TWAS hub - BLM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.405	0.0343	0.00000	0.349	0.292	0.355	0.35	0.353	7.4e-120	5.2e-97	2.7e-122	2.8e-120	1.0e-121
2	TCGA	Colon Adenocarcinoma	0.075	0.0340	0.00015	0.025	0.052	0.018	NA	0.035	1.3e-02	5.7e-04	3.1e-02	NA	4.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Irritability	9.2	15.6	15.9	-4.0	-3.9
Fed-up feelings	8.3	15.1	15.1	-3.9	-3.9
Chronic bronchitis/emphysema (father)	5.6	6.6	10.4	-1.7	-3.2
Average weekly red wine intake	5.4	7.9	11.6	2.0	3.4
Pain experienced in last month	5.2	8.6	16.7	0.7	4.1
Leg pain on walking	5.1	6.4	7.3	-2.7	-2.3
Health satisfaction	4.9	6.3	7.7	-2.8	-2.2
Ever highly irritable/argumentative for 2 days	4.8	5.8	7.0	-2.6	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.3	5.0	5.4	-2.2	-2.3
Neck or shoulder pain in last month	3.9	5.5	8.2	-1.7	-2.9
Commuting to job workplace: Walk	3.9	4.3	6.5	-2.5	-1.4
Osteoarthritis (self-reported)	3.8	4.9	6.9	-2.6	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	4.9	7.0	-2.6	-1.7
Falls in the last year	3.6	4.9	6.1	-1.9	-2.5
Number of live births	3.6	5.2	6.4	-2.0	-2.5
Frequency of depressed mood in last 2 weeks	3.4	4.8	6.6	-1.7	-2.6
Tinnitus: Yes, but not now, but have in the past	3.3	3.5	5.0	2.2	1.4
Prospective memory result	3.1	3.8	4.5	-2.1	-1.7
Ever depressed for a whole week	3.1	3.8	5.7	-2.4	-1.4
Neuroticism score	3.0	6.2	7.2	-2.3	-2.7
Mood swings	2.9	5.3	6.2	-2.1	-2.5
Lung cancer (father)	2.8	3.3	3.4	-1.8	-1.8
Bipolar Disorder (2011)	2.7	2.6	5.3	2.3	0.0
Chronic bronchitis/emphysema (mother)	2.7	3.2	4.6	-1.3	-2.1
Miserableness	2.6	4.6	7.6	-1.2	-2.8
Age at First Birth	2.5	3.7	4.5	-2.1	-1.7
Sensitivity / hurt feelings	2.5	4.3	5.4	-1.8	-2.3
Medication: Gliclazide	2.5	2.8	3.0	1.6	1.7
Depression (Nagel 2018)	2.4	3.6	4.7	-2.2	-1.6
Standing height	2.4	24.0	36.7	6.1	3.4
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.1	8.3	2.9	1.4
Neuroticism	2.3	5.5	6.6	-2.1	-2.6
Comparative height size at age 10	2.3	12.5	21.0	4.6	2.0
Multivitamins +/- minerals	2.2	2.8	3.1	-1.8	-1.6
Time employed in main current job	2.2	2.6	2.6	-1.6	-1.6
Medication for pain relief, constipation, heartburn	2.2	3.8	6.7	2.6	0.9
Medication: Blood pressure	2.2	3.8	7.4	-2.7	0.5
Guilty feelings	2.2	3.3	4.5	-2.1	-1.5
Stomach or abdominal pain in last month	2.1	2.7	3.2	-1.5	-1.8
Forced vital capacity (FVC)	2.1	8.0	12.2	3.5	2.0
Exposure to tobacco smoke outside home	2.1	2.8	3.3	-1.8	-1.5
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	3.6	-1.9	-1.2
Mean Putamen Volume	2.0	2.3	4.2	-0.7	-2.0
LDL Cholesterol	2.0	3.2	3.8	1.9	1.6
Noisy workplace	2.0	2.5	4.2	-0.8	-2.1
Medication: Bendroflumethiazide	2.0	3.1	5.8	-2.4	-0.7
Depressed Affect (Nagel 2018)	1.9	3.9	5.2	-1.6	-2.3
Neuroticism (2016)	1.9	2.7	2.8	-1.7	-1.6
Ulcerative Colitis	1.9	2.8	4.7	0.9	2.2
Height	1.9	37.2	56.0	7.5	4.3
Relative age voice broke	1.9	2.9	3.9	-2.0	-1.4
Loud music exposure frequency	1.9	2.0	3.4	-0.8	-1.8
