Hub : Genes

LAMA5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.056	0.025	5.2e-03	0.011	0.014	0.003	0.014	0.003	1.4e-02	0.0074	1.3e-01	0.0062	1.2e-01
2	GTEx	Artery Tibial	0.121	0.047	4.0e-03	0.054	NA	0.036	NA	0.031	4.8e-05	NA	7.4e-04	NA	1.8e-03
3	GTEx	Cells Transformed fibroblasts	0.140	0.038	4.1e-05	0.117	NA	0.103	NA	0.116	4.2e-09	NA	4.1e-08	NA	5.0e-09
4	GTEx	Esophagus Mucosa	0.175	0.049	9.8e-06	0.096	NA	0.090	NA	0.101	6.0e-07	NA	1.3e-06	NA	2.9e-07
5	GTEx	Liver	0.347	0.125	4.0e-03	0.114	NA	0.037	NA	0.084	4.5e-04	NA	3.3e-02	NA	2.4e-03
6	GTEx	Nerve Tibial	0.175	0.054	8.3e-04	0.036	NA	0.009	NA	0.052	1.4e-03	NA	7.5e-02	NA	1.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.7	1.2	5.7	2.4	-0.6	-0.2	-0.6	0.7	-0.0
Bipolar Disorder or Schizophrenia	0.5	1.1	2.5	1.1	-1.3	0.2	-1.6	1.1	-0.3
Depressed Affect (Nagel 2018)	0.8	1.8	3.7	-0.8	-1.5	1.1	1.6	-1.9	-0.4
Depression (Nagel 2018)	0.1	0.1	0.2	0.4	0.2	-0.3	0.3	-0.4	0.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.4	-0.5	-1.8	1.6	0.4	-1.0	-1.8
Neuroticism (Nagel 2018)	0.9	2.1	4.1	-0.9	-1.6	1.1	1.9	-2.0	0.4
Schizophrenia (2018)	0.4	0.8	2.4	-0.5	-1.0	0.4	-1.5	0.8	-0.4
Schizophrenia vs Biploar Disorder	1.8	2.4	6.4	-2.5	-1.2	0.0	1.5	-1.8	-1.2
Worry (Nagel 2018)	0.4	0.8	2.2	-1.0	-0.7	0.3	0.5	-0.7	1.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.8	0.1	0.1	-0.5	-0.9	0.7	-0.1
Alzheimer’s Disease (in father)	0.2	0.3	1.3	0.2	-0.1	0.0	-1.1	0.5	0.1
Alzheimer’s Disease (including proxy)	0.9	1.3	3.3	0.4	0.6	-1.0	-1.8	1.5	0.9
Crohns Disease (2017)	0.7	1.5	2.7	1.2	0.9	-1.3	-1.5	1.6	0.6
Irritable Bowel Disease (IBD)	0.8	2.0	4.2	1.1	0.9	-1.2	-1.9	2.0	0.6
Ulcerative Colitis (UC)	0.7	1.3	3.2	0.8	0.8	-0.8	-1.7	1.8	0.5
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	4.5	8.6	16.8	1.4	1.4	-2.9	-4.1	3.7	3.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.9	0.5	-0.1	0.9	0.1	-0.6	-0.7
Breast Cancer	0.7	1.8	3.6	0.6	0.9	-0.8	-1.7	1.9	1.6
Ovarian Cancer	0.4	0.5	1.3	1.1	-0.6	-0.3	-1.1	0.2	-0.1
Prostate Cancer	1.0	1.5	4.9	-1.0	0.6	-0.8	-2.2	1.4	0.3
Age at First Birth	0.2	0.3	1.4	1.2	0.2	0.1	0.2	-0.3	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	0.4	-0.6	0.3	-0.1	-0.0	0.4
Coronary Artery Disease (CAD)	0.2	0.2	0.5	-0.7	-0.5	-0.5	0.2	-0.4	-0.3
Crohns Disease (2012)	0.1	0.2	0.6	-0.1	0.8	0.1	-0.4	0.6	0.1
Mean Putamen Volume	1.3	1.4	7.5	-2.7	-0.7	0.1	-0.5	0.1	-0.6
Fasting Glucose	2.2	2.6	4.4	-2.1	-0.8	1.6	1.5	-1.1	-2.1
HbA1C	4.0	4.4	9.5	0.5	1.9	-2.5	-1.9	1.8	3.1
HDL Cholesterol	0.7	1.1	2.3	0.0	0.3	-0.9	-1.4	1.2	1.5
LDL Cholesterol	0.8	1.2	1.5	-1.1	-1.1	1.2	0.9	-1.1	-1.2
Lupus	0.8	1.2	1.9	0.9	-0.5	1.0	1.3	-1.4	-1.1
Neuroticism (2016)	0.3	0.4	0.8	-0.1	-0.7	0.6	0.7	-0.9	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.7	-1.3	0.4	0.8	0.2	0.0	-0.3
Rheumatoid Arthritis	1.8	2.5	4.6	0.3	-1.3	2.1	1.6	-1.7	-1.7
Schizophrenia (2014)	0.3	0.6	1.2	-0.4	-0.7	1.0	-1.1	0.5	-0.6
Triglycerides	0.3	0.5	1.8	-0.8	0.1	0.5	0.4	-0.6	-1.3
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.7	0.3	-0.8	-0.4	-0.3	0.2	0.7
