Hub : Genes

RAB11FIP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.150	0.0550	8.3e-04	0.065	NA	0.065	NA	0.086	1.9e-04	NA	1.8e-04	NA	1.9e-05
2	GTEx	Skin Sun Exposed Lower leg	0.123	0.0410	4.4e-04	0.059	NA	0.058	NA	0.055	1.3e-05	NA	1.4e-05	NA	2.3e-05
3	YFS	Blood	0.082	0.0202	5.1e-08	0.017	0.037	0.037	0.041	0.019	2.2e-06	2.7e-12	2.5e-12	2.2e-13	6.4e-07
4	TCGA	Thyroid Carcinoma	0.049	0.0330	8.6e-03	0.012	0.011	0.020	NA	0.008	2.0e-02	2.4e-02	4.2e-03	NA	5.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	1.0	0.0	-1.0	-0.5	0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	0.0	-1.1	-0.7	0.0
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	0.1	0.2	0.7	0.8
Depression (Nagel 2018)	0.1	0.2	0.3	0.3	0.3	0.6	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.4	1.2	0.1	0.7	-0.3
Neuroticism (Nagel 2018)	0.3	0.6	1.6	0.8	1.2	-0.4	0.3
Schizophrenia (2018)	0.4	0.8	2.7	-1.7	-0.6	-0.4	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.1	0.0
Worry (Nagel 2018)	1.0	2.2	4.1	0.9	2.0	-1.9	-0.0
Alzheimer’s Disease (in mother)	0.9	1.0	1.8	0.7	0.7	-1.2	-1.3
Alzheimer’s Disease (in father)	1.3	1.4	2.1	1.5	1.4	-0.4	-1.2
Alzheimer’s Disease (including proxy)	3.4	5.0	7.7	2.5	1.8	-1.6	-2.8
Crohns Disease (2017)	0.8	1.7	3.1	-1.8	-0.7	1.6	0.8
Irritable Bowel Disease (IBD)	1.1	2.6	3.7	-1.9	-1.9	1.4	1.2
Ulcerative Colitis (UC)	0.9	1.8	3.7	-1.2	-1.9	1.0	1.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.5	0.9	2.0	-1.4	-0.4	0.6	1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.2	0.8	-0.0	2.1	0.3
Breast Cancer	0.9	2.1	6.9	-0.5	-0.3	2.6	1.1
Ovarian Cancer	0.4	0.6	1.3	-0.6	-1.1	0.3	0.7
Prostate Cancer	3.6	5.1	6.0	-2.1	-2.2	2.5	2.2
Age at First Birth	0.5	0.7	1.6	-0.8	-1.3	-0.5	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-1.0	-0.4	-0.7	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.1	0.4	0.0	-0.4	-0.6	0.0
Mean Putamen Volume	0.8	0.9	1.9	0.3	1.2	1.4	0.3
Fasting Glucose	0.5	0.6	1.8	-0.6	-0.0	1.3	0.4
HbA1C	0.4	0.5	1.1	-0.4	0.8	1.0	0.1
HDL Cholesterol	0.1	0.2	0.8	0.3	0.4	0.9	0.0
LDL Cholesterol	0.0	0.1	0.2	0.2	0.4	-0.2	0.0
Lupus	1.8	2.7	4.6	1.3	2.0	2.1	-0.8
Neuroticism (2016)	0.4	0.6	1.8	0.6	1.4	0.3	-0.5
Primary Biliary Cirrhosis	0.3	0.5	1.0	-0.7	0.1	0.6	1.0
Rheumatoid Arthritis	1.0	1.3	2.8	1.7	1.1	-1.1	0.0
Schizophrenia (2014)	0.2	0.5	1.5	0.0	-1.2	-0.6	0.0
Triglycerides	0.7	1.2	2.6	1.5	1.6	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.1	0.4	0.0	-0.7	0.3	0.0
Blood Eosinophil Count	0.2	1.3	2.4	-1.4	-0.5	-0.7	1.5
Blood Platelet Count	3.3	38.8	139.2	-0.0	1.2	-11.8	-3.8
Blood Red Count	1.1	10.8	18.4	-4.3	-1.0	-3.7	3.2
