TWAS hub - SCNM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0648	0.0321	0.00036	0.057	0.030	0.044	0.049	0.051	5.7e-09	2.2e-05	3.1e-07	7.1e-08	3.6e-08
2	YFS	Blood	0.0885	0.0305	0.00000	0.042	0.061	0.079	0.078	0.056	1.5e-13	3.0e-19	1.3e-24	3.8e-24	9.3e-18

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Impedance of arm (left)	8.5	39.3	39.7	6.3	6.2
Impedance of arm (right)	8.0	37.4	39.3	6.3	6.0
Impedance of whole body	7.1	36.1	40.7	5.6	6.4
Impedance of leg (right)	5.9	28.5	41.1	4.0	6.4
Impedance of leg (left)	5.3	25.9	36.5	3.9	6.0
Coronary Artery Disease (CAD)	5.2	6.3	9.4	3.1	1.8
Qualifications: CSEs or equivalent	4.5	5.9	9.2	1.6	3.0
Angina (self-reported)	4.5	5.9	7.1	2.7	2.2
Lung FVC	4.4	22.3	42.8	1.3	-6.5
Primary Biliary Cirrhosis	4.1	5.9	9.8	-1.4	-3.1
Angina	3.9	5.1	6.8	2.6	1.9
Intelligence (Savage-Jansen 2018)	3.7	11.4	12.7	3.6	3.2
Commuting to job workplace: Walk	3.6	3.9	6.8	1.0	2.6
Medication: Allopurinol	3.5	4.7	8.4	2.9	1.0
Blood Eosinophil Count	3.3	25.4	30.8	-4.5	-5.5
Pain experienced in last month	3.3	5.5	6.3	2.2	2.5
Medication: Ramipril	3.2	4.2	5.4	1.7	2.3
Miserableness	3.1	5.3	10.6	3.2	0.3
Fasting Glucose	2.9	3.4	6.7	2.6	-0.5
Heart attack	2.9	3.7	5.1	1.5	2.2
Gout (self-reported)	2.9	3.9	7.7	2.8	-0.4
Supplements: Calcium	2.9	3.2	4.0	1.6	2.0
Heart attack/myocardial infarction (self-reported)	2.9	3.7	5.2	1.5	2.3
Mother’s age at death	2.7	3.4	4.7	1.5	-2.2
Townsend deprivation index at recruitment	2.6	3.7	4.0	1.8	2.0
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	6.6	-1.3	-2.6
LDL Cholesterol	2.5	4.0	6.9	2.6	1.1
Blood Platelet Count	2.5	29.2	30.5	-5.5	-5.3
Allergy or Eczema	2.4	6.4	12.7	-0.1	3.6
Medication: Aspirin	2.4	3.1	5.5	0.9	2.4
Basal cell carcinoma (self-reported)	2.4	2.9	5.2	0.7	2.3
Eye problems/disorders: None of the above	2.2	2.6	5.0	-2.2	0.4
Average weekly champagne plus white wine intake	2.2	3.0	3.2	-1.7	-1.8
Waist Hip Ratio (WHR)	2.1	9.4	15.6	4.0	1.8
Medication: Cholesterol lowering	2.1	3.3	6.4	2.5	0.5
Vitamin and mineral supplements	2.0	2.7	4.1	-2.0	-1.2
Age when periods started (menarche)	2.0	4.7	5.9	-2.4	-1.9
Serious illness, injury or assault to yourself	2.0	2.4	4.8	0.3	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	4.5	2.1	0.4
Arm fat-free mass (left)	2.0	10.0	12.2	-3.5	-2.8
Chronotype (morning person)	1.9	4.4	8.7	0.1	3.0
Eye problems/disorders: Diabetes related eye disease	1.9	2.0	3.4	1.8	0.8
Number of incorrect matches in round	1.9	3.1	5.3	-2.3	-1.0
Birth weight of first child	1.9	3.4	5.9	-1.0	-2.4
Illnesses of father: Heart disease	1.9	2.6	2.9	1.7	1.6
Back pain experienced in last month	1.9	2.7	5.2	-0.6	-2.3
Guilty feelings	1.9	2.8	5.6	0.0	-2.4
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	3.8	1.0	1.9
Heart disease (siblings)	1.9	2.3	4.2	2.1	0.6
Verbal and Numeric Reasoning (VNR)	1.8	4.4	6.0	2.4	1.7
Noisy workplace	1.8	2.3	4.5	2.1	-0.2
Number of full brothers	1.8	2.3	2.5	1.6	1.4
