TWAS hub - TST

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1300	0.0340	2.2e-05	0.112	0.064	0.111	0.096	0.111	1.6e-13	3.2e-08	2.2e-13	9.3e-12	2.0e-13
2	GTEx	Adipose Visceral Omentum	0.2190	0.0660	1.7e-03	0.013	NA	0.002	NA	0.006	7.0e-02	NA	2.3e-01	NA	1.5e-01
3	GTEx	Brain Cerebellar Hemisphere	0.3480	0.1190	8.5e-03	0.004	NA	0.001	NA	0.026	2.4e-01	NA	3.0e-01	NA	7.3e-02
4	YFS	Blood	0.0593	0.0140	1.4e-08	0.024	0.028	0.028	0.030	0.028	2.4e-08	1.7e-09	1.1e-09	3.6e-10	1.1e-09
5	TCGA	Brain Lower Grade Glioma	0.0677	0.0321	2.0e-03	-0.002	0.028	0.027	NA	-0.001	8.8e-01	3.8e-04	3.8e-04	NA	4.9e-01
6	TCGA	Thyroid Carcinoma	0.0470	0.0270	5.5e-03	0.040	0.022	0.031	NA	0.039	9.0e-05	2.8e-03	4.8e-04	NA	9.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
HbA1C	8.5	9.4	44.6	-1.9	0.9	-1.6	-1.9	1.2	6.7
Sensitivity / hurt feelings	4.2	7.2	17.9	-2.5	-1.2	-2.9	-1.8	2.4	4.2
Hayfever/allergic rhinitis (self-reported)	3.3	4.4	12.0	-1.9	-0.3	-2.9	-3.5	-0.1	1.6
Blood Platelet Count	3.2	37.7	158.8	-5.4	-0.9	-1.9	-2.2	5.4	12.6
Supplements: Glucosamine	3.2	4.1	12.0	2.7	0.5	1.6	1.3	-1.1	-3.5
Blood Red Count	2.9	28.4	90.1	-7.4	-4.1	-3.0	-0.4	0.5	9.5
Neuroticism score	2.2	4.6	14.9	-2.2	-0.3	-1.9	-1.0	1.8	3.9
Wheeze or whistling in the chest in last year	2.2	3.9	10.4	-1.4	-3.2	-1.6	-2.0	-1.3	1.8
Leg pain on walking	2.1	2.7	5.4	2.3	-0.1	2.2	0.8	0.8	-2.1
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	9.3	-0.1	0.7	0.7	-3.0	-2.2	-0.4
Pain all over the body in last month	2.0	2.2	4.4	-2.1	-1.5	-1.3	-1.1	-1.6	0.8
Worry too long after embarrassment	2.0	3.3	6.9	-2.3	-1.1	-1.1	-1.1	2.0	2.6
Average weekly beer plus cider intake	2.0	2.8	4.9	-2.2	-2.2	-1.7	-0.7	-0.4	1.9
Lupus	1.9	2.9	9.7	-1.7	-1.3	-1.5	-3.1	-0.6	0.8
Neuroticism	1.9	4.5	11.3	-2.6	0.0	-2.5	-1.6	0.4	3.4
Medication: Lansoprazole	1.9	2.1	7.9	-0.5	0.8	-1.3	-1.3	0.7	2.8
Myopia	1.9	2.7	7.4	-0.7	2.2	-2.7	-1.9	-0.2	0.4
Coronary Artery Disease (CAD)	1.8	2.2	4.4	-2.1	0.0	-2.1	-1.9	-0.9	0.0
Ulcerative Colitis	1.8	2.7	6.9	-1.8	-1.2	-1.8	0.9	-2.6	-0.4
Medication for hormone replacement therapy	1.8	2.1	7.6	0.5	2.8	-0.8	0.6	-1.8	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	5.5	-2.3	-2.1	-0.8	-1.1	-0.3	0.9
Mean Putamen Volume	1.7	2.0	6.0	1.0	-1.5	0.6	0.9	-1.1	-2.4
Medication: Omeprazole	1.7	2.0	6.8	-2.6	-1.1	-0.4	-1.7	-0.2	1.0
Type 2 Diabetes (T2D) (2012)	1.6	1.9	4.8	1.8	-1.5	0.1	2.2	0.1	-1.0
Average weekly fortified wine intake	1.6	1.9	4.9	1.3	0.5	1.6	1.2	-0.6	-2.2
Maternal smoking around birth	1.6	2.3	4.5	-2.1	-2.1	-1.0	-0.6	-1.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	4.9	-1.4	-1.1	-2.1	-0.2	0.5	2.2
Loneliness, isolation	1.6	2.2	5.4	-0.6	-1.3	-0.7	-0.7	2.3	2.2
Ever taken oral contraceptive pill	1.6	1.7	6.5	-2.5	-1.2	-0.9	-0.7	-0.1	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	5.8	0.3	0.1	-0.0	1.5	2.4	1.5
