TWAS hub - GOSR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1370	0.0330	1.7e-10	0.055	0.106	0.100	0.101	0.092	2.8e-07	8.5e-13	3.4e-12	2.6e-12	2.5e-11
2	GTEx	Breast Mammary Tissue (Female)	0.0707	0.0678	1.7e-01	0.008	NA	-0.005	NA	-0.009	1.8e-01	NA	4.7e-01	NA	8.1e-01
3	GTEx	Cells Transformed fibroblasts	0.1390	0.0480	8.7e-07	0.097	NA	0.082	NA	0.022	9.4e-08	NA	9.9e-07	NA	8.4e-03
4	GTEx	Skin Sun Exposed Lower leg	0.0380	0.0200	9.2e-03	0.027	NA	0.010	NA	0.011	2.4e-03	NA	4.6e-02	NA	4.0e-02
5	GTEx	Testis	0.1150	0.0500	2.8e-03	-0.003	NA	0.001	NA	-0.005	4.4e-01	NA	2.8e-01	NA	6.6e-01
6	TCGA	Breast Invasive Carcinoma	0.0107	0.0065	7.1e-03	0.006	0.008	0.003	NA	0.005	1.4e-02	7.4e-03	8.6e-02	NA	2.4e-02
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.0550	0.0310	2.7e-03	0.028	0.030	0.004	NA	0.015	5.0e-03	3.7e-03	1.7e-01	NA	3.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6	7
Systolic Blood Pressure	19.9	99.6	151.3	8.2	9.6	11.8	10.3	12.3	11.9
Systolic blood pressure, automated reading	13.9	40.3	62.4	6.8	5.8	7.4	6.4	7.9	6.6
Cardiovascular Disease	9.1	29.9	48.3	2.8	5.7	6.7	5.7	7.0	6.6
Blood Red Count	7.2	69.3	127.7	-3.2	9.3	10.2	9.9	11.3	7.7
Hearing aid user	5.7	6.4	11.5	0.5	2.9	3.0	3.4	3.1	2.4
HDL Cholesterol	5.5	9.2	14.6	1.4	3.3	3.8	3.4	3.8	3.3
Medication: Blood pressure	5.4	9.5	17.3	1.1	3.8	3.7	3.3	4.2	3.0
Average weekly red wine intake	5.0	7.3	11.6	-1.6	-2.7	-3.4	-3.1	-3.2	-3.2
Coronary Artery Disease (CAD)	4.9	5.8	11.6	1.5	1.8	2.9	2.5	3.0	3.4
Hypertension (Self-reported)	4.7	13.0	23.6	2.3	3.7	4.3	3.6	4.9	4.1
Medication for cholesterol, blood pressure or diabetes	4.6	7.6	12.7	-1.2	-3.5	-3.2	-2.9	-3.6	-2.9
Pulse rate, automated reading	4.3	13.9	34.3	-3.0	-2.8	-4.3	-3.6	-3.8	-5.9
High blood pressure	4.2	11.6	21.0	2.5	3.4	4.0	3.2	4.6	4.0
Vascular/heart problems diagnosed by doctor	3.9	10.5	20.4	-2.2	-3.2	-3.8	-2.9	-4.5	-4.0
Chronotype (morning person)	3.7	8.5	13.9	-0.7	3.4	3.6	3.4	3.7	3.0
Medication: Amlodipine	3.6	5.0	8.9	0.7	2.6	2.8	2.4	3.0	2.2
Ever had prostate specific antigen (PSA) test	3.6	4.1	7.1	-0.3	-1.9	-2.7	-2.7	-2.5	-2.1
Major Depression (MDD)	3.3	4.0	8.9	0.8	2.1	2.5	2.1	3.0	1.8
Stomach or abdominal pain in last month	3.2	4.0	8.9	-0.8	2.8	2.3	3.0	1.8	1.4
Sitting height	3.2	22.6	36.7	0.6	-4.3	-6.1	-5.7	-6.0	-5.8
Medication: Bendroflumethiazide	3.2	4.8	10.8	3.3	1.4	2.1	1.2	2.5	2.9
Asthma	3.1	6.1	11.7	1.1	2.2	3.0	2.7	2.8	3.4
Hair/balding pattern: Pattern 4	3.1	7.6	49.4	7.0	-1.1	-0.2	-1.0	-0.5	1.1
Hand grip strength (right)	3.0	8.2	13.8	-0.6	-2.9	-3.5	-3.6	-3.7	-3.1
Lung cancer (father)	2.9	3.4	6.7	-0.4	-2.4	-2.2	-1.9	-1.8	-2.6
Overall health rating	2.9	6.3	14.2	-0.2	3.1	3.0	3.8	3.1	1.1
Qualifications: CSEs or equivalent	2.8	3.7	5.8	-1.8	2.1	2.1	1.9	2.4	2.1
Eye problems/disorders: None of the above	2.8	3.3	5.8	2.3	1.6	2.0	1.3	1.9	2.4
Mouth/teeth dental problems: Mouth ulcers	2.7	4.4	8.0	-0.5	1.9	2.5	2.4	2.6	2.8
Wears glasses or contact lenses	2.7	3.1	7.7	-1.8	-1.1	-1.9	-1.6	-1.8	-2.8
Illnesses of father: Heart disease	2.6	3.5	6.5	1.7	1.1	2.4	1.7	2.4	2.5
