TWAS hub - DYSF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1528	0.0457	3.0e-04	0.073	NA	0.072	NA	0.091	7.2e-06	NA	8.0e-06	NA	5.2e-07
2	GTEx	Pituitary	0.4880	0.1020	7.2e-05	0.366	NA	0.453	NA	0.435	4.2e-10	NA	7.7e-13	NA	2.9e-12
3	YFS	Blood	0.0238	0.0095	1.4e-03	0.007	0.008	0.004	0.007	0.004	1.8e-03	0.0011	1.5e-02	0.0012	1.4e-02
4	TCGA	Breast Invasive Carcinoma	0.0326	0.0142	9.6e-03	0.006	0.003	-0.001	NA	0.001	1.6e-02	0.0630	6.8e-01	NA	1.5e-01
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0498	0.0204	1.7e-03	0.027	0.010	0.010	NA	0.012	5.0e-04	0.0230	2.5e-02	NA	1.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Heel bone mineral density (BMD) T-score, automated (left)	4.3	9.8	14.7	-3.8	-2.5	-3.8	-1.4	-3.4
Bipolar Disorder (2018)	3.2	5.1	7.8	2.8	1.0	2.0	2.8	2.2
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.9	10.1	-3.2	-2.6	-3.0	-1.1	-2.8
Medication: Bendroflumethiazide	2.9	4.4	7.7	-2.2	-2.8	-1.6	-0.1	-2.6
Length of working week for main job	2.8	3.1	6.3	-2.2	0.5	-2.5	-1.6	-1.2
Family relationship satisfaction	2.8	3.4	8.2	1.7	1.6	2.9	1.2	1.3
Medication: Seretide 50 evohaler	2.5	2.8	4.6	2.1	-0.4	1.9	2.1	1.2
Pain type(s) experienced in last month: Hip pain	2.5	3.1	6.6	1.7	-0.7	1.9	2.6	1.4
Mouth/teeth dental problems: Bleeding gums	2.3	2.9	4.4	2.0	1.9	-1.0	1.4	2.1
Height	2.1	41.4	85.0	6.5	3.6	9.2	5.0	6.4
Heart disease (siblings)	2.1	2.5	8.8	-0.7	1.7	-0.3	-3.0	-0.8
Waist Hip Ratio (WHR)	1.9	8.7	22.3	-2.7	-1.3	-4.7	-1.6	-3.1
Maternal smoking around birth	1.9	2.8	4.9	1.6	1.5	2.0	0.5	2.2
Type 2 Diabetes (T2D) (2012)	1.8	2.1	5.0	-2.2	-0.2	-0.2	-1.4	-1.9
Father’s age at death	1.8	2.4	5.3	1.0	-0.8	1.5	2.3	1.7
Ever used hormone-replacement therapy (HRT)	1.7	2.1	5.0	-1.9	0.4	-1.2	-0.4	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.7	1.6	-1.8	0.5	1.9	1.1
Supplements: Fish oil (including cod liver oil)	1.7	2.2	8.3	-0.3	1.6	0.2	2.9	-0.4
Schizophrenia vs Biploar Disorder	1.6	2.1	4.9	-2.2	-0.8	-1.5	-0.7	-1.6
Alzheimer’s Disease (in father)	1.6	1.7	4.1	1.1	0.5	2.0	0.9	1.5
Hearing difficulty/problems with background noise	1.6	2.5	8.5	-0.1	2.9	1.6	1.1	0.2
Lung cancer (father)	1.6	1.9	5.8	-1.9	-0.2	0.1	-0.5	-2.4
Pulse wave reflection index	1.6	2.0	3.4	-1.8	-0.1	-0.6	-1.7	-1.8
Average weekly champagne plus white wine intake	1.6	2.2	7.9	-0.0	-2.8	-0.1	1.7	-0.5
Average weekly fortified wine intake	1.5	1.7	4.5	1.0	0.3	0.8	2.1	1.5
Age when periods started (menarche)	1.5	3.6	5.2	2.1	1.5	1.6	2.3	2.0
Medication: Allopurinol	1.5	2.1	2.3	-1.5	-1.2	-1.4	1.4	-1.5
Mineral and other dietary supplements	1.5	2.0	7.2	0.8	-1.1	-0.4	-2.7	0.8
Hearing difficulty/problems: Yes	1.4	2.1	6.3	-0.8	1.8	2.5	0.2	-0.4
Standing height	1.4	14.3	34.5	2.9	3.1	5.9	2.6	3.5
Age at first live birth	1.4	2.4	5.1	2.0	0.7	0.8	1.4	2.3