Breast cancer (self-reported)	1.9	2.3	2.5	1.4	1.6
Neuroticism (Nagel 2018)	1.8	4.3	4.7	-2.0	-2.2
Worrier / anxious feelings	1.8	3.4	6.6	-2.6	-0.3
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	3.6	1.6	-1.9
Average weekly beer plus cider intake	1.8	2.6	4.0	-1.1	-2.0
Medication: Metformin	1.7	2.4	4.3	0.8	2.1
Taking other prescription medications	1.7	2.7	5.4	-2.3	0.0
Alcohol intake versus 10 years previously	1.7	2.5	2.9	1.7	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.9	-0.1	2.0
Number of self-reported non-cancer illnesses	1.7	2.9	5.9	-2.4	0.1
Alcohol usually taken with meals	1.6	2.6	3.7	1.2	1.9
Pain all over the body in last month	1.6	1.7	2.6	-1.6	-0.8
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	9.9	3.1	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.1	-0.4	-1.8
Fractured/broken bones in last 5 years	1.6	2.1	3.5	-1.9	0.8
BMI	1.5	8.8	11.0	-2.6	-3.3
Number of treatments/medications taken	1.5	2.7	5.3	-2.3	0.2
Sitting height	1.5	10.7	13.8	3.7	2.8
Body mass index (BMI)	1.5	6.4	7.0	-2.6	-2.4
Arm fat percentage (right)	1.5	6.0	6.4	-2.4	-2.5
Tense / ‘highly strung’	1.5	2.6	3.2	-1.4	-1.8
Comparative body size at age 10	1.5	4.2	4.9	-2.2	-1.8
Medication: Omeprazole	1.5	1.8	2.9	-1.7	-0.8
Ever had bowel cancer screening	1.5	1.8	3.3	-0.6	-1.8
Number of operations (self-reported)	1.5	2.3	3.0	-1.7	-1.3
Hearing difficulty/problems: Yes	1.4	2.2	2.6	1.6	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	2.4	-1.4	-1.5
Medication: Cholesterol lowering	1.4	2.3	4.2	-0.6	2.0
Depression (self-reported)	1.4	1.6	1.8	-1.3	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	3.0	-0.6	-1.7
Leg fat percentage (left)	1.4	5.2	6.8	-2.6	-1.9
Triglycerides	1.3	2.2	3.7	-0.8	-1.9
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.0	-0.5	-1.7
Mouth/teeth dental problems	1.3	2.0	2.9	1.0	1.7
Fluid intelligence score	1.3	2.6	5.2	0.1	2.3
Hair/balding pattern: Pattern 3	1.3	1.9	3.3	-1.8	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	7.4	2.7	0.9
Leg fat percentage (right)	1.3	4.9	7.0	-2.6	-1.7
Pulse wave peak to peak time	1.3	1.5	2.2	1.5	0.9
Diabetes diagnosed by doctor	1.3	2.2	3.6	0.9	1.9
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.5	-1.6	-0.6
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	2.8	-1.7	-0.5
Emphysema/chronic bronchitis	1.2	1.3	2.4	-1.6	0.4
Number of full sisters	1.2	1.4	2.2	-0.8	-1.5
Had major operations	1.2	1.4	1.7	-1.3	-1.0
Mother’s age at death	1.2	1.4	1.7	-1.3	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	1.8	-1.2	-1.3
Illnesses of siblings	1.1	1.5	1.7	1.3	1.1
Father’s age at death	1.1	1.4	2.5	1.6	-0.6
Medication: Lansoprazole	1.1	1.2	2.2	-0.6	-1.5
Hair/balding pattern: Pattern 4	1.1	2.7	4.4	1.0	2.1
Qualifications: College or University degree	1.1	3.6	4.3	1.7	2.1
Arm fat percentage (left)	1.1	4.5	5.3	-1.9	-2.3
Systolic Blood Pressure	1.0	5.2	10.4	0.0	3.2
Systolic blood pressure, automated reading	1.0	2.9	5.8	-0.1	2.4
