TWAS hub - GPR109A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Liver Hepatocellular Carcinoma	0.0950	0.0530	0.0020	-0.001	0.029	0.005	NA	-0.002	0.380	0.016	0.170	NA	0.390
2	TCGA	Prostate Adenocarcinoma	0.0252	0.0138	0.0025	0.013	0.013	0.012	NA	0.010	0.014	0.013	0.018	NA	0.028

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Waist Hip Ratio (WHR)	11.8	52.8	66.3	6.3	8.1
Mouth/teeth dental problems: Mouth ulcers	10.1	16.0	17.3	4.2	3.8
Illness, injury, bereavement, stress in last 2 years	9.4	11.5	15.7	2.7	4.0
Supplements: Calcium	9.3	10.3	12.6	3.5	2.8
Serious illness, injury or assault of a close relative in last 2 years	8.1	9.3	10.4	-2.9	-3.2
Average weekly fortified wine intake	5.9	6.9	7.6	-2.8	-2.5
Hip circumference	5.9	25.5	35.6	-3.9	-6.0
Commuting to job workplace: Cycle	5.9	7.1	7.8	2.8	2.5
Qualifications: NVQ or HND or HNC or equivalent	5.7	6.9	7.1	-2.7	-2.6
Commuting to job workplace: Walk	5.5	5.9	7.2	-2.2	-2.7
Pain all over the body in last month	5.4	5.8	7.5	2.7	2.0
Risk taking	5.3	7.7	10.5	-2.2	-3.2
Falls in the last year	4.6	6.3	6.4	-2.5	-2.5
BMI	4.5	26.2	37.7	-3.8	-6.1
Number of self-reported non-cancer illnesses	4.5	7.8	12.6	-1.7	-3.5
Taking other prescription medications	4.4	6.8	10.0	-1.9	-3.2
Blood Platelet Count	4.2	49.2	69.6	8.3	5.4
Financial difficulties in last 2 years	4.2	5.7	7.2	-2.0	-2.7
Mean Putamen Volume	4.1	4.7	6.6	-1.7	-2.6
Mouth/teeth dental problems	4.0	6.1	6.6	-2.4	-2.6
Weight	4.0	19.7	27.3	-3.5	-5.2
Arm fat mass (right)	3.9	16.1	23.9	-2.9	-4.9
Worry too long after embarrassment	3.7	6.3	6.9	-2.6	-2.4
Leg fat mass (right)	3.6	14.1	21.7	-2.5	-4.7
Arm fat mass (left)	3.6	14.8	22.1	-2.7	-4.7
Primary Biliary Cirrhosis	3.5	5.0	5.3	-2.2	-2.3
Average weekly spirits intake	3.5	4.3	5.9	-1.6	-2.4
Whole body fat mass	3.5	14.6	22.8	-2.5	-4.8
Bipolar Disorder (2018)	3.4	5.4	5.9	-2.4	-2.2
Severe depression (siblings)	3.4	3.8	3.9	-1.9	-2.0
Leg fat-free mass (left)	3.4	18.1	21.7	-3.8	-4.7
Arm fat-free mass (left)	3.4	17.3	19.5	-3.9	-4.4
LDL Cholesterol	3.3	5.2	5.4	-2.3	-2.2
Supplements: Zinc	3.3	3.6	4.9	2.2	1.5
Maternal smoking around birth	3.3	4.7	6.7	2.6	1.7
Basal metabolic rate	3.3	18.4	21.8	-3.9	-4.7
Leg predicted mass (left)	3.2	17.2	20.8	-3.7	-4.6
Trunk fat mass	3.2	13.8	21.6	-2.4	-4.6
Leg fat mass (left)	3.2	12.3	19.2	-2.3	-4.4
Sensitivity / hurt feelings	3.1	5.2	5.9	-2.4	-2.1
Sitting height	3.1	21.9	25.9	-5.1	-4.2
Body mass index (BMI)	3.1	13.3	20.3	-2.5	-4.5
Arm predicted mass (left)	3.1	15.8	18.6	-3.6	-4.3
Whole body fat-free mass	3.0	16.9	18.8	-3.9	-4.3
Leg fat-free mass (right)	3.0	16.2	19.1	-3.6	-4.4
Leg predicted mass (right)	3.0	16.0	19.0	-3.6	-4.4
Ever taken oral contraceptive pill	3.0	3.3	3.5	-1.9	-1.8
Father’s age at death	2.9	3.8	7.4	-2.7	-0.5
Wheeze or whistling in the chest in last year	2.9	5.2	7.0	-1.9	-2.6
Whole body water mass	2.9	16.7	18.6	-3.8	-4.3
Fasting Glucose	2.8	3.4	4.9	1.4	2.2
