Hub : Genes

MICALL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.097	0.0310	9.6e-07	0.036	0.052	0.044	0.049	0.041	3.2e-05	6.2e-07	3.6e-06	1.2e-06	8.3e-06
2	GTEx	Artery Aorta	0.114	0.0450	2.1e-04	0.060	NA	-0.002	NA	0.025	3.1e-04	NA	4.3e-01	NA	1.6e-02
3	GTEx	Artery Tibial	0.110	0.0436	8.3e-05	0.038	NA	0.020	NA	0.050	6.0e-04	NA	9.7e-03	NA	8.4e-05
4	GTEx	Esophagus Mucosa	0.064	0.0310	4.6e-03	0.007	NA	0.004	NA	0.002	1.0e-01	NA	1.5e-01	NA	2.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.1	1.8	2.2	-1.4	1.2	1.2	1.5
Bipolar Disorder or Schizophrenia	0.3	0.7	1.9	-0.7	0.1	0.4	1.4
Depressed Affect (Nagel 2018)	0.8	1.7	3.4	-0.6	1.2	1.2	1.9
Depression (Nagel 2018)	0.1	0.2	0.3	-0.3	0.4	0.5	0.5
Intelligence (Savage-Jansen 2018)	5.0	15.4	17.0	3.6	-3.9	-4.1	-4.0
Neuroticism (Nagel 2018)	0.3	0.6	1.5	-0.2	0.6	0.7	1.2
Schizophrenia (2018)	0.2	0.3	0.7	0.2	-0.8	-0.5	0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.4	0.7	0.4	0.8
Worry (Nagel 2018)	0.3	0.6	0.8	-0.8	0.9	0.3	0.9
Alzheimer’s Disease (in mother)	3.8	4.4	6.6	1.9	-2.1	-1.7	-2.6
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.3	0.0	-0.0	-0.2
Alzheimer’s Disease (including proxy)	0.7	1.0	1.7	1.2	-0.7	-0.5	-1.3
Crohns Disease (2017)	0.3	0.6	1.3	-0.3	-1.0	-1.1	0.1
Irritable Bowel Disease (IBD)	0.9	2.1	4.7	-2.2	0.9	-0.0	1.7
Ulcerative Colitis (UC)	2.4	4.4	9.3	-3.0	2.0	0.8	2.0
Major Depression (MDD)	0.8	1.0	1.6	-0.8	1.1	1.3	0.7
Reaction Time	5.5	10.4	11.7	3.3	-2.9	-3.3	-3.4
Verbal and Numeric Reasoning (VNR)	3.3	8.0	11.2	2.2	-3.1	-3.4	-2.5
Breast Cancer	3.2	7.8	11.3	-1.1	3.4	3.0	3.1
Ovarian Cancer	1.3	1.7	2.3	1.5	-1.4	-1.2	-1.0
Prostate Cancer	2.1	2.9	4.2	1.2	-2.0	-2.0	-1.4
Age at First Birth	2.0	2.9	5.4	1.8	-1.4	-0.9	-2.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.9	-1.4	0.3	0.2	-0.1
Coronary Artery Disease (CAD)	0.3	0.3	0.9	-0.2	0.2	-0.6	0.9
Crohns Disease (2012)	0.5	0.8	1.9	0.7	-0.9	-1.4	0.2
Mean Putamen Volume	0.6	0.7	1.1	1.1	-0.9	-0.6	-0.7
Fasting Glucose	0.1	0.2	0.3	-0.4	0.1	-0.4	-0.5
HbA1C	1.1	1.2	1.8	1.3	-1.0	-1.0	-1.1
HDL Cholesterol	0.2	0.3	0.5	0.4	-0.5	-0.3	-0.7
LDL Cholesterol	3.7	5.9	7.6	1.6	-2.7	-2.8	-2.4
Lupus	0.1	0.2	0.3	-0.5	0.3	0.6	-0.3
Neuroticism (2016)	0.8	1.1	1.5	1.1	-1.1	-1.2	-0.9
Primary Biliary Cirrhosis	0.1	0.2	0.6	-0.4	0.2	0.1	0.8
Rheumatoid Arthritis	0.0	0.0	0.0	-0.1	-0.1	-0.2	-0.1
Schizophrenia (2014)	0.3	0.7	2.6	-0.4	0.1	-0.0	1.6
Triglycerides	0.1	0.2	0.4	-0.6	0.4	0.3	0.2
Type 2 Diabetes (T2D) (2012)	2.1	2.4	3.4	1.4	-1.9	-1.3	-1.6
Ulcerative Colitis	0.6	0.9	1.7	-1.3	1.0	-0.2	1.0
Blood Eosinophil Count	0.1	0.9	1.3	0.8	-1.1	-0.6	-1.1