Medication: Co-codamol	1.0	1.2	1.7	-1.3	-0.9
Forced vital capacity (FVC), Best measure	1.0	3.7	5.5	2.4	1.3
Supplements: Vitamin C	1.0	1.2	2.3	0.5	1.5
Knee pain experienced in last month	1.0	1.6	1.7	-1.3	-1.2
Ever smoked	1.0	1.8	3.7	0.1	-1.9
Unable to work because of sickness or disability	1.0	1.2	2.5	-1.6	0.1
Ulcerative Colitis (UC)	0.9	1.6	1.6	1.3	1.3
Hand grip strength (left)	0.9	2.3	4.5	2.1	-0.1
Vitamin and mineral supplements	0.9	1.2	1.6	1.3	0.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.3	-0.2	-1.5
Headache pain in last month	0.9	1.5	2.3	0.8	-1.5
High blood pressure (siblings)	0.9	1.4	1.9	-1.4	-0.9
Age at first live birth	0.9	1.6	3.2	1.8	0.0
Shortness of breath walking on level ground	0.9	1.1	2.1	0.3	-1.5
Medication: Seretide 50 evohaler	0.9	1.1	1.2	1.1	1.0
Hypertension (Self-reported)	0.9	2.6	3.1	-1.8	1.4
Supplements: Calcium	0.9	0.9	1.0	1.0	-0.9
Smoking Status	0.8	1.8	3.2	-0.6	-1.8
Qualifications: CSEs or equivalent	0.8	1.1	1.6	0.8	1.3
Past tobacco smoking	0.8	1.4	2.4	0.7	1.5
Hair/balding pattern: Pattern 2	0.8	1.1	2.0	1.4	0.4
Arm fat mass (right)	0.8	3.3	3.8	-1.7	-1.9
Heart disease (mother)	0.8	1.0	2.0	-1.4	0.3
Family relationship satisfaction	0.8	1.0	1.4	0.7	1.2
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.5	0.6	1.2
Smoking status: Previous	0.8	1.2	1.7	-0.8	-1.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.2	1.1	0.8
Commuting to job workplace: Public transport	0.8	1.0	1.4	-1.2	-0.7
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.4	0.9	1.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	2.8	1.7	-1.2
Heart disease (siblings)	0.8	1.0	1.3	-1.1	-0.8
Coronary Artery Disease (CAD)	0.7	0.8	0.8	-0.9	0.9
HDL Cholesterol	0.7	1.2	1.5	1.0	1.2
Allergy or Eczema	0.7	1.8	2.8	-1.7	-1.0
Ever had hysterectomy (womb removed)	0.7	0.7	0.9	0.7	1.0
Severe depression (siblings)	0.7	0.8	1.0	-1.0	-0.8
High blood pressure	0.7	1.9	2.0	-1.3	1.4
Supplements: Glucosamine	0.7	0.9	1.0	-0.9	-1.0
Medication: Atenolol	0.7	0.8	1.4	-0.6	1.2
Heart attack	0.7	0.9	1.3	-1.1	-0.7
Happiness	0.7	0.9	1.1	-1.1	-0.8
Mouth/teeth dental problems: Dentures	0.7	1.2	1.5	-1.2	-0.9
Pulse wave Arterial Stiffness index	0.7	0.8	1.2	-1.1	-0.6
Body fat percentage	0.7	2.8	2.9	-1.7	-1.7
Wheeze or whistling in the chest in last year	0.7	1.3	2.6	-0.3	-1.6
Leg fat mass (right)	0.7	2.8	3.1	-1.8	-1.6
Illnesses of father: Heart disease	0.7	1.0	1.5	-0.6	1.2
Financial situation satisfaction	0.7	0.9	1.1	-0.9	-1.0
Eye problems/disorders: Glaucoma	0.7	0.8	1.3	-0.5	1.1
Diastolic blood pressure, automated reading	0.7	2.2	4.1	0.6	2.0
Leg fat mass (left)	0.7	2.9	3.0	-1.7	-1.7
Worry (Nagel 2018)	0.6	1.2	2.3	-1.5	-0.2
Alzheimer’s Disease (in father)	0.6	0.7	0.7	-0.8	-0.8
HbA1C	0.6	0.7	1.1	1.1	0.5
Blood Platelet Count	0.6	6.7	8.2	-2.3	-2.9
Angina	0.6	0.7	0.9	-0.8	0.9
Impedance of leg (right)	0.6	2.7	4.7	0.8	2.2
High blood pressure (mother)	0.6	0.9	1.7	-1.3	0.3
