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chr15:39,530,508-43,198,430

Best TWAS P=3.72e-14 · Best GWAS P=8.87e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Brain Cerebellum	RP11-23P13.4	0.19	0.05	enet	13	0.10	7.6e-04	6.8	-7.6	3.7e-14	-0.89	0.02	0.88	TRUE
50	GTEx	Skin Sun Exposed Lower leg	CHP1	0.06	0.04	enet	9	0.04	3.1e-04	6.6	-7.1	1.4e-12	-0.20	0.10	0.81	TRUE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JMJD7-PLA2G4B	0.04	0.02	lasso	3	0.02	1.9e-03	6.8	6.8	9.9e-12	0.98	0.01	0.94	TRUE
71	The Cancer Genome Atlas	Esophageal Carcinoma	EIF2AK4	0.16	0.07	lasso	6	0.13	7.2e-05	-6.2	-6.2	4.5e-10	-0.02	0.00	0.93	TRUE
61	NTR	Blood	INO80	0.02	0.02	enet	8	0.03	2.8e-09	6.1	-6.2	7.1e-10	-0.01	0.12	0.88	TRUE
1	CommonMind	Brain Pre-frontal Cortex	EXD1	0.04	0.04	lasso	3	0.04	8.1e-06	6.1	-6.1	9.0e-10	-0.03	0.12	0.88	TRUE
70	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RPAP1	0.04	0.00	blup	56	0.03	1.4e-02	5.1	-5.8	6.4e-09	-0.51	0.02	0.36	TRUE
17	GTEx	Brain Cerebellum	EHD4	0.36	0.31	lasso	2	0.29	4.3e-09	-4.6	-5.5	4.8e-08	-0.54	0.60	0.36	TRUE
56	GTEx	Thyroid	PLA2G4B	0.14	0.09	enet	11	0.08	1.6e-06	7.1	7.4	1.6e-13	0.92	0.01	0.99	FALSE
18	GTEx	Brain Cerebellum	MAPKBP1	0.23	0.09	lasso	8	0.12	2.2e-04	6.8	-7.3	2.3e-13	-0.92	0.02	0.96	FALSE
63	YFS	Blood	MGA	0.01	0.00	blup	454	0.00	7.1e-02	5.3	7.3	2.6e-13	0.39	0.12	0.09	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MAPKBP1	0.10	0.06	enet	15	0.10	9.6e-13	6.6	-7.3	3.0e-13	-0.81	0.03	0.97	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	JMJD7-PLA2G4B	0.07	0.02	enet	7	0.03	3.2e-04	6.8	7.3	3.3e-13	0.83	0.00	0.96	FALSE
10	GTEx	Artery Aorta	PLA2G4B	0.10	0.02	lasso	3	0.02	3.9e-02	7.0	7.2	4.4e-13	0.97	0.02	0.85	FALSE
21	GTEx	Brain Cortex	MAPKBP1	0.29	0.00	enet	21	0.04	2.7e-02	-6.2	-7.0	2.9e-12	-0.82	0.07	0.68	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	PLA2G4B	0.17	0.18	lasso	5	0.18	2.9e-10	6.8	7.0	3.4e-12	0.99	0.01	0.99	FALSE
51	GTEx	Skin Sun Exposed Lower leg	PLA2G4B	0.16	0.18	lasso	3	0.17	2.5e-14	6.8	6.8	8.9e-12	0.99	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	JMJD7-PLA2G4B	0.04	0.00	enet	8	0.01	2.8e-02	7.0	6.8	8.9e-12	0.90	0.00	0.91	FALSE
