[Hub]/) : Traits : Blood Platelet Count :

chr22:36,707,661-39,966,547

Best TWAS P=3.22e-36 · Best GWAS P=1.64e-52 conditioned to 1.49e-22

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CBY1 0.04 0.02 blup 377 0.03 1.5e-04 6.1 -7.4 1.5e-13 0.02 0.88 0.04 TRUE
2 CommonMind Brain Pre-frontal Cortex DDX17 0.04 0.02 lasso 6 0.03 1.2e-04 6.3 6.8 1.2e-11 -0.04 0.85 0.02 FALSE
3 CommonMind Brain Pre-frontal Cortex JOSD1 0.06 0.06 lasso 2 0.07 1.3e-08 5.2 -5.8 8.4e-09 0.04 0.99 0.01 FALSE
4 CommonMind Brain Pre-frontal Cortex TOMM22 0.15 0.26 lasso 7 0.27 4.0e-33 6.2 -6.4 1.2e-10 0.04 0.95 0.05 FALSE
5 CommonMind Brain Pre-frontal Cortex TST 0.13 0.11 lasso 6 0.11 2.0e-13 -4.9 -5.4 5.9e-08 -0.35 0.99 0.01 FALSE
6 GTEx Adipose Subcutaneous CBY1 0.21 0.22 lasso 5 0.23 1.5e-18 6.2 -5.8 6.7e-09 0.05 0.98 0.02 FALSE
7 GTEx Adipose Subcutaneous TOMM22 0.11 0.02 lasso 5 0.01 6.5e-02 6.2 -6.3 2.7e-10 0.04 0.12 0.05 FALSE
8 GTEx Adipose Subcutaneous DNAL4 0.12 0.00 lasso 5 0.00 4.4e-01 -4.4 -6.2 5.7e-10 0.09 0.05 0.03 TRUE
9 GTEx Adipose Subcutaneous RP3-508I15.9 0.16 0.23 lasso 3 0.22 3.5e-18 6.3 -6.2 5.8e-10 0.04 0.96 0.04 FALSE
10 GTEx Adipose Visceral Omentum CBY1 0.15 0.22 lasso 4 0.21 3.4e-11 6.2 -6.2 7.1e-10 0.04 0.96 0.04 FALSE
11 GTEx Adipose Visceral Omentum RP3-508I15.9 0.15 0.14 lasso 4 0.14 1.5e-07 6.2 -6.0 2.0e-09 0.05 0.98 0.02 FALSE
12 GTEx Artery Aorta MICALL1 0.11 0.06 lasso 2 0.02 1.5e-02 5.6 5.5 2.9e-08 -0.03 0.06 0.90 FALSE
13 GTEx Artery Aorta DDX17 0.07 0.03 lasso 4 0.04 2.1e-03 5.1 5.6 2.7e-08 -0.05 0.33 0.22 FALSE
14 GTEx Artery Aorta CBY1 0.30 0.24 lasso 5 0.25 4.8e-14 5.2 -5.9 4.5e-09 0.04 0.99 0.01 FALSE
15 GTEx Artery Aorta C22orf23 0.10 0.01 enet 24 0.02 1.6e-02 5.4 5.4 5.8e-08 -0.04 0.08 0.71 FALSE
16 GTEx Artery Aorta AL021977.1 0.13 0.00 enet 17 0.01 8.7e-02 2.1 -5.1 2.9e-07 0.01 0.10 0.19 FALSE
17 GTEx Artery Aorta RP5-1039K5.17 0.07 0.04 lasso 2 0.04 3.0e-03 5.9 5.9 3.5e-09 -0.03 0.04 0.84 FALSE
18 GTEx Artery Coronary CBY1 0.26 0.20 lasso 4 0.22 8.3e-08 6.3 -6.3 2.1e-10 0.03 0.97 0.02 FALSE
19 GTEx Artery Coronary RP3-508I15.9 0.22 0.24 lasso 4 0.24 1.6e-08 5.2 -5.5 3.6e-08 0.05 0.98 0.01 FALSE