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.8	-1.6	0.4	-1.7	-1.0	-1.5
Heel T-Score	1.3	10.4	27.2	-1.9	-4.2	-5.2	-0.4	-2.0
Supplements: Glucosamine	1.3	1.7	4.5	-2.1	0.5	0.4	0.7	-1.8
Had menopause	1.3	1.6	2.5	-1.1	-1.6	-1.0	-1.0	-1.4
Medication: Ramipril	1.3	1.6	3.8	-1.1	0.9	-0.0	-1.9	-1.5
Loud music exposure frequency	1.3	1.4	3.7	-1.1	0.8	-0.6	-1.9	-1.2
Illnesses of father: Heart disease	1.3	1.8	3.5	0.5	1.3	-1.9	-1.8	0.5
Breast cancer (self-reported)	1.3	1.5	2.6	1.2	1.3	1.6	-0.8	1.0
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.3	1.1	1.2	0.6	1.8	1.2
Medication: Blood pressure	1.3	2.5	3.9	-1.8	-1.1	-1.1	-1.7	-2.0
Bipolar Disorder or Schizophrenia	1.2	3.0	6.7	1.9	0.6	1.6	2.6	1.4
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.4	-0.9	-1.4	-1.7	-0.1	-1.9
Number of full brothers	1.2	1.5	3.7	-0.5	-1.9	-1.6	0.4	-0.8
Had major operations	1.2	1.4	5.6	-0.1	2.4	-0.2	-1.1	0.0
Friendships satisfaction	1.2	1.5	3.2	0.5	1.8	1.4	1.4	0.2
Osteoporosis (self-reported)	1.2	1.5	2.6	1.6	0.4	1.2	1.2	1.3
Commuting to job workplace: Public transport	1.2	1.4	2.5	1.2	0.9	1.3	0.9	1.6
Age started oral contraceptive pill	1.2	1.5	3.3	-0.3	0.9	1.8	1.8	0.1
Alzheimer’s Disease (including proxy)	1.1	1.6	3.0	1.7	0.9	1.2	0.3	1.7
Ovarian Cancer	1.1	1.5	2.5	-1.6	-1.0	0.7	-1.0	-1.6
Relative age of first facial hair	1.1	2.2	6.7	-0.2	2.6	1.6	-0.7	1.0
Vitamin and mineral supplements	1.1	1.5	3.5	1.0	-0.4	-1.9	-1.3	0.9
Supplements: Zinc	1.1	1.2	3.8	-0.2	1.1	1.9	0.9	-0.3
Multivitamins +/- minerals	1.1	1.4	4.7	-0.2	0.8	2.2	1.1	0.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	5.8	0.3	0.2	-2.4	0.6	-0.3
Sitting height	1.1	7.6	25.6	1.7	1.5	5.1	1.1	2.4
Number of children fathered	1.1	1.2	2.3	-1.4	-1.5	-0.3	0.4	-1.2
Pulse wave peak to peak time	1.1	1.3	3.3	1.1	0.7	1.8	0.2	1.2
Miserableness	1.1	1.9	3.7	-1.3	-1.3	-1.2	-1.1	-1.9
Major Depression (MDD)	1.0	1.2	3.9	0.9	1.0	0.4	2.0	0.4
Blood Eosinophil Count	1.0	7.6	12.4	3.2	1.6	2.3	2.7	3.5
Lung FEV1/FVC ratio	1.0	5.1	10.7	3.0	2.0	-1.4	-0.2	3.3
Frequency of depressed mood in last 2 weeks	1.0	1.3	4.1	2.0	0.3	0.4	0.7	1.3
Relative age voice broke	1.0	1.6	6.5	0.6	2.6	-0.1	-0.8	0.7
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.4	-1.9	-0.1	-0.1	-1.0	-1.4
Illnesses of mother	1.0	1.2	5.3	0.4	0.7	-0.5	-2.3	-0.1
Headache pain in last month	1.0	1.6	3.8	0.9	1.3	-0.9	-1.9	1.0
Glaucoma (self-reported)	1.0	1.1	2.5	-0.3	1.6	0.1	1.6	-0.8
Gout (self-reported)	1.0	1.3	2.5	-0.9	-0.1	-1.6	1.3	-1.2
Birth weight	1.0	2.3	5.2	-2.2	-0.4	0.8	-0.3	-2.3
Forced vital capacity (FVC), Best measure	1.0	3.8	10.8	-0.1	2.7	3.3	0.2	1.0
Comparative height size at age 10	1.0	5.3	11.8	2.2	1.2	3.4	1.5	2.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	7.2	0.5	1.4	2.7	0.4	1.1
Medication for cholesterol	1.0	1.5	3.3	1.4	1.8	0.5	0.1	1.3
Eye problems/disorders: Glaucoma	1.0	1.1	2.9	-1.0	0.9	-0.1	1.0	-1.7