Arm fat-free mass (right)	2.8	14.2	15.9	-3.5	-4.0
Trunk predicted mass	2.6	14.7	15.2	-3.8	-3.9
Average weekly red wine intake	2.6	3.8	4.0	-2.0	-1.9
Medication for hormone replacement therapy	2.5	2.8	5.0	-0.8	-2.2
Trunk fat-free mass	2.5	14.1	14.7	-3.7	-3.8
Medication: Omeprazole	2.5	3.0	3.5	-1.6	-1.9
Arm predicted mass (right)	2.5	12.7	14.4	-3.3	-3.8
Long-standing illness, disability or infirmity	2.5	3.8	6.5	-1.1	-2.5
Medication: Lisinopril	2.5	3.2	4.3	2.1	1.4
Neuroticism	2.4	5.9	6.7	-2.3	-2.6
Miserableness	2.4	4.2	6.5	-1.4	-2.6
Alcohol usually taken with meals	2.3	3.6	4.8	-2.2	-1.6
Neuroticism score	2.3	4.7	6.4	-1.7	-2.5
Arm fat percentage (right)	2.3	9.2	15.8	-1.6	-4.0
Suffer from ‘nerves’	2.3	3.6	3.7	-1.9	-1.9
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	3.0	-1.6	-1.7
Trunk fat percentage	2.2	8.9	15.3	-1.6	-3.9
Had menopause	2.2	2.7	3.6	-1.9	-1.4
Arm fat percentage (left)	2.2	8.7	15.0	-1.5	-3.9
Impedance of leg (left)	2.1	10.2	10.7	3.3	3.1
Body fat percentage	2.1	8.2	14.4	-1.4	-3.8
Ever had prostate specific antigen (PSA) test	2.1	2.4	3.4	-1.8	-1.2
Qualifications: None of the above	2.0	4.3	5.6	2.4	1.7
Allergy	2.0	4.7	6.1	1.8	2.5
Medication: Seretide 50 evohaler	2.0	2.3	3.7	-1.0	-1.9
Bipolar Disorder (2011)	1.9	1.8	2.9	-0.9	-1.7
Leg fat percentage (right)	1.9	6.9	12.4	-1.2	-3.5
HbA1C	1.8	2.0	2.3	-1.5	-1.3
Respiratory disease	1.8	4.1	6.2	-1.4	-2.5
Medication: Co-codamol	1.8	2.1	3.8	-0.6	-1.9
Impedance of leg (right)	1.8	8.5	8.8	3.0	2.9
Asthma	1.8	3.5	5.3	-1.3	-2.3
Heart disease (mother)	1.8	2.2	3.4	-1.0	-1.8
Had major operations	1.8	2.1	3.9	-0.6	-2.0
Schizophrenia vs Biploar Disorder	1.7	2.2	3.8	0.8	2.0
Neuroticism (2016)	1.7	2.4	3.0	-1.7	-1.3
Exposure to tobacco smoke at home	1.7	1.9	3.1	1.8	0.9
Townsend deprivation index at recruitment	1.6	2.3	2.4	1.5	1.6
Hayfever, allergic rhinitis or eczema	1.6	3.5	4.0	-1.7	-2.0
Ever had bowel cancer screening	1.6	1.9	3.1	-0.8	-1.8
Leg fat percentage (left)	1.6	5.7	10.5	-1.0	-3.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.7	1.6	0.7
Diabetes (mother)	1.5	2.0	3.7	-1.9	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	4.3	-0.9	-2.1
Impedance of whole body	1.5	7.6	8.4	2.9	2.6
Hair/balding pattern: Pattern 2	1.4	1.8	2.1	1.4	1.2
Chronic bronchitis/emphysema (mother)	1.4	1.7	2.6	-0.9	-1.6
Verbal and Numeric Reasoning (VNR)	1.3	3.2	4.0	2.0	1.6
Tanning	1.3	15.9	16.1	-4.0	-4.0
Medication: Lansoprazole	1.3	1.5	1.6	1.2	1.2
Asthma (self-reported)	1.3	2.5	4.4	-0.8	-2.1
Ever smoked	1.3	2.2	3.0	-1.7	-1.2
Bipolar Disorder or Schizophrenia	1.2	3.0	3.9	-1.5	-2.0
Chronotype (morning person)	1.2	2.7	3.8	-2.0	-1.2
Nervous feelings	1.2	2.2	2.7	-1.6	-1.3
Forced vital capacity (FVC)	1.2	4.5	4.8	-2.2	-2.1
Mouth/teeth dental problems: Dentures	1.2	2.0	2.4	1.2	1.6
Overall health rating	1.2	2.5	4.4	-0.8	-2.1
Illnesses of father: None of the above (group 1)	1.2	1.5	2.8	0.4	1.7
Ever depressed for a whole week	1.2	1.5	2.1	-1.5	-0.9
