[Hub]/) : Traits : Leg predicted mass (left) :

chr8:8,092,025-12,973,575

Best TWAS P=4.34e-12 · Best GWAS P=1.87e-11 conditioned to 0.59

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAM167A 0.09 0.09 lasso 6 0.13 1.4e-15 -4.5 -5.5 4.5e-08 -0.59 0.92 0.08 FALSE
2 CommonMind Brain Pre-frontal Cortex FAM86B1 0.02 0.02 lasso 3 0.01 1.3e-02 5.6 6.2 4.8e-10 0.59 0.01 0.97 FALSE
3 CommonMind Brain Pre-frontal Cortex FAM90A25P 0.11 0.08 lasso 3 0.08 1.4e-09 5.7 6.0 2.3e-09 0.54 0.00 1.00 FALSE
4 GTEx Adipose Subcutaneous FDFT1 0.06 0.04 lasso 3 0.04 3.4e-04 -5.0 5.4 6.3e-08 0.45 0.35 0.57 FALSE
5 GTEx Adipose Subcutaneous AF131215.2 0.24 0.15 lasso 7 0.14 3.5e-11 -5.6 5.9 3.3e-09 0.59 0.22 0.78 FALSE
6 GTEx Adipose Subcutaneous AF131215.9 0.20 0.12 enet 60 0.17 1.1e-13 -5.6 5.4 5.3e-08 0.47 0.06 0.94 FALSE
7 GTEx Adipose Visceral Omentum AF131215.2 0.12 0.08 lasso 6 0.06 4.6e-04 6.1 6.2 4.2e-10 0.61 0.07 0.92 FALSE
8 GTEx Adipose Visceral Omentum AF131215.9 0.18 0.16 lasso 7 0.16 2.0e-08 6.1 6.3 4.0e-10 0.61 0.03 0.97 FALSE
9 GTEx Adrenal Gland FAM86B3P 0.16 0.00 enet 18 0.03 2.2e-02 5.0 -5.5 3.1e-08 -0.43 0.06 0.25 FALSE
10 GTEx Adrenal Gland AF131215.2 0.20 0.16 enet 12 0.13 2.2e-05 5.9 6.2 5.7e-10 0.61 0.03 0.97 FALSE
11 GTEx Adrenal Gland AF131215.9 0.18 0.16 lasso 10 0.18 3.5e-07 5.9 6.2 4.3e-10 0.62 0.03 0.97 FALSE
12 GTEx Artery Aorta FDFT1 0.09 0.02 lasso 4 0.03 6.1e-03 4.1 5.5 4.7e-08 0.54 0.14 0.49 FALSE
13 GTEx Artery Aorta ERI1 0.11 0.08 lasso 5 0.10 5.1e-06 6.7 -6.3 3.3e-10 -0.92 0.00 1.00 FALSE
14 GTEx Artery Aorta AF131215.2 0.09 0.09 lasso 7 0.08 2.0e-05 -5.6 6.2 6.2e-10 0.62 0.06 0.93 FALSE
15 GTEx Artery Aorta FAM85A 0.11 0.06 enet 19 0.06 3.4e-04 -4.5 5.4 7.6e-08 0.54 0.14 0.79 FALSE
16 GTEx Artery Aorta AF131215.9 0.13 0.05 lasso 6 0.07 1.3e-04 5.8 6.3 3.7e-10 0.61 0.06 0.94 FALSE
17 GTEx Artery Tibial ERI1 0.05 0.02 lasso 7 0.01 3.2e-02 4.4 -5.7 1.5e-08 -0.82 0.02 0.95 FALSE
18 GTEx Artery Tibial AF131215.2 0.07 0.03 enet 24 0.05 1.8e-04 -6.0 5.7 1.2e-08 0.55 0.07 0.92 FALSE