Blood Platelet Count	2.6	30.6	39.1	-5.0	5.5	5.3	6.2
Blood Red Count	2.9	28.3	32.3	-5.5	5.7	5.7	4.3
Blood White Count	0.8	5.6	7.5	-1.7	2.5	2.7	2.5
Heel T-Score	5.3	42.0	50.1	-7.1	6.7	6.9	5.0
BMI	3.6	20.6	26.9	-4.8	4.4	5.2	3.7
Height	1.7	31.9	44.9	5.7	-6.0	-6.7	-3.8
Waist Hip Ratio (WHR)	0.1	0.4	1.3	0.1	1.2	0.3	0.5
Systolic Blood Pressure	2.0	10.2	14.2	-2.7	3.8	3.1	3.1
Smoking Status	5.1	12.3	14.3	3.8	-3.6	-2.8	-3.7
Allergy or Eczema	2.1	5.6	10.2	2.3	-1.8	-1.9	-3.2
Cardiovascular Disease	0.6	1.9	4.5	-0.2	1.5	1.0	2.1
Hypothyroidism (self reported)	0.7	1.7	2.6	1.3	-1.0	-1.1	-1.6
Respiratory disease	0.5	1.1	1.3	1.1	-1.1	-1.0	-1.0
Type 2 Diabetes (T2D) (2018)	2.1	3.9	5.6	2.4	-1.5	-1.7	-2.3
Lung FEV1/FVC ratio	1.2	6.0	8.6	-1.3	2.8	2.5	2.9
Lung FVC	1.6	8.3	13.0	1.9	-3.0	-2.8	-3.6
Neuroticism	0.1	0.3	0.7	0.1	0.4	0.9	0.6
Chronotype (morning person)	0.2	0.6	1.3	-1.1	-0.4	-0.5	0.7
Hair Pigment	0.1	1.8	4.7	0.5	-1.0	-1.2	-2.2
Tanning	0.9	10.9	13.5	3.5	-3.6	-3.7	-2.0
Hand grip strength (left)	1.4	3.6	4.3	-1.8	2.1	1.8	1.9
Number of treatments/medications taken	1.9	3.3	4.5	2.1	-1.8	-2.0	-1.2
Average weekly spirits intake	0.9	1.1	3.7	0.6	-0.5	-0.1	-1.9
Sensitivity / hurt feelings	0.7	1.2	3.5	-0.6	0.5	0.8	1.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.3
Hearing difficulty/problems: Yes	1.2	1.9	5.4	-0.3	1.2	0.8	2.3
Relative age of first facial hair	0.3	0.6	1.0	0.9	-1.0	-0.6	-0.6
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.3	1.5	-0.2	-0.3	-1.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	-0.4	0.5	0.7	0.6
Ever had hysterectomy (womb removed)	0.0	0.1	0.2	0.1	-0.1	-0.4	0.0
Systolic blood pressure, automated reading	1.9	5.4	7.9	-2.3	2.8	2.2	1.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.6	0.6	-0.8	-0.5	-0.8
Angina	0.1	0.1	0.3	0.4	-0.2	-0.5	0.1
Medication for hormone replacement therapy	0.3	0.4	0.9	0.2	1.0	0.6	0.4
Vitamin and mineral supplements	0.1	0.1	0.3	0.2	-0.4	-0.1	-0.6
Supplements: Zinc	0.2	0.2	0.4	-0.4	0.6	0.3	-0.2
Medication: Co-codamol	0.2	0.2	0.5	-0.1	-0.5	-0.5	0.7
Medication: Metformin	0.6	0.9	1.3	1.1	-0.7	-1.2	-0.8
Diabetes (father)	3.0	3.7	5.7	2.4	-2.2	-2.0	-0.7
Diabetes (mother)	1.3	1.7	2.9	-0.5	1.7	1.7	0.9
Severe depression (siblings)	0.1	0.1	0.3	-0.5	-0.3	-0.0	-0.4
Pack years adult smoking proportion	1.2	1.9	3.7	-1.0	1.2	1.1	1.9
Impedance of leg (right)	0.1	0.3	0.5	0.5	-0.7	-0.5	-0.7
Leg fat-free mass (left)	0.4	2.0	3.5	-1.3	1.3	1.1	1.9
Trunk fat percentage	2.3	9.3	13.0	-3.6	2.6	3.2	2.7
Hand grip strength (right)	1.9	5.2	8.8	-2.3	2.2	1.4	3.0
Townsend deprivation index at recruitment	0.1	0.2	0.5	0.3	-0.7	-0.4	-0.0
