TWAS hub - ITGB3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1200	0.0360	2.3e-06	0.079	0.066	0.064	0.078	0.074	6.6e-10	1.7e-08	2.8e-08	9.9e-10	2.7e-09
2	GTEx	Adipose Subcutaneous	0.1300	0.0400	4.0e-06	0.043	NA	0.095	NA	0.068	1.9e-04	NA	3.6e-08	NA	3.3e-06
3	METSIM	Adipose	0.0364	0.0206	8.0e-03	0.000	0.004	-0.002	0.006	-0.002	2.6e-01	6.4e-02	8.8e-01	3.5e-02	8.8e-01
4	TCGA	Breast Invasive Carcinoma	0.0713	0.0255	2.3e-06	0.032	0.033	0.024	NA	0.028	3.5e-07	1.8e-07	8.2e-06	NA	1.7e-06
5	TCGA	Brain Lower Grade Glioma	0.0698	0.0249	2.0e-07	0.028	0.073	0.057	NA	0.055	3.2e-04	1.1e-08	4.7e-07	NA	6.4e-07
6	TCGA	Prostate Adenocarcinoma	0.0444	0.0215	1.9e-03	0.000	0.011	-0.002	NA	-0.002	2.8e-01	2.2e-02	5.2e-01	NA	6.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Medication: Atorvastatin	4.7	5.8	11.7	3.4	3.1	-0.2	0.4	3.0	1.9
Systolic Blood Pressure	4.3	21.3	59.0	0.2	7.7	-6.6	-1.1	4.8	1.0
Diabetes diagnosed by doctor	4.2	6.9	14.4	3.8	2.5	2.6	0.5	3.2	1.8
Eye problems/disorders: Diabetes related eye disease	4.1	4.5	11.8	3.4	1.9	1.6	-0.7	2.7	1.0
Mouth/teeth dental problems: Mouth ulcers	4.0	6.4	21.4	1.5	4.6	0.9	1.1	3.1	1.7
Medication: Lisinopril	3.8	5.0	9.4	0.5	3.1	-2.7	1.7	3.1	0.7
Wears glasses or contact lenses	3.7	4.3	6.9	-0.0	-2.4	2.4	-2.6	-1.8	-2.0
Body Mass Index (BMI) (2010)	3.6	4.9	12.5	-2.1	-3.5	0.2	-1.1	-3.0	-1.5
Diabetes (self-reported)	3.5	5.4	10.7	3.3	2.2	2.6	0.6	2.9	1.4
Illnesses of father: Heart disease	3.5	4.8	9.4	2.9	3.1	0.3	0.4	3.1	1.3
Eye problems/disorders: Glaucoma	3.1	3.7	12.6	2.5	1.4	3.6	-0.6	1.0	0.1
Basal cell carcinoma (self-reported)	3.1	3.7	7.4	2.6	1.9	0.9	0.9	2.7	1.6
Systolic blood pressure, automated reading	2.9	8.5	26.2	0.6	5.1	-3.2	0.6	3.3	1.6
Medication: Metformin	2.8	3.9	9.4	3.1	1.4	2.4	0.3	2.2	1.2
Cardiovascular Disease	2.7	8.8	27.8	0.6	5.3	-2.6	-1.4	3.9	-0.0
Eye problems/disorders: None of the above	2.7	3.1	8.8	-2.2	-1.4	-3.0	-0.1	-1.4	-0.9
Medication: Seretide 50 evohaler	2.7	3.2	7.7	-0.7	-0.7	1.5	-2.8	-1.3	-2.5
Medication: Ramipril	2.6	3.3	12.4	-0.1	-1.1	1.1	-3.5	-1.1	-2.0
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.2	7.3	-2.7	-1.5	-2.1	-2.1	-2.2	-1.5
Medication: Amlodipine	2.6	3.7	11.3	-1.5	-0.0	-1.7	-3.4	-1.1	-2.1
High cholesterol (Self-reported)	2.6	4.5	10.3	2.6	2.8	0.5	-1.1	3.2	0.8
Mouth/teeth dental problems	2.4	3.8	7.1	-2.7	-2.5	-1.6	0.3	-2.2	-1.4
Glaucoma (self-reported)	2.4	2.9	9.9	2.0	0.6	3.2	-1.5	0.5	-0.6
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	5.2	-2.3	-1.6	1.8	-1.2	-1.8	-1.4
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	4.5	1.9	2.1	2.0	0.2	1.8	1.1
Ever depressed for a whole week	2.3	2.8	6.2	2.1	2.0	0.9	0.3	2.5	1.1
Medication: Co-codamol	2.2	2.6	5.9	0.1	-2.3	1.5	-2.4	-0.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	6.5	-2.5	-1.3	-1.5	-0.7	-2.3	-0.6
Alcohol usually taken with meals	2.1	3.4	8.2	-1.9	-2.9	-1.4	0.1	-2.3	-1.2
Hair/balding pattern: Pattern 3	2.0	2.9	6.8	-1.9	-2.6	-1.1	-0.3	-1.9	-1.6
Waist Hip Ratio (WHR)	1.9	8.6	17.1	4.1	3.0	3.6	-1.2	3.2	0.8
