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chr7:98,244,565-102,866,033

Best TWAS P=1.67e-21 · Best GWAS P=7.09e-22 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CPSF4	0.06	0.06	blup	313	0.07	6.6e-09	8.49	5.8	4.9e-09	0.08	0.06	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LOC100289187	0.08	0.02	enet	14	0.03	4.5e-05	7.43	-6.3	2.2e-10	-0.17	0.09	0.91	TRUE
3	GTEx	Adipose Visceral Omentum	GS1-259H13.2	0.23	0.12	lasso	1	0.09	1.8e-05	7.55	-7.5	4.2e-14	-0.24	0.86	0.04	FALSE
4	GTEx	Adrenal Gland	STAG3L5P-PVRIG2P-PILRB	0.32	0.25	enet	43	0.20	7.0e-08	-3.32	-6.3	2.6e-10	-0.09	0.99	0.00	TRUE
5	GTEx	Artery Aorta	ACHE	0.35	0.31	enet	35	0.32	1.9e-18	8.15	7.5	5.3e-14	0.04	0.01	0.99	FALSE
6	GTEx	Artery Aorta	SRRT	0.11	0.09	enet	20	0.09	1.4e-05	8.10	6.1	1.4e-09	0.00	0.01	0.98	FALSE
7	GTEx	Artery Tibial	ACHE	0.10	0.09	lasso	5	0.08	9.2e-07	8.10	8.1	5.3e-16	0.05	0.00	1.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	UFSP1	0.42	0.03	enet	7	0.05	1.9e-02	-6.24	-6.2	7.6e-10	-0.03	0.44	0.03	FALSE
9	GTEx	Breast Mammary Tissue	AP1S1	0.18	0.14	lasso	4	0.12	1.5e-06	-4.24	-5.8	6.4e-09	-0.01	0.82	0.05	FALSE
10	GTEx	Breast Mammary Tissue (Female)	PRKRIP1	0.14	-0.01	lasso	4	0.00	3.4e-01	-5.03	6.6	4.1e-11	0.05	0.03	0.06	TRUE
11	GTEx	Breast Mammary Tissue (Female)	ATP5J2	0.13	0.04	enet	10	0.10	5.5e-04	-7.61	-8.7	3.3e-18	-0.01	0.06	0.20	TRUE
12	GTEx	Cells EBV-transformed lymphocytes	RP11-163E9.2	0.25	0.23	enet	9	0.23	3.4e-08	4.80	-5.1	3.1e-07	-0.01	0.52	0.06	FALSE
13	GTEx	Cells Transformed fibroblasts	CPSF4	0.08	0.03	lasso	4	0.03	1.8e-03	7.43	7.6	2.7e-14	0.24	0.34	0.19	FALSE
14	GTEx	Cells Transformed fibroblasts	POLR2J3	0.32	0.08	lasso	7	0.11	8.6e-09	4.02	5.4	7.0e-08	0.03	0.96	0.00	FALSE
15	GTEx	Cells Transformed fibroblasts	RP11-514P8.8	0.31	0.12	lasso	7	0.14	1.0e-10	4.02	5.2	2.6e-07	0.00	1.00	0.00	TRUE
16	GTEx	Colon Sigmoid	CLDN15	0.29	0.00	lasso	4	0.00	4.5e-01	-6.19	-5.4	5.2e-08	-0.05	0.39	0.03	TRUE
17	GTEx	Esophagus Mucosa	ACHE	0.08	0.03	lasso	9	0.03	2.2e-03	5.48	7.2	5.1e-13	0.04	0.02	0.93	FALSE
18	GTEx	Esophagus Mucosa	GS1-259H13.2	0.07	0.07	lasso	3	0.05	1.7e-04	7.53	-7.7	1.2e-14	-0.24	0.46	0.34	TRUE
19	GTEx	Heart Atrial Appendage	ACHE	0.19	0.19	lasso	2	0.18	2.6e-08	7.61	7.6	2.9e-14	0.04	0.01	0.99	FALSE
20	GTEx	Heart Atrial Appendage	SRRT	0.14	0.01	enet	10	0.02	4.5e-02	7.61	8.2	3.7e-16	0.03	0.01	0.88	FALSE