Current tobacco smoking	1.4	2.3	2.8	1.6	-1.7	-1.7	-0.8
Average weekly fortified wine intake	0.6	0.7	1.1	-0.8	0.9	0.5	-1.0
Maternal smoking around birth	2.2	3.2	4.8	1.5	-2.2	-1.6	-1.7
Fed-up feelings	0.4	0.8	2.1	-0.5	0.7	0.6	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	0.3	0.6	1.0	0.5
Relative age voice broke	0.3	0.5	1.2	-0.1	0.6	1.1	0.6
Taking other prescription medications	1.0	1.6	2.8	1.7	-0.9	-1.0	-1.3
Age when periods started (menarche)	2.9	7.1	10.9	2.5	-3.3	-2.8	-1.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.6	-0.2	-0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	5.1	11.5	15.1	-3.5	3.9	3.6	2.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.2	0.3	0.4	-0.4
Qualifications: CSEs or equivalent	0.3	0.4	0.6	0.6	-0.5	-0.5	-0.7
Serious illness, injury or assault to yourself	0.9	1.1	2.8	1.7	-0.9	-0.9	0.2
High blood pressure	0.3	1.0	3.6	0.1	0.3	-0.3	1.9
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.5	1.1	-0.7	-0.9	-1.9
Multivitamins +/- minerals	0.1	0.1	0.2	0.3	0.4	0.0	0.2
Stomach or abdominal pain in last month	0.2	0.3	0.8	0.5	0.2	0.9	-0.1
Supplements: Glucosamine	0.1	0.1	0.2	0.2	0.4	-0.2	0.5
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.0	-1.7	1.0	0.8	1.6
Medication: Atenolol	0.4	0.6	1.5	-0.0	-0.6	-0.7	-1.2
Medication: Levothyroxine sodium	1.8	3.1	6.3	1.4	-1.4	-1.5	-2.5
Sitting height	3.0	21.2	30.7	4.0	-5.1	-5.5	-3.4
Chronic bronchitis/emphysema (father)	0.8	0.9	2.5	0.4	-0.7	-0.7	-1.6
High blood pressure (mother)	0.2	0.2	0.8	0.9	0.1	-0.3	0.1
Body mass index (BMI)	2.6	11.3	13.3	-3.7	3.3	3.6	2.8
Impedance of leg (left)	0.2	1.0	1.8	0.9	-0.9	-0.8	-1.3
Leg predicted mass (left)	0.4	2.0	3.4	-1.3	1.3	1.1	1.8
Trunk fat mass	2.0	8.4	11.6	-3.4	2.5	2.9	2.7
Waist circumference	2.1	7.7	9.3	-3.1	2.7	2.7	2.6
Number of incorrect matches in round	5.1	8.6	10.1	-2.4	3.0	3.1	3.2
Past tobacco smoking	7.1	13.1	19.2	-3.4	3.7	2.9	4.4
Alcohol usually taken with meals	0.9	1.5	3.0	-1.5	0.6	0.6	1.7
Nervous feelings	0.1	0.3	0.5	-0.4	0.7	-0.1	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.3	-1.1	1.1	1.1	0.6
Hearing difficulty/problems with background noise	2.3	3.6	6.5	-1.0	2.0	1.8	2.5
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	-0.2	-0.6	-0.4	-0.8
Had menopause	1.8	2.2	3.2	0.9	-1.8	-1.3	-1.8
Had other major operations	1.0	1.2	1.8	1.2	-1.2	-0.4	-1.3
Forced vital capacity (FVC)	1.7	6.5	7.7	2.5	-2.4	-2.5	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	5.3	12.1	15.3	-3.8	3.9	3.7	2.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.4	-1.0	1.1	0.9	1.2
