TWAS hub - RAB11FIP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.150	0.0550	8.3e-04	0.065	NA	0.065	NA	0.086	1.9e-04	NA	1.8e-04	NA	1.9e-05
2	GTEx	Skin Sun Exposed Lower leg	0.123	0.0410	4.4e-04	0.059	NA	0.058	NA	0.055	1.3e-05	NA	1.4e-05	NA	2.3e-05
3	YFS	Blood	0.082	0.0202	5.1e-08	0.017	0.037	0.037	0.041	0.019	2.2e-06	2.7e-12	2.5e-12	2.2e-13	6.4e-07
4	TCGA	Thyroid Carcinoma	0.049	0.0330	8.6e-03	0.012	0.011	0.020	NA	0.008	2.0e-02	2.4e-02	4.2e-03	NA	5.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	9.5	11.1	17.3	-4.2	-3.3	0.6	4.0
Falls in the last year	8.7	11.8	22.3	-4.7	-3.0	0.8	3.8
Medication: Ibuprofen (e.g. Nurofen)	7.2	9.2	11.0	-3.3	-3.0	2.4	3.3
Number of incorrect matches in round	5.1	8.5	13.4	-3.6	-2.2	1.6	3.7
Hip circumference	5.0	21.5	34.3	-5.9	-4.5	0.9	5.5
Leg predicted mass (left)	4.3	22.6	36.5	-6.0	-4.9	1.6	5.2
Weight	4.3	21.1	35.3	-5.9	-4.4	1.1	5.3
Medication: Ibuprofen	4.3	5.2	7.2	-2.4	-1.6	2.2	2.7
Leg fat-free mass (left)	4.2	22.2	36.0	-6.0	-4.9	1.6	5.1
Townsend deprivation index at recruitment	4.2	5.9	9.7	1.6	2.6	-3.1	-2.2
Arm predicted mass (right)	4.1	21.2	35.9	-6.0	-4.6	1.4	5.1
Leg fat-free mass (right)	4.1	21.7	35.0	-5.9	-5.1	1.6	4.8
Basal metabolic rate	4.1	22.7	38.6	-6.2	-4.8	1.6	5.1
Ever depressed for a whole week	4.1	5.0	9.3	-3.1	-2.5	0.2	2.1
Loud music exposure frequency	4.0	4.4	6.7	2.5	2.1	-0.3	-2.6
Whole body fat-free mass	4.0	22.9	38.7	-6.2	-4.9	1.8	5.1
Whole body water mass	4.0	22.7	37.9	-6.2	-4.8	1.8	5.1
Leg predicted mass (right)	4.0	21.4	34.6	-5.9	-5.0	1.6	4.8
Trunk predicted mass	3.8	21.4	36.8	-6.1	-4.7	2.2	4.7
Impedance of leg (left)	3.7	18.0	25.6	5.1	4.7	-2.0	-4.5
Waist circumference	3.7	13.5	26.2	-5.1	-3.0	-0.4	4.3
Trunk fat-free mass	3.7	21.4	37.0	-6.1	-4.6	2.2	4.7
Arm fat-free mass (right)	3.7	19.1	32.4	-5.7	-4.3	1.1	4.9
Prostate Cancer	3.6	5.1	6.0	-2.1	-2.2	2.5	2.2
Taking other prescription medications	3.5	5.5	11.1	-3.3	-2.2	0.2	2.4
Arm fat-free mass (left)	3.5	17.6	29.7	-5.5	-4.2	1.1	4.7
Alzheimer’s Disease (including proxy)	3.4	5.0	7.7	2.5	1.8	-1.6	-2.8
Arm predicted mass (left)	3.4	17.4	29.9	-5.5	-4.1	1.3	4.6
Blood Platelet Count	3.3	38.8	139.2	-0.0	1.2	-11.8	-3.8
Length of working week for main job	3.3	3.6	4.8	-2.2	-1.7	1.6	2.1
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.7	6.9	1.9	2.6	-0.7	-2.0
Impedance of leg (right)	3.0	14.6	21.4	4.5	4.6	-1.5	-3.7
Whole body fat mass	2.9	12.2	20.7	-4.3	-3.0	-0.3	4.5
Leg fat mass (right)	2.9	11.2	18.7	-4.3	-2.8	-0.2	4.3
Arm fat mass (left)	2.9	11.9	19.2	-4.4	-3.1	0.0	4.3
Medication: Omeprazole (e.g. Zanprol)	2.9	3.6	5.4	-2.3	-1.5	-1.2	2.3
