-0.5	1.3	-2.0	-0.1	-1.2	-0.5	0.6	-0.0	1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.4	1.3	1.0	0.4	0.1	0.0	-0.9	0.1	-0.1	0.4	0.8	1.4	1.5
Pack years of smoking	0.6	0.9	4.7	-1.1	-1.4	0.9	0.0	0.6	0.7	0.4	-2.2	-0.6	0.0	-0.5	-0.3
Depression (Nagel 2018)	0.5	0.7	3.5	0.0	-0.2	-1.1	-1.0	1.2	-0.7	-0.1	-1.9	-0.1	-0.9	-0.0	-0.5
Crohns Disease (2017)	0.5	1.0	3.8	-1.9	-1.3	-0.4	-0.1	0.9	0.5	0.4	-0.3	-0.3	-0.1	-1.6	-1.5
Major Depression (MDD)	0.5	0.6	4.1	-0.0	-0.5	0.7	-0.4	0.1	-0.6	0.9	-2.0	0.7	-0.7	0.3	0.1
HbA1C	0.5	0.5	2.7	-0.5	-0.5	0.8	1.1	0.4	-0.5	0.4	1.6	0.5	0.4	-0.6	-0.2
Primary Biliary Cirrhosis	0.5	0.7	3.6	-0.9	-0.3	-0.4	-0.4	-0.5	-0.6	0.0	-1.9	-0.5	0.3	-0.8	-1.5
Triglycerides	0.5	0.9	3.7	-1.0	-1.0	0.6	0.4	1.9	-0.9	-0.6	-0.6	-0.9	-0.3	-1.1	0.5
Heel T-Score	0.5	3.7	18.0	1.0	-0.9	-0.3	-0.5	2.5	-1.3	-1.1	1.6	-1.6	-0.0	3.1	4.2
Smoking Status	0.5	1.2	4.5	-0.8	-0.4	1.3	-0.5	-0.2	0.1	-2.1	-0.1	-1.6	-0.6	-1.1	-1.7
Number of treatments/medications taken	0.5	0.9	3.2	-0.6	-0.3	0.6	0.5	-0.8	0.6	-0.0	-1.8	0.4	-0.7	-1.6	-1.7
Vitamin and mineral supplements	0.5	0.7	2.2	-0.4	-0.1	-0.8	-0.9	-1.2	-0.8	-0.3	-0.2	-0.3	-0.9	-1.3	-1.5
Fed-up feelings	0.5	0.9	2.5	-0.7	-0.5	0.8	-1.0	1.6	-0.4	-0.1	-1.2	-0.4	-1.1	-1.3	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	5.8	0.7	-0.0	0.1	0.1	1.3	0.5	-0.5	0.4	-0.8	0.8	1.9	2.4
Number of incorrect matches in round	0.5	0.9	4.1	-0.2	0.0	-2.0	-1.1	0.8	-0.7	-1.0	-0.6	-1.1	-0.3	-0.5	-0.9
Qualifications: None of the above	0.5	1.1	4.3	-1.4	-0.9	1.0	0.1	-0.6	-0.9	0.0	1.1	-0.1	-0.5	-1.7	-2.1
Medication: Ramipril	0.5	0.7	2.4	-1.6	-1.3	-0.4	0.2	0.3	1.2	0.7	-0.6	-0.5	0.4	-0.8	-0.8
Alcohol intake versus 10 years previously	0.5	0.7	3.1	-0.4	-0.5	-0.6	0.1	-0.3	-0.6	-0.3	-1.3	0.5	-1.8	-1.3	-0.5
Number of live births	0.5	0.7	4.0	-0.8	-0.9	0.3	1.0	0.9	0.3	2.0	0.7	0.3	-0.0	-0.2	-0.0
Noisy workplace	0.5	0.6	2.3	-1.0	-1.0	-0.8	0.4	0.3	1.5	0.0	0.0	-0.4	0.1	-0.9	-0.9
Blood clot in the leg (DVT)	0.5	0.7	1.9	1.3	1.0	0.5	0.2	0.1	-1.2	-0.1	-0.3	0.2	0.7	1.1	1.4
Comparative height size at age 10	0.5	2.9	8.4	0.9	0.9	-2.4	-2.3	1.8	-2.0	-2.4	0.6	-0.0	-2.9	-0.7	-0.4
Number of full sisters	0.5	0.7	2.3	1.0	0.2	0.0	-0.0	-0.8	0.6	0.9	0.9	0.7	0.8	1.5	0.9
