TWAS hub - DET1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1000	0.0380	3.5e-03	0.063	NA	0.041	NA	0.050	1.7e-05	NA	4.4e-04	NA	1.3e-04
2	GTEx	Muscle Skeletal	0.0766	0.0260	5.4e-04	0.081	NA	0.067	NA	0.079	2.2e-08	NA	3.8e-07	NA	3.5e-08
3	YFS	Blood	0.1652	0.0237	0.0e+00	0.201	0.162	0.190	0.195	0.198	1.5e-63	1.8e-50	6.0e-60	1.6e-61	1.4e-62
4	TCGA	Breast Invasive Carcinoma	0.0185	0.0113	5.5e-04	0.016	0.013	0.011	NA	0.011	2.0e-04	8.6e-04	1.8e-03	NA	1.7e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0235	0.0144	2.9e-03	0.022	0.016	0.011	NA	0.009	1.5e-03	6.2e-03	1.7e-02	NA	2.7e-02
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0680	0.0420	3.3e-03	0.029	0.027	0.010	NA	0.025	8.4e-03	1.1e-02	7.9e-02	NA	1.3e-02
7	TCGA	Pancreatic Adenocarcinoma	0.0560	0.0350	4.3e-03	0.088	0.065	0.083	NA	0.083	1.6e-04	1.1e-03	2.5e-04	NA	2.4e-04
8	TCGA	Prostate Adenocarcinoma	0.0553	0.0329	9.9e-04	-0.001	0.021	0.023	NA	0.011	4.2e-01	2.8e-03	1.6e-03	NA	2.3e-02
9	TCGA	Thyroid Carcinoma	0.0730	0.0300	2.5e-07	0.013	0.044	0.032	NA	0.025	1.6e-02	3.9e-05	3.8e-04	NA	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Relative age of first facial hair	10.5	21.6	55.2	-2.9	4.1	-7.4	-6.5	-3.3	-2.9	-4.0	-4.6	-3.9
Relative age voice broke	10.5	16.0	28.6	-3.1	3.8	-5.2	-5.3	-3.5	-3.2	-3.8	-4.3	-3.1
Bipolar Disorder (2011)	6.6	6.4	10.2	0.0	0.0	-1.5	-3.0	-3.1	-3.1	-3.0	-3.2	-2.9
LDL Cholesterol	6.3	10.0	15.2	3.3	-3.2	0.9	2.7	3.7	3.3	3.2	3.2	3.9
Age when periods started (menarche)	5.8	14.0	52.7	-0.4	1.9	-7.3	-5.2	-1.2	-2.1	-1.8	-4.6	-3.5
Triglycerides	4.6	7.5	11.2	3.1	-3.1	1.2	2.5	3.3	2.5	3.1	2.2	2.9
Ulcerative Colitis	4.4	6.4	9.8	-3.1	3.1	-2.8	-3.0	-2.5	-1.0	-3.1	-1.8	-1.4
Ulcerative Colitis (UC)	4.2	8.0	11.7	-3.4	3.4	-2.5	-3.4	-3.1	-1.7	-3.4	-2.2	-1.5
Supplements: Fish oil (including cod liver oil)	4.1	5.3	8.0	2.1	-2.4	2.6	2.8	2.4	1.8	2.3	2.0	2.2
Bipolar Disorder (2018)	4.0	6.4	8.9	-2.0	2.3	-2.1	-2.6	-2.6	-2.5	-2.4	-3.0	-3.0
Pulse rate	3.8	6.3	9.6	-1.9	2.5	-2.2	-2.8	-2.5	-2.3	-2.5	-3.1	-2.7
Hypothyroidism (self reported)	3.7	8.5	11.6	3.4	-3.4	2.7	3.2	3.2	1.7	3.3	1.4	3.1
Tinnitus: Yes, now most or all of the time	3.7	4.3	7.4	-2.1	2.2	-0.3	-1.8	-2.6	-2.7	-2.2	-1.5	-2.2
Supplements: Calcium	3.7	4.0	11.6	-1.3	1.8	-3.4	-2.6	-1.6	-1.2	-1.7	-2.1	-1.3
Osteoporosis (self-reported)	3.6	4.5	10.4	0.7	-1.2	1.2	2.2	1.5	2.9	1.2	3.1	3.2
Mood swings	3.5	6.3	8.2	2.9	-2.5	1.2	2.8	2.9	2.7	2.4	2.5	2.4
Eye problems/disorders: Cataract	3.5	4.0	6.3	2.5	-1.9	1.4	2.0	2.5	2.1	1.8	1.5	2.1
Number of treatments/medications taken	3.4	6.2	8.9	2.4	-2.7	2.5	3.0	2.5	1.8	2.8	2.6	1.8
Medication: Levothyroxine sodium	3.2	5.4	7.8	2.5	-2.8	2.7	2.6	2.4	0.9	2.8	0.6	2.6
Pain all over the body in last month	3.2	3.5	5.8	2.2	-2.4	1.6	2.3	2.0	1.1	2.4	-0.5	1.2
Worrier / anxious feelings	3.1	5.8	8.9	3.0	-2.3	1.3	2.5	2.8	2.6	2.3	2.1	2.2
Family relationship satisfaction	3.1	3.8	6.3	-2.1	2.5	-1.8	-2.3	-2.3	-1.5	-2.5	-0.8	-1.0
Lung cancer (father)	2.9	3.4	4.6	1.8	-1.9	1.4	1.9	2.1	1.7	1.9	2.0	1.7
Forced expiratory volume in 1-second (FEV1), predicted	2.9	6.0	9.7	-3.1	2.8	-2.4	-2.4	-3.0	-1.5	-2.8	-1.8	-1.7
Alzheimer’s Disease (in father)	2.8	3.0	6.2	-1.5	1.8	-2.5	-2.1	-1.7	-0.9	-1.7	-1.7	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.3	6.2	1.3	-1.6	1.4	1.9	1.7	2.2	1.7	1.8	2.5
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	6.1	-2.5	2.2	-1.2	-1.8	-2.2	-1.3	-2.1	-0.4	-0.8
Hearing difficulty/problems: Yes	2.7	4.1	9.0	-2.3	1.8	0.7	-1.1	-2.7	-3.0	-1.6	-1.5	-2.4
Length of working week for main job	2.7	3.0	5.3	-2.1	2.3	-2.3	-2.1	-1.4	0.2	-2.2	-0.4	0.0
Mineral and other dietary supplements	2.7	3.6	6.2	-2.2	2.3	-2.1	-2.5	-1.9	-1.1	-2.3	-0.4	-1.1
