[Hub]/) : Traits : Blood Platelet Count : ← →

chr22:36,707,661-39,966,547

Best TWAS P=3.22e-36 · Best GWAS P=1.64e-52 conditioned to 1.49e-22

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
114	The Cancer Genome Atlas	Thyroid Carcinoma	TST	0.05	0.04	lasso	2	0.04	9.9e-05	9.9	12.6	3.2e-36	0.81	0.00	0.95	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CBY1	0.04	0.02	blup	377	0.03	1.5e-04	6.1	-7.4	1.5e-13	0.02	0.88	0.04	TRUE
81	GTEx	Whole Blood	AL021977.1	0.08	0.00	enet	5	0.00	1.4e-01	5.7	7.2	6.3e-13	0.01	0.08	0.12	TRUE
62	GTEx	Skin Sun Exposed Lower leg	EIF3L	0.23	0.13	lasso	5	0.13	9.6e-11	6.3	6.6	3.6e-11	0.00	0.00	1.00	TRUE
8	GTEx	Adipose Subcutaneous	DNAL4	0.12	0.00	lasso	5	0.00	4.4e-01	-4.4	-6.2	5.7e-10	0.09	0.05	0.03	TRUE
111	The Cancer Genome Atlas	Thyroid Carcinoma	MPST	0.08	0.09	lasso	5	0.06	1.4e-06	9.9	10.8	3.8e-27	0.68	0.30	0.70	FALSE
109	The Cancer Genome Atlas	Soft Tissue Sarcoma	KCTD17	0.08	0.00	enet	7	0.00	4.7e-01	-4.7	-8.4	3.4e-17	-0.56	0.07	0.05	FALSE
105	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DNAL4	0.07	0.01	blup	46	0.03	7.4e-03	-5.0	-7.2	4.4e-13	0.01	0.03	0.27	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	SUN2	0.01	0.00	blup	60	0.00	1.4e-01	-4.7	-6.9	6.0e-12	0.01	0.01	0.21	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DDX17	0.04	0.02	lasso	6	0.03	1.2e-04	6.3	6.8	1.2e-11	-0.04	0.85	0.02	FALSE
108	The Cancer Genome Atlas	Prostate Adenocarcinoma	GCAT	0.09	0.00	blup	29	0.01	3.9e-02	5.8	-6.8	1.3e-11	0.00	0.00	0.70	FALSE
78	GTEx	Whole Blood	GCAT	0.24	0.19	lasso	5	0.19	6.1e-17	5.8	6.7	1.8e-11	0.01	0.04	0.96	FALSE
83	NTR	Blood	SUN2	0.03	0.02	bslmm	388	0.03	4.3e-09	6.4	6.7	2.1e-11	-0.02	0.92	0.08	FALSE
86	YFS	Blood	GCAT	0.50	0.40	lasso	9	0.43	3.2e-158	5.8	6.6	4.4e-11	0.01	0.04	0.96	FALSE
93	The Cancer Genome Atlas	Colon Adenocarcinoma	JOSD1	0.05	0.02	blup	50	0.04	2.7e-03	6.2	-6.6	4.9e-11	0.04	0.02	0.92	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	TOMM22	0.06	0.04	lasso	3	0.04	1.1e-04	6.2	-6.5	5.7e-11	0.05	0.04	0.96	FALSE
102	The Cancer Genome Atlas	Lung Adenocarcinoma	GTPBP1	0.02	0.04	lasso	3	0.03	2.5e-04	6.1	-6.5	9.4e-11	0.01	0.03	0.91	FALSE