Trunk fat mass	2.8	11.9	20.3	-4.3	-3.0	-0.1	4.5
Impedance of whole body	2.8	14.2	21.4	4.6	4.2	-1.5	-3.9
Qualifications: CSEs or equivalent	2.7	3.6	6.1	2.0	2.5	0.8	-1.9
Arm fat mass (right)	2.7	11.0	18.1	-4.2	-3.0	0.3	4.1
Leg fat mass (left)	2.7	10.7	17.6	-4.2	-2.8	-0.5	4.1
Type 2 Diabetes (T2D) (2018)	2.3	4.4	13.7	1.5	3.7	-0.4	-1.2
High blood pressure (mother)	2.3	3.2	5.4	2.3	2.3	-0.2	-1.5
Body mass index (BMI)	2.3	9.6	15.8	-4.0	-2.8	-0.2	3.8
Risk taking	2.3	3.3	5.9	-2.4	-1.9	0.7	1.8
Chronotype (morning person)	2.2	5.2	7.7	-2.8	-2.5	-1.0	2.3
Illnesses of father: None of the above (group 1)	2.1	2.6	8.4	-1.4	-2.9	0.2	0.3
Ever taken oral contraceptive pill	2.1	2.4	3.3	1.8	1.7	0.1	-1.8
Medication: Paracetamol	2.1	3.3	5.8	-2.4	-1.6	1.6	1.6
Number of treatments/medications taken	2.0	3.6	6.9	-2.5	-0.9	-0.5	2.6
Diabetes (father)	2.0	2.4	4.9	1.1	2.2	-1.5	-1.1
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	4.4	1.8	1.4	-0.5	-2.1
Impedance of arm (right)	1.9	8.6	13.2	3.6	3.1	-0.2	-3.4
Medication: Paracetamol	1.9	3.2	5.2	-2.3	-1.8	1.4	1.5
Lupus	1.8	2.7	4.6	1.3	2.0	2.1	-0.8
Commuting to job workplace: Car/motor vehicle	1.8	2.1	2.2	-1.4	-1.5	1.5	1.4
Age when periods started (menarche)	1.7	4.1	6.5	2.4	2.0	-0.6	-2.5
Time employed in main current job	1.7	2.0	4.0	-2.0	-1.5	-0.2	1.3
Shortness of breath walking on level ground	1.7	2.0	3.9	-1.9	-0.1	-0.6	2.0
Medication for pain relief, constipation, heartburn	1.7	2.8	5.6	2.4	1.0	0.3	-2.2
Heart disease (mother)	1.7	2.1	3.7	-1.5	-1.9	-0.5	1.4
Arm fat percentage (left)	1.7	6.6	11.8	-3.2	-2.1	-0.6	3.4
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.6	-1.6	0.0	1.9	1.3
Supplements: Calcium	1.7	1.9	3.8	1.9	0.7	-0.5	-1.7
Multivitamins +/- minerals	1.6	2.1	4.8	-1.1	-1.2	-0.9	2.2
Impedance of arm (left)	1.6	7.3	11.1	3.3	3.0	-0.9	-2.8
Headache pain in last month	1.6	2.8	3.7	-1.8	-0.9	1.9	1.9
Medication: Omeprazole	1.6	1.9	3.1	-1.8	-1.0	-0.7	1.7
Alcohol intake frequency.	1.6	3.7	5.0	2.1	2.2	1.4	-1.9
Number of full sisters	1.6	1.9	3.6	1.9	1.2	-0.4	-1.6
Average weekly champagne plus white wine intake	1.6	2.2	5.2	-1.2	-1.0	2.3	1.2
Lung FVC	1.5	7.7	13.9	3.7	2.2	-0.3	-3.5
Severe depression (siblings)	1.5	1.7	3.0	-1.7	-0.6	0.9	1.6
Trunk fat percentage	1.5	5.9	11.6	-2.8	-1.9	-0.8	3.4
Serious illness, injury or assault to yourself	1.5	1.8	5.0	-2.2	-1.4	-0.1	0.5
Medication: Ramipril	1.5	2.0	5.5	-1.2	-0.7	-0.6	2.4
Standing height	1.5	15.1	22.9	-4.8	-3.8	2.9	3.8
Mouth/teeth dental problems: Loose teeth	1.5	1.7	4.3	1.4	0.7	-0.4	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.0	-1.1	-1.5	-1.7	-0.1