Number of operations (self-reported)	1.0	1.5	6.2	0.3	2.5	-0.4	-1.1	0.2
Basal cell carcinoma (self-reported)	1.0	1.2	3.5	0.7	1.1	-1.9	-0.9	0.6
HbA1C	0.9	1.0	1.8	1.1	0.1	-1.3	0.2	1.3
Average weekly spirits intake	0.9	1.1	3.4	-0.4	0.6	-0.9	1.8	-0.9
Medication for hormone replacement therapy	0.9	1.0	1.8	-1.3	-1.3	-0.4	0.3	-1.1
Diabetes (mother)	0.9	1.1	2.7	1.7	0.8	0.6	0.3	1.3
Hand grip strength (right)	0.9	2.4	4.8	1.5	1.7	2.2	-0.3	1.4
Current tobacco smoking	0.9	1.5	3.1	1.4	-1.7	1.2	0.7	0.7
Nervous feelings	0.9	1.6	3.4	-1.1	-0.5	-1.8	-0.1	-1.8
Worrier / anxious feelings	0.9	1.7	5.9	0.9	2.4	0.3	0.9	1.1
Breastfed as a baby	0.9	1.2	3.3	1.3	0.2	0.9	-0.0	1.8
Medication: Amlodipine	0.9	1.3	2.1	1.4	-0.2	1.4	0.9	1.3
Emphysema/chronic bronchitis	0.9	1.1	4.6	0.2	-0.5	2.1	-0.6	-0.3
Neck or shoulder pain in last month	0.9	1.2	2.0	0.9	0.7	1.2	-1.4	1.2
Arm predicted mass (right)	0.9	4.5	11.5	1.6	2.2	3.4	0.3	1.8
Ever had bowel cancer screening	0.9	1.0	2.7	-0.2	0.5	-1.6	-1.4	-0.3
Osteoarthritis (self-reported)	0.9	1.2	2.5	-1.0	-1.2	-1.6	-0.3	-1.0
Hearing aid user	0.9	1.0	2.6	-1.6	0.8	0.9	-0.2	-1.0
Financial situation satisfaction	0.9	1.1	2.5	-1.5	0.4	-0.7	-0.6	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	1.8	-1.2	-1.2	-0.7	-0.5	-1.4
Crohns Disease (2012)	0.8	1.3	5.8	0.5	2.4	0.7	-0.1	0.0
Fasting Glucose	0.8	0.9	2.1	-1.4	1.1	0.3	-0.6	-0.9
LDL Cholesterol	0.8	1.2	4.9	-0.5	0.8	-0.7	-2.2	-0.0
Chronotype (morning person)	0.8	1.8	6.9	-0.9	0.4	-2.6	-1.0	-0.6
Chronic bronchitis/emphysema (father)	0.8	0.9	1.6	-1.0	-1.2	-0.4	-0.7	-1.3
High blood pressure (mother)	0.8	1.2	3.4	0.2	-1.1	-1.0	1.9	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.4	-0.7	1.9	0.1	0.7	-0.4
Prospective memory result	0.8	1.0	1.9	1.4	0.9	-0.6	0.5	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	7.8	0.0	2.8	1.8	-0.3	1.1
Exposure to tobacco smoke at home	0.8	0.9	2.0	-0.8	0.7	-1.0	-1.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	5.0	-0.1	-0.5	-0.9	2.2	-0.6
Arm fat-free mass (right)	0.8	4.1	11.0	1.4	2.3	3.3	0.4	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.4	-0.1	-1.6	-1.2	0.9	0.2
Medication: Gliclazide	0.8	0.9	1.7	1.3	-1.0	0.1	1.0	0.9
Ever depressed for a whole week	0.8	1.0	1.8	-1.0	1.0	0.6	-1.3	-1.0
Depression (Nagel 2018)	0.7	1.1	3.9	2.0	0.3	0.4	-0.2	1.1
Reaction Time	0.7	1.3	4.7	0.5	2.2	0.9	-0.8	0.2
Bipolar Disorder (2011)	0.7	0.7	3.1	0.5	-0.0	1.8	0.0	0.0
Rheumatoid Arthritis	0.7	1.0	2.5	-1.0	-0.6	-0.3	-0.9	-1.6
Ulcerative Colitis	0.7	1.0	1.7	-1.0	1.3	1.0	-0.6	-0.8
Hand grip strength (left)	0.7	1.9	3.0	1.4	1.7	1.4	0.4	1.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.8	-0.4	1.9	-0.1	0.2	-0.7
Ever had hysterectomy (womb removed)	0.7	0.8	1.3	-1.1	0.5	0.6	0.9	-1.1
Diabetes (father)	0.7	0.9	3.4	0.2	1.8	0.7	0.3	-0.6
Medication: Atenolol	0.7	0.8	2.7	-0.9	0.2	-0.6	-1.6	-0.5
