TWAS hub - MYT1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0845	0.0266	6.1e-08	0.039	0.061	0.054	NA	0.050	2.9e-05	2.0e-07	8.9e-07	NA	2.5e-06
2	TCGA	Thyroid Carcinoma	0.0960	0.0390	5.8e-04	0.005	0.036	0.025	NA	0.007	1.0e-01	1.9e-04	1.5e-03	NA	6.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Exposure to tobacco smoke outside home	7.6	10.1	12.7	-3.6	-2.7
Type 2 Diabetes (T2D) (2012)	6.1	7.0	9.3	3.0	2.2
HbA1C	5.7	6.4	8.1	-2.1	-2.9
Chronic bronchitis/emphysema (mother)	5.4	6.3	7.2	-2.3	-2.7
Pulse rate	4.8	8.1	9.0	-3.0	-2.7
Worry too long after embarrassment	4.6	7.7	10.3	3.2	2.3
Pulse rate, automated reading	4.1	13.2	17.4	-4.2	-3.0
Supplements: Fish oil (including cod liver oil)	4.1	5.3	6.2	-2.5	-2.1
Mineral and other dietary supplements	4.0	5.4	5.6	2.3	2.4
Ever used hormone-replacement therapy (HRT)	3.6	4.5	5.3	-1.9	-2.3
Mouth/teeth dental problems: Dentures	3.3	5.6	6.3	-2.2	-2.5
Sitting height	3.2	22.9	30.8	3.9	5.5
Ever had stillbirth, spontaneous miscarriage or termination	3.2	3.4	4.7	1.5	2.2
Medication: Co-codamol	3.1	3.6	4.3	-2.1	-1.7
Serious illness, injury or assault of a close relative in last 2 years	3.1	3.6	4.8	2.2	1.6
Pain experienced in last month	3.1	5.1	6.2	2.0	2.5
Maternal smoking around birth	2.9	4.2	5.9	-1.6	-2.4
Leg fat percentage (left)	2.9	10.3	18.2	-1.6	-4.3
Breast Cancer	2.8	6.7	11.7	3.4	1.3
Leg fat percentage (right)	2.8	10.0	17.6	-1.5	-4.2
Standing height	2.6	25.6	36.0	3.9	6.0
Medication: Gliclazide	2.6	3.0	4.8	2.2	1.0
Alzheimer’s Disease (including proxy)	2.5	3.7	4.6	1.7	2.1
Mouth/teeth dental problems	2.5	3.8	3.9	1.9	2.0
Diastolic blood pressure, automated reading	2.5	7.6	14.5	-0.9	-3.8
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	5.3	-0.5	-2.3
Loud music exposure frequency	2.4	2.6	4.2	-1.0	-2.0
Medication for pain relief, constipation, heartburn	2.4	4.1	7.7	0.7	2.8
Alzheimer’s Disease (in father)	2.2	2.4	3.1	1.3	1.8
Diabetes (mother)	2.0	2.6	4.6	0.7	-2.1
Depression (self-reported)	2.0	2.4	4.1	0.9	2.0
Exposure to tobacco smoke at home	2.0	2.2	3.3	-1.8	-1.1
Medication: Paracetamol	2.0	3.4	4.9	-2.2	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	6.1	1.4	2.5
Supplements: Glucosamine	1.9	2.5	2.7	-1.7	-1.5
Medication: Cholesterol lowering	1.9	3.0	5.7	2.4	-0.5
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	3.5	-1.6	1.9
Emphysema/chronic bronchitis	1.9	2.1	2.4	-1.4	-1.6
Eye problems/disorders: Cataract	1.9	2.2	4.4	0.0	2.1
Medication: Lisinopril	1.9	2.5	5.0	2.2	0.1
Severe depression (siblings)	1.8	2.0	2.2	-1.5	-1.4
Age when periods started (menarche)	1.8	4.3	8.1	0.6	2.9
Qualifications: A levels/AS levels or equivalent	1.8	3.9	4.7	2.2	1.8
Medication: Blood pressure	1.8	3.2	4.4	1.4	-2.1
Arm fat percentage (right)	1.7	6.9	10.2	-1.9	-3.2
Hair/balding pattern: Pattern 3	1.7	2.6	2.9	-1.7	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	4.0	-0.6	-2.0
Qualifications: College or University degree	1.7	5.5	10.1	0.9	3.2