Blood clot in the leg (DVT)	1.5	2.0	5.0	-1.1	-1.4	-1.8	-0.1	-2.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	4.7	1.6	0.3	0.8	-0.4	1.5	2.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.3	1.8	0.5	1.0	1.5	1.3	-0.9
Noisy workplace	1.4	1.7	3.8	2.0	0.4	1.8	0.5	1.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	5.0	-0.4	-2.2	-1.7	0.5	1.2	1.7
Had major operations	1.4	1.6	3.3	-1.8	-1.7	-1.4	-1.2	-0.2	0.4
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.7	0.7	1.1	2.2	-1.6	-0.7	-0.4
Miserableness	1.4	2.3	8.7	-0.7	0.1	-1.5	-0.7	1.5	2.9
Respiratory disease	1.3	2.9	8.3	0.3	-2.6	1.3	-2.9	0.0	-0.2
Ever had hysterectomy (womb removed)	1.3	1.4	4.7	0.3	-0.6	2.2	0.5	1.5	1.0
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	5.8	0.1	-0.7	0.5	0.2	-2.4	-1.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	7.7	0.0	0.4	-1.1	0.0	0.8	2.8
Number of full brothers	1.3	1.6	5.1	-1.1	-1.2	-0.9	0.3	1.0	2.3
Emphysema/chronic bronchitis	1.3	1.4	2.9	1.6	-1.7	0.2	-1.2	1.1	-0.4
Migraine (self-reported)	1.3	1.6	5.6	0.0	-0.4	-0.4	0.1	-2.4	-1.9
Medication: Seretide 50 evohaler	1.3	1.5	3.6	0.3	-1.9	1.0	1.9	-0.8	-0.4
Friendships satisfaction	1.3	1.6	3.5	-1.2	-1.6	-0.9	-0.0	1.1	1.9
Asthma (self-reported)	1.3	2.5	5.9	0.2	-2.4	1.8	-2.3	-0.7	0.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.9	-2.0	0.9	-0.7	-1.2	-0.2	1.5
Age started oral contraceptive pill	1.3	1.6	3.9	1.4	1.7	2.0	0.5	-0.4	-0.8
Depression (Nagel 2018)	1.2	1.8	4.0	-1.6	-1.5	-1.2	-0.5	-0.4	2.0
Breast Cancer	1.2	2.8	9.1	1.5	1.3	3.0	1.5	1.2	0.1
Diabetes (father)	1.2	1.5	3.3	1.8	0.8	1.1	0.7	-1.0	-1.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	3.4	-1.4	-0.9	-1.3	0.2	-0.3	1.8
Medication: Atenolol	1.2	1.5	4.4	-0.4	2.1	0.5	-0.4	-2.0	-0.2
Heart attack	1.2	1.5	4.4	-0.9	-1.0	-0.6	0.1	1.5	2.1
Time employed in main current job	1.2	1.4	5.3	0.6	1.1	0.3	-0.2	-1.1	-2.3
Alcohol intake versus 10 years previously	1.2	1.8	6.7	-0.7	-0.6	-1.6	-2.6	-0.9	0.4
Worrier / anxious feelings	1.2	2.3	8.3	-1.9	-0.0	-0.8	-0.2	1.1	2.9
Asthma	1.2	2.3	5.5	0.0	-2.3	1.6	-2.3	-0.7	0.1
Neck or shoulder pain in last month	1.2	1.8	8.1	-0.3	-2.8	-1.2	-0.3	-0.9	-0.1
Chest pain or discomfort	1.2	1.8	5.5	0.8	-0.0	0.4	1.3	1.7	2.3
Family relationship satisfaction	1.2	1.5	3.2	-0.1	-1.7	0.8	-0.1	1.5	1.8
Guilty feelings	1.2	1.8	5.7	-0.7	0.1	-1.3	0.4	1.8	2.4
Medication: Lisinopril	1.2	1.6	4.4	1.5	2.1	0.7	0.6	0.7	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	4.4	-1.0	-1.2	-1.4	-0.1	-2.1	-0.8
Neuroticism (Nagel 2018)	1.1	2.6	7.0	-2.3	-0.5	-1.3	-0.7	1.1	2.6
Alzheimer’s Disease (in father)	1.1	1.1	3.7	1.3	0.3	-0.3	-0.1	-1.9	-1.2
Blood Eosinophil Count	1.1	8.5	40.6	-0.1	-6.4	2.0	-1.1	-2.2	-0.6
Pulse rate	1.1	1.9	5.9	1.2	2.4	-1.1	-0.5	-0.3	-1.6
