[Hub]/) : Traits : Vascular/heart problems diagnosed by doctor : ← →

chr8:8,092,025-13,120,332

Best TWAS P=1.09e-13 · Best GWAS P=1.54e-13 conditioned to 0.00178

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
59	NTR	Blood	MSRA	0.02	0.01	blup	833	0.01	2.3e-05	-4.4	7.4	1.1e-13	-0.62	0.71	0.28	TRUE
60	NTR	Blood	NEIL2	0.04	0.03	lasso	5	0.02	3.0e-07	-6.5	-6.5	8.9e-11	0.33	0.00	1.00	TRUE
28	GTEx	Esophagus Gastroesophageal Junction	MSRA	0.11	-0.01	enet	30	-0.01	8.0e-01	-5.2	7.1	9.3e-13	-0.42	0.18	0.11	FALSE
48	GTEx	Prostate	AF131215.2	0.18	0.02	lasso	6	0.02	9.6e-02	-5.4	-6.8	7.6e-12	0.82	0.09	0.44	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	XKR6	0.11	0.10	enet	23	0.13	1.2e-16	4.8	-6.5	1.1e-10	0.62	0.99	0.01	FALSE
42	GTEx	Muscle Skeletal	NEIL2	0.11	0.08	lasso	5	0.05	4.7e-06	-6.5	-6.4	1.2e-10	0.39	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	ERI1	0.05	0.00	enet	10	0.00	5.5e-01	-5.3	6.3	2.2e-10	-0.46	0.11	0.69	FALSE
9	GTEx	Artery Aorta	FDFT1	0.09	0.02	lasso	4	0.03	6.1e-03	-4.5	-6.3	2.6e-10	0.49	0.18	0.35	FALSE
25	GTEx	Cells Transformed fibroblasts	ERI1	0.34	0.35	lasso	7	0.35	1.9e-27	-5.5	6.3	2.6e-10	-0.49	0.05	0.95	FALSE
43	GTEx	Nerve Tibial	ERI1	0.07	0.01	enet	16	0.01	4.2e-02	4.9	6.3	3.2e-10	-0.48	0.05	0.87	FALSE
15	GTEx	Artery Tibial	ERI1	0.05	0.02	lasso	7	0.01	3.2e-02	-5.6	6.2	5.7e-10	-0.51	0.03	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM86B1	0.02	0.02	lasso	3	0.01	1.3e-02	-5.7	-6.2	6.0e-10	0.52	0.18	0.51	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	RP1L1	0.02	0.01	lasso	2	0.01	4.1e-03	-5.4	-6.1	1.1e-09	0.52	0.01	0.81	FALSE
37	GTEx	Heart Atrial Appendage	AF131215.9	0.24	0.17	enet	26	0.18	1.3e-08	4.7	-6.0	1.7e-09	0.57	0.99	0.01	FALSE
32	GTEx	Esophagus Muscularis	ERI1	0.12	0.09	enet	13	0.08	7.7e-06	-5.9	6.0	2.0e-09	-0.51	0.01	0.99	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NEIL2	0.05	0.07	enet	5	0.08	8.1e-09	-5.4	-6.0	2.0e-09	0.37	0.00	1.00	FALSE
54	GTEx	Stomach	AF131215.9	0.14	0.06	enet	19	0.06	6.7e-04	4.7	-6.0	2.4e-09	0.54	0.74	0.07	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LOC100506990	0.08	0.03	enet	32	0.05	4.1e-07	-5.7	-5.9	4.5e-09	0.48	0.19	0.80	FALSE
16	GTEx	Artery Tibial	NEIL2	0.21	0.07	enet	18	0.13	2.8e-10	-5.5	-5.8	5.3e-09	0.35	0.22	0.78	FALSE
24	GTEx	Breast Mammary Tissue (Female)	AF131215.9	0.04	-0.01	enet	6	0.02	7.3e-02	4.2	-5.8	6.1e-09	0.59	0.08	0.15	FALSE
40	GTEx	Lung	ERI1	0.13	0.07	lasso	6	0.09	2.7e-07	5.0	5.8	6.6e-09	-0.52	0.27	0.73	FALSE
34	GTEx	Esophagus Muscularis	AF131215.9	0.14	0.17	enet	16	0.17	1.6e-10	4.7	-5.8	7.0e-09	0.63	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	NEIL2	0.12	0.14	enet	19	0.14	3.3e-11	-5.5	-5.8	7.1e-09	0.36	0.12	0.88	FALSE