Type 2 Diabetes (T2D) (2012)	2.5	2.9	6.9	2.6	1.5	1.9	1.4	1.9	1.5
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	7.4	-1.9	2.2	2.1	2.4	2.7	0.9
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	9.4	-0.0	-2.6	-2.3	-3.1	-2.4	-0.9
Schizophrenia vs Biploar Disorder	2.4	3.2	6.6	-0.6	-2.0	-2.4	-2.0	-2.6	-1.4
Fed-up feelings	2.4	4.3	6.8	-0.6	2.3	2.6	2.4	2.6	2.4
Number of treatments/medications taken	2.3	4.1	8.0	1.0	2.1	2.5	2.0	2.8	2.1
Hair/balding pattern: Pattern 3	2.3	3.4	5.7	1.7	-1.8	-2.2	-2.2	-2.4	-1.6
Impedance of arm (left)	2.3	10.4	35.1	5.9	1.6	2.5	1.5	2.6	4.5
Leg pain on walking	2.3	2.9	5.5	0.0	1.5	2.3	2.3	2.1	1.8
Diastolic blood pressure, automated reading	2.2	6.7	12.8	3.6	2.3	2.9	2.6	3.2	1.8
Impedance of arm (right)	2.1	9.7	34.4	5.9	1.6	2.5	1.5	2.6	4.0
Loud music exposure frequency	2.1	2.3	4.9	0.2	-2.2	-1.7	-1.6	-2.2	-1.0
Health satisfaction	2.1	2.8	5.2	0.1	1.9	2.2	2.3	2.0	1.3
Mood swings	2.1	3.7	6.3	-1.1	2.0	2.4	2.2	2.5	2.0
Medication: Atorvastatin	2.1	2.6	4.1	1.2	1.6	2.0	2.0	2.0	1.4
Time employed in main current job	2.0	2.3	3.7	1.5	-1.7	-1.6	-1.9	-1.6	-1.4
Qualifications: A levels/AS levels or equivalent	2.0	4.4	8.9	0.6	-2.6	-2.5	-3.0	-2.1	-2.0
Asthma (self-reported)	2.0	4.0	9.2	0.9	1.6	2.4	2.1	2.3	3.0
Osteoarthritis (self-reported)	2.0	2.6	5.9	0.7	-2.4	-1.7	-2.0	-1.7	-1.3
Schizophrenia (2014)	1.9	4.1	10.7	-2.0	-1.6	-2.4	-1.0	-2.2	-3.3
Hand grip strength (left)	1.9	5.1	8.0	-0.1	-2.3	-2.7	-2.7	-2.8	-2.8
Medication: Paracetamol	1.9	3.1	5.2	-0.7	2.0	2.3	2.1	2.1	1.9
Mean time to correctly identify matches	1.9	3.7	6.4	-2.1	-2.0	-2.2	-1.7	-2.5	-1.7
Eye problems/disorders: Glaucoma	1.9	2.3	5.3	-2.3	-1.5	-1.6	-1.7	-1.4	-1.0
High cholesterol (Self-reported)	1.9	3.4	5.2	1.2	2.3	2.2	2.1	2.2	1.8
Impedance of whole body	1.9	9.9	34.2	5.9	1.4	2.5	1.5	2.6	4.2
Frequency of depressed mood in last 2 weeks	1.8	2.5	4.0	-2.0	2.0	1.6	1.5	1.7	1.5
Relative age voice broke	1.8	2.7	10.6	-3.3	1.2	1.3	1.6	1.1	1.2
Medication: Blood pressure	1.8	3.4	5.8	2.1	1.5	2.0	1.7	2.4	2.1
Blood Platelet Count	1.7	19.3	33.9	1.4	5.0	5.7	5.0	5.8	4.1
Trunk fat-free mass	1.7	9.9	20.6	-3.4	-2.0	-3.5	-2.9	-3.5	-4.5
Pulse rate	1.7	2.9	6.4	-0.9	-1.6	-1.9	-2.0	-1.7	-2.5
Trunk predicted mass	1.7	9.9	20.5	-3.4	-2.0	-3.5	-2.9	-3.5	-4.5
Length of working week for main job	1.7	1.9	3.4	-1.3	-0.9	-1.8	-1.9	-1.8	-1.1
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.0	2.0	-1.8	-1.4	-1.7	-1.0	-1.2
Illnesses of father: High blood pressure	1.7	2.1	3.6	0.2	1.5	1.8	1.9	1.9	1.4
Average weekly beer plus cider intake	1.7	2.5	4.8	0.8	1.7	1.9	2.2	1.8	1.5
Crohns Disease (2012)	1.6	2.7	4.9	-0.0	-1.4	-2.2	-1.7	-2.1	-2.2
Neuroticism (2016)	1.6	2.3	4.3	-0.7	2.1	1.6	1.9	1.9	1.2
Relative age of first facial hair	1.6	3.3	19.0	-4.4	0.7	0.8	1.2	0.8	0.8
Trunk fat percentage	1.6	6.3	9.4	2.7	3.1	2.7	2.7	3.1	1.8
Serious illness, injury or assault to yourself	1.6	1.9	3.7	1.2	1.2	1.8	1.3	1.9	1.4
Alcohol usually taken with meals	1.6	2.6	5.4	0.1	-1.6	-2.0	-2.3	-1.9	-1.6