64	YFS	Blood	PLA2G4B	0.07	0.11	bslmm	409	0.12	1.6e-35	6.6	6.6	3.6e-11	0.93	0.04	0.96	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHP	0.01	0.01	blup	54	0.01	1.4e-02	6.4	-6.6	4.2e-11	-0.07	0.01	0.89	FALSE
59	METSIM	Adipose	JMJD7	0.16	0.20	lasso	11	0.22	5.6e-32	-6.2	6.5	9.0e-11	0.78	0.72	0.28	FALSE
39	GTEx	Lung	OIP5-AS1	0.09	0.08	enet	14	0.12	2.8e-09	6.6	6.5	1.0e-10	0.10	0.15	0.85	FALSE
40	GTEx	Nerve Tibial	MAPKBP1	0.09	0.05	lasso	3	0.08	3.5e-06	7.0	-6.5	1.0e-10	-0.91	0.01	0.99	FALSE
14	GTEx	Artery Tibial	MAPKBP1	0.07	0.01	lasso	6	0.00	4.3e-01	-6.0	-6.5	1.1e-10	-0.73	0.04	0.92	FALSE
24	GTEx	Brain Cortex	GCHFR	0.25	0.04	enet	15	0.05	1.4e-02	6.3	-6.3	2.6e-10	-0.01	0.03	0.77	FALSE
23	GTEx	Brain Cortex	NDUFAF1	0.40	0.37	enet	22	0.36	7.0e-11	5.6	-6.3	3.5e-10	-0.30	0.97	0.03	FALSE
8	GTEx	Adrenal Gland	NDUFAF1	0.13	0.03	lasso	3	0.00	4.8e-01	3.7	-6.2	4.7e-10	-0.53	0.06	0.23	FALSE
9	GTEx	Artery Aorta	MAPKBP1	0.12	0.00	lasso	5	0.00	6.2e-01	3.8	-6.2	4.8e-10	-0.83	0.02	0.85	FALSE
57	GTEx	Thyroid	OIP5-AS1	0.20	0.19	lasso	8	0.20	4.1e-15	6.1	6.2	4.8e-10	0.12	0.60	0.40	FALSE
11	GTEx	Artery Aorta	OIP5-AS1	0.16	0.21	enet	26	0.23	5.2e-13	5.7	6.2	6.7e-10	0.18	0.64	0.36	FALSE
4	CommonMind	Brain Pre-frontal Cortex	NDUFAF1	0.14	0.16	bslmm	304	0.19	6.6e-23	5.6	-6.1	8.7e-10	-0.45	0.96	0.04	FALSE
5	GTEx	Adipose Subcutaneous	PLA2G4B	0.06	0.00	enet	11	0.00	6.9e-01	-5.0	6.1	1.1e-09	0.79	0.02	0.86	FALSE
55	GTEx	Testis	OIP5-AS1	0.14	0.16	lasso	1	0.14	8.6e-07	6.1	6.1	1.2e-09	0.13	0.58	0.30	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INO80	0.07	0.04	blup	40	0.06	1.2e-03	5.1	6.1	1.3e-09	0.02	0.02	0.81	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	INO80	0.03	0.02	blup	39	0.03	1.0e-03	3.6	6.1	1.3e-09	0.04	0.02	0.95	FALSE
28	GTEx	Breast Mammary Tissue (Female)	OIP5-AS1	0.28	0.31	lasso	3	0.29	3.0e-09	6.1	6.0	1.7e-09	0.11	0.61	0.38	FALSE
43	GTEx	Pancreas	EIF2AK4	0.40	0.29	lasso	5	0.29	7.6e-13	-6.2	-6.0	1.7e-09	0.00	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	EIF2AK4	0.05	0.03	lasso	7	0.03	9.5e-07	-6.2	-6.0	1.7e-09	-0.01	0.00	1.00	FALSE
58	GTEx	Vagina	VPS39	0.31	0.14	lasso	2	0.05	2.4e-02	-5.7	-6.0	1.8e-09	-0.66	0.06	0.32	FALSE
41	GTEx	Nerve Tibial	NUSAP1	0.15	0.09	enet	10	0.15	9.8e-11	4.1	6.0	2.1e-09	0.09	0.91	0.08	FALSE
