Hub : Genes

MRGBP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.2630	0.0800	0.00330	0.124	NA	0.130	NA	0.102	6.7e-07	NA	3.5e-07	NA	6.5e-06
2	GTEx	Breast Mammary Tissue (Male)	0.1633	0.1310	0.16000	0.152	NA	0.017	NA	0.109	2.3e-04	NA	1.3e-01	NA	1.8e-03
3	GTEx	Breast Mammary Tissue (Female)	0.0809	0.0948	0.25000	0.003	NA	-0.009	NA	-0.009	2.6e-01	NA	7.5e-01	NA	7.6e-01
4	GTEx	Testis	0.2770	0.0780	0.00031	0.136	NA	0.216	NA	0.229	1.3e-06	NA	6.0e-10	NA	1.6e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.6	0.8	-0.0	0.0	0.5
Bipolar Disorder or Schizophrenia	0.3	0.8	2.2	1.5	0.4	0.0	0.9
Depressed Affect (Nagel 2018)	0.2	0.4	1.1	-0.4	0.2	1.1	-0.7
Depression (Nagel 2018)	0.1	0.2	0.9	0.0	-0.0	0.0	-0.9
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	-1.0	0.5	0.8	0.1
Neuroticism (Nagel 2018)	0.2	0.4	1.0	-0.7	0.1	0.2	-1.0
Schizophrenia (2018)	0.2	0.5	1.0	1.0	0.6	0.0	0.7
Schizophrenia vs Biploar Disorder	0.8	1.0	2.3	-1.3	0.0	0.0	-1.5
Worry (Nagel 2018)	0.2	0.3	0.9	-0.3	-0.5	0.2	-1.0
Alzheimer’s Disease (in mother)	0.9	1.1	1.9	0.6	1.2	1.4	0.7
Alzheimer’s Disease (in father)	0.9	0.9	1.4	1.1	1.2	-0.6	0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	0.8	1.0	0.4	0.8
Crohns Disease (2017)	0.1	0.2	0.4	0.6	-0.6	-0.1	-0.2
Irritable Bowel Disease (IBD)	0.2	0.4	1.0	1.0	0.1	-0.8	-0.1
Ulcerative Colitis (UC)	0.3	0.6	1.0	1.0	0.9	-0.4	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.4	2.7	6.1	2.5	0.7	-1.6	-1.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.2	-0.2	1.1	-0.6	-0.0
Breast Cancer	0.9	2.2	5.7	0.1	-1.7	-0.3	-2.4
Ovarian Cancer	0.5	0.6	1.0	0.7	-1.0	0.1	-1.0
Prostate Cancer	0.5	0.8	2.5	-0.5	-0.2	1.6	0.5
Age at First Birth	2.2	3.2	7.0	-1.6	-2.7	0.5	-1.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	3.1	-0.8	-0.1	-1.2	-1.8
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.2	0.9	-1.0	0.0	0.0	-0.1
Mean Putamen Volume	0.2	0.2	0.4	-0.7	-0.4	0.4	0.3
Fasting Glucose	0.3	0.3	0.9	-0.3	-0.0	0.9	0.6
HbA1C	0.4	0.4	1.3	0.7	-0.0	-1.1	-0.0
HDL Cholesterol	0.1	0.2	0.9	0.1	0.0	-0.1	1.0
LDL Cholesterol	0.2	0.4	0.7	-0.2	-0.8	0.8	0.3
Lupus	0.4	0.6	1.0	0.7	1.0	0.7	0.4
Neuroticism (2016)	2.3	3.4	9.8	-3.1	-0.9	-1.0	-1.4
Primary Biliary Cirrhosis	0.5	0.6	1.2	-0.8	0.7	-0.5	1.1
Rheumatoid Arthritis	0.0	0.1	0.2	-0.1	0.4	0.0	-0.2
Schizophrenia (2014)	0.2	0.4	1.6	1.3	0.0	0.0	0.3
Triglycerides	0.5	0.9	2.1	-0.4	-1.4	0.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.0	-0.6	-0.4	0.0	-1.4
Ulcerative Colitis	0.3	0.4	1.2	-0.5	-1.1	0.0	-0.4
Blood Eosinophil Count	0.0	0.3	1.0	-1.0	0.4	0.5	-0.1
Blood Platelet Count	0.2	1.8	5.7	2.4	-0.2	1.2	0.1
