Hub : Genes

OBFC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1210 0.0320 3.3e-06 0.038 0.049 0.032 0.050 0.050 1.6e-05 1.2e-06 8.4e-05 9.9e-07 8.4e-07
2 GTEx Cells Transformed fibroblasts 0.1420 0.0460 3.3e-04 0.071 NA 0.039 NA 0.056 5.2e-06 NA 6.6e-04 NA 5.0e-05
3 GTEx Esophagus Mucosa 0.1500 0.0540 6.0e-04 -0.004 NA 0.006 NA -0.004 8.4e-01 NA 1.1e-01 NA 8.8e-01
4 GTEx Esophagus Muscularis 0.0980 0.0450 9.5e-03 -0.003 NA -0.004 NA -0.004 5.8e-01 NA 6.5e-01 NA 6.6e-01
5 GTEx Muscle Skeletal 0.0800 0.0316 4.5e-03 0.024 NA 0.040 NA 0.032 1.8e-03 NA 7.8e-05 NA 3.8e-04
6 GTEx Thyroid 0.0940 0.0360 2.2e-03 -0.001 NA 0.006 NA 0.005 3.7e-01 NA 1.1e-01 NA 1.3e-01
7 METSIM Adipose 0.0595 0.0229 2.5e-04 0.053 0.032 0.036 0.035 0.043 2.3e-08 1.4e-05 3.3e-06 4.7e-06 3.7e-07
8 NTR Blood 0.0256 0.0117 1.1e-02 0.000 0.002 -0.001 0.003 -0.001 5.3e-01 6.4e-02 7.2e-01 3.9e-02 9.1e-01
9 YFS Blood 0.1059 0.0221 0.0e+00 0.051 0.073 0.075 0.069 0.076 2.9e-16 1.2e-22 2.7e-23 1.2e-21 8.3e-24
10 TCGA Brain Lower Grade Glioma 0.0422 0.0205 3.5e-04 0.041 0.029 0.033 NA 0.031 1.7e-05 2.9e-04 1.1e-04 NA 1.6e-04
11 TCGA Lung Squamous Cell Carcinoma 0.0317 0.0175 2.4e-03 0.015 0.012 0.010 NA 0.014 6.5e-03 1.3e-02 2.5e-02 NA 8.1e-03
12 TCGA Pheochromocytoma and Paraganglioma 0.1120 0.0590 5.0e-03 0.058 0.074 0.059 NA 0.069 2.5e-03 7.1e-04 2.3e-03 NA 1.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.4 0.7 2.2 -0.1 -0.2 0.4 1.3 -0.0 0.6 -0.3 -1.2 -1.2 1.5 0.6 0.7
Bipolar Disorder or Schizophrenia 1.2 2.9 9.9 1.5 1.2 2.2 2.2 -0.8 1.6 -0.3 -0.6 -0.8 3.1 2.1 1.8
Depressed Affect (Nagel 2018) 0.2 0.4 2.6 -0.0 0.1 1.6 0.9 0.5 0.3 -0.0 0.4 0.0 0.5 -0.1 0.3
Depression (Nagel 2018) 0.5 0.7 3.5 0.0 -0.2 -1.1 -1.0 1.2 -0.7 -0.1 -1.9 -0.1 -0.9 -0.0 -0.5
Intelligence (Savage-Jansen 2018) 0.6 2.0 7.1 1.2 0.5 -0.9 -0.3 -0.3 1.5 2.1 0.3 1.8 -0.1 2.0 2.7
Neuroticism (Nagel 2018) 0.2 0.4 1.5 0.7 0.3 0.5 -0.8 -0.1 0.8 -0.6 -1.2 -0.2 -0.6 -0.0 0.4
Schizophrenia (2018) 1.5 3.1 8.2 2.0 1.7 2.7 1.8 -1.0 1.5 0.5 0.2 0.5 2.9 2.2 1.7
Schizophrenia vs Biploar Disorder 1.7 2.2 8.0 1.6 1.5 2.8 0.4 -1.2 -1.8 1.3 1.2 2.2 0.2 0.8 0.5
Worry (Nagel 2018) 0.3 0.6 2.6 0.1 -0.4 0.3 -1.5 0.9 0.9 0.0 -1.6 -0.0 -0.9 -0.1 0.4
Alzheimer’s Disease (in mother) 1.2 1.4 4.4 0.0 -0.9 -0.2 -0.3 0.7 0.9 -0.9 2.1 -0.9 1.2 1.9 1.9
Alzheimer’s Disease (in father) 1.2 1.3 6.0 0.5 0.4 -0.1 1.8 0.3 2.5 -0.3 1.3 -0.6 1.6 1.1 0.3
Alzheimer’s Disease (including proxy) 2.0 2.8 7.3 0.3 -0.4 0.1 1.4 1.0 2.7 -0.9 2.4 -1.4 2.7 2.2 1.7
Crohns Disease (2017) 0.5 1.0 3.8 -1.9 -1.3 -0.4 -0.1 0.9 0.5 0.4 -0.3 -0.3 -0.1 -1.6 -1.5
Irritable Bowel Disease (IBD) 0.2 0.5 2.8 -1.0 -0.9 0.1 0.4 1.7 -0.3 0.0 0.8 -0.1 0.4 -0.4 0.2
Ulcerative Colitis (UC) 0.3 0.6 2.2 0.2 -0.1 0.3 0.5 1.4 -0.6 -0.3 1.5 0.3 0.5 0.7 1.3
Major Depression (MDD) 0.5 0.6 4.1 -0.0 -0.5 0.7 -0.4 0.1 -0.6 0.9 -2.0 0.7 -0.7 0.3 0.1
Reaction Time 0.2 0.3 1.3 1.1 0.8 0.2 -0.7 -0.8 -0.0 -0.3 0.5 0.3 -0.3 0.3 0.6
Verbal and Numeric Reasoning (VNR) 1.2 2.8 8.0 2.1 1.7 0.3 1.0 -1.7 2.0 0.7 0.3 1.0 1.6 2.5 2.8
Breast Cancer 0.6 1.5 4.3 1.2 1.0 0.7 0.5 -1.6 0.0 1.9 0.4 2.1 1.1 1.5 0.9
Ovarian Cancer 2.6 3.4 9.1 1.9 1.0 1.4 1.1 -1.4 1.9 0.7 2.5 0.7 1.9 3.0 2.8
Prostate Cancer 0.7 1.0 3.2 -1.3 -1.8 0.2 -0.6 0.8 0.4 -0.7 0.4 -1.4 -1.8 -0.4 -0.4
Age at First Birth 0.3 0.4 1.4 0.0 -0.3 0.5 0.5 -0.8 0.9 -0.7 1.2 -0.7 0.3 0.5 0.4
Bipolar Disorder (2011) 0.7 0.7 2.2 -0.8 -1.4 -1.5 -0.8 0.5 -0.3 0.0 -0.8 -1.2 0.1 0.6 0.2
Body Mass Index (BMI) (2010) 0.4 0.6 3.2 0.7 0.9 0.6 0.1 -1.8 0.4 -0.5 0.3 -0.0 1.0 0.3 0.4
Coronary Artery Disease (CAD) 4.3 5.2 10.5 2.9 3.2 2.6 1.2 -2.9 0.8 0.1 1.2 1.0 2.6 3.1 2.8
Crohns Disease (2012) 0.8 1.3 3.4 -1.5 -1.5 -0.6 -1.0 1.8 -0.3 0.7 -1.5 -0.1 -1.0 -1.2 -0.8
Mean Putamen Volume 0.7 0.8 3.6 1.3 0.9 -0.1 -0.2 0.2 -0.5 -0.7 1.2 0.3 -0.5 1.0 1.9
Fasting Glucose 0.3 0.4 2.7 0.0 0.5 0.5 0.4 -0.6 1.6 0.2 0.7 0.4 0.5 0.5 0.1
HbA1C 0.5 0.5 2.7 -0.5 -0.5 0.8 1.1 0.4 -0.5 0.4 1.6 0.5 0.4 -0.6 -0.2
HDL Cholesterol 0.7 1.2 3.6 0.5 0.6 0.8 1.5 -1.2 1.4 0.4 1.5 0.3 1.9 1.3 -0.1
LDL Cholesterol 0.6 0.9 3.5 -1.9 -1.6 0.3 1.0 0.8 -0.7 0.2 -0.3 -0.9 -0.1 -1.0 -1.1
Lupus 0.4 0.5 2.3 1.1 1.5 -0.3 -0.1 -0.4 -0.1 -1.0 -0.8 0.4 -0.8 -0.3 0.2