Blood White Count	0.0	0.3	0.7	-0.7	0.0	-0.1	0.8
Heel T-Score	0.2	1.4	3.3	1.8	0.5	0.5	-1.4
BMI	1.2	7.2	12.5	-3.5	-2.5	0.7	3.1
Height	0.8	15.6	22.6	-4.8	-3.9	2.7	4.1
Waist Hip Ratio (WHR)	0.2	0.8	1.9	-0.2	1.4	-1.1	-0.2
Systolic Blood Pressure	0.1	0.5	1.2	-1.1	-0.7	-0.3	0.5
Smoking Status	0.7	1.8	2.6	0.9	1.4	-1.3	-1.6
Allergy or Eczema	0.9	2.4	5.4	-1.4	-0.5	2.3	1.4
Cardiovascular Disease	0.4	1.3	4.2	-0.8	0.1	-2.0	0.4
Hypothyroidism (self reported)	0.7	1.6	3.6	0.9	0.7	-1.3	-1.9
Respiratory disease	0.2	0.4	0.9	-0.9	0.3	0.7	-0.4
Type 2 Diabetes (T2D) (2018)	2.3	4.4	13.7	1.5	3.7	-0.4	-1.2
Lung FEV1/FVC ratio	0.8	4.2	10.8	0.9	2.2	3.3	0.0
Lung FVC	1.5	7.7	13.9	3.7	2.2	-0.3	-3.5
Neuroticism	0.2	0.5	1.1	-0.3	0.7	-0.5	1.1
Chronotype (morning person)	2.2	5.2	7.7	-2.8	-2.5	-1.0	2.3
Hair Pigment	0.0	0.5	1.1	-1.1	0.1	0.1	0.9
Tanning	0.8	9.4	15.1	-3.9	-3.9	-0.1	2.8
Hand grip strength (left)	0.3	0.8	1.7	-1.3	-0.9	0.8	-0.2
Number of treatments/medications taken	2.0	3.6	6.9	-2.5	-0.9	-0.5	2.6
Average weekly spirits intake	0.4	0.5	2.1	-0.2	-0.1	-1.5	-0.1
Sensitivity / hurt feelings	0.0	0.0	0.2	0.0	-0.0	0.0	0.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	-0.8	-1.1	-0.2	0.4
Hearing difficulty/problems: Yes	1.0	1.5	3.4	-1.1	-0.8	0.9	1.8
Relative age of first facial hair	0.7	1.5	3.6	0.8	0.7	-1.1	-1.9
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	4.4	1.8	1.4	-0.5	-2.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.9	-0.7	0.3	0.9	1.4
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.1	-0.1	-0.8	0.7
Systolic blood pressure, automated reading	0.4	1.1	1.7	-1.3	-1.1	0.1	1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.5	-0.6	0.2	1.0
Angina	0.2	0.3	1.1	-0.2	-0.2	-0.1	1.1
Medication for hormone replacement therapy	1.3	1.4	3.0	-1.3	-0.8	0.7	1.7
Vitamin and mineral supplements	0.8	1.1	1.8	0.7	1.2	1.4	-0.8
Supplements: Zinc	0.9	1.0	3.1	-0.4	-0.7	-1.7	-0.3
Medication: Co-codamol	1.3	1.5	4.2	-0.9	-0.1	-2.0	0.9
Medication: Metformin	1.2	1.6	5.0	0.2	2.2	-1.1	-0.5
Diabetes (father)	2.0	2.4	4.9	1.1	2.2	-1.5	-1.1
Diabetes (mother)	0.9	1.2	4.2	0.4	2.0	-0.5	-0.3
Severe depression (siblings)	1.5	1.7	3.0	-1.7	-0.6	0.9	1.6
Pack years adult smoking proportion	0.7	1.0	3.0	-0.9	-0.5	-1.7	0.3
Impedance of leg (right)	3.0	14.6	21.4	4.5	4.6	-1.5	-3.7
Leg fat-free mass (left)	4.2	22.2	36.0	-6.0	-4.9	1.6	5.1
Trunk fat percentage	1.5	5.9	11.6	-2.8	-1.9	-0.8	3.4
Hand grip strength (right)	0.1	0.3	0.7	0.3	0.4	-0.5	-0.8
Townsend deprivation index at recruitment	4.2	5.9	9.7	1.6	2.6	-3.1	-2.2
Current tobacco smoking	0.5	0.8	1.8	-0.2	1.2	-1.3	-0.4