Ulcerative Colitis	0.6	0.8	1.4	-0.6	0.8	-0.6	-1.1	1.2	1.0
Blood Eosinophil Count	0.2	1.7	2.6	0.7	1.3	-1.6	-1.2	1.3	1.5
Blood Platelet Count	2.8	33.0	48.0	4.8	5.2	-6.4	-6.4	6.9	4.2
Blood Red Count	0.3	2.6	7.1	-2.7	0.7	1.5	1.6	-1.5	-0.8
Blood White Count	0.9	6.9	11.5	2.0	2.7	-3.4	-2.2	2.6	2.7
Heel T-Score	1.1	8.7	15.3	3.1	1.0	-3.2	-3.9	3.4	2.1
BMI	0.0	0.1	0.3	-0.2	-0.4	0.1	0.5	-0.4	0.2
Height	2.7	51.8	72.1	-7.1	-5.6	7.9	8.5	-8.5	-4.7
Waist Hip Ratio (WHR)	0.3	1.4	4.2	-1.3	-0.0	-0.6	-2.0	1.3	-0.6
Systolic Blood Pressure	1.1	5.7	9.3	-2.4	-2.7	1.3	2.3	-3.0	-2.2
Smoking Status	1.5	3.6	8.4	-1.3	-0.5	1.9	2.9	-2.3	-1.4
Allergy or Eczema	0.8	2.1	9.6	-3.1	0.7	0.9	-0.4	-0.3	-1.2
Cardiovascular Disease	1.2	4.1	5.5	-1.9	-2.0	2.1	1.6	-2.0	-2.3
Hypothyroidism (self reported)	0.6	1.5	4.2	-2.1	-1.3	0.9	0.2	-0.2	-1.5
Respiratory disease	0.3	0.6	1.4	-1.0	0.6	-0.3	-0.8	1.2	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.8	0.9	0.3	-0.9	-0.8	0.8	0.5
Lung FEV1/FVC ratio	1.9	9.6	21.7	4.7	2.8	-3.3	0.3	1.9	3.6
Lung FVC	0.1	0.7	1.6	-0.4	0.8	1.3	0.3	0.2	-1.2
Neuroticism	1.4	3.3	5.6	-1.9	-2.3	1.0	1.9	-2.4	0.5
Chronotype (morning person)	0.4	0.9	2.5	1.0	-1.0	-0.4	0.6	-0.6	1.6
Hair Pigment	0.0	0.9	1.9	0.1	-1.4	0.6	1.0	-1.4	-0.3
Tanning	0.0	0.1	0.3	0.1	-0.6	-0.0	-0.0	0.1	-0.4
Hand grip strength (left)	1.1	3.0	6.8	-0.2	-1.2	2.0	2.6	-2.3	-0.8
Number of treatments/medications taken	2.4	4.3	11.7	-3.4	-1.9	1.8	0.9	-1.8	-1.6
Average weekly spirits intake	0.1	0.1	0.2	-0.3	-0.4	0.0	-0.3	0.3	-0.2
Sensitivity / hurt feelings	0.5	0.9	2.1	0.1	-1.5	0.1	1.1	-1.4	0.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.6	-0.0	0.0	0.3	-0.7	-0.3
Hearing difficulty/problems: Yes	2.1	3.2	9.7	-3.1	-1.1	1.3	1.4	-1.5	-1.6
Relative age of first facial hair	0.2	0.4	1.1	0.0	-0.8	1.1	0.5	-0.6	-0.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.9	-1.7	0.3	-0.0	-1.1	0.8	-0.9
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.3	-1.2	-0.5	1.8	1.0	-1.4	-1.1
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	-0.1	-0.3	0.7	0.5	-0.8	-0.2
Systolic blood pressure, automated reading	0.4	1.1	4.1	-2.0	-1.0	-0.5	0.1	-0.7	-0.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.8	-0.3	0.4	-0.1	-0.1	-0.0	-2.0
Angina	0.3	0.3	1.2	-0.3	-0.3	-0.4	0.5	-0.6	1.1
Medication for hormone replacement therapy	2.7	3.0	5.6	-2.0	-2.4	1.6	0.9	-1.4	-1.7
Vitamin and mineral supplements	0.6	0.8	1.4	0.1	-0.8	1.2	0.8	-1.0	-1.1
Supplements: Zinc	0.4	0.4	1.5	-0.3	0.3	-0.6	-1.2	0.8	-0.2
Medication: Co-codamol	0.1	0.1	0.4	-0.1	0.2	-0.0	-0.4	0.3	-0.6
Medication: Metformin	0.3	0.4	1.0	-1.0	0.8	-0.8	-0.5	0.2	0.0
Diabetes (father)	1.2	1.5	2.9	1.7	1.7	-0.6	-0.6	1.0	1.2
Diabetes (mother)	0.1	0.2	0.5	0.2	-0.4	0.3	-0.7	0.4	0.1
Severe depression (siblings)	0.2	0.2	0.6	0.0	0.0	-0.6	-0.1	-0.0	0.8
Pack years adult smoking proportion	0.2	0.2	0.6	0.7	0.0	-0.3	0.2	0.2	0.8
Impedance of leg (right)	0.1	0.3	0.8	0.1	0.8	0.2	0.3	-0.1	-0.9
Leg fat-free mass (left)	1.1	5.6	7.7	-2.7	-2.0	2.5	2.8	-2.5	-1.5
