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chr20:59,834,594-62,912,463

Best TWAS P=1.42e-23 · Best GWAS P=2.52e-18 conditioned to 0.321

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ARFRP1	0.07	0.07	lasso	3	0.06	5.3e-08	-5.4	5.4	5.9e-08	-0.08	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DIDO1	0.14	0.08	bslmm	503	0.09	7.3e-11	7.9	-6.7	2.2e-11	-0.06	0.11	0.89	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LAMA5	0.06	0.01	bslmm	495	0.01	6.2e-03	-4.9	-7.1	1.3e-12	0.48	0.21	0.31	FALSE
4	CommonMind	Brain Pre-frontal Cortex	NTSR1	0.09	0.00	enet	16	0.03	2.4e-04	1.4	-5.6	1.8e-08	0.09	0.08	0.12	TRUE
5	CommonMind	Brain Pre-frontal Cortex	STMN3	0.07	0.02	lasso	4	0.05	2.8e-06	-3.7	-6.0	1.8e-09	0.06	0.14	0.86	FALSE
6	GTEx	Adipose Subcutaneous	OGFR	0.28	0.13	lasso	4	0.12	2.2e-10	5.0	-5.2	2.5e-07	0.06	1.00	0.00	FALSE
7	GTEx	Adipose Subcutaneous	DIDO1	0.15	0.09	lasso	6	0.12	4.1e-10	5.1	-5.2	1.5e-07	-0.01	0.96	0.04	FALSE
8	GTEx	Adipose Subcutaneous	CABLES2	0.17	0.11	enet	11	0.14	2.3e-11	7.8	-8.2	3.2e-16	0.53	0.65	0.35	FALSE
9	GTEx	Artery Aorta	CABLES2	0.26	0.09	enet	28	0.16	3.6e-09	8.0	-7.0	3.5e-12	0.71	0.29	0.71	FALSE
10	GTEx	Artery Tibial	MTG2	0.37	0.12	enet	45	0.12	1.9e-09	4.6	-5.9	2.9e-09	0.21	1.00	0.00	FALSE
11	GTEx	Artery Tibial	LAMA5	0.12	0.05	enet	15	0.04	7.4e-04	-7.3	-5.6	1.7e-08	0.51	0.57	0.07	FALSE
12	GTEx	Artery Tibial	CABLES2	0.21	0.18	enet	16	0.20	8.3e-16	-8.6	-10.0	1.4e-23	0.83	0.00	1.00	TRUE
13	GTEx	Artery Tibial	RP11-157P1.4	0.15	0.05	lasso	5	0.09	3.4e-07	-8.6	-8.5	1.9e-17	0.70	0.02	0.98	FALSE
14	GTEx	Artery Tibial	RP11-157P1.5	0.15	0.06	enet	3	0.03	2.2e-03	-7.3	-7.5	9.4e-14	0.71	0.62	0.18	FALSE
15	GTEx	Breast Mammary Tissue	GID8	0.19	0.00	enet	14	0.02	3.5e-02	8.3	-7.8	4.9e-15	0.00	0.02	0.82	TRUE
16	GTEx	Breast Mammary Tissue	CABLES2	0.18	0.08	lasso	3	0.04	2.7e-03	8.1	-8.2	2.8e-16	0.57	0.29	0.67	FALSE
17	GTEx	Breast Mammary Tissue (Female)	CABLES2	0.28	0.00	enet	8	0.00	2.5e-01	8.2	-9.0	3.1e-19	0.56	0.07	0.20	FALSE
18	GTEx	Cells Transformed fibroblasts	LAMA5	0.14	0.12	lasso	4	0.12	5.0e-09	-8.2	7.9	2.9e-15	-0.66	0.21	0.79	FALSE
19	GTEx	Cells Transformed fibroblasts	RP11-157P1.5	0.15	0.12	enet	15	0.10	7.3e-08	-8.2	7.1	1.7e-12	-0.62	0.19	0.81	FALSE
20	GTEx	Colon Sigmoid	CABLES2	0.29	0.08	lasso	11	0.08	6.3e-04	8.2	-8.6	6.6e-18	0.78	0.04	0.92	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	CABLES2	0.25	0.10	lasso	4	0.15	4.8e-06	-8.7	-9.9	3.6e-23	0.89	0.01	0.99	FALSE