20 GTEx Artery Tibial GCAT 0.09 0.09 lasso 2 0.08 3.5e-07 5.7 5.8 8.3e-09 -0.02 0.10 0.90 FALSE
21 GTEx Artery Tibial MICALL1 0.11 0.04 lasso 4 0.05 8.4e-05 5.6 5.3 1.2e-07 -0.02 0.12 0.81 FALSE
22 GTEx Artery Tibial CBY1 0.23 0.28 lasso 6 0.26 1.9e-20 6.2 -6.3 2.8e-10 0.04 0.95 0.05 FALSE
23 GTEx Artery Tibial TOMM22 0.07 0.10 lasso 3 0.09 8.2e-08 6.1 -6.0 1.9e-09 0.03 0.95 0.02 FALSE
24 GTEx Artery Tibial C22orf23 0.08 0.05 lasso 2 0.05 4.2e-05 5.6 5.5 3.6e-08 -0.03 0.14 0.85 FALSE
25 GTEx Artery Tibial RP3-508I15.9 0.18 0.21 lasso 8 0.21 1.3e-16 6.2 -6.3 2.1e-10 0.03 0.97 0.03 FALSE
26 GTEx Brain Cerebellar Hemisphere TOMM22 0.37 -0.01 lasso 11 -0.01 6.5e-01 6.1 -6.2 7.9e-10 0.02 0.07 0.06 FALSE
27 GTEx Brain Cortex RP3-508I15.9 0.21 0.12 lasso 7 0.10 1.1e-03 5.1 -5.7 9.3e-09 0.04 0.55 0.10 FALSE
28 GTEx Brain Putamen basal ganglia RP5-1039K5.13 0.13 0.08 lasso 3 0.03 6.8e-02 5.9 5.4 7.1e-08 -0.04 0.08 0.39 FALSE
29 GTEx Breast Mammary Tissue CBY1 0.11 0.08 lasso 6 0.07 1.5e-04 6.1 -6.1 8.0e-10 0.03 0.91 0.03 FALSE
30 GTEx Breast Mammary Tissue RP3-508I15.9 0.11 0.14 lasso 3 0.13 3.6e-07 5.1 -5.1 2.7e-07 0.04 0.98 0.00 FALSE
31 GTEx Breast Mammary Tissue (Female) CBY1 0.13 0.03 lasso 2 0.00 3.0e-01 5.7 -6.1 1.3e-09 0.04 0.12 0.06 FALSE
32 GTEx Cells EBV-transformed lymphocytes JOSD1 0.12 0.12 lasso 7 0.07 2.0e-03 5.6 -5.3 1.1e-07 0.06 0.39 0.04 FALSE
33 GTEx Cells Transformed fibroblasts RP3-508I15.9 0.31 0.43 lasso 15 0.43 6.2e-35 5.2 -5.2 1.5e-07 0.05 1.00 0.00 FALSE
34 GTEx Colon Sigmoid RP3-508I15.9 0.10 0.11 lasso 15 0.09 5.8e-04 6.2 -5.8 5.9e-09 0.05 0.66 0.15 FALSE
35 GTEx Esophagus Gastroesophageal Junction CBY1 0.14 0.03 lasso 2 0.05 8.4e-03 -4.3 -5.9 3.6e-09 0.00 0.14 0.18 FALSE
36 GTEx Esophagus Gastroesophageal Junction RP3-508I15.9 0.12 0.12 lasso 2 0.09 3.2e-04 6.1 -6.0 2.2e-09 0.01 0.30 0.08 FALSE
37 GTEx Esophagus Mucosa MICALL1 0.06 0.01 enet 12 0.00 1.5e-01 5.4 6.2 4.0e-10 0.01 0.06 0.75 FALSE
38 GTEx Esophagus Mucosa JOSD1 0.16 0.24 lasso 2 0.25 1.3e-16 6.1 -5.8 7.1e-09 0.02 0.98 0.02 FALSE
39 GTEx Esophagus Mucosa SUN2 0.12 0.14 lasso 3 0.14 1.3e-09 6.1 -6.5 9.9e-11 0.03 0.99 0.01 FALSE