Blood Red Count	0.0	0.1	0.2	-0.2	0.5	-0.4	0.4
Blood White Count	0.0	0.3	0.5	-0.7	-0.4	0.7	-0.3
Heel T-Score	0.1	0.8	2.6	1.6	-0.5	-0.3	-0.5
BMI	0.2	1.4	3.1	0.5	0.9	-1.8	-1.1
Height	0.8	16.2	27.4	-4.9	-3.7	-0.2	-5.2
Waist Hip Ratio (WHR)	0.8	3.7	6.7	-0.5	-2.1	-1.8	-2.6
Systolic Blood Pressure	0.3	1.5	4.0	0.1	2.0	0.1	1.5
Smoking Status	0.1	0.3	0.7	-0.1	0.4	0.9	0.4
Allergy or Eczema	0.2	0.5	1.2	-0.1	1.1	-0.8	-0.1
Cardiovascular Disease	0.1	0.2	0.5	0.1	0.7	-0.3	0.5
Hypothyroidism (self reported)	0.3	0.7	1.4	-1.1	-0.6	-0.4	-1.2
Respiratory disease	0.3	0.7	1.1	0.4	0.9	0.8	1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.1	0.5	-0.8	-1.0	-0.2
Lung FEV1/FVC ratio	0.1	0.7	1.3	0.5	-0.5	-1.1	-1.0
Lung FVC	0.0	0.2	0.5	-0.5	-0.3	0.3	0.7
Neuroticism	0.7	1.7	3.2	-1.7	-0.2	-0.9	-1.8
Chronotype (morning person)	0.2	0.4	1.2	-1.1	-0.6	-0.1	-0.1
Hair Pigment	0.0	0.3	0.6	0.2	0.5	0.4	0.8
Tanning	0.3	3.8	10.7	-0.2	-0.6	3.3	2.0
Hand grip strength (left)	0.2	0.7	1.7	-1.3	0.4	0.8	0.4
Number of treatments/medications taken	0.4	0.8	1.4	-1.2	-1.2	0.6	-0.2
Average weekly spirits intake	0.7	0.9	2.2	0.3	0.7	1.5	0.9
Sensitivity / hurt feelings	0.5	0.9	2.0	-1.4	0.1	-0.6	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.5	0.9	0.1	-0.4
Hearing difficulty/problems: Yes	2.3	3.5	6.1	-1.6	-1.5	-1.7	-2.5
Relative age of first facial hair	0.2	0.5	1.1	1.0	0.6	-0.6	0.4
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	3.5	-0.4	-1.2	-1.0	-1.9
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.9	-0.5	-1.4	0.8	-0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.6	0.3	-0.2	0.1
Systolic blood pressure, automated reading	0.5	1.5	2.8	1.0	1.7	-0.4	1.5
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.8	-1.2	-1.7	0.7	-0.6
Angina	1.1	1.4	2.4	-1.6	-1.4	-0.4	-1.0
Medication for hormone replacement therapy	0.4	0.5	0.8	0.7	0.8	0.2	0.9
Vitamin and mineral supplements	0.9	1.2	2.4	-1.6	-0.5	-0.9	-1.1
Supplements: Zinc	1.2	1.3	1.8	1.4	1.3	0.8	1.0
Medication: Co-codamol	0.5	0.6	1.3	0.9	0.3	-1.1	-0.3
Medication: Metformin	3.9	5.5	13.8	-1.4	-1.3	-3.7	-2.1
Diabetes (father)	0.3	0.3	1.2	0.2	-0.2	-1.1	-0.2
Diabetes (mother)	0.3	0.4	1.1	0.3	0.1	1.1	-0.5
Severe depression (siblings)	1.6	1.7	4.0	-2.0	-0.7	-0.9	-1.3
Pack years adult smoking proportion	0.1	0.2	0.4	0.2	0.5	-0.7	0.3
Impedance of leg (right)	0.2	1.1	2.0	-0.3	-1.2	1.4	0.9
Leg fat-free mass (left)	0.5	2.7	5.9	-1.6	-0.1	-1.5	-2.4
Trunk fat percentage	0.2	1.0	2.0	-0.8	-1.1	-0.1	-1.4
Hand grip strength (right)	0.5	1.4	4.1	-2.0	0.5	1.0	0.2
Townsend deprivation index at recruitment	0.3	0.4	1.0	0.8	1.0	-0.1	0.0