Mother’s age at death	1.5	1.9	3.4	1.8	1.6	-0.3	-1.2
Arm fat percentage (right)	1.4	5.3	8.9	-2.9	-2.0	-0.4	3.0
Body fat percentage	1.4	5.4	10.7	-2.7	-1.6	-1.1	3.3
Alzheimer’s Disease (in father)	1.3	1.4	2.1	1.5	1.4	-0.4	-1.2
Medication for hormone replacement therapy	1.3	1.4	3.0	-1.3	-0.8	0.7	1.7
Medication: Co-codamol	1.3	1.5	4.2	-0.9	-0.1	-2.0	0.9
Alcohol intake versus 10 years previously	1.3	2.0	3.4	1.4	1.2	1.8	-1.1
Leg fat percentage (right)	1.3	4.8	8.5	-2.7	-1.3	-1.2	2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	5.1	-0.8	-0.1	-2.3	0.6
Back pain experienced in last month	1.3	1.9	4.0	1.3	2.0	1.1	-0.7
Leg fat percentage (left)	1.3	4.6	6.8	-2.6	-1.4	-1.6	2.6
BMI	1.2	7.2	12.5	-3.5	-2.5	0.7	3.1
Medication: Metformin	1.2	1.6	5.0	0.2	2.2	-1.1	-0.5
Sitting height	1.2	8.5	12.0	-3.5	-2.9	2.6	2.6
Financial difficulties in last 2 years	1.2	1.6	4.3	-2.1	-1.0	0.4	1.0
Diabetes (self-reported)	1.2	1.9	6.5	0.9	2.5	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	5.5	1.7	1.3	2.3	-0.8
Medication: Bendroflumethiazide	1.2	1.8	3.2	-1.4	-0.7	-1.2	1.8
Irritable Bowel Disease (IBD)	1.1	2.6	3.7	-1.9	-1.9	1.4	1.2
Blood Red Count	1.1	10.8	18.4	-4.3	-1.0	-3.7	3.2
Worrier / anxious feelings	1.1	2.1	5.0	1.8	2.2	-0.0	-0.5
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	4.0	1.5	0.8	-1.2	-2.0
Medication: Blood pressure	1.1	1.9	6.2	-0.3	-0.4	-2.5	1.1
Migraine (self-reported)	1.1	1.4	3.8	-1.2	0.2	2.0	0.5
Comparative height size at age 10	1.1	6.2	8.6	-2.9	-2.6	1.7	2.5
Commuting to job workplace: Walk	1.1	1.2	1.8	1.3	1.0	0.2	-1.4
Hearing aid user	1.1	1.3	3.4	-1.2	-1.9	0.1	0.6
Worry (Nagel 2018)	1.0	2.2	4.1	0.9	2.0	-1.9	-0.0
Rheumatoid Arthritis	1.0	1.3	2.8	1.7	1.1	-1.1	0.0
Hearing difficulty/problems: Yes	1.0	1.5	3.4	-1.1	-0.8	0.9	1.8
Noisy workplace	1.0	1.3	2.2	-1.5	-1.0	0.1	1.4
Mouth/teeth dental problems: Dentures	1.0	1.8	4.5	-1.5	-0.1	-0.5	2.1
Birth weight of first child	1.0	1.8	3.1	-1.2	-0.9	1.8	1.3
Exposure to tobacco smoke outside home	1.0	1.3	2.7	-0.2	1.2	1.6	1.0
Chest pain or discomfort	1.0	1.4	3.7	-1.9	-0.7	0.7	1.0
Heart attack/myocardial infarction (self-reported)	1.0	1.2	2.4	-1.3	-0.9	0.1	1.5
Alcohol drinker status: Previous	1.0	1.1	1.5	1.0	0.9	1.0	-1.2
Alzheimer’s Disease (in mother)	0.9	1.0	1.8	0.7	0.7	-1.2	-1.3
Ulcerative Colitis (UC)	0.9	1.8	3.7	-1.2	-1.9	1.0	1.0
Breast Cancer	0.9	2.1	6.9	-0.5	-0.3	2.6	1.1
Allergy or Eczema	0.9	2.4	5.4	-1.4	-0.5	2.3	1.4
Supplements: Zinc	0.9	1.0	3.1	-0.4	-0.7	-1.7	-0.3
Diabetes (mother)	0.9	1.2	4.2	0.4	2.0	-0.5	-0.3