40 GTEx Esophagus Mucosa RP3-508I15.14 0.11 0.08 lasso 7 0.07 2.1e-05 5.4 -5.4 5.6e-08 0.03 0.97 0.01 FALSE
41 GTEx Esophagus Mucosa RP3-508I15.19 0.08 0.06 lasso 1 0.06 1.1e-04 6.1 -6.2 7.9e-10 0.01 0.89 0.02 FALSE
42 GTEx Esophagus Muscularis DDX17 0.08 0.10 lasso 1 0.07 3.9e-05 5.6 5.7 1.6e-08 -0.05 0.84 0.01 FALSE
43 GTEx Esophagus Muscularis CBY1 0.15 0.16 lasso 2 0.14 1.2e-08 6.2 -6.2 4.6e-10 0.04 0.95 0.05 FALSE
44 GTEx Esophagus Muscularis RP3-508I15.9 0.13 0.12 enet 23 0.10 1.1e-06 6.3 -6.3 3.6e-10 0.04 0.99 0.01 FALSE
45 GTEx Lung TOMM22 0.05 0.04 enet 11 0.04 3.8e-04 5.6 -5.2 1.9e-07 0.05 0.68 0.03 FALSE
46 GTEx Lung RP3-508I15.9 0.10 0.15 lasso 2 0.14 1.5e-10 6.2 -6.2 4.0e-10 0.04 0.96 0.04 FALSE
47 GTEx Lung RP3-508I15.22 0.05 0.04 lasso 1 0.03 1.8e-03 5.7 5.7 1.3e-08 -0.05 0.30 0.03 FALSE
48 GTEx Muscle Skeletal EIF3L 0.10 0.01 lasso 3 0.00 3.3e-01 6.3 5.5 2.8e-08 0.02 0.01 0.89 FALSE
49 GTEx Muscle Skeletal TOMM22 0.03 0.02 lasso 4 0.01 2.2e-02 6.1 -5.8 5.8e-09 0.04 0.50 0.06 FALSE
50 GTEx Nerve Tibial DDX17 0.10 0.09 lasso 5 0.07 1.2e-05 6.1 6.2 7.1e-10 -0.02 0.92 0.04 FALSE
51 GTEx Nerve Tibial CBY1 0.22 0.32 lasso 11 0.34 1.0e-24 6.3 -5.9 3.7e-09 0.05 0.99 0.01 FALSE
52 GTEx Nerve Tibial TOMM22 0.11 0.08 lasso 4 0.08 5.2e-06 6.1 -5.2 1.5e-07 0.04 0.72 0.04 FALSE
53 GTEx Nerve Tibial CBX6 0.14 0.01 enet 27 0.06 7.0e-05 4.7 5.5 2.9e-08 0.06 0.13 0.03 FALSE
54 GTEx Nerve Tibial RP3-508I15.9 0.26 0.38 lasso 10 0.40 5.6e-30 5.2 -5.7 1.2e-08 0.05 1.00 0.00 FALSE
55 GTEx Ovary CBY1 0.23 0.22 lasso 13 0.20 9.9e-06 5.7 -6.2 7.2e-10 0.05 0.62 0.03 FALSE
56 GTEx Ovary RP3-508I15.9 0.19 0.28 lasso 2 0.24 1.1e-06 5.7 -5.8 9.0e-09 0.04 0.75 0.04 FALSE
57 GTEx Pancreas TOMM22 0.10 0.08 lasso 6 0.09 1.4e-04 6.2 -5.7 1.3e-08 0.03 0.73 0.03 FALSE
58 GTEx Skin Not Sun Exposed Suprapubic TOMM22 0.13 0.11 lasso 6 0.11 7.9e-07 6.1 -6.3 3.7e-10 0.03 0.95 0.03 FALSE
59 GTEx Skin Not Sun Exposed Suprapubic SUN2 0.13 0.00 enet 36 0.02 2.9e-02 5.4 -5.5 4.3e-08 0.06 0.49 0.02 FALSE
60 GTEx Skin Not Sun Exposed Suprapubic RP3-508I15.9 0.17 0.17 lasso 3 0.17 1.4e-09 5.2 -5.5 4.0e-08 0.05 0.99 0.01 FALSE