Smoking Status	1.6	3.8	6.6	-1.0	-2.6
Hand grip strength (left)	1.6	4.2	7.2	2.7	1.1
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	2.6	1.6	1.1
Pain all over the body in last month	1.6	1.7	1.8	-1.3	-1.3
Glaucoma (self-reported)	1.6	1.9	3.5	-0.5	-1.9
Body fat percentage	1.6	6.5	11.1	-1.4	-3.3
Angina (self-reported)	1.6	2.1	2.9	1.7	-1.1
Cardiovascular Disease	1.5	4.9	7.7	1.4	-2.8
Angina	1.5	2.0	2.7	1.6	-1.2
Hand grip strength (right)	1.5	4.1	6.9	2.6	1.1
Birth weight of first child	1.5	2.6	5.2	-2.3	-0.2
Number of full brothers	1.5	1.9	2.1	-1.4	-1.3
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.3	1.8	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.0	-0.8	-1.7
High cholesterol (Self-reported)	1.5	2.7	3.6	1.9	-1.4
Vascular/heart problems diagnosed by doctor	1.5	4.2	6.0	-1.5	2.4
Heart disease (siblings)	1.5	1.9	3.6	0.4	-1.9
Systolic blood pressure, automated reading	1.4	4.0	7.2	0.9	-2.7
Heart attack	1.4	1.8	3.5	1.9	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	2.4	1.3	1.6
Birth weight	1.4	3.0	4.9	-2.2	-1.0
Health satisfaction	1.4	1.8	2.2	-1.2	-1.5
Arm fat percentage (left)	1.4	5.7	8.8	-1.6	-3.0
Friendships satisfaction	1.4	1.7	3.0	0.6	1.7
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	2.4	-1.5	1.5
Breast cancer (self-reported)	1.4	1.7	2.0	-1.4	-1.1
Medication: Atorvastatin	1.4	1.7	2.6	0.9	-1.6
Depression (Nagel 2018)	1.3	2.0	2.8	1.7	1.1
Financial difficulties in last 2 years	1.3	1.8	1.9	-1.4	-1.3
Mother’s age at death	1.3	1.6	2.8	0.6	1.7
Townsend deprivation index at recruitment	1.2	1.6	2.9	-1.7	-0.6
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.6	-0.2	-1.9
Handedness (chirality/laterality): Left-handed	1.2	1.4	1.5	1.2	1.2
Loneliness, isolation	1.2	1.7	2.1	1.5	1.1
Long-standing illness, disability or infirmity	1.2	1.9	2.0	-1.4	-1.3
Qualifications: nursing, teaching	1.2	1.9	3.4	0.6	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	2.9	1.7	0.2
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.0	1.7	-0.3
Alzheimer’s Disease (in mother)	1.1	1.3	1.9	0.8	1.4
Prostate Cancer	1.1	1.6	2.9	0.5	1.7
Height	1.1	21.4	27.2	4.0	5.2
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.0	0.9	1.4
Taking other prescription medications	1.1	1.6	2.5	-0.9	-1.6
Trunk fat-free mass	1.1	6.6	8.8	2.1	3.0
Trunk predicted mass	1.1	6.3	8.6	2.0	2.9
Hypertension (Self-reported)	1.1	2.9	3.7	1.5	-1.9
Systolic Blood Pressure	1.0	4.9	5.2	2.3	-2.2
High blood pressure	1.0	2.9	4.1	1.3	-2.0
Qualifications: None of the above	1.0	2.1	3.6	-0.8	-1.9
Medication: Simvastatin	1.0	1.5	3.1	1.8	-0.1
Prospective memory result	1.0	1.2	2.2	-0.4	-1.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.0	1.1	1.4
Medication: Amlodipine	1.0	1.4	2.6	-0.5	-1.6
Comparative body size at age 10	1.0	2.8	5.6	-0.2	-2.4
Medication: Seretide 50 evohaler	1.0	1.1	1.8	-1.3	-0.7
Chest pain or discomfort	1.0	1.4	2.5	1.6	0.6
Commuting to job workplace: Walk	1.0	1.0	1.4	-0.8	-1.2