Hair/balding pattern: Pattern 2	2.6	3.3	4.9	1.7	-1.9	2.1	2.2	1.8	1.1	1.9	1.4	1.9
Medication: Ramipril	2.6	3.4	10.7	1.0	-1.0	0.2	1.7	1.9	3.3	1.1	2.4	2.0
High cholesterol (Self-reported)	2.6	4.7	7.7	1.8	-2.1	2.2	2.4	2.2	1.9	2.1	2.8	1.7
Risk taking	2.6	3.8	7.2	-2.2	2.3	-2.6	-2.7	-1.9	-0.8	-2.4	-0.1	-0.7
Irritable Bowel Disease (IBD)	2.5	5.9	10.0	-3.2	3.0	-2.5	-2.8	-2.7	-1.1	-3.0	-1.5	-1.1
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	4.3	-1.5	1.8	-2.0	-2.1	-1.6	-1.1	-1.9	-2.1	-1.3
Chronotype (morning person)	2.4	5.5	9.7	-3.1	2.5	-1.4	-2.8	-2.6	-2.6	-2.4	-1.1	-1.8
Bipolar Disorder or Schizophrenia	2.3	5.6	9.5	-1.8	2.0	-2.4	-2.5	-2.5	-2.5	-2.1	-2.3	-3.1
Systolic blood pressure, automated reading	2.3	6.6	12.0	1.9	-2.3	3.5	3.0	2.1	1.3	2.3	3.2	2.8
Medication: Simvastatin	2.3	3.3	5.9	1.3	-1.8	2.4	2.3	1.7	1.4	1.9	1.9	1.1
Lupus	2.2	3.4	6.7	-1.5	1.8	-2.6	-2.5	-1.5	-1.6	-1.8	-1.5	-1.2
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	7.1	2.2	-2.3	2.2	2.2	2.2	1.0	2.2	1.3	2.7
Allergy	2.1	4.8	10.9	1.1	-1.2	0.7	1.9	1.9	3.1	1.2	3.3	3.2
Illnesses of mother	2.1	2.6	5.0	-1.3	1.7	-2.2	-2.1	-1.4	-0.9	-1.6	-1.3	-1.4
Eye problems/disorders: Glaucoma	2.1	2.5	3.9	-1.9	1.9	-1.1	-2.0	-1.7	-1.4	-1.9	-0.3	-1.2
Worry (Nagel 2018)	2.0	4.3	7.2	2.7	-2.3	1.7	2.5	2.3	2.0	2.2	1.2	1.3
Neuroticism score	2.0	4.1	5.8	2.3	-2.0	1.4	2.4	2.2	1.9	1.9	1.8	2.2
Average weekly spirits intake	1.9	2.3	5.5	1.2	-1.2	1.5	1.8	1.5	1.6	1.2	2.3	1.0
Sensitivity / hurt feelings	1.9	3.3	4.7	2.0	-1.9	1.1	2.1	2.0	1.8	2.0	0.7	2.2
Wheeze or whistling in the chest in last year	1.9	3.3	7.5	-1.6	1.5	0.3	-1.4	-2.1	-2.7	-1.5	-2.0	-2.2
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	6.2	-2.0	1.7	-2.5	-2.3	-1.8	-1.4	-1.6	-0.7	-0.9
Miserableness	1.9	3.2	4.5	2.1	-1.9	1.3	2.1	2.0	1.6	1.8	1.7	1.5
Standing height	1.8	17.7	41.1	-3.8	4.6	-6.4	-5.2	-3.8	-1.6	-4.5	-2.9	-3.1
Father’s age at death	1.7	2.3	3.8	-1.2	1.6	-1.8	-1.7	-1.4	-1.1	-1.6	-1.9	-1.2
Birth weight of first child	1.7	3.0	4.0	1.9	-2.0	1.1	1.8	2.0	2.0	2.0	0.9	1.6
Medication: Aspirin	1.7	2.2	6.7	0.4	-0.8	1.0	1.7	1.1	2.0	0.8	2.6	1.6
Number of self-reported non-cancer illnesses	1.7	3.0	6.8	1.8	-2.0	2.6	2.0	1.6	0.3	2.1	1.4	0.6
Neuroticism (Nagel 2018)	1.6	3.7	5.0	2.2	-2.0	1.2	2.2	2.1	2.0	1.9	1.8	1.6
Breast Cancer	1.6	4.0	5.7	-2.3	2.3	-2.3	-2.4	-2.1	-1.1	-2.3	-0.5	-1.6
High blood pressure (siblings)	1.6	2.2	4.6	1.1	-1.3	1.4	1.8	1.3	1.6	1.4	2.1	1.2
Medication: Aspirin	1.6	2.1	6.9	0.6	-0.8	0.7	1.6	1.2	2.1	0.8	2.6	1.3
Height	1.5	28.7	65.8	-5.1	5.8	-8.1	-6.7	-4.9	-1.7	-5.8	-3.9	-3.5
Medication for hormone replacement therapy	1.5	1.6	5.3	-1.0	0.7	1.4	-0.3	-1.4	-2.3	-0.7	-1.4	-1.2
Sitting height	1.5	10.4	16.0	-3.9	4.0	-3.0	-3.4	-3.8	-1.6	-4.0	-2.2	-2.1
Illnesses of siblings	1.5	2.1	3.6	-0.9	1.4	-1.8	-1.9	-1.3	-1.6	-1.4	-1.6	-1.0
Depression (self-reported)	1.5	1.8	5.6	2.4	-1.6	-0.7	0.6	1.9	1.1	1.5	0.1	0.6
Exposure to tobacco smoke at home	1.5	1.7	4.4	-1.1	1.1	0.8	-0.6	-1.6	-1.7	-1.1	-0.6	-2.1
Pulse wave reflection index	1.5	1.8	3.9	0.6	-1.1	1.7	1.6	1.0	0.9	1.1	1.6	2.0
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.7	-0.2	0.7	0.1	-0.7	-1.2	-2.2	-0.8	-2.0	-2.4
Hearing aid user	1.5	1.7	2.3	-1.4	1.5	-0.9	-1.3	-1.5	-1.3	-1.4	-0.5	-1.5
Schizophrenia (2014)	1.4	3.1	4.9	-2.2	2.0	-1.6	-1.9	-2.1	-1.4	-2.1	0.0	-1.5
Neuroticism	1.4	3.4	5.8	2.4	-2.1	1.4	2.3	2.0	1.4	1.9	1.3	1.4
Diabetes (father)	1.4	1.7	3.3	-1.1	1.4	-0.4	-1.2	-1.5	-1.3	-1.5	-1.1	-1.8
Hair/balding pattern: Pattern 3	1.4	2.1	3.3	-1.5	1.6	-1.3	-1.8	-1.5	-1.5	-1.6	-0.8	-1.2
Age at last live birth	1.4	2.0	4.1	2.0	-2.0	0.4	1.5	1.7	1.0	2.0	0.2	-0.1
Long-standing illness, disability or infirmity	1.4	2.2	4.7	-1.0	1.4	-0.6	-1.8	-1.4	-2.2	-1.3	-1.9	-1.2