Medication: Levothyroxine sodium	0.7	1.1	2.6	-0.9	-1.0	-0.6	-1.6	-1.0
Number of incorrect matches in round	0.7	1.2	1.6	1.3	1.1	-0.2	-1.1	1.3
Hair/balding pattern: Pattern 2	0.7	0.9	2.0	-0.5	-0.9	-1.3	1.4	0.1
Mouth/teeth dental problems	0.7	1.0	2.7	-0.7	-1.6	0.7	-0.9	-0.8
Comparative body size at age 10	0.7	1.9	6.0	-0.6	-1.1	-2.4	-0.9	-1.0
Worry too long after embarrassment	0.7	1.2	2.2	1.5	0.8	-0.9	0.5	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.3	0.9	0.9	1.1	0.4	1.2
Shortness of breath walking on level ground	0.7	0.8	2.2	-0.8	-0.2	-1.0	-1.5	0.0
Medication: Ibuprofen	0.7	0.8	1.6	0.4	-0.0	-1.2	0.8	1.2
Back pain experienced in last month	0.7	1.1	2.8	0.4	1.7	-0.3	-1.1	1.1
Smoking status: Current	0.7	1.2	2.9	1.3	-1.7	0.9	0.8	0.3
Guilty feelings	0.7	1.1	2.3	1.0	-0.9	-1.0	1.5	0.6
Irritability	0.7	1.3	2.3	-1.0	-0.4	-1.5	-0.9	-1.4
Unable to work because of sickness or disability	0.7	0.9	3.6	0.3	-1.9	0.1	0.9	-0.3
Supplements: Calcium	0.7	0.8	3.1	-0.5	1.7	0.3	-0.5	0.5
Age at First Birth	0.6	0.9	1.7	0.1	-1.3	-0.9	-0.9	-1.1
Neuroticism (2016)	0.6	0.9	1.9	-0.9	-0.4	-0.8	1.4	-1.1
Schizophrenia (2014)	0.6	1.2	3.8	0.8	0.9	0.6	1.9	0.7
Systolic Blood Pressure	0.6	3.0	5.9	-1.8	-2.2	-0.3	-1.0	-2.4
Allergy or Eczema	0.6	1.5	5.2	-0.6	-0.9	0.1	2.3	-1.2
Stomach or abdominal pain in last month	0.6	0.8	1.6	-1.0	0.1	-0.4	-1.3	-1.0
Forced vital capacity (FVC)	0.6	2.1	8.0	-0.0	1.4	2.8	0.2	0.9
Pain all over the body in last month	0.6	0.7	2.0	-0.5	-0.3	1.4	0.3	-1.0
Medication: Simvastatin	0.6	0.8	3.1	0.1	-1.8	0.3	1.0	0.0
Arm fat percentage (right)	0.6	2.5	6.7	-1.6	-1.3	-2.6	-0.6	-1.1
Trunk fat-free mass	0.6	3.5	8.2	1.2	2.4	2.9	0.8	1.2
Happiness	0.6	0.8	1.7	1.3	1.1	0.1	0.3	1.0
Noisy workplace	0.6	0.7	1.3	1.1	0.9	0.3	0.6	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.2	0.1	-0.7	-1.5	0.7	0.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.8	-0.8	-0.4	-1.4	-0.1	-0.9
Trunk predicted mass	0.6	3.6	8.4	1.2	2.5	2.9	0.8	1.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	-0.6	1.4	0.2	-1.0	-0.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.8	0.4	0.3	1.3	1.3	0.8
Blood clot in the leg (DVT)	0.6	0.8	1.0	-0.9	-1.0	-0.9	-0.8	-0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	-1.1	1.2	0.7	-0.5	-0.3
Exposure to tobacco smoke outside home	0.6	0.8	1.7	-1.3	0.2	-0.1	-1.0	-1.2
Qualifications: College or University degree	0.6	1.8	4.2	0.9	-0.3	1.3	2.0	1.5
Eye problems/disorders: None of the above	0.6	0.7	1.7	1.0	-0.8	-0.2	0.3	1.3
Age at last live birth	0.6	0.8	1.3	1.1	-0.7	0.8	0.8	1.1
Hypertension (Self-reported)	0.6	1.8	3.9	-1.4	0.1	-0.5	-2.0	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.2	0.8	1.5	-0.2	-0.6	0.5
Qualifications: nursing, teaching	0.6	0.9	2.2	1.1	0.9	0.2	0.3	1.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.9	1.0	0.4	0.6	1.4	1.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.6	-1.0	-1.3	0.3	0.4	-0.8
