Hub : Genes

MRGBP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.2630 0.0800 0.00330 0.124 NA 0.130 NA 0.102 6.7e-07 NA 3.5e-07 NA 6.5e-06
2 GTEx Breast Mammary Tissue (Male) 0.1633 0.1310 0.16000 0.152 NA 0.017 NA 0.109 2.3e-04 NA 1.3e-01 NA 1.8e-03
3 GTEx Breast Mammary Tissue (Female) 0.0809 0.0948 0.25000 0.003 NA -0.009 NA -0.009 2.6e-01 NA 7.5e-01 NA 7.6e-01
4 GTEx Testis 0.2770 0.0780 0.00031 0.136 NA 0.216 NA 0.229 1.3e-06 NA 6.0e-10 NA 1.6e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.2 0.6 0.8 -0.0 0.0 0.5
Bipolar Disorder or Schizophrenia 0.3 0.8 2.2 1.5 0.4 0.0 0.9
Depressed Affect (Nagel 2018) 0.2 0.4 1.1 -0.4 0.2 1.1 -0.7
Depression (Nagel 2018) 0.1 0.2 0.9 0.0 -0.0 0.0 -0.9
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.0 -1.0 0.5 0.8 0.1
Neuroticism (Nagel 2018) 0.2 0.4 1.0 -0.7 0.1 0.2 -1.0
Schizophrenia (2018) 0.2 0.5 1.0 1.0 0.6 0.0 0.7
Schizophrenia vs Biploar Disorder 0.8 1.0 2.3 -1.3 0.0 0.0 -1.5
Worry (Nagel 2018) 0.2 0.3 0.9 -0.3 -0.5 0.2 -1.0
Alzheimer’s Disease (in mother) 0.9 1.1 1.9 0.6 1.2 1.4 0.7
Alzheimer’s Disease (in father) 0.9 0.9 1.4 1.1 1.2 -0.6 0.9
Alzheimer’s Disease (including proxy) 0.4 0.6 1.0 0.8 1.0 0.4 0.8
Crohns Disease (2017) 0.1 0.2 0.4 0.6 -0.6 -0.1 -0.2
Irritable Bowel Disease (IBD) 0.2 0.4 1.0 1.0 0.1 -0.8 -0.1
Ulcerative Colitis (UC) 0.3 0.6 1.0 1.0 0.9 -0.4 0.4
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.4 2.7 6.1 2.5 0.7 -1.6 -1.3
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.2 -0.2 1.1 -0.6 -0.0
Breast Cancer 0.9 2.2 5.7 0.1 -1.7 -0.3 -2.4
Ovarian Cancer 0.5 0.6 1.0 0.7 -1.0 0.1 -1.0
Prostate Cancer 0.5 0.8 2.5 -0.5 -0.2 1.6 0.5
Age at First Birth 2.2 3.2 7.0 -1.6 -2.7 0.5 -1.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.3 3.1 -0.8 -0.1 -1.2 -1.8
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.1 0.2 0.9 -1.0 0.0 0.0 -0.1
Mean Putamen Volume 0.2 0.2 0.4 -0.7 -0.4 0.4 0.3
Fasting Glucose 0.3 0.3 0.9 -0.3 -0.0 0.9 0.6
HbA1C 0.4 0.4 1.3 0.7 -0.0 -1.1 -0.0
HDL Cholesterol 0.1 0.2 0.9 0.1 0.0 -0.1 1.0
LDL Cholesterol 0.2 0.4 0.7 -0.2 -0.8 0.8 0.3
Lupus 0.4 0.6 1.0 0.7 1.0 0.7 0.4
Neuroticism (2016) 2.3 3.4 9.8 -3.1 -0.9 -1.0 -1.4
Primary Biliary Cirrhosis 0.5 0.6 1.2 -0.8 0.7 -0.5 1.1
Rheumatoid Arthritis 0.0 0.1 0.2 -0.1 0.4 0.0 -0.2
Schizophrenia (2014) 0.2 0.4 1.6 1.3 0.0 0.0 0.3
Triglycerides 0.5 0.9 2.1 -0.4 -1.4 0.1 -1.1
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.0 -0.6 -0.4 0.0 -1.4
Ulcerative Colitis 0.3 0.4 1.2 -0.5 -1.1 0.0 -0.4
Blood Eosinophil Count 0.0 0.3 1.0 -1.0 0.4 0.5 -0.1
Blood Platelet Count 0.2 1.8 5.7 2.4 -0.2 1.2 0.1