Neuroticism (2016) 0.4 0.6 2.3 -0.0 0.3 0.4 -1.2 -0.7 0.5 0.5 -0.6 0.8 -1.5 -0.5 -1.0
Primary Biliary Cirrhosis 0.5 0.7 3.6 -0.9 -0.3 -0.4 -0.4 -0.5 -0.6 0.0 -1.9 -0.5 0.3 -0.8 -1.5
Rheumatoid Arthritis 0.9 1.3 5.1 1.5 0.9 -2.3 -1.2 -0.4 -1.1 -0.4 0.6 0.4 -0.3 1.5 1.2
Schizophrenia (2014) 0.8 1.7 6.7 0.9 0.6 2.3 1.8 -0.3 0.7 0.5 -0.6 -0.4 2.6 1.5 0.7
Triglycerides 0.5 0.9 3.7 -1.0 -1.0 0.6 0.4 1.9 -0.9 -0.6 -0.6 -0.9 -0.3 -1.1 0.5
Type 2 Diabetes (T2D) (2012) 1.0 1.2 3.7 -1.2 -1.8 1.1 0.1 1.9 -0.1 -0.6 -0.7 -1.6 -0.2 -1.1 -0.3
Ulcerative Colitis 0.4 0.6 2.7 0.4 -0.4 -0.2 -0.8 1.7 -0.7 0.3 0.5 0.4 -0.5 0.9 1.2
Blood Eosinophil Count 0.7 5.0 9.8 2.8 3.1 1.5 1.5 -2.6 0.7 -0.4 3.0 1.2 2.9 2.9 1.6
Blood Platelet Count 1.7 20.2 51.3 -3.5 -1.6 -4.7 -4.5 2.8 -6.7 -2.5 -1.4 -1.1 -7.2 -6.0 -6.0
Blood Red Count 3.3 31.7 71.7 -8.5 -7.4 -3.5 -3.9 6.1 -0.6 -1.1 -3.9 -3.8 -6.6 -8.2 -6.9
Blood White Count 0.7 5.4 15.4 -1.5 -0.3 -1.4 -2.6 2.1 -3.7 0.1 -0.4 1.2 -3.9 -3.1 -3.0
Heel T-Score 0.5 3.7 18.0 1.0 -0.9 -0.3 -0.5 2.5 -1.3 -1.1 1.6 -1.6 -0.0 3.1 4.2
BMI 0.7 4.0 14.5 -0.1 -0.0 3.8 3.2 -0.4 2.3 0.9 0.9 -0.0 3.8 0.9 1.1
Height 0.8 15.5 44.9 2.8 3.0 -6.4 -4.1 4.0 -6.1 -1.1 -0.7 3.0 -6.7 -1.3 0.7
Waist Hip Ratio (WHR) 0.2 0.9 2.4 1.2 1.3 -0.5 -0.2 -1.0 0.1 0.8 -1.3 1.6 -1.3 -0.2 -0.5
Systolic Blood Pressure 5.7 28.4 58.4 -7.5 -6.7 -2.6 -5.3 5.3 -4.0 -0.2 -3.6 -2.3 -6.6 -7.6 -6.3
Smoking Status 0.5 1.2 4.5 -0.8 -0.4 1.3 -0.5 -0.2 0.1 -2.1 -0.1 -1.6 -0.6 -1.1 -1.7
Allergy or Eczema 0.8 2.1 8.9 -1.8 -1.8 0.0 2.3 3.0 1.1 0.3 -0.5 -1.6 0.6 -0.4 0.1
Cardiovascular Disease 2.9 9.5 18.5 -3.8 -3.5 -2.7 -4.1 1.5 -1.9 -0.4 -1.6 -1.2 -4.3 -4.1 -4.2
Hypothyroidism (self reported) 0.8 1.9 7.6 1.1 1.6 2.4 1.7 -0.8 -0.5 0.8 0.5 0.9 2.8 0.4 0.2
Respiratory disease 1.5 3.4 7.8 -2.7 -2.8 -0.3 0.8 1.9 2.0 -1.4 -1.8 -2.8 -0.6 -1.5 -1.5
Type 2 Diabetes (T2D) (2018) 0.6 1.2 3.4 0.8 1.4 0.8 1.4 -1.0 0.2 1.5 -1.0 1.9 0.2 -0.1 -0.9
Lung FEV1/FVC ratio 1.7 8.7 20.3 3.9 4.3 -1.2 -4.3 -2.1 -4.5 0.9 0.8 4.2 -2.6 0.3 0.5
Lung FVC 3.1 15.6 36.0 5.8 6.0 3.7 2.4 -5.6 -0.8 -0.0 3.1 3.3 2.9 4.2 4.5
Neuroticism 0.6 1.4 4.8 1.3 0.9 2.2 0.2 -0.1 1.2 -1.5 -0.3 -0.9 0.3 1.2 1.7
Chronotype (morning person) 0.3 0.8 2.2 0.8 0.5 -0.2 -0.3 -1.4 0.3 1.0 1.3 1.5 0.6 0.8 0.3
Hair Pigment 0.1 3.0 8.0 1.0 0.8 2.7 2.3 -0.6 2.2 0.7 2.0 0.1 2.8 1.6 1.2
Tanning 0.0 0.3 0.8 -0.4 -0.7 0.9 -0.2 -0.5 -0.4 0.0 0.1 0.5 -0.8 -0.2 -0.5
Hand grip strength (left) 0.9 2.3 12.1 -1.4 -0.4 -3.5 -0.1 1.5 -1.0 0.1 -1.8 0.1 -0.5 -1.7 -1.8
Number of treatments/medications taken 0.5 0.9 3.2 -0.6 -0.3 0.6 0.5 -0.8 0.6 -0.0 -1.8 0.4 -0.7 -1.6 -1.7
Average weekly spirits intake 0.6 0.7 2.5 -0.0 0.7 1.4 0.9 -0.1 -0.0 -0.5 -1.6 -0.7 1.1 -0.6 -0.7
Sensitivity / hurt feelings 0.2 0.4 1.6 -0.4 -0.3 0.1 -0.5 0.1 0.4 -0.4 -1.3 0.0 -0.4 -0.9 -1.0
Frequency of depressed mood in last 2 weeks 1.4 2.0 5.2 0.1 -0.6 -1.3 -1.7 2.3 -1.5 -1.8 -2.0 -1.5 -1.4 0.4 0.1
Hearing difficulty/problems: Yes 1.5 2.2 8.1 1.5 1.7 2.3 0.8 -0.8 -1.0 0.1 2.8 1.3 0.1 1.2 1.6
Relative age of first facial hair 0.9 1.8 6.3 0.7 0.3 -2.1 -2.1 0.7 -1.7 0.7 -0.7 1.3 -2.5 -0.3 0.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 2.1 1.4 0.8 -0.8 -0.4 -0.7 -0.9 -0.3 -0.6 0.6 -1.2 1.0 1.1
Ever used hormone-replacement therapy (HRT) 1.3 1.6 4.3 -1.7 -1.2 0.3 0.4 1.6 -1.6 1.6 -0.9 0.6 -0.2 -2.1 -1.4
Ever had hysterectomy (womb removed) 9.4 10.6 23.1 -4.0 -3.3 -2.8 -3.6 2.2 -2.8 -0.4 -1.4 -0.6 -4.8 -4.8 -4.3
Systolic blood pressure, automated reading 4.0 11.6 30.7 -5.5 -5.3 -0.9 -2.3 3.6 -0.8 0.8 -2.5 -2.1 -2.9 -4.8 -4.1
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.7 -0.4 0.5 -0.8 -0.8 -0.9 -0.9 0.7 -0.1 1.2 -1.6 -1.6 -1.5
Angina 3.0 4.0 12.1 3.5 2.9 0.1 0.2 -2.9 -0.1 -1.6 0.9 0.7 0.4 3.0 2.3
Medication for hormone replacement therapy 0.9 1.0 3.5 -0.8 -0.5 -1.9 -0.1 1.1 -1.2 -1.3 1.0 -1.2 0.3 -0.8 -0.8
Vitamin and mineral supplements 0.5 0.7 2.2 -0.4 -0.1 -0.8 -0.9 -1.2 -0.8 -0.3 -0.2 -0.3 -0.9 -1.3 -1.5
Supplements: Zinc 0.3 0.4 0.9 0.1 -0.7 0.1 0.3 0.9 -0.8 1.0 -0.2 0.5 -0.5 0.6 0.6
Medication: Co-codamol 1.2 1.4 4.4 -0.2 0.3 1.3 0.9 -0.4 2.1 -0.6 -2.1 -0.5 -0.3 -1.4 -1.5
Medication: Metformin 0.8 1.2 4.6 0.2 0.9 -0.5 0.5 -0.7 -0.2 1.8 -0.6 2.1 -0.5 -1.0 -1.8
Diabetes (father) 0.4 0.5 2.4 0.0 0.1 0.8 1.0 -0.6 -1.6 0.9 -0.3 0.9 -0.4 -0.3 0.3