61 GTEx Skin Not Sun Exposed Suprapubic RP3-508I15.19 0.14 0.06 enet 39 0.03 7.8e-03 5.4 -5.5 3.8e-08 0.02 0.55 0.02 FALSE
62 GTEx Skin Sun Exposed Lower leg EIF3L 0.23 0.13 lasso 5 0.13 9.6e-11 6.3 6.6 3.6e-11 0.00 0.00 1.00 TRUE
63 GTEx Skin Sun Exposed Lower leg CBY1 0.11 0.13 enet 22 0.12 2.1e-10 6.3 -6.1 1.2e-09 0.05 0.95 0.05 FALSE
64 GTEx Skin Sun Exposed Lower leg TOMM22 0.07 0.07 lasso 4 0.07 3.2e-06 6.2 -6.2 4.5e-10 0.04 0.93 0.04 FALSE
65 GTEx Skin Sun Exposed Lower leg JOSD1 0.09 0.15 lasso 2 0.14 1.7e-11 5.4 -5.4 5.3e-08 0.05 1.00 0.00 FALSE
66 GTEx Skin Sun Exposed Lower leg SUN2 0.06 0.06 lasso 3 0.05 5.3e-05 6.1 -6.0 1.5e-09 0.01 0.77 0.05 FALSE
67 GTEx Skin Sun Exposed Lower leg RP3-508I15.14 0.06 0.06 lasso 3 0.04 3.3e-04 6.1 -6.0 1.5e-09 0.01 0.79 0.04 FALSE
68 GTEx Skin Sun Exposed Lower leg RP3-508I15.9 0.22 0.28 lasso 10 0.30 1.6e-25 5.4 -5.8 6.7e-09 0.04 1.00 0.00 FALSE
69 GTEx Skin Sun Exposed Lower leg RP3-508I15.19 0.05 0.04 lasso 2 0.04 4.9e-04 6.1 -5.8 5.8e-09 0.00 0.45 0.04 FALSE
70 GTEx Spleen RP3-508I15.21 0.28 -0.01 enet 24 0.03 4.9e-02 1.3 -5.8 5.7e-09 -0.10 0.05 0.05 FALSE
71 GTEx Testis EIF3L 0.38 0.34 lasso 2 0.34 1.5e-15 6.3 6.3 2.8e-10 0.00 0.00 1.00 FALSE
72 GTEx Testis TOMM22 0.10 0.00 enet 23 0.01 8.4e-02 5.7 -5.8 7.8e-09 -0.02 0.02 0.78 FALSE
73 GTEx Testis RP3-508I15.9 0.13 0.11 lasso 4 0.13 1.6e-06 6.1 -6.2 5.0e-10 0.02 0.93 0.04 FALSE
74 GTEx Thyroid TOMM22 0.06 0.09 lasso 1 0.07 9.8e-06 6.2 -6.2 7.3e-10 0.03 0.84 0.05 FALSE
75 GTEx Thyroid JOSD1 0.12 0.08 enet 17 0.06 2.6e-05 3.7 5.1 2.8e-07 0.05 0.88 0.02 FALSE
76 GTEx Thyroid RP3-508I15.22 0.09 0.09 lasso 6 0.09 4.1e-07 5.6 6.2 7.9e-10 -0.03 0.85 0.06 FALSE
77 GTEx Uterus RP3-508I15.9 0.15 0.09 lasso 4 0.09 8.2e-03 6.2 -6.3 3.3e-10 0.04 0.20 0.09 FALSE
78 GTEx Whole Blood GCAT 0.24 0.19 lasso 5 0.19 6.1e-17 5.8 6.7 1.8e-11 0.01 0.04 0.96 FALSE
79 GTEx Whole Blood DDX17 0.05 0.00 lasso 4 0.00 4.1e-01 5.4 6.0 2.6e-09 -0.04 0.14 0.05 FALSE
80 GTEx Whole Blood H1F0 0.10 0.04 enet 17 0.08 1.1e-07 5.7 6.2 4.5e-10 0.01 0.10 0.90 FALSE
81 GTEx Whole Blood AL021977.1 0.08 0.00 enet 5 0.00 1.4e-01 5.7 7.2 6.3e-13 0.01 0.08 0.12 TRUE