Blood Red Count 0.0 0.1 0.2 -0.2 0.5 -0.4 0.4
Blood White Count 0.0 0.3 0.5 -0.7 -0.4 0.7 -0.3
Heel T-Score 0.1 0.8 2.6 1.6 -0.5 -0.3 -0.5
BMI 0.2 1.4 3.1 0.5 0.9 -1.8 -1.1
Height 0.8 16.2 27.4 -4.9 -3.7 -0.2 -5.2
Waist Hip Ratio (WHR) 0.8 3.7 6.7 -0.5 -2.1 -1.8 -2.6
Systolic Blood Pressure 0.3 1.5 4.0 0.1 2.0 0.1 1.5
Smoking Status 0.1 0.3 0.7 -0.1 0.4 0.9 0.4
Allergy or Eczema 0.2 0.5 1.2 -0.1 1.1 -0.8 -0.1
Cardiovascular Disease 0.1 0.2 0.5 0.1 0.7 -0.3 0.5
Hypothyroidism (self reported) 0.3 0.7 1.4 -1.1 -0.6 -0.4 -1.2
Respiratory disease 0.3 0.7 1.1 0.4 0.9 0.8 1.0
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.1 0.5 -0.8 -1.0 -0.2
Lung FEV1/FVC ratio 0.1 0.7 1.3 0.5 -0.5 -1.1 -1.0
Lung FVC 0.0 0.2 0.5 -0.5 -0.3 0.3 0.7
Neuroticism 0.7 1.7 3.2 -1.7 -0.2 -0.9 -1.8
Chronotype (morning person) 0.2 0.4 1.2 -1.1 -0.6 -0.1 -0.1
Hair Pigment 0.0 0.3 0.6 0.2 0.5 0.4 0.8
Tanning 0.3 3.8 10.7 -0.2 -0.6 3.3 2.0
Hand grip strength (left) 0.2 0.7 1.7 -1.3 0.4 0.8 0.4
Number of treatments/medications taken 0.4 0.8 1.4 -1.2 -1.2 0.6 -0.2
Average weekly spirits intake 0.7 0.9 2.2 0.3 0.7 1.5 0.9
Sensitivity / hurt feelings 0.5 0.9 2.0 -1.4 0.1 -0.6 -1.2
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.8 0.5 0.9 0.1 -0.4
Hearing difficulty/problems: Yes 2.3 3.5 6.1 -1.6 -1.5 -1.7 -2.5
Relative age of first facial hair 0.2 0.5 1.1 1.0 0.6 -0.6 0.4
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 3.5 -0.4 -1.2 -1.0 -1.9
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.9 -0.5 -1.4 0.8 -0.2
Ever had hysterectomy (womb removed) 0.1 0.1 0.4 -0.6 0.3 -0.2 0.1
Systolic blood pressure, automated reading 0.5 1.5 2.8 1.0 1.7 -0.4 1.5
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 2.8 -1.2 -1.7 0.7 -0.6
Angina 1.1 1.4 2.4 -1.6 -1.4 -0.4 -1.0
Medication for hormone replacement therapy 0.4 0.5 0.8 0.7 0.8 0.2 0.9
Vitamin and mineral supplements 0.9 1.2 2.4 -1.6 -0.5 -0.9 -1.1
Supplements: Zinc 1.2 1.3 1.8 1.4 1.3 0.8 1.0
Medication: Co-codamol 0.5 0.6 1.3 0.9 0.3 -1.1 -0.3
Medication: Metformin 3.9 5.5 13.8 -1.4 -1.3 -3.7 -2.1
Diabetes (father) 0.3 0.3 1.2 0.2 -0.2 -1.1 -0.2
Diabetes (mother) 0.3 0.4 1.1 0.3 0.1 1.1 -0.5
Severe depression (siblings) 1.6 1.7 4.0 -2.0 -0.7 -0.9 -1.3
Pack years adult smoking proportion 0.1 0.2 0.4 0.2 0.5 -0.7 0.3
Impedance of leg (right) 0.2 1.1 2.0 -0.3 -1.2 1.4 0.9
Leg fat-free mass (left) 0.5 2.7 5.9 -1.6 -0.1 -1.5 -2.4
Trunk fat percentage 0.2 1.0 2.0 -0.8 -1.1 -0.1 -1.4
Hand grip strength (right) 0.5 1.4 4.1 -2.0 0.5 1.0 0.2
Townsend deprivation index at recruitment 0.3 0.4 1.0 0.8 1.0 -0.1 0.0
