Hub : Genes

DET1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1000 0.0380 3.5e-03 0.063 NA 0.041 NA 0.050 1.7e-05 NA 4.4e-04 NA 1.3e-04
2 GTEx Muscle Skeletal 0.0766 0.0260 5.4e-04 0.081 NA 0.067 NA 0.079 2.2e-08 NA 3.8e-07 NA 3.5e-08
3 YFS Blood 0.1652 0.0237 0.0e+00 0.201 0.162 0.190 0.195 0.198 1.5e-63 1.8e-50 6.0e-60 1.6e-61 1.4e-62
4 TCGA Breast Invasive Carcinoma 0.0185 0.0113 5.5e-04 0.016 0.013 0.011 NA 0.011 2.0e-04 8.6e-04 1.8e-03 NA 1.7e-03
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0235 0.0144 2.9e-03 0.022 0.016 0.011 NA 0.009 1.5e-03 6.2e-03 1.7e-02 NA 2.7e-02
6 TCGA Kidney Renal Papillary Cell Carcinoma 0.0680 0.0420 3.3e-03 0.029 0.027 0.010 NA 0.025 8.4e-03 1.1e-02 7.9e-02 NA 1.3e-02
7 TCGA Pancreatic Adenocarcinoma 0.0560 0.0350 4.3e-03 0.088 0.065 0.083 NA 0.083 1.6e-04 1.1e-03 2.5e-04 NA 2.4e-04
8 TCGA Prostate Adenocarcinoma 0.0553 0.0329 9.9e-04 -0.001 0.021 0.023 NA 0.011 4.2e-01 2.8e-03 1.6e-03 NA 2.3e-02
9 TCGA Thyroid Carcinoma 0.0730 0.0300 2.5e-07 0.013 0.044 0.032 NA 0.025 1.6e-02 3.9e-05 3.8e-04 NA 1.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 4.0 6.4 8.9 -2.0 2.3 -2.1 -2.6 -2.6 -2.5 -2.4 -3.0 -3.0
Bipolar Disorder or Schizophrenia 2.3 5.6 9.5 -1.8 2.0 -2.4 -2.5 -2.5 -2.5 -2.1 -2.3 -3.1
Depressed Affect (Nagel 2018) 0.7 1.5 3.2 1.4 -0.9 0.4 1.1 1.3 1.3 0.8 1.8 1.2
Depression (Nagel 2018) 0.1 0.1 0.2 -0.4 0.2 -0.2 -0.3 -0.4 0.1 -0.4 -0.2 0.1
Intelligence (Savage-Jansen 2018) 1.1 3.3 8.3 2.9 -2.4 0.8 1.6 2.1 0.3 2.5 -1.4 0.4
Neuroticism (Nagel 2018) 1.6 3.7 5.0 2.2 -2.0 1.2 2.2 2.1 2.0 1.9 1.8 1.6
Schizophrenia (2018) 0.5 1.1 2.5 -0.6 0.7 -1.4 -1.1 -1.1 -1.1 -0.8 -0.5 -1.6
Schizophrenia vs Biploar Disorder 0.8 1.0 4.0 -0.8 0.6 -1.1 -0.4 0.3 1.6 -0.5 0.0 2.0
Worry (Nagel 2018) 2.0 4.3 7.2 2.7 -2.3 1.7 2.5 2.3 2.0 2.2 1.2 1.3
Alzheimer’s Disease (in mother) 0.4 0.4 1.2 1.1 -0.7 0.8 0.2 0.8 -0.1 0.7 0.5 0.1
Alzheimer’s Disease (in father) 2.8 3.0 6.2 -1.5 1.8 -2.5 -2.1 -1.7 -0.9 -1.7 -1.7 -1.4
Alzheimer’s Disease (including proxy) 0.5 0.7 1.6 -0.6 1.0 -0.6 -1.3 -0.7 -0.7 -1.0 -0.5 -0.7
Crohns Disease (2017) 0.8 1.7 3.5 -1.9 1.6 -1.5 -1.4 -1.4 -0.5 -1.6 -0.6 -0.5
Irritable Bowel Disease (IBD) 2.5 5.9 10.0 -3.2 3.0 -2.5 -2.8 -2.7 -1.1 -3.0 -1.5 -1.1
Ulcerative Colitis (UC) 4.2 8.0 11.7 -3.4 3.4 -2.5 -3.4 -3.1 -1.7 -3.4 -2.2 -1.5
Major Depression (MDD) 0.2 0.2 0.7 0.3 -0.3 -0.7 0.2 0.6 0.9 0.4 -0.1 0.5
Reaction Time 0.4 0.7 2.5 -0.8 0.7 0.7 -0.3 -1.1 -1.6 -0.6 -0.2 -1.1
Verbal and Numeric Reasoning (VNR) 0.7 1.6 3.3 1.7 -1.6 0.6 1.0 1.1 0.1 1.7 -1.8 -0.3
Breast Cancer 1.6 4.0 5.7 -2.3 2.3 -2.3 -2.4 -2.1 -1.1 -2.3 -0.5 -1.6
Ovarian Cancer 0.3 0.5 2.2 0.2 0.4 -1.5 -1.0 -0.2 -0.3 -0.5 0.2 -0.5
Prostate Cancer 0.8 1.2 1.8 -0.7 1.1 -0.8 -1.3 -1.1 -1.1 -1.1 -0.8 -1.3
Age at First Birth 0.3 0.4 1.1 1.1 -0.7 -0.4 0.1 0.5 -0.1 0.7 -0.1 -1.0
Bipolar Disorder (2011) 6.6 6.4 10.2 0.0 0.0 -1.5 -3.0 -3.1 -3.1 -3.0 -3.2 -2.9
Body Mass Index (BMI) (2010) 0.2 0.3 0.5 0.6 -0.7 -0.1 0.4 0.6 0.5 0.7 0.3 -0.7
Coronary Artery Disease (CAD) 0.1 0.2 0.6 -0.3 0.3 -0.1 -0.0 0.0 0.4 -0.3 0.8 0.6
Crohns Disease (2012) 0.6 1.0 2.4 -1.1 1.0 -1.6 -0.7 -0.2 1.3 -0.9 0.6 0.9
Mean Putamen Volume 1.2 1.4 3.9 0.4 -0.2 0.4 0.9 0.9 1.6 0.3 1.9 2.0
Fasting Glucose 1.0 1.2 5.1 0.2 1.4 -2.3 -0.8 0.2 1.0 -1.3 0.2 0.1
HbA1C 0.3 0.4 1.9 0.2 0.1 -1.4 -0.4 0.6 0.7 0.0 0.0 0.7
HDL Cholesterol 0.6 1.0 1.9 -1.2 1.3 0.2 -0.8 -1.4 -1.0 -1.4 -0.3 -0.7
LDL Cholesterol 6.3 10.0 15.2 3.3 -3.2 0.9 2.7 3.7 3.3 3.2 3.2 3.9
Lupus 2.2 3.4 6.7 -1.5 1.8 -2.6 -2.5 -1.5 -1.6 -1.8 -1.5 -1.2
Neuroticism (2016) 0.8 1.1 3.4 0.8 -0.7 0.3 1.3 1.1 1.9 0.6 0.5 1.4