19 GTEx Artery Tibial FAM85A 0.09 0.06 enet 18 0.08 1.5e-06 -4.6 5.2 2.5e-07 0.48 0.11 0.86 FALSE
20 GTEx Artery Tibial AF131215.9 0.08 0.01 lasso 10 0.02 1.8e-02 -3.5 5.3 1.4e-07 0.52 0.08 0.87 FALSE
21 GTEx Brain Cerebellar Hemisphere FAM86B3P 0.28 0.27 lasso 8 0.28 5.4e-08 5.1 -5.4 6.7e-08 -0.65 0.02 0.98 FALSE
22 GTEx Brain Cerebellar Hemisphere AF131215.2 0.15 0.17 lasso 3 0.09 3.0e-03 -6.0 6.1 1.2e-09 0.56 0.07 0.76 FALSE
23 GTEx Brain Cerebellum FAM86B3P 0.19 0.14 lasso 5 0.16 1.8e-05 4.8 -5.4 6.9e-08 -0.65 0.05 0.94 FALSE
24 GTEx Brain Cortex FAM86B3P 0.14 0.05 enet 9 0.07 5.1e-03 5.0 -5.6 1.7e-08 -0.62 0.06 0.74 FALSE
25 GTEx Brain Frontal Cortex BA9 FAM86B3P 0.16 0.13 enet 27 0.10 1.1e-03 5.3 -5.5 3.2e-08 -0.59 0.06 0.86 FALSE
26 GTEx Breast Mammary Tissue AF131215.2 0.16 0.15 lasso 6 0.12 1.1e-06 -5.6 5.7 9.0e-09 0.64 0.24 0.74 FALSE
27 GTEx Breast Mammary Tissue FAM85A 0.14 0.04 enet 14 0.08 4.4e-05 -4.6 5.2 2.0e-07 0.47 0.11 0.85 FALSE
28 GTEx Breast Mammary Tissue AF131215.9 0.10 0.10 lasso 8 0.12 8.7e-07 -4.4 5.7 1.6e-08 0.64 0.14 0.85 FALSE
29 GTEx Breast Mammary Tissue (Male) FAM85A 0.14 0.03 enet 16 0.09 4.3e-03 -4.6 5.2 2.4e-07 0.46 0.06 0.52 FALSE
30 GTEx Breast Mammary Tissue (Female) AF131215.9 0.04 -0.01 enet 6 0.02 7.3e-02 -4.4 5.7 1.2e-08 0.62 0.08 0.19 FALSE
31 GTEx Cells EBV-transformed lymphocytes AF131215.2 0.20 0.10 enet 14 0.11 1.5e-04 -6.0 5.9 4.0e-09 0.61 0.12 0.86 FALSE
32 GTEx Cells EBV-transformed lymphocytes AF131215.9 0.20 0.15 enet 19 0.13 5.6e-05 -6.0 5.7 1.5e-08 0.59 0.10 0.86 FALSE
33 GTEx Cells Transformed fibroblasts ERI1 0.34 0.35 lasso 7 0.35 1.9e-27 6.7 -6.8 9.6e-12 -0.97 0.00 1.00 FALSE
34 GTEx Colon Sigmoid AF131215.2 0.10 0.00 enet 7 0.02 5.0e-02 6.0 6.0 1.8e-09 0.64 0.10 0.60 FALSE
35 GTEx Colon Sigmoid AF131215.9 0.11 0.17 enet 5 0.09 4.9e-04 -6.0 6.1 1.3e-09 0.56 0.07 0.83 FALSE
36 GTEx Colon Transverse AF131215.2 0.15 0.09 enet 32 0.07 3.1e-04 5.8 5.2 1.7e-07 0.50 0.10 0.88 FALSE
37 GTEx Colon Transverse AF131215.9 0.12 0.14 enet 18 0.12 4.0e-06 -6.0 6.2 7.1e-10 0.55 0.06 0.93 FALSE