Arm predicted mass (right)	1.8	9.2	11.6	-3.4	-2.6
Eye problems/disorders: Cataract	1.8	2.1	4.0	2.0	-0.4
Arm predicted mass (left)	1.8	9.3	12.1	-3.5	-2.6
Arm fat-free mass (right)	1.7	8.5	11.0	-3.3	-2.4
Exposure to tobacco smoke outside home	1.7	2.3	4.0	-0.8	2.0
Heart disease (mother)	1.7	2.1	4.0	2.0	-0.5
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	2.6	1.2	-1.6
Illnesses of father: High blood pressure	1.7	2.2	3.3	1.0	-1.8
HbA1C	1.6	1.7	3.2	0.5	-1.8
Happiness	1.6	2.0	3.2	-1.8	-0.9
Medication: Lansoprazole	1.6	1.8	1.8	1.4	1.4
Lung cancer (father)	1.6	1.8	2.6	-1.1	1.6
Worry too long after embarrassment	1.6	2.7	4.9	0.7	-2.2
Medication: Aspirin	1.6	2.1	3.9	0.6	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.5	4.2	1.7	-2.0
Tanning	1.5	17.9	28.1	-5.3	-2.8
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.8	1.7	1.0
Diabetes (father)	1.5	1.9	3.7	0.2	-1.9
Neuroticism score	1.5	3.2	6.1	2.5	-0.5
Mouth/teeth dental problems: Dentures	1.5	2.4	4.2	2.0	0.8
Loud music exposure frequency	1.5	1.6	3.1	0.2	1.8
Worry (Nagel 2018)	1.4	3.0	4.4	2.1	-1.2
HDL Cholesterol	1.4	2.3	4.3	-2.1	-0.5
Neuroticism	1.4	3.4	4.9	2.2	-1.4
Ever had hysterectomy (womb removed)	1.4	1.6	3.2	-1.8	0.3
Medication for hormone replacement therapy	1.4	1.6	3.2	1.8	0.1
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.3	-0.9	1.5
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.1	-0.2	2.5
Fluid intelligence score	1.4	2.9	3.9	2.0	1.4
Trunk fat-free mass	1.4	8.1	9.0	-3.0	-2.7
Illnesses of mother	1.4	1.7	2.8	-1.7	0.8
Trunk predicted mass	1.4	8.3	9.3	-3.0	-2.7
High blood pressure (siblings)	1.4	2.0	3.9	0.5	-2.0
Mouth/teeth dental problems: Loose teeth	1.4	1.6	1.9	1.2	-1.4
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.1	-1.4	1.0
Whole body fat-free mass	1.4	7.8	8.0	-2.8	-2.8
Whole body water mass	1.4	8.2	8.4	-2.9	-2.9
Wears glasses or contact lenses	1.4	1.7	3.1	0.5	1.8
Depressed Affect (Nagel 2018)	1.3	2.8	5.6	2.4	-0.3
Neuroticism (Nagel 2018)	1.3	3.2	5.4	2.3	-1.0
Breast Cancer	1.3	3.1	4.6	-1.2	-2.1
Bipolar Disorder (2011)	1.3	1.2	2.3	0.4	-1.5
Hypothyroidism (self reported)	1.3	2.9	5.8	0.2	-2.4
Medication: Co-codamol	1.3	1.5	2.2	1.5	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	4.0	-0.3	-2.0
Tense / ‘highly strung’	1.3	2.2	3.4	1.8	-1.0
Pulse wave peak to peak time	1.3	1.6	2.5	-0.8	1.6
Health satisfaction	1.3	1.7	2.9	0.7	-1.7
Medication for pain relief, constipation, heartburn	1.3	2.3	2.5	-1.4	-1.6
Mineral and other dietary supplements	1.3	1.7	3.4	-1.9	-0.2
Illnesses of father: None of the above (group 1)	1.3	1.6	3.1	-1.8	0.0
Crohns Disease (2017)	1.2	2.5	2.7	1.6	1.6
Lupus	1.2	1.9	3.6	0.3	-1.9
Blood White Count	1.2	8.7	15.2	-3.9	-1.5
Average weekly fortified wine intake	1.2	1.4	2.7	-1.6	0.3
Pulse wave Arterial Stiffness index	1.2	1.4	2.1	0.9	-1.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.0	-0.5	-1.7
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.5	1.0	-1.9