Stomach or abdominal pain in last month	0.9	1.1	3.8	-1.9	0.2	0.5	0.6
Past tobacco smoking	0.9	1.7	4.3	-1.3	-0.5	0.6	2.1
Alcohol usually taken with meals	0.9	1.4	4.5	-0.1	0.7	2.1	0.7
Illnesses of siblings	0.9	1.3	4.7	0.5	-0.3	2.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.4	0.2	1.0	-1.6	-0.7
Prospective memory result	0.9	1.1	2.2	1.5	1.1	0.8	-0.6
Health satisfaction	0.9	1.2	2.3	-1.4	-0.7	-0.4	1.5
Family relationship satisfaction	0.9	1.1	2.6	0.9	0.9	1.6	-0.6
Smoking status: Previous	0.9	1.4	3.4	1.4	0.2	-0.2	-1.9
Diabetes diagnosed by doctor	0.9	1.4	5.3	-0.0	2.3	-0.4	0.5
Osteoarthritis (self-reported)	0.9	1.2	2.2	-1.2	-1.5	0.4	0.9
Medication: Aspirin	0.9	1.2	3.3	0.7	1.8	-1.0	0.4
Guilty feelings	0.9	1.3	4.3	-0.3	-0.2	-2.1	0.8
Commuting to job workplace: Public transport	0.9	1.1	1.8	1.3	0.8	-0.7	-1.2
Eye problems/disorders: Glaucoma	0.9	1.1	3.9	-0.2	-0.4	-2.0	0.3
Illnesses of father: High blood pressure	0.9	1.1	3.8	0.7	1.9	0.4	-0.2
Pack years of smoking	0.9	1.3	2.0	-1.2	-0.9	-1.4	0.9
Crohns Disease (2017)	0.8	1.7	3.1	-1.8	-0.7	1.6	0.8
Mean Putamen Volume	0.8	0.9	1.9	0.3	1.2	1.4	0.3
Height	0.8	15.6	22.6	-4.8	-3.9	2.7	4.1
Lung FEV1/FVC ratio	0.8	4.2	10.8	0.9	2.2	3.3	0.0
Tanning	0.8	9.4	15.1	-3.9	-3.9	-0.1	2.8
Vitamin and mineral supplements	0.8	1.1	1.8	0.7	1.2	1.4	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.0	1.1	1.4	-0.6	-0.8
Medication: Levothyroxine sodium	0.8	1.4	2.3	1.5	1.0	-0.6	-1.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.4	1.4	2.1	1.7	-1.1
Pulse wave reflection index	0.8	1.0	3.5	-0.2	0.5	-1.9	-0.5
Number of children fathered	0.8	0.9	1.4	-1.1	-0.5	0.8	1.2
Age at first live birth	0.8	1.3	3.1	-0.9	-1.8	1.1	-0.4
Medication: Allopurinol	0.8	1.0	1.8	1.3	0.7	-0.6	-1.2
Leg pain on walking	0.8	1.0	3.4	-0.8	0.0	-1.8	0.4
Medication: Aspirin	0.8	1.1	3.5	0.7	1.9	-0.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.7	-1.3	-1.1	0.6	0.6
Smoking status: Current	0.8	1.2	2.4	0.2	1.5	-1.3	-0.8
Miserableness	0.8	1.4	3.4	1.8	1.5	-0.0	-0.4
Financial situation satisfaction	0.8	1.0	2.7	0.8	0.7	1.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.8	1.0	1.3	-1.4	-0.2
Ever smoked	0.8	1.4	2.8	1.4	1.0	-0.3	-1.7
Fractured/broken bones in last 5 years	0.8	1.0	3.3	0.6	0.1	-1.8	-0.6
Triglycerides	0.7	1.2	2.6	1.5	1.6	0.0	0.0
Smoking Status	0.7	1.8	2.6	0.9	1.4	-1.3	-1.6
Hypothyroidism (self reported)	0.7	1.6	3.6	0.9	0.7	-1.3	-1.9
Relative age of first facial hair	0.7	1.5	3.6	0.8	0.7	-1.1	-1.9
Pack years adult smoking proportion	0.7	1.0	3.0	-0.9	-0.5	-1.7	0.3