Chronotype (morning person)	1.9	4.3	11.0	-2.5	-1.2	-0.3	-1.7	-3.3	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	6.3	-2.4	-1.1	-0.6	-2.5	-1.8	-0.9
Hearing difficulty/problems with background noise	1.9	3.0	8.8	-1.0	-2.1	0.4	-3.0	-1.1	-1.6
Father’s age at death	1.9	2.5	4.7	-2.2	-2.1	-0.7	-0.3	-2.0	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.3	6.0	-1.3	-2.4	1.1	-1.0	-1.5	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.6	1.6	1.9	-0.9	1.8	1.2	1.4
Angina	1.8	2.4	6.1	2.5	1.8	0.3	-1.6	1.5	-0.2
Impedance of arm (left)	1.8	8.3	16.3	1.2	3.4	-4.0	2.5	3.3	1.8
Bipolar Disorder (2018)	1.7	2.7	5.2	1.7	1.9	0.6	1.6	1.2	2.3
Alzheimer’s Disease (in mother)	1.7	2.0	3.6	-1.5	-1.8	0.4	-1.2	-1.9	-1.3
Hearing difficulty/problems: Yes	1.7	2.7	11.4	1.2	-1.1	0.9	-3.4	0.0	-1.1
Medication: Simvastatin	1.7	2.5	4.0	1.8	1.3	2.0	-1.9	1.6	-0.2
Bipolar Disorder (2011)	1.6	1.5	3.6	1.0	1.3	1.9	1.5	0.2	0.6
Medication for hormone replacement therapy	1.6	1.8	5.5	-1.5	-0.9	-0.1	2.3	-1.4	0.5
Impedance of arm (right)	1.6	7.4	15.2	0.8	2.8	-3.9	2.8	3.0	1.9
Happiness	1.6	1.9	3.7	1.6	1.1	1.9	-0.9	1.3	1.2
Angina (self-reported)	1.6	2.0	5.3	2.3	1.4	0.5	-1.8	1.1	-0.5
Supplements: Vitamin C	1.6	1.9	3.7	-1.5	-1.9	1.3	-0.8	-1.4	-1.1
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.5	-1.9	-1.7	-0.1	1.3	-1.6	-0.5
Age started oral contraceptive pill	1.6	2.0	4.9	0.7	2.2	-0.8	1.3	1.6	1.2
Cholesterol lowering medication	1.6	2.4	4.6	2.1	2.0	0.5	-0.6	2.1	0.8
Diabetes (father)	1.5	1.9	4.1	1.6	1.1	0.8	-1.5	2.0	0.7
Time employed in main current job	1.5	1.7	6.5	-0.6	-0.2	-1.6	2.5	-0.1	0.9
Commuting to job workplace: Cycle	1.5	1.8	4.5	0.9	1.3	-2.1	0.0	1.6	1.1
Impedance of whole body	1.5	7.6	11.4	1.0	3.4	-3.3	3.1	3.1	1.8
Alzheimer’s Disease (including proxy)	1.4	2.0	4.0	-0.9	-2.0	0.6	-1.8	-1.6	-1.1
Type 2 Diabetes (T2D) (2018)	1.4	2.6	6.0	2.4	1.2	1.6	-0.9	2.1	0.4
High blood pressure	1.4	3.8	8.4	-0.3	2.9	-1.8	-2.2	2.1	-1.3
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.4	-0.7	-1.9	0.2	-0.9	-1.9	-2.1
Comparative body size at age 10	1.4	4.0	6.7	-2.1	-1.9	0.5	-1.8	-2.6	-2.3
Illness, injury, bereavement, stress in last 2 years	1.4	1.8	3.4	-0.9	-1.6	-0.5	-1.1	-1.6	-1.9
Ever taken oral contraceptive pill	1.4	1.6	4.6	-1.8	-2.2	-0.0	-0.1	-1.1	-0.6
Vascular/heart problems diagnosed by doctor	1.4	3.9	8.1	-0.4	-2.9	2.0	2.3	-2.1	1.1
Alzheimer’s Disease (in father)	1.3	1.4	2.7	0.0	-1.5	0.9	-1.6	-0.7	-1.6
Coronary Artery Disease (CAD)	1.3	1.6	7.1	-0.5	2.7	-0.5	0.9	0.8	0.6
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	3.0	-0.3	1.2	-1.6	1.7	0.4	1.3
Medication: Levothyroxine sodium	1.3	2.2	8.0	0.9	0.1	-1.9	0.4	0.5	2.8
Medication: Blood pressure	1.3	2.2	7.2	-0.6	0.6	-1.3	-2.7	0.1	-1.9
Medication: Ibuprofen	1.3	1.6	2.5	-1.5	-0.8	1.6	-1.5	-0.7	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	4.0	-2.0	-1.4	-0.8	-0.5	-1.4	-0.8
Hearing aid user	1.3	1.5	2.6	1.6	1.6	-0.3	-1.2	1.1	1.0
Reaction Time	1.2	2.3	7.2	0.4	-0.0	2.7	1.9	-1.6	0.6
LDL Cholesterol	1.2	1.9	9.6	-0.1	0.4	3.1	-0.2	0.0	-1.3