Current tobacco smoking	0.1	0.1	0.2	0.4	-0.0	0.4	-0.5
Average weekly fortified wine intake	0.1	0.1	0.2	0.4	0.4	-0.1	-0.1
Maternal smoking around birth	0.6	0.8	2.1	-0.1	0.8	0.7	1.4
Fed-up feelings	0.1	0.3	0.5	-0.1	0.7	0.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.9	-0.5	-0.7	0.1	-1.4
Relative age voice broke	0.2	0.4	0.7	0.8	-0.3	-0.4	-0.8
Taking other prescription medications	0.3	0.4	0.8	-0.3	0.3	0.8	0.9
Age when periods started (menarche)	1.6	3.8	6.6	1.6	2.6	2.0	1.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.5	0.8	0.8	0.6	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.9	1.0	-0.8	-0.7	-0.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.2	-0.3	0.5	-1.5	-0.8
Qualifications: CSEs or equivalent	1.0	1.3	2.8	1.7	1.5	0.5	0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.2	0.0	-0.0	-0.2	0.4
High blood pressure	0.3	0.8	2.6	-1.6	-0.5	-0.0	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	0.4	0.8	-0.1	-0.3
Multivitamins +/- minerals	0.4	0.5	1.2	1.1	0.2	0.5	0.7
Stomach or abdominal pain in last month	0.3	0.4	0.7	-0.8	-0.7	0.7	-0.2
Supplements: Glucosamine	0.2	0.2	0.6	-0.2	0.8	0.4	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	0.8	0.1	-0.8	-0.5
Medication: Atenolol	0.6	0.7	1.2	-0.5	-1.0	0.6	-1.1
Medication: Levothyroxine sodium	0.2	0.4	0.8	0.1	-0.6	0.9	-0.5
Sitting height	0.1	0.4	1.4	-0.1	-0.3	0.2	-1.2
Chronic bronchitis/emphysema (father)	1.1	1.3	3.3	1.8	1.1	-0.0	0.7
High blood pressure (mother)	0.0	0.0	0.1	0.1	0.4	0.1	0.1
Body mass index (BMI)	0.2	0.9	1.5	-0.8	0.3	-1.2	-1.2
Impedance of leg (left)	0.3	1.5	3.1	-0.1	-0.9	1.8	1.4
Leg predicted mass (left)	0.5	2.8	5.9	-1.6	-0.2	-1.6	-2.4
Trunk fat mass	0.3	1.4	3.4	-1.1	-0.7	-0.6	-1.9
Waist circumference	0.9	3.3	6.6	-1.1	-0.6	-2.2	-2.6
Number of incorrect matches in round	1.3	2.1	4.4	0.6	0.3	2.1	1.9
Past tobacco smoking	0.1	0.2	0.5	-0.7	-0.5	-0.3	-0.0
Alcohol usually taken with meals	0.8	1.3	2.7	-1.2	-1.6	-0.6	-0.9
Nervous feelings	0.4	0.7	1.5	0.0	-0.3	-1.1	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.2	0.6	0.3	0.2
Hearing difficulty/problems with background noise	0.9	1.4	2.7	-1.0	-1.4	-0.5	-1.6
Hair/balding pattern: Pattern 2	0.2	0.3	1.0	-1.0	-0.4	-0.2	-0.2
Had menopause	0.2	0.2	0.3	0.4	-0.4	-0.6	-0.4
Had other major operations	0.5	0.6	2.4	0.1	0.3	1.5	0.1
Forced vital capacity (FVC)	0.0	0.1	0.2	-0.3	0.5	-0.0	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.8	1.9	0.1	-0.1	0.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.9	1.4	0.6	1.3	-0.0
Qualifications: None of the above	0.2	0.5	1.2	-1.1	-0.8	0.2	-0.2
