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chr2:67,709,195-73,048,938

Best TWAS P=1.31e-43 · Best GWAS P=2.53e-46 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GMCL1	0.06	0.09	lasso	2	0.09	1.5e-10	-5.1	5.1	3.0e-07	0.05	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ZNF638	0.06	0.01	bslmm	559	0.02	1.8e-03	14.2	8.8	1.5e-18	0.69	0.01	0.96	FALSE
3	GTEx	Adipose Subcutaneous	ZNF638	0.09	0.02	lasso	3	0.01	2.9e-02	5.1	5.3	1.1e-07	0.34	0.16	0.57	FALSE
4	GTEx	Adipose Subcutaneous	GMCL1	0.03	0.04	enet	5	0.02	1.0e-02	-5.7	-6.3	3.2e-10	-0.06	0.52	0.12	FALSE
5	GTEx	Adipose Subcutaneous	PAIP2B	0.14	0.06	enet	23	0.05	8.7e-05	6.5	6.4	1.3e-10	0.37	0.94	0.02	FALSE
6	GTEx	Artery Aorta	ZNF638	0.25	0.07	enet	20	0.10	5.2e-06	14.2	13.8	1.3e-43	0.98	0.01	0.99	TRUE
7	GTEx	Artery Aorta	PCYOX1	0.12	0.04	lasso	3	0.02	1.6e-02	-5.8	-5.8	5.1e-09	0.01	0.23	0.38	FALSE
8	GTEx	Artery Aorta	PAIP2B	0.09	0.02	lasso	3	0.02	3.0e-02	6.8	7.1	9.1e-13	0.59	0.28	0.04	FALSE
9	GTEx	Artery Tibial	ZNF638	0.10	0.06	enet	13	0.07	2.4e-06	14.2	12.7	3.5e-37	0.88	0.01	0.99	FALSE
10	GTEx	Artery Tibial	PCYOX1	0.22	0.18	lasso	4	0.17	1.3e-13	-5.8	-5.8	5.4e-09	0.02	1.00	0.00	FALSE
11	GTEx	Artery Tibial	PAIP2B	0.10	0.05	lasso	5	0.05	5.5e-05	6.2	6.2	6.9e-10	0.37	0.87	0.00	FALSE
12	GTEx	Artery Tibial	PPP3R1	0.25	0.22	lasso	4	0.26	5.4e-20	-7.8	-7.8	6.2e-15	-0.04	0.00	1.00	FALSE
13	GTEx	Artery Tibial	RP11-474G23.2	0.17	0.14	lasso	3	0.12	2.3e-09	-7.8	-7.9	2.4e-15	-0.05	0.00	1.00	TRUE
14	GTEx	Brain Cerebellum	GMCL1	0.13	0.11	lasso	3	0.10	5.1e-04	-5.1	5.4	6.7e-08	0.07	0.16	0.22	TRUE
15	GTEx	Cells EBV-transformed lymphocytes	FAM136A	0.31	0.12	lasso	7	0.16	5.6e-06	6.0	7.4	1.8e-13	0.02	0.61	0.24	TRUE
16	GTEx	Cells Transformed fibroblasts	FAM136A	0.22	0.17	lasso	5	0.14	6.2e-11	-5.6	5.8	5.9e-09	0.00	0.54	0.46	FALSE
17	GTEx	Cells Transformed fibroblasts	NFU1	0.10	0.07	lasso	2	0.03	2.0e-03	5.9	-5.9	3.5e-09	0.05	0.48	0.04	FALSE
18	GTEx	Colon Transverse	PCYOX1	0.13	0.01	lasso	3	0.00	2.7e-01	-7.1	-7.2	4.9e-13	0.00	0.13	0.43	FALSE
19	GTEx	Esophagus Muscularis	PCYOX1	0.18	0.16	enet	14	0.15	1.9e-09	-4.3	-5.2	2.2e-07	-0.02	0.88	0.12	FALSE
20	GTEx	Esophagus Muscularis	PAIP2B	0.16	0.07	lasso	6	0.03	3.5e-03	6.4	6.8	1.5e-11	0.35	0.56	0.02	FALSE
21	GTEx	Heart Left Ventricle	FAM136A	0.17	0.09	enet	22	0.09	2.0e-05	-5.5	5.9	2.8e-09	0.00	0.76	0.09	FALSE