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	-0.3	-1.5
Average weekly beer plus cider intake	1.0	1.5	2.8	1.7	-0.4
Bipolar Disorder (2018)	0.9	1.4	1.6	-1.1	1.3
Coronary Artery Disease (CAD)	0.9	1.1	1.8	1.3	-0.6
Schizophrenia (2014)	0.9	1.9	2.2	1.2	1.5
Trunk fat percentage	0.9	3.6	6.1	-1.0	-2.5
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.5	1.2	0.6
Body mass index (BMI)	0.9	3.9	6.7	-1.0	-2.6
Had other major operations	0.9	1.2	2.3	0.2	1.5
Happiness	0.9	1.1	1.6	-0.8	1.3
High blood pressure (siblings)	0.9	1.3	2.5	1.6	0.4
Eye problems/disorders: None of the above	0.9	1.0	2.1	-0.1	-1.4
Leg fat mass (right)	0.9	3.4	6.2	-0.8	-2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.8	-1.3	-0.6
Ever had bowel cancer screening	0.9	1.0	1.0	-1.0	-1.0
Medication: Aspirin	0.9	1.2	2.5	1.6	0.0
Alcohol drinker status: Never	0.9	1.1	1.5	-0.8	-1.2
Number of operations (self-reported)	0.9	1.3	1.5	1.2	1.0
Leg fat mass (left)	0.9	3.4	6.1	-0.8	-2.5
Vitamin and mineral supplements	0.8	1.0	1.5	1.2	0.7
Number of incorrect matches in round	0.8	1.3	1.4	1.2	1.1
Illnesses of siblings	0.8	1.1	2.0	-1.4	0.5
Peak expiratory flow (PEF)	0.8	2.0	2.1	1.4	1.4
Medication: Ibuprofen	0.8	1.0	2.0	0.1	-1.4
Comparative height size at age 10	0.8	4.5	4.8	2.0	2.2
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.7	0.4	1.3
Medication: Aspirin	0.8	1.1	2.1	1.4	-0.2
Illnesses of father: Heart disease	0.8	1.1	1.8	0.6	-1.4
Whole body fat-free mass	0.8	4.4	6.2	1.6	2.5
Osteoarthritis (self-reported)	0.8	1.0	2.0	-0.2	-1.4
Illnesses of father: None of the above (group 1)	0.8	0.9	1.9	-1.4	0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.9	1.4	-0.0
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.0	-1.0	-1.0
Medication: Bendroflumethiazide	0.8	1.2	1.9	1.4	0.7
Illnesses of father: High blood pressure	0.8	1.0	1.5	1.2	0.7
Unable to work because of sickness or disability	0.8	1.0	1.7	-0.6	1.3
Sensitivity / hurt feelings	0.7	1.1	1.7	1.3	0.7
Medication: Metformin	0.7	1.0	1.4	0.8	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.0	0.9	1.0
Time employed in main current job	0.7	0.8	1.6	0.1	1.3
Alcohol intake versus 10 years previously	0.7	1.0	1.9	-0.4	-1.4
Hair/balding pattern: Pattern 4	0.7	1.8	2.4	1.1	1.6
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.2	1.1	0.8
Arm fat-free mass (right)	0.7	3.4	4.0	1.7	2.0
Migraine (self-reported)	0.7	0.9	1.8	0.2	-1.3
Supplements: Vitamin C	0.7	0.9	1.5	-0.4	-1.2
Whole body water mass	0.7	4.2	6.1	1.5	2.5
Number of self-reported non-cancer illnesses	0.7	1.2	1.5	1.2	-0.9
Cholesterol lowering medication	0.7	1.0	1.3	0.9	-1.1
Ulcerative Colitis (UC)	0.6	1.1	1.2	-1.0	-1.1
BMI	0.6	3.2	6.0	-0.7	-2.4
Neuroticism	0.6	1.5	2.9	1.7	0.2
Fed-up feelings	0.6	1.0	1.4	-0.8	-1.2
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.4	0.5	1.5
Multivitamins +/- minerals	0.6	0.8	1.1	-1.0	-0.7
Stomach or abdominal pain in last month	0.6	0.8	1.5	-1.2	0.0