22	GTEx	Esophagus Mucosa	LAMA5	0.18	0.10	lasso	4	0.10	2.9e-07	-7.6	8.5	2.4e-17	-0.76	0.02	0.98	FALSE
23	GTEx	Esophagus Mucosa	CABLES2	0.24	0.13	lasso	7	0.11	9.1e-08	7.8	-7.1	1.1e-12	0.49	0.32	0.68	FALSE
24	GTEx	Esophagus Muscularis	DIDO1	0.13	0.05	lasso	6	0.05	4.3e-04	3.5	-6.1	1.1e-09	-0.04	0.18	0.79	TRUE
25	GTEx	Esophagus Muscularis	CABLES2	0.28	0.23	lasso	6	0.35	5.4e-22	-8.7	-9.8	9.3e-23	0.86	0.00	1.00	FALSE
26	GTEx	Heart Atrial Appendage	CABLES2	0.17	0.02	lasso	6	0.05	3.7e-03	-8.5	-9.8	1.2e-22	0.83	0.01	0.96	FALSE
27	GTEx	Heart Atrial Appendage	RP11-157P1.5	0.29	0.22	lasso	9	0.21	6.1e-10	-7.8	7.7	1.2e-14	-0.78	0.01	0.99	FALSE
28	GTEx	Heart Left Ventricle	CABLES2	0.19	0.20	lasso	5	0.18	3.8e-10	8.2	-9.2	4.8e-20	0.76	0.06	0.94	FALSE
29	GTEx	Heart Left Ventricle	RP11-157P1.5	0.21	0.08	lasso	7	0.14	6.5e-08	-7.4	5.8	4.8e-09	-0.68	0.10	0.90	FALSE
30	GTEx	Liver	LAMA5	0.35	0.11	lasso	5	0.08	2.4e-03	-7.6	-8.5	2.1e-17	0.78	0.04	0.89	FALSE
31	GTEx	Liver	RP11-157P1.5	0.39	0.18	lasso	9	0.27	3.1e-08	-7.8	8.5	2.5e-17	-0.82	0.02	0.98	FALSE
32	GTEx	Lung	CABLES2	0.29	0.16	enet	22	0.19	1.1e-14	7.7	-8.2	1.9e-16	0.43	0.32	0.68	FALSE
33	GTEx	Muscle Skeletal	CABLES2	0.10	0.02	lasso	4	0.04	2.1e-04	-7.3	-8.3	1.4e-16	0.76	0.22	0.68	FALSE
34	GTEx	Muscle Skeletal	RP11-157P1.5	0.14	0.02	enet	14	0.02	2.8e-03	-7.3	7.2	8.4e-13	-0.76	0.02	0.98	FALSE
35	GTEx	Nerve Tibial	DIDO1	0.11	0.06	lasso	3	0.07	6.2e-06	6.7	-7.4	1.4e-13	-0.02	0.15	0.84	FALSE
36	GTEx	Nerve Tibial	CABLES2	0.30	0.15	enet	52	0.22	2.4e-15	8.2	-7.5	8.0e-14	0.68	0.30	0.70	FALSE
37	GTEx	Ovary	OGFR	0.50	0.28	enet	51	0.32	1.2e-08	5.0	-5.4	5.5e-08	0.07	0.25	0.04	FALSE
38	GTEx	Pituitary	OGFR	0.26	0.13	lasso	8	0.11	1.3e-03	5.0	-5.6	2.3e-08	0.03	0.12	0.07	TRUE
39	GTEx	Prostate	CABLES2	0.31	0.10	lasso	8	0.14	2.1e-04	8.2	-7.5	6.3e-14	0.63	0.10	0.23	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	CABLES2	0.16	0.07	lasso	7	0.10	2.5e-06	8.2	-9.3	1.2e-20	0.70	0.31	0.63	FALSE
41	GTEx	Skin Sun Exposed Lower leg	CABLES2	0.18	0.17	enet	13	0.16	3.4e-13	7.8	-9.3	2.0e-20	0.68	0.49	0.51	FALSE
42	GTEx	Small Intestine Terminal Ileum	OGFR	0.37	0.26	lasso	4	0.18	8.1e-05	5.0	-5.2	2.2e-07	0.03	0.10	0.06	FALSE
43	GTEx	Testis	MRGBP	0.28	0.14	lasso	10	0.23	1.6e-10	4.8	-5.2	1.7e-07	0.00	0.66	0.02	FALSE
44	GTEx	Testis	TAF4	0.22	0.05	enet	6	0.06	1.4e-03	-5.8	-5.9	4.8e-09	0.02	0.28	0.03	TRUE
45	GTEx	Thyroid	DIDO1	0.13	0.11	lasso	4	0.13	6.7e-10	3.5	-6.0	2.0e-09	-0.03	0.52	0.48	FALSE
46	GTEx	Vagina	CABLES2	0.49	0.04	lasso	6	0.02	1.4e-01	-8.2	-8.4	4.7e-17	0.65	0.04	0.45	FALSE