Unable to work because of sickness or disability	1.2	1.6	1.8	1.2	1.3
Allergy or Eczema	1.1	2.9	3.7	-1.9	-1.4
Cardiovascular Disease	1.1	3.7	4.8	-1.6	-2.2
Ever had hysterectomy (womb removed)	1.1	1.3	2.1	-1.5	-0.7
Serious illness, injury or assault to yourself	1.1	1.4	1.4	-1.2	-1.2
Pulse rate	1.1	1.9	2.9	-1.0	-1.7
Depression (self-reported)	1.1	1.3	2.4	-0.4	-1.6
Illnesses of mother	1.1	1.3	2.2	0.7	1.5
Breast cancer (self-reported)	1.1	1.3	1.8	-1.4	-0.9
Medication: Aspirin	1.1	1.5	1.7	1.1	1.3
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.2	-0.8	-1.5
Alcohol drinker status: Never	1.1	1.4	2.7	1.6	0.3
Worry (Nagel 2018)	1.0	2.2	3.4	-1.8	-1.0
HDL Cholesterol	1.0	1.6	3.1	0.4	-1.8
Lung FEV1/FVC ratio	1.0	5.2	6.0	2.1	2.5
Worrier / anxious feelings	1.0	1.9	2.0	-1.4	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	2.2	-0.9	-1.5
Birth weight	1.0	2.2	2.8	-1.3	-1.7
Exposure to tobacco smoke outside home	1.0	1.3	2.3	0.5	1.5
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.3	-1.2	-1.0
Alzheimer’s Disease (in mother)	0.9	1.0	1.6	0.7	1.3
Reaction Time	0.9	1.7	2.0	-1.2	-1.4
Rheumatoid Arthritis	0.9	1.3	2.0	1.4	0.8
Blood Red Count	0.9	8.4	10.8	-2.4	-3.3
Fed-up feelings	0.9	1.6	3.0	-0.5	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	2.4	-0.3	-1.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.5	-1.2	-0.8
Breastfed as a baby	0.9	1.1	2.2	-1.5	0.1
Tense / ‘highly strung’	0.9	1.5	2.1	-0.9	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.2	0.2	-1.5
Mean time to correctly identify matches	0.9	1.8	2.6	-1.0	-1.6
Medication: Aspirin	0.9	1.2	1.3	1.0	1.1
Knee pain experienced in last month	0.9	1.4	1.6	-1.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.1	-0.1	-1.4
Number of treatments/medications taken	0.8	1.5	3.0	0.0	-1.7
Qualifications: CSEs or equivalent	0.8	1.1	1.2	1.1	1.0
High blood pressure	0.8	2.3	3.9	-0.8	-2.0
Impedance of arm (right)	0.8	3.9	5.1	2.3	1.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	3.6	-1.9	-1.3
Medication: Cholesterol lowering	0.8	1.3	2.4	-0.5	-1.5
Number of children fathered	0.8	0.9	1.6	-1.2	-0.4
Pulse wave peak to peak time	0.8	1.0	1.2	-1.1	-0.8
Hypertension (Self-reported)	0.8	2.2	3.7	-0.9	-1.9
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.0	1.0	1.0
Average weekly champagne plus white wine intake	0.8	1.1	1.9	-1.4	-0.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	1.2	-0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.2	-0.6	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.8	1.7	-0.4
Number of incorrect matches in round	0.7	1.2	1.9	-1.4	-0.7
Impedance of arm (left)	0.7	3.1	3.6	1.9	1.6
Length of working week for main job	0.7	0.7	0.9	0.9	0.8
Gout (self-reported)	0.7	1.0	1.2	0.9	1.1
Number of full brothers	0.7	0.9	1.7	0.3	1.3
Qualifications: College or University degree	0.7	2.1	2.5	-1.6	-1.3
Alcohol intake frequency.	0.7	1.7	2.1	1.5	1.1
Comparative height size at age 10	0.7	4.0	4.4	-2.1	-1.9