Medication: Atenolol	0.6	0.7	1.0	1.0	-0.7
Alcohol usually taken with meals	0.6	1.0	1.8	-0.6	-1.3
Falls in the last year	0.6	0.8	1.7	0.0	-1.3
Medication: Lansoprazole	0.6	0.7	1.4	-1.2	0.2
Arm fat mass (right)	0.6	2.4	3.8	-1.0	-2.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.2	-1.1	-0.6
Age at first live birth	0.6	1.0	1.8	0.4	1.4
Heart disease (mother)	0.6	0.7	0.8	0.8	-0.9
Whole body fat mass	0.6	2.6	4.6	-0.7	-2.2
Arm predicted mass (right)	0.6	3.0	3.4	1.6	1.8
Smoking status: Previous	0.6	1.0	1.4	-0.7	-1.2
Arm fat mass (left)	0.6	2.3	4.0	-0.7	-2.0
Commuting to job workplace: Public transport	0.6	0.7	1.4	0.1	1.2
Medication: Paracetamol	0.6	0.9	1.6	-1.2	-0.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.2	-0.4	1.1
Commuting to job workplace: Cycle	0.6	0.7	0.7	0.9	0.8
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.2	0.3	1.8
Neuroticism (Nagel 2018)	0.5	1.2	2.3	1.5	0.4
Blood Eosinophil Count	0.5	3.5	3.8	1.9	1.8
Blood White Count	0.5	3.6	6.2	2.5	1.0
Heel T-Score	0.5	3.9	5.5	-1.6	-2.3
Number of treatments/medications taken	0.5	0.9	1.4	-0.6	-1.2
Medication for hormone replacement therapy	0.5	0.5	1.0	-1.0	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.1	-0.5	-1.4
Past tobacco smoking	0.5	1.0	1.6	0.6	1.3
Nervous feelings	0.5	0.9	1.7	1.3	0.0
Forced vital capacity (FVC)	0.5	2.0	4.0	0.2	2.0
Medication: Ramipril	0.5	0.6	1.2	0.3	-1.1
Lung cancer (father)	0.5	0.6	1.2	-1.1	-0.0
Illnesses of mother	0.5	0.6	1.1	-1.0	0.4
Breastfed as a baby	0.5	0.7	0.9	1.0	0.6
Headache pain in last month	0.5	0.8	1.6	-1.3	-0.2
Mean time to correctly identify matches	0.5	0.9	1.8	0.3	-1.3
Suffer from ‘nerves’	0.5	0.7	0.7	0.8	-0.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	1.2	-1.1	-0.3
Illnesses of siblings: Diabetes	0.5	0.6	1.2	0.0	-1.1
Leg fat-free mass (right)	0.5	2.5	4.1	1.0	2.0
Back pain experienced in last month	0.5	0.7	1.3	-1.1	0.2
Osteoporosis (self-reported)	0.5	0.6	0.6	0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.4	-0.8	-1.2
Wears glasses or contact lenses	0.5	0.6	1.1	-1.0	0.3
Basal metabolic rate	0.5	2.7	3.5	1.4	1.9
Myopia	0.5	0.7	1.5	0.1	1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.7	-0.8	-0.7
Schizophrenia (2018)	0.4	0.8	1.6	1.2	0.2
Schizophrenia vs Biploar Disorder	0.4	0.5	0.5	-0.7	0.7
Body Mass Index (BMI) (2010)	0.4	0.6	0.8	-0.6	-0.9
HDL Cholesterol	0.4	0.7	1.4	0.2	1.2
LDL Cholesterol	0.4	0.7	1.2	0.3	-1.1
Neuroticism (2016)	0.4	0.6	1.1	0.5	-1.0
Primary Biliary Cirrhosis	0.4	0.5	0.8	0.9	0.5
Triglycerides	0.4	0.6	0.8	-0.9	-0.7
Allergy or Eczema	0.4	1.0	1.9	-0.2	1.4
Lung FVC	0.4	2.2	2.9	-1.7	-1.2
Leg fat-free mass (left)	0.4	1.9	3.1	0.8	1.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	-0.8	0.6
Leg predicted mass (left)	0.4	2.0	3.2	0.9	1.8
Waist circumference	0.4	1.6	3.1	-0.3	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.1	-0.8	-1.0
Allergy	0.4	1.0	2.0	0.1	-1.4
Fluid intelligence score	0.4	0.8	1.6	0.1	1.3