Number of incorrect matches in round	0.6	1.1	2.1	-1.4	-0.2
Medication: Ramipril	0.6	0.7	1.0	-1.0	-0.6
Trunk fat-free mass	0.6	3.4	6.6	2.6	0.6
Impedance of arm (left)	0.6	2.8	3.0	1.7	1.6
Trunk predicted mass	0.6	3.3	6.3	2.5	0.5
Medication: Amlodipine	0.6	0.9	1.6	-0.5	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	0.9	1.0	0.8
Age at last live birth	0.6	0.8	1.6	1.3	-0.3
Qualifications: nursing, teaching	0.6	0.9	1.9	0.1	-1.4
Back pain experienced in last month	0.6	0.9	1.5	1.2	-0.4
Osteoporosis (self-reported)	0.6	0.7	1.5	-0.1	-1.2
Smoking status: Current	0.6	1.0	1.1	-1.0	-1.1
Ever taken oral contraceptive pill	0.6	0.6	1.2	-0.2	-1.1
Medication: Lisinopril	0.6	0.8	1.6	-1.2	0.2
Major Depression (MDD)	0.5	0.6	1.2	-1.1	0.0
Breast Cancer	0.5	1.2	2.3	-1.5	0.2
Rheumatoid Arthritis	0.5	0.7	1.4	1.2	0.2
Blood Eosinophil Count	0.5	3.9	7.9	-2.8	-0.0
Cardiovascular Disease	0.5	1.5	2.7	-0.5	1.7
Lung FEV1/FVC ratio	0.5	2.7	4.0	-1.2	-2.0
Chronotype (morning person)	0.5	1.2	2.2	-0.5	-1.5
Trunk fat percentage	0.5	1.9	2.2	-1.3	-1.5
Hand grip strength (right)	0.5	1.3	2.6	1.6	-0.0
Maternal smoking around birth	0.5	0.8	1.5	-0.2	-1.2
Diabetes (self-reported)	0.5	0.8	1.6	0.1	1.3
Medication: Simvastatin	0.5	0.7	1.3	0.1	1.2
Blood clot in the leg (DVT)	0.5	0.6	1.0	-1.0	0.5
Number of full brothers	0.5	0.7	1.1	1.0	0.5
Worry too long after embarrassment	0.5	0.8	1.0	1.0	-0.8
Overall health rating	0.5	1.1	2.2	-1.5	-0.0
Chest pain or discomfort	0.5	0.8	1.0	-0.7	-1.0
Medication: Aspirin	0.5	0.7	1.2	-1.1	0.4
Whole body fat-free mass	0.5	2.6	5.1	2.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.8	-0.9	-0.7
Medication: Aspirin	0.5	0.6	1.1	-0.4	1.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	1.1	0.2
Whole body water mass	0.5	2.7	5.2	2.3	0.4
Arm fat mass (left)	0.5	1.9	2.5	-1.2	-1.6
Hearing aid user	0.5	0.5	0.9	1.0	-0.4
Medication: Atorvastatin	0.5	0.6	1.3	-1.1	-0.0
Age started oral contraceptive pill	0.5	0.6	1.1	-1.1	-0.4
Commuting to job workplace: Cycle	0.5	0.7	0.8	0.9	0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	-1.0	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.7	-0.7	0.8
Impedance of whole body	0.5	2.7	3.9	1.2	2.0
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.9	-0.4	1.4
Prostate Cancer	0.4	0.6	0.8	0.6	0.9
Respiratory disease	0.4	0.9	1.1	-1.0	-0.9
Average weekly spirits intake	0.4	0.5	0.6	-0.7	-0.8
Supplements: Zinc	0.4	0.5	0.7	-0.5	-0.8
Current tobacco smoking	0.4	0.7	0.9	-0.7	-0.9
Age when periods started (menarche)	0.4	1.0	1.1	0.9	1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	0.2	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.6	-0.2	-1.3
Impedance of leg (left)	0.4	1.8	3.3	0.6	1.8
Waist circumference	0.4	1.4	2.3	-0.8	-1.5
Financial difficulties in last 2 years	0.4	0.6	1.1	-0.1	-1.1
Pulse rate	0.4	0.7	1.3	-1.1	-0.4
Peak expiratory flow (PEF)	0.4	1.0	1.8	1.4	-0.5
Arm fat-free mass (right)	0.4	2.2	4.1	2.0	0.5