39	GTEx	Esophagus Mucosa	SUN2	0.12	0.14	lasso	3	0.14	1.3e-09	6.1	-6.5	9.9e-11	0.03	0.99	0.01	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TOMM22	0.15	0.26	lasso	7	0.27	4.0e-33	6.2	-6.4	1.2e-10	0.04	0.95	0.05	FALSE
104	The Cancer Genome Atlas	Lung Adenocarcinoma	TOMM22	0.02	0.02	blup	43	0.02	1.7e-03	6.2	-6.4	1.3e-10	0.04	0.03	0.86	FALSE
18	GTEx	Artery Coronary	CBY1	0.26	0.20	lasso	4	0.22	8.3e-08	6.3	-6.3	2.1e-10	0.03	0.97	0.02	FALSE
25	GTEx	Artery Tibial	RP3-508I15.9	0.18	0.21	lasso	8	0.21	1.3e-16	6.2	-6.3	2.1e-10	0.03	0.97	0.03	FALSE
87	YFS	Blood	H1F0	0.42	0.34	lasso	7	0.42	6.3e-150	5.7	6.3	2.1e-10	0.00	0.09	0.91	FALSE
7	GTEx	Adipose Subcutaneous	TOMM22	0.11	0.02	lasso	5	0.01	6.5e-02	6.2	-6.3	2.7e-10	0.04	0.12	0.05	FALSE
22	GTEx	Artery Tibial	CBY1	0.23	0.28	lasso	6	0.26	1.9e-20	6.2	-6.3	2.8e-10	0.04	0.95	0.05	FALSE
71	GTEx	Testis	EIF3L	0.38	0.34	lasso	2	0.34	1.5e-15	6.3	6.3	2.8e-10	0.00	0.00	1.00	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	JOSD1	0.02	0.01	lasso	3	0.02	2.0e-05	-6.0	-6.3	2.8e-10	0.03	0.06	0.93	FALSE
107	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TOMM22	0.07	0.03	blup	43	0.04	8.8e-03	6.2	-6.3	2.8e-10	0.03	0.02	0.79	FALSE
116	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LOC646851	0.16	0.05	lasso	9	0.04	2.7e-02	5.7	6.3	2.9e-10	-0.01	0.01	0.47	FALSE
77	GTEx	Uterus	RP3-508I15.9	0.15	0.09	lasso	4	0.09	8.2e-03	6.2	-6.3	3.3e-10	0.04	0.20	0.09	FALSE
115	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	GCAT	0.17	0.05	blup	29	0.07	4.8e-03	5.7	-6.3	3.5e-10	0.01	0.03	0.37	FALSE
44	GTEx	Esophagus Muscularis	RP3-508I15.9	0.13	0.12	enet	23	0.10	1.1e-06	6.3	-6.3	3.6e-10	0.04	0.99	0.01	FALSE
58	GTEx	Skin Not Sun Exposed Suprapubic	TOMM22	0.13	0.11	lasso	6	0.11	7.9e-07	6.1	-6.3	3.7e-10	0.03	0.95	0.03	FALSE
37	GTEx	Esophagus Mucosa	MICALL1	0.06	0.01	enet	12	0.00	1.5e-01	5.4	6.2	4.0e-10	0.01	0.06	0.75	FALSE
46	GTEx	Lung	RP3-508I15.9	0.10	0.15	lasso	2	0.14	1.5e-10	6.2	-6.2	4.0e-10	0.04	0.96	0.04	FALSE
106	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC646851	0.08	0.06	blup	47	0.07	8.1e-04	5.6	6.2	4.0e-10	-0.05	0.04	0.88	FALSE
