TWAS hub - C15orf42

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0233	0.0155	4.9e-03	0.006	0.002	0.001	NA	0.024	6.9e-02	1.7e-01	2.4e-01	NA	9.8e-04
2	TCGA	Brain Lower Grade Glioma	0.0735	0.0380	4.9e-07	0.069	0.063	0.050	NA	0.064	2.7e-08	1.1e-07	2.1e-06	NA	9.0e-08
3	TCGA	Pancreatic Adenocarcinoma	0.0870	0.0600	4.4e-03	0.085	0.062	0.061	NA	0.080	2.1e-04	1.3e-03	1.5e-03	NA	3.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pulse wave reflection index	7.1	8.8	9.9	-3.1	-3.0	-2.8
Forced expiratory volume in 1-second (FEV1), predicted	6.8	14.1	15.6	3.7	3.6	3.9
Medication: Bendroflumethiazide	6.5	9.9	11.7	2.9	3.0	3.4
Worrier / anxious feelings	5.7	10.8	13.2	-3.6	-2.9	-3.3
Suffer from ‘nerves’	5.3	8.3	10.1	-2.9	-2.5	-3.2
Hypertension (Self-reported)	5.3	14.7	18.2	3.5	3.7	4.3
High blood pressure	5.2	14.4	18.7	3.4	3.6	4.3
Medication for cholesterol	5.2	7.9	10.5	-2.3	-2.8	-3.2
Standing height	4.8	47.4	50.9	7.1	6.6	6.9
Vascular/heart problems diagnosed by doctor	4.8	13.1	17.3	-3.2	-3.4	-4.2
Relative age of first facial hair	4.5	9.3	12.3	-2.6	-2.9	-3.5
Medication: Lisinopril	4.5	5.9	6.7	2.2	2.4	2.6
Medication: Blood pressure	4.4	8.4	10.9	2.2	3.0	3.3
Height	4.2	81.2	86.3	9.0	8.7	9.3
Trunk fat-free mass	4.1	23.7	25.5	4.7	4.8	5.0
Trunk predicted mass	4.1	23.3	24.9	4.7	4.8	5.0
Systolic Blood Pressure	4.0	20.0	21.3	4.2	4.6	4.6
Breast cancer (self-reported)	3.9	4.7	4.9	-2.1	-2.2	-2.2
Glaucoma (self-reported)	3.8	4.5	5.2	2.0	2.1	2.3
Worry (Nagel 2018)	3.7	7.7	10.0	-3.2	-2.5	-2.6
Number of treatments/medications taken	3.6	6.4	8.1	2.8	2.5	2.2
Arm fat-free mass (right)	3.4	17.7	19.0	4.1	4.2	4.4
Basal metabolic rate	3.3	18.2	19.2	4.1	4.3	4.4
Arm predicted mass (left)	3.3	17.0	19.2	3.9	4.1	4.4
Ever used hormone-replacement therapy (HRT)	3.2	4.0	5.4	2.3	1.9	1.7
Medication: Blood pressure	3.2	5.6	6.7	2.3	2.2	2.6
Arm predicted mass (right)	3.2	16.6	17.9	3.9	4.1	4.2
Whole body fat-free mass	3.2	18.2	18.9	4.2	4.2	4.3
Arm fat-free mass (left)	3.2	16.3	17.5	3.9	4.0	4.2
Cardiovascular Disease	3.1	10.2	12.7	2.7	3.3	3.6
Chronotype (morning person)	3.1	7.2	7.5	-2.7	-2.7	-2.6
Supplements: Zinc	3.1	3.4	3.9	1.6	2.0	1.9
Whole body water mass	3.1	17.9	18.5	4.1	4.2	4.3
Systolic blood pressure, automated reading	3.0	8.7	10.1	2.7	2.9	3.2
Weight	2.9	14.3	15.4	3.6	3.8	3.9
Medication: Lansoprazole	2.9	3.3	4.2	2.0	1.7	1.7
Comparative height size at age 10	2.9	15.7	17.8	4.2	3.7	4.0
Guilty feelings	2.9	4.4	4.9	-2.2	-2.1	-1.9
Ulcerative Colitis	2.8	4.1	4.9	-2.2	-2.2	-1.6
Exposure to tobacco smoke at home	2.7	3.0	4.4	-1.2	-2.1	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.7	6.7	-2.0	-2.6	-2.5
Age at First Birth	2.6	3.8	5.0	-2.2	-1.9	-1.7
Medication for hormone replacement therapy	2.6	2.9	3.3	1.7	1.8	1.6