Trunk fat percentage	0.1	0.5	2.4	-1.5	0.3	0.3	0.1	-0.1	-0.7
Hand grip strength (right)	3.8	10.2	18.9	-0.9	-2.6	3.4	4.3	-4.2	-2.4
Townsend deprivation index at recruitment	2.1	3.0	5.7	-1.1	-1.8	1.7	1.4	-1.7	-2.4
Current tobacco smoking	0.1	0.2	0.8	-0.1	-0.1	-0.1	0.9	-0.2	0.6
Average weekly fortified wine intake	0.6	0.6	1.1	0.9	0.9	-0.5	-0.9	1.0	0.3
Maternal smoking around birth	0.3	0.5	2.2	-0.0	1.5	-0.5	0.4	0.3	0.6
Fed-up feelings	2.7	4.8	7.2	-2.6	-2.4	1.3	2.3	-2.7	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	3.5	-1.8	-0.9	1.2	1.8	-1.9	-1.3
Relative age voice broke	0.5	0.7	1.7	1.3	-0.2	-0.6	-0.6	0.5	1.2
Taking other prescription medications	4.0	6.2	15.4	-3.9	-1.6	2.5	2.0	-2.7	-1.5
Age when periods started (menarche)	0.3	0.6	1.9	1.4	0.3	-0.3	-0.9	0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	0.4	0.8	-0.6	-0.5	0.5	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.3	0.1	1.1	-1.5	-0.2	0.9	1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.4	-0.9	0.2	0.9	1.2	-0.9	-0.4
Qualifications: CSEs or equivalent	0.4	0.5	1.3	0.6	-0.4	0.7	0.6	-0.5	-1.2
Serious illness, injury or assault to yourself	0.3	0.3	1.0	-1.0	0.1	-0.3	-0.4	0.3	-0.8
High blood pressure	1.8	4.9	8.2	-2.4	-2.9	2.1	1.3	-2.4	-1.8
Hayfever, allergic rhinitis or eczema	0.7	1.4	7.1	-2.7	0.4	0.9	-0.2	-0.2	-0.6
Multivitamins +/- minerals	0.2	0.3	1.5	-1.2	0.1	-0.1	0.2	-0.2	-0.4
Stomach or abdominal pain in last month	0.8	1.0	1.9	-0.5	-1.2	1.4	0.9	-1.2	-0.0
Supplements: Glucosamine	1.3	1.7	3.6	-1.9	-1.4	0.9	0.3	-0.9	-1.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.3	-0.3	-0.3	-0.6	0.3	-0.3
Medication: Atenolol	2.9	3.6	8.7	-2.0	-3.0	1.6	1.2	-1.6	-1.5
Medication: Levothyroxine sodium	1.0	1.7	3.8	-1.9	-1.9	0.7	-0.4	-0.2	-1.3
Sitting height	1.0	6.8	13.7	-2.3	-2.4	2.5	3.7	-3.0	-0.8
Chronic bronchitis/emphysema (father)	1.1	1.3	3.1	0.6	0.3	-1.3	-1.2	1.2	1.8
High blood pressure (mother)	1.8	2.5	5.4	-1.7	-1.7	1.5	0.7	-1.1	-2.3
Body mass index (BMI)	0.1	0.4	1.6	-1.3	-0.4	0.2	0.4	-0.4	0.0
Impedance of leg (left)	0.0	0.2	0.7	0.3	0.8	0.0	0.3	-0.1	-0.5
Leg predicted mass (left)	1.1	5.8	8.0	-2.7	-2.0	2.6	2.8	-2.5	-1.5
Trunk fat mass	0.5	2.3	6.4	-2.5	-0.7	1.3	1.3	-1.3	-1.3
Waist circumference	0.5	1.6	6.4	-2.5	-1.1	0.9	0.3	-0.6	-1.0
Number of incorrect matches in round	0.5	0.8	3.3	-1.8	0.1	-0.0	-1.1	0.6	-0.3
Past tobacco smoking	3.8	7.0	10.1	2.8	2.0	-2.6	-3.1	3.2	1.8
Alcohol usually taken with meals	0.6	0.9	2.7	1.7	0.7	-0.6	-0.9	1.0	-0.2
Nervous feelings	0.5	0.8	2.8	-1.7	-1.1	0.1	0.2	-0.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	5.7	-2.4	0.1	-0.9	-0.2	0.3	1.5
Hearing difficulty/problems with background noise	4.3	6.8	23.7	-4.9	-1.3	2.3	1.2	-1.6	-2.5
Hair/balding pattern: Pattern 2	0.4	0.6	2.4	-0.7	0.2	0.4	0.5	-0.3	-1.5
Had menopause	1.1	1.4	2.9	-0.4	1.4	-1.0	-1.7	1.6	-0.1
Had other major operations	1.5	1.8	3.3	0.9	1.0	-1.1	-1.5	1.5	1.8
Forced vital capacity (FVC)	1.6	6.1	9.0	-2.4	-1.0	2.8	3.0	-2.3	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.9	0.7	0.3	-1.4	-0.3	0.7	1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	0.1	-0.1	1.1	0.1	-0.7	-0.9