Diabetes (mother) 0.2 0.3 1.1 0.3 0.2 0.3 -0.9 -0.2 -1.0 -0.6 -0.4 -0.3 -0.8 0.1 -0.1
Severe depression (siblings) 0.2 0.3 1.3 -0.1 -0.1 1.1 0.6 0.1 -0.9 0.5 -0.3 0.2 0.2 0.1 0.4
Pack years adult smoking proportion 0.8 1.3 5.6 -1.6 -1.7 0.8 -0.2 1.0 0.3 0.2 -2.4 -0.9 -0.5 -0.9 -0.7
Impedance of leg (right) 0.7 3.2 21.7 -0.1 0.2 -1.7 -2.1 0.6 -4.7 -0.4 -1.1 0.6 -2.4 -0.9 -0.5
Leg fat-free mass (left) 0.0 0.2 0.7 0.5 0.7 -0.6 0.8 0.3 0.8 -0.3 0.2 0.4 0.0 -0.4 0.1
Trunk fat percentage 0.4 1.7 5.3 0.9 1.0 2.0 1.8 -0.5 -0.4 1.1 0.3 1.2 2.3 1.1 1.5
Hand grip strength (right) 0.7 1.8 8.2 -1.2 -0.5 -2.9 -0.4 1.7 -1.2 -0.5 -1.8 -0.3 -0.7 -1.3 -1.2
Townsend deprivation index at recruitment 1.1 1.6 5.7 -1.2 -2.0 -1.1 -1.3 0.8 -0.2 -0.4 -0.7 -1.2 -2.4 -0.6 -1.5
Current tobacco smoking 1.8 3.0 9.0 -1.1 -0.3 -0.5 -2.1 0.5 -1.0 -1.1 -2.2 -0.5 -2.3 -3.0 -3.0
Average weekly fortified wine intake 0.7 0.8 4.0 -0.4 -0.6 0.5 1.1 0.4 2.0 -0.3 -0.4 -1.1 1.3 0.3 0.7
Maternal smoking around birth 1.3 1.8 5.9 1.0 1.0 1.8 1.8 0.1 0.8 -0.8 0.1 -0.6 2.4 2.0 1.5
Fed-up feelings 0.5 0.9 2.5 -0.7 -0.5 0.8 -1.0 1.6 -0.4 -0.1 -1.2 -0.4 -1.1 -1.3 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 4.7 -0.2 -0.7 -1.4 -1.7 0.9 -0.7 -0.9 -2.2 -0.8 -1.6 -0.4 -0.9
Relative age voice broke 0.3 0.4 1.2 0.7 0.2 0.2 -0.4 0.3 -0.0 1.1 -1.0 1.1 -0.6 0.3 0.7
Taking other prescription medications 0.3 0.4 1.4 0.7 0.7 0.5 -0.2 -1.2 -0.4 -0.0 -0.6 0.8 -1.0 -0.4 -0.4
Age when periods started (menarche) 1.0 2.3 12.7 -0.4 -0.1 -3.6 -1.7 0.4 -2.2 -0.7 -0.6 0.2 -1.9 -1.1 -0.8
Bilateral oophorectomy (both ovaries removed) 6.3 7.3 21.6 -4.2 -3.5 -1.4 -1.9 1.1 -1.4 -0.6 -0.3 -1.5 -3.5 -4.7 -3.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 5.8 0.7 -0.0 0.1 0.1 1.3 0.5 -0.5 0.4 -0.8 0.8 1.9 2.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.9 0.4 -0.0 0.2 1.5 0.2 0.7 0.0 0.9 -0.2 1.7 1.4 1.4
Qualifications: CSEs or equivalent 0.7 0.9 2.5 -1.6 -1.2 0.7 1.1 0.4 0.4 1.5 0.5 0.7 0.0 -1.2 -0.8
Serious illness, injury or assault to yourself 1.6 2.0 10.3 2.0 1.7 0.4 -0.2 -0.6 -3.2 -0.3 0.2 0.7 -1.3 1.2 1.5
High blood pressure 3.3 9.3 19.3 -4.3 -3.9 -2.6 -3.4 1.6 -0.6 1.0 -1.2 -0.7 -3.7 -4.4 -4.4
Hayfever, allergic rhinitis or eczema 0.6 1.2 5.6 -1.4 -1.2 0.1 1.2 2.4 1.2 0.6 -1.1 -0.8 -0.2 -0.8 0.0
Multivitamins +/- minerals 0.6 0.8 2.9 0.4 -0.1 1.0 1.1 1.2 0.4 -0.1 0.8 -0.1 0.6 1.3 1.7
Stomach or abdominal pain in last month 1.9 2.3 5.5 -2.3 -2.0 -0.5 0.9 1.7 -0.1 1.1 -1.6 0.2 -1.1 -2.4 -1.9
Supplements: Glucosamine 2.4 3.2 6.0 2.0 1.7 2.1 2.1 0.4 1.5 1.5 -0.0 1.7 2.5 2.3 1.9
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 6.5 -1.7 -1.8 2.1 2.5 -0.2 2.2 0.5 -0.6 -1.2 0.9 -0.3 -0.1
Medication: Atenolol 1.0 1.3 4.4 1.0 0.6 -1.7 -1.8 -1.1 -0.8 0.2 0.2 1.3 -2.1 0.2 0.1
Medication: Levothyroxine sodium 0.6 1.0 3.1 1.0 1.5 1.4 1.2 -1.3 0.0 0.3 0.1 0.9 1.8 -0.1 0.0
Sitting height 0.2 1.5 3.1 0.9 1.8 -1.7 1.0 0.9 -1.7 -1.6 1.5 0.3 -0.6 -0.8 -0.4
Chronic bronchitis/emphysema (father) 2.1 2.4 13.8 -0.3 -0.1 2.3 3.7 -0.1 1.0 0.4 0.7 -0.6 2.6 0.9 0.2
High blood pressure (mother) 3.0 4.3 8.1 -2.8 -2.8 -0.5 -2.4 2.4 -1.4 0.4 -1.1 -0.9 -2.8 -2.6 -2.3
Body mass index (BMI) 1.1 4.8 17.8 0.5 0.6 3.6 3.5 -1.3 2.7 0.8 0.9 -0.1 4.2 1.4 1.5
Impedance of leg (left) 0.6 2.7 18.8 1.3 1.4 -1.2 -1.8 -0.0 -4.3 -0.2 -0.2 1.3 -1.7 0.5 0.6
Leg predicted mass (left) 0.0 0.2 0.6 0.5 0.7 -0.7 0.7 0.3 0.8 -0.4 0.1 0.4 -0.0 -0.4 0.1
Trunk fat mass 0.3 1.4 4.2 1.0 1.2 1.5 1.9 -0.2 -0.2 0.6 0.2 1.0 2.0 0.9 1.4
Waist circumference 0.4 1.5 5.0 0.8 0.9 2.0 2.2 -0.9 0.9 0.5 0.5 0.3 2.0 0.8 1.0
Number of incorrect matches in round 0.5 0.9 4.1 -0.2 0.0 -2.0 -1.1 0.8 -0.7 -1.0 -0.6 -1.1 -0.3 -0.5 -0.9
Past tobacco smoking 0.3 0.5 2.3 1.0 0.7 -0.3 0.4 -0.1 0.2 0.7 -0.3 0.9 0.1 0.5 1.5
Alcohol usually taken with meals 0.9 1.5 8.9 1.2 -0.3 -0.6 -0.6 -0.0 0.4 0.7 0.8 0.3 0.4 2.4 3.0
Nervous feelings 1.2 2.2 4.7 -1.5 -2.1 -0.0 -1.0 1.8 1.2 -0.8 -2.2 -1.9 -1.7 -1.1 -0.8
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 6.6 -0.9 -1.2 -2.2 -2.1 1.8 -0.2 -0.7 -2.6 -1.3 -1.5 -1.0 -0.9
Hearing difficulty/problems with background noise 0.1 0.2 0.7 0.5 0.3 -0.3 -0.3 0.7 -0.8 -0.2 0.2 -0.1 0.1 0.6 0.8
