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chr22:41,232,594-44,282,307

Best TWAS P=2.17e-79 · Best GWAS P=6.49e-80 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	GTEx	Cells EBV-transformed lymphocytes	PACSIN2	0.25	0.17	enet	15	0.11	1.7e-04	18.78	-18.9	2.2e-79	-0.89	0.03	0.95	TRUE
7	GTEx	Adipose Subcutaneous	ARFGAP3	0.07	0.07	enet	7	0.05	3.5e-05	-16.67	-17.7	9.3e-70	-0.83	0.37	0.62	TRUE
52	YFS	Blood	PACSIN2	0.06	0.07	enet	20	0.08	8.9e-26	18.78	-17.4	4.4e-68	-0.95	0.02	0.98	TRUE
43	GTEx	Spleen	PACSIN2	0.37	0.11	lasso	13	0.11	9.0e-04	17.80	17.1	2.7e-65	0.91	0.07	0.75	TRUE
10	GTEx	Adipose Visceral Omentum	ARFGAP3	0.12	0.11	enet	18	0.09	1.4e-05	-16.86	-14.9	5.0e-50	-0.75	0.70	0.27	TRUE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARFGAP3	0.06	0.07	blup	74	0.07	5.4e-08	-16.13	-12.9	4.8e-38	-0.58	0.80	0.19	TRUE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	A4GALT	0.04	0.01	blup	66	0.02	1.5e-03	1.99	8.3	7.1e-17	0.12	0.01	0.69	TRUE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	A4GALT	0.07	0.03	blup	66	0.04	3.8e-05	-1.18	-8.3	8.8e-17	0.05	0.04	0.11	TRUE
39	GTEx	Skin Sun Exposed Lower leg	SERHL2	0.11	0.04	enet	17	0.06	8.6e-06	-2.29	-6.9	6.4e-12	-0.35	0.54	0.19	TRUE
6	GTEx	Adipose Subcutaneous	A4GALT	0.18	0.05	enet	35	0.15	4.1e-12	-1.18	6.6	5.2e-11	-0.11	0.58	0.02	TRUE
42	GTEx	Spleen	CYB5R3	0.33	0.01	enet	26	0.14	2.3e-04	3.40	6.5	7.5e-11	0.06	0.07	0.06	TRUE
1	CommonMind	Brain Pre-frontal Cortex	A4GALT	0.20	0.04	enet	33	0.13	2.9e-15	0.46	6.4	1.2e-10	0.11	1.00	0.00	TRUE
72	The Cancer Genome Atlas	Thyroid Carcinoma	BIK	0.11	0.07	lasso	5	0.08	2.8e-08	-6.10	6.3	3.4e-10	0.05	0.99	0.00	TRUE
9	GTEx	Adipose Visceral Omentum	RRP7A	0.46	0.07	enet	36	0.15	3.4e-08	1.54	6.0	2.2e-09	0.15	0.90	0.01	TRUE
51	YFS	Blood	A4GALT	0.30	0.21	bslmm	477	0.22	1.5e-68	6.16	5.9	4.4e-09	-0.12	1.00	0.00	TRUE
14	GTEx	Artery Tibial	FAM109B	0.16	0.08	enet	32	0.10	4.9e-08	-4.00	5.8	7.2e-09	-0.03	0.97	0.00	TRUE
17	GTEx	Brain Cerebellar Hemisphere	SMDT1	0.63	0.38	enet	28	0.44	8.8e-13	-4.07	5.7	1.1e-08	-0.01	0.98	0.01	TRUE
16	GTEx	Brain Caudate basal ganglia	CSDC2	0.13	0.03	enet	9	0.08	2.0e-03	-3.99	-5.7	1.2e-08	0.01	0.07	0.66	TRUE
30	GTEx	Lung	A4GALT	0.17	0.01	enet	18	0.03	1.5e-03	3.45	5.7	1.2e-08	0.00	0.28	0.04	TRUE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTLL12	0.16	0.00	blup	81	0.04	1.6e-03	2.62	5.3	1.1e-07	-0.05	0.02	0.04	TRUE
58	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ACO2	0.03	0.01	blup	41	0.04	3.9e-03	4.17	-5.3	1.2e-07	-0.08	0.02	0.52	TRUE
34	GTEx	Ovary	RRP7A	0.62	0.04	lasso	9	0.06	1.4e-02	-1.54	-5.2	2.3e-07	-0.28	0.04	0.08	TRUE
3	CommonMind	Brain Pre-frontal Cortex	PACSIN2	0.07	0.05	lasso	3	0.04	7.7e-06	16.91	-18.5	3.5e-76	-0.96	0.03	0.97	FALSE