38 GTEx Esophagus Gastroesophageal Junction AF131215.2 0.13 0.06 enet 10 0.11 6.4e-05 4.7 5.6 2.3e-08 0.61 0.10 0.84 FALSE
39 GTEx Esophagus Mucosa AF131215.2 0.15 0.14 enet 15 0.18 4.3e-12 -5.3 6.1 1.3e-09 0.62 0.42 0.58 FALSE
40 GTEx Esophagus Mucosa AF131215.9 0.18 0.16 lasso 14 0.19 1.6e-12 5.8 6.4 2.1e-10 0.63 0.04 0.96 FALSE
41 GTEx Esophagus Muscularis ERI1 0.12 0.09 enet 13 0.08 7.7e-06 5.7 -6.0 1.5e-09 -0.86 0.07 0.93 FALSE
42 GTEx Esophagus Muscularis AF131215.2 0.10 0.08 lasso 5 0.09 2.3e-06 -5.3 5.5 3.6e-08 0.57 0.49 0.49 FALSE
43 GTEx Esophagus Muscularis FAM85A 0.10 0.01 enet 20 0.04 2.7e-03 -4.6 5.5 3.3e-08 0.46 0.05 0.89 FALSE
44 GTEx Esophagus Muscularis AF131215.9 0.14 0.17 enet 16 0.17 1.6e-10 -6.0 6.9 4.3e-12 0.60 0.07 0.93 TRUE
45 GTEx Heart Atrial Appendage AF131215.2 0.39 0.13 enet 26 0.21 6.6e-10 -5.3 5.7 1.5e-08 0.59 0.41 0.59 FALSE
46 GTEx Heart Left Ventricle AF131215.2 0.05 0.01 enet 11 0.01 1.5e-01 6.1 6.4 1.2e-10 0.61 0.05 0.89 FALSE
47 GTEx Heart Left Ventricle AF131215.9 0.07 0.10 enet 8 0.10 9.4e-06 -6.0 6.5 8.4e-11 0.59 0.06 0.93 FALSE
48 GTEx Lung AF131215.2 0.12 0.08 lasso 5 0.08 1.0e-06 -6.0 6.2 7.1e-10 0.53 0.07 0.93 FALSE
49 GTEx Lung AF131215.9 0.15 0.18 lasso 4 0.15 1.5e-11 -6.0 6.1 1.4e-09 0.52 0.07 0.93 FALSE
50 GTEx Muscle Skeletal MFHAS1 0.07 0.04 lasso 4 0.04 1.4e-04 4.8 5.3 1.1e-07 0.81 0.16 0.82 FALSE
51 GTEx Nerve Tibial AF131215.2 0.19 0.18 lasso 12 0.23 3.5e-16 -5.3 6.2 5.0e-10 0.60 0.17 0.83 FALSE
52 GTEx Nerve Tibial AF131215.9 0.17 0.17 lasso 4 0.18 5.0e-13 -6.0 5.9 3.3e-09 0.53 0.08 0.92 FALSE
53 GTEx Pancreas AF131215.2 0.16 0.16 enet 17 0.15 9.1e-07 -6.0 6.4 1.3e-10 0.62 0.05 0.94 FALSE
54 GTEx Pancreas AF131215.9 0.25 0.24 enet 14 0.22 1.0e-09 5.8 6.4 2.0e-10 0.60 0.04 0.96 FALSE
55 GTEx Pituitary FAM86B3P 0.13 0.15 lasso 4 0.13 3.5e-04 -4.8 -5.3 9.2e-08 -0.54 0.05 0.84 FALSE
56 GTEx Prostate SOX7 0.48 0.01 enet 14 0.15 1.3e-04 -3.0 5.5 3.7e-08 0.37 0.12 0.09 FALSE
57 GTEx Prostate AF131215.2 0.18 0.02 lasso 6 0.02 9.6e-02 3.9 6.0 1.8e-09 0.57 0.08 0.50 FALSE