Average weekly fortified wine intake	0.7	0.8	1.5	0.6	1.2	0.9	-0.7
Maternal smoking around birth	0.4	0.5	1.8	0.2	0.3	0.3	-1.3
Fed-up feelings	0.0	0.1	0.2	-0.1	-0.2	-0.4	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.0	1.1	1.4	-0.6	-0.8
Relative age voice broke	0.5	0.7	1.1	1.0	0.8	-1.1	-0.4
Taking other prescription medications	3.5	5.5	11.1	-3.3	-2.2	0.2	2.4
Age when periods started (menarche)	1.7	4.1	6.5	2.4	2.0	-0.6	-2.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.5	0.1	-0.8	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	0.1	-0.8	-0.9	-1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-1.0	-0.4	-0.4	0.6
Qualifications: CSEs or equivalent	2.7	3.6	6.1	2.0	2.5	0.8	-1.9
Serious illness, injury or assault to yourself	1.5	1.8	5.0	-2.2	-1.4	-0.1	0.5
High blood pressure	0.6	1.6	3.3	-0.9	-0.4	-1.8	1.4
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.7	-0.9	0.6	1.9	0.6
Multivitamins +/- minerals	1.6	2.1	4.8	-1.1	-1.2	-0.9	2.2
Stomach or abdominal pain in last month	0.9	1.1	3.8	-1.9	0.2	0.5	0.6
Supplements: Glucosamine	0.1	0.1	0.2	0.5	0.4	-0.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.7	-0.6	0.2	-1.6	0.6
Medication: Atenolol	0.4	0.6	1.3	-0.2	0.8	-1.2	0.5
Medication: Levothyroxine sodium	0.8	1.4	2.3	1.5	1.0	-0.6	-1.4
Sitting height	1.2	8.5	12.0	-3.5	-2.9	2.6	2.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	-0.9	-0.5	0.5	0.2
High blood pressure (mother)	2.3	3.2	5.4	2.3	2.3	-0.2	-1.5
Body mass index (BMI)	2.3	9.6	15.8	-4.0	-2.8	-0.2	3.8
Impedance of leg (left)	3.7	18.0	25.6	5.1	4.7	-2.0	-4.5
Leg predicted mass (left)	4.3	22.6	36.5	-6.0	-4.9	1.6	5.2
Trunk fat mass	2.8	11.9	20.3	-4.3	-3.0	-0.1	4.5
Waist circumference	3.7	13.5	26.2	-5.1	-3.0	-0.4	4.3
Number of incorrect matches in round	5.1	8.5	13.4	-3.6	-2.2	1.6	3.7
Past tobacco smoking	0.9	1.7	4.3	-1.3	-0.5	0.6	2.1
Alcohol usually taken with meals	0.9	1.4	4.5	-0.1	0.7	2.1	0.7
Nervous feelings	0.6	1.0	2.2	0.9	1.5	-1.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.5	0.4	-0.6	0.0
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.4	0.5	-0.6	0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	0.2	0.2	0.1	-0.7
Had menopause	0.1	0.1	0.4	0.2	-0.6	-0.0	0.1
Had other major operations	0.4	0.5	1.2	-0.9	-1.1	-0.1	0.1
Forced vital capacity (FVC)	0.3	1.1	1.4	0.9	1.2	1.0	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.0	-0.7	-0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.2	-1.1	-0.4	-1.0	0.9
Qualifications: None of the above	0.2	0.4	1.2	0.1	0.6	-1.1	-0.3
Financial difficulties in last 2 years	1.2	1.6	4.3	-2.1	-1.0	0.4	1.0