Long-standing illness, disability or infirmity	0.5	0.7	2.3	1.5	1.1	0.6	0.4	-0.4	0.1	-1.3	0.4	0.1	0.2	1.1	0.9
Eye problems/disorders: Cataract	0.5	0.6	2.0	1.4	1.2	0.7	0.1	-0.0	0.1	0.5	0.3	0.5	0.9	1.1	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	0.9	1.2	-1.1	-0.6	-0.9	0.4	-1.3	-0.6	-0.1	-0.2	0.0	-0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.4	0.2	0.5	1.4	1.5	0.4	-0.2	0.5	0.2	0.7	1.2	0.4	0.5
Age started oral contraceptive pill	0.5	0.7	4.5	-0.6	-0.5	-0.4	0.4	-0.8	1.2	0.0	2.1	-0.3	0.6	-0.3	-0.2
Cholesterol lowering medication	0.5	0.7	1.4	-1.0	-0.8	-1.0	-0.3	0.5	-0.1	-0.4	-1.0	-0.5	-0.8	-1.2	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.2	-0.9	-0.5	1.2	-0.1	-0.3	-1.5	0.1	-0.2	0.1	-0.2	-1.4	-0.8
Alcohol drinker status: Previous	0.5	0.5	2.6	0.4	0.2	1.0	0.3	-1.6	0.4	1.0	0.1	0.5	0.6	0.2	0.7
Bipolar Disorder (2018)	0.4	0.7	2.2	-0.1	-0.2	0.4	1.3	-0.0	0.6	-0.3	-1.2	-1.2	1.5	0.6	0.7
Body Mass Index (BMI) (2010)	0.4	0.6	3.2	0.7	0.9	0.6	0.1	-1.8	0.4	-0.5	0.3	-0.0	1.0	0.3	0.4
Lupus	0.4	0.5	2.3	1.1	1.5	-0.3	-0.1	-0.4	-0.1	-1.0	-0.8	0.4	-0.8	-0.3	0.2
Neuroticism (2016)	0.4	0.6	2.3	-0.0	0.3	0.4	-1.2	-0.7	0.5	0.5	-0.6	0.8	-1.5	-0.5	-1.0
Ulcerative Colitis	0.4	0.6	2.7	0.4	-0.4	-0.2	-0.8	1.7	-0.7	0.3	0.5	0.4	-0.5	0.9	1.2
Diabetes (father)	0.4	0.5	2.4	0.0	0.1	0.8	1.0	-0.6	-1.6	0.9	-0.3	0.9	-0.4	-0.3	0.3
Trunk fat percentage	0.4	1.7	5.3	0.9	1.0	2.0	1.8	-0.5	-0.4	1.1	0.3	1.2	2.3	1.1	1.5
Waist circumference	0.4	1.5	5.0	0.8	0.9	2.0	2.2	-0.9	0.9	0.5	0.5	0.3	2.0	0.8	1.0
Neuroticism score	0.4	0.7	2.0	-0.1	-0.5	1.4	-0.6	1.0	1.0	-1.4	-0.6	-1.2	-0.6	0.0	0.6
Father’s age at death	0.4	0.5	2.5	-0.7	-1.1	-0.4	-1.6	0.5	0.6	0.5	0.1	-0.3	-1.0	-0.1	0.0
Worrier / anxious feelings	0.4	0.7	1.5	0.4	-0.3	0.6	-0.3	1.1	0.9	-0.9	-1.2	-0.8	0.1	1.0	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.8	0.8	0.9	-0.8	-1.1	-0.6	0.2	-0.3	-1.3	0.3	-1.2	-0.6	-0.6
Medication: Cholesterol lowering	0.4	0.6	2.3	-0.3	0.1	-0.3	0.3	-1.5	0.8	-0.8	-0.5	-0.3	-0.2	-0.9	-1.2
Depression (self-reported)	0.4	0.5	1.1	1.1	0.8	-0.6	-0.3	-0.8	-0.7	-0.3	0.4	0.8	-0.9	1.0	0.3
Breastfed as a baby	0.4	0.5	2.1	0.6	0.7	-0.7	-1.4	-0.1	0.5	-0.8	0.2	-0.4	-1.2	-0.5	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.5	1.7	0.5	0.2	0.1	-0.1	0.7	-1.2	1.0	-1.3	0.9	-0.5	0.4	0.6