Primary Biliary Cirrhosis 0.3 0.5 0.9 0.9 -0.9 0.2 0.7 0.8 0.5 0.8 0.8 0.3
Rheumatoid Arthritis 0.5 0.7 1.6 0.6 -0.7 0.9 1.2 0.7 1.3 0.6 0.3 0.6
Schizophrenia (2014) 1.4 3.1 4.9 -2.2 2.0 -1.6 -1.9 -2.1 -1.4 -2.1 0.0 -1.5
Triglycerides 4.6 7.5 11.2 3.1 -3.1 1.2 2.5 3.3 2.5 3.1 2.2 2.9
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.6 -0.7 0.8 -1.3 -0.8 -0.3 0.5 -0.8 -0.1 0.7
Ulcerative Colitis 4.4 6.4 9.8 -3.1 3.1 -2.8 -3.0 -2.5 -1.0 -3.1 -1.8 -1.4
Blood Eosinophil Count 0.3 2.3 5.3 1.8 -2.0 2.3 1.6 1.2 -0.4 1.9 -0.3 -0.3
Blood Platelet Count 0.0 0.4 1.0 -0.0 0.2 -1.0 -0.8 -0.2 -0.6 -0.1 -1.0 -0.6
Blood Red Count 0.1 1.3 3.2 -0.8 0.9 -0.5 -0.8 -1.1 -1.1 -0.9 -1.8 -1.6
Blood White Count 0.1 0.9 1.7 1.0 -1.2 1.3 1.1 0.9 0.3 1.3 0.2 -0.0
Heel T-Score 0.6 5.1 21.4 2.2 -2.4 4.6 2.6 1.2 -0.9 2.2 0.4 -0.2
BMI 0.0 0.2 0.8 -0.1 0.2 -0.1 -0.3 -0.3 -0.9 -0.1 0.3 -0.9
Height 1.5 28.7 65.8 -5.1 5.8 -8.1 -6.7 -4.9 -1.7 -5.8 -3.9 -3.5
Waist Hip Ratio (WHR) 0.2 0.8 2.3 0.6 -0.8 0.3 0.9 1.0 1.5 0.8 0.2 1.3
Systolic Blood Pressure 0.9 4.3 7.2 1.3 -2.0 2.7 2.4 1.7 1.3 2.1 2.6 2.0
Smoking Status 0.3 0.7 1.3 -1.1 0.9 -1.2 -0.8 -0.8 -0.1 -0.8 -0.5 -0.7
Allergy or Eczema 0.6 1.5 2.8 -0.7 0.9 -1.2 -1.6 -1.0 -1.7 -0.9 -1.5 -1.1
Cardiovascular Disease 0.2 0.7 1.2 0.7 -1.0 0.7 0.8 0.9 0.9 1.0 1.1 0.6
Hypothyroidism (self reported) 3.7 8.5 11.6 3.4 -3.4 2.7 3.2 3.2 1.7 3.3 1.4 3.1
Respiratory disease 0.7 1.5 3.7 -0.9 1.3 -1.1 -1.2 -1.1 -0.8 -1.4 -0.9 -1.9
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.3 -0.6 0.7 -0.4 -0.3 -0.1 1.0 -0.7 1.1 0.7
Lung FEV1/FVC ratio 0.3 1.3 2.4 -0.7 1.1 -1.6 -1.2 -0.9 -1.0 -1.0 -1.4 -1.1
Lung FVC 0.7 3.5 7.7 1.7 -2.3 2.8 2.3 1.6 0.8 2.3 1.3 0.8
Neuroticism 1.4 3.4 5.8 2.4 -2.1 1.4 2.3 2.0 1.4 1.9 1.3 1.4
Chronotype (morning person) 2.4 5.5 9.7 -3.1 2.5 -1.4 -2.8 -2.6 -2.6 -2.4 -1.1 -1.8
Hair Pigment 0.1 2.2 4.2 0.8 -1.4 1.8 1.7 1.3 0.8 1.4 1.4 2.1
Tanning 0.1 1.5 3.0 -1.7 1.1 1.5 -0.4 -1.4 -1.1 -1.2 1.4 -0.4
Hand grip strength (left) 0.1 0.2 1.5 0.1 -0.1 0.0 -0.1 -0.1 -0.3 0.1 -0.7 -1.2
Number of treatments/medications taken 3.4 6.2 8.9 2.4 -2.7 2.5 3.0 2.5 1.8 2.8 2.6 1.8
Average weekly spirits intake 1.9 2.3 5.5 1.2 -1.2 1.5 1.8 1.5 1.6 1.2 2.3 1.0
Sensitivity / hurt feelings 1.9 3.3 4.7 2.0 -1.9 1.1 2.1 2.0 1.8 2.0 0.7 2.2
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.7 -0.3 0.7 -0.1 -0.1 -0.3 0.3 -0.8 -0.5 0.4
Hearing difficulty/problems: Yes 2.7 4.1 9.0 -2.3 1.8 0.7 -1.1 -2.7 -3.0 -1.6 -1.5 -2.4
Relative age of first facial hair 10.5 21.6 55.2 -2.9 4.1 -7.4 -6.5 -3.3 -2.9 -4.0 -4.6 -3.9
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.5 -0.3 0.3 -0.2 -0.6 -0.3 -0.6 -0.2 -1.2 -0.3
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.6 -0.2 -0.1 1.6 0.5 -0.7 -1.3 0.1 -0.8 -1.5
Ever had hysterectomy (womb removed) 1.3 1.5 5.0 1.1 -1.4 2.2 1.6 0.7 -0.3 1.4 0.0 0.1
Systolic blood pressure, automated reading 2.3 6.6 12.0 1.9 -2.3 3.5 3.0 2.1 1.3 2.3 3.2 2.8
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.7 -1.2 1.3 -0.3 -0.7 -0.9 -0.2 -1.3 0.4 -0.1
Angina 0.3 0.4 0.9 0.3 -0.8 0.9 0.8 0.5 0.3 0.8 0.4 0.2
Medication for hormone replacement therapy 1.5 1.6 5.3 -1.0 0.7 1.4 -0.3 -1.4 -2.3 -0.7 -1.4 -1.2
Vitamin and mineral supplements 0.2 0.2 0.5 -0.2 0.6 -0.6 -0.7 -0.2 -0.2 -0.5 0.6 0.1
Supplements: Zinc 0.3 0.4 0.9 -0.2 0.2 -0.7 -0.7 -0.4 -0.5 -0.2 -0.9 -0.9
Medication: Co-codamol 0.1 0.1 0.3 -0.1 0.3 -0.3 -0.4 -0.1 -0.1 -0.4 -0.5 0.1
Medication: Metformin 0.6 0.8 1.6 -1.1 1.1 -1.3 -1.0 -0.6 0.6 -1.1 -0.0 0.3
Diabetes (father) 1.4 1.7 3.3 -1.1 1.4 -0.4 -1.2 -1.5 -1.3 -1.5 -1.1 -1.8
Diabetes (mother) 0.2 0.2 0.6 -0.3 0.5 -0.8 -0.4 -0.1 0.5 -0.5 0.7 0.1