Financial difficulties in last 2 years	0.9	1.2	1.7	-1.3	1.1	1.3	0.3
Mouth/teeth dental problems	0.1	0.2	0.3	-0.3	-0.5	0.5	0.3
Heart attack	1.4	1.8	3.9	-0.7	-1.5	2.0	0.5
Allergy	0.1	0.3	0.8	-0.5	-0.9	0.1	-0.5
Pain all over the body in last month	0.3	0.3	0.6	-0.3	0.6	-0.8	-0.3
Diabetes (self-reported)	0.2	0.2	0.6	-0.3	-0.8	-0.5	-0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	1.1	0.2	-0.8	-0.8
Medication: Ramipril	0.1	0.1	0.3	-0.1	-0.5	0.2	-0.1
Medication: Simvastatin	0.6	1.0	2.0	0.1	0.2	1.3	1.4
Fluid intelligence score	0.4	0.8	1.4	-0.0	1.2	0.9	1.0
Illnesses of siblings	1.1	1.5	2.6	1.6	1.4	1.0	0.6
Neuroticism score	0.3	0.6	1.3	-1.1	0.6	0.1	-0.9
Weight	0.5	2.4	5.3	-1.5	-0.5	-1.2	-2.3
Impedance of arm (right)	0.6	2.7	9.2	-0.7	-3.0	0.9	-0.7
Arm fat percentage (right)	0.5	1.8	3.1	-1.2	-1.5	-0.7	-1.8
Trunk fat-free mass	0.4	2.2	3.8	-1.5	0.7	-1.4	-1.9
Hip circumference	0.8	3.3	6.3	-1.7	-0.7	-1.9	-2.5
Time employed in main current job	1.8	2.1	4.9	-1.6	-2.2	0.1	-0.9
Alcohol intake versus 10 years previously	0.5	0.8	1.2	-0.8	-0.2	1.1	1.1
Father’s age at death	1.7	2.3	8.6	2.9	-0.2	0.6	0.3
Worrier / anxious feelings	0.3	0.5	1.0	-0.8	0.4	-1.0	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.4	-0.3	1.5	-0.5	0.2
Falls in the last year	0.6	0.8	2.9	1.7	-0.2	0.2	-0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	-0.1	0.7	-0.5	-0.2
Number of live births	2.4	3.4	4.3	2.1	1.9	1.1	2.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.9	-0.7	0.0	-1.3	-1.4
Pulse rate	0.8	1.3	3.8	1.9	1.1	0.1	-0.4
Happiness	0.5	0.6	2.0	-0.1	1.4	0.1	0.7
Noisy workplace	0.2	0.3	0.7	0.1	-0.1	0.6	0.8
Qualifications: A levels/AS levels or equivalent	0.4	1.0	3.1	0.4	0.0	-1.8	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	0.2	-0.8	-1.0	-1.3
Mouth/teeth dental problems: Dentures	0.8	1.3	3.0	-1.1	-1.7	0.5	-1.0
Asthma	1.9	3.8	5.1	2.2	2.3	0.9	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.2	-0.1	0.3	-0.7
Medication: Cholesterol lowering	1.0	1.5	3.2	-0.3	-0.2	1.7	1.8
Depression (self-reported)	0.5	0.6	1.6	0.5	0.3	1.3	0.7
Medication: Lansoprazole	0.9	1.1	2.4	-1.6	-1.3	-0.3	-0.4
Prospective memory result	0.3	0.4	1.0	-1.0	-0.3	-0.7	-0.4
Lung cancer (father)	0.5	0.5	1.0	-0.9	-1.0	0.4	-0.4
Illnesses of mother	0.3	0.3	0.7	0.1	-0.8	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.5	-1.6	-0.3	-1.0	-0.9
Pulse wave Arterial Stiffness index	0.3	0.3	1.1	-0.3	-1.1	0.3	-0.2
Impedance of arm (left)	0.5	2.2	6.7	-0.0	-2.6	1.5	-0.2
Arm fat mass (right)	0.5	2.1	4.0	-1.4	-0.8	-1.3	-2.0
Trunk predicted mass	0.4	2.1	3.8	-1.5	0.7	-1.4	-1.9