Happiness	1.1	1.3	3.0	-1.2	-1.7	-1.0	0.0	0.3	1.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	4.9	-1.6	-2.2	-0.7	-0.1	0.1	0.9
Osteoporosis (self-reported)	1.1	1.3	6.3	0.6	-2.5	1.0	0.5	-0.2	-0.3
Fasting Glucose	1.0	1.3	5.6	-0.1	0.5	0.5	0.2	2.4	1.2
LDL Cholesterol	1.0	1.6	7.5	-0.9	-0.9	-0.3	-0.6	-0.2	2.7
Rheumatoid Arthritis	1.0	1.4	3.3	1.8	-0.9	1.8	0.6	0.9	-0.2
Fed-up feelings	1.0	1.8	6.7	-1.0	-0.2	-1.3	-0.9	0.5	2.6
Financial difficulties in last 2 years	1.0	1.3	2.8	-0.7	-0.4	-1.0	0.8	1.6	1.7
Glaucoma (self-reported)	1.0	1.2	4.5	-0.7	0.9	-1.0	-0.7	-2.1	0.1
Angina (self-reported)	1.0	1.3	5.6	0.2	0.1	-1.0	-0.6	0.9	2.4
Ever depressed for a whole week	1.0	1.2	2.4	0.5	1.4	-0.1	1.5	0.8	1.5
Commuting to job workplace: Cycle	1.0	1.2	2.6	0.2	-0.6	1.1	1.5	-0.9	-1.6
Heart attack/myocardial infarction (self-reported)	1.0	1.2	3.0	-0.7	-1.2	-0.7	0.3	1.4	1.7
Depressed Affect (Nagel 2018)	0.9	2.0	7.0	-1.5	0.0	-0.7	-0.7	1.3	2.6
Average weekly spirits intake	0.9	1.2	3.3	-1.1	-0.4	-1.0	-0.8	0.8	1.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.3	1.5	0.2	1.5	1.3	-0.5	-0.7
Angina	0.9	1.2	5.5	-0.0	0.1	-0.8	-0.6	0.7	2.4
Medication: Co-codamol	0.9	1.1	2.8	0.9	1.2	-0.6	-0.9	-1.7	0.4
Father’s age at death	0.9	1.2	3.7	0.8	1.9	1.3	-0.2	1.1	-0.3
Lung cancer (father)	0.9	1.1	2.3	-1.1	-1.1	-1.5	-1.2	-0.5	0.4
Loud music exposure frequency	0.9	1.0	3.4	-1.1	-1.8	0.2	0.1	-0.9	-0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	4.2	1.6	-0.9	0.0	-0.0	-1.0	-2.0
Pulse wave peak to peak time	0.9	1.1	3.2	-1.8	-0.7	0.8	0.3	-0.6	1.2
Knee pain experienced in last month	0.9	1.3	3.2	1.8	-0.0	0.6	1.8	0.4	-1.1
Illnesses of siblings: Diabetes	0.9	1.1	2.0	1.4	1.4	-0.1	1.4	1.0	0.4
Average weekly red wine intake	0.9	1.3	3.1	1.2	-0.9	1.0	-0.4	-1.0	-1.8
Ever had bowel cancer screening	0.9	1.1	1.8	0.9	-0.2	1.3	0.7	-1.2	-1.3
Medication for cholesterol	0.9	1.3	4.7	-0.8	-2.2	-0.6	-0.6	0.9	1.0
Intelligence (Savage-Jansen 2018)	0.8	2.4	6.5	0.8	-0.8	0.6	-1.6	-2.6	-2.0
Crohns Disease (2012)	0.8	1.3	3.5	-1.4	-0.5	-1.1	-1.9	-0.8	0.4
Taking other prescription medications	0.8	1.3	2.1	-1.3	-1.4	0.1	-1.3	-1.4	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.8	-0.4	-0.8	0.1	1.4	-2.6	-1.2
Medication: Cholesterol lowering	0.8	1.2	3.4	-1.3	1.8	-0.1	0.1	0.7	1.2
Pulse wave Arterial Stiffness index	0.8	0.9	2.4	1.6	0.7	-0.9	-0.4	0.5	-1.1
Tense / ‘highly strung’	0.8	1.3	3.0	-1.7	-1.1	0.9	0.7	1.1	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.9	-0.4	-1.2	-0.3	-0.0	1.2	1.7
Risk taking	0.8	1.1	2.5	1.3	0.1	0.4	-1.6	0.8	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.4	-1.8	-1.0	-0.0	-0.7	0.4	0.9
Supplements: Calcium	0.8	0.9	2.4	0.0	1.2	-0.2	-0.3	-1.6	-1.1
Alcohol drinker status: Previous	0.8	1.0	2.4	-0.9	-0.6	0.1	0.7	-1.6	-1.3