Nervous feelings	2.6	4.8	6.1	-2.5	-1.9	-2.1
Father’s age at death	2.6	3.5	4.2	-1.5	-2.0	-2.0
Pulse wave peak to peak time	2.6	3.1	3.7	1.9	1.7	1.6
Medication: Ramipril	2.5	3.2	3.8	1.6	2.0	1.8
Waist circumference	2.4	8.8	10.0	2.7	3.0	3.2
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	3.6	1.4	1.9	1.9
Leg fat-free mass (right)	2.4	12.8	13.5	3.7	3.6	3.4
Leg predicted mass (right)	2.4	12.6	13.3	3.6	3.6	3.4
Risk taking	2.4	3.5	4.2	2.0	1.7	1.8
Leg fat-free mass (left)	2.3	12.0	12.3	3.5	3.5	3.4
Relative age voice broke	2.3	3.6	4.8	-1.4	-2.0	-2.2
Leg predicted mass (left)	2.3	12.1	12.4	3.5	3.5	3.4
Primary Biliary Cirrhosis	2.2	3.2	3.4	-1.8	-1.7	-1.8
Had menopause	2.2	2.8	2.8	1.7	1.6	1.7
Pulse rate	2.2	3.7	5.1	2.3	1.6	1.8
Fractured/broken bones in last 5 years	2.2	2.9	4.0	-1.6	-1.4	-2.0
Medication: Levothyroxine sodium	2.1	3.6	4.0	-1.8	-1.9	-2.0
Knee pain experienced in last month	2.1	3.3	4.7	1.8	1.4	2.2
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.2	3.6	-1.8	-1.6	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.3	2.8	-1.5	-1.4	-1.7
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	4.1	-1.3	-2.0	-2.0
Schizophrenia (2014)	1.9	4.1	5.4	-2.3	-2.0	-1.7
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	2.8	1.7	1.5	1.5
Qualifications: nursing, teaching	1.9	3.0	4.0	1.9	2.0	1.2
Eye problems/disorders: Cataract	1.9	2.2	3.7	1.9	1.2	1.2
Multivitamins +/- minerals	1.8	2.3	2.8	-1.3	-1.5	-1.7
Stomach or abdominal pain in last month	1.8	2.2	2.9	1.5	1.7	1.2
Medication: Atenolol	1.8	2.2	3.0	1.7	1.4	1.3
Chronic bronchitis/emphysema (father)	1.8	2.1	3.2	1.8	1.5	0.9
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	3.6	-1.9	-1.4	-1.9
Osteoarthritis (self-reported)	1.8	2.3	2.6	1.5	1.6	1.4
Eye problems/disorders: Glaucoma	1.8	2.2	2.8	1.3	1.4	1.7
Neuroticism (Nagel 2018)	1.7	4.1	5.5	-2.4	-1.7	-2.0
Alzheimer’s Disease (including proxy)	1.7	2.5	3.2	1.8	1.4	1.6
Hand grip strength (left)	1.7	4.4	4.5	2.1	2.1	2.1
Comparative body size at age 10	1.7	4.6	5.2	-2.3	-2.3	-1.9
Eye problems/disorders: None of the above	1.7	2.0	2.3	-1.4	-1.3	-1.5
Whole body fat mass	1.7	6.9	8.2	2.4	2.6	2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	2.1	-1.4	-1.3	-1.4
Ever depressed for a whole week	1.7	2.1	3.7	-1.9	-1.2	-1.0
Schizophrenia (2018)	1.6	3.3	3.8	-1.9	-1.9	-1.6
Pack years adult smoking proportion	1.6	2.4	2.9	1.4	1.5	1.7
Current tobacco smoking	1.6	2.6	2.7	1.7	1.6	1.5
Trunk fat mass	1.6	6.9	7.7	2.5	2.6	2.8
Length of working week for main job	1.6	1.8	2.0	-1.4	-1.2	-1.4
Medication: Amlodipine	1.6	2.3	2.9	1.5	1.3	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	2.7	-1.2	-1.4	-1.6
Angina (self-reported)	1.6	2.1	2.5	1.6	1.5	1.2
Body Mass Index (BMI) (2010)	1.5	2.0	2.3	-1.5	-1.3	-1.5