Current tobacco smoking 0.1 0.1 0.2 0.4 -0.0 0.4 -0.5
Average weekly fortified wine intake 0.1 0.1 0.2 0.4 0.4 -0.1 -0.1
Maternal smoking around birth 0.6 0.8 2.1 -0.1 0.8 0.7 1.4
Fed-up feelings 0.1 0.3 0.5 -0.1 0.7 0.7 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.9 -0.5 -0.7 0.1 -1.4
Relative age voice broke 0.2 0.4 0.7 0.8 -0.3 -0.4 -0.8
Taking other prescription medications 0.3 0.4 0.8 -0.3 0.3 0.8 0.9
Age when periods started (menarche) 1.6 3.8 6.6 1.6 2.6 2.0 1.4
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 3.5 0.8 0.8 0.6 1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 0.9 1.0 -0.8 -0.7 -0.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.2 -0.3 0.5 -1.5 -0.8
Qualifications: CSEs or equivalent 1.0 1.3 2.8 1.7 1.5 0.5 0.1
Serious illness, injury or assault to yourself 0.0 0.0 0.2 0.0 -0.0 -0.2 0.4
High blood pressure 0.3 0.8 2.6 -1.6 -0.5 -0.0 0.3
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.6 0.4 0.8 -0.1 -0.3
Multivitamins +/- minerals 0.4 0.5 1.2 1.1 0.2 0.5 0.7
Stomach or abdominal pain in last month 0.3 0.4 0.7 -0.8 -0.7 0.7 -0.2
Supplements: Glucosamine 0.2 0.2 0.6 -0.2 0.8 0.4 0.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.7 0.8 0.1 -0.8 -0.5
Medication: Atenolol 0.6 0.7 1.2 -0.5 -1.0 0.6 -1.1
Medication: Levothyroxine sodium 0.2 0.4 0.8 0.1 -0.6 0.9 -0.5
Sitting height 0.1 0.4 1.4 -0.1 -0.3 0.2 -1.2
Chronic bronchitis/emphysema (father) 1.1 1.3 3.3 1.8 1.1 -0.0 0.7
High blood pressure (mother) 0.0 0.0 0.1 0.1 0.4 0.1 0.1
Body mass index (BMI) 0.2 0.9 1.5 -0.8 0.3 -1.2 -1.2
Impedance of leg (left) 0.3 1.5 3.1 -0.1 -0.9 1.8 1.4
Leg predicted mass (left) 0.5 2.8 5.9 -1.6 -0.2 -1.6 -2.4
Trunk fat mass 0.3 1.4 3.4 -1.1 -0.7 -0.6 -1.9
Waist circumference 0.9 3.3 6.6 -1.1 -0.6 -2.2 -2.6
Number of incorrect matches in round 1.3 2.1 4.4 0.6 0.3 2.1 1.9
Past tobacco smoking 0.1 0.2 0.5 -0.7 -0.5 -0.3 -0.0
Alcohol usually taken with meals 0.8 1.3 2.7 -1.2 -1.6 -0.6 -0.9
Nervous feelings 0.4 0.7 1.5 0.0 -0.3 -1.1 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.3 -0.2 0.6 0.3 0.2
Hearing difficulty/problems with background noise 0.9 1.4 2.7 -1.0 -1.4 -0.5 -1.6
Hair/balding pattern: Pattern 2 0.2 0.3 1.0 -1.0 -0.4 -0.2 -0.2
Had menopause 0.2 0.2 0.3 0.4 -0.4 -0.6 -0.4
Had other major operations 0.5 0.6 2.4 0.1 0.3 1.5 0.1
Forced vital capacity (FVC) 0.0 0.1 0.2 -0.3 0.5 -0.0 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 3.8 1.9 0.1 -0.1 0.2
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.9 1.4 0.6 1.3 -0.0
Qualifications: None of the above 0.2 0.5 1.2 -1.1 -0.8 0.2 -0.2