Ever had prostate specific antigen (PSA) test	1.4	1.7	3.8	1.1	-1.5	2.0	2.0	0.9	0.4	1.4	0.7	0.8
Ever had hysterectomy (womb removed)	1.3	1.5	5.0	1.1	-1.4	2.2	1.6	0.7	-0.3	1.4	0.0	0.1
Mouth/teeth dental problems	1.3	1.9	4.4	2.1	-1.6	0.6	1.4	1.9	1.4	1.6	-0.1	0.6
Mouth/teeth dental problems: Dentures	1.3	2.2	5.9	-2.4	1.6	0.5	-0.9	-2.0	-1.4	-1.6	-0.2	-1.1
Breastfed as a baby	1.3	1.7	5.0	0.5	-0.8	1.5	1.4	1.0	1.4	0.8	1.1	2.2
Chest pain or discomfort	1.3	1.9	6.6	1.0	-1.3	2.6	2.0	0.9	0.5	1.3	1.0	0.3
Commuting to job workplace: Public transport	1.3	1.5	3.2	-0.8	1.1	-0.3	-0.9	-1.4	-1.8	-1.0	-1.7	-1.3
Medication: Bendroflumethiazide	1.3	1.9	3.7	1.0	-1.1	0.3	1.2	1.5	1.7	1.2	1.9	1.8
Alcohol drinker status: Never	1.3	1.6	4.8	0.6	-0.8	-0.1	0.7	1.3	1.8	0.9	2.2	1.4
Unable to work because of sickness or disability	1.3	1.7	4.3	1.1	-1.4	2.1	2.0	1.1	1.0	1.3	0.4	0.3
Mean Putamen Volume	1.2	1.4	3.9	0.4	-0.2	0.4	0.9	0.9	1.6	0.3	1.9	2.0
Qualifications: None of the above	1.2	2.5	8.9	-0.2	-0.7	3.0	1.9	0.5	0.7	0.7	2.7	1.0
Medication: Lansoprazole	1.2	1.4	3.2	-1.3	1.4	-1.8	-1.3	-0.9	0.2	-1.4	-0.6	-0.9
Glaucoma (self-reported)	1.2	1.4	2.4	-1.2	1.4	-1.2	-1.5	-1.2	-0.9	-1.4	-0.3	-0.9
Friendships satisfaction	1.2	1.4	2.5	-1.0	1.6	-1.3	-1.2	-1.3	-0.6	-1.6	-0.9	-0.9
Ever taken oral contraceptive pill	1.2	1.4	2.2	-1.5	1.3	-0.7	-1.2	-1.4	-0.6	-1.3	-1.0	-1.2
Average weekly beer plus cider intake	1.2	1.8	3.9	-1.1	1.2	-0.1	-1.1	-1.4	-2.0	-1.2	-1.4	-1.6
Cholesterol lowering medication	1.2	1.7	2.9	1.7	-1.5	1.1	1.3	1.7	0.8	1.5	1.0	0.9
Intelligence (Savage-Jansen 2018)	1.1	3.3	8.3	2.9	-2.4	0.8	1.6	2.1	0.3	2.5	-1.4	0.4
Hayfever, allergic rhinitis or eczema	1.1	2.3	6.2	-0.7	0.9	-0.9	-1.6	-1.3	-2.1	-0.9	-2.5	-1.7
High blood pressure (mother)	1.1	1.6	5.4	1.1	-0.8	-0.1	0.5	1.4	1.3	0.8	1.6	2.3
Medication: Cholesterol lowering	1.1	1.7	4.1	0.5	-1.1	1.7	1.7	0.8	0.8	1.2	2.0	0.9
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	5.9	-0.6	1.2	-2.4	-1.8	-0.6	-0.3	-1.2	-1.6	-0.2
Shortness of breath walking on level ground	1.1	1.4	2.8	-1.7	1.4	0.4	-0.6	-1.5	-0.9	-1.4	0.4	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.6	1.3	-0.8	-1.3	0.2	1.5	1.9	0.8	0.8	0.5
Pulse rate, automated reading	1.1	3.4	5.1	-2.3	1.9	-1.1	-1.7	-2.2	-1.2	-1.9	-2.0	-2.0
Illnesses of father: Heart disease	1.1	1.5	4.1	2.0	-1.5	0.1	1.0	1.7	1.0	1.4	0.0	0.1
Smoking status: Previous	1.1	1.6	2.3	-1.1	1.5	-0.7	-1.2	-1.4	-1.5	-1.4	-1.0	-1.3
Diastolic blood pressure, automated reading	1.1	3.4	4.6	1.6	-1.9	2.1	2.0	1.7	1.0	2.0	1.9	2.1
Fasting Glucose	1.0	1.2	5.1	0.2	1.4	-2.3	-0.8	0.2	1.0	-1.3	0.2	0.1
Taking other prescription medications	1.0	1.5	4.5	1.4	-1.4	2.1	1.3	0.9	-0.5	1.4	0.5	0.1
Supplements: Glucosamine	1.0	1.3	2.3	1.5	-1.5	1.3	1.5	0.9	0.1	1.4	-0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.6	0.3	-0.6	1.6	0.5	-0.4	-1.6	0.6	-1.9	-1.4
Impedance of arm (left)	1.0	4.8	17.8	-1.9	2.2	-4.2	-3.0	-1.4	-0.1	-2.2	-1.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	6.4	0.6	0.4	-1.5	-1.2	-0.4	-1.2	-0.5	-2.5	-1.3
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.1	0.7	-1.0	2.0	1.6	0.6	0.1	1.0	0.8	1.0
Handedness (chirality/laterality): Left-handed	1.0	1.2	6.2	-0.1	0.8	-2.5	-1.5	-0.3	-0.1	-0.8	-0.7	0.1
Average weekly champagne plus white wine intake	1.0	1.4	2.5	1.0	-1.3	1.3	1.3	1.1	0.7	1.3	0.9	1.6
Heart disease (siblings)	1.0	1.2	2.4	0.2	-0.8	1.4	1.1	0.9	1.2	0.8	1.6	1.2
Systolic Blood Pressure	0.9	4.3	7.2	1.3	-2.0	2.7	2.4	1.7	1.3	2.1	2.6	2.0
Hearing difficulty/problems with background noise	0.9	1.4	3.2	-1.0	0.9	1.1	-0.4	-1.3	-1.8	-0.9	-0.8	-1.7
Fluid intelligence score	0.9	1.8	3.8	2.0	-1.7	0.6	0.9	1.5	-0.2	1.8	-1.6	0.3