56	GTEx	Thyroid	AF131215.2	0.11	0.15	enet	17	0.18	1.2e-13	4.7	-5.8	7.1e-09	0.63	1.00	0.00	FALSE
10	GTEx	Artery Aorta	ERI1	0.11	0.08	lasso	5	0.10	5.1e-06	-5.5	5.7	9.9e-09	-0.51	0.02	0.98	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	AF131215.2	0.13	0.06	enet	10	0.11	6.4e-05	-4.6	-5.7	1.1e-08	0.62	0.56	0.04	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	AF131215.3	0.08	0.10	lasso	7	0.12	8.3e-16	-5.1	-5.7	1.1e-08	0.65	1.00	0.00	FALSE
27	GTEx	Colon Transverse	RP11-375N15.2	0.09	0.10	lasso	5	0.07	2.4e-04	-4.8	-5.7	1.3e-08	0.31	0.15	0.81	FALSE
8	GTEx	Adrenal Gland	AF131215.9	0.18	0.16	lasso	10	0.18	3.5e-07	-4.8	-5.6	1.9e-08	0.63	0.96	0.01	FALSE
14	GTEx	Artery Coronary	AF131215.2	0.11	0.02	enet	27	0.05	6.5e-03	5.0	-5.6	1.9e-08	0.64	0.10	0.56	FALSE
31	GTEx	Esophagus Mucosa	AF131215.9	0.18	0.16	lasso	14	0.19	1.6e-12	-5.3	-5.6	2.0e-08	0.65	1.00	0.00	FALSE
23	GTEx	Breast Mammary Tissue	AF131215.9	0.10	0.10	lasso	8	0.12	8.7e-07	5.0	-5.6	2.3e-08	0.69	0.82	0.16	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	FAM85A	0.11	0.07	enet	23	0.11	4.3e-14	-5.3	-5.6	2.5e-08	0.49	0.29	0.71	FALSE
52	GTEx	Spleen	AF131215.2	0.16	0.08	enet	14	0.06	1.1e-02	4.7	-5.6	2.7e-08	0.63	0.34	0.18	FALSE
58	GTEx	Uterus	AF131215.9	0.16	-0.01	enet	18	0.03	7.5e-02	-5.0	-5.6	2.7e-08	0.60	0.13	0.45	FALSE
46	GTEx	Ovary	NEIL2	0.47	0.32	lasso	7	0.26	5.7e-07	-5.5	-5.6	2.8e-08	0.32	0.01	0.98	FALSE
45	GTEx	Nerve Tibial	AF131215.2	0.19	0.18	lasso	12	0.23	3.5e-16	4.7	-5.5	3.0e-08	0.65	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	ERI1	0.06	0.04	blup	72	0.04	1.5e-05	-5.7	5.5	3.5e-08	-0.43	0.02	0.98	FALSE
26	GTEx	Colon Sigmoid	AF131215.2	0.10	0.00	enet	7	0.02	5.0e-02	-4.9	-5.5	4.0e-08	0.59	0.19	0.26	FALSE
44	GTEx	Nerve Tibial	NEIL2	0.34	0.20	lasso	6	0.25	8.1e-18	-5.5	-5.5	4.0e-08	0.35	0.03	0.97	FALSE
38	GTEx	Heart Left Ventricle	AF131215.2	0.05	0.01	enet	11	0.01	1.5e-01	-4.5	-5.5	4.4e-08	0.62	0.36	0.22	FALSE
39	GTEx	Heart Left Ventricle	AF131215.9	0.07	0.10	enet	8	0.10	9.4e-06	4.7	-5.5	4.5e-08	0.61	0.80	0.10	FALSE
53	GTEx	Stomach	AF131215.2	0.25	0.03	enet	22	0.14	5.2e-07	3.4	-5.4	5.1e-08	0.50	0.93	0.04	FALSE
47	GTEx	Pancreas	AF131215.2	0.16	0.16	enet	17	0.15	9.1e-07	4.7	-5.4	5.2e-08	0.62	0.99	0.00	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	NEIL2	0.08	0.08	enet	6	0.08	1.7e-09	-5.5	-5.4	5.7e-08	0.29	0.08	0.92	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	FAM167A	0.12	0.03	bslmm	620	0.08	1.3e-10	-3.4	5.4	5.8e-08	-0.52	0.26	0.74	FALSE
41	GTEx	Muscle Skeletal	MFHAS1	0.07	0.04	lasso	4	0.04	1.4e-04	-4.3	-5.4	6.5e-08	0.49	0.44	0.52	FALSE