Standing height	0.3	3.2	6.6	-2.1	-1.4	-0.1	-2.6
Length of working week for main job	0.9	1.0	3.8	0.5	-0.1	1.9	0.3
Exposure to tobacco smoke at home	0.3	0.3	0.9	0.0	0.2	-0.6	-0.9
Breastfed as a baby	0.4	0.5	1.4	0.3	1.2	-0.6	0.1
Tense / ‘highly strung’	0.6	1.0	3.4	-0.6	-0.2	1.8	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.3	-0.2	1.0	0.3
Hair/balding pattern: Pattern 4	0.4	1.0	2.9	0.9	-0.3	1.7	0.4
Birth weight of first child	0.2	0.3	0.5	-0.7	-0.3	0.7	-0.3
Peak expiratory flow (PEF)	0.6	1.3	3.2	-0.1	0.7	-1.8	-1.2
Pulse wave reflection index	0.4	0.5	1.7	0.4	0.4	0.4	1.3
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.7	0.5	1.2	1.6	1.1
Loud music exposure frequency	0.9	1.0	1.9	-1.4	-1.2	0.3	-0.7
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.9	-0.5	0.6	-2.2	-1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	0.5	1.1	0.5	0.2
Blood clot in the leg (DVT)	0.3	0.4	1.2	-0.3	0.1	0.5	1.1
Medication: Paracetamol	0.8	1.3	2.0	0.5	-1.4	1.0	-1.3
Headache pain in last month	0.8	1.4	2.2	-1.2	-1.3	-0.5	-1.5
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	5.1	-0.4	-0.0	-2.0	-2.3
Glaucoma (self-reported)	1.6	1.9	3.6	0.9	0.8	1.5	1.9
Gout (self-reported)	0.3	0.4	1.4	-0.4	0.3	0.3	1.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.4	-0.1	0.5	0.3
Medication: Amlodipine	0.3	0.4	1.0	0.5	1.0	-0.6	0.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.7	1.1	1.9	-0.8	1.1
Birth weight	0.2	0.5	1.5	-0.8	0.2	0.2	-1.2
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.2	-1.1	-1.0	-1.5	-0.6
High blood pressure (siblings)	0.5	0.7	2.4	-0.1	-1.6	-0.3	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.5	1.5	-1.2	-0.3	-0.2	-0.6
Body fat percentage	0.3	1.1	1.9	-1.1	-1.0	-0.3	-1.4
Leg fat percentage (right)	0.3	0.9	1.5	-1.2	-0.8	-0.3	-1.2
Arm fat-free mass (right)	0.2	1.2	2.4	-0.8	1.1	-0.7	-1.5
Exposure to tobacco smoke outside home	0.5	0.6	1.5	-0.4	0.3	1.2	0.8
Comparative body size at age 10	0.4	1.1	2.6	-1.6	0.4	-1.2	-0.5
Number of full brothers	0.7	0.9	1.6	-0.1	1.3	1.0	1.0
Worry too long after embarrassment	1.3	2.1	3.7	-1.2	1.9	-1.8	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.1	-0.8	0.1	-0.8
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	0.2	-0.0	0.6	-0.2
Number of children fathered	1.6	1.8	4.0	-1.0	-2.0	-1.3	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-0.5	-0.1	0.9	-0.3
Age at first live birth	0.4	0.8	2.2	-0.1	0.8	-0.4	1.5
Pulse wave peak to peak time	0.2	0.3	0.9	0.2	0.9	-0.1	0.3
Health satisfaction	0.9	1.1	3.0	-1.7	-0.5	-0.9	-0.7
Shortness of breath walking on level ground	1.9	2.3	4.4	-1.2	-1.6	-0.8	-2.1