Trunk fat-free mass	0.9	5.0	9.1	-1.8	2.1	-2.0	-2.3	-2.4	-2.0	-2.1	-2.1	-3.0
Asthma	0.9	1.9	7.6	-0.3	0.6	0.1	-0.6	-0.9	-1.4	-0.7	-2.3	-2.7
Trunk predicted mass	0.9	5.1	9.3	-1.8	2.2	-2.0	-2.3	-2.4	-2.1	-2.1	-2.0	-3.1
Commuting to job workplace: Walk	0.9	1.0	2.6	0.7	-1.1	0.1	0.7	1.2	1.1	1.1	0.0	1.6
Asthma (self-reported)	0.9	1.9	6.7	-0.5	0.7	-0.2	-0.8	-1.0	-1.4	-0.8	-2.3	-2.6
Schizophrenia vs Biploar Disorder	0.8	1.0	4.0	-0.8	0.6	-1.1	-0.4	0.3	1.6	-0.5	0.0	2.0
Crohns Disease (2017)	0.8	1.7	3.5	-1.9	1.6	-1.5	-1.4	-1.4	-0.5	-1.6	-0.6	-0.5
Prostate Cancer	0.8	1.2	1.8	-0.7	1.1	-0.8	-1.3	-1.1	-1.1	-1.1	-0.8	-1.3
Neuroticism (2016)	0.8	1.1	3.4	0.8	-0.7	0.3	1.3	1.1	1.9	0.6	0.5	1.4
Leg fat-free mass (left)	0.8	4.3	7.9	-1.8	2.1	-2.8	-2.5	-1.9	-1.2	-2.0	-1.3	-2.3
Medication: Atenolol	0.8	1.0	3.4	0.3	-0.0	0.7	0.9	0.5	1.0	0.1	1.9	1.6
Leg predicted mass (left)	0.8	4.3	7.7	-1.8	2.1	-2.8	-2.5	-1.9	-1.3	-2.0	-1.3	-2.4
Noisy workplace	0.8	1.0	2.6	-1.6	0.8	1.3	0.1	-1.0	-0.5	-0.8	1.4	-0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	6.3	0.4	0.3	-1.1	-1.0	-0.3	-1.2	-0.4	-2.5	-0.9
Mean time to correctly identify matches	0.8	1.4	3.8	-1.1	1.1	0.5	-0.7	-1.5	-1.9	-1.1	-0.7	-1.4
Number of full sisters	0.8	1.0	3.4	-1.8	1.4	0.3	-0.4	-1.3	-0.3	-1.3	0.3	0.3
Whole body fat-free mass	0.8	4.7	7.6	-1.8	2.1	-2.3	-2.4	-2.3	-1.8	-2.1	-1.8	-2.8
Qualifications: nursing, teaching	0.8	1.2	4.4	-0.3	0.9	-0.2	-0.8	-0.9	-1.3	-0.9	-2.1	-1.2
Breast cancer (self-reported)	0.8	1.0	2.0	0.8	-0.8	1.0	1.2	0.9	0.9	0.8	1.4	0.9
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.1	-0.7	1.2	-1.4	-0.9	-0.4	0.7	-1.2	0.8	1.0
Vascular/heart problems diagnosed by doctor	0.8	2.0	4.3	-0.9	1.2	-1.1	-1.4	-1.4	-1.6	-1.3	-2.1	-1.6
Heart attack/myocardial infarction (self-reported)	0.8	1.1	4.0	0.0	-0.4	0.6	0.9	0.5	1.0	0.5	2.0	1.7
Depressed Affect (Nagel 2018)	0.7	1.5	3.2	1.4	-0.9	0.4	1.1	1.3	1.3	0.8	1.8	1.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.3	1.7	-1.6	0.6	1.0	1.1	0.1	1.7	-1.8	-0.3
Respiratory disease	0.7	1.5	3.7	-0.9	1.3	-1.1	-1.2	-1.1	-0.8	-1.4	-0.9	-1.9
Lung FVC	0.7	3.5	7.7	1.7	-2.3	2.8	2.3	1.6	0.8	2.3	1.3	0.8
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.6	-0.2	-0.1	1.6	0.5	-0.7	-1.3	0.1	-0.8	-1.5
Severe depression (siblings)	0.7	0.8	1.6	1.2	-1.2	1.0	1.1	0.8	0.0	1.3	-0.0	0.3
Hand grip strength (right)	0.7	1.9	4.9	-0.7	1.1	-0.7	-1.2	-1.2	-1.1	-1.1	-2.0	-2.2
Heart attack	0.7	0.9	3.7	0.0	-0.4	0.4	0.7	0.5	1.0	0.4	1.9	1.5
Impedance of arm (right)	0.7	3.1	12.3	-1.5	1.8	-3.5	-2.4	-0.9	0.2	-1.7	-0.4	0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	6.6	0.1	0.6	-1.6	-1.2	-0.6	-1.1	-0.5	-2.6	-0.7
Tense / ‘highly strung’	0.7	1.1	1.9	1.0	-1.4	0.8	1.3	1.1	0.7	1.3	0.5	1.2
Number of children fathered	0.7	0.8	2.0	-1.2	0.4	1.4	0.2	-1.1	-0.9	-0.4	-0.6	-1.1
Health satisfaction	0.7	0.9	2.2	-1.5	1.3	-0.2	-0.7	-0.9	0.3	-1.3	0.8	0.6
Leg fat-free mass (right)	0.7	3.7	6.9	-1.8	1.9	-2.6	-2.4	-1.9	-1.2	-1.9	-1.2	-2.1
Whole body water mass	0.7	3.8	6.2	-1.6	1.9	-2.1	-2.2	-2.0	-1.6	-1.9	-1.6	-2.5
Leg predicted mass (right)	0.7	3.6	7.0	-1.7	1.9	-2.6	-2.3	-1.8	-1.1	-1.8	-1.1	-2.0
Basal metabolic rate	0.7	3.9	5.5	-1.7	2.0	-2.3	-2.3	-2.0	-1.5	-1.9	-1.4	-2.3
Fractured/broken bones in last 5 years	0.7	0.9	2.3	0.8	-0.5	-0.7	0.3	1.1	0.9	0.6	1.2	1.5
Ever depressed for a whole week	0.7	0.8	2.0	-0.5	0.7	-1.1	-1.4	-0.8	-1.2	-0.7	-1.0	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.4	-1.0	0.7	-0.2	-0.7	-1.2	-1.6	-0.7	-0.8	-0.6
Crohns Disease (2012)	0.6	1.0	2.4	-1.1	1.0	-1.6	-0.7	-0.2	1.3	-0.9	0.6	0.9
HDL Cholesterol	0.6	1.0	1.9	-1.2	1.3	0.2	-0.8	-1.4	-1.0	-1.4	-0.3	-0.7
Heel T-Score	0.6	5.1	21.4	2.2	-2.4	4.6	2.6	1.2	-0.9	2.2	0.4	-0.2