Relative age voice broke	0.7	1.0	1.8	-1.4	-0.9	-0.0	-1.1	1.1	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.1	-0.1	-1.5	0.1	1.8	-1.7	-0.9
Stomach or abdominal pain in last month	0.7	0.9	2.1	0.0	-1.0	0.9	0.8	1.4	0.8
Past tobacco smoking	0.7	1.3	2.2	1.3	1.5	0.6	1.3	1.5	-0.1
Alcohol usually taken with meals	0.7	1.1	2.9	0.8	1.2	1.7	-1.0	-0.2	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.1	-1.1	-1.1	-0.9	0.1	-0.4	1.8
Diabetes (self-reported)	0.7	1.1	2.7	0.5	0.9	1.7	1.2	0.8	-0.6
Falls in the last year	0.7	1.0	1.7	-1.2	-1.3	-1.2	0.5	-0.7	0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	6.8	-1.6	-1.7	-2.6	-1.0	-0.1	-0.6
Mouth/teeth dental problems: Dentures	0.7	1.2	2.2	1.3	1.5	1.1	1.2	-0.4	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.8	0.1	-0.6	-0.8	-1.0	-1.7	-1.0
Depression (self-reported)	0.7	0.8	2.8	0.1	-1.7	1.0	0.1	0.9	0.4
Prospective memory result	0.7	0.9	1.2	-1.1	-1.0	-1.0	0.8	0.8	0.9
Length of working week for main job	0.7	0.8	1.9	0.1	-1.4	1.2	-1.2	0.3	0.3
Headache pain in last month	0.7	1.2	2.1	-0.9	-1.4	-1.4	0.1	1.1	1.2
Eye problems/disorders: None of the above	0.7	0.9	2.6	0.2	0.5	-1.0	-0.8	1.6	0.9
Medication: Ibuprofen	0.7	0.8	2.9	-0.7	-0.5	-0.5	-0.7	-1.7	-0.7
Supplements: Vitamin C	0.7	0.8	3.5	-0.2	0.6	0.4	1.9	0.7	-0.6
Qualifications: nursing, teaching	0.7	1.1	3.4	1.3	-0.0	0.9	0.3	-0.6	-1.8
Osteoarthritis (self-reported)	0.7	0.9	2.6	0.7	-0.3	1.6	1.1	0.2	-1.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	-0.2	0.9	1.3	0.7	1.0	1.1
Fractured/broken bones in last 5 years	0.7	0.9	3.8	0.2	-1.9	0.1	0.2	1.0	0.8
Basal cell carcinoma (self-reported)	0.7	0.8	1.9	-0.9	1.2	-1.4	-0.8	-0.0	-0.3
Reaction Time	0.6	1.2	2.2	1.3	1.4	-0.4	0.3	1.5	0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.6	0.8	0.3	-0.3	-1.0	-2.2	-1.6
Prostate Cancer	0.6	0.9	3.8	-0.6	-0.8	-1.9	-0.3	-0.1	0.6
Primary Biliary Cirrhosis	0.6	0.9	3.0	-1.0	-1.7	-0.6	-0.3	-0.7	0.8
Smoking Status	0.6	1.3	4.0	-0.8	-1.1	-2.0	-0.6	-1.3	0.5
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.9	-0.6	-1.7	-0.9	0.2	-0.3	1.1
Severe depression (siblings)	0.6	0.6	1.0	1.0	0.4	1.0	0.3	-0.8	-1.0
Current tobacco smoking	0.6	1.0	4.5	0.5	0.9	-2.1	0.1	0.5	0.3
Multivitamins +/- minerals	0.6	0.7	2.5	-0.5	-0.5	-0.5	-1.6	0.3	1.0
Qualifications: None of the above	0.6	1.2	5.0	-1.2	0.7	-0.4	-0.2	0.4	2.2
Fluid intelligence score	0.6	1.2	3.4	0.9	-0.0	0.5	-0.6	-1.6	-1.8
Hip circumference	0.6	2.7	7.2	-1.8	-0.8	-1.6	-1.4	-2.7	0.1
Number of live births	0.6	0.9	3.2	0.2	-0.9	1.8	1.0	0.4	0.2
Illnesses of mother	0.6	0.8	2.0	-1.4	-1.3	0.1	-0.1	0.5	0.7
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.9	-0.7	-1.7	-0.7	0.1	-0.8	0.2
Medication: Amlodipine	0.6	0.9	2.3	-0.9	0.5	0.4	-0.7	1.5	1.1
High blood pressure (siblings)	0.6	0.8	3.2	-0.7	-0.6	0.6	-0.2	-1.8	-0.9
Medication: Blood pressure	0.6	1.0	2.9	-1.1	1.1	-0.3	0.5	0.7	1.7