Diabetes (father)	1.5	1.8	2.4	-1.6	-0.9	-1.5
Alcohol drinker status: Never	1.5	1.8	2.3	-1.5	-1.3	-1.2
Lupus	1.4	2.1	2.3	1.5	1.3	1.5
Waist Hip Ratio (WHR)	1.4	6.2	7.8	2.0	2.6	2.8
Sitting height	1.4	10.1	11.5	3.4	2.8	3.4
Birth weight	1.4	3.0	3.9	2.0	1.6	1.6
Medication for pain relief, constipation, heartburn	1.4	2.4	3.0	-1.7	-1.6	-1.3
Crohns Disease (2012)	1.3	2.1	2.5	1.6	1.5	1.2
Neuroticism	1.3	3.0	4.7	-2.2	-1.4	-1.5
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.0	-1.3	-1.4	-1.3
Average weekly fortified wine intake	1.3	1.5	2.6	-1.6	-0.9	-1.0
Pain all over the body in last month	1.3	1.4	2.0	-1.4	-1.1	-1.0
Neuroticism score	1.3	2.7	4.0	-2.0	-1.3	-1.5
Exposure to tobacco smoke outside home	1.3	1.8	2.2	-1.4	-1.5	-1.0
Worry too long after embarrassment	1.3	2.2	2.7	-1.6	-1.4	-1.4
Pulse rate, automated reading	1.3	4.3	4.8	2.2	1.8	2.2
Alzheimer’s Disease (in mother)	1.2	1.4	1.6	1.2	1.1	1.1
Ulcerative Colitis (UC)	1.2	2.3	3.8	-2.0	-1.4	-1.1
Reaction Time	1.2	2.3	3.5	-1.9	-1.5	-1.1
Average weekly spirits intake	1.2	1.5	2.6	-1.6	-1.2	-0.7
Angina	1.2	1.6	2.1	1.4	1.2	1.0
Medication: Co-codamol	1.2	1.3	1.7	1.1	1.3	1.1
Hip circumference	1.2	5.1	6.1	2.1	2.5	2.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.1	1.4	1.2	0.8
Health satisfaction	1.2	1.6	2.2	1.2	1.5	1.1
Handedness (chirality/laterality): Left-handed	1.2	1.4	1.8	-0.8	-1.3	-1.3
Arm fat mass (left)	1.2	5.0	5.6	2.0	2.3	2.4
Irritability	1.2	2.0	2.9	1.2	1.3	1.7
Leg fat mass (left)	1.2	4.7	5.8	1.9	2.2	2.4
Ovarian Cancer	1.1	1.5	1.7	-1.3	-1.0	-1.3
Type 2 Diabetes (T2D) (2012)	1.1	1.2	1.9	1.0	0.9	1.4
Arm fat mass (right)	1.1	4.7	5.5	1.9	2.2	2.3
Age at first live birth	1.1	1.9	2.5	-1.3	-1.6	-1.2
Leg fat mass (right)	1.1	4.3	5.5	1.8	2.1	2.4
Mean Putamen Volume	1.0	1.1	1.8	1.4	1.1	0.6
Sensitivity / hurt feelings	1.0	1.7	1.8	-1.3	-1.3	-1.3
Depression (self-reported)	1.0	1.2	2.4	-0.7	-0.9	-1.6
Pulse wave Arterial Stiffness index	1.0	1.1	1.4	-1.2	-1.0	-1.0
Number of full sisters	1.0	1.2	1.5	0.9	1.2	1.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.6	-0.9	-1.3	-1.1
Mineral and other dietary supplements	1.0	1.3	1.7	1.0	1.2	1.3
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.5	-1.2	-1.1	-0.8
Diastolic blood pressure, automated reading	1.0	3.2	4.3	1.6	1.7	2.1
Crohns Disease (2017)	0.9	1.9	2.0	1.3	1.4	1.4
Neuroticism (2016)	0.9	1.4	2.0	-1.1	-0.9	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.1	1.3	1.2	1.8
Number of incorrect matches in round	0.9	1.5	2.0	-1.1	-1.4	-1.1
Number of live births	0.9	1.3	1.7	1.3	1.3	0.8
Forced vital capacity (FVC), Best measure	0.9	3.1	3.5	1.9	1.7	1.7
Medication: Aspirin	0.9	1.2	1.7	1.3	0.9	1.0
Pain experienced in last month	0.9	1.4	1.7	-1.3	-1.2	-1.0