Qualifications: College or University degree	0.2	0.5	0.9	-0.6	-0.6	-1.0	-0.4
Eye problems/disorders: None of the above	0.4	0.4	0.6	0.8	-0.7	-0.4	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	-0.3	-0.9	1.0	-0.3
Emphysema/chronic bronchitis	0.5	0.6	1.2	-0.6	-0.0	1.1	0.9
Medication for pain relief, constipation, heartburn	0.9	1.5	3.5	0.5	1.3	-1.9	0.5
Neck or shoulder pain in last month	0.2	0.3	1.0	0.4	0.1	1.0	-0.1
Medication: Blood pressure	0.6	1.1	3.2	-0.1	0.2	1.1	1.8
Angina (self-reported)	1.1	1.4	2.4	-1.5	-1.5	-0.3	-1.0
Migraine (self-reported)	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.0
Medication: Ibuprofen	0.1	0.1	0.4	0.1	-0.1	-0.1	-0.7
Medication: Allopurinol	0.5	0.6	1.2	-0.8	-0.2	0.8	1.1
Medication: Omeprazole	0.1	0.1	0.3	-0.2	-0.4	0.3	-0.6
Medication: Seretide 50 evohaler	0.6	0.7	1.4	0.9	0.7	-1.2	-0.3
Mean time to correctly identify matches	1.1	2.1	5.5	2.3	-0.2	-1.0	-1.5
Heart disease (mother)	0.6	0.7	1.6	-0.6	0.5	0.9	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.2	0.3	-0.4	0.4
Whole body fat mass	0.5	2.2	4.3	-1.5	-0.8	-1.2	-2.1
Leg fat mass (right)	0.4	1.7	3.2	-1.4	-0.7	-1.0	-1.8
Arm predicted mass (right)	0.2	1.2	1.8	-1.0	1.2	-0.8	-1.3
Pulse rate, automated reading	0.4	1.1	4.0	2.0	0.5	0.2	-0.5
Alcohol intake frequency.	0.6	1.4	2.3	-1.0	-1.5	-1.3	-0.9
Comparative height size at age 10	0.6	3.2	7.3	-2.7	-1.6	-0.0	-1.8
Number of full sisters	1.0	1.2	2.4	-1.4	-0.4	-0.4	-1.6
Suffer from ‘nerves’	0.2	0.3	0.7	-0.4	-0.3	0.5	-0.9
Overall health rating	1.5	3.2	6.7	-0.6	-0.3	-2.4	-2.6
Chest pain or discomfort	1.0	1.4	5.2	0.2	-0.7	2.3	-0.1
Had major operations	0.5	0.5	1.0	-0.6	1.0	-0.2	0.9
Age at last live birth	0.9	1.3	3.2	0.8	1.1	-1.8	0.1
Family relationship satisfaction	0.6	0.8	1.0	-0.8	-0.6	-1.0	-1.0
Leg pain on walking	0.1	0.1	0.4	-0.6	0.3	0.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	0.3	-0.8	1.2	-0.3
Commuting to job workplace: Car/motor vehicle	1.9	2.2	3.5	1.3	1.9	1.4	1.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.9	-0.0	-1.1	-1.4	-1.3
Medication: Aspirin	0.5	0.7	1.4	-1.1	-0.5	1.2	0.2
Supplements: Vitamin C	2.3	2.7	4.3	1.9	0.1	1.7	2.1
Knee pain experienced in last month	0.5	0.8	1.3	-0.7	1.1	1.1	0.5
Hypertension (Self-reported)	0.2	0.6	1.9	-1.4	0.0	-0.2	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.7	-0.5	0.3	-0.1
Illnesses of father: Heart disease	3.2	4.5	6.6	-2.1	-2.2	-1.4	-2.6
Illnesses of siblings: Diabetes	1.0	1.2	1.6	-1.0	-0.8	-1.3	-1.3
Smoking status: Previous	0.4	0.6	1.3	0.9	1.1	0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.1	-1.5	-0.7	-0.1	-1.3