Mouth/teeth dental problems	0.4	0.6	0.8	-0.4	-0.7	0.9	-0.8
Heart attack	0.6	0.7	1.4	-1.1	-0.6	-0.1	1.2
Allergy	0.6	1.3	3.0	1.7	0.3	-1.0	-1.0
Pain all over the body in last month	0.2	0.2	0.5	-0.1	0.6	-0.7	-0.2
Diabetes (self-reported)	1.2	1.9	6.5	0.9	2.5	-0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	0.2	0.2	0.8	0.3
Medication: Ramipril	1.5	2.0	5.5	-1.2	-0.7	-0.6	2.4
Medication: Simvastatin	0.1	0.1	0.3	0.3	0.3	0.5	0.4
Fluid intelligence score	0.5	1.1	3.5	0.1	-0.8	1.9	-0.1
Illnesses of siblings	0.9	1.3	4.7	0.5	-0.3	2.2	0.2
Neuroticism score	0.2	0.4	0.9	-0.0	0.2	-0.9	0.9
Weight	4.3	21.1	35.3	-5.9	-4.4	1.1	5.3
Impedance of arm (right)	1.9	8.6	13.2	3.6	3.1	-0.2	-3.4
Arm fat percentage (right)	1.4	5.3	8.9	-2.9	-2.0	-0.4	3.0
Trunk fat-free mass	3.7	21.4	37.0	-6.1	-4.6	2.2	4.7
Hip circumference	5.0	21.5	34.3	-5.9	-4.5	0.9	5.5
Time employed in main current job	1.7	2.0	4.0	-2.0	-1.5	-0.2	1.3
Alcohol intake versus 10 years previously	1.3	2.0	3.4	1.4	1.2	1.8	-1.1
Father’s age at death	0.7	1.0	2.9	-0.4	-0.7	1.7	0.5
Worrier / anxious feelings	1.1	2.1	5.0	1.8	2.2	-0.0	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.9	-0.8	-0.0	-1.7	0.6
Falls in the last year	8.7	11.8	22.3	-4.7	-3.0	0.8	3.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	0.6	0.2	0.1
Number of live births	0.2	0.3	0.8	-0.9	-0.5	-0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.4	1.4	2.1	1.7	-1.1
Pulse rate	0.7	1.2	3.1	-0.6	-1.8	-1.0	0.5
Happiness	0.1	0.1	0.2	-0.2	0.4	0.3	0.1
Noisy workplace	1.0	1.3	2.2	-1.5	-1.0	0.1	1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.5	1.2	-0.4	0.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.4	0.2	1.0	-1.6	-0.7
Mouth/teeth dental problems: Dentures	1.0	1.8	4.5	-1.5	-0.1	-0.5	2.1
Asthma	0.2	0.4	0.5	0.2	0.6	0.7	-0.7
Medication: Ibuprofen (e.g. Nurofen)	7.2	9.2	11.0	-3.3	-3.0	2.4	3.3
Medication: Cholesterol lowering	0.5	0.9	1.8	0.1	0.2	-1.2	1.3
Depression (self-reported)	0.0	0.1	0.2	-0.1	-0.1	-0.4	0.1
Medication: Lansoprazole	0.4	0.4	1.1	-0.6	-0.5	-0.1	1.0
Prospective memory result	0.9	1.1	2.2	1.5	1.1	0.8	-0.6
Lung cancer (father)	0.1	0.2	0.5	-0.7	-0.3	-0.3	-0.1
Illnesses of mother	0.6	0.8	1.2	-1.1	-1.1	0.1	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.8	0.6	1.4	2.2	-0.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	-0.6	0.1	-0.2	0.2
Impedance of arm (left)	1.6	7.3	11.1	3.3	3.0	-0.9	-2.8
Arm fat mass (right)	2.7	11.0	18.1	-4.2	-3.0	0.3	4.1
Trunk predicted mass	3.8	21.4	36.8	-6.1	-4.7	2.2	4.7
Standing height	1.5	15.1	22.9	-4.8	-3.8	2.9	3.8