Severe depression (siblings) 0.7 0.8 1.6 1.2 -1.2 1.0 1.1 0.8 0.0 1.3 -0.0 0.3
Pack years adult smoking proportion 0.5 0.7 2.6 -0.7 0.4 -0.4 0.3 -0.0 1.6 -0.4 1.5 0.7
Impedance of leg (right) 0.1 0.5 1.5 -0.7 0.8 -1.2 -1.0 -0.4 0.2 -0.8 -0.4 0.4
Leg fat-free mass (left) 0.8 4.3 7.9 -1.8 2.1 -2.8 -2.5 -1.9 -1.2 -2.0 -1.3 -2.3
Trunk fat percentage 0.3 1.0 5.7 -0.6 0.7 -2.4 -1.2 -0.1 0.4 -0.5 0.8 0.3
Hand grip strength (right) 0.7 1.9 4.9 -0.7 1.1 -0.7 -1.2 -1.2 -1.1 -1.1 -2.0 -2.2
Townsend deprivation index at recruitment 0.1 0.1 0.4 -0.3 0.0 0.2 -0.0 -0.3 -0.6 0.0 -0.6 0.3
Current tobacco smoking 0.1 0.1 0.6 -0.8 0.2 0.3 0.1 -0.3 0.3 -0.1 0.1 0.1
Average weekly fortified wine intake 0.1 0.1 0.4 0.5 -0.5 -0.3 -0.0 0.3 -0.1 0.5 -0.1 -0.6
Maternal smoking around birth 0.2 0.2 0.8 -0.6 0.3 0.9 0.2 -0.5 -0.5 -0.2 0.1 -0.6
Fed-up feelings 0.2 0.4 0.6 0.8 -0.8 0.7 0.8 0.6 0.2 0.7 0.7 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.1 -1.5 1.1 -0.5 -0.8 -1.0 -0.3 -1.2 -0.5 -0.3
Relative age voice broke 10.5 16.0 28.6 -3.1 3.8 -5.2 -5.3 -3.5 -3.2 -3.8 -4.3 -3.1
Taking other prescription medications 1.0 1.5 4.5 1.4 -1.4 2.1 1.3 0.9 -0.5 1.4 0.5 0.1
Age when periods started (menarche) 5.8 14.0 52.7 -0.4 1.9 -7.3 -5.2 -1.2 -2.1 -1.8 -4.6 -3.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.6 -0.4 -0.3 1.2 0.3 -0.4 -1.2 0.4 -1.2 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 3.1 1.0 -0.9 1.8 0.8 0.4 -0.7 0.9 -0.2 -0.5
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 -0.1 0.2 -0.0 -0.2 -0.3 -0.3 -0.2 -0.4 -0.5
Qualifications: CSEs or equivalent 0.3 0.4 1.3 0.2 -0.0 -1.2 -0.8 0.4 0.6 0.1 0.7 0.6
Serious illness, injury or assault to yourself 0.2 0.3 1.1 -0.6 0.5 -1.0 -0.7 -0.2 0.2 -0.4 0.3 -0.1
High blood pressure 0.3 0.8 3.0 0.2 -0.4 0.5 0.6 0.7 1.1 0.5 1.7 1.1
Hayfever, allergic rhinitis or eczema 1.1 2.3 6.2 -0.7 0.9 -0.9 -1.6 -1.3 -2.1 -0.9 -2.5 -1.7
Multivitamins +/- minerals 0.5 0.6 1.7 -0.7 0.3 0.2 -0.4 -0.8 -0.9 -0.3 -1.3 -1.1
Stomach or abdominal pain in last month 0.2 0.3 0.5 -0.5 0.6 0.7 -0.0 -0.5 -0.4 -0.7 0.5 0.4
Supplements: Glucosamine 1.0 1.3 2.3 1.5 -1.5 1.3 1.5 0.9 0.1 1.4 -0.5 -0.2
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.6 0.0 0.2 1.6 0.1 -0.5 -1.6 -0.2 -0.5 -0.7
Medication: Atenolol 0.8 1.0 3.4 0.3 -0.0 0.7 0.9 0.5 1.0 0.1 1.9 1.6
Medication: Levothyroxine sodium 3.2 5.4 7.8 2.5 -2.8 2.7 2.6 2.4 0.9 2.8 0.6 2.6
Sitting height 1.5 10.4 16.0 -3.9 4.0 -3.0 -3.4 -3.8 -1.6 -4.0 -2.2 -2.1
Chronic bronchitis/emphysema (father) 0.1 0.2 0.5 0.3 -0.4 0.7 0.3 0.2 -0.4 0.5 -0.1 0.1
High blood pressure (mother) 1.1 1.6 5.4 1.1 -0.8 -0.1 0.5 1.4 1.3 0.8 1.6 2.3
Body mass index (BMI) 0.1 0.4 1.1 0.6 -0.7 0.6 0.7 0.6 -0.0 0.8 1.0 0.0
Impedance of leg (left) 0.1 0.4 1.8 -0.3 0.4 -1.0 -0.4 0.1 0.7 -0.4 0.1 1.3
Leg predicted mass (left) 0.8 4.3 7.7 -1.8 2.1 -2.8 -2.5 -1.9 -1.3 -2.0 -1.3 -2.4
Trunk fat mass 0.5 1.9 8.5 -1.1 1.3 -2.9 -1.9 -0.8 -0.2 -1.2 0.2 -0.6
Waist circumference 0.0 0.0 0.2 -0.2 0.2 -0.4 -0.1 -0.1 0.1 -0.1 0.2 -0.2
Number of incorrect matches in round 0.2 0.4 1.0 0.1 0.3 1.0 0.2 -0.4 -0.7 -0.3 0.9 -0.9
Past tobacco smoking 0.4 0.8 1.4 0.7 -0.9 0.6 0.7 1.0 1.1 0.8 1.0 1.2
Alcohol usually taken with meals 0.4 0.7 2.0 1.3 -0.8 -0.8 0.3 0.8 0.4 0.7 -1.4 0.0
Nervous feelings 0.5 0.9 2.6 1.1 -1.1 1.6 1.2 0.5 -0.1 1.0 -0.0 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 2.2 -1.1 1.5 -0.8 -0.9 -0.8 0.4 -1.5 -0.2 0.0
Hearing difficulty/problems with background noise 0.9 1.4 3.2 -1.0 0.9 1.1 -0.4 -1.3 -1.8 -0.9 -0.8 -1.7
Hair/balding pattern: Pattern 2 2.6 3.3 4.9 1.7 -1.9 2.1 2.2 1.8 1.1 1.9 1.4 1.9
Had menopause 0.3 0.4 1.3 1.1 -0.5 0.5 0.4 0.8 -0.1 0.5 -0.1 0.7