Schizophrenia (2014)	1.2	2.6	7.0	2.1	0.3	2.6	1.3	-0.0	1.5
Severe depression (siblings)	1.2	1.4	2.5	-1.4	-1.6	0.4	-1.3	-1.1	-1.1
Medication: Lansoprazole	1.2	1.3	4.4	1.5	0.7	2.1	0.8	0.2	0.4
Length of working week for main job	1.2	1.3	2.4	0.5	-1.6	1.5	-1.4	-0.3	-0.9
Pulse wave reflection index	1.2	1.4	3.0	-1.5	-0.5	-1.0	-1.7	-0.8	-1.3
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	7.4	-0.4	-0.4	-2.2	1.2	-0.3	2.7
Exposure to tobacco smoke outside home	1.2	1.6	2.4	1.3	1.5	0.9	1.2	0.8	1.5
Pulse wave peak to peak time	1.2	1.5	2.9	1.7	1.1	0.3	1.2	1.3	1.2
Chest pain or discomfort	1.2	1.7	2.5	1.6	1.4	0.7	-1.6	1.3	-1.1
Hypertension (Self-reported)	1.2	3.3	6.2	-0.5	2.5	-1.8	-2.2	1.8	-1.4
Average weekly red wine intake	1.2	1.8	6.9	0.5	-2.6	0.4	-0.5	-1.7	-0.8
Illnesses of father: High blood pressure	1.2	1.5	3.1	-0.7	-0.5	-0.9	-1.8	-1.7	-1.3
Ever smoked	1.2	2.2	5.6	-2.4	-1.3	-1.6	0.2	-1.6	-0.5
Verbal and Numeric Reasoning (VNR)	1.1	2.7	6.6	1.4	-2.6	1.8	-1.6	-0.3	-1.4
Lupus	1.1	1.6	6.0	-1.3	-1.0	0.0	-0.7	-0.6	-2.4
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.6	-1.7	-0.4	-1.0	-1.9	-1.1	-0.3
Current tobacco smoking	1.1	1.7	3.8	-2.0	-1.0	-1.1	0.1	-1.9	-0.9
Serious illness, injury or assault to yourself	1.1	1.3	4.6	0.2	2.1	-0.7	0.4	1.3	0.9
Illnesses of siblings	1.1	1.6	3.5	-1.9	-1.4	1.6	0.9	-0.9	-0.4
Qualifications: A levels/AS levels or equivalent	1.1	2.4	5.0	0.9	-1.9	0.9	-2.2	0.9	-1.8
Medication: Cholesterol lowering	1.1	1.7	4.3	1.5	2.1	0.7	-0.5	1.7	0.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	5.6	-0.4	-2.4	0.7	1.1	-1.9	0.2
Eye problems/disorders: Cataract	1.1	1.3	2.7	0.9	1.1	0.8	1.6	0.3	1.4
Smoking status: Current	1.1	1.7	3.7	-1.9	-0.8	-1.3	0.7	-1.7	-0.8
Medication: Blood pressure	1.1	2.1	4.0	1.1	2.0	-1.1	-1.5	2.0	-0.1
Medication: Bendroflumethiazide	1.1	1.6	3.4	0.0	1.4	-1.8	-1.0	1.8	0.2
Myopia	1.1	1.6	3.9	-0.3	-0.9	1.2	-2.0	-1.3	-1.4
Bipolar Disorder or Schizophrenia	1.0	2.4	6.3	2.0	0.6	2.5	1.4	-0.1	1.3
Schizophrenia vs Biploar Disorder	1.0	1.4	2.6	-0.8	-1.6	0.2	-1.1	-1.2	-1.5
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.2	1.0	1.5	-1.1	-0.5	1.4	0.6
Hypothyroidism (self reported)	1.0	2.3	6.9	-0.1	-1.2	-2.6	-0.1	-0.6	2.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.0	-1.0	-1.7	-0.0	-0.9	-1.7	-0.3
Impedance of leg (right)	1.0	5.0	11.9	0.5	2.6	-2.0	3.4	2.1	1.7
Stomach or abdominal pain in last month	1.0	1.2	3.5	-0.4	1.9	-0.3	0.5	1.2	1.4
Supplements: Glucosamine	1.0	1.3	2.1	1.4	-0.0	1.0	1.4	0.8	1.5
Medication: Atenolol	1.0	1.2	2.8	1.7	1.2	0.9	-1.1	1.1	-0.2
Impedance of leg (left)	1.0	4.8	9.7	0.6	2.6	-2.0	3.1	2.2	1.7
Nervous feelings	1.0	1.8	6.1	-2.5	-0.5	-0.7	-0.4	-1.3	-1.5
Pulse wave Arterial Stiffness index	1.0	1.2	2.5	-1.6	-0.9	-0.6	-1.2	-0.9	-1.0
Loud music exposure frequency	1.0	1.1	4.8	-0.8	0.2	-0.5	2.2	0.1	0.8
Medication: Paracetamol	1.0	1.7	4.6	-0.3	1.4	2.1	-1.2	1.5	-0.1
Commuting to job workplace: Public transport	1.0	1.2	3.5	-0.2	-1.1	0.1	-0.6	-1.9	-1.4
Fractured/broken bones in last 5 years	1.0	1.3	2.6	-1.4	-1.2	-0.4	-0.7	-1.6	-1.1