Mean time to correctly identify matches	0.6	1.2	3.4	1.4	1.8	0.7	0.3	0.9	0.6
Number of full sisters	0.6	0.8	2.5	-0.3	-1.1	0.1	-0.3	1.6	0.9
Age at last live birth	0.6	0.8	2.0	1.0	-1.0	0.8	1.4	0.2	-0.4
Illnesses of father: Heart disease	0.6	0.8	2.2	1.0	1.5	0.6	0.6	0.6	-0.6
Smoking status: Previous	0.6	0.8	1.7	-1.1	-1.3	-0.4	-0.5	-1.3	-0.3
Back pain experienced in last month	0.6	0.9	1.9	1.1	-0.6	-0.6	0.4	-1.4	-1.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.8	-1.1	-1.4	-0.9	-0.6	0.0	0.3
Smoking status: Current	0.6	0.9	4.1	0.5	0.7	-2.0	-0.4	0.6	0.5
Hearing aid user	0.6	0.6	2.9	0.5	-1.7	-0.2	0.5	0.6	0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	0.9	1.0	0.0	0.4	1.2	-0.8
Ever smoked	0.6	1.0	2.0	-1.3	-1.4	-0.8	-0.9	-1.0	-0.1
Schizophrenia vs Biploar Disorder	0.5	0.7	1.9	-1.4	-0.3	-0.7	-0.2	-1.3	0.1
Worry (Nagel 2018)	0.5	1.2	4.4	-2.1	-0.5	-0.5	-0.7	-0.6	1.1
Crohns Disease (2017)	0.5	1.1	4.4	-0.4	-0.1	-1.1	-2.1	-0.8	0.7
Ulcerative Colitis (UC)	0.5	0.9	3.3	-0.6	-0.8	-0.6	0.4	-1.8	-0.5
Ovarian Cancer	0.5	0.7	1.4	-0.2	1.0	-0.0	1.1	0.7	1.2
HDL Cholesterol	0.5	0.9	2.3	0.3	-1.3	0.7	0.7	-0.4	-1.5
Schizophrenia (2014)	0.5	1.0	4.4	-0.2	0.5	-2.1	-0.4	-0.9	-0.6
Lung FVC	0.5	2.6	6.0	-1.0	-0.6	-2.4	-0.9	-1.2	-2.4
Hearing difficulty/problems: Yes	0.5	0.8	2.4	-0.1	-1.6	-0.4	0.4	-1.3	-0.3
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	-0.5	-0.2	0.5	1.2	0.1	1.2
Qualifications: CSEs or equivalent	0.5	0.7	1.9	0.2	-1.4	-0.7	0.5	1.0	0.5
High blood pressure (mother)	0.5	0.7	2.8	0.8	0.1	-1.7	0.6	-0.2	-0.6
Trunk fat mass	0.5	2.0	5.7	-1.4	-1.1	-1.3	-1.2	-2.4	0.2
Had menopause	0.5	0.6	1.9	-0.4	0.8	-0.5	-0.3	0.7	1.4
Had other major operations	0.5	0.6	2.2	0.6	-1.5	1.0	0.2	0.6	-0.1
Forced vital capacity (FVC)	0.5	2.0	5.2	-1.1	-2.0	-2.3	-1.2	0.0	-0.6
Allergy	0.5	1.1	5.1	-0.0	0.8	-0.5	2.2	-0.4	-0.8
Medication: Ramipril	0.5	0.6	1.5	-0.8	-0.3	-1.2	-0.7	-0.7	-0.7
Arm fat percentage (right)	0.5	1.9	5.2	-1.3	-0.7	-1.4	-1.6	-2.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	3.6	-1.2	-1.4	-1.9	-0.7	0.8	-0.8
Birth weight of first child	0.5	0.8	2.0	-1.4	0.5	-0.4	1.4	0.8	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.1	-0.1	1.4	-0.9	-0.8	-1.1	-0.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.9	0.7	0.1	0.5	-0.3	-0.8	-1.4
Exposure to tobacco smoke outside home	0.5	0.7	2.7	-0.8	-1.7	-0.4	-0.1	-0.6	-0.2
Number of children fathered	0.5	0.5	1.2	-0.6	1.1	0.7	0.2	0.5	0.9
Arm fat percentage (left)	0.5	1.9	4.9	-1.4	-0.8	-1.4	-1.5	-2.2	0.2
Mood swings	0.5	0.9	3.8	-0.4	0.6	-0.2	-0.7	0.8	1.9
Commuting to job workplace: Walk	0.5	0.6	1.6	-0.1	1.3	-1.0	0.1	0.8	0.4
Eye problems/disorders: Cataract	0.5	0.5	1.1	0.7	0.4	1.0	1.0	0.4	-0.4
Medication: Gliclazide	0.5	0.5	1.2	-0.7	-0.1	0.8	-1.1	-1.0	0.0
Arm fat mass (left)	0.5	1.9	4.1	-1.5	-0.9	-1.4	-1.4	-2.0	0.6