82 NTR Blood H1F0 0.23 0.21 lasso 3 0.21 1.2e-66 5.8 5.9 3.7e-09 0.02 0.04 0.96 FALSE
83 NTR Blood SUN2 0.03 0.02 bslmm 388 0.03 4.3e-09 6.4 6.7 2.1e-11 -0.02 0.92 0.08 FALSE
84 ROSMAP Brain Pre-frontal Cortex ANKRD54 0.03 0.00 blup 397 0.01 2.2e-02 5.6 -5.1 2.7e-07 0.00 0.07 0.65 FALSE
85 YFS Blood EIF3L 0.02 0.01 lasso 3 0.01 1.7e-05 6.3 6.0 2.4e-09 0.01 0.00 0.99 FALSE
86 YFS Blood GCAT 0.50 0.40 lasso 9 0.43 3.2e-158 5.8 6.6 4.4e-11 0.01 0.04 0.96 FALSE
87 YFS Blood H1F0 0.42 0.34 lasso 7 0.42 6.3e-150 5.7 6.3 2.1e-10 0.00 0.09 0.91 FALSE
88 The Cancer Genome Atlas Bladder Urothelial Carcinoma JOSD1 0.02 0.01 blup 49 0.02 1.4e-02 5.4 -5.3 1.4e-07 0.05 0.04 0.50 FALSE
89 The Cancer Genome Atlas Breast Invasive Carcinoma JOSD1 0.02 0.01 lasso 3 0.02 2.0e-05 -6.0 -6.3 2.8e-10 0.03 0.06 0.93 FALSE
90 The Cancer Genome Atlas Breast Invasive Carcinoma SUN2 0.01 0.00 blup 60 0.00 1.4e-01 -4.7 -6.9 6.0e-12 0.01 0.01 0.21 FALSE
91 The Cancer Genome Atlas Breast Invasive Carcinoma TOMM22 0.02 0.01 enet 11 0.01 1.1e-03 6.2 -5.8 8.1e-09 0.02 0.02 0.96 FALSE
92 The Cancer Genome Atlas Colon Adenocarcinoma CBY1 0.07 0.11 enet 18 0.10 1.2e-06 5.2 5.3 1.1e-07 -0.05 0.19 0.81 FALSE
93 The Cancer Genome Atlas Colon Adenocarcinoma JOSD1 0.05 0.02 blup 50 0.04 2.7e-03 6.2 -6.6 4.9e-11 0.04 0.02 0.92 FALSE
94 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma JOSD1 0.08 0.03 enet 5 0.04 3.4e-05 6.4 -6.2 4.3e-10 0.06 0.01 0.98 FALSE
95 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DNAL4 0.04 0.02 blup 46 0.03 1.1e-04 -4.3 -5.6 2.1e-08 -0.02 0.06 0.13 FALSE
96 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LOC646851 0.02 0.03 lasso 1 0.02 1.2e-03 5.4 5.4 6.1e-08 -0.05 0.04 0.71 FALSE
97 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma LGALS1 0.08 0.02 lasso 4 0.05 8.4e-04 4.9 -5.5 3.6e-08 0.06 0.00 0.65 FALSE
98 The Cancer Genome Atlas Brain Lower Grade Glioma GALR3 0.04 0.04 lasso 2 0.05 3.4e-06 5.6 5.7 1.4e-08 -0.03 0.08 0.90 FALSE
99 The Cancer Genome Atlas Brain Lower Grade Glioma LOC646851 0.13 0.11 enet 18 0.12 2.9e-13 6.2 6.2 4.5e-10 -0.03 0.01 0.99 FALSE