Medication: Atorvastatin	0.6	0.7	1.9	0.4	-1.4	-1.1	-0.6	0.1
Arm fat-free mass (left)	0.6	3.2	6.9	1.4	2.1	2.6	0.5	1.6
Arm predicted mass (left)	0.6	3.0	6.6	1.3	1.9	2.6	0.5	1.6
Body Mass Index (BMI) (2010)	0.5	0.7	1.5	-1.2	0.5	0.0	-0.6	-1.2
Primary Biliary Cirrhosis	0.5	0.8	2.1	1.0	-0.4	0.6	1.5	0.3
Blood White Count	0.5	3.9	8.1	2.5	-0.5	0.5	2.2	2.8
Severe depression (siblings)	0.5	0.5	1.3	-0.6	-0.2	-1.1	-1.0	-0.1
Impedance of leg (right)	0.5	2.2	6.7	1.6	-0.9	-0.6	0.7	2.6
Impedance of leg (left)	0.5	2.4	8.1	1.8	-0.4	0.4	0.6	2.9
Number of live births	0.5	0.7	1.7	1.3	-0.4	0.6	0.4	1.0
Medication: Cholesterol lowering	0.5	0.8	2.5	-0.6	-1.6	0.2	0.7	-0.7
Medication: Lansoprazole	0.5	0.6	1.4	-0.2	0.5	0.3	-1.2	-1.1
Peak expiratory flow (PEF)	0.5	1.2	3.1	0.9	0.4	1.3	0.0	1.7
Alcohol intake frequency.	0.5	1.3	4.5	0.3	-0.4	-2.1	-1.2	0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.6	1.3	0.2	0.7	0.2	0.8
Whole body fat-free mass	0.5	3.1	8.8	0.8	2.3	3.0	0.6	0.8
Arm fat percentage (left)	0.5	2.1	4.9	-1.6	-1.0	-2.2	-0.9	-1.1
Loneliness, isolation	0.5	0.7	1.6	1.1	1.2	-0.1	0.4	0.7
Long-standing illness, disability or infirmity	0.5	0.8	1.8	-0.6	-1.1	-0.1	0.8	-1.4
Whole body water mass	0.5	3.1	8.1	0.8	2.3	2.8	0.6	0.8
Medication: Lisinopril	0.5	0.6	1.7	-0.2	-1.3	0.7	-0.0	-0.9
Illnesses of father: High blood pressure	0.5	0.6	1.2	-0.4	1.1	-0.9	-0.9	0.5
Commuting to job workplace: Cycle	0.5	0.5	1.8	0.0	1.4	-0.0	-0.9	0.1
Myopia	0.5	0.7	1.9	1.4	-0.0	1.1	-0.0	0.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.6	1.0	0.6	0.4	1.9	1.1
Coronary Artery Disease (CAD)	0.4	0.4	0.7	0.7	0.7	-0.2	-0.9	0.7
Triglycerides	0.4	0.6	1.6	0.2	-0.2	-1.1	-1.3	0.3
Cardiovascular Disease	0.4	1.2	2.8	-0.9	-0.8	-1.7	-0.7	-1.1
Respiratory disease	0.4	0.8	1.7	-0.7	0.8	1.3	0.1	-1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	2.0	-0.1	-0.5	-0.1	-1.4	0.1
Angina	0.4	0.5	1.4	0.7	-1.2	-0.2	-0.6	0.6
Taking other prescription medications	0.4	0.6	2.2	-0.8	0.4	-0.2	-0.3	-1.5
High blood pressure	0.4	1.1	2.9	-1.1	0.0	-0.2	-1.7	-1.3
Waist circumference	0.4	1.5	3.8	-1.1	-0.6	-1.9	-1.0	-1.0
Hair/balding pattern: Pattern 3	0.4	0.7	1.8	1.0	0.0	1.3	-0.2	0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.8	-0.0	1.7	1.6	-0.3	0.9
Depression (self-reported)	0.4	0.4	1.5	0.2	0.5	-0.6	-1.2	-0.2
Medication: Paracetamol	0.4	0.6	1.7	0.7	-1.3	-0.6	0.8	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.1	-0.7	-1.0	-0.5	-1.0	-0.9
High blood pressure (siblings)	0.4	0.5	1.0	1.0	-0.3	0.7	0.3	0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	1.4	-1.2	0.7	0.8	-0.6	-0.9
Medication: Omeprazole	0.4	0.5	0.8	0.9	0.8	-0.1	0.2	0.9
Mean time to correctly identify matches	0.4	0.8	1.4	0.5	1.2	1.2	-1.0	-0.2