Hair/balding pattern: Pattern 2	1.6	2.0	8.2	-2.9	0.9	1.0	1.4	1.4	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	3.8	-0.1	2.0	1.9	1.7	2.0	1.8
Arm fat-free mass (right)	1.6	8.1	18.7	-3.2	-1.7	-3.1	-2.4	-3.2	-4.3
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	4.6	-0.7	-1.2	-1.8	-1.8	-2.1	-1.2
Reaction Time	1.5	2.9	5.5	-2.4	-2.1	-1.7	-1.6	-1.9	-1.1
Body Mass Index (BMI) (2010)	1.5	2.1	5.0	-2.0	-0.8	-1.5	-1.0	-1.4	-2.2
LDL Cholesterol	1.5	2.3	5.1	-0.2	1.5	2.2	2.3	1.5	1.3
Neuroticism	1.5	3.6	5.7	-2.4	1.6	2.1	2.2	2.1	1.9
Supplements: Glucosamine	1.5	2.0	4.8	-1.1	-1.0	-1.8	-1.4	-2.2	-1.3
Arm fat percentage (right)	1.5	6.1	10.5	1.4	3.2	2.9	2.9	3.2	1.8
Medication: Cholesterol lowering	1.5	2.3	3.6	0.6	1.9	1.7	1.6	1.9	1.7
Headache pain in last month	1.5	2.6	5.8	-2.4	1.4	1.7	1.7	1.8	1.0
Forced vital capacity (FVC), Best measure	1.5	5.6	15.1	3.9	-2.4	-2.2	-2.7	-2.5	-0.4
Body fat percentage	1.5	5.9	9.7	2.1	3.1	2.8	2.8	3.1	1.6
Medication for pain relief, constipation, heartburn	1.5	2.6	4.8	1.1	-1.8	-2.1	-1.8	-2.2	-1.1
Arm fat percentage (left)	1.5	6.1	10.3	1.3	3.2	2.9	2.9	3.2	1.9
Mother’s age at death	1.5	1.9	3.1	-0.1	-1.5	-1.7	-1.8	-1.6	-1.6
Depressed Affect (Nagel 2018)	1.4	2.9	4.3	-1.9	1.6	2.1	1.9	2.1	1.5
Lung FVC	1.4	7.2	23.9	4.9	-2.7	-2.3	-2.6	-2.7	-0.2
Financial difficulties in last 2 years	1.4	1.9	3.9	0.3	2.0	1.6	1.5	1.3	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	13.3	3.6	-2.2	-1.8	-2.2	-2.2	-0.3
Blood clot in the leg (DVT)	1.4	1.8	4.0	-0.4	-1.1	-1.6	-1.7	-2.0	-1.1
Arm predicted mass (right)	1.4	7.1	16.3	-3.6	-1.2	-2.8	-1.9	-2.8	-4.0
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.3	-0.6	-1.6	-1.7	-1.7	-1.8	-0.4
Whole body fat-free mass	1.4	7.7	18.3	-3.0	-1.5	-3.1	-2.4	-3.1	-4.3
Whole body water mass	1.4	7.8	18.1	-3.1	-1.5	-3.1	-2.4	-3.1	-4.2
Had menopause	1.3	1.7	3.0	-0.2	-1.5	-1.6	-1.4	-1.7	-1.4
Pulse wave reflection index	1.3	1.6	3.0	1.3	1.2	1.5	1.0	1.3	1.7
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.7	0.5	1.0	1.7	1.6	1.4	1.4
Average weekly champagne plus white wine intake	1.3	1.8	4.1	2.0	-0.7	-1.5	-1.6	-1.7	-0.5
Heart disease (siblings)	1.3	1.6	3.0	-0.8	1.5	1.4	1.4	1.7	1.1
Arm predicted mass (left)	1.3	6.5	17.0	-3.0	-1.1	-2.7	-1.9	-2.7	-4.1
Ovarian Cancer	1.2	1.6	3.9	1.3	-1.4	-1.3	-0.6	-1.2	-2.0
Nervous feelings	1.2	2.2	3.9	-2.0	1.3	1.4	1.5	1.7	1.6
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	4.3	-2.1	1.5	0.8	1.3	1.1	-0.3
Mouth/teeth dental problems	1.2	1.8	4.9	0.4	-1.2	-1.6	-2.2	-1.8	-0.7
Glaucoma (self-reported)	1.2	1.5	5.3	-2.3	-1.1	-1.1	-0.9	-1.0	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.9	-2.0	-0.5	-1.1	-0.6	-1.5	-1.2
Osteoporosis (self-reported)	1.2	1.5	2.3	-1.5	1.3	1.2	1.5	1.3	1.1
Ever taken oral contraceptive pill	1.2	1.3	2.5	-0.9	-0.6	-1.4	-1.5	-1.3	-1.6
Arm fat-free mass (left)	1.2	6.2	15.9	-3.1	-1.1	-2.6	-1.8	-2.6	-4.0
Neuroticism (Nagel 2018)	1.1	2.5	4.1	-2.0	1.3	1.8	1.5	1.9	1.6
Waist Hip Ratio (WHR)	1.1	5.0	9.0	-2.1	2.8	2.4	3.0	2.6	1.3
Forced vital capacity (FVC)	1.1	4.2	13.1	3.6	-1.9	-1.8	-2.2	-2.2	-0.2
Falls in the last year	1.1	1.4	2.9	0.0	-1.1	-1.6	-1.6	-1.7	-0.9