Qualifications: None of the above	0.9	1.8	2.5	-0.6	1.5	1.6	1.5
Financial difficulties in last 2 years	0.4	0.5	1.7	1.3	-0.5	-0.1	-0.2
Mouth/teeth dental problems	0.4	0.7	1.4	-1.2	0.9	0.6	0.3
Heart attack	0.1	0.1	0.2	0.5	-0.4	0.0	0.0
Allergy	0.2	0.5	1.1	-0.9	0.3	0.4	1.0
Pain all over the body in last month	0.3	0.3	0.9	0.2	-0.2	-0.3	-1.0
Diabetes (self-reported)	2.4	3.7	5.7	1.9	-1.6	-1.7	-2.4
Hayfever/allergic rhinitis (self-reported)	3.1	4.1	5.4	1.4	-2.3	-2.3	-2.0
Medication: Ramipril	0.5	0.7	2.0	0.2	0.3	-0.8	1.4
Medication: Simvastatin	0.4	0.6	1.7	-0.8	0.1	-0.2	1.3
Fluid intelligence score	3.4	7.1	8.1	2.8	-2.6	-2.8	-2.3
Illnesses of siblings	0.1	0.1	0.3	0.2	-0.5	-0.2	0.3
Neuroticism score	0.7	1.6	3.5	-0.7	1.1	1.0	1.9
Weight	0.8	3.9	5.0	-2.2	1.7	1.8	2.1
Impedance of arm (right)	0.2	0.7	1.2	0.8	-1.1	-0.8	-0.6
Arm fat percentage (right)	3.2	12.7	16.0	-4.0	3.3	3.8	3.1
Trunk fat-free mass	0.0	0.1	0.4	0.0	0.2	-0.2	0.6
Hip circumference	1.2	5.1	7.2	-2.7	1.9	2.1	2.2
Time employed in main current job	0.2	0.2	0.4	-0.3	0.5	0.2	0.6
Alcohol intake versus 10 years previously	1.9	2.8	4.1	-1.0	2.0	1.8	1.8
Father’s age at death	0.4	0.6	0.9	0.9	-0.7	-0.9	-0.4
Worrier / anxious feelings	0.5	0.9	2.9	-0.2	0.7	0.2	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.8	0.3	0.7	1.4	0.7
Falls in the last year	0.4	0.6	1.0	0.0	1.0	0.7	0.8
Hair/balding pattern: Pattern 3	0.9	1.3	1.8	0.4	-1.3	-1.3	-1.3
Number of live births	0.4	0.5	0.9	-0.1	-1.0	-0.5	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.1	1.8	-1.1	-1.2	-1.2
Pulse rate	3.7	6.2	10.4	-2.1	2.2	2.3	3.2
Happiness	0.5	0.6	1.4	1.2	-0.1	-0.8	0.4
Noisy workplace	2.4	2.9	3.4	-1.8	1.8	1.4	1.9
Qualifications: A levels/AS levels or equivalent	3.2	7.1	8.8	2.5	-2.7	-3.0	-2.4
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	4.6	1.9	-1.4	-1.5	-2.1
Mouth/teeth dental problems: Dentures	1.7	2.9	3.3	1.8	-1.8	-1.3	-1.8
Asthma	0.1	0.2	0.5	0.7	-0.4	-0.3	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.3	0.8	0.3	-0.4
Medication: Cholesterol lowering	0.1	0.1	0.2	0.4	-0.2	-0.3	0.2
Depression (self-reported)	0.5	0.6	1.0	0.5	-1.0	-1.0	-0.2
Medication: Lansoprazole	0.3	0.3	0.9	0.4	-0.5	-0.2	-1.0
Prospective memory result	1.2	1.5	2.6	-1.6	1.3	1.4	0.2
Lung cancer (father)	7.4	8.7	12.1	2.7	-3.5	-3.3	-2.2
Illnesses of mother	0.3	0.3	0.7	0.1	-0.8	-0.8	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	0.6	-0.3	-0.5	-0.7
Pulse wave Arterial Stiffness index	0.9	1.0	1.6	1.0	-1.2	-1.3	-0.3
Impedance of arm (left)	0.3	1.2	2.3	1.1	-1.5	-1.2	-0.5
Arm fat mass (right)	2.5	10.4	12.5	-3.5	3.1	3.4	2.8
Trunk predicted mass	0.0	0.2	0.5	-0.0	0.2	-0.2	0.7
