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chr19:16,751,207-20,489,861

Best TWAS P=9.09e-30 · Best GWAS P=1.02e-26 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HAPLN4	0.07	0.10	lasso	6	0.10	5.3e-12	7.87	6.9	7.1e-12	-0.08	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MAU2	0.09	0.08	blup	369	0.10	1.0e-12	-1.71	7.0	3.3e-12	-0.77	0.73	0.27	TRUE
3	GTEx	Adipose Subcutaneous	CTD-2521M24.9	0.13	0.04	lasso	3	0.03	7.7e-04	-5.25	5.5	2.8e-08	0.01	0.63	0.01	FALSE
4	GTEx	Artery Aorta	CTD-2521M24.9	0.20	0.18	lasso	2	0.17	8.3e-10	-5.25	5.3	1.1e-07	0.00	0.99	0.00	FALSE
5	GTEx	Artery Tibial	SSBP4	0.09	0.04	lasso	5	0.00	3.0e-01	-6.33	6.3	2.1e-10	-0.08	0.26	0.56	FALSE
6	GTEx	Brain Cerebellar Hemisphere	ATP13A1	0.19	0.15	lasso	2	0.07	7.3e-03	6.75	6.6	4.8e-11	-0.14	0.11	0.09	TRUE
7	GTEx	Brain Cerebellum	ATP13A1	0.17	0.03	enet	30	0.03	5.2e-02	1.69	6.3	3.3e-10	0.00	0.10	0.05	FALSE
8	GTEx	Brain Frontal Cortex BA9	GTPBP3	0.44	0.05	lasso	9	0.09	2.3e-03	5.08	6.4	2.0e-10	-0.06	0.05	0.10	FALSE
9	GTEx	Brain Hippocampus	DDX49	0.23	-0.01	lasso	4	-0.01	6.6e-01	-10.59	10.9	1.3e-27	-0.93	0.01	0.74	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	ELL	0.17	0.00	lasso	5	0.01	2.1e-01	-6.49	6.0	1.7e-09	-0.07	0.11	0.20	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	CTD-2521M24.6	0.41	0.08	lasso	8	0.05	1.0e-02	-5.43	6.1	1.2e-09	0.03	0.27	0.08	TRUE
12	GTEx	Cells EBV-transformed lymphocytes	CTD-2521M24.9	0.49	0.24	lasso	6	0.25	1.2e-08	-4.86	5.8	8.3e-09	0.04	0.98	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	ATP13A1	0.14	0.06	lasso	5	0.05	2.2e-04	-6.80	-6.5	9.8e-11	0.64	0.18	0.58	FALSE
14	GTEx	Cells Transformed fibroblasts	SSBP4	0.09	0.07	lasso	2	0.06	5.5e-05	-6.49	6.5	7.6e-11	-0.08	0.29	0.67	FALSE
15	GTEx	Cells Transformed fibroblasts	MEF2B	0.08	0.08	enet	15	0.09	1.7e-07	-4.82	5.3	1.1e-07	-0.52	0.57	0.34	FALSE
16	GTEx	Colon Sigmoid	RFXANK	0.19	-0.01	enet	38	0.02	9.2e-02	-6.58	5.5	4.9e-08	-0.43	0.04	0.10	FALSE
17	GTEx	Colon Transverse	YJEFN3	0.09	0.09	lasso	3	0.07	4.3e-04	8.21	-8.3	8.8e-17	0.19	0.41	0.03	TRUE
18	GTEx	Esophagus Mucosa	LPAR2	0.08	0.03	lasso	2	0.01	1.1e-01	6.80	-6.7	2.0e-11	0.12	0.30	0.10	TRUE
19	GTEx	Esophagus Mucosa	SSBP4	0.14	0.10	lasso	2	0.14	1.3e-09	-6.49	5.8	4.9e-09	-0.09	0.33	0.67	FALSE
20	GTEx	Esophagus Mucosa	GATAD2A	0.11	0.02	lasso	3	0.02	2.3e-02	-10.59	-10.2	1.7e-24	0.93	0.01	0.92	FALSE
21	GTEx	Esophagus Muscularis	MEF2BNB	0.12	0.00	lasso	4	0.00	7.5e-01	-6.35	6.1	9.3e-10	-0.31	0.05	0.08	FALSE
22	GTEx	Lung	LPAR2	0.07	0.09	lasso	3	0.05	9.9e-05	6.10	-5.5	4.9e-08	0.01	0.89	0.00	FALSE
23	GTEx	Muscle Skeletal	SUGP1	0.11	0.06	lasso	7	0.07	9.5e-08	7.87	-5.6	2.7e-08	-0.06	1.00	0.00	FALSE
24	GTEx	Muscle Skeletal	MAU2	0.09	0.04	lasso	4	0.05	5.1e-06	-10.07	6.9	6.6e-12	-0.86	0.15	0.85	FALSE