Wears glasses or contact lenses	0.7	0.8	0.9	-0.8	-0.9
Hearing aid user	0.7	0.8	1.6	0.2	1.3
Heart disease (siblings)	0.7	0.8	1.4	1.2	0.4
Lupus	0.6	0.9	1.7	-0.4	-1.3
Heel T-Score	0.6	4.7	9.4	3.1	0.2
Supplements: Glucosamine	0.6	0.8	1.3	0.5	-1.1
Pulse wave reflection index	0.6	0.8	1.3	0.5	1.1
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.0	0.7	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.8	0.2	1.3
High blood pressure (siblings)	0.6	0.9	1.7	-0.3	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.3	-1.1	-0.3
High cholesterol (Self-reported)	0.6	1.1	2.1	-0.1	-1.4
Diastolic blood pressure, automated reading	0.6	1.8	2.8	0.9	-1.7
Alzheimer’s Disease (including proxy)	0.5	0.7	1.2	0.4	1.1
Height	0.5	9.7	11.0	-2.9	-3.3
Multivitamins +/- minerals	0.5	0.6	0.8	0.9	0.6
Medication: Levothyroxine sodium	0.5	0.9	1.5	-0.5	-1.2
Standing height	0.5	4.6	5.4	-2.3	-1.9
Headache pain in last month	0.5	0.9	1.5	0.4	1.2
Forced vital capacity (FVC), Best measure	0.5	1.8	1.9	-1.3	-1.4
Emphysema/chronic bronchitis	0.5	0.5	1.0	-1.0	-0.4
Chest pain or discomfort	0.5	0.7	0.8	-0.8	-0.9
Family relationship satisfaction	0.5	0.6	1.1	1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.8	-0.9	-0.5
Eye problems/disorders: Cataract	0.5	0.6	0.8	-0.6	-0.9
Back pain experienced in last month	0.5	0.8	1.1	-1.0	-0.7
Financial situation satisfaction	0.5	0.7	0.9	1.0	0.6
Medication: Bendroflumethiazide	0.5	0.8	1.2	1.1	0.6
Medication: Atorvastatin	0.5	0.6	1.1	-0.4	-1.1
Number of operations (self-reported)	0.5	0.7	1.3	0.3	-1.2
Cholesterol lowering medication	0.5	0.7	1.2	1.1	0.5
Basal cell carcinoma (self-reported)	0.5	0.6	0.9	-1.0	0.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.4	1.2	1.0
Age at First Birth	0.4	0.6	0.7	0.9	0.7
Coronary Artery Disease (CAD)	0.4	0.5	1.0	1.0	-0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	0.1	-1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.9	0.4
Chronic bronchitis/emphysema (father)	0.4	0.4	0.6	0.5	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	1.1	0.1	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.3	0.7	-1.1
Illnesses of siblings	0.4	0.6	1.1	-0.1	1.1
Hair/balding pattern: Pattern 3	0.4	0.6	0.7	-0.8	-0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	-0.6	-0.9
Medication: Amlodipine	0.4	0.5	0.7	0.5	-0.8
Eye problems/disorders: None of the above	0.4	0.5	0.9	0.3	0.9
Medication: Allopurinol	0.4	0.5	0.8	0.4	0.9
Number of full sisters	0.4	0.5	1.0	-0.1	-1.0
Guilty feelings	0.4	0.6	1.1	-0.4	-1.1
Medication: Paracetamol	0.4	0.6	0.6	0.8	0.7
Age started oral contraceptive pill	0.4	0.5	0.9	0.0	1.0
Neuroticism (Nagel 2018)	0.3	0.8	1.2	-0.7	-1.1
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.8	0.0
Crohns Disease (2017)	0.3	0.6	1.1	-1.1	-0.2
Schizophrenia (2014)	0.3	0.6	1.0	-0.4	-1.0
Triglycerides	0.3	0.5	0.9	-1.0	-0.1
Ulcerative Colitis	0.3	0.4	0.8	0.2	0.9
Blood Eosinophil Count	0.3	2.2	3.9	2.0	0.7