Standing height	0.8	8.4	12.7	2.9	-3.1	-3.6	-1.7
Length of working week for main job	0.5	0.5	1.6	1.2	-0.7	-0.2	-0.2
Exposure to tobacco smoke at home	0.4	0.4	1.4	0.1	0.0	0.4	1.2
Breastfed as a baby	0.2	0.3	0.6	0.6	-0.1	-0.4	-0.8
Tense / ‘highly strung’	1.6	2.6	3.4	-1.8	1.4	1.5	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.6	-0.9	1.0	0.8	1.6
Hair/balding pattern: Pattern 4	1.4	3.4	4.6	2.1	-1.6	-1.8	-1.8
Birth weight of first child	0.3	0.5	1.8	-0.3	-0.1	0.4	1.4
Peak expiratory flow (PEF)	0.9	2.1	3.2	-0.2	1.5	1.8	1.7
Pulse wave reflection index	2.8	3.4	4.6	1.0	-2.0	-2.1	-2.0
Ever highly irritable/argumentative for 2 days	2.2	2.6	4.1	-1.2	2.0	2.0	1.0
Loud music exposure frequency	5.3	5.8	7.3	-2.3	2.7	2.6	1.9
Qualifications: O levels/GCSEs or equivalent	7.4	11.8	13.9	3.0	-3.2	-3.7	-3.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	0.9	0.7	-0.8	-1.0	-1.0
Blood clot in the leg (DVT)	0.6	0.7	1.0	-0.7	0.8	1.0	0.8
Medication: Paracetamol	0.3	0.4	0.7	-0.8	0.8	0.4	-0.4
Headache pain in last month	1.9	3.2	4.0	-1.2	2.0	2.0	1.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.3	0.1	0.5	-0.3
Glaucoma (self-reported)	2.0	2.3	4.8	-2.2	1.2	1.4	1.1
Gout (self-reported)	0.1	0.1	0.4	-0.1	0.1	0.7	-0.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	5.2	1.3	-1.3	-1.2	-2.3
Medication: Amlodipine	0.1	0.2	0.6	0.1	-0.3	-0.1	0.8
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	0.0	0.2	-0.0	0.1
Birth weight	0.1	0.2	0.5	-0.0	-0.5	0.1	-0.7
Chronic bronchitis/emphysema (mother)	2.6	3.0	4.4	1.6	-2.1	-1.7	-1.5
High blood pressure (siblings)	1.0	1.5	2.2	-1.5	1.4	1.1	0.5
Forced vital capacity (FVC), Best measure	0.9	3.3	3.7	1.6	-1.7	-1.9	-1.9
Body fat percentage	3.2	12.8	17.2	-4.2	3.2	3.8	3.0
Leg fat percentage (right)	4.2	15.1	19.7	-4.4	3.6	4.1	3.3
Arm fat-free mass (right)	0.1	0.7	1.3	-0.8	0.7	0.6	1.2
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.0	-0.5	-0.2	-0.5
Comparative body size at age 10	0.1	0.3	0.5	0.7	-0.4	-0.0	-0.7
Number of full brothers	1.3	1.6	3.7	-0.6	-1.2	-1.9	-1.1
Worry too long after embarrassment	0.4	0.7	1.2	1.1	-0.7	-0.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.1	-1.0	0.8	0.9	0.5
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	0.4	-1.0	-0.6	-0.3
Number of children fathered	0.4	0.5	0.7	-0.7	0.6	0.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	3.2	-1.4	1.8	1.8	1.3
Age at first live birth	0.3	0.5	1.4	0.3	-0.4	-0.5	-1.2
Pulse wave peak to peak time	0.5	0.5	1.0	-0.6	0.9	1.0	0.1
Health satisfaction	0.2	0.2	0.5	0.5	0.4	-0.2	0.7