Angina (self-reported)	0.4	0.6	0.8	-0.6	0.9
Mean time to correctly identify matches	0.4	0.8	1.5	-0.2	-1.2
Arm predicted mass (right)	0.4	2.3	4.3	2.1	0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.7	0.5	0.8
Illnesses of siblings: Diabetes	0.4	0.5	1.0	-0.0	-1.0
Wears glasses or contact lenses	0.4	0.5	0.5	-0.7	-0.7
Illnesses of father: High blood pressure	0.4	0.5	0.9	-0.4	1.0
Alzheimer’s Disease (in mother)	0.3	0.4	0.6	0.8	-0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.1	-0.9
Irritable Bowel Disease (IBD)	0.3	0.8	1.0	1.0	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	0.6	-0.4	-0.7
Lupus	0.3	0.4	0.5	0.6	-0.7
Schizophrenia (2014)	0.3	0.6	1.1	1.1	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	0.3	0.8
Blood Red Count	0.3	2.5	3.5	1.2	1.9
Blood White Count	0.3	2.2	2.4	-1.4	1.6
Waist Hip Ratio (WHR)	0.3	1.4	2.6	0.4	1.6
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.7	0.5	0.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.4	0.3	0.7
Medication for hormone replacement therapy	0.3	0.3	0.7	0.2	-0.8
Leg fat-free mass (left)	0.3	1.5	3.0	1.7	-0.0
Average weekly fortified wine intake	0.3	0.4	0.6	-0.7	0.5
Leg predicted mass (left)	0.3	1.7	3.3	1.8	0.1
Nervous feelings	0.3	0.5	0.8	-0.6	0.9
Had menopause	0.3	0.4	0.7	-0.9	0.1
Allergy	0.3	0.6	1.1	1.1	0.3
Impedance of arm (right)	0.3	1.5	1.8	1.1	1.3
Illnesses of mother	0.3	0.4	0.7	0.8	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.7	0.1	0.8
Medication: Allopurinol	0.3	0.4	0.5	-0.7	-0.7
Whole body fat mass	0.3	1.4	2.0	-0.9	-1.4
Leg fat-free mass (right)	0.3	1.7	3.3	1.8	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.6	0.7	0.8
Leg predicted mass (right)	0.3	1.7	3.4	1.8	-0.0
Medication: Blood pressure	0.3	0.6	1.1	-1.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.6	-0.2	-0.8
Basal metabolic rate	0.3	1.8	3.6	1.9	0.0
Arm fat-free mass (left)	0.3	1.4	2.7	1.6	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	-0.7	-0.4
Cholesterol lowering medication	0.3	0.4	0.7	0.4	-0.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	-0.9	0.0
Arm predicted mass (left)	0.3	1.4	2.6	1.6	0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	1.0	0.3
Schizophrenia (2018)	0.2	0.5	1.0	1.0	0.1
Reaction Time	0.2	0.4	0.8	0.9	0.1
Crohns Disease (2012)	0.2	0.3	0.7	0.2	0.8
Primary Biliary Cirrhosis	0.2	0.3	0.5	0.7	0.2
Heel T-Score	0.2	1.9	3.8	-0.3	-1.9
Hypothyroidism (self reported)	0.2	0.6	0.6	-0.8	-0.7
Hair Pigment	0.2	4.9	9.6	0.5	-3.1
Diabetes (father)	0.2	0.2	0.4	-0.6	0.3
Pack years adult smoking proportion	0.2	0.2	0.5	0.1	-0.7
Townsend deprivation index at recruitment	0.2	0.3	0.5	-0.1	-0.7
Trunk fat mass	0.2	0.9	1.7	-0.5	-1.3
Hip circumference	0.2	0.8	1.4	-0.5	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.0	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.3	-0.3	-0.5
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.6	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.7	-0.1	-0.9