Financial difficulties in last 2 years 0.9 1.2 1.7 -1.3 1.1 1.3 0.3
Mouth/teeth dental problems 0.1 0.2 0.3 -0.3 -0.5 0.5 0.3
Heart attack 1.4 1.8 3.9 -0.7 -1.5 2.0 0.5
Allergy 0.1 0.3 0.8 -0.5 -0.9 0.1 -0.5
Pain all over the body in last month 0.3 0.3 0.6 -0.3 0.6 -0.8 -0.3
Diabetes (self-reported) 0.2 0.2 0.6 -0.3 -0.8 -0.5 -0.1
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.3 1.1 0.2 -0.8 -0.8
Medication: Ramipril 0.1 0.1 0.3 -0.1 -0.5 0.2 -0.1
Medication: Simvastatin 0.6 1.0 2.0 0.1 0.2 1.3 1.4
Fluid intelligence score 0.4 0.8 1.4 -0.0 1.2 0.9 1.0
Illnesses of siblings 1.1 1.5 2.6 1.6 1.4 1.0 0.6
Neuroticism score 0.3 0.6 1.3 -1.1 0.6 0.1 -0.9
Weight 0.5 2.4 5.3 -1.5 -0.5 -1.2 -2.3
Impedance of arm (right) 0.6 2.7 9.2 -0.7 -3.0 0.9 -0.7
Arm fat percentage (right) 0.5 1.8 3.1 -1.2 -1.5 -0.7 -1.8
Trunk fat-free mass 0.4 2.2 3.8 -1.5 0.7 -1.4 -1.9
Hip circumference 0.8 3.3 6.3 -1.7 -0.7 -1.9 -2.5
Time employed in main current job 1.8 2.1 4.9 -1.6 -2.2 0.1 -0.9
Alcohol intake versus 10 years previously 0.5 0.8 1.2 -0.8 -0.2 1.1 1.1
Father’s age at death 1.7 2.3 8.6 2.9 -0.2 0.6 0.3
Worrier / anxious feelings 0.3 0.5 1.0 -0.8 0.4 -1.0 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.4 -0.3 1.5 -0.5 0.2
Falls in the last year 0.6 0.8 2.9 1.7 -0.2 0.2 -0.2
Hair/balding pattern: Pattern 3 0.1 0.2 0.5 -0.1 0.7 -0.5 -0.2
Number of live births 2.4 3.4 4.3 2.1 1.9 1.1 2.1
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.9 -0.7 0.0 -1.3 -1.4
Pulse rate 0.8 1.3 3.8 1.9 1.1 0.1 -0.4
Happiness 0.5 0.6 2.0 -0.1 1.4 0.1 0.7
Noisy workplace 0.2 0.3 0.7 0.1 -0.1 0.6 0.8
Qualifications: A levels/AS levels or equivalent 0.4 1.0 3.1 0.4 0.0 -1.8 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.7 0.2 -0.8 -1.0 -1.3
Mouth/teeth dental problems: Dentures 0.8 1.3 3.0 -1.1 -1.7 0.5 -1.0
Asthma 1.9 3.8 5.1 2.2 2.3 0.9 2.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.4 -0.2 -0.1 0.3 -0.7
Medication: Cholesterol lowering 1.0 1.5 3.2 -0.3 -0.2 1.7 1.8
Depression (self-reported) 0.5 0.6 1.6 0.5 0.3 1.3 0.7
Medication: Lansoprazole 0.9 1.1 2.4 -1.6 -1.3 -0.3 -0.4
Prospective memory result 0.3 0.4 1.0 -1.0 -0.3 -0.7 -0.4
Lung cancer (father) 0.5 0.5 1.0 -0.9 -1.0 0.4 -0.4
Illnesses of mother 0.3 0.3 0.7 0.1 -0.8 -0.5 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 2.5 -1.6 -0.3 -1.0 -0.9
Pulse wave Arterial Stiffness index 0.3 0.3 1.1 -0.3 -1.1 0.3 -0.2
Impedance of arm (left) 0.5 2.2 6.7 -0.0 -2.6 1.5 -0.2
Arm fat mass (right) 0.5 2.1 4.0 -1.4 -0.8 -1.3 -2.0
Trunk predicted mass 0.4 2.1 3.8 -1.5 0.7 -1.4 -1.9