Had other major operations 0.5 0.6 2.1 -0.3 0.3 1.1 -0.1 -0.6 -1.4 -0.3 -0.9 -0.4
Forced vital capacity (FVC) 0.0 0.1 0.7 0.2 -0.2 -0.5 -0.3 -0.0 -0.1 0.2 -0.8 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.5 1.3 -1.1 1.6 1.2 1.0 0.4 1.0 0.9 0.4
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.4 -0.4 0.5 -0.8 -1.2 -0.6 -0.9 -0.4 -0.4 -0.1
Qualifications: None of the above 1.2 2.5 8.9 -0.2 -0.7 3.0 1.9 0.5 0.7 0.7 2.7 1.0
Financial difficulties in last 2 years 0.3 0.4 1.0 -0.4 0.4 -1.0 -0.5 -0.4 0.1 -0.4 -0.8 -1.0
Mouth/teeth dental problems 1.3 1.9 4.4 2.1 -1.6 0.6 1.4 1.9 1.4 1.6 -0.1 0.6
Heart attack 0.7 0.9 3.7 0.0 -0.4 0.4 0.7 0.5 1.0 0.4 1.9 1.5
Allergy 2.1 4.8 10.9 1.1 -1.2 0.7 1.9 1.9 3.1 1.2 3.3 3.2
Pain all over the body in last month 3.2 3.5 5.8 2.2 -2.4 1.6 2.3 2.0 1.1 2.4 -0.5 1.2
Diabetes (self-reported) 0.3 0.5 1.1 -0.8 0.8 -0.1 -0.2 -0.3 0.8 -0.7 1.0 0.8
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.6 0.3 -0.6 1.6 0.5 -0.4 -1.6 0.6 -1.9 -1.4
Medication: Ramipril 2.6 3.4 10.7 1.0 -1.0 0.2 1.7 1.9 3.3 1.1 2.4 2.0
Medication: Simvastatin 2.3 3.3 5.9 1.3 -1.8 2.4 2.3 1.7 1.4 1.9 1.9 1.1
Fluid intelligence score 0.9 1.8 3.8 2.0 -1.7 0.6 0.9 1.5 -0.2 1.8 -1.6 0.3
Illnesses of siblings 1.5 2.1 3.6 -0.9 1.4 -1.8 -1.9 -1.3 -1.6 -1.4 -1.6 -1.0
Neuroticism score 2.0 4.1 5.8 2.3 -2.0 1.4 2.4 2.2 1.9 1.9 1.8 2.2
Weight 0.4 1.9 5.3 -1.1 1.4 -2.3 -1.8 -1.1 -0.7 -1.3 -0.4 -1.4
Impedance of arm (right) 0.7 3.1 12.3 -1.5 1.8 -3.5 -2.4 -0.9 0.2 -1.7 -0.4 0.3
Arm fat percentage (right) 0.1 0.5 2.2 -0.6 0.5 -1.5 -0.9 -0.1 0.1 -0.4 0.9 0.3
Trunk fat-free mass 0.9 5.0 9.1 -1.8 2.1 -2.0 -2.3 -2.4 -2.0 -2.1 -2.1 -3.0
Hip circumference 0.2 0.8 2.8 -0.8 0.9 -1.7 -1.0 -0.7 -0.3 -0.8 0.2 -0.9
Time employed in main current job 0.4 0.4 1.1 1.1 -0.8 0.5 0.6 0.8 0.5 0.7 0.2 0.0
Alcohol intake versus 10 years previously 0.4 0.6 2.8 -0.6 0.6 -1.7 -1.2 -0.2 -0.1 -0.6 0.7 -0.0
Father’s age at death 1.7 2.3 3.8 -1.2 1.6 -1.8 -1.7 -1.4 -1.1 -1.6 -1.9 -1.2
Worrier / anxious feelings 3.1 5.8 8.9 3.0 -2.3 1.3 2.5 2.8 2.6 2.3 2.1 2.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.6 -1.0 1.2 -0.6 -0.9 -0.7 -0.0 -1.3 -0.1 0.2
Falls in the last year 0.4 0.5 2.0 0.1 -0.1 1.3 0.2 -0.1 -0.9 0.1 -1.4 -0.4
Hair/balding pattern: Pattern 3 1.4 2.1 3.3 -1.5 1.6 -1.3 -1.8 -1.5 -1.5 -1.6 -0.8 -1.2
Number of live births 0.3 0.5 1.1 -0.4 0.8 -0.1 -0.7 -0.7 -0.7 -0.9 -0.3 -1.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.9 0.5 -0.3 -0.6 -0.3 0.1 -0.2 0.3 -0.9 -0.5
Pulse rate 3.8 6.3 9.6 -1.9 2.5 -2.2 -2.8 -2.5 -2.3 -2.5 -3.1 -2.7
Happiness 0.2 0.3 0.8 -0.1 0.5 -0.2 0.1 -0.1 0.8 -0.5 0.9 0.6
Noisy workplace 0.8 1.0 2.6 -1.6 0.8 1.3 0.1 -1.0 -0.5 -0.8 1.4 -0.2
Qualifications: A levels/AS levels or equivalent 0.7 1.5 6.6 0.1 0.6 -1.6 -1.2 -0.6 -1.1 -0.5 -2.6 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.4 -1.2 0.5 0.0 -0.4 -1.1 -1.2 -0.4 -0.7 -0.7
Mouth/teeth dental problems: Dentures 1.3 2.2 5.9 -2.4 1.6 0.5 -0.9 -2.0 -1.4 -1.6 -0.2 -1.1
Asthma 0.9 1.9 7.6 -0.3 0.6 0.1 -0.6 -0.9 -1.4 -0.7 -2.3 -2.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.6 0.7 -0.5 0.0 0.2 0.1 -0.8 0.4 -1.3 -0.2
Medication: Cholesterol lowering 1.1 1.7 4.1 0.5 -1.1 1.7 1.7 0.8 0.8 1.2 2.0 0.9
Depression (self-reported) 1.5 1.8 5.6 2.4 -1.6 -0.7 0.6 1.9 1.1 1.5 0.1 0.6
Medication: Lansoprazole 1.2 1.4 3.2 -1.3 1.4 -1.8 -1.3 -0.9 0.2 -1.4 -0.6 -0.9
Prospective memory result 0.3 0.4 0.9 -1.0 0.6 0.6 0.4 -0.8 0.0 -0.7 -0.3 -0.5
Lung cancer (father) 2.9 3.4 4.6 1.8 -1.9 1.4 1.9 2.1 1.7 1.9 2.0 1.7
Illnesses of mother 2.1 2.6 5.0 -1.3 1.7 -2.2 -2.1 -1.4 -0.9 -1.6 -1.3 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.4 0.2 -0.2 -0.8 -0.3 -0.1 -0.2 0.2 -1.2 -0.4