94	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	JOSD1	0.08	0.03	enet	5	0.04	3.4e-05	6.4	-6.2	4.3e-10	0.06	0.01	0.98	FALSE
64	GTEx	Skin Sun Exposed Lower leg	TOMM22	0.07	0.07	lasso	4	0.07	3.2e-06	6.2	-6.2	4.5e-10	0.04	0.93	0.04	FALSE
80	GTEx	Whole Blood	H1F0	0.10	0.04	enet	17	0.08	1.1e-07	5.7	6.2	4.5e-10	0.01	0.10	0.90	FALSE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC646851	0.13	0.11	enet	18	0.12	2.9e-13	6.2	6.2	4.5e-10	-0.03	0.01	0.99	FALSE
43	GTEx	Esophagus Muscularis	CBY1	0.15	0.16	lasso	2	0.14	1.2e-08	6.2	-6.2	4.6e-10	0.04	0.95	0.05	FALSE
73	GTEx	Testis	RP3-508I15.9	0.13	0.11	lasso	4	0.13	1.6e-06	6.1	-6.2	5.0e-10	0.02	0.93	0.04	FALSE
9	GTEx	Adipose Subcutaneous	RP3-508I15.9	0.16	0.23	lasso	3	0.22	3.5e-18	6.3	-6.2	5.8e-10	0.04	0.96	0.04	FALSE
10	GTEx	Adipose Visceral Omentum	CBY1	0.15	0.22	lasso	4	0.21	3.4e-11	6.2	-6.2	7.1e-10	0.04	0.96	0.04	FALSE
50	GTEx	Nerve Tibial	DDX17	0.10	0.09	lasso	5	0.07	1.2e-05	6.1	6.2	7.1e-10	-0.02	0.92	0.04	FALSE
55	GTEx	Ovary	CBY1	0.23	0.22	lasso	13	0.20	9.9e-06	5.7	-6.2	7.2e-10	0.05	0.62	0.03	FALSE
74	GTEx	Thyroid	TOMM22	0.06	0.09	lasso	1	0.07	9.8e-06	6.2	-6.2	7.3e-10	0.03	0.84	0.05	FALSE
26	GTEx	Brain Cerebellar Hemisphere	TOMM22	0.37	-0.01	lasso	11	-0.01	6.5e-01	6.1	-6.2	7.9e-10	0.02	0.07	0.06	FALSE
41	GTEx	Esophagus Mucosa	RP3-508I15.19	0.08	0.06	lasso	1	0.06	1.1e-04	6.1	-6.2	7.9e-10	0.01	0.89	0.02	FALSE
76	GTEx	Thyroid	RP3-508I15.22	0.09	0.09	lasso	6	0.09	4.1e-07	5.6	6.2	7.9e-10	-0.03	0.85	0.06	FALSE
29	GTEx	Breast Mammary Tissue	CBY1	0.11	0.08	lasso	6	0.07	1.5e-04	6.1	-6.1	8.0e-10	0.03	0.91	0.03	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAL4	0.03	0.01	blup	46	0.00	1.6e-01	-4.7	-6.1	1.1e-09	-0.02	0.02	0.17	FALSE
63	GTEx	Skin Sun Exposed Lower leg	CBY1	0.11	0.13	enet	22	0.12	2.1e-10	6.3	-6.1	1.2e-09	0.05	0.95	0.05	FALSE
31	GTEx	Breast Mammary Tissue (Female)	CBY1	0.13	0.03	lasso	2	0.00	3.0e-01	5.7	-6.1	1.3e-09	0.04	0.12	0.06	FALSE
66	GTEx	Skin Sun Exposed Lower leg	SUN2	0.06	0.06	lasso	3	0.05	5.3e-05	6.1	-6.0	1.5e-09	0.01	0.77	0.05	FALSE
67	GTEx	Skin Sun Exposed Lower leg	RP3-508I15.14	0.06	0.06	lasso	3	0.04	3.3e-04	6.1	-6.0	1.5e-09	0.01	0.79	0.04	FALSE
23	GTEx	Artery Tibial	TOMM22	0.07	0.10	lasso	3	0.09	8.2e-08	6.1	-6.0	1.9e-09	0.03	0.95	0.02	FALSE