36	GTEx	Prostate	RN7SKP80	0.19	0.22	lasso	4	0.23	2.1e-06	18.80	18.4	1.0e-75	0.95	0.04	0.80	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARFGAP3	0.05	0.05	lasso	5	0.06	6.5e-12	-16.82	-17.1	1.0e-65	-0.85	0.04	0.96	FALSE
49	GTEx	Whole Blood	ARFGAP3	0.07	0.10	enet	6	0.09	4.7e-09	-16.88	16.9	5.0e-64	0.80	1.00	0.00	FALSE
47	GTEx	Thyroid	ARFGAP3	0.20	0.21	lasso	5	0.22	1.1e-16	-16.17	-16.8	1.9e-63	-0.78	1.00	0.00	FALSE
25	GTEx	Breast Mammary Tissue (Female)	ARFGAP3	0.18	0.11	lasso	6	0.05	1.2e-02	-15.87	-16.8	4.7e-63	-0.79	0.09	0.44	FALSE
69	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ARFGAP3	0.12	0.09	lasso	5	0.05	8.7e-03	-16.88	-16.7	9.7e-63	-0.79	0.09	0.20	FALSE
64	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ARFGAP3	0.06	0.04	lasso	4	0.04	7.1e-06	-16.14	-16.5	3.1e-61	-0.75	0.84	0.16	FALSE
41	GTEx	Skin Sun Exposed Lower leg	ARFGAP3	0.09	0.04	lasso	5	0.04	2.7e-04	-16.31	-16.5	3.7e-61	-0.76	0.47	0.51	FALSE
33	GTEx	Ovary	PACSIN2	0.25	0.16	lasso	7	0.11	1.2e-03	-16.67	-16.4	4.1e-60	-0.74	0.10	0.43	FALSE
24	GTEx	Breast Mammary Tissue	ARFGAP3	0.15	0.12	lasso	2	0.08	9.7e-05	-16.20	-16.2	4.9e-59	-0.74	0.82	0.13	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	ARFGAP3	0.12	0.12	lasso	3	0.12	2.5e-11	-16.14	-16.2	4.9e-59	-0.75	0.99	0.01	FALSE
12	GTEx	Artery Aorta	PACSIN2	0.10	0.07	lasso	1	0.04	1.7e-03	-16.17	-16.2	8.8e-59	-0.74	0.41	0.50	FALSE
29	GTEx	Esophagus Mucosa	ARFGAP3	0.12	0.10	lasso	4	0.07	1.2e-05	-15.87	-15.7	9.3e-56	-0.75	0.93	0.06	FALSE
15	GTEx	Artery Tibial	ARFGAP3	0.07	0.05	enet	11	0.04	2.2e-04	-16.86	-15.1	2.6e-51	-0.77	0.38	0.48	FALSE
27	GTEx	Colon Sigmoid	ARFGAP3	0.16	-0.01	lasso	5	0.00	3.9e-01	18.77	-14.0	2.2e-44	-0.80	0.05	0.72	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ARFGAP3	0.05	0.00	blup	74	0.01	3.7e-02	17.82	-13.6	6.6e-42	-0.64	0.01	0.74	FALSE
31	GTEx	Lung	ARFGAP3	0.12	0.01	lasso	3	0.03	3.8e-03	-16.82	-13.1	2.9e-39	-0.58	0.14	0.54	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	ARFGAP3	0.11	0.00	enet	8	0.01	9.4e-02	-16.14	-12.7	3.8e-37	-0.71	0.09	0.50	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARFGAP3	0.11	0.06	blup	550	0.05	1.1e-06	-16.20	-11.3	8.5e-30	-0.58	0.98	0.02	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TTLL1	0.13	0.08	lasso	3	0.12	5.3e-14	-7.49	-10.5	9.1e-26	-0.53	1.00	0.00	FALSE
19	GTEx	Brain Cortex	TTLL1	0.23	0.28	lasso	2	0.24	2.6e-07	-10.11	10.1	6.6e-24	0.52	0.48	0.17	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	ARFGAP3	0.11	0.06	enet	21	0.08	2.0e-09	-16.22	-10.0	1.3e-23	-0.62	0.33	0.67	FALSE
66	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ARFGAP3	0.21	0.03	enet	26	0.05	2.2e-04	-8.97	-9.7	2.7e-22	-0.52	0.11	0.48	FALSE
50	NTR	Blood	PACSIN2	0.02	0.00	bslmm	595	0.01	1.5e-03	-16.70	9.6	5.4e-22	0.38	0.79	0.01	FALSE