58 GTEx Skin Not Sun Exposed Suprapubic AF131215.2 0.16 0.11 enet 21 0.20 3.9e-11 -5.3 5.9 3.5e-09 0.61 0.07 0.93 FALSE
59 GTEx Skin Not Sun Exposed Suprapubic AF131215.9 0.17 0.14 lasso 8 0.19 9.4e-11 -6.0 6.2 7.1e-10 0.59 0.08 0.92 FALSE
60 GTEx Skin Sun Exposed Lower leg AF131215.2 0.14 0.11 lasso 9 0.16 4.3e-13 -5.3 6.0 1.7e-09 0.58 0.30 0.70 FALSE
61 GTEx Skin Sun Exposed Lower leg FAM85A 0.09 0.04 enet 28 0.04 1.4e-04 -4.6 5.7 1.0e-08 0.44 0.08 0.85 FALSE
62 GTEx Skin Sun Exposed Lower leg AF131215.9 0.19 0.17 enet 29 0.21 3.9e-17 -6.0 6.7 2.3e-11 0.61 0.11 0.89 FALSE
63 GTEx Small Intestine Terminal Ileum AF131215.2 0.14 0.07 lasso 3 0.07 1.1e-02 -4.1 5.3 1.4e-07 0.54 0.08 0.66 FALSE
64 GTEx Spleen AF131215.2 0.16 0.08 enet 14 0.06 1.1e-02 -6.0 5.9 3.7e-09 0.60 0.05 0.89 FALSE
65 GTEx Spleen AF131215.9 0.34 0.23 enet 16 0.15 1.2e-04 6.4 5.7 9.9e-09 0.56 0.02 0.97 FALSE
66 GTEx Stomach AF131215.9 0.14 0.06 enet 19 0.06 6.7e-04 -6.0 5.7 1.5e-08 0.53 0.04 0.95 FALSE
67 GTEx Testis FAM86B3P 0.15 0.14 lasso 7 0.13 2.2e-06 5.0 -5.5 4.3e-08 -0.61 0.03 0.96 FALSE
68 GTEx Testis AF131215.2 0.28 0.18 enet 41 0.17 8.0e-08 -5.3 6.4 1.3e-10 0.47 0.57 0.43 FALSE
69 GTEx Testis AF131215.9 0.12 0.21 lasso 4 0.14 5.6e-07 -5.3 5.3 1.2e-07 0.52 0.29 0.71 FALSE
70 GTEx Thyroid SGK223 0.19 0.35 enet 16 0.36 1.1e-28 5.2 -5.8 6.1e-09 -0.69 0.04 0.96 FALSE
71 GTEx Thyroid AF131215.2 0.11 0.15 enet 17 0.18 1.2e-13 -5.3 6.5 9.6e-11 0.60 0.17 0.83 FALSE
72 GTEx Thyroid AF131215.9 0.11 0.08 enet 16 0.17 4.7e-13 -6.0 5.9 3.2e-09 0.59 0.08 0.92 FALSE
73 GTEx Uterus AF131215.2 0.17 0.07 enet 13 0.09 7.1e-03 5.9 6.1 9.1e-10 0.62 0.06 0.78 FALSE
74 GTEx Vagina AF131215.9 0.21 0.11 lasso 9 0.08 6.3e-03 6.0 6.3 3.6e-10 0.57 0.05 0.91 FALSE
75 NTR Blood MSRA 0.02 0.01 blup 833 0.01 2.3e-05 4.4 -6.6 4.3e-11 -0.58 0.08 0.91 FALSE
76 ROSMAP Brain Pre-frontal Cortex FAM167A 0.12 0.03 bslmm 620 0.08 1.3e-10 2.0 -5.6 2.3e-08 -0.55 0.39 0.60 FALSE
77 ROSMAP Brain Pre-frontal Cortex XKR6 0.11 0.10 enet 23 0.13 1.2e-16 -5.0 6.6 3.6e-11 0.63 0.19 0.81 FALSE