60	METSIM	Adipose	MAPKBP1	0.08	0.03	lasso	10	0.02	1.1e-04	-5.8	-6.0	2.4e-09	-0.63	0.48	0.51	FALSE
2	CommonMind	Brain Pre-frontal Cortex	JMJD7	0.10	0.06	bslmm	419	0.07	2.4e-09	7.0	5.9	3.0e-09	0.85	0.01	0.99	FALSE
27	GTEx	Breast Mammary Tissue	OIP5-AS1	0.20	0.24	lasso	7	0.22	1.8e-11	6.1	5.9	3.6e-09	0.13	0.63	0.37	FALSE
44	GTEx	Pancreas	OIP5-AS1	0.07	0.13	lasso	2	0.10	7.5e-05	6.1	5.9	3.7e-09	0.13	0.49	0.23	FALSE
30	GTEx	Colon Sigmoid	NDUFAF1	0.15	0.06	lasso	4	0.06	5.2e-03	5.1	-5.9	4.6e-09	-0.20	0.37	0.08	FALSE
78	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPAP1	0.37	0.10	blup	56	0.08	5.5e-03	-4.1	-5.8	5.0e-09	-0.54	0.01	0.49	FALSE
36	GTEx	Esophagus Mucosa	CHP1	0.19	0.10	lasso	7	0.09	1.4e-06	5.3	-5.8	5.4e-09	-0.05	0.18	0.82	FALSE
38	GTEx	Lung	SPTBN5	0.23	0.17	enet	27	0.22	1.9e-16	-4.0	5.7	1.3e-08	0.59	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	OIP5-AS1	0.23	0.16	lasso	10	0.11	2.8e-06	4.4	5.7	1.5e-08	0.22	0.89	0.10	FALSE
15	GTEx	Artery Tibial	OIP5-AS1	0.16	0.23	lasso	4	0.24	3.6e-19	6.1	5.7	1.5e-08	0.14	0.64	0.36	FALSE
26	GTEx	Breast Mammary Tissue	EIF2AK4	0.24	0.10	lasso	8	0.06	3.2e-04	-6.2	-5.7	1.6e-08	0.01	0.00	1.00	FALSE
49	GTEx	Skin Sun Exposed Lower leg	EIF2AK4	0.34	0.15	enet	16	0.15	9.4e-13	-6.2	-5.6	1.7e-08	-0.01	0.00	1.00	FALSE
6	GTEx	Adipose Subcutaneous	OIP5-AS1	0.21	0.23	lasso	5	0.26	3.7e-21	6.2	5.6	2.0e-08	0.13	0.64	0.36	FALSE
72	The Cancer Genome Atlas	Glioblastoma Multiforme	SPTBN5	0.21	0.07	blup	78	0.12	2.3e-04	-4.0	5.6	2.0e-08	0.67	0.27	0.25	FALSE
12	GTEx	Artery Aorta	RP11-23P13.4	0.10	0.02	lasso	4	0.02	2.7e-02	3.8	-5.5	3.2e-08	-0.66	0.12	0.41	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NUSAP1	0.03	0.01	blup	40	0.02	3.4e-03	4.5	-5.5	3.3e-08	-0.14	0.03	0.86	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INO80	0.03	0.02	blup	38	0.03	1.1e-02	3.4	5.5	4.0e-08	0.03	0.03	0.48	FALSE
22	GTEx	Brain Cortex	NUSAP1	0.43	0.25	enet	27	0.26	8.7e-08	4.0	5.5	4.3e-08	0.35	0.95	0.03	FALSE
37	GTEx	Esophagus Muscularis	OIP5-AS1	0.24	0.24	enet	19	0.28	4.6e-17	4.9	5.4	5.8e-08	0.11	0.72	0.28	FALSE
29	GTEx	Cells Transformed fibroblasts	CHP1	0.13	0.11	lasso	6	0.11	2.1e-08	4.6	-5.4	6.8e-08	-0.14	0.86	0.14	FALSE