Allergy or Eczema	0.6	1.5	2.8	-0.7	0.9	-1.2	-1.6	-1.0	-1.7	-0.9	-1.5	-1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	-1.2	1.3	-0.3	-0.7	-0.9	-0.2	-1.3	0.4	-0.1
Medication: Metformin	0.6	0.8	1.6	-1.1	1.1	-1.3	-1.0	-0.6	0.6	-1.1	-0.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.1	-1.5	1.1	-0.5	-0.8	-1.0	-0.3	-1.2	-0.5	-0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.6	0.0	0.2	1.6	0.1	-0.5	-1.6	-0.2	-0.5	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	2.2	-1.1	1.5	-0.8	-0.9	-0.8	0.4	-1.5	-0.2	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.8	0.7	-0.5	-0.7	0.3	1.0	1.7	0.4	0.5	1.0
Alcohol intake frequency.	0.6	1.4	2.5	-1.3	1.1	-0.9	-1.4	-1.2	-1.3	-1.0	-0.1	-1.6
Loneliness, isolation	0.6	0.9	1.9	-1.3	1.3	0.5	-0.3	-1.2	-0.4	-1.4	0.2	-0.7
Medication for cholesterol	0.6	0.9	3.6	-0.9	1.0	-1.9	-1.0	-0.6	0.5	-1.0	0.3	0.1
Mother’s age at death	0.6	0.8	3.5	-0.2	0.6	-0.6	-0.9	-0.6	-1.0	-0.6	-1.9	-0.4
Number of operations (self-reported)	0.6	0.9	4.1	-0.1	0.0	0.6	-0.2	-0.7	-2.0	-0.0	-1.2	-1.4
Pain experienced in last month	0.6	0.9	1.8	1.2	-1.3	0.2	0.9	1.2	0.9	1.3	-0.4	0.4
Alcohol drinker status: Previous	0.6	0.7	1.8	-1.3	1.0	0.7	-0.4	-1.2	-0.8	-1.0	0.2	-0.3
Schizophrenia (2018)	0.5	1.1	2.5	-0.6	0.7	-1.4	-1.1	-1.1	-1.1	-0.8	-0.5	-1.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	-0.6	1.0	-0.6	-1.3	-0.7	-0.7	-1.0	-0.5	-0.7
Rheumatoid Arthritis	0.5	0.7	1.6	0.6	-0.7	0.9	1.2	0.7	1.3	0.6	0.3	0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.6	-0.7	0.8	-1.3	-0.8	-0.3	0.5	-0.8	-0.1	0.7
Pack years adult smoking proportion	0.5	0.7	2.6	-0.7	0.4	-0.4	0.3	-0.0	1.6	-0.4	1.5	0.7
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.6	-0.4	-0.3	1.2	0.3	-0.4	-1.2	0.4	-1.2	-0.4
Multivitamins +/- minerals	0.5	0.6	1.7	-0.7	0.3	0.2	-0.4	-0.8	-0.9	-0.3	-1.3	-1.1
Trunk fat mass	0.5	1.9	8.5	-1.1	1.3	-2.9	-1.9	-0.8	-0.2	-1.2	0.2	-0.6
Nervous feelings	0.5	0.9	2.6	1.1	-1.1	1.6	1.2	0.5	-0.1	1.0	-0.0	-0.0
Had other major operations	0.5	0.6	2.1	-0.3	0.3	1.1	-0.1	-0.6	-1.4	-0.3	-0.9	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.5	1.3	-1.1	1.6	1.2	1.0	0.4	1.0	0.9	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	-1.2	0.5	0.0	-0.4	-1.1	-1.2	-0.4	-0.7	-0.7
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-1.2	0.9	-0.4	-0.6	-1.1	-0.8	-0.8	-0.2	-0.4
Hair/balding pattern: Pattern 4	0.5	1.3	2.6	-1.1	1.2	0.9	-0.4	-1.6	-1.3	-1.1	-0.8	-1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.3	1.2	-0.9	0.1	0.5	0.9	0.6	0.8	0.8	0.8
Medication: Omeprazole	0.5	0.6	1.8	-1.1	0.7	0.4	-0.3	-1.0	-1.3	-0.6	-0.2	0.6
Medication: Seretide 50 evohaler	0.5	0.5	2.0	-0.8	0.7	-0.1	-0.4	-0.8	-0.6	-0.7	-0.1	-1.4
Back pain experienced in last month	0.5	0.8	1.3	-1.1	1.1	-0.8	-1.2	-0.9	-0.6	-1.1	0.2	-0.5
Medication: Blood pressure	0.5	0.9	1.7	1.1	-1.2	0.2	0.8	1.3	0.9	1.3	0.4	0.4
Irritability	0.5	0.9	2.0	1.4	-0.6	0.5	1.2	1.0	1.0	0.6	0.4	1.3
Commuting to job workplace: Cycle	0.5	0.6	1.5	-0.6	0.5	0.6	-0.4	-0.8	-1.2	-0.5	-0.6	-1.2
Alzheimer’s Disease (in mother)	0.4	0.4	1.2	1.1	-0.7	0.8	0.2	0.8	-0.1	0.7	0.5	0.1
Reaction Time	0.4	0.7	2.5	-0.8	0.7	0.7	-0.3	-1.1	-1.6	-0.6	-0.2	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	3.1	1.0	-0.9	1.8	0.8	0.4	-0.7	0.9	-0.2	-0.5
Past tobacco smoking	0.4	0.8	1.4	0.7	-0.9	0.6	0.7	1.0	1.1	0.8	1.0	1.2
Alcohol usually taken with meals	0.4	0.7	2.0	1.3	-0.8	-0.8	0.3	0.8	0.4	0.7	-1.4	0.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	-0.4	0.5	-0.8	-1.2	-0.6	-0.9	-0.4	-0.4	-0.1
Weight	0.4	1.9	5.3	-1.1	1.4	-2.3	-1.8	-1.1	-0.7	-1.3	-0.4	-1.4
Time employed in main current job	0.4	0.4	1.1	1.1	-0.8	0.5	0.6	0.8	0.5	0.7	0.2	0.0