Hair/balding pattern: Pattern 2 1.0 1.3 6.3 -1.0 -1.2 -1.2 -0.7 1.2 0.6 -0.3 -2.5 -1.2 -0.3 -1.2 -0.4
Had menopause 1.6 2.0 5.2 0.6 1.0 2.1 1.7 -1.8 0.6 1.2 1.8 1.0 2.3 0.8 0.9
Had other major operations 1.3 1.5 3.8 -0.9 -1.2 -0.2 -0.4 1.6 -1.0 2.0 -1.3 1.5 -1.3 -1.2 -1.1
Forced vital capacity (FVC) 1.6 6.3 19.4 3.9 4.4 0.2 0.1 -2.2 -3.4 -0.3 2.4 3.3 -1.3 1.2 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 7.2 0.8 0.2 1.3 1.1 1.7 1.0 0.3 0.9 -0.3 1.8 2.1 2.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 3.0 0.7 0.9 1.7 0.3 -0.7 -1.1 0.4 0.2 0.5 0.8 0.4 1.0
Qualifications: None of the above 0.5 1.1 4.3 -1.4 -0.9 1.0 0.1 -0.6 -0.9 0.0 1.1 -0.1 -0.5 -1.7 -2.1
Financial difficulties in last 2 years 1.3 1.7 5.3 0.1 -0.4 -0.9 -1.5 1.6 -2.1 -2.3 -1.1 -1.7 -1.2 -0.1 0.4
Mouth/teeth dental problems 5.2 8.0 17.6 2.0 2.1 4.1 4.1 -3.6 1.3 1.4 2.2 1.3 4.2 2.6 2.5
Heart attack 2.0 2.5 6.3 2.5 2.2 0.6 1.4 -1.3 -1.3 -0.9 0.7 0.1 1.2 2.3 2.3
Allergy 0.6 1.4 3.6 1.4 1.1 -0.3 -1.4 -1.9 -1.6 0.4 1.6 1.4 -0.0 0.9 0.6
Pain all over the body in last month 0.3 0.3 0.8 0.9 0.7 0.2 -0.4 -0.2 0.9 0.3 0.2 0.8 0.5 0.7 0.2
Diabetes (self-reported) 0.6 1.0 4.1 0.6 1.1 -0.2 0.6 -1.1 0.0 1.7 -0.8 2.0 -0.0 -0.5 -0.8
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 8.8 -1.8 -1.6 -0.4 0.3 2.1 0.8 3.0 -0.1 1.2 -0.6 -1.2 -0.7
Medication: Ramipril 0.5 0.7 2.4 -1.6 -1.3 -0.4 0.2 0.3 1.2 0.7 -0.6 -0.5 0.4 -0.8 -0.8
Medication: Simvastatin 0.8 1.2 3.1 -1.6 -1.3 -1.8 -0.4 0.3 0.7 -0.4 -1.4 -1.0 -0.1 -1.1 -1.6
Fluid intelligence score 0.9 1.8 4.9 1.8 1.6 -0.3 0.3 -1.6 0.8 0.7 -0.5 1.1 1.2 2.1 2.2
Illnesses of siblings 1.0 1.3 3.8 1.3 0.9 0.8 1.8 0.1 0.1 0.6 -1.0 0.4 1.3 1.7 1.9
Neuroticism score 0.4 0.7 2.0 -0.1 -0.5 1.4 -0.6 1.0 1.0 -1.4 -0.6 -1.2 -0.6 0.0 0.6
Weight 0.2 1.0 3.3 1.2 1.5 1.0 1.8 -0.2 0.3 -0.2 0.4 0.6 1.5 0.7 1.2
Impedance of arm (right) 1.4 6.5 35.4 0.6 0.5 -2.7 -3.6 1.7 -6.0 0.2 -1.0 1.7 -3.8 -0.8 -0.2
Arm fat percentage (right) 0.8 3.1 10.7 0.7 1.0 2.9 2.8 -0.8 0.5 1.6 0.7 1.2 3.3 1.1 1.3
Trunk fat-free mass 0.1 0.6 2.0 1.1 1.4 -1.3 0.5 0.7 0.2 -1.1 0.3 0.4 -0.6 -0.3 0.1
Hip circumference 0.6 2.6 6.4 1.5 1.8 2.1 2.3 -1.1 0.6 0.1 1.4 0.4 2.5 1.6 1.8
Time employed in main current job 0.3 0.3 2.0 0.1 0.3 -0.5 -0.3 -0.7 0.2 -0.7 -1.4 -0.1 -0.6 -0.5 -0.3
Alcohol intake versus 10 years previously 0.5 0.7 3.1 -0.4 -0.5 -0.6 0.1 -0.3 -0.6 -0.3 -1.3 0.5 -1.8 -1.3 -0.5
Father’s age at death 0.4 0.5 2.5 -0.7 -1.1 -0.4 -1.6 0.5 0.6 0.5 0.1 -0.3 -1.0 -0.1 0.0
Worrier / anxious feelings 0.4 0.7 1.5 0.4 -0.3 0.6 -0.3 1.1 0.9 -0.9 -1.2 -0.8 0.1 1.0 1.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.8 0.8 0.9 -0.8 -1.1 -0.6 0.2 -0.3 -1.3 0.3 -1.2 -0.6 -0.6
Falls in the last year 0.7 1.0 3.0 1.1 0.2 -0.6 -0.8 0.1 -1.2 -1.3 0.2 -0.9 -0.9 1.2 1.7
Hair/balding pattern: Pattern 3 0.7 1.0 3.7 -0.6 0.3 0.6 0.7 -1.6 0.7 1.0 1.2 0.9 0.4 -0.5 -1.9
Number of live births 0.5 0.7 4.0 -0.8 -0.9 0.3 1.0 0.9 0.3 2.0 0.7 0.3 -0.0 -0.2 -0.0
Forced expiratory volume in 1-second (FEV1) 2.4 8.2 22.2 4.3 4.7 0.1 -0.7 -2.2 -4.5 0.1 2.6 3.9 -1.2 1.5 2.5
Pulse rate 1.2 2.0 7.9 2.2 2.8 1.0 -0.9 -1.7 -0.4 0.4 0.5 2.0 -0.8 0.2 0.7
Happiness 1.1 1.3 4.5 1.5 1.3 0.7 0.5 -1.2 0.4 -2.1 0.2 -1.2 1.1 1.3 1.1
Noisy workplace 0.5 0.6 2.3 -1.0 -1.0 -0.8 0.4 0.3 1.5 0.0 0.0 -0.4 0.1 -0.9 -0.9
Qualifications: A levels/AS levels or equivalent 0.6 1.3 4.0 0.8 0.7 -1.6 -2.0 1.4 -0.6 0.9 -0.6 1.4 -1.3 0.0 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 5.6 1.7 2.4 0.3 0.4 -1.6 -0.1 0.4 0.8 1.2 1.6 0.7 0.4
Mouth/teeth dental problems: Dentures 2.1 3.6 14.0 -1.3 -1.4 -2.4 -3.7 2.2 -1.3 -0.5 -0.9 -0.5 -3.0 -1.3 -1.0
Asthma 1.5 3.0 8.6 -2.5 -2.2 0.1 0.7 1.2 1.4 -0.4 -2.9 -1.5 -0.3 -1.9 -2.4
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.6 13.6 1.4 1.3 1.7 1.5 -0.7 -3.7 -0.1 1.8 0.7 1.2 1.1 1.1
Medication: Cholesterol lowering 0.4 0.6 2.3 -0.3 0.1 -0.3 0.3 -1.5 0.8 -0.8 -0.5 -0.3 -0.2 -0.9 -1.2
Depression (self-reported) 0.4 0.5 1.1 1.1 0.8 -0.6 -0.3 -0.8 -0.7 -0.3 0.4 0.8 -0.9 1.0 0.3
Medication: Lansoprazole 0.7 0.8 2.5 -0.1 0.2 0.4 0.1 0.6 0.1 1.6 -1.3 1.5 -0.2 -1.0 -1.4
Prospective memory result 0.7 0.9 4.3 -0.9 -0.4 -1.2 -0.9 -0.1 -0.3 -0.0 -0.2 -0.1 -0.6 -1.5 -2.1
Lung cancer (father) 0.3 0.4 2.5 0.0 0.4 0.1 0.9 -0.2 0.7 -0.4 1.6 0.0 0.7 0.3 0.2