Leg fat-free mass (right)	1.2	6.2	7.4	-2.2	-2.7
Leg predicted mass (right)	1.2	6.2	7.4	-2.2	-2.7
Supplements: Fish oil (including cod liver oil)	1.2	1.5	3.0	1.7	-0.1
Medication: Bendroflumethiazide	1.2	1.9	3.8	-1.9	-0.1
Bipolar Disorder or Schizophrenia	1.1	2.7	3.0	1.5	-1.7
Irritable Bowel Disease (IBD)	1.1	2.6	3.6	1.3	1.9
Crohns Disease (2012)	1.1	1.8	2.4	1.1	1.5
Mean Putamen Volume	1.1	1.3	1.5	1.0	1.2
Pain all over the body in last month	1.1	1.2	1.5	0.9	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.5	0.0	1.6
Length of working week for main job	1.1	1.2	2.3	-1.5	0.3
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.5	-1.6	0.2
Glaucoma (self-reported)	1.1	1.3	2.2	-0.7	1.5
Medication: Amlodipine	1.1	1.6	3.1	0.3	1.8
Forced vital capacity (FVC), Best measure	1.1	4.1	6.9	1.1	-2.6
Medication: Omeprazole	1.1	1.4	2.2	0.7	1.5
Comparative height size at age 10	1.1	5.9	6.2	2.3	2.5
Suffer from ‘nerves’	1.1	1.7	2.9	1.7	-0.7
Long-standing illness, disability or infirmity	1.1	1.7	1.8	1.3	1.4
Commuting to job workplace: Public transport	1.1	1.3	1.9	1.4	-0.9
Number of treatments/medications taken	1.0	1.8	3.0	1.7	0.9
Multivitamins +/- minerals	1.0	1.3	2.4	1.5	0.5
Forced vital capacity (FVC)	1.0	4.0	5.8	1.5	-2.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.0	-1.4	0.7
Worrier / anxious feelings	1.0	1.9	2.3	1.5	-1.2
Had major operations	1.0	1.1	1.7	0.8	1.3
Supplements: Vitamin C	1.0	1.1	2.2	1.5	0.2
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.3	-0.4	1.5
Basal metabolic rate	1.0	5.8	6.1	-2.5	-2.3
Average weekly spirits intake	0.9	1.2	1.6	-1.3	-0.9
Leg fat-free mass (left)	0.9	4.8	5.2	-2.1	-2.3
Trunk fat percentage	0.9	3.6	5.3	1.3	2.3
Fed-up feelings	0.9	1.6	1.9	1.4	1.1
Chronic bronchitis/emphysema (father)	0.9	1.0	1.4	-0.8	1.2
Hair/balding pattern: Pattern 2	0.9	1.1	1.2	1.1	-1.0
Falls in the last year	0.9	1.3	2.5	0.0	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	2.0	0.2	-1.4
Neck or shoulder pain in last month	0.9	1.3	1.7	-1.3	-1.0
Osteoarthritis (self-reported)	0.9	1.1	2.0	-0.4	1.4
Medication: Lisinopril	0.9	1.1	2.3	0.0	-1.5
Alzheimer’s Disease (in mother)	0.8	0.9	1.3	-1.1	0.7
Schizophrenia (2014)	0.8	1.7	1.8	1.3	-1.3
Relative age voice broke	0.8	1.1	1.2	-1.1	1.0
Medication: Levothyroxine sodium	0.8	1.4	2.5	0.6	-1.6
Body mass index (BMI)	0.8	3.5	4.2	-2.0	-1.7
Leg predicted mass (left)	0.8	4.5	4.8	-2.0	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	1.4	1.0	1.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.5	-1.6	-0.3
Body fat percentage	0.8	3.1	4.4	1.3	2.1
Emphysema/chronic bronchitis	0.8	0.9	1.7	0.4	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.2	-0.4	1.8
Schizophrenia (2018)	0.7	1.5	1.6	1.2	-1.3
Smoking Status	0.7	1.8	1.8	-1.3	-1.3
Diabetes (mother)	0.7	0.9	1.8	-0.2	-1.3
Taking other prescription medications	0.7	1.1	1.4	0.9	1.2
Medication: Simvastatin	0.7	1.1	2.1	1.4	0.3