Number of self-reported non-cancer illnesses	0.5	0.9	2.2	-0.8	-1.0	0.1	-1.5	0.6	1.1
Average weekly champagne plus white wine intake	0.5	0.6	1.8	-0.5	0.4	-0.2	-0.9	-0.9	-1.3
Eye problems/disorders: Glaucoma	0.5	0.6	2.2	-0.8	-0.3	-0.4	0.6	-1.5	-0.0
Alcohol drinker status: Never	0.5	0.7	1.7	0.1	0.0	1.1	1.1	-1.3	0.0
Number of operations (self-reported)	0.5	0.8	3.2	-0.1	-1.8	0.8	-0.9	0.1	-0.2
Irritability	0.5	0.8	2.6	-0.5	-0.4	-0.7	-0.6	1.0	1.6
Irritable Bowel Disease (IBD)	0.4	0.8	1.6	-0.8	-0.4	-1.1	-1.0	-1.3	0.6
Major Depression (MDD)	0.4	0.5	1.9	-0.1	-0.0	0.5	0.3	-1.4	-0.9
Blood White Count	0.4	2.7	7.5	1.3	2.2	1.2	0.7	-0.1	-2.7
BMI	0.4	2.2	5.7	-2.0	-0.7	-0.9	-0.5	-2.4	1.4
Supplements: Zinc	0.4	0.5	1.6	-0.0	-0.3	-0.4	0.3	-0.9	-1.3
Trunk fat percentage	0.4	1.7	4.1	-1.4	-1.3	-1.1	-1.3	-2.0	0.3
Age when periods started (menarche)	0.4	1.0	2.5	1.2	1.6	-1.1	-0.4	0.7	-0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	-0.2	0.9	-0.8	-0.5	0.9	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.7	0.3	0.8	1.1	-1.3	1.0	0.7
Hearing difficulty/problems with background noise	0.4	0.7	1.9	0.2	-1.4	0.2	0.6	-1.4	-0.3
Weight	0.4	2.0	4.7	-1.7	-1.0	-1.6	-0.9	-2.2	0.7
Arm fat mass (right)	0.4	1.7	4.3	-1.4	-0.8	-1.2	-1.2	-2.1	0.4
Breastfed as a baby	0.4	0.4	1.3	-1.1	0.2	-0.7	-0.2	-0.8	0.1
Hair/balding pattern: Pattern 4	0.4	1.0	2.1	-0.8	1.1	-0.8	-1.0	-1.5	0.4
Forced vital capacity (FVC), Best measure	0.4	1.4	2.3	-1.2	-1.5	-1.5	-0.8	0.2	-1.3
Body fat percentage	0.4	1.7	4.4	-1.4	-1.1	-1.1	-1.2	-2.1	0.3
Comparative body size at age 10	0.4	1.1	2.2	1.5	-0.9	0.8	0.7	0.8	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	2.3	-0.5	-0.8	-0.1	-0.3	-0.1	1.5
Health satisfaction	0.4	0.5	1.4	1.2	0.2	1.0	-0.1	0.7	0.6
Qualifications: College or University degree	0.4	1.3	6.4	0.8	-0.2	0.6	-0.3	-0.2	-2.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.6	0.8	-0.5	0.2	1.3	0.1	-0.1
Whole body fat mass	0.4	1.5	4.6	-1.2	-1.2	-0.9	-0.8	-2.1	0.3
Pulse rate, automated reading	0.4	1.3	4.4	0.8	2.1	-0.7	-0.6	0.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	0.4	-0.7	0.0	-0.3	1.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.7	-0.9	-0.9	-0.8	-0.5	1.3	1.0
Diabetes diagnosed by doctor	0.4	0.7	1.6	0.7	0.7	1.3	1.1	0.7	-0.3
Breast cancer (self-reported)	0.4	0.5	1.0	0.9	0.4	0.8	0.7	0.3	-1.0
Medication: Atorvastatin	0.4	0.5	1.4	0.1	0.5	1.1	1.2	0.4	-0.4
Unable to work because of sickness or disability	0.4	0.5	1.6	-0.3	1.3	-0.9	0.3	-0.4	-0.5
Pain experienced in last month	0.4	0.6	1.8	-0.5	1.4	0.5	-1.2	-0.2	0.1
Schizophrenia (2018)	0.3	0.5	2.4	0.3	-0.0	-1.6	0.2	-0.6	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.3	-0.1	-0.8	-0.8	-0.8	-0.6
Body Mass Index (BMI) (2010)	0.3	0.5	1.9	-0.8	-0.1	0.1	1.4	-0.1	-0.4
Systolic Blood Pressure	0.3	1.3	3.4	-1.4	-0.2	-1.0	0.2	1.0	1.9