Illnesses of mother 0.2 0.3 1.0 0.4 0.5 -0.5 0.2 -1.0 -0.1 0.1 -0.8 0.4 -0.6 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.4 14.9 3.6 3.8 -0.3 -0.3 -1.5 -3.9 -0.5 1.9 2.9 -1.2 1.0 2.2
Pulse wave Arterial Stiffness index 1.3 1.5 4.7 -0.7 -0.9 -0.7 -2.2 0.6 -1.4 -1.6 -0.9 -1.8 -1.0 -0.8 -0.8
Impedance of arm (left) 1.5 6.8 30.7 -0.6 -0.7 -3.0 -3.7 2.5 -5.5 0.1 -0.9 0.7 -4.0 -1.5 -0.7
Arm fat mass (right) 0.7 2.9 9.7 1.1 1.3 2.5 2.8 -0.8 1.0 0.7 0.8 0.8 3.1 1.3 1.8
Trunk predicted mass 0.1 0.6 1.8 1.1 1.4 -1.4 0.5 0.7 0.2 -1.1 0.4 0.3 -0.7 -0.3 0.1
Standing height 1.0 9.7 31.7 1.6 2.0 -5.6 -3.4 2.4 -4.8 -1.9 -0.9 1.5 -5.5 -1.6 -0.5
Length of working week for main job 1.1 1.2 2.4 0.7 1.0 1.5 1.1 -1.1 1.2 -1.5 0.5 -0.9 1.3 0.3 1.2
Exposure to tobacco smoke at home 0.3 0.3 1.0 0.4 0.3 0.7 -0.7 0.2 0.2 -0.2 -1.0 0.0 -0.9 0.4 0.4
Breastfed as a baby 0.4 0.5 2.1 0.6 0.7 -0.7 -1.4 -0.1 0.5 -0.8 0.2 -0.4 -1.2 -0.5 -0.1
Tense / ‘highly strung’ 0.3 0.4 2.3 0.8 0.6 1.0 0.0 -0.2 -0.0 -0.1 -0.1 0.4 0.1 0.8 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.5 1.7 0.5 0.2 0.1 -0.1 0.7 -1.2 1.0 -1.3 0.9 -0.5 0.4 0.6
Hair/balding pattern: Pattern 4 1.3 3.1 9.0 3.0 2.7 2.6 0.6 -1.0 0.7 -0.7 1.2 0.6 1.6 2.3 1.7
Birth weight of first child 2.2 3.9 9.5 2.8 2.9 0.5 1.6 -2.1 0.3 1.5 1.7 3.1 0.8 2.0 2.1
Peak expiratory flow (PEF) 2.2 5.2 13.0 3.5 3.6 -0.8 -1.1 -0.8 -3.5 0.6 1.6 3.0 -0.2 2.1 2.4
Pulse wave reflection index 2.8 3.5 9.3 -2.3 -3.1 -2.4 -1.7 1.9 0.5 -1.4 -1.7 -2.8 -0.4 -1.0 -0.8
Ever highly irritable/argumentative for 2 days 0.2 0.3 1.0 0.4 0.0 0.1 -0.4 0.3 -0.7 -0.5 -0.2 -0.7 -0.4 0.5 1.0
Loud music exposure frequency 0.4 0.4 1.8 0.2 0.2 -0.5 1.0 -0.3 1.3 0.7 0.2 0.5 0.8 0.3 0.5
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.8 -0.2 -0.2 -1.3 -0.6 1.2 0.6 -1.1 -0.8 -1.0 -0.8 -0.2 -0.1
Mouth/teeth dental problems: Bleeding gums 1.9 2.4 6.8 -1.0 -1.0 -2.5 -1.9 1.9 -1.2 -0.7 -0.7 -0.2 -2.6 -1.6 -1.4
Blood clot in the leg (DVT) 0.5 0.7 1.9 1.3 1.0 0.5 0.2 0.1 -1.2 -0.1 -0.3 0.2 0.7 1.1 1.4
Medication: Paracetamol 0.3 0.5 2.8 -0.3 -0.1 0.4 0.3 0.8 -1.7 0.7 -1.1 0.2 0.1 -0.6 0.2
Headache pain in last month 1.7 2.9 6.6 -2.6 -2.3 -0.5 0.9 2.1 -1.8 -0.9 -1.2 -1.7 -0.6 -2.3 -1.6
Medication for cholesterol, blood pressure or diabetes 1.5 2.4 6.5 2.1 1.8 1.4 1.5 0.6 -0.7 0.5 0.4 0.9 1.9 2.2 2.5
Glaucoma (self-reported) 0.9 1.1 3.2 -1.3 -1.8 -0.6 -0.1 0.8 1.6 -0.3 -0.3 -1.6 1.2 0.3 0.1
Gout (self-reported) 0.9 1.3 7.4 -0.1 -0.7 -2.7 -1.6 0.2 -0.4 -0.2 -1.1 -0.4 -1.7 0.4 0.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 4.0 0.6 1.3 2.0 1.2 -1.2 -0.3 1.0 0.4 1.2 1.9 -0.4 -0.8
Medication: Amlodipine 4.9 6.9 13.8 -3.7 -3.7 -2.0 -3.0 2.5 -0.8 -0.8 -1.8 -1.9 -3.1 -3.4 -2.6
Medication: Ventolin 100micrograms inhaler 1.6 2.1 7.2 -1.7 -1.5 -0.5 0.4 1.5 0.2 -1.3 -2.7 -1.7 0.0 -1.3 -1.9
Birth weight 0.8 1.7 4.5 -1.7 -1.6 -1.3 0.7 1.9 -0.9 -0.3 2.1 -0.6 -1.2 -1.2 -0.7
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.2 -1.2 -1.3 0.5 1.2 0.4 1.4 1.1 -0.0 -0.3 1.5 -0.3 0.2
High blood pressure (siblings) 3.2 4.6 12.1 -3.5 -3.2 -0.9 -2.1 1.7 -0.7 -0.9 0.9 -1.6 -2.3 -2.8 -2.7
Forced vital capacity (FVC), Best measure 1.3 4.6 15.0 3.6 3.9 0.1 0.4 -1.7 -2.9 -1.5 1.6 1.9 -1.0 1.1 2.2
Body fat percentage 0.7 2.6 9.4 0.7 0.9 2.7 2.5 -0.8 0.1 1.2 0.5 1.0 3.1 1.1 1.5
Leg fat percentage (right) 0.9 3.1 13.4 0.1 0.4 3.3 3.0 -1.0 0.8 0.6 0.4 -0.0 3.7 0.9 1.1
Arm fat-free mass (right) 0.1 0.5 1.9 0.5 0.8 -0.3 1.4 -0.4 1.2 -0.5 0.8 0.2 0.3 -0.2 0.0
Exposure to tobacco smoke outside home 0.9 1.2 2.9 1.3 1.5 1.7 1.4 -1.3 0.1 -0.4 -0.0 0.5 1.0 1.0 1.0
Comparative body size at age 10 1.0 2.8 9.7 0.8 0.0 2.8 1.0 -0.8 3.1 0.7 0.4 -0.8 2.4 2.3 1.5
Number of full brothers 0.6 0.8 2.2 -0.3 0.1 -0.7 -1.0 -0.1 -0.8 -1.5 0.1 -0.9 -1.1 -1.1 -1.2
Worry too long after embarrassment 0.3 0.4 1.4 0.5 0.2 1.1 -1.2 -0.6 1.0 -0.3 -0.2 -0.4 -0.5 0.2 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.1 0.3 0.1 -0.7 -0.4 -0.4 -0.1 -0.7 -1.4 -0.0 -1.5 -0.4 -0.5
Wheeze or whistling in the chest in last year 0.3 0.5 3.1 -0.7 -0.5 -0.2 0.5 0.3 0.4 0.4 -1.0 0.3 -0.5 -0.9 -1.7
Number of children fathered 1.0 1.2 6.2 -0.2 -0.0 1.2 1.2 -0.1 1.0 0.1 1.6 -0.7 2.5 0.7 0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 6.8 -0.2 0.2 -1.2 -0.6 0.0 0.0 2.6 -0.7 2.2 -1.0 -1.2 -1.1