Shortness of breath walking on level ground	0.2	0.3	0.5	-0.7	-0.4	-0.6	0.3
Qualifications: College or University degree	0.8	2.6	3.6	1.8	-1.7	-1.9	-0.9
Eye problems/disorders: None of the above	0.3	0.4	0.7	-0.8	0.6	0.1	0.7
Mouth/teeth dental problems: Loose teeth	2.8	3.4	4.3	2.0	-1.6	-1.6	-2.1
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.4	-0.2	-0.2	-0.7
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	0.9	-1.3	-0.7	-0.3
Neck or shoulder pain in last month	0.3	0.4	0.9	1.0	-0.5	-0.5	-0.3
Medication: Blood pressure	0.1	0.2	0.7	-0.1	0.2	0.0	0.8
Angina (self-reported)	0.0	0.0	0.1	0.1	0.1	-0.3	0.2
Migraine (self-reported)	0.1	0.2	0.5	-0.1	-0.3	-0.2	-0.7
Medication: Ibuprofen	0.3	0.3	0.7	0.7	0.4	0.1	-0.8
Medication: Allopurinol	0.2	0.3	0.8	-0.4	0.5	0.9	0.1
Medication: Omeprazole	0.3	0.4	0.7	0.3	-0.4	-0.7	-0.9
Medication: Seretide 50 evohaler	0.7	0.8	3.1	0.2	0.4	0.3	1.8
Mean time to correctly identify matches	6.0	11.4	13.6	2.9	-3.5	-3.7	-3.4
Heart disease (mother)	0.1	0.1	0.3	0.6	0.0	0.1	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.4	4.8	1.0	-1.4	-1.4	-2.2
Whole body fat mass	2.7	11.2	14.5	-3.8	3.0	3.5	3.0
Leg fat mass (right)	3.6	13.8	17.5	-4.2	3.5	3.8	3.3
Arm predicted mass (right)	0.1	0.7	1.4	-0.7	0.8	0.7	1.2
Pulse rate, automated reading	2.1	6.8	8.0	-2.4	2.7	2.4	2.8
Alcohol intake frequency.	0.2	0.4	0.9	-0.3	0.7	0.3	0.9
Comparative height size at age 10	0.1	0.5	1.7	0.4	0.2	-0.4	1.3
Number of full sisters	0.5	0.6	0.8	-0.9	0.7	0.7	0.7
Suffer from ‘nerves’	0.1	0.2	0.7	-0.0	-0.2	-0.8	0.1
Overall health rating	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.2
Chest pain or discomfort	0.0	0.0	0.1	-0.3	0.1	-0.0	-0.1
Had major operations	0.4	0.4	0.9	0.9	-0.4	-0.8	0.1
Age at last live birth	0.2	0.3	0.7	-0.2	0.9	0.5	-0.1
Family relationship satisfaction	0.1	0.2	0.3	0.0	-0.3	-0.5	-0.5
Leg pain on walking	0.1	0.1	0.4	0.6	0.2	0.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.6	0.1	-0.1	-0.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	5.2	0.4	-0.6	-0.3	-2.3
Illness, injury, bereavement, stress in last 2 years	3.4	4.2	9.0	-3.0	1.5	1.6	1.6
Medication: Aspirin	1.1	1.4	2.7	-1.0	1.6	0.9	1.1
Supplements: Vitamin C	0.2	0.2	0.7	-0.3	0.4	-0.1	0.8
Knee pain experienced in last month	0.1	0.2	0.7	0.8	0.3	-0.1	-0.1
Hypertension (Self-reported)	0.2	0.5	1.8	0.2	0.0	-0.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.6	-0.8	0.8	0.6	0.8
Illnesses of father: Heart disease	1.3	1.8	2.4	1.0	-1.4	-1.3	-1.5
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.2	0.4	-0.1	-0.4
Smoking status: Previous	5.9	8.8	16.2	2.9	-2.7	-1.9	-4.0