Loud music exposure frequency	0.4	0.4	1.8	0.2	0.2	-0.5	1.0	-0.3	1.3	0.7	0.2	0.5	0.8	0.3	0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.8	-0.2	-0.2	-1.3	-0.6	1.2	0.6	-1.1	-0.8	-1.0	-0.8	-0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.1	0.3	0.1	-0.7	-0.4	-0.4	-0.1	-0.7	-1.4	-0.0	-1.5	-0.4	-0.5
Health satisfaction	0.4	0.5	1.8	1.0	0.5	-0.1	-0.5	-0.4	-0.1	-1.0	-0.8	-0.6	-0.1	0.9	1.3
Mean time to correctly identify matches	0.4	0.7	1.5	1.0	0.4	0.8	-0.2	-0.8	1.2	-0.3	1.1	-0.3	0.6	1.1	1.0
Medication: Aspirin	0.4	0.5	3.3	0.8	0.8	-0.5	-0.4	-1.8	-0.1	0.1	0.1	1.0	-0.0	-0.3	-0.5
Loneliness, isolation	0.4	0.5	2.2	0.1	-0.4	0.5	-0.4	0.7	0.5	-1.5	-0.4	-1.0	-0.8	0.3	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.8	-0.2	0.2	1.2	0.4	-0.5	-0.1	-0.8	-0.1	-0.3	-0.9	-0.5	-1.3
Qualifications: nursing, teaching	0.4	0.7	2.9	0.3	-0.2	0.5	-1.1	1.1	0.6	-0.5	-1.7	-0.5	-1.2	0.5	0.5
Basal cell carcinoma (self-reported)	0.4	0.5	2.1	-0.0	0.0	0.4	0.1	0.8	-1.1	-1.4	-0.4	-0.8	-1.0	-0.3	0.3
Worry (Nagel 2018)	0.3	0.6	2.6	0.1	-0.4	0.3	-1.5	0.9	0.9	0.0	-1.6	-0.0	-0.9	-0.1	0.4
Ulcerative Colitis (UC)	0.3	0.6	2.2	0.2	-0.1	0.3	0.5	1.4	-0.6	-0.3	1.5	0.3	0.5	0.7	1.3
Age at First Birth	0.3	0.4	1.4	0.0	-0.3	0.5	0.5	-0.8	0.9	-0.7	1.2	-0.7	0.3	0.5	0.4
Fasting Glucose	0.3	0.4	2.7	0.0	0.5	0.5	0.4	-0.6	1.6	0.2	0.7	0.4	0.5	0.5	0.1
Chronotype (morning person)	0.3	0.8	2.2	0.8	0.5	-0.2	-0.3	-1.4	0.3	1.0	1.3	1.5	0.6	0.8	0.3
Supplements: Zinc	0.3	0.4	0.9	0.1	-0.7	0.1	0.3	0.9	-0.8	1.0	-0.2	0.5	-0.5	0.6	0.6
Relative age voice broke	0.3	0.4	1.2	0.7	0.2	0.2	-0.4	0.3	-0.0	1.1	-1.0	1.1	-0.6	0.3	0.7
Taking other prescription medications	0.3	0.4	1.4	0.7	0.7	0.5	-0.2	-1.2	-0.4	-0.0	-0.6	0.8	-1.0	-0.4	-0.4
Trunk fat mass	0.3	1.4	4.2	1.0	1.2	1.5	1.9	-0.2	-0.2	0.6	0.2	1.0	2.0	0.9	1.4
Past tobacco smoking	0.3	0.5	2.3	1.0	0.7	-0.3	0.4	-0.1	0.2	0.7	-0.3	0.9	0.1	0.5	1.5
Pain all over the body in last month	0.3	0.3	0.8	0.9	0.7	0.2	-0.4	-0.2	0.9	0.3	0.2	0.8	0.5	0.7	0.2
Time employed in main current job	0.3	0.3	2.0	0.1	0.3	-0.5	-0.3	-0.7	0.2	-0.7	-1.4	-0.1	-0.6	-0.5	-0.3
Lung cancer (father)	0.3	0.4	2.5	0.0	0.4	0.1	0.9	-0.2	0.7	-0.4	1.6	0.0	0.7	0.3	0.2