Bipolar Disorder or Schizophrenia	0.8	2.0	2.3	-1.5	-1.4	-1.4
Townsend deprivation index at recruitment	0.8	1.1	1.3	1.1	1.1	1.0
Qualifications: None of the above	0.8	1.6	2.5	-1.0	-1.6	-1.2
Leg pain on walking	0.8	1.1	1.2	1.0	1.0	1.1
Medication: Aspirin	0.8	1.0	1.4	1.2	1.0	0.9
Number of operations (self-reported)	0.8	1.2	2.2	1.5	1.2	0.2
Pack years of smoking	0.8	1.2	1.7	0.9	1.0	1.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.3	-0.7	-1.1	-0.7
Triglycerides	0.6	1.0	1.4	0.9	1.2	0.7
Blood White Count	0.6	4.5	5.3	-2.3	-2.3	-1.7
Hand grip strength (right)	0.6	1.7	1.8	1.2	1.3	1.4
Forced vital capacity (FVC)	0.6	2.3	2.5	1.6	1.5	1.5
Illnesses of siblings	0.6	0.8	1.2	-0.7	-0.9	-1.1
Alcohol intake versus 10 years previously	0.6	0.9	1.7	-0.6	-1.3	-0.7
Noisy workplace	0.6	0.7	1.2	0.8	0.5	1.1
Had major operations	0.6	0.7	1.1	0.9	1.0	0.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	-0.8	-1.2	-0.4
Commuting to job workplace: Cycle	0.6	0.7	1.0	-0.6	-0.9	-1.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.0	1.0	0.8	0.8
Schizophrenia vs Biploar Disorder	0.5	0.6	0.7	-0.8	-0.7	-0.8
Breast Cancer	0.5	1.3	2.2	0.7	1.1	1.5
Bipolar Disorder (2011)	0.5	0.5	0.8	0.6	0.5	0.9
Trunk fat percentage	0.5	2.2	2.6	1.4	1.4	1.6
Supplements: Glucosamine	0.5	0.7	0.9	-0.5	-1.0	-1.0
Hair/balding pattern: Pattern 2	0.5	0.7	1.1	-0.9	-0.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.0	1.0	1.0	0.8
Medication: Cholesterol lowering	0.5	0.8	1.1	1.0	0.7	1.0
Loud music exposure frequency	0.5	0.6	0.8	-0.7	-0.9	-0.7
Medication: Seretide 50 evohaler	0.5	0.6	1.5	1.2	0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	-1.1	-0.6	-0.2
Supplements: Vitamin C	0.5	0.6	0.6	0.7	0.8	0.8
Friendships satisfaction	0.5	0.6	0.9	0.9	0.7	0.7
Number of self-reported non-cancer illnesses	0.5	0.8	0.9	0.9	0.9	0.8
Financial situation satisfaction	0.5	0.7	1.4	0.0	1.2	0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.1	-1.0	-0.6	-0.6
Depressed Affect (Nagel 2018)	0.4	0.9	1.4	-1.2	-0.5	-1.0
Fasting Glucose	0.4	0.5	0.9	0.5	1.0	0.6
Rheumatoid Arthritis	0.4	0.6	1.0	1.0	0.7	0.4
Lung FEV1/FVC ratio	0.4	1.8	1.9	-1.4	-1.3	-1.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.7	-0.9	-0.4	-0.8
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	0.9	0.7	0.5
Severe depression (siblings)	0.4	0.4	1.1	-0.1	0.4	1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.5	-0.7	-0.7	-0.5
Heart attack	0.4	0.5	0.7	0.8	0.6	0.7
Diabetes (self-reported)	0.4	0.6	1.3	1.2	0.4	0.4
Medication: Simvastatin	0.4	0.6	0.9	0.4	0.8	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	1.5	1.2	1.2	1.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	0.2	0.7	1.0
Blood clot in the leg (DVT)	0.4	0.6	1.2	-1.1	-0.4	-0.5
Body fat percentage	0.4	1.8	2.3	1.1	1.3	1.5