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.9	-0.3	-0.9
Hearing difficulty/problems: Yes	0.3	0.4	0.8	0.2	0.9
Current tobacco smoking	0.3	0.5	0.8	0.9	-0.4
Age when periods started (menarche)	0.3	0.7	1.0	0.6	1.0
Waist circumference	0.3	1.3	2.4	-0.3	-1.6
Past tobacco smoking	0.3	0.5	0.8	0.9	0.5
Hearing difficulty/problems with background noise	0.3	0.5	0.6	-0.6	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.5	0.5	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.2	-1.1	-0.7
Pulse wave Arterial Stiffness index	0.3	0.4	0.5	0.7	0.5
Loud music exposure frequency	0.3	0.3	0.5	0.4	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	0.8	-0.4
Comparative body size at age 10	0.3	0.8	1.4	0.5	1.2
Shortness of breath walking on level ground	0.3	0.4	0.5	0.7	0.5
Neck or shoulder pain in last month	0.3	0.4	0.4	-0.7	-0.6
Medication: Ibuprofen	0.3	0.4	0.6	0.8	0.3
Pulse rate, automated reading	0.3	1.0	1.5	0.7	-1.2
Age at last live birth	0.3	0.4	0.6	0.4	0.8
Supplements: Vitamin C	0.3	0.3	0.3	0.6	-0.6
Osteoporosis (self-reported)	0.3	0.4	0.4	-0.6	-0.6
Smoking status: Current	0.3	0.4	0.8	0.9	-0.3
Commuting to job workplace: Public transport	0.3	0.4	0.6	0.3	0.8
Eye problems/disorders: Glaucoma	0.3	0.4	0.5	0.6	0.7
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.4	0.2	1.2
Alcohol drinker status: Previous	0.3	0.4	0.6	-0.8	0.3
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	0.3	-0.8
Irritable Bowel Disease (IBD)	0.2	0.4	0.9	-0.9	0.2
Major Depression (MDD)	0.2	0.3	0.6	0.2	0.8
Crohns Disease (2012)	0.2	0.3	0.5	-0.7	-0.2
Blood White Count	0.2	1.7	2.0	-1.1	-1.4
Systolic Blood Pressure	0.2	0.9	1.0	0.9	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.8	0.3
Hair Pigment	0.2	4.6	4.8	2.1	2.2
Hand grip strength (right)	0.2	0.6	1.1	-0.4	-1.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.6	-0.3
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.1	-0.6
Had other major operations	0.2	0.2	0.2	0.4	0.5
Diabetes (self-reported)	0.2	0.3	0.6	0.1	-0.8
Medication: Simvastatin	0.2	0.3	0.5	-0.3	-0.7
Time employed in main current job	0.2	0.2	0.4	-0.2	-0.7
Noisy workplace	0.2	0.2	0.4	0.6	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	-0.3	1.0
Prospective memory result	0.2	0.2	0.3	-0.4	-0.5
Hair/balding pattern: Pattern 4	0.2	0.5	0.7	0.4	0.9
Peak expiratory flow (PEF)	0.2	0.4	0.9	-0.9	0.0
Age at first live birth	0.2	0.3	0.4	-0.5	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	0.3	0.6
Medication: Blood pressure	0.2	0.4	0.5	0.7	-0.6
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.2	-0.7
Friendships satisfaction	0.2	0.2	0.2	0.4	-0.5
Medication for cholesterol	0.2	0.2	0.4	-0.6	0.3
Mineral and other dietary supplements	0.2	0.3	0.5	-0.7	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.6	0.5	0.8
Depression (Nagel 2018)	0.1	0.2	0.4	-0.0	-0.7
Schizophrenia (2018)	0.1	0.3	0.5	0.1	-0.7
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.5	0.3