Pulse wave Arterial Stiffness index 0.5 0.6 1.5 -1.2 0.9 -0.4 -0.6 -1.1 -0.8 -0.8 -0.2 -0.4
Impedance of arm (left) 1.0 4.8 17.8 -1.9 2.2 -4.2 -3.0 -1.4 -0.1 -2.2 -1.1 -0.4
Arm fat mass (right) 0.2 0.9 2.7 -1.0 1.0 -1.6 -1.3 -0.7 -0.5 -0.9 0.3 -0.4
Trunk predicted mass 0.9 5.1 9.3 -1.8 2.2 -2.0 -2.3 -2.4 -2.1 -2.1 -2.0 -3.1
Standing height 1.8 17.7 41.1 -3.8 4.6 -6.4 -5.2 -3.8 -1.6 -4.5 -2.9 -3.1
Length of working week for main job 2.7 3.0 5.3 -2.1 2.3 -2.3 -2.1 -1.4 0.2 -2.2 -0.4 0.0
Exposure to tobacco smoke at home 1.5 1.7 4.4 -1.1 1.1 0.8 -0.6 -1.6 -1.7 -1.1 -0.6 -2.1
Breastfed as a baby 1.3 1.7 5.0 0.5 -0.8 1.5 1.4 1.0 1.4 0.8 1.1 2.2
Tense / ‘highly strung’ 0.7 1.1 1.9 1.0 -1.4 0.8 1.3 1.1 0.7 1.3 0.5 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 6.4 0.6 0.4 -1.5 -1.2 -0.4 -1.2 -0.5 -2.5 -1.3
Hair/balding pattern: Pattern 4 0.5 1.3 2.6 -1.1 1.2 0.9 -0.4 -1.6 -1.3 -1.1 -0.8 -1.3
Birth weight of first child 1.7 3.0 4.0 1.9 -2.0 1.1 1.8 2.0 2.0 2.0 0.9 1.6
Peak expiratory flow (PEF) 0.2 0.4 0.9 0.6 -0.4 -0.3 -0.2 -0.0 -0.8 0.4 -0.9 -0.9
Pulse wave reflection index 1.5 1.8 3.9 0.6 -1.1 1.7 1.6 1.0 0.9 1.1 1.6 2.0
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.1 0.2 0.1 -0.9 -0.2 0.5 1.0 -0.1 0.7 0.1
Loud music exposure frequency 0.1 0.2 0.4 0.1 -0.4 0.6 0.6 0.2 0.1 0.4 0.6 -0.2
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 5.9 -0.6 1.2 -2.4 -1.8 -0.6 -0.3 -1.2 -1.6 -0.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.3 1.2 -0.9 0.1 0.5 0.9 0.6 0.8 0.8 0.8
Blood clot in the leg (DVT) 0.2 0.2 1.0 0.0 0.2 -1.0 -0.7 -0.2 -0.3 -0.2 0.1 -0.5
Medication: Paracetamol 0.4 0.7 1.6 0.5 -1.1 1.1 1.3 0.5 0.3 1.0 0.7 -0.2
Headache pain in last month 0.1 0.1 0.3 -0.6 0.1 0.5 0.3 -0.2 0.2 -0.1 0.5 0.5
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 6.3 0.4 0.3 -1.1 -1.0 -0.3 -1.2 -0.4 -2.5 -0.9
Glaucoma (self-reported) 1.2 1.4 2.4 -1.2 1.4 -1.2 -1.5 -1.2 -0.9 -1.4 -0.3 -0.9
Gout (self-reported) 0.3 0.4 1.7 -0.3 -0.4 0.8 0.5 0.1 -0.2 0.4 1.3 0.7
Hypothyroidism/myxoedema (self-reported) 2.2 4.3 7.1 2.2 -2.3 2.2 2.2 2.2 1.0 2.2 1.3 2.7
Medication: Amlodipine 0.1 0.2 0.7 -0.4 0.5 -0.4 -0.1 -0.1 0.8 -0.5 0.3 0.4
Medication: Ventolin 100micrograms inhaler 1.5 1.9 5.7 -0.2 0.7 0.1 -0.7 -1.2 -2.2 -0.8 -2.0 -2.4
Birth weight 0.4 0.8 2.0 0.4 0.4 -1.4 -1.1 -0.1 -0.7 -0.4 -1.3 -1.0
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.5 -0.4 -0.0 1.2 0.6 -0.5 -0.5 0.1 0.1 -0.6
High blood pressure (siblings) 1.6 2.2 4.6 1.1 -1.3 1.4 1.8 1.3 1.6 1.4 2.1 1.2
Forced vital capacity (FVC), Best measure 0.1 0.4 1.8 -0.1 0.0 -1.0 -0.6 -0.3 -0.3 -0.0 -1.3 -0.7
Body fat percentage 0.2 0.6 3.0 -0.4 0.5 -1.7 -0.8 0.0 0.3 -0.3 1.0 0.3
Leg fat percentage (right) 0.0 0.1 0.8 0.2 -0.3 0.3 0.2 0.3 -0.0 0.4 0.9 -0.1
Arm fat-free mass (right) 0.4 1.8 4.1 -1.0 1.3 -1.4 -1.3 -1.4 -1.1 -1.3 -1.1 -2.0
Exposure to tobacco smoke outside home 0.2 0.3 1.2 -1.1 0.7 0.3 0.1 -0.7 0.3 -0.6 -0.4 -0.2
Comparative body size at age 10 0.3 0.8 2.6 1.1 -0.8 -1.6 -0.3 1.1 0.6 0.8 -0.7 0.5
Number of full brothers 0.3 0.4 1.3 0.9 -0.7 -0.3 -0.1 0.4 -0.4 0.6 -0.7 -1.1
Worry too long after embarrassment 0.2 0.4 1.8 0.5 -0.2 -0.3 0.4 0.5 0.8 0.2 1.3 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.8 0.7 -0.5 -0.7 0.3 1.0 1.7 0.4 0.5 1.0
Wheeze or whistling in the chest in last year 1.9 3.3 7.5 -1.6 1.5 0.3 -1.4 -2.1 -2.7 -1.5 -2.0 -2.2
Number of children fathered 0.7 0.8 2.0 -1.2 0.4 1.4 0.2 -1.1 -0.9 -0.4 -0.6 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 2.8 3.3 6.2 1.3 -1.6 1.4 1.9 1.7 2.2 1.7 1.8 2.5