Length of working week for main job	3.3	3.6	4.8	-2.2	-1.7	1.6	2.1
Exposure to tobacco smoke at home	0.5	0.5	1.2	-1.1	-0.7	0.2	0.6
Breastfed as a baby	0.1	0.2	0.5	0.0	0.2	-0.7	0.3
Tense / ‘highly strung’	0.7	1.2	4.6	-0.2	-0.2	-2.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.8	-0.5	-0.6	-0.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.2	0.3	-0.5	-0.2
Birth weight of first child	1.0	1.8	3.1	-1.2	-0.9	1.8	1.3
Peak expiratory flow (PEF)	0.3	0.6	2.0	0.2	1.4	0.1	-0.7
Pulse wave reflection index	0.8	1.0	3.5	-0.2	0.5	-1.9	-0.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	-0.1	0.2	-1.6	0.6
Loud music exposure frequency	4.0	4.4	6.7	2.5	2.1	-0.3	-2.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.2	0.8	-0.6	-0.8	-1.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.4	0.5	0.2	0.8
Blood clot in the leg (DVT)	0.2	0.3	0.8	0.6	0.2	0.0	-0.9
Medication: Paracetamol	1.9	3.2	5.2	-2.3	-1.8	1.4	1.5
Headache pain in last month	1.6	2.8	3.7	-1.8	-0.9	1.9	1.9
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.6	0.1	0.2	1.6	-1.1
Glaucoma (self-reported)	0.2	0.3	0.8	-0.2	0.5	-0.9	0.3
Gout (self-reported)	0.3	0.5	1.2	1.1	-0.1	-0.6	-0.5
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	4.0	1.5	0.8	-1.2	-2.0
Medication: Amlodipine	0.7	1.0	1.6	-1.3	-0.5	-1.2	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.2	0.7	0.9	-0.5
Birth weight	0.3	0.6	2.5	0.1	0.1	-1.6	0.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.1	-0.3	0.3	-0.5
High blood pressure (siblings)	0.6	0.9	3.2	-0.4	-0.2	-1.8	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.6	2.1	0.1	0.6	1.4	-0.4
Body fat percentage	1.4	5.4	10.7	-2.7	-1.6	-1.1	3.3
Leg fat percentage (right)	1.3	4.8	8.5	-2.7	-1.3	-1.2	2.9
Arm fat-free mass (right)	3.7	19.1	32.4	-5.7	-4.3	1.1	4.9
Exposure to tobacco smoke outside home	1.0	1.3	2.7	-0.2	1.2	1.6	1.0
Comparative body size at age 10	0.3	0.9	1.2	-1.1	-0.3	-1.0	1.0
Number of full brothers	0.3	0.4	0.9	-0.9	0.7	0.4	0.1
Worry too long after embarrassment	0.4	0.7	1.9	0.1	0.0	1.0	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	-1.1	-0.9	-0.9	-0.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.8	-0.9	-0.1	-0.1	-0.1
Number of children fathered	0.8	0.9	1.4	-1.1	-0.5	0.8	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.0	-0.8	-0.5	-0.9	1.0
Age at first live birth	0.8	1.3	3.1	-0.9	-1.8	1.1	-0.4
Pulse wave peak to peak time	0.1	0.1	0.2	0.3	-0.5	0.3	0.1
Health satisfaction	0.9	1.2	2.3	-1.4	-0.7	-0.4	1.5
Shortness of breath walking on level ground	1.7	2.0	3.9	-1.9	-0.1	-0.6	2.0