Exposure to tobacco smoke at home	0.3	0.3	1.0	0.4	0.3	0.7	-0.7	0.2	0.2	-0.2	-1.0	0.0	-0.9	0.4	0.4
Tense / ‘highly strung’	0.3	0.4	2.3	0.8	0.6	1.0	0.0	-0.2	-0.0	-0.1	-0.1	0.4	0.1	0.8	1.5
Medication: Paracetamol	0.3	0.5	2.8	-0.3	-0.1	0.4	0.3	0.8	-1.7	0.7	-1.1	0.2	0.1	-0.6	0.2
Worry too long after embarrassment	0.3	0.4	1.4	0.5	0.2	1.1	-1.2	-0.6	1.0	-0.3	-0.2	-0.4	-0.5	0.2	0.5
Wheeze or whistling in the chest in last year	0.3	0.5	3.1	-0.7	-0.5	-0.2	0.5	0.3	0.4	0.4	-1.0	0.3	-0.5	-0.9	-1.7
Knee pain experienced in last month	0.3	0.4	2.8	-0.5	-0.1	-0.5	0.2	0.9	-1.7	0.4	0.0	0.4	0.2	-0.7	-0.3
Illnesses of siblings: Diabetes	0.3	0.3	1.7	-0.0	0.5	-1.0	-0.4	-1.3	0.1	-0.4	-0.5	0.0	0.4	-0.2	-0.5
Smoking status: Previous	0.3	0.4	2.1	-0.6	-0.7	0.3	-0.4	0.4	0.5	-1.0	0.1	-1.4	0.2	0.3	-0.5
Illnesses of father: None of the above (group 1)	0.3	0.3	0.8	-0.4	-0.9	-0.4	0.0	0.7	0.9	0.9	-0.7	0.4	-0.3	-0.2	0.3
Guilty feelings	0.3	0.5	2.4	0.5	-0.1	0.3	-0.3	0.7	1.5	-0.4	0.3	-0.8	-0.4	0.7	0.8
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.3	-0.1	0.9	0.1	-0.2	0.4	0.6	-0.8	0.3	-0.8	-0.8	-0.6
Ever smoked	0.3	0.5	2.9	-0.7	-0.3	0.1	-0.6	-0.3	-0.8	0.3	0.7	0.2	0.0	-0.6	-1.7
Depressed Affect (Nagel 2018)	0.2	0.4	2.6	-0.0	0.1	1.6	0.9	0.5	0.3	-0.0	0.4	0.0	0.5	-0.1	0.3
Neuroticism (Nagel 2018)	0.2	0.4	1.5	0.7	0.3	0.5	-0.8	-0.1	0.8	-0.6	-1.2	-0.2	-0.6	-0.0	0.4
Irritable Bowel Disease (IBD)	0.2	0.5	2.8	-1.0	-0.9	0.1	0.4	1.7	-0.3	0.0	0.8	-0.1	0.4	-0.4	0.2
Reaction Time	0.2	0.3	1.3	1.1	0.8	0.2	-0.7	-0.8	-0.0	-0.3	0.5	0.3	-0.3	0.3	0.6
Waist Hip Ratio (WHR)	0.2	0.9	2.4	1.2	1.3	-0.5	-0.2	-1.0	0.1	0.8	-1.3	1.6	-1.3	-0.2	-0.5
Sensitivity / hurt feelings	0.2	0.4	1.6	-0.4	-0.3	0.1	-0.5	0.1	0.4	-0.4	-1.3	0.0	-0.4	-0.9	-1.0
Diabetes (mother)	0.2	0.3	1.1	0.3	0.2	0.3	-0.9	-0.2	-1.0	-0.6	-0.4	-0.3	-0.8	0.1	-0.1
Severe depression (siblings)	0.2	0.3	1.3	-0.1	-0.1	1.1	0.6	0.1	-0.9	0.5	-0.3	0.2	0.2	0.1	0.4
Sitting height	0.2	1.5	3.1	0.9	1.8	-1.7	1.0	0.9	-1.7	-1.6	1.5	0.3	-0.6	-0.8	-0.4
Weight	0.2	1.0	3.3	1.2	1.5	1.0	1.8	-0.2	0.3	-0.2	0.4	0.6	1.5	0.7	1.2
Illnesses of mother	0.2	0.3	1.0	0.4	0.5	-0.5	0.2	-1.0	-0.1	0.1	-0.8	0.4	-0.6	-0.1	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.0	0.4	0.0	0.1	-0.4	0.3	-0.7	-0.5	-0.2	-0.7	-0.4	0.5	1.0