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.2	5.3	1.3	-1.7	-1.8	-2.3
Whole body fat-free mass	0.1	0.5	1.2	-0.6	0.7	0.3	1.1
Leg fat-free mass (right)	0.2	1.0	1.7	-0.9	0.9	0.7	1.3
Arm fat percentage (left)	3.4	13.6	16.2	-4.0	3.4	3.9	3.5
Average weekly red wine intake	1.0	1.4	1.9	-1.4	1.0	1.3	1.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	-1.0	0.5	0.3	0.5
Mood swings	1.3	2.3	3.4	-1.1	1.7	1.4	1.8
Loneliness, isolation	0.5	0.7	2.1	-0.2	0.8	0.3	1.4
Long-standing illness, disability or infirmity	3.1	4.7	7.8	2.8	-1.5	-1.5	-2.5
Ever had bowel cancer screening	0.6	0.7	2.0	0.3	-0.7	-0.5	-1.4
Diabetes diagnosed by doctor	2.0	3.3	4.7	1.8	-1.6	-1.7	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.1	-0.5	1.5	1.2	0.8
Friendships satisfaction	0.0	0.1	0.2	0.5	0.1	0.1	-0.1
Qualifications: nursing, teaching	0.4	0.5	1.3	-0.1	-0.6	-0.7	-1.2
Commuting to job workplace: Walk	0.3	0.4	0.6	-0.4	0.4	0.8	0.8
Eye problems/disorders: Cataract	0.4	0.5	0.7	0.4	0.8	0.7	0.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	4.5	-1.2	1.9	1.6	2.1
Medication for cholesterol	0.5	0.7	1.5	-0.0	0.3	1.2	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.4	-0.3	0.3	-0.8
Back pain experienced in last month	0.4	0.7	2.0	1.4	-0.2	0.3	-0.7
Mineral and other dietary supplements	0.3	0.4	0.9	-0.9	0.0	0.2	0.9
Breast cancer (self-reported)	1.4	1.7	4.7	0.9	-1.1	-0.3	-2.2
Asthma (self-reported)	0.1	0.2	0.4	0.6	-0.4	-0.3	-0.4
Osteoporosis (self-reported)	1.3	1.6	2.0	1.3	-1.4	-1.0	-1.2
Osteoarthritis (self-reported)	0.5	0.7	2.3	0.5	-0.2	-0.2	-1.5
Medication: Aspirin	0.4	0.5	1.1	-0.2	1.0	0.5	0.7
Medication: Gliclazide	1.9	2.2	4.8	1.1	-1.0	-1.3	-2.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.9	-0.8	1.0	0.4	1.4
Smoking status: Current	0.9	1.5	2.2	1.2	-1.5	-1.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	0.3	0.2	0.2	0.4
Whole body water mass	0.1	0.5	1.2	-0.6	0.7	0.4	1.1
Leg predicted mass (right)	0.2	0.8	1.5	-0.8	0.8	0.7	1.2
Arm fat mass (left)	2.3	9.4	11.4	-3.4	2.9	3.2	2.8
Number of self-reported non-cancer illnesses	0.5	0.9	1.7	0.9	-1.0	-1.3	-0.2
Average weekly champagne plus white wine intake	0.8	1.1	1.5	-1.2	1.1	0.5	1.1
Miserableness	0.9	1.5	4.4	0.2	1.0	0.8	2.1
Guilty feelings	0.0	0.0	0.0	0.1	-0.0	0.2	-0.2
Wears glasses or contact lenses	0.4	0.4	1.0	-0.5	-0.3	-0.7	1.0
Ever taken oral contraceptive pill	1.9	2.1	5.3	0.9	-1.1	-1.1	-2.3
Hearing aid user	0.4	0.5	1.0	0.7	0.3	-0.4	1.0
Mother’s age at death	1.3	1.6	2.2	1.4	-0.9	-1.3	-1.5
Financial situation satisfaction	0.7	0.9	2.2	-0.1	-0.7	-0.8	-1.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.4	-1.2	-0.3	-0.9	0.8