Qualifications: College or University degree	0.3	0.8	1.5	-0.6	-1.1	1.2	0.5
Eye problems/disorders: None of the above	0.3	0.3	0.6	0.6	0.3	0.8	-0.6
Mouth/teeth dental problems: Loose teeth	1.5	1.7	4.3	1.4	0.7	-0.4	-2.1
Emphysema/chronic bronchitis	0.2	0.3	0.7	-0.4	-0.4	-0.8	0.0
Medication for pain relief, constipation, heartburn	1.7	2.8	5.6	2.4	1.0	0.3	-2.2
Neck or shoulder pain in last month	0.4	0.6	2.4	-0.0	1.6	-0.3	0.1
Medication: Blood pressure	1.1	1.9	6.2	-0.3	-0.4	-2.5	1.1
Angina (self-reported)	0.3	0.3	1.1	-0.3	-0.2	-0.4	1.1
Migraine (self-reported)	1.1	1.4	3.8	-1.2	0.2	2.0	0.5
Medication: Ibuprofen	4.3	5.2	7.2	-2.4	-1.6	2.2	2.7
Medication: Allopurinol	0.8	1.0	1.8	1.3	0.7	-0.6	-1.2
Medication: Omeprazole	1.6	1.9	3.1	-1.8	-1.0	-0.7	1.7
Medication: Seretide 50 evohaler	0.2	0.3	0.8	-0.1	-0.3	0.9	-0.4
Mean time to correctly identify matches	0.2	0.4	0.8	-0.6	-0.0	0.6	0.9
Heart disease (mother)	1.7	2.1	3.7	-1.5	-1.9	-0.5	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	5.1	-0.8	-0.1	-2.3	0.6
Whole body fat mass	2.9	12.2	20.7	-4.3	-3.0	-0.3	4.5
Leg fat mass (right)	2.9	11.2	18.7	-4.3	-2.8	-0.2	4.3
Arm predicted mass (right)	4.1	21.2	35.9	-6.0	-4.6	1.4	5.1
Pulse rate, automated reading	0.3	1.1	2.5	-0.4	-1.6	-1.3	0.1
Alcohol intake frequency.	1.6	3.7	5.0	2.1	2.2	1.4	-1.9
Comparative height size at age 10	1.1	6.2	8.6	-2.9	-2.6	1.7	2.5
Number of full sisters	1.6	1.9	3.6	1.9	1.2	-0.4	-1.6
Suffer from ‘nerves’	0.6	1.0	2.7	0.8	1.6	-0.7	-0.4
Overall health rating	0.6	1.3	3.9	-0.9	-0.1	-2.0	0.6
Chest pain or discomfort	1.0	1.4	3.7	-1.9	-0.7	0.7	1.0
Had major operations	0.5	0.5	1.4	-0.7	-0.5	-1.2	-0.1
Age at last live birth	0.6	0.9	1.9	-1.4	-1.0	0.8	0.5
Family relationship satisfaction	0.9	1.1	2.6	0.9	0.9	1.6	-0.6
Leg pain on walking	0.8	1.0	3.4	-0.8	0.0	-1.8	0.4
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.7	6.9	1.9	2.6	-0.7	-2.0
Commuting to job workplace: Car/motor vehicle	1.8	2.1	2.2	-1.4	-1.5	1.5	1.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.4	1.2	0.3	1.2	0.4
Medication: Aspirin	0.8	1.1	3.5	0.7	1.9	-0.4	0.4
Supplements: Vitamin C	0.4	0.5	1.6	-0.4	-0.5	-1.3	-0.3
Knee pain experienced in last month	0.6	0.9	2.9	0.5	0.7	-1.7	0.0
Hypertension (Self-reported)	0.5	1.3	3.1	-0.7	-0.2	-1.8	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	9.5	11.1	17.3	-4.2	-3.3	0.6	4.0
Illnesses of father: Heart disease	0.6	0.9	2.9	-0.4	0.3	0.6	1.7
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.2	1.1	-0.8	-0.2
Smoking status: Previous	0.9	1.4	3.4	1.4	0.2	-0.2	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.7	-0.6	0.1	1.3	-0.4