Heart disease (mother)	0.4	0.5	1.3	-0.5	-0.7	0.8	1.1	-0.3
Leg pain on walking	0.4	0.5	2.4	-0.0	-0.3	-1.5	-0.2	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.9	0.0	-1.4	-0.3	-0.6	0.1
Leg fat-free mass (right)	0.4	2.3	7.3	-0.2	2.0	2.7	0.1	-0.1
Asthma (self-reported)	0.4	0.9	2.4	-1.2	0.1	0.5	0.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.0	-0.3	1.7	0.0	0.7	1.0
Leg predicted mass (right)	0.4	2.2	7.1	-0.3	1.9	2.7	0.1	-0.1
Ever taken oral contraceptive pill	0.4	0.4	1.7	0.1	-0.2	1.3	0.6	0.2
Medication: Paracetamol	0.4	0.5	1.3	0.7	-1.2	-0.1	0.8	0.3
Alcohol drinker status: Never	0.4	0.5	0.7	-0.8	-0.1	-0.8	-0.8	-0.6
Basal metabolic rate	0.4	2.3	5.9	0.6	2.1	2.4	0.3	0.8
Average weekly beer plus cider intake	0.4	0.5	1.9	-0.6	1.4	0.1	-0.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	-0.0	1.0	-0.7	-1.0	0.4
Alcohol drinker status: Previous	0.4	0.5	1.1	-0.7	0.1	-0.9	-1.1	-0.2
Pack years of smoking	0.4	0.6	1.8	-0.6	-0.9	1.4	0.2	0.1
Worry (Nagel 2018)	0.3	0.7	1.3	-0.9	-1.0	-0.2	0.2	-1.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	0.6	0.5	-0.3	-0.5	0.7
Crohns Disease (2017)	0.3	0.6	2.5	-0.3	1.6	-0.1	-0.1	-0.6
Ulcerative Colitis (UC)	0.3	0.5	0.9	-1.0	0.5	0.7	-0.8	-0.5
Blood Platelet Count	0.3	3.6	8.4	2.9	1.3	1.1	0.9	2.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.8	0.0	-1.4	-1.1	-0.2	-0.3
Medication: Co-codamol	0.3	0.4	0.7	0.3	-0.7	0.7	0.8	-0.4
Pack years adult smoking proportion	0.3	0.5	1.3	-0.4	-0.9	1.2	0.0	0.4
Leg fat-free mass (left)	0.3	1.5	4.6	-0.1	1.7	2.1	0.2	0.1
Townsend deprivation index at recruitment	0.3	0.4	1.4	0.4	0.5	-1.2	-0.2	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.7	0.8	-0.2	-0.9	0.1
Qualifications: CSEs or equivalent	0.3	0.4	2.0	0.1	1.4	0.3	-0.2	0.1
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.7	-0.2	-0.2	0.1	1.6	-0.3
Body mass index (BMI)	0.3	1.4	2.7	-1.2	-0.4	-1.6	-1.2	-1.0
Leg predicted mass (left)	0.3	1.5	4.5	-0.2	1.7	2.1	0.1	0.0
Past tobacco smoking	0.3	0.6	1.4	-0.5	-0.9	-0.3	-1.2	-0.4
Alcohol usually taken with meals	0.3	0.5	2.4	-0.1	-0.0	1.5	-0.3	-0.1
Allergy	0.3	0.8	2.1	1.0	0.3	-0.4	-0.8	1.5
Time employed in main current job	0.3	0.3	0.9	0.3	0.6	0.9	-0.4	0.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	0.1	0.5	-0.9	-1.1	-0.4
Asthma	0.3	0.6	1.5	-0.9	-0.0	0.5	0.5	-1.2
Tense / ‘highly strung’	0.3	0.5	1.2	0.6	-1.1	-0.8	0.5	-0.5
Birth weight of first child	0.3	0.5	1.2	1.1	0.9	0.2	0.5	0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	0.1	-0.9	0.1	0.7	-0.8
Leg fat percentage (right)	0.3	0.9	3.0	0.4	-0.5	-1.7	-0.6	0.9
Wheeze or whistling in the chest in last year	0.3	0.5	1.2	-0.3	-0.6	0.8	-0.3	-1.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.2	1.1	0.2	0.5	0.2	0.6
Angina (self-reported)	0.3	0.4	0.7	0.6	-0.7	-0.3	-0.8	0.5
Migraine (self-reported)	0.3	0.4	0.7	-0.1	-0.8	-0.7	0.1	-0.8