Number of live births	0.7	1.0	2.0	0.3	-1.4
Depression (self-reported)	0.7	0.8	1.6	1.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	0.8	-0.9	0.8
Age started oral contraceptive pill	0.7	0.9	1.0	-0.9	-1.0
Ovarian Cancer	0.6	0.9	1.7	1.3	-0.1
Age at First Birth	0.6	0.8	1.6	1.2	-0.4
Neuroticism (2016)	0.6	0.8	1.5	1.2	0.2
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.0	1.0	-0.5
Sensitivity / hurt feelings	0.6	1.1	2.0	1.4	0.4
Hearing difficulty/problems: Yes	0.6	0.9	1.5	1.2	-0.6
Stomach or abdominal pain in last month	0.6	0.7	1.1	-1.1	-0.6
Illnesses of siblings	0.6	0.9	1.1	-1.1	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.7	1.3	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.7	-0.0	1.3
Medication: Ibuprofen	0.6	0.7	1.4	1.2	0.3
Pulse rate, automated reading	0.6	1.8	3.4	-1.9	-0.4
Family relationship satisfaction	0.6	0.8	1.1	-1.1	-0.7
Smoking status: Previous	0.6	1.0	1.7	-1.3	-0.4
Breast cancer (self-reported)	0.6	0.7	1.2	-1.1	0.3
Osteoporosis (self-reported)	0.6	0.7	0.9	0.7	1.0
Unable to work because of sickness or disability	0.6	0.8	1.5	0.1	1.2
Bipolar Disorder (2018)	0.5	0.8	1.3	0.5	-1.1
Schizophrenia vs Biploar Disorder	0.5	0.7	1.1	0.5	1.0
Ulcerative Colitis (UC)	0.5	1.0	1.6	0.6	1.2
Body Mass Index (BMI) (2010)	0.5	0.7	0.7	-0.8	0.9
BMI	0.5	3.2	3.3	-1.8	-1.8
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.3	-0.1	1.1
Supplements: Zinc	0.5	0.5	1.0	1.0	0.3
Pack years adult smoking proportion	0.5	0.7	1.1	0.6	1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	2.6	0.7	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	2.8	0.8	-1.7
Headache pain in last month	0.5	0.8	1.4	-0.5	-1.2
Birth weight	0.5	1.1	2.2	1.5	-0.0
Shortness of breath walking on level ground	0.5	0.6	1.2	0.3	-1.1
Medication: Gliclazide	0.5	0.5	0.5	-0.7	0.7
Number of self-reported non-cancer illnesses	0.5	0.9	1.0	1.0	0.9
Ever taken oral contraceptive pill	0.5	0.5	1.1	0.1	-1.0
Medication: Atorvastatin	0.5	0.6	1.1	1.0	0.3
Number of operations (self-reported)	0.5	0.8	1.5	-1.2	-0.1
Heel T-Score	0.4	3.5	5.0	1.4	-2.2
Hand grip strength (left)	0.4	1.2	1.3	-1.0	-1.1
Relative age of first facial hair	0.4	0.9	1.6	0.4	1.3
Severe depression (siblings)	0.4	0.4	0.8	-0.2	0.9
Hand grip strength (right)	0.4	1.0	1.4	-1.2	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.9	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.5	-0.7	-0.6
High blood pressure (mother)	0.4	0.5	0.9	1.0	-0.3
Past tobacco smoking	0.4	0.8	1.3	1.1	0.5
Hearing difficulty/problems with background noise	0.4	0.7	1.1	0.6	-1.1
Time employed in main current job	0.4	0.5	0.7	-0.4	-0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.1	0.8	1.1
Prospective memory result	0.4	0.5	0.5	-0.6	-0.7
Standing height	0.4	3.7	4.5	1.7	2.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	1.0	0.3
Leg fat percentage (right)	0.4	1.5	2.9	0.3	1.7
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	-0.1	-1.2