Qualifications: None of the above	0.3	0.6	1.8	-0.8	0.3	0.1	1.3	-0.7	0.6
Financial difficulties in last 2 years	3.2	4.3	6.2	-1.8	-1.7	1.6	2.5	-2.3	-2.4
Mouth/teeth dental problems	0.1	0.2	0.9	-0.5	-0.1	0.1	0.2	0.0	-0.9
Heart attack	0.6	0.8	1.7	-1.1	-1.0	0.2	0.6	-1.3	-0.6
Allergy	0.9	2.1	10.5	3.2	-0.0	-1.0	-0.2	0.4	0.8
Pain all over the body in last month	0.3	0.3	0.9	-0.8	1.0	0.2	-0.1	0.3	-0.6
Diabetes (self-reported)	0.2	0.3	0.8	-0.4	-0.9	0.3	-0.3	-0.4	-0.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.6	1.6	0.4	-1.2	-1.6	1.1	0.9
Medication: Ramipril	1.0	1.3	2.6	-1.0	1.0	-0.7	-1.6	1.5	0.6
Medication: Simvastatin	1.7	2.5	3.6	-1.3	-1.5	1.6	1.7	-1.9	-1.4
Fluid intelligence score	0.1	0.2	0.4	0.5	-0.2	0.6	-0.0	-0.5	-0.3
Illnesses of siblings	7.1	9.9	20.2	4.5	1.8	-3.0	-3.1	3.2	2.6
Neuroticism score	2.4	4.9	8.7	-2.1	-2.5	1.8	2.4	-2.9	-0.8
Weight	1.1	5.4	9.6	-3.1	-1.6	2.2	2.7	-2.5	-1.4
Impedance of arm (right)	0.6	3.0	5.3	0.7	2.2	-1.6	-2.2	2.3	0.3
Arm fat percentage (right)	0.1	0.4	1.6	-1.2	0.5	-0.4	-0.5	0.5	0.2
Trunk fat-free mass	2.5	14.1	21.3	-3.6	-3.4	4.0	4.6	-4.2	-2.0
Hip circumference	0.8	3.5	6.1	-2.5	-1.3	1.7	2.0	-1.9	-1.4
Time employed in main current job	0.6	0.7	1.2	0.9	0.7	0.7	1.1	-0.9	-0.5
Alcohol intake versus 10 years previously	0.4	0.7	2.7	-0.1	0.6	-0.4	1.6	-0.7	0.5
Father’s age at death	5.3	7.1	12.8	3.6	0.7	-2.4	-2.9	3.0	2.5
Worrier / anxious feelings	0.5	0.9	4.2	-2.0	-0.5	0.2	0.6	-0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.5	18.7	-4.3	-1.8	2.1	1.6	-1.8	-0.8
Falls in the last year	0.3	0.3	0.6	0.5	0.8	-0.4	-0.3	0.5	0.8
Hair/balding pattern: Pattern 3	0.4	0.7	0.9	-0.9	-1.0	0.6	0.9	-0.9	-0.5
Number of live births	0.4	0.6	1.3	0.2	1.2	-0.7	-0.6	0.8	0.7
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	8.8	-1.5	-0.3	2.0	3.0	-1.6	-1.7
Pulse rate	2.0	3.4	5.0	2.2	2.0	-1.8	-1.6	2.2	0.7
Happiness	0.8	0.9	3.6	-1.9	0.2	-0.1	-0.8	0.2	-1.1
Noisy workplace	1.7	2.1	5.1	-1.3	-0.4	1.3	2.3	-1.9	-0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.7	-0.3	1.3	-0.2	-0.5	0.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.3	7.3	0.3	1.6	-1.9	-1.3	2.1	2.7
Mouth/teeth dental problems: Dentures	0.5	0.8	1.5	0.6	-0.8	0.5	1.1	-1.2	0.8
Asthma	0.2	0.4	0.9	-0.6	0.4	-0.4	-0.8	1.0	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	4.3	-2.1	-1.4	1.4	1.6	-1.3	-0.3
Medication: Cholesterol lowering	0.4	0.5	1.1	-0.3	-0.3	1.1	0.8	-1.0	-0.6
Depression (self-reported)	0.3	0.4	1.4	-0.3	0.1	0.2	1.2	-0.8	-0.0
Medication: Lansoprazole	2.1	2.4	3.6	-1.8	-1.3	1.3	1.8	-1.9	-0.7
Prospective memory result	0.6	0.8	2.0	-0.3	-0.0	0.7	1.4	-1.4	-0.3
Lung cancer (father)	0.2	0.2	0.4	0.4	0.6	0.0	0.6	-0.1	0.6
Illnesses of mother	0.9	1.1	2.9	1.6	0.4	-0.6	0.8	-0.4	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	9.1	-1.2	-0.5	2.2	3.0	-2.1	-1.8
Pulse wave Arterial Stiffness index	0.8	0.9	2.0	-1.4	-0.9	0.6	0.5	-0.4	-1.4
Impedance of arm (left)	0.7	3.2	5.7	1.1	2.2	-1.6	-2.2	2.4	0.1