Number of full sisters	0.3	0.3	0.9	0.3	-0.2	0.8	-1.0	-0.2
Suffer from ‘nerves’	0.3	0.5	1.4	0.2	-1.2	0.3	0.9	-0.2
Overall health rating	0.3	0.6	1.3	0.6	-0.9	-0.7	-1.1	0.0
Supplements: Vitamin C	0.3	0.3	0.5	-0.6	0.1	0.7	0.5	-0.7
Knee pain experienced in last month	0.3	0.5	1.2	-0.2	-1.0	-1.1	0.0	-0.7
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.6	0.9	0.9	-0.1	0.2
Smoking status: Previous	0.3	0.4	1.5	-0.1	0.6	0.2	1.2	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.8	-0.3	-0.1	-1.3	-0.3	0.1
Eye problems/disorders: Cataract	0.3	0.4	0.7	-0.8	0.2	0.0	-0.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	0.1	-0.8	-0.9	-0.6	-0.5
Wears glasses or contact lenses	0.3	0.4	0.9	0.5	-0.9	0.7	-0.4	0.4
High cholesterol (Self-reported)	0.3	0.5	1.2	-0.0	-0.9	-0.3	1.1	-0.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.0	-0.2	0.9	0.0	1.0	-0.1
Pain experienced in last month	0.3	0.6	1.5	-0.8	0.0	0.8	0.1	-1.2
Irritable Bowel Disease (IBD)	0.2	0.6	2.2	-0.5	1.5	0.3	-0.5	-0.2
Breast Cancer	0.2	0.6	2.1	-0.1	-1.4	0.2	0.3	-0.8
Prostate Cancer	0.2	0.3	0.7	-0.0	0.3	0.4	0.8	-0.6
Mean Putamen Volume	0.2	0.2	0.4	-0.5	0.2	0.5	-0.7	0.1
HDL Cholesterol	0.2	0.4	0.8	-0.9	-0.2	0.9	-0.0	-0.7
Lupus	0.2	0.3	0.7	-0.1	0.9	0.1	0.7	-0.2
BMI	0.2	1.3	5.7	-0.0	-0.2	-2.4	-0.9	0.1
Smoking Status	0.2	0.6	1.0	1.0	-0.3	0.9	0.7	0.6
Hypothyroidism (self reported)	0.2	0.4	0.6	0.7	-0.8	0.4	-0.5	0.5
Lung FVC	0.2	1.2	3.0	-1.7	-0.6	0.5	0.0	-1.6
Neuroticism	0.2	0.5	0.9	-1.0	-0.0	-0.8	0.4	-0.8
Sensitivity / hurt feelings	0.2	0.3	1.0	0.4	1.0	0.2	0.6	0.2
Fed-up feelings	0.2	0.3	0.9	-0.3	1.0	0.3	-0.3	-0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.8	-0.1	0.3	-0.4	-0.0	-0.9
Had other major operations	0.2	0.2	0.7	0.6	-0.8	0.3	-0.1	-0.2
Qualifications: None of the above	0.2	0.4	1.0	0.0	-1.0	-0.9	-0.2	-0.5
Financial difficulties in last 2 years	0.2	0.3	0.5	0.5	0.5	0.5	0.7	-0.1
Heart attack	0.2	0.3	0.6	-0.2	0.2	-0.7	-0.8	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	0.6	0.0	-0.6	-0.1	0.8
Illnesses of siblings	0.2	0.3	0.6	0.0	0.4	-0.1	0.8	0.8
Neuroticism score	0.2	0.4	0.9	-0.6	0.4	-0.5	0.1	-1.0
Impedance of arm (right)	0.2	0.8	2.0	-0.8	-0.9	-1.4	0.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.9	0.8	0.5	1.0	0.0	-0.0
Falls in the last year	0.2	0.3	0.8	-0.1	0.3	0.1	-0.9	-0.8
Pulse rate	0.2	0.3	0.8	-0.5	-0.3	-0.9	0.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.6	-0.2	0.2	0.5	1.3	0.5
Arm fat mass (right)	0.2	0.7	1.4	-1.1	0.1	-1.2	-0.7	-0.5
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	0.3	1.0	-0.8	-0.4	0.2
Health satisfaction	0.2	0.3	0.5	-0.3	-0.7	-0.4	-0.7	-0.6
Chest pain or discomfort	0.2	0.2	0.5	0.7	0.3	0.7	-0.1	0.4
Medication: Aspirin	0.2	0.3	0.7	0.3	-0.4	0.9	0.5	0.4
Commuting to job workplace: Walk	0.2	0.2	0.7	-0.8	0.2	-0.0	0.1	-0.7