Age at first live birth 0.2 0.4 3.3 -0.4 -0.4 -0.4 0.4 0.6 0.5 -0.2 1.8 -0.2 0.1 -0.1 0.4
Pulse wave peak to peak time 1.0 1.1 3.8 0.7 1.1 0.1 1.8 -0.3 1.0 1.6 0.6 1.9 0.6 0.5 0.7
Health satisfaction 0.4 0.5 1.8 1.0 0.5 -0.1 -0.5 -0.4 -0.1 -1.0 -0.8 -0.6 -0.1 0.9 1.3
Shortness of breath walking on level ground 1.4 1.7 3.1 1.7 1.5 1.5 0.9 -1.6 0.5 1.3 1.0 1.8 1.0 1.1 1.1
Qualifications: College or University degree 0.6 1.8 4.2 1.2 1.1 -1.6 -1.6 0.6 -1.1 1.7 -1.1 2.0 -1.5 0.1 1.0
Eye problems/disorders: None of the above 0.8 1.0 2.4 -1.3 -0.8 -0.0 -0.2 0.1 -1.2 -1.3 0.3 -0.6 -1.3 -1.5 -1.5
Mouth/teeth dental problems: Loose teeth 1.2 1.4 5.0 -1.3 -0.2 -0.5 0.7 0.2 0.9 1.1 -1.4 0.8 0.0 -2.0 -2.2
Emphysema/chronic bronchitis 0.6 0.7 3.3 -0.2 0.3 0.8 0.3 -0.7 0.4 -1.8 -0.3 -1.0 0.0 -0.8 -1.4
Medication for pain relief, constipation, heartburn 0.7 1.2 6.0 -1.2 -1.1 -1.2 -0.7 1.1 2.5 -0.2 0.1 -0.7 -1.2 -0.4 -0.9
Neck or shoulder pain in last month 1.2 1.7 8.3 0.3 0.4 0.5 0.3 -0.5 -1.6 2.9 0.2 2.7 -0.8 -0.4 -0.4
Medication: Blood pressure 3.7 6.5 14.2 -3.8 -3.5 -2.3 -2.3 0.8 0.2 -0.9 -1.2 -1.8 -3.1 -3.6 -3.5
Angina (self-reported) 3.4 4.4 13.5 3.7 3.0 0.4 0.4 -3.2 -0.4 -1.5 1.0 0.8 0.5 3.2 2.4
Migraine (self-reported) 1.5 1.9 7.2 0.9 0.5 -0.8 1.4 -0.7 1.4 -0.5 1.5 -0.5 2.7 1.8 1.9
Medication: Ibuprofen 1.7 2.1 6.4 1.4 1.0 1.4 1.7 -1.0 -2.5 -0.6 1.7 0.1 1.5 1.5 1.6
Medication: Allopurinol 1.4 1.9 5.1 0.5 0.0 -2.2 -2.1 0.0 -1.3 0.7 -2.2 0.8 -2.3 0.5 0.4
Medication: Omeprazole 0.6 0.7 3.5 -1.0 -0.8 0.6 -0.2 0.7 -1.9 -0.6 0.2 -0.6 -0.3 -1.0 -0.2
Medication: Seretide 50 evohaler 1.6 1.8 8.0 -0.8 0.2 -0.3 -1.5 -1.2 -0.0 0.1 -1.1 0.7 -1.5 -2.2 -2.8
Mean time to correctly identify matches 0.4 0.7 1.5 1.0 0.4 0.8 -0.2 -0.8 1.2 -0.3 1.1 -0.3 0.6 1.1 1.0
Heart disease (mother) 2.7 3.3 9.6 3.1 2.6 -0.0 0.0 -1.9 0.5 -0.1 0.9 0.9 2.1 2.8 2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 8.5 -1.6 -1.9 -1.6 -1.5 2.9 1.0 0.6 -0.5 -0.4 -0.3 -0.6 -0.7
Whole body fat mass 0.6 2.3 7.4 1.1 1.3 2.2 2.5 -0.8 0.3 0.8 0.7 1.1 2.7 1.0 1.5
Leg fat mass (right) 0.6 2.5 10.0 0.6 0.8 2.4 2.9 -1.1 0.9 0.5 0.4 0.3 3.2 0.8 1.2
Arm predicted mass (right) 0.1 0.6 2.8 0.5 0.8 -0.1 1.7 -0.3 1.2 -0.7 0.9 0.0 0.6 -0.2 0.1
Pulse rate, automated reading 0.6 2.0 8.8 2.2 3.0 -0.3 -1.6 -1.3 -1.2 -1.0 -0.5 1.7 -1.0 0.0 -0.1
Alcohol intake frequency. 1.0 2.3 7.7 2.3 2.1 1.0 0.7 -2.8 -0.7 -0.9 -0.4 0.6 0.8 1.4 2.0
Comparative height size at age 10 0.5 2.9 8.4 0.9 0.9 -2.4 -2.3 1.8 -2.0 -2.4 0.6 -0.0 -2.9 -0.7 -0.4
Number of full sisters 0.5 0.7 2.3 1.0 0.2 0.0 -0.0 -0.8 0.6 0.9 0.9 0.7 0.8 1.5 0.9
Suffer from ‘nerves’ 0.8 1.3 4.4 0.8 -0.0 -0.5 -2.1 1.4 0.7 -1.4 -1.0 -1.1 -1.0 0.7 1.4
Overall health rating 0.2 0.5 2.2 -0.6 -0.6 0.2 -0.4 -0.4 -0.5 -0.4 -0.8 -0.1 -1.5 -1.1 -0.8
Chest pain or discomfort 0.2 0.3 1.3 0.8 1.0 -0.3 -0.2 -1.1 -0.1 -0.5 -0.3 0.1 0.4 0.5 -0.6
Had major operations 1.2 1.4 3.3 -1.2 -1.0 -1.1 -1.3 1.4 -0.7 -0.8 0.1 -0.9 -1.8 -1.8 -1.0
Age at last live birth 0.6 0.9 3.8 -1.0 -1.0 -0.5 0.4 2.0 0.8 -0.7 1.3 -1.2 -0.8 -0.5 -0.1
Family relationship satisfaction 1.0 1.3 4.7 1.3 1.0 1.1 0.8 -0.9 -0.5 -2.2 1.0 -0.7 0.4 1.0 1.5
Leg pain on walking 2.8 3.5 9.3 3.0 2.8 0.7 1.9 -1.6 0.8 -0.6 0.7 0.4 1.4 2.5 2.8
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.6 5.5 -1.8 -1.6 -0.2 0.8 -0.4 2.3 -0.3 -0.9 -1.6 1.3 -0.9 -1.3
Commuting to job workplace: Car/motor vehicle 0.6 0.6 2.3 -0.7 0.0 0.4 0.6 1.0 -1.5 -0.7 -1.1 -0.7 0.2 -0.9 -0.1
Illness, injury, bereavement, stress in last 2 years 1.4 1.8 5.2 -2.0 -2.1 -0.8 -0.1 -0.1 2.3 1.4 -1.1 -0.3 0.1 -1.2 -1.5
Medication: Aspirin 0.4 0.5 3.3 0.8 0.8 -0.5 -0.4 -1.8 -0.1 0.1 0.1 1.0 -0.0 -0.3 -0.5
Supplements: Vitamin C 1.0 1.2 3.5 0.9 0.5 1.9 0.4 0.5 0.1 1.4 0.3 1.3 0.9 1.4 1.6
Knee pain experienced in last month 0.3 0.4 2.8 -0.5 -0.1 -0.5 0.2 0.9 -1.7 0.4 0.0 0.4 0.2 -0.7 -0.3
Hypertension (Self-reported) 3.1 8.6 19.0 -4.2 -3.8 -2.4 -3.3 1.3 -0.6 0.4 -1.3 -1.1 -3.6 -4.2 -4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 5.6 -0.5 0.1 0.4 1.3 -0.9 -0.6 2.4 -0.2 2.1 0.7 -0.8 -0.8
Illnesses of father: Heart disease 2.4 3.3 10.7 2.6 2.4 0.4 -0.4 -3.3 -0.5 0.2 1.1 0.9 2.3 2.3 1.9