Average weekly fortified wine intake	0.7	0.8	1.5	0.6	1.2	0.9	-0.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.7	-0.6	0.2	-1.6	0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.2	-1.1	-0.4	-1.0	0.9
Father’s age at death	0.7	1.0	2.9	-0.4	-0.7	1.7	0.5
Pulse rate	0.7	1.2	3.1	-0.6	-1.8	-1.0	0.5
Tense / ‘highly strung’	0.7	1.2	4.6	-0.2	-0.2	-2.1	-0.5
Medication: Amlodipine	0.7	1.0	1.6	-1.3	-0.5	-1.2	0.8
Medication for cholesterol	0.7	1.0	2.7	1.2	-0.2	-0.3	-1.6
Breast cancer (self-reported)	0.7	0.8	1.8	-0.6	-1.4	0.9	0.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.9	-0.7	0.3	0.9	1.4
High blood pressure	0.6	1.6	3.3	-0.9	-0.4	-1.8	1.4
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.7	-0.9	0.6	1.9	0.6
Nervous feelings	0.6	1.0	2.2	0.9	1.5	-1.0	-0.4
Heart attack	0.6	0.7	1.4	-1.1	-0.6	-0.1	1.2
Allergy	0.6	1.3	3.0	1.7	0.3	-1.0	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.9	-0.8	-0.0	-1.7	0.6
Illnesses of mother	0.6	0.8	1.2	-1.1	-1.1	0.1	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.8	0.6	1.4	2.2	-0.5
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	-0.1	0.2	-1.6	0.6
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.6	0.1	0.2	1.6	-1.1
High blood pressure (siblings)	0.6	0.9	3.2	-0.4	-0.2	-1.8	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.0	-0.8	-0.5	-0.9	1.0
Suffer from ‘nerves’	0.6	1.0	2.7	0.8	1.6	-0.7	-0.4
Overall health rating	0.6	1.3	3.9	-0.9	-0.1	-2.0	0.6
Age at last live birth	0.6	0.9	1.9	-1.4	-1.0	0.8	0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.4	1.2	0.3	1.2	0.4
Knee pain experienced in last month	0.6	0.9	2.9	0.5	0.7	-1.7	0.0
Illnesses of father: Heart disease	0.6	0.9	2.9	-0.4	0.3	0.6	1.7
Mood swings	0.6	1.0	1.9	-1.0	-0.6	0.9	1.4
Ever had bowel cancer screening	0.6	0.6	1.3	-1.1	-0.7	0.0	0.9
Friendships satisfaction	0.6	0.8	1.8	-0.5	0.9	1.3	0.2
Qualifications: nursing, teaching	0.6	1.0	1.9	-1.0	-1.4	-0.7	0.7
Medication: Gliclazide	0.6	0.7	2.3	-0.0	1.5	-0.7	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.6	1.5	-0.4	0.6	-1.2	0.8
Medication: Blood pressure	0.6	1.1	2.5	-1.6	-0.3	0.2	1.3
Vascular/heart problems diagnosed by doctor	0.6	1.5	4.6	0.6	0.2	2.1	-1.1
Reaction Time	0.5	0.9	2.0	-1.4	-0.4	0.6	1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.2	0.8	-0.0	2.1	0.3
Age at First Birth	0.5	0.7	1.6	-0.8	-1.3	-0.5	-0.5
Fasting Glucose	0.5	0.6	1.8	-0.6	-0.0	1.3	0.4
Current tobacco smoking	0.5	0.8	1.8	-0.2	1.2	-1.3	-0.4
Relative age voice broke	0.5	0.7	1.1	1.0	0.8	-1.1	-0.4
Fluid intelligence score	0.5	1.1	3.5	0.1	-0.8	1.9	-0.1
Medication: Cholesterol lowering	0.5	0.9	1.8	0.1	0.2	-1.2	1.3