Arm fat mass (left)	0.2	0.6	1.1	-1.0	0.1	-1.0	-0.9	-0.5
Mother’s age at death	0.2	0.3	0.5	-0.7	0.2	-0.7	0.1	-0.6
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.1	-0.6	-0.5	-0.3	-0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	-0.2	0.0	-0.8	-0.5	-0.4
Impedance of whole body	0.2	0.8	2.3	0.6	-1.0	-0.1	0.6	1.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	-0.3	0.8	0.3	0.0	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	0.2	-0.8	0.1	0.9	0.2
Schizophrenia (2018)	0.1	0.3	1.0	0.3	0.1	0.4	1.0	0.0
Number of treatments/medications taken	0.1	0.2	0.4	0.5	-0.4	0.4	0.7	0.4
Systolic blood pressure, automated reading	0.1	0.3	1.1	0.0	-1.0	0.3	0.3	-0.6
Medication: Metformin	0.1	0.1	0.4	0.1	0.2	-0.6	0.2	-0.2
Trunk fat percentage	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.0	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.6	0.2	0.3	-0.3	-0.0
Serious illness, injury or assault to yourself	0.1	0.2	0.7	-0.0	-0.3	-0.3	0.8	-0.2
Diabetes (self-reported)	0.1	0.1	0.4	-0.1	0.0	-0.6	-0.3	-0.3
Fluid intelligence score	0.1	0.2	0.5	-0.3	0.1	-0.1	-0.7	-0.5
Weight	0.1	0.4	1.0	0.2	0.9	1.0	0.1	0.6
Hip circumference	0.1	0.5	1.3	0.5	1.1	0.8	0.0	0.8
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.6	0.6	-0.6	0.1	-0.2
Impedance of arm (left)	0.1	0.4	0.8	-0.8	-0.9	-0.8	0.3	-0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.1	0.6	-0.4	-0.5	0.3
Body fat percentage	0.1	0.4	1.0	-0.0	-0.6	-1.0	-0.1	0.8
Medication: Blood pressure	0.1	0.2	0.6	0.1	-0.0	0.7	0.6	0.1
Whole body fat mass	0.1	0.2	0.9	0.3	0.4	-0.1	-0.1	1.0
Leg fat mass (right)	0.1	0.4	0.9	0.4	0.4	-0.6	-0.6	0.9
Pulse rate, automated reading	0.1	0.4	1.1	0.6	-1.1	-0.5	0.7	0.1
Average weekly red wine intake	0.1	0.2	0.6	-0.1	-0.3	0.8	0.1	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.5	0.1	-0.7	-0.2	0.3	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.3	-0.2	0.4	0.4	-0.6
Medication: Aspirin	0.1	0.1	0.5	0.0	-0.2	0.7	0.4	0.0
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	0.2	-0.2	-0.5	-0.3	-0.4
Ever smoked	0.1	0.2	0.6	0.0	0.6	0.4	0.8	0.2
Leg fat percentage (left)	0.1	0.5	1.1	0.4	-0.4	-1.0	-0.5	0.9
Risk taking	0.1	0.2	0.4	-0.2	0.6	-0.6	-0.4	-0.4
Diastolic blood pressure, automated reading	0.1	0.3	1.3	0.3	-0.6	-1.1	-0.1	0.0
Cholesterol lowering medication	0.1	0.1	0.3	0.2	0.5	-0.3	-0.0	0.1
Leg fat mass (left)	0.1	0.2	0.5	0.2	0.3	-0.4	-0.6	0.7
Neuroticism (Nagel 2018)	0.0	0.1	0.2	-0.2	-0.2	-0.4	0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.1	-0.4	0.5	0.3	0.0
Blood Red Count	0.0	0.4	1.0	-1.0	-0.4	-0.3	0.8	-0.3
Hair Pigment	0.0	0.5	1.0	0.7	1.0	0.4	-0.3	1.0
Tanning	0.0	0.5	1.0	0.8	-0.2	0.1	1.0	0.9
Trunk fat mass	0.0	0.2	0.8	0.0	0.1	0.3	0.3	0.9
Mood swings	0.0	0.1	0.2	0.2	0.0	0.0	0.2	-0.4

Hub : Genes

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Trait associations