Arm fat mass (right)	0.3	1.2	4.4	-2.1	-0.6	0.8	0.9	-0.9	-0.5
Trunk predicted mass	2.3	13.4	20.3	-3.5	-3.4	4.0	4.5	-4.2	-1.9
Standing height	1.6	16.0	26.1	-4.0	-2.7	4.2	5.1	-4.5	-2.8
Length of working week for main job	1.6	1.7	3.8	-1.9	0.8	1.1	2.0	-1.1	-0.4
Exposure to tobacco smoke at home	2.3	2.6	5.4	-1.2	-2.3	1.5	1.6	-1.9	-0.2
Breastfed as a baby	6.1	7.6	13.8	1.9	3.7	-2.7	-2.6	3.1	2.1
Tense / ‘highly strung’	0.5	0.9	2.0	-1.0	-1.4	0.2	-0.5	-0.2	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	6.3	-2.5	-1.1	1.4	1.5	-2.1	-0.3
Hair/balding pattern: Pattern 4	0.6	1.5	4.0	1.6	-0.1	-1.6	0.2	-0.1	2.0
Birth weight of first child	4.4	8.0	17.3	-1.7	-0.4	3.2	4.2	-3.5	-2.3
Peak expiratory flow (PEF)	0.6	1.4	3.3	-0.9	-0.5	1.2	1.8	-1.1	-1.1
Pulse wave reflection index	0.2	0.2	0.5	-0.6	-0.7	0.2	-0.3	0.1	-0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.7	0.8	0.3	0.8	1.1	-1.3	-0.2
Loud music exposure frequency	0.2	0.2	0.7	-0.1	0.2	0.4	0.7	-0.9	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-0.6	0.2	0.7	0.4	-0.4	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.5	0.5	1.6	-0.5	-0.4	0.7	0.4
Blood clot in the leg (DVT)	0.4	0.5	0.7	-0.2	0.7	-0.9	-0.6	0.8	0.8
Medication: Paracetamol	0.5	0.9	2.3	-1.3	-0.0	-0.0	-1.5	1.0	0.5
Headache pain in last month	0.6	1.0	2.3	-1.5	-1.4	1.0	0.2	-0.7	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	0.3	0.3	-1.0	-0.8	0.8	0.6
Glaucoma (self-reported)	0.5	0.6	1.4	-0.4	-0.9	0.4	0.8	-1.2	-0.5
Gout (self-reported)	1.0	1.3	5.0	-2.2	0.5	0.6	1.2	-0.8	-0.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.6	-1.9	-1.1	0.8	-0.4	-0.0	-1.8
Medication: Amlodipine	0.5	0.7	1.3	-0.2	-0.2	1.2	1.1	-1.1	-0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	-0.9	-1.2	-0.2	-0.3	0.2	0.7
Birth weight	5.0	10.9	18.6	-2.8	-2.7	4.3	3.4	-3.6	-2.6
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.0	-2.0	0.1	1.1	0.7	-0.5	-1.6
High blood pressure (siblings)	2.7	3.9	11.8	-3.4	-1.5	1.7	1.6	-1.8	-1.0
Forced vital capacity (FVC), Best measure	1.8	6.6	10.2	-2.1	-1.2	2.9	3.2	-2.6	-2.8
Body fat percentage	0.1	0.5	2.4	-1.6	0.1	0.2	0.2	-0.3	-0.6
Leg fat percentage (right)	0.2	0.8	3.0	-1.7	-0.5	0.4	0.6	-0.8	-0.7
Arm fat-free mass (right)	2.5	12.8	18.6	-3.1	-3.2	4.0	4.3	-4.1	-2.4
Exposure to tobacco smoke outside home	1.0	1.3	2.3	-1.3	-1.1	1.0	1.5	-1.2	0.1
Comparative body size at age 10	0.1	0.2	1.1	-0.2	1.0	0.0	-0.2	0.2	-0.1
Number of full brothers	1.5	1.9	2.9	-1.1	-1.6	1.7	0.9	-1.4	-1.4
Worry too long after embarrassment	3.1	5.2	8.0	-2.8	-2.0	2.0	2.4	-2.8	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	-1.1	-0.3	0.9	1.0	-1.3	-0.3
Wheeze or whistling in the chest in last year	1.8	3.3	4.4	-2.0	-1.4	2.1	1.4	-1.8	-2.0
Number of children fathered	0.3	0.4	0.9	-0.7	0.8	0.1	0.9	-0.4	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.3	1.1	0.3	-0.3	-0.6	0.2	-0.7
Age at first live birth	0.2	0.3	1.5	1.2	0.2	-0.4	0.0	-0.1	-0.6
Pulse wave peak to peak time	0.5	0.6	1.7	1.1	0.8	-0.3	-0.3	0.2	1.3
Health satisfaction	0.5	0.6	3.0	-1.7	-0.1	0.3	-0.5	-0.4	-0.3