Exposure to tobacco smoke at home	0.5	0.5	1.2	-1.1	-0.7	0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.2	0.8	-0.6	-0.8	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	-1.1	-0.9	-0.9	-0.1
Had major operations	0.5	0.5	1.4	-0.7	-0.5	-1.2	-0.1
Hypertension (Self-reported)	0.5	1.3	3.1	-0.7	-0.2	-1.8	1.2
Average weekly red wine intake	0.5	0.7	1.7	-1.3	-0.4	-0.8	0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.2	0.6	0.4	-0.8	-1.1
Medication: Atorvastatin	0.5	0.6	1.8	-0.3	0.4	-1.4	0.6
Alcohol drinker status: Never	0.5	0.6	1.5	-0.9	-0.3	1.2	0.4
Myopia	0.5	0.7	1.2	0.9	0.8	-0.3	-1.1
Cholesterol lowering medication	0.5	0.8	2.6	0.5	1.6	-0.5	-0.3
Pain experienced in last month	0.5	0.8	2.3	0.8	-0.6	1.5	0.0
Schizophrenia (2018)	0.4	0.8	2.7	-1.7	-0.6	-0.4	0.0
Ovarian Cancer	0.4	0.6	1.3	-0.6	-1.1	0.3	0.7
HbA1C	0.4	0.5	1.1	-0.4	0.8	1.0	0.1
Neuroticism (2016)	0.4	0.6	1.8	0.6	1.4	0.3	-0.5
Cardiovascular Disease	0.4	1.3	4.2	-0.8	0.1	-2.0	0.4
Average weekly spirits intake	0.4	0.5	2.1	-0.2	-0.1	-1.5	-0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	-0.8	-1.1	-0.2	0.4
Systolic blood pressure, automated reading	0.4	1.1	1.7	-1.3	-1.1	0.1	1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.5	-0.6	0.2	1.0
Maternal smoking around birth	0.4	0.5	1.8	0.2	0.3	0.3	-1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-1.0	-0.4	-0.4	0.6
Medication: Atenolol	0.4	0.6	1.3	-0.2	0.8	-1.2	0.5
Had other major operations	0.4	0.5	1.2	-0.9	-1.1	-0.1	0.1
Mouth/teeth dental problems	0.4	0.6	0.8	-0.4	-0.7	0.9	-0.8
Medication: Lansoprazole	0.4	0.4	1.1	-0.6	-0.5	-0.1	1.0
Worry too long after embarrassment	0.4	0.7	1.9	0.1	0.0	1.0	1.4
Neck or shoulder pain in last month	0.4	0.6	2.4	-0.0	1.6	-0.3	0.1
Supplements: Vitamin C	0.4	0.5	1.6	-0.4	-0.5	-1.3	-0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.2	1.1	-0.8	-0.2
Loneliness, isolation	0.4	0.6	0.7	-0.9	-0.7	0.6	0.8
Wears glasses or contact lenses	0.4	0.4	1.2	-0.6	-0.0	-0.3	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.2	-1.1	-0.1	-0.5	0.6
Average weekly beer plus cider intake	0.4	0.6	0.8	-0.5	-0.7	0.9	0.8
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	-0.3	-0.6	-0.9	-0.8
Neuroticism (Nagel 2018)	0.3	0.6	1.6	0.8	1.2	-0.4	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-1.0	-0.4	-0.7	0.0
Primary Biliary Cirrhosis	0.3	0.5	1.0	-0.7	0.1	0.6	1.0
Hand grip strength (left)	0.3	0.8	1.7	-1.3	-0.9	0.8	-0.2
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.1	-0.1	-0.8	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	0.1	-0.8	-0.9	-1.2
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	-0.9	-0.5	0.5	0.2