Schizophrenia (2018)	0.9	1.9	7.6	1.3	-0.8	2.8	0.5	-1.1	-0.1
Worry (Nagel 2018)	0.9	1.8	4.9	-2.2	0.2	-0.6	1.7	-1.6	0.0
Prostate Cancer	0.9	1.2	3.7	0.5	0.6	-1.6	1.9	0.4	0.5
Primary Biliary Cirrhosis	0.9	1.3	4.7	1.2	-1.1	0.6	-2.2	0.4	-0.4
Average weekly fortified wine intake	0.9	1.0	1.5	-1.2	-1.1	0.5	-1.2	-0.7	-1.1
Alcohol intake versus 10 years previously	0.9	1.3	1.8	1.3	1.1	1.1	0.3	1.3	1.3
Pulse rate	0.9	1.5	2.8	-0.9	-1.7	0.9	1.3	-1.7	0.4
Noisy workplace	0.9	1.1	3.4	0.4	1.8	0.5	1.2	0.9	0.6
Birth weight of first child	0.9	1.6	4.4	-1.3	-2.1	0.1	0.8	-1.6	-0.3
High blood pressure (siblings)	0.9	1.3	2.6	1.0	1.1	-1.6	-1.6	0.6	-0.5
Health satisfaction	0.9	1.2	4.7	-0.4	0.0	0.2	-2.2	-0.6	-1.4
Mean time to correctly identify matches	0.9	1.7	4.0	0.5	-0.7	2.0	1.5	-1.8	0.7
Osteoarthritis (self-reported)	0.9	1.2	3.1	0.8	-1.0	1.8	-1.2	0.8	-0.7
Number of self-reported non-cancer illnesses	0.9	1.6	3.3	0.6	1.8	-0.4	-1.5	1.8	0.2
Average weekly beer plus cider intake	0.9	1.3	3.7	-0.3	1.3	-0.7	1.9	0.3	1.4
Depression (Nagel 2018)	0.8	1.2	3.5	-1.9	-0.3	-1.1	-0.1	-1.5	0.2
Lung FEV1/FVC ratio	0.8	4.2	13.6	3.7	1.0	1.6	-1.3	2.4	0.6
Diabetes (mother)	0.8	1.0	2.0	1.2	1.1	-0.6	-0.0	1.4	0.9
Pack years adult smoking proportion	0.8	1.2	2.2	1.5	1.1	0.7	-0.3	1.4	1.1
Townsend deprivation index at recruitment	0.8	1.2	3.9	-1.0	-0.8	0.2	-2.0	-0.1	-1.2
High blood pressure (mother)	0.8	1.1	3.7	-1.3	0.3	-1.9	-0.8	-0.6	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	4.8	-0.3	-0.6	2.2	0.2	-0.0	-0.6
Mouth/teeth dental problems: Dentures	0.8	1.4	4.9	1.1	-0.5	1.4	-2.2	-0.4	0.1
Hair/balding pattern: Pattern 4	0.8	1.9	3.8	0.3	1.4	-2.0	1.5	1.0	1.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.0	0.1	1.4	0.9	-0.9	1.2	1.0
Number of full brothers	0.8	1.0	2.2	1.2	1.0	0.2	1.0	0.5	1.5
Medication: Omeprazole	0.8	0.9	3.3	0.4	0.8	-1.0	1.8	0.1	0.7
Arm predicted mass (right)	0.8	3.9	10.7	0.1	-3.3	1.4	-2.6	-1.8	-0.7
Medication for cholesterol	0.8	1.2	3.3	-0.4	-1.8	1.5	-0.0	-1.1	-0.4
Rheumatoid Arthritis	0.7	0.9	2.6	-0.1	-0.8	1.6	-1.0	-0.4	-1.0
Lung FVC	0.7	3.4	12.5	-0.6	0.8	-2.4	3.5	-0.3	1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.5	0.8	-0.0	0.7	1.3	0.4	1.6
Maternal smoking around birth	0.7	1.0	1.7	-0.4	0.3	1.3	1.3	0.8	1.3
Age when periods started (menarche)	0.7	1.6	5.4	-0.6	0.5	-1.3	0.7	1.2	2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	4.9	-0.2	2.2	-1.3	0.0	1.7	0.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.5	0.2	1.2	-0.5	0.8	1.0	1.0
Had menopause	0.7	0.8	1.6	-0.8	-1.2	0.8	0.7	-1.3	-0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.3	1.0	0.2	0.7	-1.8	0.8	0.2
Trunk fat-free mass	0.7	4.1	13.5	-0.2	-3.7	1.0	-2.6	-1.6	-0.5
Hip circumference	0.7	3.1	9.0	-0.2	-2.4	-0.9	-3.0	-1.6	-0.4
Trunk predicted mass	0.7	4.1	13.8	-0.3	-3.7	1.0	-2.6	-1.6	-0.6
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.2	1.5	0.6	0.6	0.5	1.1	1.0
Birth weight	0.7	1.5	3.6	-0.0	-1.9	1.3	-1.5	-1.0	-0.5
Arm fat-free mass (right)	0.7	3.7	10.4	0.3	-3.2	1.6	-2.6	-1.5	-0.4