Shortness of breath walking on level ground	1.2	1.4	3.6	-0.6	-1.7	1.2	-0.2	-0.3	-1.9
Qualifications: College or University degree	0.5	1.7	4.2	0.8	1.0	-0.8	-2.0	1.9	0.6
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.6	0.2	-0.3	-0.2	0.5	0.7
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.8	-0.7	-0.4	1.1	1.4	-1.1	-0.2
Emphysema/chronic bronchitis	5.7	6.4	10.4	-2.4	-1.7	2.8	3.2	-3.0	-1.6
Medication for pain relief, constipation, heartburn	0.8	1.3	5.3	2.3	1.1	-0.8	-0.4	0.6	0.3
Neck or shoulder pain in last month	2.1	2.9	6.9	-2.6	-1.8	1.5	1.5	-1.6	-0.8
Medication: Blood pressure	0.6	1.0	1.5	-1.2	-1.1	1.0	0.8	-1.1	-0.8
Angina (self-reported)	0.2	0.3	0.9	-0.2	-0.4	-0.2	0.6	-0.7	0.9
Migraine (self-reported)	0.4	0.6	1.9	0.5	0.7	0.6	1.4	-0.6	0.3
Medication: Ibuprofen	1.4	1.7	4.9	-2.2	-1.4	1.1	1.0	-1.1	-0.3
Medication: Allopurinol	0.9	1.2	5.0	-2.2	1.1	0.3	0.7	-0.6	-0.0
Medication: Omeprazole	0.5	0.6	2.8	-1.7	-0.3	0.1	0.2	-0.6	0.1
Medication: Seretide 50 evohaler	0.9	1.0	3.5	-1.9	-0.7	0.7	0.8	-0.7	-0.7
Mean time to correctly identify matches	3.9	7.4	14.9	1.0	1.2	-2.9	-3.9	3.3	2.7
Heart disease (mother)	1.0	1.2	5.0	-2.2	-1.0	0.4	0.6	-0.6	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.8	-0.2	-0.7	0.5	1.3	-1.3	-0.0
Whole body fat mass	0.5	2.0	6.3	-2.5	-0.6	1.2	1.3	-1.2	-1.0
Leg fat mass (right)	0.6	2.2	6.0	-2.5	-1.0	1.1	1.5	-1.5	-0.8
Arm predicted mass (right)	2.6	13.5	19.6	-3.3	-3.4	4.0	4.4	-4.2	-2.2
Pulse rate, automated reading	0.8	2.6	7.6	2.7	2.8	-0.5	-0.2	0.6	0.3
Alcohol intake frequency.	0.1	0.3	0.8	-0.9	0.1	-0.9	0.3	0.4	0.4
Comparative height size at age 10	1.6	9.1	16.2	-4.0	-1.5	3.2	3.4	-3.2	-2.0
Number of full sisters	3.8	4.6	10.7	-2.6	-0.4	1.9	3.3	-2.4	-0.9
Suffer from ‘nerves’	3.2	5.0	9.7	-2.2	-1.6	1.9	3.1	-3.0	-0.1
Overall health rating	2.2	4.7	12.3	-3.5	-2.7	1.6	1.1	-2.1	-0.9
Chest pain or discomfort	1.1	1.6	5.2	-2.3	-1.8	0.7	-0.2	-0.5	-0.7
Had major operations	0.4	0.5	1.2	-1.1	0.3	0.1	0.8	-0.6	0.8
Age at last live birth	0.2	0.3	0.7	-0.8	0.1	0.5	-0.2	0.2	-0.8
Family relationship satisfaction	0.3	0.4	1.0	-0.9	0.5	-0.0	-0.2	-0.2	-1.0
Leg pain on walking	3.3	4.1	7.7	-1.3	-2.4	2.8	1.6	-2.1	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.0	-0.8	-1.4	1.0	0.5	-0.8	-1.2
Commuting to job workplace: Car/motor vehicle	3.2	3.6	6.2	2.4	1.4	-1.9	-2.5	2.0	0.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.1	1.8	0.1	-0.2	-1.4	0.6	0.5
Medication: Aspirin	0.2	0.3	0.8	-0.4	0.4	0.5	0.9	-0.5	-0.5
Supplements: Vitamin C	2.2	2.6	4.0	0.8	1.7	-1.5	-1.5	2.0	1.8
Knee pain experienced in last month	1.4	2.1	6.2	-1.2	-0.5	0.9	2.5	-2.0	0.1
Hypertension (Self-reported)	1.2	3.3	6.4	-1.9	-2.5	1.6	1.3	-2.1	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.8	-0.7	-0.9	0.4	0.2	-0.6	-0.4
Illnesses of father: Heart disease	0.1	0.1	0.5	-0.7	0.4	0.2	0.2	-0.2	0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.7	-0.4	-0.1	0.6	0.9	-1.3	-0.5
Smoking status: Previous	3.7	5.5	7.1	-2.4	-1.4	2.7	2.5	-2.7	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	3.6	7.5	9.7	-2.6	-2.6	3.1	2.9	-2.7	-2.4