Cardiovascular Disease	0.3	0.9	1.8	-1.3	1.1	-1.0	0.5	0.3	1.2
Number of treatments/medications taken	0.3	0.5	0.9	-0.7	-0.5	0.9	0.6	-0.2	1.0
Systolic blood pressure, automated reading	0.3	0.9	2.1	-1.0	1.3	-0.6	0.3	0.0	1.4
Vitamin and mineral supplements	0.3	0.3	1.0	0.4	-1.0	0.2	0.9	-0.2	0.1
Pack years adult smoking proportion	0.3	0.5	1.0	-0.2	-0.5	-1.0	0.0	-1.0	0.9
Townsend deprivation index at recruitment	0.3	0.4	1.3	0.5	-0.3	-0.3	-0.8	0.4	-1.1
High blood pressure	0.3	0.8	2.3	0.4	1.2	-0.0	1.5	1.1	-0.4
Medication: Levothyroxine sodium	0.3	0.5	1.0	-0.3	0.8	0.9	0.8	-1.0	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.4	1.3	0.4	0.1	0.5	0.1	0.8	1.1
Body mass index (BMI)	0.3	1.1	4.1	-1.2	-0.5	-0.8	-0.5	-2.0	0.5
Waist circumference	0.3	1.0	3.1	-0.9	0.6	-0.8	-0.7	-1.8	0.9
Nervous feelings	0.3	0.5	1.6	-0.7	-0.2	-0.8	-0.1	0.5	1.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	0.1	0.9	-0.7	-0.7	0.3	0.6
Mouth/teeth dental problems	0.3	0.4	1.3	-0.6	0.2	0.0	-1.1	-0.3	-0.9
Illnesses of siblings	0.3	0.4	1.4	1.2	-0.3	0.2	0.0	1.0	-0.3
Hair/balding pattern: Pattern 3	0.3	0.5	1.0	-1.0	-0.7	0.4	0.4	-0.9	-0.4
Peak expiratory flow (PEF)	0.3	0.6	2.6	-0.6	-1.6	-0.7	0.1	0.1	0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.9	-0.6	0.9	-0.2	0.3	0.5
Birth weight	0.3	0.7	1.9	0.3	1.4	-0.1	0.4	1.3	0.6
Leg fat percentage (right)	0.3	1.0	4.0	-0.7	-0.9	-0.4	-0.6	-2.0	0.0
Heart disease (mother)	0.3	0.4	1.3	0.1	-0.6	-0.3	0.7	-0.3	1.2
Leg fat mass (right)	0.3	1.1	3.8	-0.9	-1.1	-0.7	-0.2	-2.0	0.3
Medication: Aspirin	0.3	0.4	1.2	0.3	0.4	0.5	0.2	0.8	1.1
Hypertension (Self-reported)	0.3	0.8	2.4	0.4	1.0	-0.2	1.5	1.0	-0.0
Long-standing illness, disability or infirmity	0.3	0.4	1.3	1.1	0.0	-0.0	1.1	-0.5	-0.1
Medication: Aspirin	0.3	0.4	1.4	0.1	-0.3	0.4	0.2	0.7	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.7	-1.3	-0.5	-0.8	-0.5	1.1	-0.2
Wears glasses or contact lenses	0.3	0.3	1.1	-0.3	0.6	1.1	0.6	-0.2	-0.0
Mother’s age at death	0.3	0.4	0.8	0.6	0.7	0.6	-0.9	-0.6	-0.4
Financial situation satisfaction	0.3	0.4	0.9	0.3	-0.4	-0.8	-0.5	0.3	1.0
Commuting to job workplace: Public transport	0.3	0.3	0.7	-0.5	0.7	-0.1	0.9	0.3	0.6
Medication: Blood pressure	0.3	0.6	0.9	0.8	0.9	0.8	0.5	-0.7	-0.9
High cholesterol (Self-reported)	0.3	0.5	1.3	-0.9	1.1	0.7	0.0	0.3	0.0
Illnesses of father: High blood pressure	0.3	0.3	0.8	-0.8	-0.4	0.1	0.5	0.1	0.9
Leg fat percentage (left)	0.3	1.0	4.2	-0.7	-0.5	-0.5	-0.9	-2.0	0.0
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.8	-0.2	-0.8	-0.2	-1.7	-1.3	-0.3
Heart disease (siblings)	0.3	0.3	0.9	-0.2	-0.2	-1.0	0.0	-0.1	1.0
Pack years of smoking	0.3	0.4	1.0	-0.2	-0.2	-0.9	-0.3	-1.0	0.8
Bipolar Disorder (2018)	0.2	0.4	0.8	0.9	0.0	0.7	-0.7	0.6	-0.1
Age at First Birth	0.2	0.3	1.2	-0.3	-0.4	0.3	0.1	-0.4	1.1
