Best TWAS P=2.17e-16 · Best GWAS P=1.16e-14 conditioned to 0.574
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | B3GNT7 | 0.30 | 0.20 | lasso | 6 | 0.16 | 3.2e-09 | -5.0 | 5.2 | 2.4e-07 | -0.01 | 1.00 | 0.00 | TRUE |
2 | GTEx | Artery Coronary | RP11-690I21.1 | 0.24 | -0.01 | lasso | 8 | -0.01 | 6.8e-01 | -5.8 | 6.0 | 2.2e-09 | -0.60 | 0.07 | 0.14 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | PTMA | 0.28 | 0.12 | enet | 19 | 0.06 | 1.5e-02 | -5.8 | 6.4 | 1.3e-10 | -0.48 | 0.05 | 0.51 | FALSE |
4 | GTEx | Brain Frontal Cortex BA9 | C2orf82 | 0.24 | 0.16 | lasso | 10 | 0.12 | 3.9e-04 | -4.9 | 5.7 | 1.5e-08 | 0.02 | 0.04 | 0.93 | FALSE |
5 | GTEx | Brain Putamen basal ganglia | C2orf82 | 0.28 | 0.22 | lasso | 3 | 0.18 | 5.3e-05 | -5.0 | 5.8 | 5.2e-09 | 0.01 | 0.04 | 0.78 | FALSE |
6 | GTEx | Heart Atrial Appendage | COPS7B | 0.22 | 0.01 | lasso | 6 | 0.01 | 1.3e-01 | -5.8 | -6.5 | 1.0e-10 | 0.66 | 0.05 | 0.20 | FALSE |
7 | GTEx | Liver | PDE6D | 0.21 | 0.10 | lasso | 4 | 0.09 | 1.8e-03 | -7.7 | -8.2 | 2.2e-16 | 0.81 | 0.01 | 0.90 | TRUE |
8 | GTEx | Prostate | B3GNT7 | 0.34 | 0.15 | lasso | 3 | 0.08 | 4.4e-03 | -5.1 | 5.1 | 2.7e-07 | -0.01 | 0.24 | 0.12 | FALSE |
9 | GTEx | Thyroid | GIGYF2 | 0.08 | 0.02 | lasso | 3 | 0.01 | 6.7e-02 | -6.2 | -5.7 | 1.4e-08 | -0.02 | 0.11 | 0.07 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | NCL | 0.16 | 0.05 | lasso | 6 | 0.08 | 6.1e-10 | 4.3 | 7.0 | 2.8e-12 | 0.06 | 0.01 | 0.99 | TRUE |
11 | ROSMAP | Brain Pre-frontal Cortex | LINC00471 | 0.34 | 0.26 | lasso | 10 | 0.36 | 2.1e-48 | -6.3 | 5.6 | 2.2e-08 | -0.04 | 0.82 | 0.18 | FALSE |
12 | YFS | Blood | EIF4E2 | 0.06 | 0.04 | enet | 27 | 0.04 | 2.8e-13 | 4.5 | 5.2 | 1.7e-07 | -0.04 | 1.00 | 0.00 | FALSE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C2orf52 | 0.15 | 0.14 | enet | 8 | 0.13 | 3.7e-11 | -6.4 | 6.5 | 1.1e-10 | -0.02 | 0.71 | 0.29 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C2orf52 | 0.19 | 0.22 | blup | 42 | 0.25 | 4.1e-50 | -6.3 | 5.5 | 3.7e-08 | -0.02 | 0.58 | 0.42 | FALSE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DIS3L2 | 0.05 | 0.02 | enet | 10 | 0.02 | 3.8e-05 | -3.6 | -6.2 | 6.3e-10 | 0.15 | 0.10 | 0.02 | TRUE |
16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C2orf52 | 0.28 | 0.12 | lasso | 6 | 0.12 | 2.0e-06 | -6.8 | 7.0 | 1.9e-12 | -0.04 | 0.06 | 0.94 | FALSE |
17 | The Cancer Genome Atlas | Colon Adenocarcinoma | C2orf52 | 0.21 | 0.16 | blup | 42 | 0.24 | 7.1e-14 | -6.3 | 6.6 | 4.7e-11 | 0.00 | 0.51 | 0.49 | FALSE |
18 | The Cancer Genome Atlas | Esophageal Carcinoma | C2orf52 | 0.16 | 0.03 | enet | 6 | 0.10 | 3.3e-04 | -3.1 | 5.4 | 5.9e-08 | 0.02 | 0.05 | 0.47 | FALSE |
19 | The Cancer Genome Atlas | Glioblastoma Multiforme | C2orf52 | 0.28 | 0.12 | enet | 12 | 0.18 | 5.0e-06 | -6.6 | 6.8 | 1.2e-11 | -0.03 | 0.04 | 0.85 | FALSE |
20 | The Cancer Genome Atlas | Glioblastoma Multiforme | C2orf82 | 0.20 | 0.24 | lasso | 8 | 0.20 | 9.1e-07 | -4.9 | 5.2 | 1.9e-07 | 0.03 | 0.06 | 0.92 | FALSE |
21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C2orf52 | 0.18 | 0.16 | blup | 42 | 0.17 | 9.8e-19 | -6.4 | 5.4 | 5.2e-08 | 0.01 | 0.68 | 0.32 | FALSE |
22 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C2orf52 | 0.23 | 0.25 | enet | 12 | 0.28 | 2.9e-32 | -6.4 | 6.1 | 1.1e-09 | -0.03 | 0.80 | 0.20 | FALSE |
23 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C2orf52 | 0.18 | 0.20 | lasso | 3 | 0.19 | 3.4e-11 | -6.3 | 6.3 | 2.6e-10 | -0.02 | 0.60 | 0.40 | FALSE |
24 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EFHD1 | 0.11 | 0.01 | blup | 70 | 0.03 | 1.0e-02 | 5.6 | 8.0 | 9.1e-16 | -0.03 | 0.02 | 0.70 | TRUE |