Standing height 0.3 3.2 6.6 -2.1 -1.4 -0.1 -2.6
Length of working week for main job 0.9 1.0 3.8 0.5 -0.1 1.9 0.3
Exposure to tobacco smoke at home 0.3 0.3 0.9 0.0 0.2 -0.6 -0.9
Breastfed as a baby 0.4 0.5 1.4 0.3 1.2 -0.6 0.1
Tense / ‘highly strung’ 0.6 1.0 3.4 -0.6 -0.2 1.8 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.0 -0.3 -0.2 1.0 0.3
Hair/balding pattern: Pattern 4 0.4 1.0 2.9 0.9 -0.3 1.7 0.4
Birth weight of first child 0.2 0.3 0.5 -0.7 -0.3 0.7 -0.3
Peak expiratory flow (PEF) 0.6 1.3 3.2 -0.1 0.7 -1.8 -1.2
Pulse wave reflection index 0.4 0.5 1.7 0.4 0.4 0.4 1.3
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.7 0.5 1.2 1.6 1.1
Loud music exposure frequency 0.9 1.0 1.9 -1.4 -1.2 0.3 -0.7
Qualifications: O levels/GCSEs or equivalent 1.1 1.8 4.9 -0.5 0.6 -2.2 -1.3
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.2 0.5 1.1 0.5 0.2
Blood clot in the leg (DVT) 0.3 0.4 1.2 -0.3 0.1 0.5 1.1
Medication: Paracetamol 0.8 1.3 2.0 0.5 -1.4 1.0 -1.3
Headache pain in last month 0.8 1.4 2.2 -1.2 -1.3 -0.5 -1.5
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 5.1 -0.4 -0.0 -2.0 -2.3
Glaucoma (self-reported) 1.6 1.9 3.6 0.9 0.8 1.5 1.9
Gout (self-reported) 0.3 0.4 1.4 -0.4 0.3 0.3 1.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 -0.4 -0.1 0.5 0.3
Medication: Amlodipine 0.3 0.4 1.0 0.5 1.0 -0.6 0.1
Medication: Ventolin 100micrograms inhaler 1.3 1.7 3.7 1.1 1.9 -0.8 1.1
Birth weight 0.2 0.5 1.5 -0.8 0.2 0.2 -1.2
Chronic bronchitis/emphysema (mother) 1.1 1.2 2.2 -1.1 -1.0 -1.5 -0.6
High blood pressure (siblings) 0.5 0.7 2.4 -0.1 -1.6 -0.3 -0.5
Forced vital capacity (FVC), Best measure 0.1 0.5 1.5 -1.2 -0.3 -0.2 -0.6
Body fat percentage 0.3 1.1 1.9 -1.1 -1.0 -0.3 -1.4
Leg fat percentage (right) 0.3 0.9 1.5 -1.2 -0.8 -0.3 -1.2
Arm fat-free mass (right) 0.2 1.2 2.4 -0.8 1.1 -0.7 -1.5
Exposure to tobacco smoke outside home 0.5 0.6 1.5 -0.4 0.3 1.2 0.8
Comparative body size at age 10 0.4 1.1 2.6 -1.6 0.4 -1.2 -0.5
Number of full brothers 0.7 0.9 1.6 -0.1 1.3 1.0 1.0
Worry too long after embarrassment 1.3 2.1 3.7 -1.2 1.9 -1.8 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.1 -0.8 0.1 -0.8
Wheeze or whistling in the chest in last year 0.1 0.1 0.4 0.2 -0.0 0.6 -0.2
Number of children fathered 1.6 1.8 4.0 -1.0 -2.0 -1.3 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.9 -0.5 -0.1 0.9 -0.3
Age at first live birth 0.4 0.8 2.2 -0.1 0.8 -0.4 1.5
Pulse wave peak to peak time 0.2 0.3 0.9 0.2 0.9 -0.1 0.3
Health satisfaction 0.9 1.1 3.0 -1.7 -0.5 -0.9 -0.7
Shortness of breath walking on level ground 1.9 2.3 4.4 -1.2 -1.6 -0.8 -2.1