25	GTEx	Muscle Skeletal	SSBP4	0.09	0.07	lasso	3	0.07	1.3e-07	-6.33	6.6	3.8e-11	-0.06	0.44	0.56	FALSE
26	GTEx	Nerve Tibial	LPAR2	0.14	0.05	lasso	5	0.06	2.3e-05	6.10	-5.2	2.1e-07	-0.02	0.72	0.02	FALSE
27	GTEx	Skin Sun Exposed Lower leg	SSBP4	0.12	0.12	lasso	3	0.11	2.9e-09	-6.49	6.5	1.2e-10	-0.08	0.42	0.58	FALSE
28	GTEx	Spleen	LPAR2	0.27	0.06	lasso	6	0.04	2.7e-02	1.87	-5.5	3.7e-08	0.08	0.11	0.19	FALSE
29	GTEx	Thyroid	SSBP4	0.09	0.11	lasso	6	0.10	8.2e-08	-6.40	6.2	6.2e-10	-0.08	0.49	0.50	FALSE
30	GTEx	Thyroid	YJEFN3	0.05	0.02	lasso	3	0.02	1.2e-02	8.24	-6.4	1.7e-10	0.06	0.24	0.03	FALSE
31	GTEx	Whole Blood	LPAR2	0.10	0.07	lasso	5	0.07	8.0e-07	6.10	-6.9	5.4e-12	0.18	0.97	0.00	FALSE
32	GTEx	Whole Blood	ELL	0.10	0.03	enet	17	0.04	1.2e-04	-6.40	-5.8	5.2e-09	0.08	0.33	0.60	FALSE
33	GTEx	Whole Blood	LRRC25	0.12	0.01	enet	7	0.02	1.0e-02	-6.49	5.4	6.4e-08	-0.09	0.33	0.45	FALSE
34	METSIM	Adipose	ELL	0.08	0.05	lasso	7	0.06	7.1e-09	-6.74	-7.0	3.1e-12	0.06	0.32	0.68	TRUE
35	NTR	Blood	LPAR2	0.04	0.03	lasso	3	0.03	3.6e-11	6.10	-5.9	4.7e-09	-0.01	1.00	0.00	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	ELL	0.27	0.39	lasso	7	0.39	4.0e-53	-6.70	6.7	2.8e-11	-0.07	0.27	0.73	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	SUGP1	0.03	0.00	blup	364	0.01	4.3e-02	-10.59	-6.4	1.6e-10	0.74	0.02	0.88	TRUE
38	ROSMAP	Brain Pre-frontal Cortex	MAU2	0.17	0.05	bslmm	362	0.06	8.0e-08	-6.66	7.2	8.5e-13	-0.56	0.54	0.36	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	TSSK6	0.04	0.00	blup	346	0.01	1.1e-02	7.89	5.3	9.0e-08	0.01	0.38	0.02	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	HAPLN4	0.05	0.03	enet	15	0.03	1.7e-04	2.17	5.3	1.0e-07	0.11	0.98	0.00	FALSE
41	YFS	Blood	ELL	0.23	0.41	enet	24	0.43	2.6e-158	-6.47	-5.8	5.0e-09	0.07	0.51	0.49	FALSE
42	YFS	Blood	LPAR2	0.14	0.15	lasso	5	0.16	3.6e-48	6.20	-5.5	3.8e-08	-0.03	1.00	0.00	FALSE
43	YFS	Blood	ZNF101	0.02	0.00	enet	16	0.01	2.7e-03	-6.35	-7.5	4.6e-14	0.22	0.15	0.06	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	YJEFN3	0.04	0.05	lasso	7	0.04	1.6e-04	8.43	-7.2	5.4e-13	0.05	0.32	0.02	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	CILP2	0.02	0.02	blup	30	0.02	1.6e-04	8.39	8.0	9.6e-16	-0.16	0.20	0.02	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAPLN4	0.04	0.07	lasso	4	0.06	1.3e-12	7.97	6.1	1.0e-09	-0.01	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	YJEFN3	0.03	0.02	enet	18	0.02	2.1e-04	8.35	-6.6	5.4e-11	0.28	0.31	0.02	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF14	0.03	0.02	lasso	2	0.02	2.1e-05	-4.87	-5.9	4.5e-09	0.04	0.33	0.43	TRUE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC25	0.06	0.05	blup	44	0.04	1.5e-03	-6.33	5.4	7.3e-08	-0.10	0.01	0.92	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	TSSK6	0.07	0.02	blup	32	0.04	2.9e-03	8.21	11.3	9.1e-30	-0.55	0.04	0.20	TRUE