11	GTEx	Adipose Visceral Omentum	RP3-508I15.9	0.15	0.14	lasso	4	0.14	1.5e-07	6.2	-6.0	2.0e-09	0.05	0.98	0.02	FALSE
36	GTEx	Esophagus Gastroesophageal Junction	RP3-508I15.9	0.12	0.12	lasso	2	0.09	3.2e-04	6.1	-6.0	2.2e-09	0.01	0.30	0.08	FALSE
85	YFS	Blood	EIF3L	0.02	0.01	lasso	3	0.01	1.7e-05	6.3	6.0	2.4e-09	0.01	0.00	0.99	FALSE
79	GTEx	Whole Blood	DDX17	0.05	0.00	lasso	4	0.00	4.1e-01	5.4	6.0	2.6e-09	-0.04	0.14	0.05	FALSE
17	GTEx	Artery Aorta	RP5-1039K5.17	0.07	0.04	lasso	2	0.04	3.0e-03	5.9	5.9	3.5e-09	-0.03	0.04	0.84	FALSE
35	GTEx	Esophagus Gastroesophageal Junction	CBY1	0.14	0.03	lasso	2	0.05	8.4e-03	-4.3	-5.9	3.6e-09	0.00	0.14	0.18	FALSE
51	GTEx	Nerve Tibial	CBY1	0.22	0.32	lasso	11	0.34	1.0e-24	6.3	-5.9	3.7e-09	0.05	0.99	0.01	FALSE
82	NTR	Blood	H1F0	0.23	0.21	lasso	3	0.21	1.2e-66	5.8	5.9	3.7e-09	0.02	0.04	0.96	FALSE
14	GTEx	Artery Aorta	CBY1	0.30	0.24	lasso	5	0.25	4.8e-14	5.2	-5.9	4.5e-09	0.04	0.99	0.01	FALSE
103	The Cancer Genome Atlas	Lung Adenocarcinoma	JOSD1	0.04	0.05	lasso	4	0.05	7.4e-07	6.0	-5.8	5.6e-09	0.03	0.04	0.96	FALSE
70	GTEx	Spleen	RP3-508I15.21	0.28	-0.01	enet	24	0.03	4.9e-02	1.3	-5.8	5.7e-09	-0.10	0.05	0.05	FALSE
49	GTEx	Muscle Skeletal	TOMM22	0.03	0.02	lasso	4	0.01	2.2e-02	6.1	-5.8	5.8e-09	0.04	0.50	0.06	FALSE
69	GTEx	Skin Sun Exposed Lower leg	RP3-508I15.19	0.05	0.04	lasso	2	0.04	4.9e-04	6.1	-5.8	5.8e-09	0.00	0.45	0.04	FALSE
34	GTEx	Colon Sigmoid	RP3-508I15.9	0.10	0.11	lasso	15	0.09	5.8e-04	6.2	-5.8	5.9e-09	0.05	0.66	0.15	FALSE
6	GTEx	Adipose Subcutaneous	CBY1	0.21	0.22	lasso	5	0.23	1.5e-18	6.2	-5.8	6.7e-09	0.05	0.98	0.02	FALSE
68	GTEx	Skin Sun Exposed Lower leg	RP3-508I15.9	0.22	0.28	lasso	10	0.30	1.6e-25	5.4	-5.8	6.7e-09	0.04	1.00	0.00	FALSE
38	GTEx	Esophagus Mucosa	JOSD1	0.16	0.24	lasso	2	0.25	1.3e-16	6.1	-5.8	7.1e-09	0.02	0.98	0.02	FALSE
72	GTEx	Testis	TOMM22	0.10	0.00	enet	23	0.01	8.4e-02	5.7	-5.8	7.8e-09	-0.02	0.02	0.78	FALSE
91	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOMM22	0.02	0.01	enet	11	0.01	1.1e-03	6.2	-5.8	8.1e-09	0.02	0.02	0.96	FALSE
20	GTEx	Artery Tibial	GCAT	0.09	0.09	lasso	2	0.08	3.5e-07	5.7	5.8	8.3e-09	-0.02	0.10	0.90	FALSE