Ovarian Cancer	0.1	0.1	0.1	0.4	-0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	0.3	-0.4
Hand grip strength (left)	0.1	0.2	0.3	-0.4	-0.6
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.3	-0.7
Vitamin and mineral supplements	0.1	0.1	0.2	-0.4	0.1
Pack years adult smoking proportion	0.1	0.1	0.2	0.4	-0.1
Relative age voice broke	0.1	0.2	0.3	-0.5	0.3
Medication: Atenolol	0.1	0.1	0.1	-0.4	0.1
High blood pressure (mother)	0.1	0.2	0.3	0.1	-0.6
Heart attack	0.1	0.1	0.2	-0.0	0.5
Medication: Ramipril	0.1	0.2	0.3	0.2	-0.5
Alcohol intake versus 10 years previously	0.1	0.1	0.1	0.3	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.5	0.0
Lung cancer (father)	0.1	0.1	0.2	0.2	0.5
Birth weight of first child	0.1	0.1	0.1	0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	-0.6	0.2
Blood clot in the leg (DVT)	0.1	0.2	0.2	0.3	-0.5
Medication: Paracetamol	0.1	0.2	0.2	0.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.2	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.6	-0.1
Angina (self-reported)	0.1	0.1	0.2	-0.4	0.1
Migraine (self-reported)	0.1	0.1	0.1	-0.4	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.2	0.4	0.5
Mood swings	0.1	0.2	0.3	0.5	-0.3
Qualifications: nursing, teaching	0.1	0.2	0.2	0.4	0.5
Osteoarthritis (self-reported)	0.1	0.2	0.4	0.6	0.1
Medication: Gliclazide	0.1	0.1	0.2	0.0	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.3	-0.2
Average weekly beer plus cider intake	0.1	0.2	0.4	0.0	0.6
Irritability	0.1	0.1	0.2	0.4	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.1	-0.2	0.4
Myopia	0.1	0.1	0.2	0.5	0.0
Pain experienced in last month	0.1	0.2	0.5	-0.0	0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.1	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.3	-0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Smoking Status	0.0	0.0	0.0	0.2	0.0
Hypothyroidism (self reported)	0.0	0.1	0.2	0.2	-0.4
Lung FVC	0.0	0.1	0.1	0.4	0.1
Relative age of first facial hair	0.0	0.0	0.1	-0.1	0.3
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	-0.0	0.3
Angina	0.0	0.1	0.1	-0.3	0.2
Medication: Metformin	0.0	0.0	0.1	0.3	-0.2
Diabetes (father)	0.0	0.1	0.1	-0.0	-0.3
Fluid intelligence score	0.0	0.1	0.1	-0.4	-0.1
Number of live births	0.0	0.0	0.0	0.0	0.1
Happiness	0.0	0.1	0.1	0.3	-0.2
Glaucoma (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	0.3	-0.2
Health satisfaction	0.0	0.0	0.1	0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	0.1	-0.2
Leg pain on walking	0.0	0.0	0.1	-0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.1	0.3
Illnesses of father: Heart disease	0.0	0.0	0.0	-0.2	-0.2
Smoking status: Previous	0.0	0.1	0.1	-0.2	0.3
Loneliness, isolation	0.0	0.0	0.0	0.2	-0.2
Mother’s age at death	0.0	0.0	0.1	-0.1	-0.3
Medication: Blood pressure	0.0	0.0	0.0	-0.0	0.2
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.0	-0.3
Pack years of smoking	0.0	0.0	0.1	0.1	-0.2

Hub : Genes

GPR109A

Models

Trait associations