Whole body fat-free mass	0.7	3.8	11.6	0.3	-3.4	1.1	-2.9	-1.3	-0.2
Long-standing illness, disability or infirmity	0.7	1.1	3.1	0.9	1.8	0.1	-0.7	1.4	0.7
Whole body water mass	0.7	3.8	11.6	0.2	-3.4	1.1	-2.9	-1.4	-0.3
Medication: Paracetamol	0.7	1.1	2.4	0.1	1.2	1.5	-0.9	1.4	0.2
Number of operations (self-reported)	0.7	1.0	2.3	-0.1	-1.5	1.4	-0.8	-0.9	0.7
Unable to work because of sickness or disability	0.7	0.9	2.9	-1.7	-0.6	-0.8	-0.3	-1.1	-0.8
Supplements: Calcium	0.7	0.7	1.6	0.7	0.9	1.3	0.3	0.4	1.1
Heart disease (siblings)	0.7	0.8	1.9	1.0	1.2	-1.4	-0.3	0.7	-0.2
Pack years of smoking	0.7	1.0	2.2	1.5	0.8	0.5	-0.7	1.2	1.1
Intelligence (Savage-Jansen 2018)	0.6	1.9	5.9	0.6	-2.4	0.1	-1.5	-0.1	-1.6
Crohns Disease (2012)	0.6	0.9	3.6	0.2	-1.9	0.3	-0.6	-1.2	-0.3
Ulcerative Colitis	0.6	0.9	2.0	-0.6	-1.4	-1.0	-0.8	-1.1	-0.4
BMI	0.6	3.3	6.8	-0.8	-2.2	-0.1	-2.6	-2.6	-1.0
Smoking Status	0.6	1.5	3.7	-1.9	-0.5	-0.8	1.9	-0.8	0.5
Ever had hysterectomy (womb removed)	0.6	0.7	2.0	1.0	-0.8	1.4	-0.6	0.2	-0.5
Vitamin and mineral supplements	0.6	0.8	2.0	1.4	0.7	0.3	1.3	0.4	0.1
Qualifications: CSEs or equivalent	0.6	0.8	3.2	0.2	1.8	-1.1	0.0	0.2	0.3
Leg predicted mass (left)	0.6	3.0	9.0	0.9	-2.6	0.9	-3.0	-0.7	0.1
Waist circumference	0.6	2.0	8.0	1.6	-0.2	1.3	-2.8	-0.1	-0.0
Forced vital capacity (FVC)	0.6	2.4	8.0	0.1	0.5	-2.8	1.8	0.9	1.5
Qualifications: None of the above	0.6	1.2	3.5	-0.3	1.0	-1.1	1.2	-0.0	1.9
Number of live births	0.6	0.9	1.8	-1.1	-0.1	-0.2	-1.0	-1.1	-1.4
Lung cancer (father)	0.6	0.7	2.2	0.9	-0.5	1.5	-0.1	0.8	0.1
Emphysema/chronic bronchitis	0.6	0.7	3.2	0.6	-0.1	1.8	0.3	-0.1	0.6
Suffer from ‘nerves’	0.6	1.0	2.6	-1.6	-0.5	-0.4	0.5	-1.5	-0.5
Had major operations	0.6	0.6	1.8	0.7	-0.2	1.3	-0.4	0.1	1.2
Leg fat-free mass (right)	0.6	3.2	10.0	0.8	-2.7	0.9	-3.2	-0.7	-0.0
Breast cancer (self-reported)	0.6	0.7	2.2	1.5	0.8	0.3	-0.5	1.0	0.4
Leg predicted mass (right)	0.6	3.2	10.0	0.8	-2.7	0.9	-3.2	-0.7	-0.0
Financial situation satisfaction	0.6	0.7	2.8	-0.0	1.7	-0.3	0.6	0.8	0.5
Irritability	0.6	1.0	2.3	0.4	1.5	0.8	1.0	1.2	0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.9	1.4	0.8	-0.3	-1.0	0.9	0.5
Arm predicted mass (left)	0.6	3.0	9.9	-0.1	-3.1	1.4	-2.0	-1.5	0.0
Neuroticism (Nagel 2018)	0.5	1.2	2.0	-1.4	1.3	-0.7	1.4	-0.4	0.9
Ulcerative Colitis (UC)	0.5	0.9	1.6	-0.9	-1.0	-1.3	-1.1	-0.9	-0.3
Breast Cancer	0.5	1.3	3.5	-1.1	-1.9	1.3	-0.6	-1.1	0.1
HDL Cholesterol	0.5	0.9	2.1	0.0	1.5	-0.5	-0.6	1.5	-0.6
Neuroticism (2016)	0.5	0.7	1.6	-1.2	0.6	-1.3	-0.8	0.2	-0.3
Respiratory disease	0.5	1.1	2.6	-1.5	0.3	0.6	-0.6	-1.0	-1.6
Neuroticism	0.5	1.1	3.7	-1.9	0.3	-0.9	0.5	-1.3	-0.0
Number of treatments/medications taken	0.5	0.9	3.1	-0.2	1.3	-0.2	-1.8	0.7	-0.5
Average weekly spirits intake	0.5	0.6	1.9	-0.0	-1.4	-0.0	-0.6	-0.5	-1.0
Leg fat-free mass (left)	0.5	2.8	8.0	0.8	-2.6	0.8	-2.8	-0.7	0.2
Hand grip strength (right)	0.5	1.2	3.5	1.9	-1.4	1.3	-0.4	-0.3	0.2
Multivitamins +/- minerals	0.5	0.6	2.5	-1.6	-0.3	-0.7	-0.8	0.1	0.1
Number of incorrect matches in round	0.5	0.8	2.5	-1.6	-0.4	-1.2	0.8	-0.1	-0.2
