Best TWAS P=7.62e-11 · Best GWAS P=3.87e-15 conditioned to 0.639
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC9A3R2 | 0.15 | 0.09 | enet | 7 | 0.10 | 7.8e-12 | -4.7 | 5.4 | 7.7e-08 | -0.59 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | CCDC78 | 0.21 | 0.12 | enet | 12 | 0.12 | 6.2e-04 | -3.5 | -5.2 | 2.4e-07 | 0.01 | 0.14 | 0.39 | FALSE |
| 3 | GTEx | Brain Putamen basal ganglia | DECR2 | 0.14 | 0.01 | enet | 8 | 0.06 | 1.9e-02 | 5.1 | 5.2 | 2.0e-07 | -0.01 | 0.12 | 0.33 | TRUE |
| 4 | GTEx | Nerve Tibial | PDIA2 | 0.12 | 0.01 | enet | 13 | 0.06 | 4.4e-05 | -5.4 | 5.9 | 4.1e-09 | -0.05 | 0.07 | 0.92 | FALSE |
| 5 | GTEx | Nerve Tibial | ARHGDIG | 0.13 | 0.07 | lasso | 2 | 0.07 | 8.0e-06 | -5.4 | 5.2 | 1.8e-07 | -0.07 | 0.09 | 0.64 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | RAB11FIP3 | 0.15 | 0.06 | lasso | 9 | 0.09 | 1.9e-05 | 4.5 | -5.1 | 3.1e-07 | -0.01 | 0.71 | 0.24 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RNPS1 | 0.10 | 0.01 | lasso | 6 | 0.04 | 6.3e-04 | 4.2 | -5.5 | 3.7e-08 | 0.32 | 0.06 | 0.83 | FALSE |
| 8 | GTEx | Testis | RGS11 | 0.33 | 0.04 | lasso | 10 | 0.08 | 2.8e-04 | -5.4 | -5.4 | 6.7e-08 | 0.05 | 0.13 | 0.11 | FALSE |
| 9 | GTEx | Whole Blood | NME4 | 0.12 | 0.03 | lasso | 5 | 0.04 | 3.0e-04 | 3.5 | 6.1 | 8.8e-10 | -0.07 | 0.05 | 0.92 | FALSE |
| 10 | METSIM | Adipose | PKD1 | 0.06 | 0.02 | bslmm | 370 | 0.03 | 9.5e-06 | -6.8 | 5.5 | 4.7e-08 | -0.78 | 0.00 | 0.99 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | SLC9A3R2 | 0.16 | 0.11 | lasso | 6 | 0.12 | 6.3e-15 | -6.1 | 5.9 | 3.0e-09 | -0.62 | 0.99 | 0.01 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | MLST8 | 0.22 | 0.18 | lasso | 6 | 0.18 | 7.1e-23 | 5.0 | 5.8 | 5.0e-09 | -0.49 | 1.00 | 0.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | PDIA2 | 0.15 | 0.07 | lasso | 8 | 0.10 | 5.2e-13 | -5.4 | -6.5 | 7.6e-11 | 0.04 | 0.10 | 0.90 | TRUE |
| 14 | YFS | Blood | MLST8 | 0.12 | 0.06 | bslmm | 326 | 0.06 | 4.3e-20 | -4.0 | 5.6 | 2.6e-08 | -0.38 | 1.00 | 0.00 | TRUE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AXIN1 | 0.03 | 0.01 | blup | 88 | 0.01 | 7.7e-03 | -5.3 | 5.8 | 5.8e-09 | -0.03 | 0.01 | 0.71 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CASKIN1 | 0.02 | 0.00 | blup | 38 | 0.01 | 4.5e-02 | 4.8 | -6.4 | 2.0e-10 | 0.46 | 0.03 | 0.04 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC100134368 | 0.03 | 0.00 | enet | 5 | 0.01 | 2.8e-02 | -3.1 | -5.8 | 5.1e-09 | 0.03 | 0.01 | 0.62 | FALSE |
| 18 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LOC100134368 | 0.08 | 0.07 | blup | 48 | 0.06 | 1.9e-03 | 3.5 | -6.0 | 2.6e-09 | 0.06 | 0.05 | 0.18 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C16orf79 | 0.05 | 0.01 | lasso | 4 | 0.02 | 1.5e-03 | 4.8 | -5.6 | 2.7e-08 | 0.24 | 0.01 | 0.93 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100134368 | 0.05 | 0.00 | blup | 48 | 0.04 | 2.5e-05 | -4.4 | -5.7 | 1.4e-08 | 0.04 | 0.01 | 0.89 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | CASKIN1 | 0.06 | 0.02 | blup | 38 | 0.04 | 1.5e-04 | -7.8 | -6.4 | 1.7e-10 | 0.81 | 0.00 | 0.97 | TRUE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC100134368 | 0.06 | 0.05 | blup | 47 | 0.07 | 3.9e-07 | 3.5 | -6.1 | 1.1e-09 | 0.05 | 0.19 | 0.75 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | MLST8 | 0.09 | 0.07 | enet | 8 | 0.09 | 9.9e-09 | 5.4 | 5.7 | 1.1e-08 | -0.30 | 0.00 | 1.00 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC9A3R2 | 0.06 | 0.03 | lasso | 5 | 0.03 | 3.7e-04 | -4.7 | 6.1 | 1.3e-09 | -0.60 | 0.02 | 0.91 | FALSE |