Forced vital capacity (FVC)	0.3	1.1	1.4	0.9	1.2	1.0	-1.0
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.5	1.2	-0.4	0.2	-0.7
Peak expiratory flow (PEF)	0.3	0.6	2.0	0.2	1.4	0.1	-0.7
Gout (self-reported)	0.3	0.5	1.2	1.1	-0.1	-0.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.2	0.7	0.9	-0.5
Birth weight	0.3	0.6	2.5	0.1	0.1	-1.6	0.2
Comparative body size at age 10	0.3	0.9	1.2	-1.1	-0.3	-1.0	1.0
Number of full brothers	0.3	0.4	0.9	-0.9	0.7	0.4	0.1
Qualifications: College or University degree	0.3	0.8	1.5	-0.6	-1.1	1.2	0.5
Eye problems/disorders: None of the above	0.3	0.3	0.6	0.6	0.3	0.8	-0.6
Angina (self-reported)	0.3	0.3	1.1	-0.3	-0.2	-0.4	1.1
Pulse rate, automated reading	0.3	1.1	2.5	-0.4	-1.6	-1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.7	-0.6	0.1	1.3	-0.4
Mineral and other dietary supplements	0.3	0.5	0.8	-0.8	-0.9	0.7	0.1
Asthma (self-reported)	0.3	0.5	0.9	0.4	0.9	0.7	-0.8
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	-1.1	-0.2	-0.8	-0.0
High cholesterol (Self-reported)	0.3	0.6	1.3	-0.4	0.1	-0.9	1.1
Number of operations (self-reported)	0.3	0.4	1.3	0.2	0.3	-1.1	-0.5
Irritability	0.3	0.6	1.1	0.9	-0.3	-0.6	-1.0
Commuting to job workplace: Cycle	0.3	0.4	0.7	0.8	0.8	0.3	-0.2
Heart disease (siblings)	0.3	0.4	1.0	0.2	0.7	-1.0	-0.3
Bipolar Disorder (2018)	0.2	0.3	1.0	0.0	-1.0	-0.5	0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	0.0	-1.1	-0.7	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.4	1.2	0.1	0.7	-0.3
Schizophrenia (2014)	0.2	0.5	1.5	0.0	-1.2	-0.6	0.0
Blood Eosinophil Count	0.2	1.3	2.4	-1.4	-0.5	-0.7	1.5
Heel T-Score	0.2	1.4	3.3	1.8	0.5	0.5	-1.4
Waist Hip Ratio (WHR)	0.2	0.8	1.9	-0.2	1.4	-1.1	-0.2
Respiratory disease	0.2	0.4	0.9	-0.9	0.3	0.7	-0.4
Neuroticism	0.2	0.5	1.1	-0.3	0.7	-0.5	1.1
Angina	0.2	0.3	1.1	-0.2	-0.2	-0.1	1.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.5	0.1	-0.8	0.3
Qualifications: None of the above	0.2	0.4	1.2	0.1	0.6	-1.1	-0.3
Pain all over the body in last month	0.2	0.2	0.5	-0.1	0.6	-0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	0.2	0.2	0.8	0.3
Neuroticism score	0.2	0.4	0.9	-0.0	0.2	-0.9	0.9
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	0.6	0.2	0.1
Number of live births	0.2	0.3	0.8	-0.9	-0.5	-0.3	0.3
Asthma	0.2	0.4	0.5	0.2	0.6	0.7	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.8	-0.5	-0.6	-0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.4	0.5	0.2	0.8
Blood clot in the leg (DVT)	0.2	0.3	0.8	0.6	0.2	0.0	-0.9
Glaucoma (self-reported)	0.2	0.3	0.8	-0.2	0.5	-0.9	0.3
Forced vital capacity (FVC), Best measure	0.2	0.6	2.1	0.1	0.6	1.4	-0.4