Hair/balding pattern: Pattern 2	0.5	0.6	2.4	0.7	0.4	1.6	-0.3	0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.3	-0.9	1.5	-1.2	0.7	1.3	0.5
Heart attack	0.5	0.7	2.2	1.5	0.6	0.0	-0.9	0.7	0.4
Pain all over the body in last month	0.5	0.5	1.2	-1.1	-0.0	-0.6	-0.5	-0.5	-1.1
Fluid intelligence score	0.5	1.1	2.0	1.3	-1.4	1.0	-1.3	0.4	-0.2
Illnesses of mother	0.5	0.6	1.2	0.5	-0.9	1.1	-0.4	0.6	-0.9
Tense / ‘highly strung’	0.5	0.8	2.8	-1.7	-0.6	-0.3	0.1	-1.1	-0.5
Forced vital capacity (FVC), Best measure	0.5	1.8	8.7	-0.2	-0.4	-3.0	1.1	0.4	0.5
Worry too long after embarrassment	0.5	0.8	1.7	1.1	1.3	0.7	-0.4	1.2	0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.0	-0.5	-0.7	-0.5	-0.2	-1.4	-0.8
Medication for pain relief, constipation, heartburn	0.5	0.8	2.9	-0.0	-1.1	-1.7	0.5	-0.6	0.6
Pulse rate, automated reading	0.5	1.5	4.8	1.3	-1.6	2.2	0.2	-0.4	0.1
Overall health rating	0.5	1.1	3.1	0.6	1.8	-0.7	-1.0	1.3	0.3
Medication: Aspirin	0.5	0.6	1.3	1.1	1.1	0.0	-0.5	0.7	-0.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	-0.7	-0.8	-0.1	1.4	-0.5	-0.2
Ever had bowel cancer screening	0.5	0.6	1.8	0.0	0.3	-1.4	0.6	0.7	1.0
Friendships satisfaction	0.5	0.7	1.5	1.2	0.4	1.1	-0.3	1.0	0.2
Commuting to job workplace: Walk	0.5	0.6	1.5	-0.0	0.6	-1.1	1.2	-0.4	-0.2
Medication: Aspirin	0.5	0.6	1.5	1.2	1.2	0.1	-0.4	0.9	-0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	-0.7	-1.2	1.2	-0.3	-0.4	-0.1
Mother’s age at death	0.5	0.6	1.7	-0.8	-1.3	-0.9	0.5	0.2	0.5
Alcohol drinker status: Never	0.5	0.6	1.2	-0.7	-0.2	-1.0	0.9	-1.1	0.1
Basal metabolic rate	0.5	3.0	8.2	0.5	-2.9	1.0	-2.8	-1.0	0.1
Arm fat-free mass (left)	0.5	2.6	8.1	0.1	-2.8	1.4	-2.0	-1.3	0.1
Allergy or Eczema	0.4	1.0	2.8	-0.7	-1.6	-0.4	-0.2	-1.7	-0.1
Hand grip strength (left)	0.4	1.0	1.4	1.1	-1.2	1.1	1.0	-0.8	0.6
Relative age of first facial hair	0.4	0.9	2.2	1.0	1.5	0.4	-1.1	0.9	0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.2	-0.2	0.6	-0.3	1.1	0.6	0.8
Falls in the last year	0.4	0.6	1.9	-1.4	0.6	-0.8	0.5	0.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.7	1.2	0.5	-1.6	0.7	1.4	1.0
Asthma	0.4	0.8	2.0	-1.4	1.3	0.3	-0.3	-0.2	-1.1
Depression (self-reported)	0.4	0.5	2.7	-1.7	0.1	-0.2	-0.1	-0.5	0.3
Exposure to tobacco smoke at home	0.4	0.4	0.8	-0.7	-0.8	-0.2	-0.2	-0.9	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.3	-1.0	1.5	-0.4	0.1	0.7	0.2
Headache pain in last month	0.4	0.7	2.3	-0.9	0.1	1.5	-1.0	-0.4	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	2.2	-1.5	-0.0	0.2	-1.0	-0.2	-0.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.8	-0.5	1.3	1.0	1.1	-0.1	0.4
Medication: Allopurinol	0.4	0.5	2.5	-0.3	0.4	-0.2	1.6	0.2	0.5
Number of full sisters	0.4	0.4	1.3	0.4	1.0	-0.3	-1.2	0.3	-0.2
Family relationship satisfaction	0.4	0.5	1.6	0.4	1.3	0.0	0.1	0.4	1.0
Illnesses of siblings: Diabetes	0.4	0.4	1.5	0.8	-0.0	0.5	-1.2	-0.1	-0.3
Asthma (self-reported)	0.4	0.8	2.0	-1.4	1.0	0.3	-0.2	-0.4	-1.1
Medication: Gliclazide	0.4	0.4	1.2	0.8	0.5	0.3	-1.1	0.5	-0.3