Qualifications: College or University degree 0.2 0.5 0.9 -0.6 -0.6 -1.0 -0.4
Eye problems/disorders: None of the above 0.4 0.4 0.6 0.8 -0.7 -0.4 -0.6
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.1 -0.3 -0.9 1.0 -0.3
Emphysema/chronic bronchitis 0.5 0.6 1.2 -0.6 -0.0 1.1 0.9
Medication for pain relief, constipation, heartburn 0.9 1.5 3.5 0.5 1.3 -1.9 0.5
Neck or shoulder pain in last month 0.2 0.3 1.0 0.4 0.1 1.0 -0.1
Medication: Blood pressure 0.6 1.1 3.2 -0.1 0.2 1.1 1.8
Angina (self-reported) 1.1 1.4 2.4 -1.5 -1.5 -0.3 -1.0
Migraine (self-reported) 0.0 0.0 0.0 -0.1 -0.2 -0.0 0.0
Medication: Ibuprofen 0.1 0.1 0.4 0.1 -0.1 -0.1 -0.7
Medication: Allopurinol 0.5 0.6 1.2 -0.8 -0.2 0.8 1.1
Medication: Omeprazole 0.1 0.1 0.3 -0.2 -0.4 0.3 -0.6
Medication: Seretide 50 evohaler 0.6 0.7 1.4 0.9 0.7 -1.2 -0.3
Mean time to correctly identify matches 1.1 2.1 5.5 2.3 -0.2 -1.0 -1.5
Heart disease (mother) 0.6 0.7 1.6 -0.6 0.5 0.9 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 0.2 0.3 -0.4 0.4
Whole body fat mass 0.5 2.2 4.3 -1.5 -0.8 -1.2 -2.1
Leg fat mass (right) 0.4 1.7 3.2 -1.4 -0.7 -1.0 -1.8
Arm predicted mass (right) 0.2 1.2 1.8 -1.0 1.2 -0.8 -1.3
Pulse rate, automated reading 0.4 1.1 4.0 2.0 0.5 0.2 -0.5
Alcohol intake frequency. 0.6 1.4 2.3 -1.0 -1.5 -1.3 -0.9
Comparative height size at age 10 0.6 3.2 7.3 -2.7 -1.6 -0.0 -1.8
Number of full sisters 1.0 1.2 2.4 -1.4 -0.4 -0.4 -1.6
Suffer from ‘nerves’ 0.2 0.3 0.7 -0.4 -0.3 0.5 -0.9
Overall health rating 1.5 3.2 6.7 -0.6 -0.3 -2.4 -2.6
Chest pain or discomfort 1.0 1.4 5.2 0.2 -0.7 2.3 -0.1
Had major operations 0.5 0.5 1.0 -0.6 1.0 -0.2 0.9
Age at last live birth 0.9 1.3 3.2 0.8 1.1 -1.8 0.1
Family relationship satisfaction 0.6 0.8 1.0 -0.8 -0.6 -1.0 -1.0
Leg pain on walking 0.1 0.1 0.4 -0.6 0.3 0.2 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.5 0.3 -0.8 1.2 -0.3
Commuting to job workplace: Car/motor vehicle 1.9 2.2 3.5 1.3 1.9 1.4 1.3
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.9 -0.0 -1.1 -1.4 -1.3
Medication: Aspirin 0.5 0.7 1.4 -1.1 -0.5 1.2 0.2
Supplements: Vitamin C 2.3 2.7 4.3 1.9 0.1 1.7 2.1
Knee pain experienced in last month 0.5 0.8 1.3 -0.7 1.1 1.1 0.5
Hypertension (Self-reported) 0.2 0.6 1.9 -1.4 0.0 -0.2 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.6 -0.7 -0.5 0.3 -0.1
Illnesses of father: Heart disease 3.2 4.5 6.6 -2.1 -2.2 -1.4 -2.6
Illnesses of siblings: Diabetes 1.0 1.2 1.6 -1.0 -0.8 -1.3 -1.3
Smoking status: Previous 0.4 0.6 1.3 0.9 1.1 0.2 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 2.1 -1.5 -0.7 -0.1 -1.3