Leg fat percentage (right)	0.4	1.3	2.3	0.8	1.1	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.6	-0.6	-0.7	-0.8
Mean time to correctly identify matches	0.4	0.7	1.2	-1.1	-0.9	-0.4
Family relationship satisfaction	0.4	0.5	0.8	-0.9	-0.6	-0.6
Illnesses of siblings: Diabetes	0.4	0.6	0.8	0.7	0.9	0.6
Smoking status: Current	0.4	0.6	0.6	0.8	0.8	0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	-0.7	-0.9	-0.4
Ever smoked	0.4	0.7	1.1	-0.7	-1.0	-0.7
Leg fat percentage (left)	0.4	1.5	2.3	0.9	1.2	1.5
Prostate Cancer	0.3	0.4	0.9	-0.3	-0.6	-0.9
Heel T-Score	0.3	2.7	3.5	1.9	1.2	1.8
Vitamin and mineral supplements	0.3	0.4	0.6	0.6	0.6	0.8
Maternal smoking around birth	0.3	0.5	1.2	-0.0	-0.5	-1.1
Age when periods started (menarche)	0.3	0.7	1.0	0.6	0.8	1.0
Past tobacco smoking	0.3	0.5	1.0	0.6	1.0	0.4
Had other major operations	0.3	0.4	0.9	0.9	0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.1	0.8	0.6	1.1
Mouth/teeth dental problems	0.3	0.4	0.7	-0.5	-0.6	-0.8
Allergy	0.3	0.7	1.3	1.1	0.8	0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.1	1.0	1.0	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	0.5	0.9	0.3
Birth weight of first child	0.3	0.5	1.0	1.0	0.6	0.2
Headache pain in last month	0.3	0.5	0.5	-0.7	-0.7	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	0.7	0.8	0.4
Heart disease (mother)	0.3	0.4	1.0	1.0	0.3	0.3
Overall health rating	0.3	0.7	1.1	0.8	1.0	0.7
Loneliness, isolation	0.3	0.4	1.0	-0.3	-0.3	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	0.8	0.5	0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	-0.9	-0.6	-0.4
Wears glasses or contact lenses	0.3	0.3	0.5	-0.7	-0.5	-0.5
Illnesses of father: High blood pressure	0.3	0.3	0.6	0.4	0.8	0.5
Age started oral contraceptive pill	0.3	0.4	0.4	-0.6	-0.7	-0.6
Cholesterol lowering medication	0.3	0.5	1.2	0.1	0.5	1.1
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.6	0.7	0.8	0.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	-1.0	-0.5	-0.3
Major Depression (MDD)	0.2	0.2	0.7	-0.8	-0.1	-0.2
Blood Red Count	0.2	1.6	3.6	0.7	0.9	1.9
Hearing difficulty/problems: Yes	0.2	0.3	0.5	-0.7	-0.6	-0.3
Fed-up feelings	0.2	0.4	0.6	-0.7	-0.3	-0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.1	-0.4	-0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	-0.9	-0.8	-0.5
High blood pressure (mother)	0.2	0.3	0.6	-0.8	-0.3	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.5	-0.8	0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	-0.5	0.2	0.6
Arm fat percentage (right)	0.2	0.7	1.0	0.5	0.8	1.0
Time employed in main current job	0.2	0.2	0.5	-0.7	-0.3	-0.2
Hair/balding pattern: Pattern 3	0.2	0.2	0.4	0.6	0.5	0.3
Asthma	0.2	0.3	0.4	0.6	0.6	0.4
Lung cancer (father)	0.2	0.2	0.3	-0.5	-0.6	-0.1