25 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | KCNJ13 | 0.07 | 0.06 | enet | 13 | 0.05 | 4.7e-04 | -6.8 | 6.0 | 2.7e-09 | 0.01 | 0.02 | 0.91 | FALSE |
26 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C2orf52 | 0.32 | 0.25 | blup | 42 | 0.31 | 1.5e-35 | -6.4 | 5.2 | 1.8e-07 | -0.03 | 0.76 | 0.24 | FALSE |
27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C2orf82 | 0.14 | 0.20 | enet | 6 | 0.19 | 3.1e-21 | -5.0 | 5.2 | 1.5e-07 | 0.01 | 1.00 | 0.00 | FALSE |
28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIGYF2 | 0.02 | 0.01 | lasso | 3 | 0.01 | 5.3e-02 | -6.8 | -6.9 | 4.5e-12 | -0.02 | 0.03 | 0.88 | FALSE |
29 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NGEF | 0.03 | 0.01 | blup | 130 | 0.01 | 2.0e-02 | -6.7 | 5.7 | 9.7e-09 | 0.01 | 0.02 | 0.90 | FALSE |
30 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C2orf52 | 0.13 | 0.06 | lasso | 4 | 0.05 | 2.1e-03 | -6.4 | 6.4 | 1.8e-10 | -0.03 | 0.06 | 0.11 | FALSE |
31 | The Cancer Genome Atlas | Lung Adenocarcinoma | C2orf52 | 0.18 | 0.16 | enet | 12 | 0.19 | 3.0e-21 | -6.4 | 5.7 | 1.1e-08 | -0.03 | 0.63 | 0.37 | FALSE |
32 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNG | 0.04 | 0.00 | blup | 58 | 0.00 | 1.3e-01 | 2.4 | -5.3 | 1.1e-07 | 0.12 | 0.01 | 0.29 | FALSE |
33 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C2orf52 | 0.28 | 0.18 | lasso | 4 | 0.20 | 3.7e-22 | -6.8 | 6.5 | 1.1e-10 | -0.05 | 0.24 | 0.76 | FALSE |
34 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C2orf52 | 0.24 | 0.20 | lasso | 3 | 0.20 | 1.4e-13 | -6.3 | 6.3 | 3.4e-10 | -0.02 | 0.70 | 0.30 | FALSE |
35 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C2orf52 | 0.32 | 0.21 | lasso | 7 | 0.21 | 3.6e-09 | -6.2 | 6.1 | 1.0e-09 | -0.06 | 0.48 | 0.52 | FALSE |
36 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | KCNJ13 | 0.07 | 0.07 | blup | 36 | 0.06 | 2.4e-03 | -6.8 | 6.6 | 5.4e-11 | 0.02 | 0.01 | 0.88 | FALSE |
37 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C2orf52 | 0.27 | 0.27 | lasso | 5 | 0.28 | 1.7e-11 | -6.4 | 6.6 | 4.1e-11 | -0.01 | 0.46 | 0.54 | FALSE |
38 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C2orf52 | 0.32 | 0.34 | blup | 42 | 0.39 | 9.3e-44 | -6.3 | 5.9 | 3.4e-09 | 0.00 | 0.38 | 0.62 | FALSE |
39 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GIGYF2 | 0.04 | 0.00 | blup | 103 | 0.02 | 2.1e-03 | -5.0 | -6.5 | 9.5e-11 | 0.01 | 0.04 | 0.81 | FALSE |
40 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C2orf52 | 0.21 | 0.20 | lasso | 1 | 0.18 | 1.4e-05 | -6.8 | 6.8 | 1.1e-11 | -0.02 | 0.04 | 0.51 | FALSE |
41 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C2orf52 | 0.12 | 0.10 | enet | 11 | 0.12 | 5.6e-09 | -6.3 | 6.2 | 6.7e-10 | 0.00 | 0.41 | 0.59 | FALSE |
42 | The Cancer Genome Atlas | Stomach Adenocarcinoma | KCNJ13 | 0.09 | 0.06 | blup | 36 | 0.08 | 3.8e-06 | -6.8 | 5.8 | 6.7e-09 | 0.02 | 0.01 | 0.98 | FALSE |
43 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2orf52 | 0.29 | 0.17 | enet | 10 | 0.19 | 3.2e-07 | -6.4 | 6.3 | 2.7e-10 | -0.04 | 0.34 | 0.49 | FALSE |
44 | The Cancer Genome Atlas | Thyroid Carcinoma | C2orf52 | 0.45 | 0.31 | enet | 10 | 0.35 | 4.9e-35 | -6.2 | 5.5 | 3.0e-08 | -0.01 | 0.86 | 0.14 | FALSE |
45 | The Cancer Genome Atlas | Thyroid Carcinoma | KCNJ13 | 0.03 | 0.00 | blup | 35 | 0.01 | 4.3e-02 | 5.6 | -7.4 | 1.6e-13 | -0.02 | 0.01 | 0.56 | FALSE |
46 | The Cancer Genome Atlas | Thyroid Carcinoma | NGEF | 0.04 | 0.03 | enet | 7 | 0.03 | 5.6e-04 | 5.7 | -6.9 | 5.8e-12 | 0.00 | 0.04 | 0.93 | FALSE |