Guilty feelings	0.4	0.6	1.6	0.3	1.2	1.0	-0.6	0.5	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	-0.3	-1.1	0.8	-0.2	-1.0	-0.3
Risk taking	0.4	0.7	1.8	-1.0	-0.0	-1.3	0.7	-0.7	0.5
Diastolic blood pressure, automated reading	0.4	1.4	3.9	-0.3	1.7	-2.0	0.2	1.1	0.1
Irritable Bowel Disease (IBD)	0.3	0.8	2.0	-0.5	-1.3	-0.4	-1.4	-0.7	0.1
Age at First Birth	0.3	0.4	1.5	0.9	-0.1	-1.2	-0.3	0.3	0.1
HbA1C	0.3	0.3	0.6	-0.2	0.7	-0.8	-0.5	0.1	-0.6
Blood Eosinophil Count	0.3	2.6	11.8	-0.0	1.6	1.1	3.4	0.4	-0.1
Height	0.3	6.1	17.0	-0.5	-4.0	-4.1	-1.6	-0.1	0.9
Hair Pigment	0.3	7.2	23.4	4.8	2.4	1.2	2.8	1.7	1.4
Trunk fat percentage	0.3	1.2	1.8	1.3	1.0	-1.3	-0.8	0.8	1.2
Fed-up feelings	0.3	0.5	2.3	-0.5	0.7	0.4	-1.5	0.3	0.2
Relative age voice broke	0.3	0.4	1.3	0.8	1.1	0.6	-0.2	-0.0	-0.0
Sitting height	0.3	2.5	4.2	1.1	-1.7	-1.6	1.6	1.2	2.0
Chronic bronchitis/emphysema (father)	0.3	0.4	1.3	0.0	0.3	-1.2	0.2	0.7	0.4
Body mass index (BMI)	0.3	1.4	5.2	0.5	-0.6	1.4	-2.3	-1.0	-0.2
Past tobacco smoking	0.3	0.6	1.0	1.0	0.9	0.8	-0.6	1.0	-0.1
Allergy	0.3	0.6	1.5	0.8	0.4	-0.7	0.7	1.2	0.6
Weight	0.3	1.5	5.1	0.8	-1.5	0.3	-2.3	-0.5	0.6
Breastfed as a baby	0.3	0.4	0.9	-0.7	-1.0	-0.2	-0.6	-0.8	-0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-0.7	1.0	0.0	-0.3	-0.3	-0.7
Body fat percentage	0.3	1.2	2.0	1.4	1.2	-0.8	-0.9	0.9	1.3
Number of children fathered	0.3	0.3	0.6	0.7	0.1	0.8	-0.8	-0.1	-0.1
Age at first live birth	0.3	0.5	2.0	0.8	0.1	0.4	0.0	1.4	0.2
Shortness of breath walking on level ground	0.3	0.4	1.1	-1.1	0.2	-0.4	0.7	-0.4	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.1	0.1	0.3	1.0	0.6	0.1	0.6
Whole body fat mass	0.3	1.1	3.8	1.3	-0.1	-0.4	-2.0	0.2	0.8
Alcohol intake frequency.	0.3	0.7	1.2	0.2	1.1	-1.1	0.5	-0.2	1.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.8	0.2	0.3	0.7	-0.8	0.9	0.5
Arm fat percentage (left)	0.3	1.2	2.4	1.3	1.2	-0.7	-1.6	0.7	0.6
Loneliness, isolation	0.3	0.4	0.9	0.9	0.4	-0.2	-1.0	0.7	-0.1
Qualifications: nursing, teaching	0.3	0.4	1.3	0.2	-0.7	-1.1	0.2	0.9	-0.2
Osteoporosis (self-reported)	0.3	0.4	0.9	-0.8	-0.1	0.3	-0.5	-1.0	-0.8
Arm fat mass (left)	0.3	1.1	4.5	1.3	0.1	-0.0	-2.1	0.3	0.5
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	-0.9	0.7	-0.1	0.3	-0.6	0.9
Crohns Disease (2017)	0.2	0.4	0.8	0.6	-0.2	0.8	-0.9	0.2	0.5
Major Depression (MDD)	0.2	0.3	0.7	-0.8	0.7	-0.2	0.3	-0.5	-0.5
Ovarian Cancer	0.2	0.3	0.7	0.5	-0.4	-0.1	0.0	-0.8	0.8
Mean Putamen Volume	0.2	0.3	0.9	-0.1	-0.9	0.3	-0.4	-0.7	-0.2
Fasting Glucose	0.2	0.3	1.0	0.4	1.0	-0.0	-0.1	0.8	0.1
Triglycerides	0.2	0.3	0.7	-0.5	0.2	-0.8	-0.7	-0.6	-0.1
Blood Platelet Count	0.2	2.3	6.8	0.7	2.0	0.0	-1.1	2.6	1.2
Blood Red Count	0.2	2.4	6.1	-1.4	2.5	-1.5	-1.6	-1.2	-0.1
Blood White Count	0.2	1.8	3.2	-1.8	-1.6	-0.5	-0.3	-1.8	-1.1
Supplements: Zinc	0.2	0.2	0.7	0.1	0.6	0.8	0.3	-0.0	0.4
Taking other prescription medications	0.2	0.3	0.5	0.6	0.7	0.3	-0.7	0.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.1	-0.5	0.7	0.1	-0.4	0.7
Trunk fat mass	0.2	0.9	2.7	1.1	-0.2	-1.0	-1.6	0.1	0.9