Whole body fat-free mass	2.0	11.4	16.6	-3.5	-3.0	3.6	4.1	-3.8	-1.9
Leg fat-free mass (right)	1.0	5.1	7.1	-2.5	-2.0	2.4	2.7	-2.4	-1.3
Arm fat percentage (left)	0.1	0.4	1.4	-1.2	0.4	-0.3	-0.6	0.5	-0.2
Average weekly red wine intake	0.1	0.1	0.2	-0.5	0.1	0.2	-0.4	0.1	-0.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.6	1.3	0.7	-0.5	0.4	-0.1	2.1
Mood swings	1.4	2.5	4.9	-1.3	-1.2	1.3	2.2	-2.2	-0.5
Loneliness, isolation	1.1	1.5	1.9	-1.3	-1.2	1.2	1.0	-1.4	-1.4
Long-standing illness, disability or infirmity	5.4	8.2	14.2	-3.8	-2.2	2.8	2.1	-2.7	-3.3
Ever had bowel cancer screening	5.1	6.0	9.2	-1.9	-2.6	3.0	2.3	-3.0	-1.5
Diabetes diagnosed by doctor	0.4	0.7	1.6	-0.5	-1.3	0.7	0.3	-0.9	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.7	0.4	-0.5	-0.6	0.6	0.3
Friendships satisfaction	0.9	1.1	2.8	-1.7	-0.9	1.0	0.6	-1.0	-0.8
Qualifications: nursing, teaching	2.4	3.7	8.5	1.3	1.9	-1.6	-2.9	2.4	0.1
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.1	-0.2	0.6	0.7	-0.7	-0.5
Eye problems/disorders: Cataract	0.4	0.4	0.9	1.0	-0.4	0.7	0.5	-0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.9	-1.0	0.2	-0.2	-0.9	0.4	0.8
Medication for cholesterol	3.9	6.0	8.0	2.1	2.8	-2.3	-2.1	2.8	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	8.5	-0.2	1.5	-1.7	-0.9	1.2	2.9
Back pain experienced in last month	1.5	2.1	7.3	-2.7	-1.7	1.0	0.9	-0.8	0.4
Mineral and other dietary supplements	0.5	0.6	2.0	1.1	0.2	0.2	0.7	-0.4	1.4
Breast cancer (self-reported)	1.2	1.5	4.6	-0.5	0.5	-0.4	1.5	-1.1	2.1
Asthma (self-reported)	0.3	0.5	1.2	-0.4	0.4	-0.5	-1.1	1.1	0.3
Osteoporosis (self-reported)	0.8	1.0	3.3	-1.8	1.0	-0.6	-0.9	0.6	0.2
Osteoarthritis (self-reported)	1.6	2.1	4.7	-1.4	-0.6	1.5	2.2	-1.6	-0.9
Medication: Aspirin	0.2	0.3	0.8	-0.3	0.3	0.4	0.9	-0.5	-0.5
Medication: Gliclazide	2.8	3.2	5.3	-2.3	-1.6	1.6	1.6	-2.2	-1.2
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.7	0.6	-0.3	0.3	-0.0	-0.2
Smoking status: Current	0.1	0.1	0.5	0.1	-0.1	-0.3	0.5	0.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.6	0.6	1.3	-0.8	-0.8	1.1	0.7
Whole body water mass	2.0	11.6	17.1	-3.3	-3.0	3.7	4.1	-3.8	-1.9
Leg predicted mass (right)	1.0	5.3	7.3	-2.6	-2.0	2.4	2.7	-2.5	-1.3
Arm fat mass (left)	0.3	1.2	4.2	-2.0	-0.5	0.8	1.0	-0.8	-0.6
Number of self-reported non-cancer illnesses	5.6	9.8	17.0	-4.1	-3.4	3.4	2.1	-2.8	-2.6
Average weekly champagne plus white wine intake	0.0	0.1	0.2	0.4	0.4	-0.1	-0.1	0.2	0.2
Miserableness	1.8	3.1	6.2	-0.6	-1.8	1.8	2.0	-2.5	-1.1
Guilty feelings	0.5	0.7	1.8	-0.1	-0.3	0.8	0.7	-1.0	-1.3
Wears glasses or contact lenses	0.1	0.1	0.3	0.0	0.5	0.1	-0.1	0.4	-0.2
Ever taken oral contraceptive pill	1.4	1.6	2.9	0.4	-1.0	1.3	1.7	-1.7	-0.9
Hearing aid user	0.0	0.0	0.1	-0.2	0.3	-0.2	-0.0	-0.1	0.2
Mother’s age at death	2.8	3.5	9.2	3.0	1.1	-1.3	-2.0	2.0	1.0
Financial situation satisfaction	1.4	1.7	7.1	-2.7	-0.6	0.4	0.7	-0.9	-1.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.6	-0.8	-0.1	-0.2	-0.4	0.4	-0.1