Asthma	0.4	0.7	1.1	0.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.8	0.4	0.9
Medication: Allopurinol	0.4	0.5	0.9	1.0	-0.2
Age at last live birth	0.4	0.6	0.9	0.5	0.9
Family relationship satisfaction	0.4	0.5	1.0	-1.0	0.1
Smoking status: Current	0.4	0.6	1.1	-0.1	-1.1
Leg predicted mass (right)	0.4	2.4	3.9	0.9	2.0
Arm fat-free mass (left)	0.4	2.2	2.5	1.4	1.6
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.3	-0.9
Worry (Nagel 2018)	0.3	0.7	1.2	1.1	-0.5
Reaction Time	0.3	0.6	1.1	1.0	-0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.3	0.4	1.1
Age at First Birth	0.3	0.4	0.8	-0.3	0.9
Mean Putamen Volume	0.3	0.4	0.7	0.2	0.8
Lupus	0.3	0.4	0.6	0.8	0.5
Blood Platelet Count	0.3	3.6	6.7	2.6	0.7
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.6	0.8	0.7
Lung FEV1/FVC ratio	0.3	1.6	2.5	0.8	-1.6
Hair Pigment	0.3	8.0	10.6	-3.3	-2.3
Pack years adult smoking proportion	0.3	0.4	0.8	0.9	-0.4
Current tobacco smoking	0.3	0.6	1.0	0.3	-1.0
Average weekly fortified wine intake	0.3	0.4	0.7	-0.2	-0.8
Medication: Levothyroxine sodium	0.3	0.5	1.0	0.1	-1.0
High blood pressure (mother)	0.3	0.4	0.9	0.1	-0.9
Trunk fat mass	0.3	1.4	2.7	-0.4	-1.7
Had menopause	0.3	0.3	0.3	-0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	0.9	0.9	0.5
Number of live births	0.3	0.4	0.7	0.8	-0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.8	0.6	1.4
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.7	-0.8	-0.0
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.1	0.9
Gout (self-reported)	0.3	0.4	0.8	0.9	-0.3
Neck or shoulder pain in last month	0.3	0.4	0.7	-0.4	-0.8
Number of full sisters	0.3	0.4	0.5	0.6	0.7
Had major operations	0.3	0.3	0.4	0.6	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	-0.0	-0.8
Diabetes diagnosed by doctor	0.3	0.4	0.6	0.5	0.7
Medication for cholesterol	0.3	0.5	0.9	0.0	1.0
Asthma (self-reported)	0.3	0.6	1.0	0.4	1.0
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.9	0.1
Guilty feelings	0.3	0.5	0.8	-0.3	-0.9
Hearing aid user	0.3	0.4	0.7	-0.2	-0.8
Medication: Blood pressure	0.3	0.6	0.8	0.7	-0.9
Ever smoked	0.3	0.6	1.1	-0.3	-1.0
Irritability	0.3	0.5	0.7	-0.8	0.6
Supplements: Calcium	0.3	0.3	0.5	0.4	-0.7
Pack years of smoking	0.3	0.5	0.5	0.7	-0.7
Arm predicted mass (left)	0.3	1.5	1.8	1.1	1.4
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	0.3	0.9
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	-0.1	-0.9
Fasting Glucose	0.2	0.2	0.3	0.6	0.3
Waist Hip Ratio (WHR)	0.2	1.0	2.0	0.0	-1.4
Respiratory disease	0.2	0.4	0.7	-0.8	0.5
Chronotype (morning person)	0.2	0.4	0.8	0.3	-0.9
Average weekly spirits intake	0.2	0.3	0.6	-0.7	0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.6	0.5
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	0.7	-0.2
Diabetes (father)	0.2	0.2	0.3	0.2	-0.6
Serious illness, injury or assault to yourself	0.2	0.2	0.2	0.5	-0.4
Diabetes (self-reported)	0.2	0.3	0.5	0.4	0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.3	0.6	0.4