Financial difficulties in last 2 years	0.2	0.3	1.1	-1.1	-0.1	-0.4	0.4	-0.4	0.4
Arm fat percentage (right)	0.2	0.9	1.6	1.1	1.1	-0.6	-1.3	0.7	0.7
Worrier / anxious feelings	0.2	0.4	0.7	-0.8	0.7	-0.3	0.9	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.5	0.5	-0.5	-1.9	0.0	0.5	0.1
Arm fat mass (right)	0.2	1.0	4.7	1.1	-0.3	0.1	-2.2	-0.1	0.3
Standing height	0.2	2.4	5.1	0.8	-2.1	-2.2	-0.2	1.0	1.7
Peak expiratory flow (PEF)	0.2	0.4	1.5	0.5	-0.2	-0.4	-0.3	1.2	0.4
Blood clot in the leg (DVT)	0.2	0.2	0.6	0.1	0.2	-0.6	0.8	0.3	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.4	0.7	-0.4	0.7	-0.2	0.1
Qualifications: College or University degree	0.2	0.7	1.8	1.3	-0.8	-0.4	-0.3	1.0	0.5
Neck or shoulder pain in last month	0.2	0.2	0.5	-0.2	0.6	-0.1	0.6	0.7	0.4
Leg fat mass (right)	0.2	0.9	2.3	1.2	-0.2	0.7	-1.5	0.1	1.1
Comparative height size at age 10	0.2	1.0	3.9	0.9	-2.0	-0.1	-1.2	-0.2	-0.1
Age at last live birth	0.2	0.3	1.3	0.4	0.3	0.4	0.2	1.1	0.3
Leg pain on walking	0.2	0.2	0.5	-0.1	0.7	0.7	-0.4	0.4	0.2
Knee pain experienced in last month	0.2	0.4	1.1	-0.4	1.0	1.0	-0.1	-0.0	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.4	0.5	-0.2	0.6	-0.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	1.6	-0.2	-1.3	-0.4	-0.3	-0.2	0.0
Mood swings	0.2	0.4	1.4	0.1	1.2	0.3	-0.4	-0.1	1.0
Back pain experienced in last month	0.2	0.3	1.1	-1.0	0.2	-0.9	0.1	0.4	0.0
Mineral and other dietary supplements	0.2	0.2	0.6	-0.5	0.2	-0.8	-0.2	0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.6	1.3	-0.2	-0.8	-0.2	0.4	-0.1
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.2	-0.7	-1.0	-0.5	0.5	0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	-0.5	-0.4	0.7	-0.2	0.2	0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	0.1	-0.2	-0.3	-0.3	-1.0	-0.6
Pain experienced in last month	0.2	0.3	1.1	1.0	-0.2	-0.6	-0.3	0.2	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	0.1	0.1	-0.5	0.9	0.2	0.4
Alcohol drinker status: Previous	0.2	0.3	0.9	-0.5	-0.6	-1.0	0.2	-0.3	0.0
Leg fat mass (left)	0.2	1.0	3.2	1.0	-0.5	0.7	-1.8	-0.2	0.9
Heel T-Score	0.1	1.2	2.0	-0.0	1.4	1.4	1.3	0.7	0.9
Sensitivity / hurt feelings	0.1	0.3	0.9	-0.9	0.6	0.1	0.1	-0.4	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.0	-0.2	-0.8	0.2	-0.2	-1.0	0.1
Had other major operations	0.1	0.1	0.2	0.0	0.4	0.5	-0.4	0.4	0.3
Neuroticism score	0.1	0.3	0.6	-0.8	0.6	0.8	0.3	-0.4	0.1
Prospective memory result	0.1	0.2	0.3	-0.4	-0.5	0.5	0.4	-0.5	0.2
Gout (self-reported)	0.1	0.2	0.4	0.0	-0.5	0.6	0.2	-0.4	-0.3
Leg fat percentage (right)	0.1	0.4	1.3	0.8	0.6	0.3	-0.3	0.1	1.1
Migraine (self-reported)	0.1	0.1	0.2	-0.3	-0.2	-0.3	-0.3	0.1	-0.4
Heart disease (mother)	0.1	0.1	0.6	-0.1	-0.1	0.3	0.2	-0.8	0.0
Smoking status: Previous	0.1	0.2	0.5	-0.1	-0.3	0.4	0.6	0.0	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.6	0.0	-0.2	0.3	0.8	-0.3	0.4
Miserableness	0.1	0.2	0.7	0.1	-0.1	0.6	-0.8	-0.1	0.1
Leg fat percentage (left)	0.1	0.4	0.9	0.8	0.6	0.4	-0.5	0.1	1.0
Tanning	0.0	0.2	0.6	0.1	-0.1	-0.8	0.7	-0.1	0.5

Hub : Genes

ITGB3

Models

Trait associations