32	GTEx	Muscle Skeletal	ARFGAP3	0.07	0.03	lasso	4	0.04	1.1e-04	-2.11	-9.3	1.6e-20	-0.49	0.52	0.10	FALSE
40	GTEx	Skin Sun Exposed Lower leg	RN7SKP80	0.12	0.00	enet	45	0.01	2.3e-02	-2.20	-9.2	2.4e-20	-0.46	0.05	0.66	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	TTLL12	0.29	-0.01	lasso	7	0.02	8.3e-02	-6.29	-8.7	3.0e-18	-0.63	0.05	0.39	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TTLL1	0.05	0.00	blup	75	0.01	1.7e-02	18.80	7.6	2.1e-14	0.59	0.01	0.29	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	A4GALT	0.03	0.01	enet	12	0.03	2.8e-06	2.99	7.2	4.5e-13	0.33	0.02	0.68	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTLL1	0.12	0.11	lasso	3	0.12	3.6e-13	-3.80	7.1	1.7e-12	0.45	1.00	0.00	FALSE
8	GTEx	Adipose Visceral Omentum	PACSIN2	0.14	0.01	enet	36	0.02	4.9e-02	17.82	-7.0	2.8e-12	-0.55	0.06	0.72	FALSE
46	GTEx	Testis	RRP7B	0.19	0.02	enet	35	0.04	4.6e-03	7.03	-7.0	3.0e-12	-0.23	0.12	0.04	FALSE
48	GTEx	Whole Blood	A4GALT	0.20	0.07	enet	7	0.05	3.5e-05	6.16	6.5	6.2e-11	-0.11	0.98	0.00	FALSE
45	GTEx	Testis	A4GALT	0.31	0.16	lasso	4	0.27	3.2e-12	7.95	6.5	7.6e-11	0.13	1.00	0.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	RRP7B	0.18	0.04	enet	25	0.12	4.2e-10	-2.29	-6.2	6.0e-10	-0.30	0.88	0.05	FALSE
35	GTEx	Prostate	SERHL2	0.22	0.08	enet	33	0.03	7.7e-02	-3.29	6.1	1.1e-09	0.37	0.05	0.22	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	BIK	0.01	0.00	blup	72	0.01	1.1e-02	-7.49	6.1	1.1e-09	0.38	0.01	0.55	FALSE
11	GTEx	Adrenal Gland	RRP7A	0.39	0.05	enet	22	0.19	3.0e-07	-1.45	5.8	6.2e-09	0.21	0.24	0.18	FALSE
5	CommonMind	Brain Pre-frontal Cortex	TTLL12	0.43	0.15	lasso	12	0.27	1.9e-33	5.31	5.7	9.5e-09	0.01	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MCAT	0.15	0.09	lasso	2	0.11	6.6e-07	-6.29	5.5	4.1e-08	0.04	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PHF5A	0.03	0.00	blup	30	0.01	2.9e-02	-4.91	-5.5	5.1e-08	-0.09	0.01	0.51	FALSE
70	The Cancer Genome Atlas	Testicular Germ Cell Tumors	POLR3H	0.10	0.02	blup	23	0.06	3.4e-03	-5.32	5.4	7.4e-08	0.08	0.01	0.78	FALSE
18	GTEx	Brain Cerebellum	SLC25A5P1	0.24	0.11	enet	16	0.14	7.3e-05	3.84	-5.3	9.6e-08	-0.10	0.35	0.05	FALSE
28	GTEx	Esophagus Mucosa	A4GALT	0.25	0.10	enet	61	0.13	6.8e-09	0.20	5.3	1.1e-07	-0.11	0.99	0.00	FALSE
13	GTEx	Artery Coronary	CYP2D8P1	0.13	0.01	lasso	3	0.04	1.3e-02	-4.17	5.2	1.5e-07	-0.05	0.14	0.08	FALSE
20	GTEx	Brain Frontal Cortex BA9	TTLL12	0.34	0.06	enet	21	0.10	1.6e-03	5.31	-5.2	1.6e-07	-0.49	0.06	0.40	FALSE
23	GTEx	Brain Putamen basal ganglia	POLR3H	0.23	0.06	enet	20	0.04	4.5e-02	-5.13	-5.2	2.3e-07	-0.07	0.05	0.56	FALSE
44	GTEx	Stomach	DESI1	0.12	0.07	enet	14	0.06	4.9e-04	-5.17	-5.2	2.3e-07	-0.07	0.07	0.92	FALSE
21	GTEx	Brain Frontal Cortex BA9	POLR3H	0.13	0.09	lasso	7	0.04	3.4e-02	-5.17	-5.2	2.7e-07	-0.09	0.04	0.79	FALSE