Neuroticism score	0.2	0.5	1.0	1.0	0.1
Noisy workplace	0.2	0.2	0.3	0.6	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.6	0.8	0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.5	-0.2	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.7	1.3	0.3	1.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	-0.5	-0.7
Number of children fathered	0.2	0.2	0.3	0.5	-0.3
Pulse wave peak to peak time	0.2	0.2	0.2	0.5	0.4
Alcohol intake frequency.	0.2	0.6	0.7	-0.9	-0.6
Knee pain experienced in last month	0.2	0.4	0.6	-0.3	-0.8
Average weekly red wine intake	0.2	0.4	0.4	-0.7	-0.5
Financial situation satisfaction	0.2	0.2	0.4	-0.7	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.2	0.7
Depressed Affect (Nagel 2018)	0.1	0.1	0.2	0.4	-0.4
Crohns Disease (2017)	0.1	0.1	0.1	0.4	-0.3
Ovarian Cancer	0.1	0.1	0.2	0.1	-0.4
Crohns Disease (2012)	0.1	0.2	0.4	0.1	-0.6
Ulcerative Colitis	0.1	0.1	0.1	0.4	0.1
Hypothyroidism (self reported)	0.1	0.2	0.4	0.6	0.1
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.4	-0.0
Relative age of first facial hair	0.1	0.1	0.2	0.0	0.5
Supplements: Zinc	0.1	0.1	0.2	-0.1	-0.4
Relative age voice broke	0.1	0.1	0.2	0.4	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.5	0.1
Impedance of leg (left)	0.1	0.2	0.2	0.5	-0.5
Impedance of arm (right)	0.1	0.3	0.4	-0.7	0.3
Father’s age at death	0.1	0.1	0.3	0.1	0.5
Worrier / anxious feelings	0.1	0.1	0.2	0.3	-0.4
Impedance of arm (left)	0.1	0.6	1.1	-0.0	1.1
Length of working week for main job	0.1	0.2	0.3	0.6	-0.1
Pulse wave reflection index	0.1	0.1	0.3	-0.2	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.2	0.3
Shortness of breath walking on level ground	0.1	0.1	0.1	0.0	0.4
Medication: Omeprazole	0.1	0.1	0.1	-0.3	-0.2
Leg pain on walking	0.1	0.2	0.4	-0.1	0.6
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.4	0.3
Risk taking	0.1	0.2	0.3	-0.6	-0.0
Fractured/broken bones in last 5 years	0.1	0.2	0.3	0.3	0.5
Age started oral contraceptive pill	0.1	0.1	0.2	0.5	0.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.5	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.1	0.2	-0.1
Blood Red Count	0.0	0.4	0.5	-0.7	-0.5
Tanning	0.0	0.3	0.3	0.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.3	0.1
Impedance of leg (right)	0.0	0.2	0.2	0.5	-0.4
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.2	0.1
Hearing difficulty/problems with background noise	0.0	0.1	0.2	-0.1	-0.4
Hair/balding pattern: Pattern 2	0.0	0.1	0.1	-0.1	0.3
Weight	0.0	0.2	0.4	0.6	0.1
Hip circumference	0.0	0.2	0.4	-0.1	-0.6
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.1	-0.0
Tense / ‘highly strung’	0.0	0.1	0.1	0.3	0.2
Overall health rating	0.0	0.0	0.1	-0.2	-0.0
Mood swings	0.0	0.1	0.1	-0.0	0.4
Miserableness	0.0	0.1	0.1	-0.4	-0.1
Ever depressed for a whole week	0.0	0.0	0.0	-0.1	0.1
Impedance of whole body	0.0	0.0	0.1	0.1	0.3

Hub : Genes

MYT1

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Trait associations