47	METSIM	Adipose	CABLES2	0.16	0.14	lasso	8	0.15	8.6e-22	8.2	-8.0	9.9e-16	0.52	0.20	0.80	FALSE
48	METSIM	Adipose	HAR1A	0.07	0.00	bslmm	503	0.02	1.3e-03	-1.1	-5.3	1.2e-07	-0.12	0.07	0.02	FALSE
49	YFS	Blood	CABLES2	0.03	0.03	lasso	6	0.02	2.0e-08	-7.4	-8.8	1.2e-18	0.63	0.75	0.25	FALSE
50	YFS	Blood	LIME1	0.12	0.19	enet	15	0.19	5.3e-59	-6.4	-5.9	3.2e-09	0.06	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GATA5	0.04	0.01	blup	33	0.02	3.1e-03	3.1	-5.3	8.9e-08	0.29	0.01	0.57	FALSE
52	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LIME1	0.08	0.07	lasso	4	0.06	2.0e-04	-6.7	6.4	1.7e-10	-0.08	0.00	0.99	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	CABLES2	0.09	0.04	enet	10	0.07	4.5e-08	8.2	-6.3	3.0e-10	0.31	0.19	0.81	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	TNFRSF6B	0.02	0.01	enet	7	0.01	6.9e-03	-4.6	-5.3	9.2e-08	0.08	0.05	0.67	FALSE
55	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RTEL1	0.05	0.04	blup	56	0.03	4.2e-03	-6.1	-6.5	6.4e-11	0.07	0.02	0.55	TRUE
56	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TNFRSF6B	0.05	0.02	blup	44	0.03	2.9e-03	-6.0	-5.3	1.4e-07	0.06	0.02	0.41	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARFRP1	0.03	0.02	lasso	2	0.02	1.2e-03	-5.4	5.4	5.4e-08	-0.07	0.03	0.87	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	LIME1	0.04	0.05	blup	47	0.05	9.0e-06	-6.5	-6.3	2.7e-10	0.07	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC2A4RG	0.05	0.01	blup	48	0.02	2.0e-03	-5.9	6.2	7.7e-10	-0.06	0.01	0.95	FALSE
60	The Cancer Genome Atlas	Soft Tissue Sarcoma	C20orf201	0.08	0.05	enet	10	0.06	2.2e-04	5.0	5.4	7.0e-08	0.07	0.00	0.88	TRUE
61	The Cancer Genome Atlas	Soft Tissue Sarcoma	DIDO1	0.15	0.00	blup	95	0.03	6.5e-03	4.6	-6.2	4.6e-10	0.00	0.02	0.05	FALSE
62	The Cancer Genome Atlas	Skin Cutaneous Melanoma	STMN3	0.24	0.03	enet	6	0.10	1.5e-03	-4.5	5.2	1.5e-07	-0.02	0.03	0.11	FALSE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LIME1	0.10	0.02	blup	47	0.04	1.5e-02	-5.9	-6.1	1.3e-09	0.07	0.02	0.43	FALSE
64	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS21	0.15	0.01	blup	59	0.02	4.9e-02	-6.5	7.4	1.3e-13	-0.80	0.02	0.26	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	COL9A3	0.05	0.01	blup	69	0.03	6.8e-04	4.7	-5.6	2.2e-08	-0.07	0.04	0.05	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	LIME1	0.05	0.03	blup	47	0.04	3.9e-05	-4.5	-5.4	8.1e-08	0.07	0.14	0.82	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	MYT1	0.10	0.00	blup	91	0.04	1.9e-04	-4.0	5.2	1.8e-07	-0.06	0.03	0.19	TRUE