Age at first live birth	0.2	0.4	3.3	-0.4	-0.4	-0.4	0.4	0.6	0.5	-0.2	1.8	-0.2	0.1	-0.1	0.4
Overall health rating	0.2	0.5	2.2	-0.6	-0.6	0.2	-0.4	-0.4	-0.5	-0.4	-0.8	-0.1	-1.5	-1.1	-0.8
Chest pain or discomfort	0.2	0.3	1.3	0.8	1.0	-0.3	-0.2	-1.1	-0.1	-0.5	-0.3	0.1	0.4	0.5	-0.6
Ever taken oral contraceptive pill	0.2	0.3	0.9	-0.1	0.0	0.3	0.5	-0.2	-0.2	-0.9	-0.7	-0.6	0.8	-0.3	-0.5
Arm fat-free mass (left)	0.2	1.1	3.1	1.3	1.6	0.2	1.8	-0.7	1.2	-0.6	1.0	0.6	1.0	0.4	0.7
Arm predicted mass (left)	0.2	1.1	3.5	1.4	1.6	0.1	1.9	-0.9	1.2	-0.6	1.0	0.6	0.9	0.5	0.7
Hair Pigment	0.1	3.0	8.0	1.0	0.8	2.7	2.3	-0.6	2.2	0.7	2.0	0.1	2.8	1.6	1.2
Hearing difficulty/problems with background noise	0.1	0.2	0.7	0.5	0.3	-0.3	-0.3	0.7	-0.8	-0.2	0.2	-0.1	0.1	0.6	0.8
Trunk fat-free mass	0.1	0.6	2.0	1.1	1.4	-1.3	0.5	0.7	0.2	-1.1	0.3	0.4	-0.6	-0.3	0.1
Trunk predicted mass	0.1	0.6	1.8	1.1	1.4	-1.4	0.5	0.7	0.2	-1.1	0.4	0.3	-0.7	-0.3	0.1
Arm fat-free mass (right)	0.1	0.5	1.9	0.5	0.8	-0.3	1.4	-0.4	1.2	-0.5	0.8	0.2	0.3	-0.2	0.0
Arm predicted mass (right)	0.1	0.6	2.8	0.5	0.8	-0.1	1.7	-0.3	1.2	-0.7	0.9	0.0	0.6	-0.2	0.1
Whole body fat-free mass	0.1	0.5	1.7	1.1	1.3	-0.8	0.8	0.3	0.7	-0.8	0.4	0.4	-0.2	-0.1	0.2
Leg fat-free mass (right)	0.1	0.5	1.4	1.2	1.2	-0.6	0.8	0.2	1.0	-0.2	0.5	0.8	0.0	0.2	0.5
Whole body water mass	0.1	0.5	1.5	1.0	1.2	-0.8	0.9	0.3	0.7	-0.8	0.5	0.4	-0.2	-0.2	0.2
Leg predicted mass (right)	0.1	0.5	1.4	1.2	1.2	-0.6	0.8	0.1	1.0	-0.2	0.5	0.8	0.0	0.2	0.5
Miserableness	0.1	0.2	0.7	-0.5	-0.3	0.0	-0.2	0.2	-0.0	-0.3	-0.7	-0.7	-0.0	-0.4	-0.8
Hearing aid user	0.1	0.1	0.9	-0.3	-0.5	-0.1	0.0	-0.0	-1.0	-0.2	0.3	-0.2	-0.0	-0.1	0.2
Medication: Paracetamol	0.1	0.2	0.5	0.2	0.4	0.4	0.7	0.2	-0.5	-0.0	-0.7	-0.2	0.6	-0.0	0.5
Basal metabolic rate	0.1	0.5	1.7	1.0	1.3	-0.5	1.0	0.3	0.5	-0.7	0.4	0.5	0.1	-0.1	0.4
Tanning	0.0	0.3	0.8	-0.4	-0.7	0.9	-0.2	-0.5	-0.4	0.0	0.1	0.5	-0.8	-0.2	-0.5
Leg fat-free mass (left)	0.0	0.2	0.7	0.5	0.7	-0.6	0.8	0.3	0.8	-0.3	0.2	0.4	0.0	-0.4	0.1
Leg predicted mass (left)	0.0	0.2	0.6	0.5	0.7	-0.7	0.7	0.3	0.8	-0.4	0.1	0.4	-0.0	-0.4	0.1

Hub : Genes

OBFC1

Models

Trait associations