Medication: Seretide 50 evohaler	0.4	0.5	0.6	0.7	0.6
Chest pain or discomfort	0.4	0.6	1.1	1.0	0.5
Medication for cholesterol	0.4	0.6	1.1	-1.0	0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	-0.3	-1.0
Medication: Blood pressure	0.4	0.7	1.1	-1.0	0.6
Ever smoked	0.4	0.6	0.8	-0.9	-0.6
Risk taking	0.4	0.5	1.0	-1.0	0.2
Alcohol drinker status: Previous	0.4	0.5	0.7	0.4	0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.4	0.4	-0.7
Height	0.3	4.9	5.6	2.0	2.4
Respiratory disease	0.3	0.6	1.0	1.0	0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.0	1.0	-0.4
Supplements: Glucosamine	0.3	0.4	0.6	0.7	0.4
Trunk fat mass	0.3	1.2	2.1	0.5	1.4
Mouth/teeth dental problems	0.3	0.4	0.6	-0.5	0.8
Allergy	0.3	0.6	1.1	-0.3	-1.0
Alcohol intake versus 10 years previously	0.3	0.4	0.7	0.9	-0.3
Exposure to tobacco smoke at home	0.3	0.3	0.4	0.4	-0.7
Hair/balding pattern: Pattern 4	0.3	0.7	1.0	-0.5	1.0
Blood clot in the leg (DVT)	0.3	0.4	0.6	-0.8	0.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.4	0.4	0.7
Comparative body size at age 10	0.3	0.8	1.0	-0.7	1.0
Alcohol intake frequency.	0.3	0.6	0.8	0.6	0.9
Illnesses of siblings: Diabetes	0.3	0.4	0.8	0.9	0.0
Arm fat percentage (left)	0.3	1.0	1.3	1.1	0.9
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.4	0.7
Medication: Paracetamol	0.3	0.4	0.8	-0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.5	-0.7	0.5
Depression (Nagel 2018)	0.2	0.3	0.7	0.2	-0.8
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	-0.7	-0.4
Current tobacco smoking	0.2	0.4	0.5	0.7	0.5
Alcohol usually taken with meals	0.2	0.3	0.4	-0.6	0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	-0.7	0.1
Qualifications: None of the above	0.2	0.5	0.7	-0.5	-0.8
Weight	0.2	0.8	1.2	-1.1	-0.6
Arm fat percentage (right)	0.2	0.8	1.1	1.0	0.7
Father’s age at death	0.2	0.3	0.5	0.1	-0.7
Pulse rate	0.2	0.3	0.3	-0.6	-0.5
Asthma	0.2	0.5	0.7	0.9	-0.5
Breastfed as a baby	0.2	0.2	0.3	0.6	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	0.4	-0.6
Qualifications: College or University degree	0.2	0.7	0.8	0.7	0.9
Migraine (self-reported)	0.2	0.2	0.4	0.1	0.6
Mean time to correctly identify matches	0.2	0.3	0.6	0.1	0.8
Number of full sisters	0.2	0.3	0.5	0.7	-0.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	0.7	-0.3
Loneliness, isolation	0.2	0.2	0.4	0.6	-0.3
Ever had bowel cancer screening	0.2	0.2	0.4	0.6	-0.3
Friendships satisfaction	0.2	0.3	0.5	-0.0	0.7
High cholesterol (Self-reported)	0.2	0.4	0.7	0.8	0.2
Leg fat percentage (left)	0.2	0.7	1.4	0.0	1.2
Average weekly beer plus cider intake	0.2	0.3	0.5	0.3	-0.7
Irritability	0.2	0.3	0.3	0.5	-0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.3	0.6
Diastolic blood pressure, automated reading	0.2	0.7	1.4	-0.3	-1.2
Pack years of smoking	0.2	0.3	0.5	0.3	0.7
Reaction Time	0.1	0.3	0.4	-0.4	0.6
Prostate Cancer	0.1	0.2	0.3	-0.6	0.2
Triglycerides	0.1	0.1	0.3	0.5	0.1
Ulcerative Colitis	0.1	0.1	0.2	-0.3	0.4