Alcohol intake versus 10 years previously	0.4	0.6	2.8	-0.6	0.6	-1.7	-1.2	-0.2	-0.1	-0.6	0.7	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.6	-1.0	1.2	-0.6	-0.9	-0.7	-0.0	-1.3	-0.1	0.2
Falls in the last year	0.4	0.5	2.0	0.1	-0.1	1.3	0.2	-0.1	-0.9	0.1	-1.4	-0.4
Medication: Paracetamol	0.4	0.7	1.6	0.5	-1.1	1.1	1.3	0.5	0.3	1.0	0.7	-0.2
Birth weight	0.4	0.8	2.0	0.4	0.4	-1.4	-1.1	-0.1	-0.7	-0.4	-1.3	-1.0
Arm fat-free mass (right)	0.4	1.8	4.1	-1.0	1.3	-1.4	-1.3	-1.4	-1.1	-1.3	-1.1	-2.0
Medication for pain relief, constipation, heartburn	0.4	0.7	1.4	-0.7	1.0	-1.0	-1.2	-0.6	-0.1	-1.0	-0.8	-0.4
Medication: Blood pressure	0.4	0.8	3.5	-0.2	-0.1	0.5	0.7	0.3	1.4	0.1	1.9	0.8
Migraine (self-reported)	0.4	0.6	1.9	0.5	-0.8	1.4	0.6	0.0	-0.7	0.8	-0.5	-0.6
Medication: Allopurinol	0.4	0.5	1.4	-1.2	0.8	0.0	-0.6	-1.0	-0.9	-0.7	0.0	0.1
Heart disease (mother)	0.4	0.5	1.6	0.8	-0.6	1.0	0.8	0.2	-0.2	0.5	-0.4	-1.3
Whole body fat mass	0.4	1.5	5.4	-1.1	1.3	-2.3	-1.6	-0.8	-0.3	-1.1	0.3	-0.6
Arm predicted mass (right)	0.4	2.1	4.2	-1.1	1.4	-1.5	-1.5	-1.5	-1.1	-1.4	-1.2	-2.1
Suffer from ‘nerves’	0.4	0.6	1.0	0.9	-0.7	0.8	1.0	0.6	0.4	0.6	0.6	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.7	-0.9	0.3	1.3	0.3	-0.6	-0.6	-0.3	0.8	0.3
Medication: Atorvastatin	0.4	0.5	1.2	-1.1	0.6	0.1	-0.4	-0.8	-0.6	-0.6	1.1	0.3
Pack years of smoking	0.4	0.6	2.5	-0.8	0.4	-0.2	0.3	-0.2	1.3	-0.4	1.6	0.6
Impedance of whole body	0.4	2.0	7.7	-1.3	1.4	-2.8	-1.9	-0.7	0.4	-1.4	-0.3	0.6
Ovarian Cancer	0.3	0.5	2.2	0.2	0.4	-1.5	-1.0	-0.2	-0.3	-0.5	0.2	-0.5
Age at First Birth	0.3	0.4	1.1	1.1	-0.7	-0.4	0.1	0.5	-0.1	0.7	-0.1	-1.0
HbA1C	0.3	0.4	1.9	0.2	0.1	-1.4	-0.4	0.6	0.7	0.0	0.0	0.7
Primary Biliary Cirrhosis	0.3	0.5	0.9	0.9	-0.9	0.2	0.7	0.8	0.5	0.8	0.8	0.3
Blood Eosinophil Count	0.3	2.3	5.3	1.8	-2.0	2.3	1.6	1.2	-0.4	1.9	-0.3	-0.3
Smoking Status	0.3	0.7	1.3	-1.1	0.9	-1.2	-0.8	-0.8	-0.1	-0.8	-0.5	-0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.3	-0.6	0.7	-0.4	-0.3	-0.1	1.0	-0.7	1.1	0.7
Lung FEV1/FVC ratio	0.3	1.3	2.4	-0.7	1.1	-1.6	-1.2	-0.9	-1.0	-1.0	-1.4	-1.1
Angina	0.3	0.4	0.9	0.3	-0.8	0.9	0.8	0.5	0.3	0.8	0.4	0.2
Supplements: Zinc	0.3	0.4	0.9	-0.2	0.2	-0.7	-0.7	-0.4	-0.5	-0.2	-0.9	-0.9
Trunk fat percentage	0.3	1.0	5.7	-0.6	0.7	-2.4	-1.2	-0.1	0.4	-0.5	0.8	0.3
Qualifications: CSEs or equivalent	0.3	0.4	1.3	0.2	-0.0	-1.2	-0.8	0.4	0.6	0.1	0.7	0.6
High blood pressure	0.3	0.8	3.0	0.2	-0.4	0.5	0.6	0.7	1.1	0.5	1.7	1.1
Had menopause	0.3	0.4	1.3	1.1	-0.5	0.5	0.4	0.8	-0.1	0.5	-0.1	0.7
Financial difficulties in last 2 years	0.3	0.4	1.0	-0.4	0.4	-1.0	-0.5	-0.4	0.1	-0.4	-0.8	-1.0
Diabetes (self-reported)	0.3	0.5	1.1	-0.8	0.8	-0.1	-0.2	-0.3	0.8	-0.7	1.0	0.8
Number of live births	0.3	0.5	1.1	-0.4	0.8	-0.1	-0.7	-0.7	-0.7	-0.9	-0.3	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.6	0.7	-0.5	0.0	0.2	0.1	-0.8	0.4	-1.3	-0.2
Prospective memory result	0.3	0.4	0.9	-1.0	0.6	0.6	0.4	-0.8	0.0	-0.7	-0.3	-0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.1	0.2	0.1	-0.9	-0.2	0.5	1.0	-0.1	0.7	0.1
Gout (self-reported)	0.3	0.4	1.7	-0.3	-0.4	0.8	0.5	0.1	-0.2	0.4	1.3	0.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.5	-0.4	-0.0	1.2	0.6	-0.5	-0.5	0.1	0.1	-0.6
Comparative body size at age 10	0.3	0.8	2.6	1.1	-0.8	-1.6	-0.3	1.1	0.6	0.8	-0.7	0.5
Number of full brothers	0.3	0.4	1.3	0.9	-0.7	-0.3	-0.1	0.4	-0.4	0.6	-0.7	-1.1
Age at first live birth	0.3	0.6	1.9	-0.2	0.2	-0.8	-0.6	-0.6	-0.8	-0.1	-1.4	-1.1
Qualifications: College or University degree	0.3	0.9	4.8	0.9	-0.1	-2.2	-0.6	0.3	0.3	0.0	-1.5	-0.2
Emphysema/chronic bronchitis	0.3	0.3	1.2	-0.8	0.4	-0.2	-0.3	-0.7	-0.7	-0.3	-0.1	-1.1
Overall health rating	0.3	0.7	2.6	0.2	-0.7	1.6	1.2	0.5	0.3	0.8	0.8	0.6