Whole body fat-free mass	4.0	22.9	38.7	-6.2	-4.9	1.8	5.1
Leg fat-free mass (right)	4.1	21.7	35.0	-5.9	-5.1	1.6	4.8
Arm fat percentage (left)	1.7	6.6	11.8	-3.2	-2.1	-0.6	3.4
Average weekly red wine intake	0.5	0.7	1.7	-1.3	-0.4	-0.8	0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.6	0.4	-0.8	-1.1
Mood swings	0.6	1.0	1.9	-1.0	-0.6	0.9	1.4
Loneliness, isolation	0.4	0.6	0.7	-0.9	-0.7	0.6	0.8
Long-standing illness, disability or infirmity	0.2	0.2	0.8	0.1	0.3	-0.3	-0.9
Ever had bowel cancer screening	0.6	0.6	1.3	-1.1	-0.7	0.0	0.9
Diabetes diagnosed by doctor	0.9	1.4	5.3	-0.0	2.3	-0.4	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.0	-1.1	-1.5	-1.7	-0.1
Friendships satisfaction	0.6	0.8	1.8	-0.5	0.9	1.3	0.2
Qualifications: nursing, teaching	0.6	1.0	1.9	-1.0	-1.4	-0.7	0.7
Commuting to job workplace: Walk	1.1	1.2	1.8	1.3	1.0	0.2	-1.4
Eye problems/disorders: Cataract	0.2	0.3	0.5	-0.1	0.5	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.5	0.6	-0.2	0.2	-0.7
Medication for cholesterol	0.7	1.0	2.7	1.2	-0.2	-0.3	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.7	-1.3	-1.1	0.6	0.6
Back pain experienced in last month	1.3	1.9	4.0	1.3	2.0	1.1	-0.7
Mineral and other dietary supplements	0.3	0.5	0.8	-0.8	-0.9	0.7	0.1
Breast cancer (self-reported)	0.7	0.8	1.8	-0.6	-1.4	0.9	0.0
Asthma (self-reported)	0.3	0.5	0.9	0.4	0.9	0.7	-0.8
Osteoporosis (self-reported)	0.1	0.1	0.2	0.2	0.5	-0.3	-0.2
Osteoarthritis (self-reported)	0.9	1.2	2.2	-1.2	-1.5	0.4	0.9
Medication: Aspirin	0.9	1.2	3.3	0.7	1.8	-1.0	0.4
Medication: Gliclazide	0.6	0.7	2.3	-0.0	1.5	-0.7	0.1
Illnesses of father: None of the above (group 1)	2.1	2.6	8.4	-1.4	-2.9	0.2	0.3
Smoking status: Current	0.8	1.2	2.4	0.2	1.5	-1.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	5.5	1.7	1.3	2.3	-0.8
Whole body water mass	4.0	22.7	37.9	-6.2	-4.8	1.8	5.1
Leg predicted mass (right)	4.0	21.4	34.6	-5.9	-5.0	1.6	4.8
Arm fat mass (left)	2.9	11.9	19.2	-4.4	-3.1	0.0	4.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	-1.1	-0.2	-0.8	-0.0
Average weekly champagne plus white wine intake	1.6	2.2	5.2	-1.2	-1.0	2.3	1.2
Miserableness	0.8	1.4	3.4	1.8	1.5	-0.0	-0.4
Guilty feelings	0.9	1.3	4.3	-0.3	-0.2	-2.1	0.8
Wears glasses or contact lenses	0.4	0.4	1.2	-0.6	-0.0	-0.3	1.1
Ever taken oral contraceptive pill	2.1	2.4	3.3	1.8	1.7	0.1	-1.8
Hearing aid user	1.1	1.3	3.4	-1.2	-1.9	0.1	0.6
Mother’s age at death	1.5	1.9	3.4	1.8	1.6	-0.3	-1.2
Financial situation satisfaction	0.8	1.0	2.7	0.8	0.7	1.6	-0.5
Tinnitus: Yes, now most or all of the time	0.6	0.6	1.5	-0.4	0.6	-1.2	0.8