Age at first live birth 0.3 0.6 1.9 -0.2 0.2 -0.8 -0.6 -0.6 -0.8 -0.1 -1.4 -1.1
Pulse wave peak to peak time 0.2 0.3 1.0 1.0 -0.5 -0.0 0.2 0.8 0.6 0.5 0.0 0.2
Health satisfaction 0.7 0.9 2.2 -1.5 1.3 -0.2 -0.7 -0.9 0.3 -1.3 0.8 0.6
Shortness of breath walking on level ground 1.1 1.4 2.8 -1.7 1.4 0.4 -0.6 -1.5 -0.9 -1.4 0.4 -1.2
Qualifications: College or University degree 0.3 0.9 4.8 0.9 -0.1 -2.2 -0.6 0.3 0.3 0.0 -1.5 -0.2
Eye problems/disorders: None of the above 0.2 0.2 0.6 -0.8 0.1 0.4 0.2 -0.6 -0.4 -0.0 -0.7 -0.5
Mouth/teeth dental problems: Loose teeth 1.0 1.2 4.1 0.7 -1.0 2.0 1.6 0.6 0.1 1.0 0.8 1.0
Emphysema/chronic bronchitis 0.3 0.3 1.2 -0.8 0.4 -0.2 -0.3 -0.7 -0.7 -0.3 -0.1 -1.1
Medication for pain relief, constipation, heartburn 0.4 0.7 1.4 -0.7 1.0 -1.0 -1.2 -0.6 -0.1 -1.0 -0.8 -0.4
Neck or shoulder pain in last month 0.1 0.2 0.7 0.4 0.0 0.6 -0.1 -0.1 -0.8 -0.0 -0.2 -0.4
Medication: Blood pressure 0.4 0.8 3.5 -0.2 -0.1 0.5 0.7 0.3 1.4 0.1 1.9 0.8
Angina (self-reported) 0.1 0.1 0.3 0.1 -0.5 0.6 0.5 0.4 0.2 0.6 -0.0 0.0
Migraine (self-reported) 0.4 0.6 1.9 0.5 -0.8 1.4 0.6 0.0 -0.7 0.8 -0.5 -0.6
Medication: Ibuprofen 0.2 0.2 0.6 0.2 0.0 -0.6 -0.4 -0.1 -0.7 -0.0 -0.8 -0.3
Medication: Allopurinol 0.4 0.5 1.4 -1.2 0.8 0.0 -0.6 -1.0 -0.9 -0.7 0.0 0.1
Medication: Omeprazole 0.5 0.6 1.8 -1.1 0.7 0.4 -0.3 -1.0 -1.3 -0.6 -0.2 0.6
Medication: Seretide 50 evohaler 0.5 0.5 2.0 -0.8 0.7 -0.1 -0.4 -0.8 -0.6 -0.7 -0.1 -1.4
Mean time to correctly identify matches 0.8 1.4 3.8 -1.1 1.1 0.5 -0.7 -1.5 -1.9 -1.1 -0.7 -1.4
Heart disease (mother) 0.4 0.5 1.6 0.8 -0.6 1.0 0.8 0.2 -0.2 0.5 -0.4 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.6 1.3 -0.8 -1.3 0.2 1.5 1.9 0.8 0.8 0.5
Whole body fat mass 0.4 1.5 5.4 -1.1 1.3 -2.3 -1.6 -0.8 -0.3 -1.1 0.3 -0.6
Leg fat mass (right) 0.1 0.5 0.8 -0.8 0.8 -0.9 -0.8 -0.6 -0.4 -0.6 0.5 -0.6
Arm predicted mass (right) 0.4 2.1 4.2 -1.1 1.4 -1.5 -1.5 -1.5 -1.1 -1.4 -1.2 -2.1
Pulse rate, automated reading 1.1 3.4 5.1 -2.3 1.9 -1.1 -1.7 -2.2 -1.2 -1.9 -2.0 -2.0
Alcohol intake frequency. 0.6 1.4 2.5 -1.3 1.1 -0.9 -1.4 -1.2 -1.3 -1.0 -0.1 -1.6
Comparative height size at age 10 0.2 0.9 1.9 -0.6 0.1 1.3 1.4 -0.1 0.9 -0.0 1.3 1.1
Number of full sisters 0.8 1.0 3.4 -1.8 1.4 0.3 -0.4 -1.3 -0.3 -1.3 0.3 0.3
Suffer from ‘nerves’ 0.4 0.6 1.0 0.9 -0.7 0.8 1.0 0.6 0.4 0.6 0.6 0.9
Overall health rating 0.3 0.7 2.6 0.2 -0.7 1.6 1.2 0.5 0.3 0.8 0.8 0.6
Chest pain or discomfort 1.3 1.9 6.6 1.0 -1.3 2.6 2.0 0.9 0.5 1.3 1.0 0.3
Had major operations 0.3 0.3 1.5 0.1 -0.4 1.2 0.5 -0.0 -0.8 0.3 0.6 -0.3
Age at last live birth 1.4 2.0 4.1 2.0 -2.0 0.4 1.5 1.7 1.0 2.0 0.2 -0.1
Family relationship satisfaction 3.1 3.8 6.3 -2.1 2.5 -1.8 -2.3 -2.3 -1.5 -2.5 -0.8 -1.0
Leg pain on walking 0.3 0.3 0.9 -0.6 0.9 -0.2 -0.3 -0.4 0.5 -0.9 0.7 -0.1
Qualifications: NVQ or HND or HNC or equivalent 2.5 3.0 4.3 -1.5 1.8 -2.0 -2.1 -1.6 -1.1 -1.9 -2.1 -1.3
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.3 0.1 -0.3 0.4 0.5 0.5 0.7 0.4 0.9 1.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.6 0.5 -0.1 0.0 -0.2 -0.2 -0.6 0.1 -0.8 -0.5
Medication: Aspirin 1.6 2.1 6.9 0.6 -0.8 0.7 1.6 1.2 2.1 0.8 2.6 1.3
Supplements: Vitamin C 0.1 0.1 0.1 0.1 -0.3 -0.1 0.3 0.2 0.4 0.4 -0.1 -0.2
Knee pain experienced in last month 0.3 0.4 0.7 -0.8 0.8 -0.7 -0.7 -0.7 -0.3 -0.8 0.1 -0.4
Hypertension (Self-reported) 0.3 0.7 2.2 0.2 -0.5 0.7 0.7 0.7 1.0 0.6 1.5 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.7 -0.9 0.3 1.3 0.3 -0.6 -0.6 -0.3 0.8 0.3
Illnesses of father: Heart disease 1.1 1.5 4.1 2.0 -1.5 0.1 1.0 1.7 1.0 1.4 0.0 0.1
Illnesses of siblings: Diabetes 0.1 0.2 0.6 -0.3 0.1 -0.5 -0.0 0.3 0.8 0.0 0.6 -0.0
