[Hub]/) : Traits : Leg fat mass (left) : ← →

chr12:121,194,565-125,270,773

Best TWAS P=9.65e-17 · Best GWAS P=1.16e-20 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Adipose Visceral Omentum	CCDC92	0.19	0.02	lasso	8	0.09	3.3e-05	5.6	8.3	9.7e-17	-0.12	0.07	0.91	TRUE
49	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLXIP	0.06	0.02	blup	68	0.04	1.2e-03	7.0	7.9	3.9e-15	-0.23	0.02	0.85	TRUE
13	GTEx	Cells Transformed fibroblasts	BCL7A	0.06	0.01	lasso	4	0.01	3.1e-02	4.8	-7.8	4.7e-15	0.24	0.09	0.05	TRUE
18	GTEx	Esophagus Mucosa	HIP1R	0.21	0.05	lasso	5	0.07	1.5e-05	4.1	7.8	6.0e-15	-0.21	0.47	0.26	TRUE
51	The Cancer Genome Atlas	Thyroid Carcinoma	VPS33A	0.06	0.00	enet	8	0.03	9.6e-04	5.6	-6.9	6.2e-12	0.20	0.06	0.93	TRUE
25	GTEx	Muscle Skeletal	RSRC2	0.06	0.03	enet	7	0.04	9.6e-05	-3.3	-6.4	1.4e-10	0.43	0.25	0.48	TRUE
12	GTEx	Breast Mammary Tissue (Female)	C12orf65	0.06	0.00	enet	13	-0.01	6.5e-01	-4.2	-6.2	6.3e-10	0.27	0.04	0.16	TRUE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS33A	0.01	0.02	lasso	2	0.02	2.7e-04	6.0	-6.0	1.8e-09	0.14	0.16	0.64	TRUE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC43	0.03	0.03	enet	8	0.02	1.5e-03	-4.6	-6.0	1.8e-09	0.15	0.10	0.08	TRUE
10	GTEx	Brain Putamen basal ganglia	WDR66	0.25	0.01	enet	16	-0.01	5.6e-01	6.6	-5.7	1.3e-08	0.15	0.06	0.21	TRUE
3	GTEx	Adipose Subcutaneous	ZCCHC8	0.04	0.00	lasso	7	0.00	1.4e-01	5.7	5.4	8.2e-08	-0.31	0.17	0.10	TRUE
50	The Cancer Genome Atlas	Thyroid Carcinoma	PSMD9	0.09	0.10	lasso	4	0.10	7.4e-10	-5.3	5.3	1.4e-07	-0.02	0.01	0.99	TRUE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC338799	0.04	0.02	blup	29	0.04	3.5e-05	3.4	-5.2	2.2e-07	-0.03	0.13	0.56	TRUE
7	GTEx	Adipose Visceral Omentum	RP11-380L11.3	0.15	0.03	lasso	5	0.01	1.4e-01	5.8	8.1	5.4e-16	-0.08	0.04	0.78	FALSE
4	GTEx	Adipose Subcutaneous	CCDC92	0.23	0.04	enet	27	0.16	6.9e-13	-4.9	7.8	8.4e-15	-0.09	0.05	0.95	FALSE
33	METSIM	Adipose	ABCB9	0.04	0.03	enet	19	0.03	7.7e-05	-6.1	-7.6	4.0e-14	0.38	0.08	0.65	FALSE
5	GTEx	Adipose Subcutaneous	RP11-380L11.3	0.09	0.03	lasso	3	0.03	1.4e-03	5.5	7.4	1.1e-13	-0.07	0.13	0.84	FALSE
16	GTEx	Colon Transverse	SNRNP35	0.18	0.02	lasso	8	0.04	6.5e-03	-4.6	7.4	1.7e-13	-0.16	0.02	0.71	FALSE
34	METSIM	Adipose	CCDC92	0.10	0.01	bslmm	435	0.06	5.5e-10	-3.4	7.1	1.1e-12	-0.08	0.04	0.96	FALSE
30	GTEx	Thyroid	CCDC92	0.06	0.03	lasso	3	0.02	1.1e-02	5.5	7.0	2.0e-12	-0.08	0.10	0.83	FALSE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	MLXIP	0.06	0.04	lasso	7	0.02	2.7e-02	7.0	7.0	3.6e-12	-0.17	0.02	0.93	FALSE
48	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLXIP	0.18	0.14	lasso	4	0.13	5.1e-04	6.4	6.8	1.1e-11	-0.16	0.02	0.90	FALSE
15	GTEx	Colon Transverse	MLXIP	0.20	0.18	enet	23	0.14	5.8e-07	7.1	6.8	1.3e-11	-0.17	1.00	0.00	FALSE
23	GTEx	Lung	CCDC92	0.14	0.00	enet	10	0.01	1.1e-01	6.2	6.8	1.5e-11	-0.08	0.02	0.91	FALSE
27	GTEx	Nerve Tibial	KNTC1	0.12	0.05	lasso	5	0.05	1.9e-04	-6.3	-6.8	1.5e-11	0.31	0.53	0.03	FALSE