Commuting to job workplace: Public transport	0.9	1.1	1.8	1.3	0.8	-0.7	-1.2
Eye problems/disorders: Glaucoma	0.9	1.1	3.9	-0.2	-0.4	-2.0	0.3
Medication: Blood pressure	0.6	1.1	2.5	-1.6	-0.3	0.2	1.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	-1.1	-0.1	-0.5	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.8	1.0	1.3	-1.4	-0.2
High cholesterol (Self-reported)	0.3	0.6	1.3	-0.4	0.1	-0.9	1.1
Medication: Bendroflumethiazide	1.2	1.8	3.2	-1.4	-0.7	-1.2	1.8
Medication: Paracetamol	2.1	3.3	5.8	-2.4	-1.6	1.6	1.6
Medication: Lisinopril	0.2	0.3	0.6	-0.8	0.1	-0.2	0.7
Medication: Atorvastatin	0.5	0.6	1.8	-0.3	0.4	-1.4	0.6
Illnesses of father: High blood pressure	0.9	1.1	3.8	0.7	1.9	0.4	-0.2
Alcohol drinker status: Never	0.5	0.6	1.5	-0.9	-0.3	1.2	0.4
Ever smoked	0.8	1.4	2.8	1.4	1.0	-0.3	-1.7
Basal metabolic rate	4.1	22.7	38.6	-6.2	-4.8	1.6	5.1
Leg fat percentage (left)	1.3	4.6	6.8	-2.6	-1.4	-1.6	2.6
Arm fat-free mass (left)	3.5	17.6	29.7	-5.5	-4.2	1.1	4.7
Number of operations (self-reported)	0.3	0.4	1.3	0.2	0.3	-1.1	-0.5
Average weekly beer plus cider intake	0.4	0.6	0.8	-0.5	-0.7	0.9	0.8
Irritability	0.3	0.6	1.1	0.9	-0.3	-0.6	-1.0
Risk taking	2.3	3.3	5.9	-2.4	-1.9	0.7	1.8
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.6	-1.6	0.0	1.9	1.3
Fractured/broken bones in last 5 years	0.8	1.0	3.3	0.6	0.1	-1.8	-0.6
Age started oral contraceptive pill	0.2	0.3	0.7	-0.1	-0.4	0.6	0.8
Diastolic blood pressure, automated reading	0.1	0.3	0.9	0.0	0.9	0.3	-0.6
Ever depressed for a whole week	4.1	5.0	9.3	-3.1	-2.5	0.2	2.1
Unable to work because of sickness or disability	0.2	0.3	0.6	0.1	0.8	0.2	-0.6
Commuting to job workplace: Cycle	0.3	0.4	0.7	0.8	0.8	0.3	-0.2
Myopia	0.5	0.7	1.2	0.9	0.8	-0.3	-1.1
Vascular/heart problems diagnosed by doctor	0.6	1.5	4.6	0.6	0.2	2.1	-1.1
Cholesterol lowering medication	0.5	0.8	2.6	0.5	1.6	-0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	2.9	3.6	5.4	-2.3	-1.5	-1.2	2.3
Pain experienced in last month	0.5	0.8	2.3	0.8	-0.6	1.5	0.0
Supplements: Calcium	1.7	1.9	3.8	1.9	0.7	-0.5	-1.7
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	-0.3	-0.6	-0.9	-0.8
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.4	-1.3	-0.9	0.1	1.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.6	0.5	0.3	-0.7
Heart disease (siblings)	0.3	0.4	1.0	0.2	0.7	-1.0	-0.3
Alcohol drinker status: Previous	1.0	1.1	1.5	1.0	0.9	1.0	-1.2
Pack years of smoking	0.9	1.3	2.0	-1.2	-0.9	-1.4	0.9
Impedance of whole body	2.8	14.2	21.4	4.6	4.2	-1.5	-3.9
Leg fat mass (left)	2.7	10.7	17.6	-4.2	-2.8	-0.5	4.1
Arm predicted mass (left)	3.4	17.4	29.9	-5.5	-4.1	1.3	4.6