Whole body fat-free mass	0.4	2.5	4.8	-1.7	0.5	-1.5	-2.2
Leg fat-free mass (right)	0.4	2.3	4.9	-1.5	0.1	-1.5	-2.2
Arm fat percentage (left)	0.3	1.0	2.0	-0.9	-1.1	-0.5	-1.4
Average weekly red wine intake	0.0	0.0	0.1	0.2	0.2	0.2	0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.8	-0.1	0.9	0.3
Mood swings	0.4	0.8	1.2	-0.4	1.1	1.1	0.8
Loneliness, isolation	0.5	0.7	1.8	0.3	1.3	-0.2	-0.9
Long-standing illness, disability or infirmity	2.0	3.0	4.4	-2.0	-0.8	-2.1	-1.7
Ever had bowel cancer screening	1.1	1.3	3.1	-0.6	0.2	1.8	1.3
Diabetes diagnosed by doctor	0.4	0.6	1.1	-0.5	-0.9	-1.1	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.1	-0.2	-1.4	-0.4	-1.8
Friendships satisfaction	0.7	0.9	2.7	-0.4	1.6	-0.8	-0.1
Qualifications: nursing, teaching	2.0	3.1	4.2	-2.0	-1.9	-1.5	-1.5
Commuting to job workplace: Walk	0.5	0.5	1.1	0.2	0.9	-1.0	-0.4
Eye problems/disorders: Cataract	0.5	0.6	1.8	0.6	1.3	0.3	0.3
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	6.2	0.0	1.3	-2.5	-0.2
Medication for cholesterol	1.1	1.6	2.6	1.3	1.1	1.1	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.3	1.1	-0.2	0.1	-0.7
Back pain experienced in last month	0.3	0.4	0.7	0.6	0.8	0.2	0.8
Mineral and other dietary supplements	0.8	1.0	3.9	-0.2	0.2	-2.0	-0.5
Breast cancer (self-reported)	1.0	1.1	2.6	-1.6	0.2	1.2	0.7
Asthma (self-reported)	1.7	3.3	5.1	2.0	2.2	0.5	2.0
Osteoporosis (self-reported)	0.6	0.7	2.4	1.5	0.3	-0.5	0.3
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.3	-0.6	0.3	-0.5
Medication: Aspirin	0.7	0.9	1.4	-1.2	-0.9	1.2	0.2
Medication: Gliclazide	0.2	0.2	0.5	-0.1	-0.6	0.7	-0.0
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.5	-0.7	0.3	-0.2
Smoking status: Current	0.1	0.2	0.6	0.4	-0.1	0.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.2	-1.5	-1.1	-0.3	-0.9
Whole body water mass	0.4	2.3	4.7	-1.6	0.5	-1.4	-2.2
Leg predicted mass (right)	0.5	2.4	5.2	-1.5	0.0	-1.5	-2.3
Arm fat mass (left)	0.4	1.6	3.2	-1.3	-0.8	-0.9	-1.8
Number of self-reported non-cancer illnesses	0.5	0.8	2.0	-1.4	0.2	0.1	1.1
Average weekly champagne plus white wine intake	0.0	0.0	0.1	0.3	0.2	0.1	-0.0
Miserableness	0.3	0.4	1.2	-0.5	-0.0	1.1	-0.5
Guilty feelings	0.3	0.4	0.8	-0.3	0.9	-0.5	-0.7
Wears glasses or contact lenses	0.1	0.1	0.3	-0.5	-0.3	-0.1	-0.1
Ever taken oral contraceptive pill	3.5	3.9	5.9	1.4	1.8	2.1	2.4
Hearing aid user	0.7	0.8	1.8	0.5	-1.4	1.0	-0.3
Mother’s age at death	0.1	0.2	0.4	-0.3	-0.6	-0.4	-0.3
Financial situation satisfaction	0.3	0.4	0.6	-0.4	0.8	-0.6	-0.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	1.1	0.8	0.1	0.8