Blood Red Count	0.1	0.9	1.2	-0.8	1.1
Lung FEV1/FVC ratio	0.1	0.7	1.2	0.4	1.1
Hair Pigment	0.1	3.7	5.8	-1.2	-2.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.0	-0.5
Medication: Metformin	0.1	0.1	0.1	0.4	0.1
Maternal smoking around birth	0.1	0.2	0.3	0.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	0.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	0.6	0.4
Medication: Atenolol	0.1	0.1	0.1	-0.0	-0.4
Waist circumference	0.1	0.3	0.4	0.6	-0.4
Nervous feelings	0.1	0.1	0.2	0.2	-0.5
Had other major operations	0.1	0.2	0.3	0.0	-0.6
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.4	-0.2
Diabetes (self-reported)	0.1	0.2	0.3	0.5	-0.3
Hip circumference	0.1	0.6	0.7	-0.7	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.4	0.3
Peak expiratory flow (PEF)	0.1	0.1	0.2	-0.3	-0.5
Age at first live birth	0.1	0.1	0.2	0.3	0.4
Medication: Blood pressure	0.1	0.2	0.4	0.3	0.6
Whole body fat mass	0.1	0.5	0.8	0.4	0.9
Leg fat mass (right)	0.1	0.4	0.6	-0.4	0.7
Overall health rating	0.1	0.3	0.3	0.6	0.4
Leg pain on walking	0.1	0.1	0.1	0.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.1	0.5
Knee pain experienced in last month	0.1	0.1	0.1	-0.4	-0.3
Mood swings	0.1	0.1	0.2	0.5	0.3
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.6	-0.3
Asthma (self-reported)	0.1	0.2	0.3	0.5	-0.3
Smoking status: Current	0.1	0.1	0.2	0.4	0.2
Hearing aid user	0.1	0.1	0.2	0.3	0.4
Financial situation satisfaction	0.1	0.1	0.3	-0.5	0.1
Ever depressed for a whole week	0.1	0.1	0.2	-0.0	0.4
Myopia	0.1	0.2	0.4	0.1	-0.6
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	-0.4	-0.7
Cholesterol lowering medication	0.1	0.2	0.3	0.1	0.6
Leg fat mass (left)	0.1	0.2	0.3	-0.5	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.2	-0.2
Rheumatoid Arthritis	0.0	0.0	0.0	-0.2	-0.2
Systolic Blood Pressure	0.0	0.2	0.3	0.1	0.6
Cardiovascular Disease	0.0	0.1	0.2	0.5	-0.2
Systolic blood pressure, automated reading	0.0	0.0	0.1	-0.2	-0.2
High blood pressure	0.0	0.0	0.0	-0.1	0.1
Sitting height	0.0	0.1	0.2	-0.2	0.4
Had menopause	0.0	0.0	0.1	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	0.4	-0.3
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.0	-0.0
Arm fat mass (right)	0.0	0.1	0.2	-0.4	-0.3
Pulse wave reflection index	0.0	0.0	0.0	0.1	-0.2
Medication: Paracetamol	0.0	0.1	0.1	-0.1	-0.3
Number of children fathered	0.0	0.0	0.0	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.1	-0.0
Age at last live birth	0.0	0.0	0.0	-0.2	-0.2
Hypertension (Self-reported)	0.0	0.0	0.0	0.1	-0.0
Average weekly red wine intake	0.0	0.0	0.1	-0.0	-0.3
Qualifications: nursing, teaching	0.0	0.0	0.0	0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	0.1	0.3
Arm fat mass (left)	0.0	0.1	0.1	-0.4	-0.2
Alcohol drinker status: Never	0.0	0.0	0.0	0.2	-0.0
Fractured/broken bones in last 5 years	0.0	0.0	0.1	0.3	0.0
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.2	0.1

Hub : Genes

SCNM1

Models

Trait associations