22	GTEx	Lung	PAIP2B	0.10	0.07	lasso	8	0.06	1.7e-05	6.0	6.3	2.9e-10	0.35	0.95	0.00	FALSE
23	GTEx	Muscle Skeletal	MCEE	0.10	0.06	enet	8	0.06	1.7e-06	-5.1	-5.2	2.0e-07	-0.36	0.99	0.00	FALSE
24	GTEx	Nerve Tibial	PAIP2B	0.11	0.08	lasso	7	0.07	5.5e-06	6.1	6.4	1.6e-10	0.36	0.94	0.02	FALSE
25	GTEx	Nerve Tibial	GFPT1	0.13	0.01	lasso	4	0.02	1.8e-02	-3.0	5.2	1.9e-07	-0.10	0.23	0.15	FALSE
26	GTEx	Pancreas	PAIP2B	0.18	0.03	lasso	2	0.01	1.1e-01	6.0	6.3	3.9e-10	0.38	0.20	0.04	FALSE
27	GTEx	Skin Sun Exposed Lower leg	PAIP2B	0.14	0.07	enet	39	0.07	3.0e-06	10.3	8.7	2.7e-18	0.66	0.39	0.56	TRUE
28	GTEx	Small Intestine Terminal Ileum	GFPT1	0.24	0.01	enet	19	0.03	8.5e-02	-3.6	6.2	6.6e-10	-0.07	0.08	0.07	TRUE
29	GTEx	Stomach	PAIP2B	0.14	0.13	lasso	1	0.09	2.8e-05	5.8	5.8	7.1e-09	0.39	0.63	0.02	TRUE
30	GTEx	Testis	MCEE	0.17	0.10	enet	14	0.16	2.0e-07	4.5	5.5	3.8e-08	0.29	0.76	0.03	FALSE
31	GTEx	Thyroid	ZNF638	0.11	0.04	enet	13	0.06	1.3e-05	5.1	7.2	5.4e-13	0.66	0.08	0.91	FALSE
32	GTEx	Thyroid	PAIP2B	0.11	0.06	lasso	4	0.04	5.4e-04	6.0	6.5	5.8e-11	0.37	0.43	0.26	FALSE
33	GTEx	Thyroid	PCBP1-AS1	0.11	0.07	lasso	3	0.07	6.6e-06	-6.4	6.6	3.0e-11	0.00	0.81	0.05	FALSE
34	METSIM	Adipose	ASPRV1	0.05	0.06	lasso	3	0.06	2.6e-09	-6.2	6.2	6.0e-10	0.01	0.98	0.02	FALSE
35	METSIM	Adipose	GFPT1	0.07	0.06	blup	460	0.08	1.0e-11	-3.1	5.5	3.6e-08	-0.09	1.00	0.00	TRUE
36	METSIM	Adipose	PAIP2B	0.05	0.03	lasso	9	0.03	5.0e-05	10.3	9.9	5.5e-23	0.75	0.59	0.34	FALSE
37	NTR	Blood	PAIP2B	0.03	0.02	lasso	5	0.01	1.2e-04	-2.9	-5.4	7.2e-08	-0.38	0.90	0.02	TRUE
38	ROSMAP	Brain Pre-frontal Cortex	CYP26B1	0.04	0.02	blup	334	0.02	9.3e-04	3.5	5.8	5.3e-09	-0.01	0.66	0.12	TRUE
39	ROSMAP	Brain Pre-frontal Cortex	GMCL1	0.16	0.17	lasso	9	0.18	1.5e-22	-5.1	5.2	1.5e-07	0.04	1.00	0.00	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	PAIP2B	0.07	0.04	blup	342	0.04	5.6e-06	6.3	6.1	1.2e-09	0.31	0.94	0.00	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	SNRPG	0.03	0.01	blup	225	0.02	2.7e-03	6.0	6.4	1.9e-10	0.02	0.18	0.35	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	PCBP1-AS1	0.08	0.10	bslmm	313	0.10	1.8e-12	-6.3	6.5	7.8e-11	0.00	0.97	0.03	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	ASPRV1	0.06	0.04	bslmm	311	0.06	8.7e-08	-6.3	5.7	1.6e-08	0.02	0.97	0.03	TRUE
44	YFS	Blood	ASPRV1	0.10	0.10	blup	342	0.13	7.7e-40	-6.4	6.6	5.5e-11	-0.01	0.98	0.02	TRUE
45	YFS	Blood	DYSF	0.02	0.01	blup	563	0.01	1.1e-03	8.1	5.9	4.5e-09	0.26	0.22	0.03	TRUE