Smoking status: Previous 1.1 1.6 2.3 -1.1 1.5 -0.7 -1.2 -1.4 -1.5 -1.4 -1.0 -1.3
Forced expiratory volume in 1-second (FEV1), predicted 2.9 6.0 9.7 -3.1 2.8 -2.4 -2.4 -3.0 -1.5 -2.8 -1.8 -1.7
Whole body fat-free mass 0.8 4.7 7.6 -1.8 2.1 -2.3 -2.4 -2.3 -1.8 -2.1 -1.8 -2.8
Leg fat-free mass (right) 0.7 3.7 6.9 -1.8 1.9 -2.6 -2.4 -1.9 -1.2 -1.9 -1.2 -2.1
Arm fat percentage (left) 0.2 0.7 3.3 -0.7 0.7 -1.8 -1.1 -0.3 0.0 -0.6 0.6 -0.2
Average weekly red wine intake 0.3 0.4 0.8 0.8 -0.3 -0.9 -0.0 0.7 0.6 0.3 -0.8 0.6
Handedness (chirality/laterality): Left-handed 1.0 1.2 6.2 -0.1 0.8 -2.5 -1.5 -0.3 -0.1 -0.8 -0.7 0.1
Mood swings 3.5 6.3 8.2 2.9 -2.5 1.2 2.8 2.9 2.7 2.4 2.5 2.4
Loneliness, isolation 0.6 0.9 1.9 -1.3 1.3 0.5 -0.3 -1.2 -0.4 -1.4 0.2 -0.7
Long-standing illness, disability or infirmity 1.4 2.2 4.7 -1.0 1.4 -0.6 -1.8 -1.4 -2.2 -1.3 -1.9 -1.2
Ever had bowel cancer screening 0.3 0.3 0.8 0.4 -0.3 0.6 0.0 0.1 -0.8 0.3 0.8 -0.9
Diabetes diagnosed by doctor 0.3 0.5 1.5 -0.9 0.7 0.2 -0.0 -0.3 0.7 -0.7 1.2 0.4
Ever had stillbirth, spontaneous miscarriage or termination 2.8 3.0 6.1 -2.5 2.2 -1.2 -1.8 -2.2 -1.3 -2.1 -0.4 -0.8
Friendships satisfaction 1.2 1.4 2.5 -1.0 1.6 -1.3 -1.2 -1.3 -0.6 -1.6 -0.9 -0.9
Qualifications: nursing, teaching 0.8 1.2 4.4 -0.3 0.9 -0.2 -0.8 -0.9 -1.3 -0.9 -2.1 -1.2
Commuting to job workplace: Walk 0.9 1.0 2.6 0.7 -1.1 0.1 0.7 1.2 1.1 1.1 0.0 1.6
Eye problems/disorders: Cataract 3.5 4.0 6.3 2.5 -1.9 1.4 2.0 2.5 2.1 1.8 1.5 2.1
Mouth/teeth dental problems: Mouth ulcers 1.9 3.1 6.2 -2.0 1.7 -2.5 -2.3 -1.8 -1.4 -1.6 -0.7 -0.9
Medication for cholesterol 0.6 0.9 3.6 -0.9 1.0 -1.9 -1.0 -0.6 0.5 -1.0 0.3 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.6 0.3 -0.7 0.2 0.3 0.5 -0.0 0.8 -0.0 -0.5
Back pain experienced in last month 0.5 0.8 1.3 -1.1 1.1 -0.8 -1.2 -0.9 -0.6 -1.1 0.2 -0.5
Mineral and other dietary supplements 2.7 3.6 6.2 -2.2 2.3 -2.1 -2.5 -1.9 -1.1 -2.3 -0.4 -1.1
Breast cancer (self-reported) 0.8 1.0 2.0 0.8 -0.8 1.0 1.2 0.9 0.9 0.8 1.4 0.9
Asthma (self-reported) 0.9 1.9 6.7 -0.5 0.7 -0.2 -0.8 -1.0 -1.4 -0.8 -2.3 -2.6
Osteoporosis (self-reported) 3.6 4.5 10.4 0.7 -1.2 1.2 2.2 1.5 2.9 1.2 3.1 3.2
Osteoarthritis (self-reported) 0.1 0.2 0.5 0.4 -0.3 -0.6 -0.2 0.5 0.3 0.3 0.7 0.4
Medication: Aspirin 1.7 2.2 6.7 0.4 -0.8 1.0 1.7 1.1 2.0 0.8 2.6 1.6
Medication: Gliclazide 0.3 0.3 1.2 -0.5 0.4 -0.4 0.0 0.1 0.9 -0.3 0.1 1.1
Illnesses of father: None of the above (group 1) 0.3 0.4 1.4 0.3 -0.8 0.4 0.6 0.4 0.1 0.8 0.2 1.2
Smoking status: Current 0.0 0.1 0.5 -0.7 0.2 -0.1 -0.1 -0.3 0.3 -0.1 0.0 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.1 0.7 -1.0 0.9 0.6 0.3 -0.5 1.0 -0.7 -0.8
Whole body water mass 0.7 3.8 6.2 -1.6 1.9 -2.1 -2.2 -2.0 -1.6 -1.9 -1.6 -2.5
Leg predicted mass (right) 0.7 3.6 7.0 -1.7 1.9 -2.6 -2.3 -1.8 -1.1 -1.8 -1.1 -2.0
Arm fat mass (left) 0.2 0.7 2.3 -0.8 0.8 -1.5 -1.1 -0.6 -0.4 -0.7 0.2 -0.6
Number of self-reported non-cancer illnesses 1.7 3.0 6.8 1.8 -2.0 2.6 2.0 1.6 0.3 2.1 1.4 0.6
Average weekly champagne plus white wine intake 1.0 1.4 2.5 1.0 -1.3 1.3 1.3 1.1 0.7 1.3 0.9 1.6
Miserableness 1.9 3.2 4.5 2.1 -1.9 1.3 2.1 2.0 1.6 1.8 1.7 1.5
Guilty feelings 0.0 0.1 0.2 -0.0 -0.2 0.4 0.3 0.1 -0.2 0.3 0.2 0.3
Wears glasses or contact lenses 0.1 0.1 0.3 -0.1 0.2 0.1 0.2 -0.3 -0.1 -0.1 -0.3 0.6
Ever taken oral contraceptive pill 1.2 1.4 2.2 -1.5 1.3 -0.7 -1.2 -1.4 -0.6 -1.3 -1.0 -1.2
Hearing aid user 1.5 1.7 2.3 -1.4 1.5 -0.9 -1.3 -1.5 -1.3 -1.4 -0.5 -1.5
Mother’s age at death 0.6 0.8 3.5 -0.2 0.6 -0.6 -0.9 -0.6 -1.0 -0.6 -1.9 -0.4
Financial situation satisfaction 0.2 0.3 1.0 -0.5 0.5 -0.9 -0.2 -0.1 1.0 -0.5 -0.1 0.1