Happiness	1.1	1.4	3.1	1.4	1.2	1.5	1.8	0.9	0.7
Comparative body size at age 10	1.1	3.1	5.7	-2.4	2.3	1.7	2.0	1.9	0.4
Medication for cholesterol	1.1	1.7	2.7	-1.6	-0.9	-1.5	-1.2	-1.6	-1.6
Commuting to job workplace: Public transport	1.1	1.4	2.5	-1.4	-0.9	-1.6	-1.3	-1.3	-0.9
Alcohol drinker status: Previous	1.1	1.3	2.8	-0.6	-0.8	-1.6	-1.1	-1.7	-1.1
Fasting Glucose	1.0	1.2	2.1	1.5	0.8	1.4	1.2	0.9	1.3
Respiratory disease	1.0	2.2	5.7	1.3	0.9	1.8	1.2	1.6	2.4
Medication: Ramipril	1.0	1.3	3.8	-0.3	1.2	1.3	1.4	2.0	0.4
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	8.9	3.0	-1.8	-1.8	-2.0	-2.1	-0.7
Standing height	1.0	9.5	17.1	0.7	-2.6	-4.0	-3.9	-4.1	-3.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.7	0.4	1.0	1.5	1.6	1.4	0.8
High blood pressure (siblings)	1.0	1.5	3.4	1.4	1.1	1.3	1.0	1.9	1.0
Medication: Omeprazole	1.0	1.2	3.4	1.0	-1.8	-1.0	-1.3	-1.2	-0.1
Medication: Paracetamol	1.0	1.5	2.3	-1.2	1.5	1.4	1.4	1.3	1.0
Ever depressed for a whole week	1.0	1.2	2.7	-0.3	1.6	1.3	1.6	1.0	0.8
Schizophrenia (2018)	0.9	1.9	7.5	-1.7	-0.7	-1.3	-0.1	-0.9	-2.7
Primary Biliary Cirrhosis	0.9	1.3	5.8	2.4	-0.9	-0.7	-0.8	-0.9	-0.7
Hair Pigment	0.9	25.7	46.5	1.4	-6.5	-6.0	-6.1	-6.8	-4.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.1	-1.7	-0.3	-1.0	-0.3	-1.1	-1.8
Ever had hysterectomy (womb removed)	0.9	1.0	5.0	-2.2	0.2	-0.6	-0.1	-0.4	-1.2
Medication for hormone replacement therapy	0.9	1.0	2.1	-0.4	-1.1	-1.2	-0.9	-1.4	-1.2
Maternal smoking around birth	0.9	1.2	2.2	-0.8	-1.3	-1.2	-1.3	-0.9	-1.5
Medication: Atenolol	0.9	1.1	2.7	0.5	1.4	1.1	1.3	1.6	0.5
Impedance of leg (left)	0.9	4.4	16.4	4.0	0.6	1.6	0.9	1.9	2.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.8	-0.2	1.7	1.6	1.5	1.3	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.6	-1.1	1.2	1.2	1.1	1.6	0.2
Medication: Lansoprazole	0.9	1.0	2.5	-0.3	-1.6	-1.1	-1.1	-1.1	-0.8
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.4	0.9	0.6	1.3	0.8	1.4	1.6
Family relationship satisfaction	0.9	1.1	2.1	1.0	1.0	1.3	1.4	1.1	0.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.4	-0.9	1.0	1.1	1.6	1.1	0.1
Illnesses of siblings: Diabetes	0.9	1.1	2.4	0.4	1.5	1.3	1.3	1.0	0.8
Smoking status: Previous	0.9	1.3	2.3	0.3	-1.2	-1.3	-1.4	-1.5	-1.3
Basal metabolic rate	0.9	5.1	13.5	-2.6	-0.9	-2.4	-1.7	-2.4	-3.7
Alzheimer’s Disease (in father)	0.8	0.9	3.1	-0.7	-0.7	-1.1	-0.5	-1.0	-1.8
Verbal and Numeric Reasoning (VNR)	0.8	1.8	4.6	0.8	-0.9	-1.4	-0.7	-2.0	-2.1
Breast Cancer	0.8	2.0	10.8	-3.3	0.0	-0.8	-0.3	-0.6	-1.6
Blood Eosinophil Count	0.8	5.9	16.7	4.1	-3.1	-1.7	-2.4	-2.4	0.5
Sensitivity / hurt feelings	0.8	1.4	2.6	-1.6	1.2	1.2	1.3	1.2	1.1
Impedance of leg (right)	0.8	3.9	15.2	3.9	0.5	1.5	0.8	1.6	2.5
Leg fat-free mass (left)	0.8	4.1	10.7	-2.2	-0.8	-2.2	-1.6	-2.3	-3.3
Average weekly fortified wine intake	0.8	0.9	3.3	1.8	-0.7	-0.8	-1.0	-0.5	-0.9
Number of incorrect matches in round	0.8	1.3	2.7	-1.0	-1.0	-1.5	-1.6	-1.4	0.0
Neuroticism score	0.8	1.6	3.4	-1.8	0.7	1.3	1.1	1.4	1.6
Number of live births	0.8	1.1	2.2	-0.6	0.6	1.5	1.2	1.2	1.4