3	CommonMind	Brain Pre-frontal Cortex	JOSD1	0.06	0.06	lasso	2	0.07	1.3e-08	5.2	-5.8	8.4e-09	0.04	0.99	0.01	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	POLR2F	0.02	0.02	blup	34	0.02	9.4e-03	6.0	5.8	8.4e-09	-0.04	0.01	0.74	FALSE
56	GTEx	Ovary	RP3-508I15.9	0.19	0.28	lasso	2	0.24	1.1e-06	5.7	-5.8	9.0e-09	0.04	0.75	0.04	FALSE
27	GTEx	Brain Cortex	RP3-508I15.9	0.21	0.12	lasso	7	0.10	1.1e-03	5.1	-5.7	9.3e-09	0.04	0.55	0.10	FALSE
54	GTEx	Nerve Tibial	RP3-508I15.9	0.26	0.38	lasso	10	0.40	5.6e-30	5.2	-5.7	1.2e-08	0.05	1.00	0.00	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	LOC646851	0.02	0.03	lasso	3	0.01	1.4e-02	5.6	5.7	1.2e-08	-0.05	0.02	0.82	FALSE
47	GTEx	Lung	RP3-508I15.22	0.05	0.04	lasso	1	0.03	1.8e-03	5.7	5.7	1.3e-08	-0.05	0.30	0.03	FALSE
57	GTEx	Pancreas	TOMM22	0.10	0.08	lasso	6	0.09	1.4e-04	6.2	-5.7	1.3e-08	0.03	0.73	0.03	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	GALR3	0.04	0.04	lasso	2	0.05	3.4e-06	5.6	5.7	1.4e-08	-0.03	0.08	0.90	FALSE
42	GTEx	Esophagus Muscularis	DDX17	0.08	0.10	lasso	1	0.07	3.9e-05	5.6	5.7	1.6e-08	-0.05	0.84	0.01	FALSE
95	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAL4	0.04	0.02	blup	46	0.03	1.1e-04	-4.3	-5.6	2.1e-08	-0.02	0.06	0.13	FALSE
13	GTEx	Artery Aorta	DDX17	0.07	0.03	lasso	4	0.04	2.1e-03	5.1	5.6	2.7e-08	-0.05	0.33	0.22	FALSE
48	GTEx	Muscle Skeletal	EIF3L	0.10	0.01	lasso	3	0.00	3.3e-01	6.3	5.5	2.8e-08	0.02	0.01	0.89	FALSE
12	GTEx	Artery Aorta	MICALL1	0.11	0.06	lasso	2	0.02	1.5e-02	5.6	5.5	2.9e-08	-0.03	0.06	0.90	FALSE
53	GTEx	Nerve Tibial	CBX6	0.14	0.01	enet	27	0.06	7.0e-05	4.7	5.5	2.9e-08	0.06	0.13	0.03	FALSE
19	GTEx	Artery Coronary	RP3-508I15.9	0.22	0.24	lasso	4	0.24	1.6e-08	5.2	-5.5	3.6e-08	0.05	0.98	0.01	FALSE
24	GTEx	Artery Tibial	C22orf23	0.08	0.05	lasso	2	0.05	4.2e-05	5.6	5.5	3.6e-08	-0.03	0.14	0.85	FALSE
97	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LGALS1	0.08	0.02	lasso	4	0.05	8.4e-04	4.9	-5.5	3.6e-08	0.06	0.00	0.65	FALSE
61	GTEx	Skin Not Sun Exposed Suprapubic	RP3-508I15.19	0.14	0.06	enet	39	0.03	7.8e-03	5.4	-5.5	3.8e-08	0.02	0.55	0.02	FALSE
60	GTEx	Skin Not Sun Exposed Suprapubic	RP3-508I15.9	0.17	0.17	lasso	3	0.17	1.4e-09	5.2	-5.5	4.0e-08	0.05	0.99	0.01	FALSE