100 The Cancer Genome Atlas Brain Lower Grade Glioma TST 0.07 0.00 blup 72 0.03 3.8e-04 1.8 5.4 8.1e-08 0.24 0.01 0.04 FALSE
101 The Cancer Genome Atlas Lung Adenocarcinoma DNAL4 0.03 0.01 blup 46 0.00 1.6e-01 -4.7 -6.1 1.1e-09 -0.02 0.02 0.17 FALSE
102 The Cancer Genome Atlas Lung Adenocarcinoma GTPBP1 0.02 0.04 lasso 3 0.03 2.5e-04 6.1 -6.5 9.4e-11 0.01 0.03 0.91 FALSE
103 The Cancer Genome Atlas Lung Adenocarcinoma JOSD1 0.04 0.05 lasso 4 0.05 7.4e-07 6.0 -5.8 5.6e-09 0.03 0.04 0.96 FALSE
104 The Cancer Genome Atlas Lung Adenocarcinoma TOMM22 0.02 0.02 blup 43 0.02 1.7e-03 6.2 -6.4 1.3e-10 0.04 0.03 0.86 FALSE
105 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma DNAL4 0.07 0.01 blup 46 0.03 7.4e-03 -5.0 -7.2 4.4e-13 0.01 0.03 0.27 FALSE
106 The Cancer Genome Atlas Pancreatic Adenocarcinoma LOC646851 0.08 0.06 blup 47 0.07 8.1e-04 5.6 6.2 4.0e-10 -0.05 0.04 0.88 FALSE
107 The Cancer Genome Atlas Pancreatic Adenocarcinoma TOMM22 0.07 0.03 blup 43 0.04 8.8e-03 6.2 -6.3 2.8e-10 0.03 0.02 0.79 FALSE
108 The Cancer Genome Atlas Prostate Adenocarcinoma GCAT 0.09 0.00 blup 29 0.01 3.9e-02 5.8 -6.8 1.3e-11 0.00 0.00 0.70 FALSE
109 The Cancer Genome Atlas Soft Tissue Sarcoma KCTD17 0.08 0.00 enet 7 0.00 4.7e-01 -4.7 -8.4 3.4e-17 -0.56 0.07 0.05 FALSE
110 The Cancer Genome Atlas Thyroid Carcinoma LOC646851 0.02 0.03 lasso 3 0.01 1.4e-02 5.6 5.7 1.2e-08 -0.05 0.02 0.82 FALSE
111 The Cancer Genome Atlas Thyroid Carcinoma MPST 0.08 0.09 lasso 5 0.06 1.4e-06 9.9 10.8 3.8e-27 0.68 0.30 0.70 FALSE
112 The Cancer Genome Atlas Thyroid Carcinoma POLR2F 0.02 0.02 blup 34 0.02 9.4e-03 6.0 5.8 8.4e-09 -0.04 0.01 0.74 FALSE
113 The Cancer Genome Atlas Thyroid Carcinoma TOMM22 0.06 0.04 lasso 3 0.04 1.1e-04 6.2 -6.5 5.7e-11 0.05 0.04 0.96 FALSE
114 The Cancer Genome Atlas Thyroid Carcinoma TST 0.05 0.04 lasso 2 0.04 9.9e-05 9.9 12.6 3.2e-36 0.81 0.00 0.95 TRUE
115 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma GCAT 0.17 0.05 blup 29 0.07 4.8e-03 5.7 -6.3 3.5e-10 0.01 0.03 0.37 FALSE
116 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma LOC646851 0.16 0.05 lasso 9 0.04 2.7e-02 5.7 6.3 2.9e-10 -0.01 0.01 0.47 FALSE