21	GTEx	Heart Left Ventricle	CLDN15	0.22	0.02	lasso	7	0.03	1.3e-02	-4.54	-5.8	5.1e-09	0.02	0.98	0.00	TRUE
22	GTEx	Lung	ZKSCAN5	0.09	0.05	lasso	2	0.03	2.7e-03	7.43	-7.0	2.2e-12	-0.22	0.37	0.16	FALSE
23	GTEx	Lung	GS1-259H13.2	0.09	0.07	lasso	4	0.05	8.4e-05	7.53	-7.5	8.4e-14	-0.25	0.79	0.06	FALSE
24	GTEx	Muscle Skeletal	TRIP6	0.08	0.07	lasso	4	0.07	5.3e-07	7.04	6.4	1.6e-10	0.02	0.39	0.57	FALSE
25	GTEx	Muscle Skeletal	POLR2J3	0.35	0.12	enet	31	0.16	5.6e-16	4.02	5.3	9.0e-08	0.00	1.00	0.00	TRUE
26	GTEx	Nerve Tibial	ACHE	0.28	0.23	lasso	7	0.22	6.1e-16	7.61	7.4	1.1e-13	0.04	0.01	0.99	FALSE
27	GTEx	Nerve Tibial	SRRT	0.13	0.12	lasso	4	0.11	3.7e-08	7.43	7.5	5.2e-14	0.04	0.01	0.99	FALSE
28	GTEx	Nerve Tibial	ZKSCAN5	0.12	0.04	lasso	4	0.02	1.4e-02	3.80	-5.9	3.7e-09	-0.09	0.09	0.04	TRUE
29	GTEx	Nerve Tibial	GS1-259H13.2	0.15	0.10	lasso	4	0.09	3.4e-07	7.53	-7.5	8.4e-14	-0.24	1.00	0.00	FALSE
30	GTEx	Prostate	RP11-163E9.2	0.33	-0.01	lasso	10	0.00	2.5e-01	4.84	-5.4	5.4e-08	-0.04	0.03	0.25	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	TRIP6	0.11	0.02	lasso	6	0.01	1.3e-01	-3.09	5.4	8.5e-08	0.01	0.08	0.27	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	CLDN15	0.33	0.28	lasso	6	0.30	1.1e-16	-4.55	-5.5	5.1e-08	0.03	1.00	0.00	FALSE
33	GTEx	Skin Sun Exposed Lower leg	ACHE	0.07	0.10	lasso	1	0.09	3.5e-08	7.61	7.6	2.8e-14	0.04	0.04	0.96	FALSE
34	GTEx	Skin Sun Exposed Lower leg	POLR2J3	0.17	0.06	enet	15	0.08	5.1e-07	4.02	5.8	5.6e-09	-0.03	0.62	0.02	FALSE
35	GTEx	Skin Sun Exposed Lower leg	RASA4B	0.12	0.00	enet	20	0.04	2.2e-04	4.19	5.6	2.7e-08	0.02	0.03	0.05	TRUE
36	GTEx	Skin Sun Exposed Lower leg	RP11-514P8.8	0.17	0.08	enet	14	0.11	2.2e-09	4.02	5.8	6.8e-09	-0.02	0.92	0.00	TRUE
37	GTEx	Spleen	GIGYF1	0.22	0.00	enet	19	0.10	1.3e-03	-5.19	-5.7	1.3e-08	-0.38	0.13	0.09	FALSE
38	GTEx	Testis	ATP5J2	0.21	0.13	lasso	7	0.19	7.5e-09	3.74	-5.9	3.9e-09	-0.04	0.62	0.36	TRUE
39	GTEx	Thyroid	ACHE	0.19	0.10	enet	33	0.14	1.5e-10	8.10	9.1	1.5e-19	0.00	0.01	0.99	FALSE
40	GTEx	Whole Blood	ORAI2	0.13	0.13	enet	7	0.12	2.1e-11	4.84	-5.3	1.4e-07	-0.02	0.96	0.04	FALSE
41	METSIM	Adipose	ARPC1A	0.02	0.02	blup	308	0.02	1.6e-03	3.34	5.4	6.3e-08	0.00	0.16	0.73	TRUE
42	METSIM	Adipose	GS1-259H13.2	0.04	0.03	lasso	3	0.02	1.4e-03	7.52	-7.5	5.0e-14	-0.25	0.56	0.35	FALSE
43	METSIM	Adipose	MBLAC1	0.04	0.00	bslmm	284	0.01	1.8e-02	-0.17	5.8	5.8e-09	0.06	0.05	0.04	TRUE
44	METSIM	Adipose	PRKRIP1	0.12	0.00	blup	272	0.08	1.1e-11	2.88	6.2	7.4e-10	-0.01	0.81	0.17	FALSE