59	GTEx	Skin Not Sun Exposed Suprapubic	SUN2	0.13	0.00	enet	36	0.02	2.9e-02	5.4	-5.5	4.3e-08	0.06	0.49	0.02	FALSE
65	GTEx	Skin Sun Exposed Lower leg	JOSD1	0.09	0.15	lasso	2	0.14	1.7e-11	5.4	-5.4	5.3e-08	0.05	1.00	0.00	FALSE
40	GTEx	Esophagus Mucosa	RP3-508I15.14	0.11	0.08	lasso	7	0.07	2.1e-05	5.4	-5.4	5.6e-08	0.03	0.97	0.01	FALSE
15	GTEx	Artery Aorta	C22orf23	0.10	0.01	enet	24	0.02	1.6e-02	5.4	5.4	5.8e-08	-0.04	0.08	0.71	FALSE
5	CommonMind	Brain Pre-frontal Cortex	TST	0.13	0.11	lasso	6	0.11	2.0e-13	-4.9	-5.4	5.9e-08	-0.35	0.99	0.01	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC646851	0.02	0.03	lasso	1	0.02	1.2e-03	5.4	5.4	6.1e-08	-0.05	0.04	0.71	FALSE
28	GTEx	Brain Putamen basal ganglia	RP5-1039K5.13	0.13	0.08	lasso	3	0.03	6.8e-02	5.9	5.4	7.1e-08	-0.04	0.08	0.39	FALSE
100	The Cancer Genome Atlas	Brain Lower Grade Glioma	TST	0.07	0.00	blup	72	0.03	3.8e-04	1.8	5.4	8.1e-08	0.24	0.01	0.04	FALSE
32	GTEx	Cells EBV-transformed lymphocytes	JOSD1	0.12	0.12	lasso	7	0.07	2.0e-03	5.6	-5.3	1.1e-07	0.06	0.39	0.04	FALSE
92	The Cancer Genome Atlas	Colon Adenocarcinoma	CBY1	0.07	0.11	enet	18	0.10	1.2e-06	5.2	5.3	1.1e-07	-0.05	0.19	0.81	FALSE
21	GTEx	Artery Tibial	MICALL1	0.11	0.04	lasso	4	0.05	8.4e-05	5.6	5.3	1.2e-07	-0.02	0.12	0.81	FALSE
88	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	JOSD1	0.02	0.01	blup	49	0.02	1.4e-02	5.4	-5.3	1.4e-07	0.05	0.04	0.50	FALSE
33	GTEx	Cells Transformed fibroblasts	RP3-508I15.9	0.31	0.43	lasso	15	0.43	6.2e-35	5.2	-5.2	1.5e-07	0.05	1.00	0.00	FALSE
52	GTEx	Nerve Tibial	TOMM22	0.11	0.08	lasso	4	0.08	5.2e-06	6.1	-5.2	1.5e-07	0.04	0.72	0.04	FALSE
45	GTEx	Lung	TOMM22	0.05	0.04	enet	11	0.04	3.8e-04	5.6	-5.2	1.9e-07	0.05	0.68	0.03	FALSE
30	GTEx	Breast Mammary Tissue	RP3-508I15.9	0.11	0.14	lasso	3	0.13	3.6e-07	5.1	-5.1	2.7e-07	0.04	0.98	0.00	FALSE
84	ROSMAP	Brain Pre-frontal Cortex	ANKRD54	0.03	0.00	blup	397	0.01	2.2e-02	5.6	-5.1	2.7e-07	0.00	0.07	0.65	FALSE
75	GTEx	Thyroid	JOSD1	0.12	0.08	enet	17	0.06	2.6e-05	3.7	5.1	2.8e-07	0.05	0.88	0.02	FALSE
16	GTEx	Artery Aorta	AL021977.1	0.13	0.00	enet	17	0.01	8.7e-02	2.1	-5.1	2.9e-07	0.01	0.10	0.19	FALSE