Illnesses of siblings: Diabetes 0.3 0.3 1.7 -0.0 0.5 -1.0 -0.4 -1.3 0.1 -0.4 -0.5 0.0 0.4 -0.2 -0.5
Smoking status: Previous 0.3 0.4 2.1 -0.6 -0.7 0.3 -0.4 0.4 0.5 -1.0 0.1 -1.4 0.2 0.3 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.8 5.3 1.2 1.0 -2.3 -1.4 1.5 -1.6 -0.3 -0.6 1.1 -2.0 0.3 0.8
Whole body fat-free mass 0.1 0.5 1.7 1.1 1.3 -0.8 0.8 0.3 0.7 -0.8 0.4 0.4 -0.2 -0.1 0.2
Leg fat-free mass (right) 0.1 0.5 1.4 1.2 1.2 -0.6 0.8 0.2 1.0 -0.2 0.5 0.8 0.0 0.2 0.5
Arm fat percentage (left) 0.6 2.4 9.7 0.2 0.5 2.7 2.6 -0.4 0.4 1.4 0.7 0.7 3.1 0.8 1.2
Average weekly red wine intake 0.7 1.0 2.8 -1.0 -1.1 -1.7 -1.7 1.0 -0.7 1.3 -0.3 0.4 -0.8 -0.8 -0.2
Handedness (chirality/laterality): Left-handed 1.4 1.7 4.3 1.7 1.3 1.8 0.8 -1.1 0.4 -0.0 0.3 0.3 1.7 2.1 1.7
Mood swings 0.6 1.0 4.5 1.0 1.0 2.1 0.9 -0.8 -0.2 -0.6 1.8 0.3 0.3 0.6 0.7
Loneliness, isolation 0.4 0.5 2.2 0.1 -0.4 0.5 -0.4 0.7 0.5 -1.5 -0.4 -1.0 -0.8 0.3 0.7
Long-standing illness, disability or infirmity 0.5 0.7 2.3 1.5 1.1 0.6 0.4 -0.4 0.1 -1.3 0.4 0.1 0.2 1.1 0.9
Ever had bowel cancer screening 0.7 0.8 3.4 -1.3 -1.8 -0.5 -0.3 0.4 1.4 0.8 0.3 -0.5 -0.6 -0.1 -0.7
Diabetes diagnosed by doctor 1.1 1.7 7.3 1.0 1.8 0.0 0.9 -1.8 0.0 2.1 -0.2 2.7 0.1 -0.3 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.8 -0.2 0.2 1.2 0.4 -0.5 -0.1 -0.8 -0.1 -0.3 -0.9 -0.5 -1.3
Friendships satisfaction 0.7 0.9 2.5 1.0 0.4 0.1 -0.2 -1.6 0.3 -1.4 0.7 -1.1 0.1 1.3 1.1
Qualifications: nursing, teaching 0.4 0.7 2.9 0.3 -0.2 0.5 -1.1 1.1 0.6 -0.5 -1.7 -0.5 -1.2 0.5 0.5
Commuting to job workplace: Walk 0.9 1.0 2.8 -0.8 -1.7 -0.8 -1.3 0.5 1.4 -0.6 -1.1 -1.2 -0.9 -0.1 -0.2
Eye problems/disorders: Cataract 0.5 0.6 2.0 1.4 1.2 0.7 0.1 -0.0 0.1 0.5 0.3 0.5 0.9 1.1 0.9
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.7 -1.0 -1.1 -1.5 -0.4 1.6 1.4 -0.7 -1.1 -1.1 -1.3 -1.3 -1.4
Medication for cholesterol 3.0 4.5 8.6 2.6 2.2 2.8 2.2 -1.7 2.0 0.3 1.0 1.1 2.0 2.9 2.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.7 0.9 1.2 -1.1 -0.6 -0.9 0.4 -1.3 -0.6 -0.1 -0.2 0.0 -0.1
Back pain experienced in last month 0.6 0.9 4.0 -0.6 -0.4 0.5 -0.5 2.0 -1.2 1.2 -0.8 1.0 -0.6 -0.8 -0.3
Mineral and other dietary supplements 1.2 1.6 5.4 -0.8 -1.4 -2.1 -2.3 -0.2 0.5 -0.8 -0.4 -1.4 -1.6 -0.7 -0.7
Breast cancer (self-reported) 1.1 1.3 4.7 0.5 1.2 -1.2 -0.6 -1.2 -0.4 0.8 -2.2 1.5 -0.4 -1.3 -1.0
Asthma (self-reported) 1.4 2.8 9.1 -2.2 -2.0 0.0 0.6 1.3 1.3 -0.6 -3.0 -1.5 -0.4 -1.8 -2.3
Osteoporosis (self-reported) 0.8 1.0 2.2 0.9 1.0 1.1 0.5 -1.4 0.7 -1.2 1.5 -0.3 0.8 0.9 0.8
Osteoarthritis (self-reported) 1.4 1.8 6.0 1.5 1.8 2.5 0.6 -0.5 0.4 -0.9 -1.2 -0.5 2.0 1.0 1.0
Medication: Aspirin 0.6 0.7 4.8 1.1 1.3 -0.3 -0.1 -2.2 -0.4 -0.2 0.1 0.9 0.2 -0.1 -0.4
Medication: Gliclazide 2.0 2.3 9.7 1.9 2.5 0.3 0.0 -2.0 -1.1 1.4 0.8 3.1 -0.2 0.2 -0.1
Illnesses of father: None of the above (group 1) 0.3 0.3 0.8 -0.4 -0.9 -0.4 0.0 0.7 0.9 0.9 -0.7 0.4 -0.3 -0.2 0.3
Smoking status: Current 2.3 3.7 11.2 -1.7 -0.9 -0.5 -1.9 0.8 -1.1 -1.5 -1.9 -1.1 -2.3 -3.3 -3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.9 10.3 27.2 5.2 5.0 1.8 1.4 -4.3 -1.8 -0.8 2.1 2.6 1.7 3.6 4.2
Whole body water mass 0.1 0.5 1.5 1.0 1.2 -0.8 0.9 0.3 0.7 -0.8 0.5 0.4 -0.2 -0.2 0.2
Leg predicted mass (right) 0.1 0.5 1.4 1.2 1.2 -0.6 0.8 0.1 1.0 -0.2 0.5 0.8 0.0 0.2 0.5
Arm fat mass (left) 0.6 2.6 8.8 1.0 1.2 2.4 2.7 -0.7 0.7 0.7 0.9 0.7 3.0 1.2 1.6
Number of self-reported non-cancer illnesses 1.3 2.2 6.8 -1.6 -1.3 -0.8 0.1 0.5 1.1 0.9 -2.6 0.1 -1.4 -2.2 -2.4
Average weekly champagne plus white wine intake 3.5 4.8 15.4 3.5 2.7 0.4 0.7 -1.4 1.4 0.3 1.6 1.7 1.5 3.9 3.2
Miserableness 0.1 0.2 0.7 -0.5 -0.3 0.0 -0.2 0.2 -0.0 -0.3 -0.7 -0.7 -0.0 -0.4 -0.8
Guilty feelings 0.3 0.5 2.4 0.5 -0.1 0.3 -0.3 0.7 1.5 -0.4 0.3 -0.8 -0.4 0.7 0.8
Wears glasses or contact lenses 1.2 1.4 3.1 0.8 0.7 1.7 1.6 -1.3 1.8 -0.0 1.0 -0.0 1.7 1.2 0.5
Ever taken oral contraceptive pill 0.2 0.3 0.9 -0.1 0.0 0.3 0.5 -0.2 -0.2 -0.9 -0.7 -0.6 0.8 -0.3 -0.5
Hearing aid user 0.1 0.1 0.9 -0.3 -0.5 -0.1 0.0 -0.0 -1.0 -0.2 0.3 -0.2 -0.0 -0.1 0.2
Mother’s age at death 0.9 1.1 4.4 0.6 0.4 0.7 0.9 0.7 0.1 -0.1 1.1 -0.7 2.1 1.7 1.5
Financial situation satisfaction 0.8 1.0 4.2 1.5 0.7 -0.1 -2.0 -0.2 -0.7 -1.1 -0.5 -0.1 -1.3 0.8 0.9