78 ROSMAP Brain Pre-frontal Cortex FAM86B3P 0.19 0.27 bslmm 331 0.27 5.6e-35 5.0 -5.2 2.3e-07 -0.50 0.11 0.88 FALSE
79 ROSMAP Brain Pre-frontal Cortex FAM66A 0.23 0.26 enet 29 0.30 4.7e-39 5.9 5.7 1.4e-08 0.53 0.00 1.00 FALSE
80 ROSMAP Brain Pre-frontal Cortex FAM85B 0.16 0.23 enet 18 0.22 1.8e-28 4.7 -5.2 2.5e-07 -0.63 0.31 0.68 FALSE
81 ROSMAP Brain Pre-frontal Cortex AF131215.3 0.08 0.10 lasso 7 0.12 8.3e-16 5.8 6.4 1.5e-10 0.64 0.02 0.98 FALSE
82 ROSMAP Brain Pre-frontal Cortex RP11-481A20.11 0.06 0.04 blup 286 0.04 2.2e-06 5.7 6.3 2.5e-10 0.60 0.02 0.98 FALSE
83 ROSMAP Brain Pre-frontal Cortex AF131215.2 0.49 0.57 lasso 7 0.57 9.0e-89 -6.0 6.1 1.1e-09 0.53 0.06 0.94 FALSE
84 ROSMAP Brain Pre-frontal Cortex FAM85A 0.11 0.07 enet 23 0.11 4.3e-14 5.9 5.6 2.2e-08 0.56 0.00 1.00 FALSE
85 The Cancer Genome Atlas Bladder Urothelial Carcinoma ERI1 0.05 0.01 blup 72 0.01 5.0e-02 6.7 -6.9 5.1e-12 -0.84 0.00 0.90 TRUE
86 The Cancer Genome Atlas Breast Invasive Carcinoma RP1L1 0.02 0.01 lasso 2 0.01 4.1e-03 5.6 5.8 5.1e-09 0.49 0.01 0.85 FALSE
87 The Cancer Genome Atlas Breast Invasive Carcinoma TDH 0.03 0.04 lasso 4 0.03 1.2e-07 -5.5 -5.4 8.6e-08 -0.45 0.00 1.00 FALSE
88 The Cancer Genome Atlas Breast Invasive Carcinoma TNKS 0.02 0.00 blup 130 0.01 2.1e-02 4.1 5.5 4.5e-08 0.36 0.02 0.20 FALSE
89 The Cancer Genome Atlas Esophageal Carcinoma FLJ10661 0.20 0.23 lasso 2 0.23 5.6e-08 5.3 5.2 1.9e-07 0.60 0.01 0.99 FALSE
90 The Cancer Genome Atlas Brain Lower Grade Glioma FLJ10661 0.21 0.26 lasso 9 0.30 2.3e-34 4.8 -5.5 3.7e-08 -0.60 0.04 0.95 FALSE
91 The Cancer Genome Atlas Lung Adenocarcinoma ERI1 0.06 0.04 blup 72 0.04 1.5e-05 5.4 -6.0 2.0e-09 -0.89 0.04 0.96 FALSE
92 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FLJ10661 0.25 0.18 lasso 4 0.16 4.2e-07 5.3 -5.4 7.7e-08 -0.60 0.00 0.99 FALSE
93 The Cancer Genome Atlas Testicular Germ Cell Tumors ZNF705D 0.23 0.20 lasso 3 0.24 4.7e-09 5.9 -5.5 5.0e-08 -0.51 0.00 1.00 FALSE
94 The Cancer Genome Atlas Thyroid Carcinoma SGK223 0.16 0.20 enet 14 0.22 6.1e-21 -4.5 -5.2 2.2e-07 -0.60 0.16 0.81 FALSE