Birth weight of first child	0.2	0.4	0.7	0.9	-0.3
Medication: Paracetamol	0.2	0.3	0.4	-0.7	-0.3
Gout (self-reported)	0.2	0.2	0.2	-0.5	-0.5
Number of children fathered	0.2	0.2	0.2	-0.4	-0.5
Migraine (self-reported)	0.2	0.2	0.4	0.7	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	0.7	-0.1
Alcohol intake frequency.	0.2	0.4	0.4	-0.6	-0.6
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.2	0.8
Friendships satisfaction	0.2	0.3	0.4	-0.6	0.4
Alcohol drinker status: Never	0.2	0.3	0.4	0.3	0.7
Risk taking	0.2	0.2	0.4	-0.3	-0.6
Alcohol drinker status: Previous	0.2	0.2	0.4	0.3	-0.6
Pack years of smoking	0.2	0.3	0.6	0.1	-0.8
Bipolar Disorder (2018)	0.1	0.1	0.1	0.3	0.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	-0.3	-0.2
Crohns Disease (2017)	0.1	0.2	0.2	0.5	0.4
Ovarian Cancer	0.1	0.2	0.2	-0.4	-0.4
Lung FVC	0.1	0.5	0.8	-0.9	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.2	0.3
Diabetes (mother)	0.1	0.2	0.3	-0.2	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.8	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.0	0.5
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.5	0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.1	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.1	-0.7
Weight	0.1	0.5	1.0	0.1	-1.0
Asthma	0.1	0.3	0.4	-0.3	-0.7
Pulse wave reflection index	0.1	0.1	0.3	0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	0.3	0.3
Glaucoma (self-reported)	0.1	0.2	0.2	-0.5	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	0.3	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.4	-0.3
Pulse rate, automated reading	0.1	0.2	0.4	-0.6	-0.0
Suffer from ‘nerves’	0.1	0.2	0.4	-0.2	-0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.1	-0.3	0.4
Loneliness, isolation	0.1	0.2	0.2	-0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.1	0.4	0.2
Medication for cholesterol	0.1	0.2	0.3	0.2	0.6
Asthma (self-reported)	0.1	0.1	0.2	-0.1	-0.5
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.2	0.4
Medication: Paracetamol	0.1	0.1	0.2	-0.4	0.3
Myopia	0.1	0.2	0.2	-0.5	-0.3
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.1	0.1	0.3
Fasting Glucose	0.0	0.1	0.1	0.3	0.2
Tanning	0.0	0.3	0.4	0.5	0.6
Relative age of first facial hair	0.0	0.0	0.1	0.1	0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.1	0.3
Had other major operations	0.0	0.0	0.0	-0.1	0.1
Qualifications: None of the above	0.0	0.1	0.2	-0.5	0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	-0.3	0.0
Length of working week for main job	0.0	0.0	0.0	-0.0	0.0
Breastfed as a baby	0.0	0.0	0.1	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.3	-0.0
Birth weight	0.0	0.1	0.2	0.4	0.2
Medication: Ibuprofen	0.0	0.1	0.1	0.2	-0.2
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.0	-0.1
Mineral and other dietary supplements	0.0	0.0	0.1	0.2	-0.0
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.1	0.1

Hub : Genes

BLM

Models

Trait associations