Whole body fat-free mass 0.4 2.5 4.8 -1.7 0.5 -1.5 -2.2
Leg fat-free mass (right) 0.4 2.3 4.9 -1.5 0.1 -1.5 -2.2
Arm fat percentage (left) 0.3 1.0 2.0 -0.9 -1.1 -0.5 -1.4
Average weekly red wine intake 0.0 0.0 0.1 0.2 0.2 0.2 0.2
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.9 0.8 -0.1 0.9 0.3
Mood swings 0.4 0.8 1.2 -0.4 1.1 1.1 0.8
Loneliness, isolation 0.5 0.7 1.8 0.3 1.3 -0.2 -0.9
Long-standing illness, disability or infirmity 2.0 3.0 4.4 -2.0 -0.8 -2.1 -1.7
Ever had bowel cancer screening 1.1 1.3 3.1 -0.6 0.2 1.8 1.3
Diabetes diagnosed by doctor 0.4 0.6 1.1 -0.5 -0.9 -1.1 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 3.1 -0.2 -1.4 -0.4 -1.8
Friendships satisfaction 0.7 0.9 2.7 -0.4 1.6 -0.8 -0.1
Qualifications: nursing, teaching 2.0 3.1 4.2 -2.0 -1.9 -1.5 -1.5
Commuting to job workplace: Walk 0.5 0.5 1.1 0.2 0.9 -1.0 -0.4
Eye problems/disorders: Cataract 0.5 0.6 1.8 0.6 1.3 0.3 0.3
Mouth/teeth dental problems: Mouth ulcers 1.3 2.0 6.2 0.0 1.3 -2.5 -0.2
Medication for cholesterol 1.1 1.6 2.6 1.3 1.1 1.1 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.3 1.1 -0.2 0.1 -0.7
Back pain experienced in last month 0.3 0.4 0.7 0.6 0.8 0.2 0.8
Mineral and other dietary supplements 0.8 1.0 3.9 -0.2 0.2 -2.0 -0.5
Breast cancer (self-reported) 1.0 1.1 2.6 -1.6 0.2 1.2 0.7
Asthma (self-reported) 1.7 3.3 5.1 2.0 2.2 0.5 2.0
Osteoporosis (self-reported) 0.6 0.7 2.4 1.5 0.3 -0.5 0.3
Osteoarthritis (self-reported) 0.1 0.2 0.3 0.3 -0.6 0.3 -0.5
Medication: Aspirin 0.7 0.9 1.4 -1.2 -0.9 1.2 0.2
Medication: Gliclazide 0.2 0.2 0.5 -0.1 -0.6 0.7 -0.0
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 -0.5 -0.7 0.3 -0.2
Smoking status: Current 0.1 0.2 0.6 0.4 -0.1 0.3 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.2 -1.5 -1.1 -0.3 -0.9
Whole body water mass 0.4 2.3 4.7 -1.6 0.5 -1.4 -2.2
Leg predicted mass (right) 0.5 2.4 5.2 -1.5 0.0 -1.5 -2.3
Arm fat mass (left) 0.4 1.6 3.2 -1.3 -0.8 -0.9 -1.8
Number of self-reported non-cancer illnesses 0.5 0.8 2.0 -1.4 0.2 0.1 1.1
Average weekly champagne plus white wine intake 0.0 0.0 0.1 0.3 0.2 0.1 -0.0
Miserableness 0.3 0.4 1.2 -0.5 -0.0 1.1 -0.5
Guilty feelings 0.3 0.4 0.8 -0.3 0.9 -0.5 -0.7
Wears glasses or contact lenses 0.1 0.1 0.3 -0.5 -0.3 -0.1 -0.1
Ever taken oral contraceptive pill 3.5 3.9 5.9 1.4 1.8 2.1 2.4
Hearing aid user 0.7 0.8 1.8 0.5 -1.4 1.0 -0.3
Mother’s age at death 0.1 0.2 0.4 -0.3 -0.6 -0.4 -0.3
Financial situation satisfaction 0.3 0.4 0.6 -0.4 0.8 -0.6 -0.6
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.2 1.1 0.8 0.1 0.8