Emphysema/chronic bronchitis	0.2	0.3	0.7	-0.4	-0.4	-0.8	0.0
Medication: Seretide 50 evohaler	0.2	0.3	0.8	-0.1	-0.3	0.9	-0.4
Mean time to correctly identify matches	0.2	0.4	0.8	-0.6	-0.0	0.6	0.9
Long-standing illness, disability or infirmity	0.2	0.2	0.8	0.1	0.3	-0.3	-0.9
Eye problems/disorders: Cataract	0.2	0.3	0.5	-0.1	0.5	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.5	0.6	-0.2	0.2	-0.7
Medication: Lisinopril	0.2	0.3	0.6	-0.8	0.1	-0.2	0.7
Age started oral contraceptive pill	0.2	0.3	0.7	-0.1	-0.4	0.6	0.8
Unable to work because of sickness or disability	0.2	0.3	0.6	0.1	0.8	0.2	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	0.6	0.5	0.3	-0.7
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	0.1	0.2	0.7	0.8
Depression (Nagel 2018)	0.1	0.2	0.3	0.3	0.3	0.6	0.3
Crohns Disease (2012)	0.1	0.1	0.4	0.0	-0.4	-0.6	0.0
HDL Cholesterol	0.1	0.2	0.8	0.3	0.4	0.9	0.0
Ulcerative Colitis	0.1	0.1	0.4	0.0	-0.7	0.3	0.0
Systolic Blood Pressure	0.1	0.5	1.2	-1.1	-0.7	-0.3	0.5
Hand grip strength (right)	0.1	0.3	0.7	0.3	0.4	-0.5	-0.8
Supplements: Glucosamine	0.1	0.1	0.2	0.5	0.4	-0.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.5	0.4	-0.6	0.0
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.4	0.5	-0.6	0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	0.2	0.2	0.1	-0.7
Had menopause	0.1	0.1	0.4	0.2	-0.6	-0.0	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.0	-0.7	-0.2	-0.7
Medication: Simvastatin	0.1	0.1	0.3	0.3	0.3	0.5	0.4
Happiness	0.1	0.1	0.2	-0.2	0.4	0.3	0.1
Lung cancer (father)	0.1	0.2	0.5	-0.7	-0.3	-0.3	-0.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.4	-0.6	0.1	-0.2	0.2
Breastfed as a baby	0.1	0.2	0.5	0.0	0.2	-0.7	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.1	-0.3	0.3	-0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.8	-0.9	-0.1	-0.1	-0.1
Pulse wave peak to peak time	0.1	0.1	0.2	0.3	-0.5	0.3	0.1
Osteoporosis (self-reported)	0.1	0.1	0.2	0.2	0.5	-0.3	-0.2
Diastolic blood pressure, automated reading	0.1	0.3	0.9	0.0	0.9	0.3	-0.6
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.1	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.1	0.2	0.2	0.4	-0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.3	0.7	-0.7	0.0	-0.1	0.8
Hair Pigment	0.0	0.5	1.1	-1.1	0.1	0.1	0.9
Sensitivity / hurt feelings	0.0	0.0	0.2	0.0	-0.0	0.0	0.4
Fed-up feelings	0.0	0.1	0.2	-0.1	-0.2	-0.4	0.0
Depression (self-reported)	0.0	0.1	0.2	-0.1	-0.1	-0.4	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.3	0.2	0.3	-0.5	-0.2

Hub : Genes

RAB11FIP3

Models

Trait associations