Commuting to job workplace: Public transport	2.5	2.9	4.5	-2.1	-0.8	1.9	2.1	-1.4	-1.5
Eye problems/disorders: Glaucoma	0.8	0.9	2.1	-0.3	-1.4	0.5	1.0	-1.5	-0.3
Medication: Blood pressure	1.5	2.9	5.7	-0.8	-2.4	1.4	1.7	-2.4	-0.8
Pain type(s) experienced in last month: Hip pain	1.3	1.7	5.9	-2.4	-0.5	1.2	0.9	-0.9	-0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.7	-1.7	-0.9	0.7	-0.3	-0.1	-1.9
High cholesterol (Self-reported)	0.6	1.1	1.8	-0.4	-0.9	1.3	1.1	-1.1	-1.2
Medication: Bendroflumethiazide	0.6	0.9	2.7	0.7	-1.6	0.9	0.4	-1.0	-0.7
Medication: Paracetamol	0.5	0.8	2.9	-1.7	-0.5	0.5	-0.9	0.1	-0.2
Medication: Lisinopril	0.7	0.9	2.4	-1.5	-1.5	-0.0	0.4	-0.8	-0.3
Medication: Atorvastatin	1.7	2.1	5.8	-0.2	1.3	-0.9	-2.4	2.0	0.3
Illnesses of father: High blood pressure	0.4	0.5	1.1	-0.6	-1.0	1.0	0.2	-0.4	-0.7
Alcohol drinker status: Never	0.5	0.6	1.1	-0.8	-0.1	0.5	1.1	-0.9	-0.8
Ever smoked	1.5	2.6	6.4	-1.5	-0.4	1.5	2.5	-2.0	-0.5
Basal metabolic rate	1.9	10.8	16.2	-3.5	-2.8	3.5	4.0	-3.7	-1.8
Leg fat percentage (left)	0.2	0.9	2.8	-1.7	-0.6	0.5	0.7	-0.9	-0.6
Arm fat-free mass (left)	2.4	12.0	17.4	-3.4	-3.3	3.6	4.2	-4.0	-1.9
Number of operations (self-reported)	0.3	0.5	0.9	-1.0	0.8	0.1	-1.0	0.6	0.1
Average weekly beer plus cider intake	0.5	0.8	3.5	1.9	-0.5	0.6	-0.3	0.2	-0.6
Irritability	2.2	3.7	5.6	-1.0	-2.0	2.2	2.0	-2.4	-1.6
Risk taking	1.1	1.5	4.6	-0.5	-1.0	1.6	0.8	-0.6	-2.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.2	1.1	-0.0	-0.6	-0.6	0.6	1.5
Fractured/broken bones in last 5 years	3.2	4.2	12.4	-3.5	-1.7	1.7	1.5	-1.7	-1.2
Age started oral contraceptive pill	0.2	0.2	0.6	-0.7	-0.2	-0.2	-0.2	-0.1	0.8
Diastolic blood pressure, automated reading	0.5	1.4	5.9	-2.4	-0.6	-0.8	-1.0	0.3	-0.6
Ever depressed for a whole week	1.0	1.2	3.4	-0.9	-0.7	1.8	0.6	-1.1	-0.9
Unable to work because of sickness or disability	1.2	1.6	3.3	-1.8	-0.0	1.2	1.8	-1.4	0.0
Commuting to job workplace: Cycle	0.5	0.6	1.3	-1.0	-0.1	0.7	1.2	-0.9	-0.2
Myopia	0.6	0.9	3.1	-1.8	0.5	0.4	0.6	-0.4	-1.1
Vascular/heart problems diagnosed by doctor	2.7	7.3	9.4	2.9	3.0	-2.6	-2.1	3.1	2.3
Cholesterol lowering medication	1.0	1.5	4.1	-2.0	-1.4	0.8	0.7	-1.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.7	-1.9	-0.6	0.4	0.5	-1.0	-0.0
Pain experienced in last month	2.3	3.9	9.8	3.1	1.4	-2.1	-1.9	1.7	0.7
Supplements: Calcium	0.2	0.2	0.4	-0.5	0.5	-0.2	-0.6	0.4	-0.3
Basal cell carcinoma (self-reported)	0.2	0.2	1.1	-0.3	1.0	-0.1	0.2	-0.1	0.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.9	-1.1	-0.9	0.3	0.7	-1.4	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	-0.0	1.0	-0.9	-0.4	0.8	0.8
Heart disease (siblings)	4.4	5.3	7.5	-2.7	-1.9	2.4	2.4	-2.5	-1.8
Alcohol drinker status: Previous	0.8	0.9	1.3	-0.4	-1.1	1.1	1.0	-0.9	-1.0
Pack years of smoking	0.1	0.1	0.5	0.5	-0.2	-0.2	0.1	0.1	0.7
Impedance of whole body	0.4	1.8	3.7	1.0	1.9	-1.2	-1.6	1.6	-0.1
Leg fat mass (left)	0.6	2.5	5.9	-2.4	-1.1	1.3	1.7	-1.7	-0.8
Arm predicted mass (left)	2.1	10.9	15.8	-3.1	-3.2	3.4	4.0	-3.8	-1.8