Had major operations	0.3	0.3	1.5	0.1	-0.4	1.2	0.5	-0.0	-0.8	0.3	0.6	-0.3
Leg pain on walking	0.3	0.3	0.9	-0.6	0.9	-0.2	-0.3	-0.4	0.5	-0.9	0.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.3	0.1	-0.3	0.4	0.5	0.5	0.7	0.4	0.9	1.1
Knee pain experienced in last month	0.3	0.4	0.7	-0.8	0.8	-0.7	-0.7	-0.7	-0.3	-0.8	0.1	-0.4
Hypertension (Self-reported)	0.3	0.7	2.2	0.2	-0.5	0.7	0.7	0.7	1.0	0.6	1.5	1.0
Average weekly red wine intake	0.3	0.4	0.8	0.8	-0.3	-0.9	-0.0	0.7	0.6	0.3	-0.8	0.6
Ever had bowel cancer screening	0.3	0.3	0.8	0.4	-0.3	0.6	0.0	0.1	-0.8	0.3	0.8	-0.9
Diabetes diagnosed by doctor	0.3	0.5	1.5	-0.9	0.7	0.2	-0.0	-0.3	0.7	-0.7	1.2	0.4
Medication: Gliclazide	0.3	0.3	1.2	-0.5	0.4	-0.4	0.0	0.1	0.9	-0.3	0.1	1.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	0.3	-0.8	0.4	0.6	0.4	0.1	0.8	0.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.1	0.7	-1.0	0.9	0.6	0.3	-0.5	1.0	-0.7	-0.8
Ever smoked	0.3	0.6	1.0	-0.7	0.7	-0.7	-0.7	-0.9	-1.0	-0.6	-1.0	-0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	0.8	-0.6	-1.1	-0.2	0.6	-0.2	0.6	-0.6	-0.6
Arm predicted mass (left)	0.3	1.6	2.9	-1.2	1.3	-0.9	-1.3	-1.5	-1.3	-1.3	-0.6	-1.7
Major Depression (MDD)	0.2	0.2	0.7	0.3	-0.3	-0.7	0.2	0.6	0.9	0.4	-0.1	0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.6	-0.7	-0.1	0.4	0.6	0.5	0.7	0.3	-0.7
Waist Hip Ratio (WHR)	0.2	0.8	2.3	0.6	-0.8	0.3	0.9	1.0	1.5	0.8	0.2	1.3
Cardiovascular Disease	0.2	0.7	1.2	0.7	-1.0	0.7	0.8	0.9	0.9	1.0	1.1	0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.5	-0.3	0.3	-0.2	-0.6	-0.3	-0.6	-0.2	-1.2	-0.3
Vitamin and mineral supplements	0.2	0.2	0.5	-0.2	0.6	-0.6	-0.7	-0.2	-0.2	-0.5	0.6	0.1
Diabetes (mother)	0.2	0.2	0.6	-0.3	0.5	-0.8	-0.4	-0.1	0.5	-0.5	0.7	0.1
Maternal smoking around birth	0.2	0.2	0.8	-0.6	0.3	0.9	0.2	-0.5	-0.5	-0.2	0.1	-0.6
Fed-up feelings	0.2	0.4	0.6	0.8	-0.8	0.7	0.8	0.6	0.2	0.7	0.7	0.5
Serious illness, injury or assault to yourself	0.2	0.3	1.1	-0.6	0.5	-1.0	-0.7	-0.2	0.2	-0.4	0.3	-0.1
Stomach or abdominal pain in last month	0.2	0.3	0.5	-0.5	0.6	0.7	-0.0	-0.5	-0.4	-0.7	0.5	0.4
Number of incorrect matches in round	0.2	0.4	1.0	0.1	0.3	1.0	0.2	-0.4	-0.7	-0.3	0.9	-0.9
Hip circumference	0.2	0.8	2.8	-0.8	0.9	-1.7	-1.0	-0.7	-0.3	-0.8	0.2	-0.9
Happiness	0.2	0.3	0.8	-0.1	0.5	-0.2	0.1	-0.1	0.8	-0.5	0.9	0.6
Arm fat mass (right)	0.2	0.9	2.7	-1.0	1.0	-1.6	-1.3	-0.7	-0.5	-0.9	0.3	-0.4
Peak expiratory flow (PEF)	0.2	0.4	0.9	0.6	-0.4	-0.3	-0.2	-0.0	-0.8	0.4	-0.9	-0.9
Blood clot in the leg (DVT)	0.2	0.2	1.0	0.0	0.2	-1.0	-0.7	-0.2	-0.3	-0.2	0.1	-0.5
Body fat percentage	0.2	0.6	3.0	-0.4	0.5	-1.7	-0.8	0.0	0.3	-0.3	1.0	0.3
Exposure to tobacco smoke outside home	0.2	0.3	1.2	-1.1	0.7	0.3	0.1	-0.7	0.3	-0.6	-0.4	-0.2
Worry too long after embarrassment	0.2	0.4	1.8	0.5	-0.2	-0.3	0.4	0.5	0.8	0.2	1.3	0.2
Pulse wave peak to peak time	0.2	0.3	1.0	1.0	-0.5	-0.0	0.2	0.8	0.6	0.5	0.0	0.2
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.8	0.1	0.4	0.2	-0.6	-0.4	-0.0	-0.7	-0.5
Medication: Ibuprofen	0.2	0.2	0.6	0.2	0.0	-0.6	-0.4	-0.1	-0.7	-0.0	-0.8	-0.3
Comparative height size at age 10	0.2	0.9	1.9	-0.6	0.1	1.3	1.4	-0.1	0.9	-0.0	1.3	1.1
Arm fat percentage (left)	0.2	0.7	3.3	-0.7	0.7	-1.8	-1.1	-0.3	0.0	-0.6	0.6	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	0.3	-0.7	0.2	0.3	0.5	-0.0	0.8	-0.0	-0.5
Arm fat mass (left)	0.2	0.7	2.3	-0.8	0.8	-1.5	-1.1	-0.6	-0.4	-0.7	0.2	-0.6
Financial situation satisfaction	0.2	0.3	1.0	-0.5	0.5	-0.9	-0.2	-0.1	1.0	-0.5	-0.1	0.1
Illnesses of father: High blood pressure	0.2	0.3	0.9	-0.0	0.1	-0.1	0.3	0.3	0.9	0.0	0.8	0.8
Arm fat-free mass (left)	0.2	1.1	2.4	-0.9	1.0	-0.7	-1.0	-1.3	-1.1	-1.0	-0.7	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	0.1	0.1	-0.9	-0.7	-0.2	-0.4	-0.1	-0.3	-0.7