Prospective memory result	0.8	1.0	6.1	-2.5	0.1	-0.5	-0.1	-0.3	-0.5
Illnesses of mother	0.8	1.0	2.6	-0.2	-0.8	-1.3	-1.3	-1.6	-0.5
Leg fat-free mass (right)	0.8	4.1	10.8	-2.3	-0.7	-2.2	-1.6	-2.2	-3.3
Leg predicted mass (right)	0.8	4.2	11.1	-2.3	-0.7	-2.2	-1.6	-2.2	-3.3
Medication: Lisinopril	0.8	1.1	1.5	0.5	1.2	1.2	1.1	1.2	1.2
Basal cell carcinoma (self-reported)	0.8	0.9	1.7	-0.1	-0.9	-1.2	-1.2	-1.3	-1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	2.1	1.3	-1.0	-0.9	-0.7	-0.7	-1.4
Height	0.7	13.5	23.8	1.1	-2.2	-4.9	-4.3	-4.8	-4.9
Type 2 Diabetes (T2D) (2018)	0.7	1.4	4.5	-1.2	-0.6	-1.2	-0.6	-1.2	-2.1
Angina	0.7	0.9	3.1	0.5	0.8	1.0	0.6	1.8	1.1
Supplements: Zinc	0.7	0.8	2.1	-1.4	1.0	0.7	1.3	0.5	0.1
Leg predicted mass (left)	0.7	3.9	10.8	-2.2	-0.7	-2.1	-1.5	-2.2	-3.3
Qualifications: None of the above	0.7	1.5	2.9	1.0	0.5	1.5	1.7	1.5	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.9	0.4	1.1	1.0	1.1	1.4	-0.6
Wheeze or whistling in the chest in last year	0.7	1.3	2.5	-0.1	1.2	1.6	1.2	1.4	1.4
Qualifications: College or University degree	0.7	2.2	4.0	1.2	-1.3	-2.0	-1.8	-1.8	-1.3
Medication: Ibuprofen	0.7	0.8	1.9	-1.0	1.1	0.9	0.8	1.4	0.1
Alcohol intake frequency.	0.7	1.7	4.0	-1.1	1.3	1.4	1.5	1.0	2.0
Supplements: Vitamin C	0.7	0.8	4.0	-2.0	-0.3	-0.5	-0.7	-0.4	-0.9
Diabetes diagnosed by doctor	0.7	1.1	5.5	-0.5	-0.2	-1.1	-0.1	-0.8	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.3	1.5	-1.1	-0.5	-0.9	-0.8	0.2
Eye problems/disorders: Cataract	0.7	0.8	2.0	0.1	-1.4	-0.9	-1.2	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	9.0	3.0	-0.7	-0.5	-0.7	-0.7	0.2
Number of self-reported non-cancer illnesses	0.7	1.2	2.6	0.4	1.2	1.2	1.0	1.6	1.3
Guilty feelings	0.7	1.0	2.5	-1.6	1.2	1.0	1.2	0.9	0.5
Leg fat percentage (left)	0.7	2.4	5.3	0.5	2.1	1.8	1.9	2.3	0.2
Myopia	0.7	1.0	3.1	0.4	1.4	1.0	1.8	0.9	0.6
Bipolar Disorder or Schizophrenia	0.6	1.5	5.1	-2.1	0.0	-0.6	0.6	-0.4	-2.2
Lupus	0.6	0.9	2.1	1.4	0.7	1.1	1.0	1.0	0.7
Triglycerides	0.6	1.0	1.8	1.4	0.9	1.1	1.1	0.7	1.1
Diabetes (mother)	0.6	0.8	2.0	-0.2	1.3	1.1	1.4	0.8	0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.5	0.3	0.8	1.0	1.2	1.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	0.4	1.3	0.7	1.3	0.9	-0.3
Medication: Levothyroxine sodium	0.6	1.1	2.4	-0.2	-1.6	-1.2	-1.0	-0.9	-1.4
Trunk fat mass	0.6	2.4	5.5	1.5	2.3	1.6	1.7	1.9	0.4
Waist circumference	0.6	2.2	5.2	-1.6	2.3	1.2	1.8	1.6	-0.5
Past tobacco smoking	0.6	1.0	2.0	-0.6	1.0	1.1	1.4	1.2	1.1
Hearing difficulty/problems with background noise	0.6	0.9	4.7	-2.2	0.5	0.1	0.4	-0.1	-1.0
Noisy workplace	0.6	0.7	1.7	0.8	0.1	1.2	1.0	0.7	1.3
Peak expiratory flow (PEF)	0.6	1.3	3.1	1.8	-0.8	-1.2	-1.2	-1.4	-1.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.6	-0.0	-1.4	-1.3	-1.2	-1.0	-1.6
Leg fat percentage (right)	0.6	2.2	4.5	0.5	2.1	1.7	1.9	2.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	2.2	-1.5	-0.6	-0.9	-0.4	-1.0	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.7	0.4	0.8	1.3	1.1	1.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.5	1.9	0.1	0.5	0.1	0.6	1.0