46	YFS	Blood	MCEE	0.07	0.05	enet	23	0.06	2.5e-19	-5.1	-5.9	3.4e-09	-0.41	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	ANXA4	0.01	0.01	blup	58	0.01	2.3e-03	5.0	5.3	1.4e-07	0.02	0.02	0.82	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	FAM136A	0.03	0.04	lasso	2	0.03	1.3e-07	-5.6	5.6	2.4e-08	0.00	0.03	0.97	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	MCEE	0.03	0.00	blup	66	0.01	1.5e-03	3.9	-5.4	7.4e-08	-0.35	0.10	0.08	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	FAM136A	0.10	0.12	lasso	2	0.12	3.0e-07	-5.6	5.6	2.5e-08	0.00	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Esophageal Carcinoma	ZNF638	0.12	0.08	lasso	1	0.07	2.2e-03	9.7	9.7	4.3e-22	0.76	0.05	0.65	TRUE
52	The Cancer Genome Atlas	Glioblastoma Multiforme	CYP26B1	0.19	0.01	lasso	4	0.00	3.6e-01	3.4	5.3	1.4e-07	0.03	0.03	0.10	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GMCL1	0.03	0.03	blup	46	0.02	5.7e-03	-5.1	-5.2	2.2e-07	-0.04	0.04	0.87	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FAM136A	0.04	0.03	blup	42	0.04	6.0e-05	-5.8	5.2	2.1e-07	-0.01	0.01	0.99	TRUE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FAM136A	0.07	0.03	lasso	3	0.04	1.6e-03	-4.3	5.4	7.8e-08	-0.02	0.02	0.75	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	WDR92	0.04	0.01	blup	49	0.01	7.9e-03	-7.8	-5.7	1.6e-08	-0.03	0.00	0.94	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	FAM136A	0.04	0.03	blup	42	0.03	1.2e-04	-5.6	6.0	1.7e-09	0.01	0.01	0.98	FALSE
58	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ASPRV1	0.08	0.06	enet	14	0.06	2.4e-03	-6.6	6.3	4.0e-10	0.01	0.19	0.16	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	ASPRV1	0.02	0.02	blup	58	0.02	5.4e-03	-6.1	7.1	9.7e-13	0.01	0.21	0.07	FALSE
60	The Cancer Genome Atlas	Soft Tissue Sarcoma	FAM136A	0.08	0.02	enet	4	0.03	8.7e-03	4.8	6.0	2.7e-09	-0.01	0.02	0.50	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	FAM136A	0.04	0.04	lasso	4	0.04	8.5e-04	-5.8	5.9	3.0e-09	-0.01	0.01	0.92	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	ASPRV1	0.06	0.04	blup	58	0.03	4.2e-04	-6.2	5.6	2.3e-08	0.00	0.84	0.04	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	FAM136A	0.05	0.04	lasso	3	0.04	4.5e-05	-5.6	5.8	5.7e-09	0.00	0.01	0.98	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF638	0.08	0.05	enet	10	0.05	5.6e-06	14.2	12.2	2.8e-34	0.88	0.01	0.99	FALSE