45	NTR	Blood	ORAI2	0.05	0.03	bslmm	256	0.03	2.0e-11	4.83	-6.2	6.8e-10	-0.01	0.94	0.06	TRUE
46	ROSMAP	Brain Pre-frontal Cortex	SRRT	0.05	0.02	bslmm	331	0.02	1.1e-03	8.10	9.5	1.7e-21	0.12	0.01	0.98	TRUE
47	ROSMAP	Brain Pre-frontal Cortex	ZKSCAN1	0.05	0.01	blup	265	0.03	6.1e-05	-2.46	-5.2	2.1e-07	-0.31	0.30	0.05	TRUE
48	ROSMAP	Brain Pre-frontal Cortex	SLC12A9	0.07	0.05	lasso	4	0.07	7.6e-10	-2.92	5.3	1.3e-07	-0.01	0.88	0.12	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	GS1-259H13.2	0.07	0.05	bslmm	305	0.06	6.9e-08	7.79	-7.1	1.2e-12	-0.17	0.63	0.37	TRUE
50	YFS	Blood	ORAI2	0.17	0.13	lasso	13	0.18	4.2e-56	4.83	-5.4	6.3e-08	-0.03	0.94	0.06	FALSE
51	YFS	Blood	PRKRIP1	0.11	0.09	enet	25	0.10	1.2e-30	4.84	5.2	2.5e-07	0.00	0.94	0.06	FALSE
52	YFS	Blood	TRIP6	0.08	0.10	lasso	6	0.11	6.7e-35	7.61	-7.2	8.0e-13	-0.06	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CUX1	0.10	0.03	blup	114	0.02	1.5e-02	2.99	-5.7	1.2e-08	0.05	0.22	0.05	TRUE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PILRA	0.05	0.01	blup	32	0.02	5.5e-03	-3.36	-5.2	1.7e-07	-0.33	0.02	0.58	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACHE	0.03	0.01	blup	56	0.01	1.8e-03	7.23	8.4	3.8e-17	0.05	0.01	0.76	FALSE
56	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	UFSP1	0.09	0.03	blup	53	0.05	1.2e-03	6.54	-9.1	1.1e-19	-0.03	0.02	0.59	FALSE
57	The Cancer Genome Atlas	Glioblastoma Multiforme	EPHB4	0.16	0.11	enet	7	0.07	3.8e-03	8.10	-7.6	2.4e-14	-0.06	0.00	0.91	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	AP1S1	0.07	0.02	enet	12	0.06	1.0e-07	-4.21	-5.2	1.6e-07	0.00	0.34	0.65	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZKSCAN5	0.03	0.04	lasso	2	0.03	1.0e-04	8.48	8.5	2.3e-17	0.17	0.01	0.99	TRUE
60	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C7orf52	0.23	0.10	blup	54	0.12	7.0e-06	-4.21	6.6	3.2e-11	0.01	0.28	0.63	TRUE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	FIS1	0.03	0.02	blup	42	0.02	1.8e-03	-4.54	5.2	2.3e-07	-0.02	0.01	0.49	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZKSCAN5	0.03	0.03	enet	8	0.03	5.4e-04	8.53	7.0	2.5e-12	0.16	0.01	0.84	TRUE
63	The Cancer Genome Atlas	Thyroid Carcinoma	ACHE	0.04	0.04	lasso	2	0.03	3.0e-04	7.43	7.5	8.6e-14	0.04	0.01	0.98	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	C7orf52	0.09	0.08	enet	16	0.12	1.8e-11	-6.57	5.7	1.2e-08	0.01	0.70	0.30	FALSE