Ever had bowel cancer screening	0.6	0.7	2.0	1.4	1.2	0.5	0.8	0.3	0.6
Smoking status: Current	0.6	1.0	2.3	1.5	0.8	1.0	0.7	1.1	1.0
Alzheimer’s Disease (in mother)	0.5	0.6	3.5	1.9	-0.6	0.0	-0.2	0.1	-0.1
BMI	0.5	2.7	5.3	-2.3	2.2	1.3	2.1	1.4	-0.8
Smoking Status	0.5	1.3	2.4	1.4	-1.0	-1.2	-1.3	-1.5	-0.8
Medication: Co-codamol	0.5	0.5	0.8	0.9	0.9	0.8	0.8	0.9	-0.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.7	1.6	0.1	0.4	-0.0	0.4	0.8
High blood pressure (mother)	0.5	0.7	1.9	1.4	0.7	0.9	0.4	0.9	0.8
Diabetes (self-reported)	0.5	0.8	4.0	-0.7	-0.1	-0.8	0.1	-0.6	-2.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	3.0	-1.7	0.4	-0.2	0.5	-0.2	-0.8
Medication: Simvastatin	0.5	0.7	1.4	0.6	0.6	1.0	0.8	1.0	1.2
Fluid intelligence score	0.5	1.0	2.2	1.4	-0.4	-0.9	-0.3	-1.5	-1.3
Alcohol intake versus 10 years previously	0.5	0.8	2.8	1.7	0.3	0.8	1.0	0.6	0.8
Pulse wave Arterial Stiffness index	0.5	0.6	3.2	1.8	0.5	0.4	-0.3	0.4	0.5
Exposure to tobacco smoke outside home	0.5	0.7	1.9	-0.8	0.7	0.8	1.0	1.4	-0.3
Commuting to job workplace: Walk	0.5	0.6	1.6	-0.1	0.7	0.8	0.8	0.8	1.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-0.3	-0.4	-1.1	-1.0	-1.0	-1.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.5	0.9	0.7	1.0	1.2	0.6	0.0
Age started oral contraceptive pill	0.5	0.6	1.7	1.3	0.8	0.6	0.8	0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.4	0.3	-1.1	-0.9	-0.9	-1.2	-0.3
Bipolar Disorder (2018)	0.4	0.6	1.5	-1.2	0.9	0.6	1.1	0.6	-0.2
Depression (Nagel 2018)	0.4	0.6	2.4	-1.6	0.7	0.6	0.6	0.7	0.6
Mean Putamen Volume	0.4	0.4	2.4	-1.6	-0.3	-0.3	-0.5	-0.3	-0.3
Blood White Count	0.4	2.7	5.1	-0.2	2.0	2.3	1.9	2.2	1.1
Severe depression (siblings)	0.4	0.4	1.2	0.0	1.1	0.7	0.4	1.0	0.2
Townsend deprivation index at recruitment	0.4	0.6	2.4	-0.0	1.5	0.7	0.9	0.7	0.3
Current tobacco smoking	0.4	0.6	1.6	1.3	0.7	0.7	0.5	0.8	0.7
Multivitamins +/- minerals	0.4	0.5	1.0	-0.0	0.9	0.7	0.6	0.7	1.0
Body mass index (BMI)	0.4	1.7	3.4	-1.2	1.8	1.2	1.6	1.5	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.1	1.5	0.6	1.1	0.9	1.3	0.8
Depression (self-reported)	0.4	0.5	0.8	-0.2	0.8	0.9	0.9	0.7	0.9
Arm fat mass (right)	0.4	1.6	4.4	-0.1	2.1	1.3	1.7	1.6	-0.1
Birth weight of first child	0.4	0.7	1.7	-0.5	-0.0	-1.1	-0.7	-1.3	-1.0
Pulse wave peak to peak time	0.4	0.4	1.9	-1.4	-0.6	-0.5	0.1	-0.5	-0.5
Angina (self-reported)	0.4	0.5	2.2	0.2	0.5	0.7	0.3	1.5	0.9
Medication: Allopurinol	0.4	0.5	0.7	0.8	0.7	0.8	0.7	0.8	0.7
Whole body fat mass	0.4	1.8	4.8	0.7	2.2	1.3	1.6	1.7	0.0
Comparative height size at age 10	0.4	2.1	4.0	0.8	-1.2	-1.9	-1.7	-2.0	-1.4
Chest pain or discomfort	0.4	0.6	1.2	1.1	0.6	0.9	0.4	0.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.9	-0.1	-0.9	-1.1	-1.2	-1.4	-1.0
Long-standing illness, disability or infirmity	0.4	0.7	1.1	-1.0	1.0	0.8	1.1	0.8	0.4
Arm fat mass (left)	0.4	1.7	4.7	-0.1	2.2	1.4	1.6	1.7	0.1
Miserableness	0.4	0.8	1.7	-1.3	1.1	0.8	0.8	1.0	0.4
Commuting to job workplace: Cycle	0.4	0.5	0.8	0.7	-0.6	-0.8	-0.9	-0.9	0.8