13	GTEx	Artery Tibial	EHD4	0.14	0.03	enet	21	0.06	1.0e-05	3.4	-5.3	9.0e-08	-0.64	0.14	0.83	FALSE
25	GTEx	Brain Frontal Cortex BA9	NDUFAF1	0.55	0.37	lasso	8	0.40	1.6e-11	4.9	-5.3	9.0e-08	-0.14	0.98	0.02	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	EIF2AK4	0.15	0.07	lasso	5	0.09	4.9e-09	-6.2	-5.3	9.6e-08	0.01	0.00	1.00	FALSE
62	YFS	Blood	MAPKBP1	0.06	0.06	lasso	8	0.08	4.7e-25	-5.8	5.3	1.0e-07	0.50	0.94	0.06	FALSE
34	GTEx	Esophagus Mucosa	EIF2AK4	0.30	0.11	lasso	6	0.14	9.4e-10	-4.4	-5.3	1.1e-07	0.01	0.00	1.00	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	OIP5-AS1	0.17	0.19	enet	17	0.22	4.3e-12	4.1	5.3	1.1e-07	0.16	0.98	0.02	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	OIP5-AS1	0.18	0.10	lasso	7	0.11	8.9e-05	4.9	5.3	1.3e-07	0.13	0.63	0.14	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPAP1	0.08	0.10	enet	13	0.13	7.8e-25	-4.2	-5.3	1.3e-07	-0.60	0.94	0.05	FALSE
16	GTEx	Brain Cerebellum	RPAP1	0.16	0.10	lasso	5	0.12	1.6e-04	3.3	-5.3	1.4e-07	-0.63	0.11	0.62	FALSE
19	GTEx	Brain Cerebellum	RP11-23P13.6	0.16	0.14	enet	9	0.11	3.6e-04	-4.6	-5.3	1.4e-07	-0.48	0.21	0.59	FALSE
53	GTEx	Stomach	SPTBN5	0.11	0.03	enet	19	0.01	8.2e-02	-3.7	5.3	1.4e-07	0.55	0.14	0.15	FALSE
52	GTEx	Skin Sun Exposed Lower leg	OIP5-AS1	0.13	0.17	lasso	3	0.23	5.0e-19	5.7	5.2	1.5e-07	0.15	0.71	0.29	FALSE
42	GTEx	Nerve Tibial	OIP5-AS1	0.20	0.22	enet	21	0.26	1.3e-18	4.4	5.2	1.7e-07	0.09	0.81	0.19	FALSE
54	GTEx	Testis	MAPKBP1	0.20	0.02	enet	17	0.04	5.8e-03	-4.0	-5.2	1.8e-07	-0.51	0.16	0.47	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	NDUFAF1	0.16	0.06	lasso	3	0.07	1.7e-04	5.1	-5.2	2.0e-07	-0.21	0.09	0.14	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SPTBN5	0.10	0.09	enet	7	0.08	4.6e-07	-3.7	5.2	2.0e-07	0.68	0.41	0.56	FALSE
32	GTEx	Colon Transverse	OIP5-AS1	0.13	0.14	lasso	5	0.15	1.8e-07	4.9	5.2	2.6e-07	0.13	0.85	0.13	FALSE
45	GTEx	Prostate	OIP5-AS1	0.26	0.03	lasso	9	0.09	2.5e-03	6.1	5.1	2.9e-07	0.10	0.09	0.14	FALSE
35	GTEx	Esophagus Mucosa	NDUFAF1	0.25	0.18	enet	26	0.24	4.3e-16	5.1	-5.1	3.0e-07	-0.20	0.99	0.01	FALSE
31	GTEx	Colon Transverse	EIF2AK4	0.40	0.16	lasso	4	0.15	9.2e-08	-4.4	-5.1	3.1e-07	0.02	0.00	1.00	FALSE