Commuting to job workplace: Public transport	3.0	3.5	5.6	-1.0	-1.8	-2.1	-2.4
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.1	0.4	1.0	0.9
Medication: Blood pressure	2.5	4.7	9.0	-3.0	-2.1	-0.8	-2.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.0	-0.7	0.1	-1.0	-1.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.3	-0.8	-0.0	1.5	1.1
High cholesterol (Self-reported)	0.3	0.5	0.7	0.7	0.2	0.8	0.9
Medication: Bendroflumethiazide	1.0	1.5	2.4	-1.1	-1.5	-0.0	-1.6
Medication: Paracetamol	0.7	1.0	1.7	-0.7	-1.3	1.0	-1.0
Medication: Lisinopril	0.4	0.5	1.1	-0.6	-1.0	-0.3	0.5
Medication: Atorvastatin	2.8	3.4	6.7	-0.4	-2.5	-0.7	-2.6
Illnesses of father: High blood pressure	1.3	1.6	2.8	0.9	1.6	0.1	1.7
Alcohol drinker status: Never	0.5	0.6	1.3	1.1	0.6	0.4	0.7
Ever smoked	0.2	0.3	1.0	1.0	0.4	0.2	0.2
Basal metabolic rate	0.5	2.5	4.9	-1.7	0.2	-1.5	-2.2
Leg fat percentage (left)	0.2	0.6	1.2	-1.1	-0.5	-0.2	-0.9
Arm fat-free mass (left)	0.3	1.4	2.7	-1.3	0.7	-0.8	-1.6
Number of operations (self-reported)	1.2	1.8	4.3	0.2	0.6	2.1	1.6
Average weekly beer plus cider intake	0.2	0.3	0.6	0.5	0.8	0.3	-0.3
Irritability	0.6	1.1	3.8	-0.7	-0.1	2.0	-0.1
Risk taking	1.0	1.5	4.6	0.6	-0.9	2.1	0.2
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.4	0.5	0.9	1.5	1.8
Fractured/broken bones in last 5 years	0.5	0.6	1.4	-0.6	0.8	-1.2	0.5
Age started oral contraceptive pill	2.7	3.3	5.9	-1.9	-2.4	-0.8	-1.8
Diastolic blood pressure, automated reading	0.5	1.4	2.7	1.1	1.4	-1.6	0.1
Ever depressed for a whole week	0.6	0.7	2.4	-0.1	0.1	1.6	0.7
Unable to work because of sickness or disability	0.3	0.4	0.9	0.3	-0.1	0.9	-0.8
Commuting to job workplace: Cycle	2.6	3.1	3.6	-1.8	-1.8	-1.9	-1.6
Myopia	0.8	1.1	2.0	0.3	1.4	-1.0	-1.2
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.6	2.2	1.3	-0.2	0.1
Cholesterol lowering medication	0.9	1.3	2.5	-0.6	-1.2	-1.0	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.1	0.3	-0.4	1.0	-0.3
Pain experienced in last month	1.3	2.1	2.7	1.5	1.0	1.6	1.6
Supplements: Calcium	0.8	0.9	2.2	1.5	0.1	0.8	0.8
Basal cell carcinoma (self-reported)	0.9	1.0	3.3	0.3	0.8	-1.8	0.3
Heart attack/myocardial infarction (self-reported)	1.5	2.0	3.9	-1.0	-1.6	2.0	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.6	-0.2	0.2	0.7	1.3
Heart disease (siblings)	2.0	2.4	7.1	-2.7	-1.4	-0.2	0.9
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.1	-0.7	0.9	-0.2
Pack years of smoking	0.1	0.2	0.4	0.1	0.4	-0.7	0.3
Impedance of whole body	0.4	2.1	4.4	0.1	-1.8	2.1	0.9
Leg fat mass (left)	0.3	1.3	2.3	-1.4	-0.3	-0.9	-1.5
Arm predicted mass (left)	0.3	1.3	2.3	-1.1	0.8	-1.0	-1.5