Tinnitus: Yes, now most or all of the time 1.2 1.5 5.2 -0.2 -0.2 -2.1 -2.3 0.1 -0.3 -1.4 -0.6 -0.7 -1.9 -0.8 -0.7
Commuting to job workplace: Public transport 0.3 0.3 0.7 -0.3 -0.1 0.9 0.1 -0.2 0.4 0.6 -0.8 0.3 -0.8 -0.8 -0.6
Eye problems/disorders: Glaucoma 1.3 1.5 6.4 -0.2 -1.0 -0.2 0.8 0.3 2.5 0.1 -0.1 -1.2 1.8 1.9 1.4
Medication: Blood pressure 1.4 2.7 5.2 -2.0 -2.0 -0.9 -2.3 1.2 -1.8 1.1 -0.9 0.0 -2.0 -2.0 -2.1
Pain type(s) experienced in last month: Hip pain 1.3 1.6 5.2 1.5 1.5 1.9 0.1 -0.7 0.4 -2.3 -1.9 -0.9 0.0 0.6 0.7
Supplements: Fish oil (including cod liver oil) 0.5 0.6 2.4 0.2 0.5 1.4 1.5 0.4 -0.2 0.5 0.2 0.7 1.2 0.4 0.5
High cholesterol (Self-reported) 0.8 1.3 3.3 -1.7 -1.8 -0.7 0.1 0.7 0.4 -0.6 -1.1 -1.3 -1.2 -1.3 -1.5
Medication: Bendroflumethiazide 3.8 5.8 11.3 -3.3 -3.4 -1.7 -2.5 2.7 -1.4 1.5 -1.7 -0.2 -3.0 -2.8 -2.6
Medication: Paracetamol 0.1 0.2 0.5 0.2 0.4 0.4 0.7 0.2 -0.5 -0.0 -0.7 -0.2 0.6 -0.0 0.5
Medication: Lisinopril 3.5 4.6 8.4 -2.6 -2.9 -2.6 -2.6 2.3 -1.3 -0.1 -2.1 -1.5 -2.3 -1.9 -1.9
Medication: Atorvastatin 0.8 0.9 4.7 0.5 0.7 0.1 -0.5 -1.5 -0.2 -0.1 -0.5 1.1 -2.2 -1.1 -0.7
Illnesses of father: High blood pressure 4.5 5.5 12.7 -3.3 -2.3 -0.6 -1.7 1.2 -1.1 -1.9 -1.6 -2.1 -3.0 -3.6 -3.5
Alcohol drinker status: Never 1.7 2.0 6.0 2.0 1.9 0.1 0.3 -1.6 -0.8 -0.7 2.5 1.0 0.7 1.7 1.5
Ever smoked 0.3 0.5 2.9 -0.7 -0.3 0.1 -0.6 -0.3 -0.8 0.3 0.7 0.2 0.0 -0.6 -1.7
Basal metabolic rate 0.1 0.5 1.7 1.0 1.3 -0.5 1.0 0.3 0.5 -0.7 0.4 0.5 0.1 -0.1 0.4
Leg fat percentage (left) 1.2 4.4 17.0 0.9 1.1 3.5 3.2 -1.3 1.3 0.8 1.0 0.5 4.1 1.7 1.7
Arm fat-free mass (left) 0.2 1.1 3.1 1.3 1.6 0.2 1.8 -0.7 1.2 -0.6 1.0 0.6 1.0 0.4 0.7
Number of operations (self-reported) 2.0 2.9 8.6 -1.6 -1.7 -1.7 -2.0 2.5 -1.4 0.1 -0.9 -0.5 -2.9 -1.8 -1.4
Average weekly beer plus cider intake 0.8 1.2 4.3 -1.3 -0.2 0.6 0.7 0.4 0.4 1.0 1.2 1.0 -0.6 -1.8 -2.1
Irritability 0.9 1.5 4.6 2.0 2.1 0.0 0.2 -1.0 -0.3 -0.4 0.1 0.4 1.5 1.7 1.7
Risk taking 0.6 0.8 4.1 -0.2 -0.2 -0.6 -0.5 1.3 -2.0 -0.1 -1.2 -0.5 0.6 -0.0 1.0
Ever had prostate specific antigen (PSA) test 2.4 2.8 9.7 -0.9 -1.1 -2.5 -2.7 1.0 0.7 -0.7 -1.3 -0.7 -3.1 -1.1 -1.7
Fractured/broken bones in last 5 years 0.7 0.9 2.2 1.3 1.1 0.5 -0.2 -1.2 0.5 0.6 1.1 1.0 0.9 0.9 1.5
Age started oral contraceptive pill 0.5 0.7 4.5 -0.6 -0.5 -0.4 0.4 -0.8 1.2 0.0 2.1 -0.3 0.6 -0.3 -0.2
Diastolic blood pressure, automated reading 1.7 5.3 11.8 -2.8 -2.4 -2.3 -2.1 2.4 -2.5 -0.3 -1.6 -1.2 -2.6 -3.4 -2.5
Ever depressed for a whole week 0.7 0.9 3.4 1.1 1.3 1.8 0.0 -1.3 0.2 -0.7 -0.3 -0.4 1.0 0.7 0.5
Unable to work because of sickness or disability 2.6 3.3 11.4 -0.8 -0.8 -2.2 -2.6 0.3 -0.8 -0.1 -2.5 0.6 -3.4 -2.1 -1.9
Commuting to job workplace: Cycle 0.9 1.0 2.5 -1.0 -0.9 -0.5 -1.1 0.0 -1.4 0.8 -0.7 0.4 -1.3 -1.3 -1.6
Myopia 1.4 2.0 6.3 2.5 2.0 -0.1 -1.8 -1.1 0.5 -0.2 0.7 0.7 0.4 2.2 1.8
Vascular/heart problems diagnosed by doctor 1.9 5.1 11.4 2.6 2.5 2.4 3.4 -0.6 0.5 0.0 1.0 0.7 3.2 2.9 3.2
Cholesterol lowering medication 0.5 0.7 1.4 -1.0 -0.8 -1.0 -0.3 0.5 -0.1 -0.4 -1.0 -0.5 -0.8 -1.2 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.2 -0.9 -0.5 1.2 -0.1 -0.3 -1.5 0.1 -0.2 0.1 -0.2 -1.4 -0.8
Pain experienced in last month 0.7 1.2 5.0 0.8 0.5 0.4 -0.3 -2.1 2.2 -1.1 0.6 -1.0 0.1 1.1 0.7
Supplements: Calcium 2.6 2.9 7.1 2.0 2.7 1.7 2.3 -1.3 -0.1 -0.2 1.3 1.1 2.1 1.5 1.9
Basal cell carcinoma (self-reported) 0.4 0.5 2.1 -0.0 0.0 0.4 0.1 0.8 -1.1 -1.4 -0.4 -0.8 -1.0 -0.3 0.3
Heart attack/myocardial infarction (self-reported) 1.5 2.0 4.9 2.2 2.0 0.5 1.3 -1.2 -1.3 -1.1 0.5 -0.2 1.0 2.0 1.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.4 1.3 1.0 0.4 0.1 0.0 -0.9 0.1 -0.1 0.4 0.8 1.4 1.5
Heart disease (siblings) 3.3 4.1 11.2 3.2 3.4 0.2 0.4 -3.2 1.2 -0.2 2.1 1.7 1.4 1.8 1.7
Alcohol drinker status: Previous 0.5 0.5 2.6 0.4 0.2 1.0 0.3 -1.6 0.4 1.0 0.1 0.5 0.6 0.2 0.7
Pack years of smoking 0.6 0.9 4.7 -1.1 -1.4 0.9 0.0 0.6 0.7 0.4 -2.2 -0.6 0.0 -0.5 -0.3
Impedance of whole body 1.0 5.0 27.3 0.1 0.0 -2.6 -3.3 1.4 -5.2 -0.1 -1.0 1.0 -3.3 -0.7 -0.2
Leg fat mass (left) 0.8 3.2 11.7 1.0 1.2 2.6 3.0 -1.3 1.2 0.7 0.8 0.6 3.4 1.3 1.6
Arm predicted mass (left) 0.2 1.1 3.5 1.4 1.6 0.1 1.9 -0.9 1.2 -0.6 1.0 0.6 0.9 0.5 0.7