Illnesses of mother	0.2	0.2	0.4	-0.6	-0.4	-0.4
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	-0.3	-0.8	-0.6
Peak expiratory flow (PEF)	0.2	0.4	0.5	0.6	0.7	0.5
Medication: Paracetamol	0.2	0.4	0.7	0.8	0.4	0.5
High blood pressure (siblings)	0.2	0.4	0.4	0.5	0.7	0.6
Number of full brothers	0.2	0.2	0.3	-0.5	-0.5	-0.4
Number of children fathered	0.2	0.2	0.3	-0.5	-0.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.3	0.4	0.7
Migraine (self-reported)	0.2	0.2	0.6	-0.1	-0.8	-0.2
Medication: Ibuprofen	0.2	0.2	0.4	0.5	0.6	0.2
Medication: Omeprazole	0.2	0.3	0.7	-0.8	-0.4	-0.1
Alcohol intake frequency.	0.2	0.5	0.6	-0.6	-0.7	-0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	0.6	0.4	0.5
Average weekly red wine intake	0.2	0.3	0.5	0.4	0.7	0.5
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.3	-0.7	-0.3
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.7	-0.4	-0.2
Ever taken oral contraceptive pill	0.2	0.2	0.2	0.5	0.4	0.4
Average weekly beer plus cider intake	0.2	0.3	0.4	0.6	0.4	0.7
Supplements: Calcium	0.2	0.3	0.7	-0.8	-0.2	-0.1
Depression (Nagel 2018)	0.1	0.1	0.2	-0.4	0.1	-0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.5	-0.1	-0.0
HbA1C	0.1	0.1	0.2	0.1	0.5	-0.5
Blood Platelet Count	0.1	0.9	1.1	1.0	0.8	1.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.6	0.4	0.3
Lung FVC	0.1	0.3	0.4	-0.5	-0.6	-0.5
Hair Pigment	0.1	2.1	2.8	-1.4	-1.7	-1.3
Tanning	0.1	1.0	1.4	-0.8	-1.2	-0.9
Medication: Metformin	0.1	0.1	0.4	-0.0	-0.2	-0.6
Diabetes (mother)	0.1	0.2	0.5	0.1	0.7	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	0.4	-0.1	-0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.5	0.2	0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.4	0.1	-0.5
Body mass index (BMI)	0.1	0.6	0.8	0.4	0.8	0.9
Impedance of leg (left)	0.1	0.6	1.1	0.6	0.6	1.0
Financial difficulties in last 2 years	0.1	0.1	0.1	0.3	0.3	0.3
Impedance of arm (right)	0.1	0.3	0.4	-0.4	-0.6	-0.6
Happiness	0.1	0.1	0.3	-0.6	0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.4	0.2	0.2
Breastfed as a baby	0.1	0.2	0.2	-0.3	-0.4	-0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.2	0.6	0.4
Gout (self-reported)	0.1	0.1	0.2	0.0	0.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.4	-0.3	-0.2
Qualifications: College or University degree	0.1	0.4	0.5	-0.7	-0.6	-0.5
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.4	-0.3	-0.4
Medication: Allopurinol	0.1	0.1	0.2	0.0	0.2	0.4
Chest pain or discomfort	0.1	0.2	0.4	0.7	0.4	0.1
Age at last live birth	0.1	0.1	0.3	-0.2	-0.3	-0.5
Smoking status: Previous	0.1	0.1	0.2	-0.2	-0.4	-0.0
Arm fat percentage (left)	0.1	0.5	0.6	0.5	0.8	0.8
Mood swings	0.1	0.1	0.2	-0.5	-0.2	-0.1
Ever had bowel cancer screening	0.1	0.1	0.2	-0.1	-0.1	0.4
Diabetes diagnosed by doctor	0.1	0.1	0.3	0.6	-0.1	-0.0