Commuting to job workplace: Public transport	0.6	0.7	2.0	-0.4	0.8	0.4	1.4
Eye problems/disorders: Glaucoma	3.9	4.7	7.8	-2.8	1.9	2.1	1.7
Medication: Blood pressure	1.1	2.0	4.2	1.1	-1.6	-2.0	0.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.2	1.8	-0.4	-0.5	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	0.6	0.6	0.9	-0.5
High cholesterol (Self-reported)	0.1	0.2	0.4	-0.1	-0.3	-0.6	0.5
Medication: Bendroflumethiazide	0.8	1.3	3.5	0.2	-1.2	-1.9	-0.3
Medication: Paracetamol	0.3	0.4	0.8	-0.4	0.9	0.7	-0.4
Medication: Lisinopril	0.5	0.6	2.2	-0.2	0.4	0.2	1.5
Medication: Atorvastatin	0.0	0.1	0.2	-0.1	0.2	-0.1	0.4
Illnesses of father: High blood pressure	0.6	0.7	2.3	-0.6	0.1	0.4	1.5
Alcohol drinker status: Never	0.6	0.8	1.6	-0.0	0.9	0.8	1.3
Ever smoked	5.1	8.9	11.4	2.8	-3.1	-2.6	-3.4
Basal metabolic rate	0.2	1.2	2.1	-1.0	1.1	0.8	1.4
Leg fat percentage (left)	3.3	12.0	15.9	-4.0	3.2	3.7	2.8
Arm fat-free mass (left)	0.1	0.3	0.6	-0.5	0.6	0.3	0.8
Number of operations (self-reported)	0.1	0.1	0.2	0.5	-0.2	0.3	0.2
Average weekly beer plus cider intake	1.8	2.7	5.7	1.1	-1.5	-1.3	-2.4
Irritability	1.2	2.0	4.0	-0.2	1.3	2.0	1.4
Risk taking	0.2	0.3	0.5	-0.7	-0.4	-0.7	0.1
Ever had prostate specific antigen (PSA) test	1.5	1.7	4.5	-0.6	1.4	0.3	2.1
Fractured/broken bones in last 5 years	0.8	1.0	3.0	-0.5	0.8	0.3	1.7
Age started oral contraceptive pill	0.3	0.4	1.2	0.0	-0.3	0.3	-1.1
Diastolic blood pressure, automated reading	1.3	3.9	5.5	-2.1	2.3	1.9	1.5
Ever depressed for a whole week	0.3	0.3	1.0	-0.3	0.3	-0.2	1.0
Unable to work because of sickness or disability	0.3	0.3	0.7	-0.1	-0.8	-0.4	-0.7
Commuting to job workplace: Cycle	0.4	0.5	1.5	1.2	-0.3	-0.4	-0.4
Myopia	0.8	1.2	2.3	-0.7	1.5	0.9	1.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.0	0.1	-0.3	0.1	-1.7
Cholesterol lowering medication	0.4	0.5	1.0	-0.6	-0.3	-0.9	1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	0.1	-0.6	-0.7	-1.1
Pain experienced in last month	0.2	0.4	0.5	-0.7	-0.5	-0.6	-0.6
Supplements: Calcium	0.7	0.7	1.2	0.9	-1.1	-0.9	-0.3
Basal cell carcinoma (self-reported)	1.1	1.3	2.0	-1.1	1.4	0.5	1.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.6	-0.6	-0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.0	-0.8	1.2	1.4	0.9
Heart disease (siblings)	0.1	0.1	0.5	0.7	0.1	-0.1	-0.1
Alcohol drinker status: Previous	0.3	0.3	0.9	-0.1	-0.4	-1.0	-0.4
Pack years of smoking	1.6	2.3	4.5	-1.3	1.4	1.1	2.1
Impedance of whole body	0.3	1.5	2.4	1.0	-1.5	-1.3	-1.1
Leg fat mass (left)	2.9	11.4	14.0	-3.7	3.1	3.6	3.0
Arm predicted mass (left)	0.1	0.5	0.7	-0.6	0.8	0.6	0.9