Tinnitus: Yes, now most or all of the time 3.7 4.3 7.4 -2.1 2.2 -0.3 -1.8 -2.6 -2.7 -2.2 -1.5 -2.2
Commuting to job workplace: Public transport 1.3 1.5 3.2 -0.8 1.1 -0.3 -0.9 -1.4 -1.8 -1.0 -1.7 -1.3
Eye problems/disorders: Glaucoma 2.1 2.5 3.9 -1.9 1.9 -1.1 -2.0 -1.7 -1.4 -1.9 -0.3 -1.2
Medication: Blood pressure 0.5 0.9 1.7 1.1 -1.2 0.2 0.8 1.3 0.9 1.3 0.4 0.4
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.1 -0.7 1.2 -1.4 -0.9 -0.4 0.7 -1.2 0.8 1.0
Supplements: Fish oil (including cod liver oil) 4.1 5.3 8.0 2.1 -2.4 2.6 2.8 2.4 1.8 2.3 2.0 2.2
High cholesterol (Self-reported) 2.6 4.7 7.7 1.8 -2.1 2.2 2.4 2.2 1.9 2.1 2.8 1.7
Medication: Bendroflumethiazide 1.3 1.9 3.7 1.0 -1.1 0.3 1.2 1.5 1.7 1.2 1.9 1.8
Medication: Paracetamol 0.1 0.2 0.4 0.1 -0.4 0.3 0.7 0.2 0.5 0.4 0.6 -0.0
Medication: Lisinopril 0.1 0.1 0.5 -0.1 -0.2 0.7 0.3 0.1 0.0 0.3 -0.2 0.1
Medication: Atorvastatin 0.4 0.5 1.2 -1.1 0.6 0.1 -0.4 -0.8 -0.6 -0.6 1.1 0.3
Illnesses of father: High blood pressure 0.2 0.3 0.9 -0.0 0.1 -0.1 0.3 0.3 0.9 0.0 0.8 0.8
Alcohol drinker status: Never 1.3 1.6 4.8 0.6 -0.8 -0.1 0.7 1.3 1.8 0.9 2.2 1.4
Ever smoked 0.3 0.6 1.0 -0.7 0.7 -0.7 -0.7 -0.9 -1.0 -0.6 -1.0 -0.5
Basal metabolic rate 0.7 3.9 5.5 -1.7 2.0 -2.3 -2.3 -2.0 -1.5 -1.9 -1.4 -2.3
Leg fat percentage (left) 0.1 0.5 1.7 0.5 -0.6 0.4 0.6 0.7 0.3 0.7 1.3 0.5
Arm fat-free mass (left) 0.2 1.1 2.4 -0.9 1.0 -0.7 -1.0 -1.3 -1.1 -1.0 -0.7 -1.6
Number of operations (self-reported) 0.6 0.9 4.1 -0.1 0.0 0.6 -0.2 -0.7 -2.0 -0.0 -1.2 -1.4
Average weekly beer plus cider intake 1.2 1.8 3.9 -1.1 1.2 -0.1 -1.1 -1.4 -2.0 -1.2 -1.4 -1.6
Irritability 0.5 0.9 2.0 1.4 -0.6 0.5 1.2 1.0 1.0 0.6 0.4 1.3
Risk taking 2.6 3.8 7.2 -2.2 2.3 -2.6 -2.7 -1.9 -0.8 -2.4 -0.1 -0.7
Ever had prostate specific antigen (PSA) test 1.4 1.7 3.8 1.1 -1.5 2.0 2.0 0.9 0.4 1.4 0.7 0.8
Fractured/broken bones in last 5 years 0.7 0.9 2.3 0.8 -0.5 -0.7 0.3 1.1 0.9 0.6 1.2 1.5
Age started oral contraceptive pill 0.1 0.2 0.7 0.4 -0.4 -0.3 0.1 0.1 0.0 0.3 -0.3 -0.8
Diastolic blood pressure, automated reading 1.1 3.4 4.6 1.6 -1.9 2.1 2.0 1.7 1.0 2.0 1.9 2.1
Ever depressed for a whole week 0.7 0.8 2.0 -0.5 0.7 -1.1 -1.4 -0.8 -1.2 -0.7 -1.0 -0.2
Unable to work because of sickness or disability 1.3 1.7 4.3 1.1 -1.4 2.1 2.0 1.1 1.0 1.3 0.4 0.3
Commuting to job workplace: Cycle 0.5 0.6 1.5 -0.6 0.5 0.6 -0.4 -0.8 -1.2 -0.5 -0.6 -1.2
Myopia 0.1 0.2 0.3 0.6 -0.5 0.1 0.3 0.5 0.5 0.5 0.3 -0.5
Vascular/heart problems diagnosed by doctor 0.8 2.0 4.3 -0.9 1.2 -1.1 -1.4 -1.4 -1.6 -1.3 -2.1 -1.6
Cholesterol lowering medication 1.2 1.7 2.9 1.7 -1.5 1.1 1.3 1.7 0.8 1.5 1.0 0.9
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.4 -1.0 0.7 -0.2 -0.7 -1.2 -1.6 -0.7 -0.8 -0.6
Pain experienced in last month 0.6 0.9 1.8 1.2 -1.3 0.2 0.9 1.2 0.9 1.3 -0.4 0.4
Supplements: Calcium 3.7 4.0 11.6 -1.3 1.8 -3.4 -2.6 -1.6 -1.2 -1.7 -2.1 -1.3
Basal cell carcinoma (self-reported) 0.3 0.4 1.1 0.8 -0.6 -1.1 -0.2 0.6 -0.2 0.6 -0.6 -0.6
Heart attack/myocardial infarction (self-reported) 0.8 1.1 4.0 0.0 -0.4 0.6 0.9 0.5 1.0 0.5 2.0 1.7
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.8 0.1 0.1 -0.9 -0.7 -0.2 -0.4 -0.1 -0.3 -0.7
Heart disease (siblings) 1.0 1.2 2.4 0.2 -0.8 1.4 1.1 0.9 1.2 0.8 1.6 1.2
Alcohol drinker status: Previous 0.6 0.7 1.8 -1.3 1.0 0.7 -0.4 -1.2 -0.8 -1.0 0.2 -0.3
Pack years of smoking 0.4 0.6 2.5 -0.8 0.4 -0.2 0.3 -0.2 1.3 -0.4 1.6 0.6
Impedance of whole body 0.4 2.0 7.7 -1.3 1.4 -2.8 -1.9 -0.7 0.4 -1.4 -0.3 0.6
Leg fat mass (left) 0.1 0.3 0.8 -0.7 0.6 -0.9 -0.7 -0.4 -0.2 -0.5 0.7 -0.2
Arm predicted mass (left) 0.3 1.6 2.9 -1.2 1.3 -0.9 -1.3 -1.5 -1.3 -1.3 -0.6 -1.7