Commuting to job workplace: Public transport 3.0 3.5 5.6 -1.0 -1.8 -2.1 -2.4
Eye problems/disorders: Glaucoma 0.4 0.5 1.0 -0.1 0.4 1.0 0.9
Medication: Blood pressure 2.5 4.7 9.0 -3.0 -2.1 -0.8 -2.2
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.0 -0.7 0.1 -1.0 -1.0
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.3 -0.8 -0.0 1.5 1.1
High cholesterol (Self-reported) 0.3 0.5 0.7 0.7 0.2 0.8 0.9
Medication: Bendroflumethiazide 1.0 1.5 2.4 -1.1 -1.5 -0.0 -1.6
Medication: Paracetamol 0.7 1.0 1.7 -0.7 -1.3 1.0 -1.0
Medication: Lisinopril 0.4 0.5 1.1 -0.6 -1.0 -0.3 0.5
Medication: Atorvastatin 2.8 3.4 6.7 -0.4 -2.5 -0.7 -2.6
Illnesses of father: High blood pressure 1.3 1.6 2.8 0.9 1.6 0.1 1.7
Alcohol drinker status: Never 0.5 0.6 1.3 1.1 0.6 0.4 0.7
Ever smoked 0.2 0.3 1.0 1.0 0.4 0.2 0.2
Basal metabolic rate 0.5 2.5 4.9 -1.7 0.2 -1.5 -2.2
Leg fat percentage (left) 0.2 0.6 1.2 -1.1 -0.5 -0.2 -0.9
Arm fat-free mass (left) 0.3 1.4 2.7 -1.3 0.7 -0.8 -1.6
Number of operations (self-reported) 1.2 1.8 4.3 0.2 0.6 2.1 1.6
Average weekly beer plus cider intake 0.2 0.3 0.6 0.5 0.8 0.3 -0.3
Irritability 0.6 1.1 3.8 -0.7 -0.1 2.0 -0.1
Risk taking 1.0 1.5 4.6 0.6 -0.9 2.1 0.2
Ever had prostate specific antigen (PSA) test 1.5 1.7 3.4 0.5 0.9 1.5 1.8
Fractured/broken bones in last 5 years 0.5 0.6 1.4 -0.6 0.8 -1.2 0.5
Age started oral contraceptive pill 2.7 3.3 5.9 -1.9 -2.4 -0.8 -1.8
Diastolic blood pressure, automated reading 0.5 1.4 2.7 1.1 1.4 -1.6 0.1
Ever depressed for a whole week 0.6 0.7 2.4 -0.1 0.1 1.6 0.7
Unable to work because of sickness or disability 0.3 0.4 0.9 0.3 -0.1 0.9 -0.8
Commuting to job workplace: Cycle 2.6 3.1 3.6 -1.8 -1.8 -1.9 -1.6
Myopia 0.8 1.1 2.0 0.3 1.4 -1.0 -1.2
Vascular/heart problems diagnosed by doctor 0.6 1.6 4.6 2.2 1.3 -0.2 0.1
Cholesterol lowering medication 0.9 1.3 2.5 -0.6 -1.2 -1.0 -1.6
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.1 0.3 -0.4 1.0 -0.3
Pain experienced in last month 1.3 2.1 2.7 1.5 1.0 1.6 1.6
Supplements: Calcium 0.8 0.9 2.2 1.5 0.1 0.8 0.8
Basal cell carcinoma (self-reported) 0.9 1.0 3.3 0.3 0.8 -1.8 0.3
Heart attack/myocardial infarction (self-reported) 1.5 2.0 3.9 -1.0 -1.6 2.0 0.5
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.6 -0.2 0.2 0.7 1.3
Heart disease (siblings) 2.0 2.4 7.1 -2.7 -1.4 -0.2 0.9
Alcohol drinker status: Previous 0.3 0.3 0.8 -0.1 -0.7 0.9 -0.2
Pack years of smoking 0.1 0.2 0.4 0.1 0.4 -0.7 0.3
Impedance of whole body 0.4 2.1 4.4 0.1 -1.8 2.1 0.9
Leg fat mass (left) 0.3 1.3 2.3 -1.4 -0.3 -0.9 -1.5
Arm predicted mass (left) 0.3 1.3 2.3 -1.1 0.8 -1.0 -1.5