50	GTEx	Skin Sun Exposed Lower leg	AF131215.9	0.19	0.17	enet	29	0.21	3.9e-17	4.7	-5.4	6.9e-08	0.64	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM90A25P	0.11	0.08	lasso	3	0.08	1.4e-09	-5.3	-5.4	7.3e-08	0.46	0.01	0.99	FALSE
36	GTEx	Heart Atrial Appendage	AF131215.2	0.39	0.13	enet	26	0.21	6.6e-10	4.7	-5.4	7.4e-08	0.57	0.99	0.00	FALSE
18	GTEx	Artery Tibial	AF131215.9	0.08	0.01	lasso	10	0.02	1.8e-02	3.3	-5.4	7.8e-08	0.60	0.10	0.84	FALSE
35	GTEx	Heart Atrial Appendage	NEIL2	0.19	0.20	lasso	4	0.24	4.0e-11	-5.4	-5.4	8.3e-08	0.34	0.22	0.78	FALSE
20	GTEx	Brain Cerebellar Hemisphere	AF131215.2	0.15	0.17	lasso	3	0.09	3.0e-03	4.7	-5.4	8.6e-08	0.56	0.26	0.14	FALSE
11	GTEx	Artery Aorta	NEIL2	0.30	0.14	lasso	7	0.19	1.7e-10	-5.5	-5.3	9.9e-08	0.32	0.01	0.99	FALSE
19	GTEx	Brain Cerebellar Hemisphere	FAM86B3P	0.28	0.27	lasso	8	0.28	5.4e-08	-5.2	5.3	1.0e-07	-0.51	0.78	0.14	FALSE
30	GTEx	Esophagus Mucosa	AF131215.2	0.15	0.14	enet	15	0.18	4.3e-12	4.7	-5.3	1.0e-07	0.60	1.00	0.00	FALSE
33	GTEx	Esophagus Muscularis	AF131215.2	0.10	0.08	lasso	5	0.09	2.3e-06	4.7	-5.3	1.1e-07	0.56	0.93	0.04	FALSE
55	GTEx	Thyroid	SGK223	0.19	0.35	enet	16	0.36	1.1e-28	-4.9	5.3	1.2e-07	-0.51	0.94	0.06	FALSE
51	GTEx	Small Intestine Terminal Ileum	AF131215.9	0.14	0.11	enet	16	0.06	1.6e-02	3.2	-5.3	1.3e-07	0.59	0.13	0.39	FALSE
57	GTEx	Uterus	AF131215.2	0.17	0.07	enet	13	0.09	7.1e-03	-4.8	-5.3	1.4e-07	0.68	0.15	0.46	FALSE
7	GTEx	Adrenal Gland	AF131215.2	0.20	0.16	enet	12	0.13	2.2e-05	-4.8	-5.3	1.5e-07	0.63	0.95	0.04	FALSE
12	GTEx	Artery Aorta	AF131215.2	0.09	0.09	lasso	7	0.08	2.0e-05	4.3	-5.2	1.6e-07	0.66	0.68	0.27	FALSE
17	GTEx	Artery Tibial	AF131215.2	0.07	0.03	enet	24	0.05	1.8e-04	4.7	-5.2	1.7e-07	0.61	0.07	0.92	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	FAM66A	0.23	0.26	enet	29	0.30	4.7e-39	-5.3	-5.2	2.0e-07	0.48	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	FDFT1	0.02	0.00	blup	110	0.01	1.1e-02	2.9	5.2	2.0e-07	-0.41	0.02	0.79	FALSE
13	GTEx	Artery Aorta	AF131215.9	0.13	0.05	lasso	6	0.07	1.3e-04	-4.7	-5.2	2.1e-07	0.63	0.93	0.02	FALSE
22	GTEx	Breast Mammary Tissue	AF131215.2	0.16	0.15	lasso	6	0.12	1.1e-06	4.3	-5.2	2.1e-07	0.67	0.88	0.07	FALSE
21	GTEx	Brain Cortex	FAM86B3P	0.14	0.05	enet	9	0.07	5.1e-03	-4.6	5.2	2.2e-07	-0.50	0.21	0.07	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ERI1	0.05	0.01	blup	72	0.01	5.0e-02	-5.5	5.2	2.3e-07	-0.37	0.01	0.83	FALSE
6	GTEx	Adipose Visceral Omentum	AF131215.2	0.12	0.08	lasso	6	0.06	4.6e-04	-4.5	-5.1	2.6e-07	0.62	0.60	0.32	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.2	0.16	0.11	enet	21	0.20	3.9e-11	4.7	-5.2	2.6e-07	0.62	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM167A	0.29	0.24	lasso	2	0.27	3.5e-11	-5.0	-5.1	2.7e-07	0.45	0.01	0.99	FALSE