Intelligence (Savage-Jansen 2018)	0.3	1.1	3.6	0.6	0.4	-0.9	-0.1	-1.6	-1.9
Worry (Nagel 2018)	0.3	0.6	2.1	-1.4	-0.6	0.4	-0.1	0.6	1.2
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.6	-0.6	-0.5	-0.3	-0.7	-0.6
Hypothyroidism (self reported)	0.3	0.7	1.8	0.6	-0.9	-0.8	-0.8	-0.6	-1.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.2	-0.6	-0.2	-0.6	0.1	-0.6	-1.1
Vitamin and mineral supplements	0.3	0.4	1.2	1.1	-0.9	-0.4	-0.3	-0.5	-0.3
Pack years adult smoking proportion	0.3	0.4	1.1	0.2	0.6	0.6	0.9	1.1	-0.7
Age when periods started (menarche)	0.3	0.6	1.0	0.8	1.0	0.9	0.9	0.9	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.5	0.8	1.0	0.9	0.8	1.2	0.8
Had other major operations	0.3	0.4	1.0	0.6	0.3	0.8	0.6	0.7	1.0
Worrier / anxious feelings	0.3	0.5	2.8	-1.7	-0.1	0.3	0.2	0.6	0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.6	0.1	0.6	0.7	1.3	0.7	-0.8
Exposure to tobacco smoke at home	0.3	0.4	1.3	-1.1	-0.4	-0.6	-0.7	-0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	-0.9	1.1	0.6	0.5	0.5	0.3
Shortness of breath walking on level ground	0.3	0.3	1.3	1.1	0.2	0.7	0.3	0.7	0.2
Neck or shoulder pain in last month	0.3	0.4	1.6	1.2	-0.5	-0.3	-0.3	-0.3	-0.6
Medication: Seretide 50 evohaler	0.3	0.4	1.8	-1.3	-0.1	0.4	0.3	0.8	0.0
Knee pain experienced in last month	0.3	0.4	1.1	0.1	1.0	0.8	0.8	0.6	0.6
Back pain experienced in last month	0.3	0.5	1.9	1.4	0.6	0.5	0.4	0.6	0.7
Mineral and other dietary supplements	0.3	0.4	0.8	0.7	0.3	0.8	0.5	0.9	0.8
Supplements: Calcium	0.3	0.3	1.6	-0.3	-0.4	-0.2	-0.1	-0.2	-1.3
Age at First Birth	0.2	0.3	1.1	-1.1	0.5	0.2	0.8	0.1	-0.2
Rheumatoid Arthritis	0.2	0.3	1.1	-1.0	-0.5	-0.4	-0.1	-0.4	-0.4
Ulcerative Colitis	0.2	0.3	0.6	0.5	-0.4	-0.7	-0.7	-0.6	-0.4
Allergy or Eczema	0.2	0.4	1.0	0.2	-0.5	-0.6	-0.9	-1.0	-0.7
Lung FEV1/FVC ratio	0.2	1.0	3.5	1.1	-0.8	-1.0	-0.9	-0.6	-1.9
Tanning	0.2	2.2	4.9	0.5	-1.9	-1.9	-2.2	-1.7	-0.5
Average weekly spirits intake	0.2	0.3	0.7	0.8	0.2	0.7	0.5	0.7	0.3
Medication: Metformin	0.2	0.3	2.0	0.0	0.2	-0.3	0.1	-0.1	-1.4
Diabetes (father)	0.2	0.2	0.5	0.6	0.7	0.6	0.4	0.1	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.2	-1.1	0.2	0.4	-0.0	0.4	0.5
Heart attack	0.2	0.3	0.7	0.6	-0.8	-0.3	-0.8	0.1	0.1
Illnesses of siblings	0.2	0.3	0.8	-0.5	-0.5	-0.5	-0.5	-0.9	-0.2
Weight	0.2	0.7	3.5	-0.9	0.6	-0.5	-0.1	-0.4	-1.9
Worry too long after embarrassment	0.2	0.4	1.9	-1.4	0.7	0.2	0.3	0.3	-0.0
Age at first live birth	0.2	0.3	1.0	1.0	0.6	0.4	0.8	-0.1	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	0.5	0.0	0.6	0.8	0.5	0.1
Heart disease (mother)	0.2	0.2	0.5	-0.7	0.4	0.5	0.3	0.6	-0.2
Leg fat mass (right)	0.2	1.0	2.6	-0.1	1.6	0.8	1.1	1.2	-0.9
Suffer from ‘nerves’	0.2	0.3	0.9	-0.6	-1.0	-0.3	-0.7	-0.1	0.5
Age at last live birth	0.2	0.3	1.1	0.6	0.7	0.5	1.1	-0.4	0.0
Qualifications: nursing, teaching	0.2	0.3	0.6	0.1	-0.0	-0.7	-0.8	-0.7	-0.5
Breast cancer (self-reported)	0.2	0.2	0.6	0.2	-0.1	-0.6	-0.5	-0.8	-0.1
Financial situation satisfaction	0.2	0.3	1.7	0.5	0.2	0.2	-0.1	-0.2	1.3
Alcohol drinker status: Never	0.2	0.2	0.9	-1.0	0.2	-0.0	0.1	-0.0	0.5