36	METSIM	Adipose	RP11-214K3.24	0.05	0.03	bslmm	444	0.02	2.7e-04	4.8	6.6	5.0e-11	-0.07	0.18	0.70	FALSE
26	GTEx	Nerve Tibial	CCDC92	0.16	0.01	enet	6	0.04	6.7e-04	4.6	6.5	7.9e-11	-0.10	0.10	0.48	FALSE
21	GTEx	Heart Atrial Appendage	RP11-380L11.4	0.18	0.11	lasso	7	0.12	6.5e-06	5.6	6.5	8.8e-11	-0.07	0.14	0.83	FALSE
17	GTEx	Esophagus Mucosa	KDM2B	0.11	0.04	enet	22	0.10	4.1e-07	2.2	6.2	4.4e-10	-0.10	0.92	0.01	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNAH10	0.11	0.03	blup	99	0.05	8.2e-11	5.2	6.2	5.4e-10	-0.05	0.13	0.87	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HIP1R	0.06	0.02	lasso	6	0.04	1.9e-05	-6.1	-6.1	9.7e-10	0.09	0.18	0.02	FALSE
22	GTEx	Heart Left Ventricle	CCDC92	0.26	0.19	lasso	4	0.21	1.9e-11	4.8	6.1	1.3e-09	-0.06	0.32	0.68	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRC43	0.04	0.00	blup	58	0.01	6.9e-02	6.6	-6.0	1.4e-09	0.12	0.02	0.22	FALSE
35	METSIM	Adipose	MORN3	0.06	0.02	lasso	10	0.04	8.7e-07	5.4	6.0	2.5e-09	-0.05	0.95	0.00	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	VPS33A	0.04	0.05	lasso	1	0.04	3.0e-05	6.0	-6.0	2.6e-09	0.13	0.26	0.73	FALSE
37	YFS	Blood	PSMD9	0.04	0.03	bslmm	324	0.05	8.2e-15	-5.4	5.8	6.4e-09	-0.08	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAH10	0.07	0.03	lasso	3	0.05	7.4e-06	5.6	5.8	6.6e-09	-0.06	0.13	0.85	FALSE
14	GTEx	Colon Sigmoid	RP11-380L11.4	0.21	0.12	lasso	3	0.08	1.1e-03	5.5	5.8	8.7e-09	-0.06	0.13	0.66	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF664	0.06	0.05	enet	9	0.05	2.8e-05	5.5	-5.7	1.1e-08	0.08	0.06	0.94	FALSE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRC43	0.06	0.03	enet	6	0.03	8.7e-04	-4.7	-5.7	1.2e-08	0.10	0.13	0.24	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS33A	0.03	0.05	lasso	1	0.05	4.4e-06	5.6	-5.6	2.4e-08	0.13	0.45	0.54	FALSE
19	GTEx	Esophagus Muscularis	RP11-380L11.4	0.27	0.29	lasso	8	0.27	1.0e-16	5.6	5.5	2.9e-08	-0.05	0.15	0.85	FALSE
24	GTEx	Lung	RP11-380L11.4	0.07	0.07	lasso	3	0.07	8.2e-06	5.6	5.5	4.6e-08	-0.06	0.17	0.82	FALSE
8	GTEx	Artery Tibial	PITPNM2	0.11	0.05	lasso	4	0.04	2.7e-04	-4.9	5.5	4.7e-08	0.00	0.70	0.02	FALSE
20	GTEx	Heart Atrial Appendage	CCDC92	0.12	0.11	enet	9	0.11	1.1e-05	4.5	5.5	4.8e-08	-0.05	0.26	0.63	FALSE
9	GTEx	Artery Tibial	RP11-380L11.4	0.14	0.12	lasso	4	0.12	2.2e-09	5.5	5.4	7.3e-08	-0.04	0.18	0.82	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TMEM120B	0.11	0.04	lasso	3	0.08	1.9e-09	4.3	5.4	7.8e-08	-0.03	1.00	0.00	FALSE
31	GTEx	Thyroid	ZNF664	0.13	0.06	lasso	11	0.08	6.7e-07	4.5	-5.3	8.7e-08	0.04	0.22	0.78	FALSE
11	GTEx	Breast Mammary Tissue (Male)	CCDC92	0.06	-0.01	lasso	3	0.00	4.3e-01	4.7	5.3	9.1e-08	-0.07	0.04	0.11	FALSE
32	GTEx	Whole Blood	DDX55	0.13	0.04	enet	13	0.06	3.3e-06	-3.5	5.2	1.6e-07	-0.17	0.34	0.03	FALSE
28	GTEx	Prostate	CCDC92	0.31	0.10	enet	42	0.11	9.0e-04	4.5	5.2	2.0e-07	-0.08	0.13	0.42	FALSE
29	GTEx	Skin Sun Exposed Lower leg	WDR66	0.19	0.10	lasso	5	0.08	5.5e-07	3.4	5.2	2.1e-07	-0.11	0.99	0.00	FALSE