51	The Cancer Genome Atlas	Glioblastoma Multiforme	ELL	0.13	0.10	blup	46	0.08	1.9e-03	-6.70	6.0	1.6e-09	-0.08	0.02	0.88	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SSBP4	0.04	0.03	blup	37	0.04	1.6e-05	-6.70	5.5	3.0e-08	-0.05	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SF4	0.03	0.01	enet	7	0.02	1.1e-03	-1.48	-5.6	2.6e-08	0.70	0.05	0.83	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SSBP4	0.02	0.02	blup	37	0.03	3.7e-04	-6.47	5.5	3.1e-08	-0.09	0.02	0.92	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	-9.99	-10.5	1.4e-25	0.89	0.00	0.98	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SSBP4	0.06	0.07	enet	6	0.07	5.6e-05	-6.47	5.9	3.5e-09	-0.08	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC25	0.07	0.08	blup	46	0.09	2.2e-10	-3.27	5.8	5.2e-09	-0.06	0.25	0.75	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	YJEFN3	0.03	0.03	blup	32	0.02	3.0e-03	8.21	-10.6	3.6e-26	0.44	0.09	0.17	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMIP	0.07	0.00	blup	43	0.02	2.3e-02	1.94	-5.5	2.8e-08	0.57	0.02	0.20	FALSE
60	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LRRC25	0.07	0.03	blup	46	0.02	8.5e-03	-3.09	5.2	1.9e-07	-0.05	0.02	0.75	FALSE
61	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SSBP4	0.06	0.02	blup	37	0.05	4.3e-04	-6.66	5.9	3.0e-09	-0.06	0.01	0.92	FALSE
62	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TSSK6	0.35	0.01	blup	33	0.09	2.8e-04	0.38	7.6	2.1e-14	-0.56	0.00	0.16	TRUE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	ELL	0.03	0.03	blup	47	0.01	1.2e-02	-6.70	6.1	1.3e-09	-0.08	0.01	0.94	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	GATAD2A	0.04	0.03	lasso	2	0.03	2.9e-04	-1.92	-5.5	3.3e-08	0.82	0.03	0.92	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	GTPBP3	0.24	0.09	lasso	3	0.12	9.4e-13	5.08	6.5	1.1e-10	-0.08	0.80	0.20	TRUE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	SSBP4	0.04	0.08	enet	13	0.08	8.4e-09	-6.76	6.4	1.8e-10	-0.07	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	YJEFN3	0.04	0.05	lasso	2	0.05	4.3e-06	8.41	-8.4	3.9e-17	0.20	0.79	0.01	FALSE
68	The Cancer Genome Atlas	Stomach Adenocarcinoma	HAPLN4	0.08	0.03	blup	37	0.04	7.2e-04	7.91	6.8	7.9e-12	-0.22	0.40	0.02	TRUE
69	The Cancer Genome Atlas	Thyroid Carcinoma	ELL	0.06	0.06	blup	46	0.09	1.2e-08	-6.79	5.5	3.0e-08	-0.09	0.02	0.98	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	TM6SF2	0.05	0.04	blup	34	0.05	2.8e-05	-9.99	-9.6	6.8e-22	0.91	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	YJEFN3	0.08	0.06	blup	33	0.08	7.1e-08	8.41	-10.6	3.0e-26	0.41	0.98	0.00	FALSE