Ever smoked	0.2	0.4	1.1	0.6	-0.6	-0.6	-1.1	-0.9	-0.2
Number of operations (self-reported)	0.2	0.3	0.7	-0.5	0.8	0.6	0.7	0.5	-0.1
Irritability	0.2	0.4	1.2	-1.0	0.0	0.6	0.2	0.4	1.1
Risk taking	0.2	0.3	1.2	-1.1	0.8	-0.3	-0.1	-0.4	-0.2
Fractured/broken bones in last 5 years	0.2	0.3	1.9	-1.4	-0.1	-0.1	-0.1	-0.0	0.2
Unable to work because of sickness or disability	0.2	0.2	1.4	-0.2	0.2	-0.0	0.2	-0.1	-1.2
Cholesterol lowering medication	0.2	0.3	1.4	1.2	-0.1	0.3	0.2	0.3	0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	1.0	-0.4	0.0	-0.6	0.4	0.4
Pack years of smoking	0.2	0.3	1.2	-0.1	0.2	0.1	0.5	0.6	-1.1
Leg fat mass (left)	0.2	0.9	2.3	-0.2	1.5	0.7	1.0	1.1	-1.0
Crohns Disease (2017)	0.1	0.3	0.9	0.4	0.4	0.5	1.0	0.9	-0.3
Irritable Bowel Disease (IBD)	0.1	0.1	0.3	0.0	0.5	0.0	0.5	0.4	-0.5
Prostate Cancer	0.1	0.1	0.5	0.7	-0.1	0.2	0.2	0.4	0.1
HbA1C	0.1	0.1	0.2	-0.5	0.1	0.4	-0.1	0.1	-0.0
Heel T-Score	0.1	0.7	3.5	1.9	0.3	0.5	0.8	0.6	-0.6
Hearing difficulty/problems: Yes	0.1	0.2	0.6	-0.6	0.5	0.1	0.5	0.1	-0.8
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.0	-0.5	-0.4	-0.4	-0.5	-0.2
Taking other prescription medications	0.1	0.1	0.3	-0.5	-0.4	-0.3	-0.2	0.3	-0.5
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	0.5	-0.6	-0.5	-0.3	-0.4	0.2
Pain all over the body in last month	0.1	0.1	0.3	0.3	-0.4	0.1	-0.6	-0.1	0.1
Hip circumference	0.1	0.6	2.5	-0.7	1.1	-0.2	0.2	0.1	-1.6
Father’s age at death	0.1	0.2	0.6	-0.3	0.8	-0.2	0.0	-0.3	-0.6
Breastfed as a baby	0.1	0.1	0.4	0.0	0.6	0.2	0.3	0.1	0.2
Tense / ‘highly strung’	0.1	0.2	0.6	-0.6	-0.6	-0.1	-0.2	0.1	0.8
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.5	-0.7	-0.3	-0.2	0.2	-0.2	-0.2
Gout (self-reported)	0.1	0.2	0.9	0.2	-0.1	-0.4	-0.5	-0.1	-1.0
Birth weight	0.1	0.1	0.3	-0.2	0.6	0.2	0.1	0.4	-0.5
Number of full brothers	0.1	0.2	0.4	0.1	-0.7	0.4	-0.1	0.6	0.5
Number of children fathered	0.1	0.1	0.4	-0.1	0.4	0.3	0.1	0.6	-0.6
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.2	0.2	0.2	-0.1	0.5	-0.5
Migraine (self-reported)	0.1	0.1	0.2	-0.0	-0.1	-0.3	-0.4	-0.5	0.3
Had major operations	0.1	0.1	0.4	0.2	-0.3	-0.1	0.0	-0.0	-0.6
Loneliness, isolation	0.1	0.2	0.5	-0.7	-0.2	0.3	-0.1	0.4	0.7
Friendships satisfaction	0.1	0.1	0.6	0.8	0.1	0.2	0.2	-0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	-0.3	-0.3	-0.4	-0.1	-0.7	-0.3
Medication: Gliclazide	0.1	0.2	0.4	-0.6	0.4	0.1	0.5	0.5	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	1.0	-1.0	-0.0	0.2	-0.1	0.4	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.3	-0.1	-0.2	-0.3	-0.5	-0.2
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.0	0.3	-0.1	-0.0	-0.0	0.1
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.3	-0.1	0.1	0.1	0.0	-0.1	-0.5
Allergy	0.0	0.1	0.3	0.1	-0.2	-0.5	-0.3	-0.2	-0.3
Number of full sisters	0.0	0.1	0.3	-0.5	-0.2	0.2	-0.1	-0.0	0.3
Medication: Aspirin	0.0	0.0	0.1	-0.2	0.2	0.0	-0.3	0.2	0.1
Medication: Aspirin	0.0	0.1	0.2	-0.1	0.3	-0.1	-0.4	0.1	-0.3
Pain experienced in last month	0.0	0.0	0.1	0.4	0.0	-0.2	-0.1	-0.3	-0.1

Hub : Genes

GOSR2

Models

Trait associations