Depression (Nagel 2018)	0.1	0.1	0.2	-0.4	0.2	-0.2	-0.3	-0.4	0.1	-0.4	-0.2	0.1
Coronary Artery Disease (CAD)	0.1	0.2	0.6	-0.3	0.3	-0.1	-0.0	0.0	0.4	-0.3	0.8	0.6
Blood Red Count	0.1	1.3	3.2	-0.8	0.9	-0.5	-0.8	-1.1	-1.1	-0.9	-1.8	-1.6
Blood White Count	0.1	0.9	1.7	1.0	-1.2	1.3	1.1	0.9	0.3	1.3	0.2	-0.0
Hair Pigment	0.1	2.2	4.2	0.8	-1.4	1.8	1.7	1.3	0.8	1.4	1.4	2.1
Tanning	0.1	1.5	3.0	-1.7	1.1	1.5	-0.4	-1.4	-1.1	-1.2	1.4	-0.4
Hand grip strength (left)	0.1	0.2	1.5	0.1	-0.1	0.0	-0.1	-0.1	-0.3	0.1	-0.7	-1.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.7	-0.3	0.7	-0.1	-0.1	-0.3	0.3	-0.8	-0.5	0.4
Medication: Co-codamol	0.1	0.1	0.3	-0.1	0.3	-0.3	-0.4	-0.1	-0.1	-0.4	-0.5	0.1
Impedance of leg (right)	0.1	0.5	1.5	-0.7	0.8	-1.2	-1.0	-0.4	0.2	-0.8	-0.4	0.4
Townsend deprivation index at recruitment	0.1	0.1	0.4	-0.3	0.0	0.2	-0.0	-0.3	-0.6	0.0	-0.6	0.3
Current tobacco smoking	0.1	0.1	0.6	-0.8	0.2	0.3	0.1	-0.3	0.3	-0.1	0.1	0.1
Average weekly fortified wine intake	0.1	0.1	0.4	0.5	-0.5	-0.3	-0.0	0.3	-0.1	0.5	-0.1	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.1	0.2	-0.0	-0.2	-0.3	-0.3	-0.2	-0.4	-0.5
Chronic bronchitis/emphysema (father)	0.1	0.2	0.5	0.3	-0.4	0.7	0.3	0.2	-0.4	0.5	-0.1	0.1
Body mass index (BMI)	0.1	0.4	1.1	0.6	-0.7	0.6	0.7	0.6	-0.0	0.8	1.0	0.0
Impedance of leg (left)	0.1	0.4	1.8	-0.3	0.4	-1.0	-0.4	0.1	0.7	-0.4	0.1	1.3
Arm fat percentage (right)	0.1	0.5	2.2	-0.6	0.5	-1.5	-0.9	-0.1	0.1	-0.4	0.9	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.9	0.5	-0.3	-0.6	-0.3	0.1	-0.2	0.3	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.4	0.2	-0.2	-0.8	-0.3	-0.1	-0.2	0.2	-1.2	-0.4
Loud music exposure frequency	0.1	0.2	0.4	0.1	-0.4	0.6	0.6	0.2	0.1	0.4	0.6	-0.2
Headache pain in last month	0.1	0.1	0.3	-0.6	0.1	0.5	0.3	-0.2	0.2	-0.1	0.5	0.5
Medication: Amlodipine	0.1	0.2	0.7	-0.4	0.5	-0.4	-0.1	-0.1	0.8	-0.5	0.3	0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	1.8	-0.1	0.0	-1.0	-0.6	-0.3	-0.3	-0.0	-1.3	-0.7
Neck or shoulder pain in last month	0.1	0.2	0.7	0.4	0.0	0.6	-0.1	-0.1	-0.8	-0.0	-0.2	-0.4
Angina (self-reported)	0.1	0.1	0.3	0.1	-0.5	0.6	0.5	0.4	0.2	0.6	-0.0	0.0
Leg fat mass (right)	0.1	0.5	0.8	-0.8	0.8	-0.9	-0.8	-0.6	-0.4	-0.6	0.5	-0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.6	0.5	-0.1	0.0	-0.2	-0.2	-0.6	0.1	-0.8	-0.5
Supplements: Vitamin C	0.1	0.1	0.1	0.1	-0.3	-0.1	0.3	0.2	0.4	0.4	-0.1	-0.2
Illnesses of siblings: Diabetes	0.1	0.2	0.6	-0.3	0.1	-0.5	-0.0	0.3	0.8	0.0	0.6	-0.0
Osteoarthritis (self-reported)	0.1	0.2	0.5	0.4	-0.3	-0.6	-0.2	0.5	0.3	0.3	0.7	0.4
Wears glasses or contact lenses	0.1	0.1	0.3	-0.1	0.2	0.1	0.2	-0.3	-0.1	-0.1	-0.3	0.6
Medication: Paracetamol	0.1	0.2	0.4	0.1	-0.4	0.3	0.7	0.2	0.5	0.4	0.6	-0.0
Medication: Lisinopril	0.1	0.1	0.5	-0.1	-0.2	0.7	0.3	0.1	0.0	0.3	-0.2	0.1
Leg fat percentage (left)	0.1	0.5	1.7	0.5	-0.6	0.4	0.6	0.7	0.3	0.7	1.3	0.5
Age started oral contraceptive pill	0.1	0.2	0.7	0.4	-0.4	-0.3	0.1	0.1	0.0	0.3	-0.3	-0.8
Myopia	0.1	0.2	0.3	0.6	-0.5	0.1	0.3	0.5	0.5	0.5	0.3	-0.5
Leg fat mass (left)	0.1	0.3	0.8	-0.7	0.6	-0.9	-0.7	-0.4	-0.2	-0.5	0.7	-0.2
Blood Platelet Count	0.0	0.4	1.0	-0.0	0.2	-1.0	-0.8	-0.2	-0.6	-0.1	-1.0	-0.6
BMI	0.0	0.2	0.8	-0.1	0.2	-0.1	-0.3	-0.3	-0.9	-0.1	0.3	-0.9
Waist circumference	0.0	0.0	0.2	-0.2	0.2	-0.4	-0.1	-0.1	0.1	-0.1	0.2	-0.2
Forced vital capacity (FVC)	0.0	0.1	0.7	0.2	-0.2	-0.5	-0.3	-0.0	-0.1	0.2	-0.8	-0.5
Leg fat percentage (right)	0.0	0.1	0.8	0.2	-0.3	0.3	0.2	0.3	-0.0	0.4	0.9	-0.1
Smoking status: Current	0.0	0.1	0.5	-0.7	0.2	-0.1	-0.1	-0.3	0.3	-0.1	0.0	-0.0
Guilty feelings	0.0	0.1	0.2	-0.0	-0.2	0.4	0.3	0.1	-0.2	0.3	0.2	0.3

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