Medication: Gliclazide	0.1	0.1	0.2	0.1	-0.4	-0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.4	-0.0	0.6	0.2
Hearing aid user	0.1	0.1	0.1	-0.2	-0.3	0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.1	-0.5	0.2
Medication: Paracetamol	0.1	0.1	0.1	0.3	-0.3	-0.4
Medication: Atorvastatin	0.1	0.2	0.3	-0.2	-0.6	0.3
Unable to work because of sickness or disability	0.1	0.1	0.2	0.2	0.1	-0.4
Myopia	0.1	0.2	0.6	-0.8	-0.1	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.6	-0.1	0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.1	-0.3	-0.5
Heart disease (siblings)	0.1	0.2	0.3	-0.1	0.4	0.5
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.0	0.1	-0.2
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	-0.0	-0.1	-0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.1
HDL Cholesterol	0.0	0.1	0.1	-0.0	-0.1	0.4
LDL Cholesterol	0.0	0.1	0.2	0.1	0.4	0.1
Blood Eosinophil Count	0.0	0.2	0.5	-0.7	-0.3	-0.3
BMI	0.0	0.1	0.2	-0.3	0.2	0.4
Smoking Status	0.0	0.1	0.3	-0.2	-0.1	-0.5
Allergy or Eczema	0.0	0.1	0.1	-0.2	-0.2	0.3
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.1	0.2	-0.3
Respiratory disease	0.0	0.0	0.1	-0.1	0.2	-0.3
Impedance of leg (right)	0.0	0.1	0.4	0.1	0.0	0.6
Taking other prescription medications	0.0	0.0	0.0	0.1	0.1	-0.0
Qualifications: CSEs or equivalent	0.0	0.0	0.0	-0.2	0.2	0.2
Alcohol usually taken with meals	0.0	0.0	0.1	-0.1	-0.0	0.4
Fluid intelligence score	0.0	0.1	0.2	0.2	0.0	0.5
Falls in the last year	0.0	0.1	0.2	0.0	-0.1	-0.4
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	0.3	0.4	-0.0
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	0.1	0.1	0.2
Prospective memory result	0.0	0.0	0.0	0.2	0.0	0.1
Impedance of arm (left)	0.0	0.1	0.2	-0.1	-0.4	-0.5
Tense / ‘highly strung’	0.0	0.1	0.1	-0.2	-0.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	-0.2	-0.3
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.1	-0.2	-0.3
Shortness of breath walking on level ground	0.0	0.0	0.0	-0.1	0.0	-0.1
Neck or shoulder pain in last month	0.0	0.0	0.0	0.1	0.0	-0.1
Illnesses of father: Heart disease	0.0	0.0	0.1	0.2	0.2	0.0
Long-standing illness, disability or infirmity	0.0	0.0	0.0	-0.1	0.0	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.2	-0.1	-0.2
Back pain experienced in last month	0.0	0.0	0.1	0.1	0.3	-0.0
Asthma (self-reported)	0.0	0.1	0.2	0.3	0.4	0.2
Miserableness	0.0	0.0	0.1	-0.2	0.2	0.0
Mother’s age at death	0.0	0.0	0.1	0.4	-0.0	-0.0
Commuting to job workplace: Public transport	0.0	0.0	0.0	0.2	0.0	-0.0
High cholesterol (Self-reported)	0.0	0.1	0.3	0.1	-0.0	0.5
Alcohol drinker status: Previous	0.0	0.0	0.0	0.1	0.1	0.1
Impedance of whole body	0.0	0.1	0.1	-0.1	-0.4	-0.2

Hub : Genes

C15orf42

Models

Trait associations