Neuroticism (2016)	0.2	0.3	1.2	-1.1	-0.5	-0.2	-0.3	0.2	0.6
Triglycerides	0.2	0.3	1.4	0.4	-0.3	0.0	1.2	-0.6	-0.3
Waist Hip Ratio (WHR)	0.2	0.9	1.6	1.0	1.2	1.3	0.4	1.1	0.4
Allergy or Eczema	0.2	0.5	1.3	0.3	1.1	0.6	-1.2	0.0	-0.0
Hypothyroidism (self reported)	0.2	0.5	1.0	-0.2	0.3	0.3	1.0	-0.8	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.7	-0.1	0.7	-0.7	-0.0	0.8	0.2
Hand grip strength (left)	0.2	0.4	1.2	0.1	0.0	-0.4	1.0	-1.1	-0.4
Relative age of first facial hair	0.2	0.4	1.6	-0.8	-1.3	-0.1	-0.3	0.4	-0.3
Medication: Metformin	0.2	0.2	0.6	-0.0	-0.6	0.2	0.6	0.4	0.8
Diabetes (mother)	0.2	0.3	0.8	-0.0	-0.4	0.7	-0.4	-0.9	0.2
Impedance of leg (right)	0.2	0.8	3.7	0.6	-0.8	-0.1	0.0	1.9	-0.0
Leg fat-free mass (left)	0.2	1.1	2.5	-1.3	-1.2	-1.0	-0.3	-1.6	0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.4	-0.3	0.3	0.5	-0.3	-0.6
Leg predicted mass (left)	0.2	1.1	2.4	-1.2	-1.2	-0.9	-0.3	-1.6	0.3
Medication: Simvastatin	0.2	0.3	0.6	-0.8	0.8	0.5	-0.4	0.3	-0.6
Impedance of arm (right)	0.2	0.7	2.3	-0.4	-0.6	-1.1	-1.5	0.6	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	-0.2	-0.7	-0.8	-0.0	-0.2	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	-0.9	-0.9	0.5	0.3	0.8	0.2
Impedance of arm (left)	0.2	0.8	2.1	-0.6	-0.6	-1.1	-1.4	0.7	0.1
Exposure to tobacco smoke at home	0.2	0.3	0.7	0.4	0.7	-0.5	-0.8	0.0	0.2
Medication: Paracetamol	0.2	0.3	1.2	0.0	0.3	0.5	-0.2	-0.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-0.4	0.3	0.5	1.0	-0.9	0.7
Arm fat-free mass (right)	0.2	0.8	1.7	-1.0	-1.0	-0.9	-0.1	-1.3	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	0.1	0.2	0.3	0.6	-0.1	0.8
Age at first live birth	0.2	0.4	0.8	-0.4	-0.3	-0.9	0.6	-0.7	-0.6
Shortness of breath walking on level ground	0.2	0.2	0.9	-0.3	-0.1	0.9	-0.1	0.3	0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	1.3	0.9	0.2	-0.2	0.5	-0.3	-1.1
Arm predicted mass (right)	0.2	0.8	2.3	-0.9	-0.9	-0.9	0.1	-1.5	0.1
Alcohol intake frequency.	0.2	0.5	2.3	0.4	0.1	0.4	0.4	-1.5	-0.3
Suffer from ‘nerves’	0.2	0.3	0.9	-1.0	-0.5	0.3	-0.2	-0.0	0.8
Overall health rating	0.2	0.4	0.8	0.3	0.7	-0.7	0.8	0.3	0.9
Leg fat-free mass (right)	0.2	1.1	3.0	-1.2	-0.9	-1.1	-0.4	-1.7	0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.7	0.2	0.1	-1.3	-0.2	0.1	0.6
Leg predicted mass (right)	0.2	1.0	2.7	-1.2	-1.0	-1.0	-0.3	-1.6	0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	0.5	-0.7	0.1	0.8	-0.6	0.0
Medication: Bendroflumethiazide	0.2	0.4	1.8	-0.1	-0.4	-0.3	1.3	-0.4	0.2
Medication: Paracetamol	0.2	0.3	0.6	-0.5	0.1	0.2	-0.1	-0.8	-0.8
Basal metabolic rate	0.2	1.1	2.7	-1.2	-0.9	-1.1	-0.6	-1.6	0.4
Diastolic blood pressure, automated reading	0.2	0.6	1.8	0.2	0.0	-0.7	0.7	-0.8	-1.3
Leg fat mass (left)	0.2	1.0	3.6	-0.9	-0.8	-0.7	-0.3	-1.9	0.3
Arm predicted mass (left)	0.2	0.9	1.9	-1.1	-0.9	-0.9	-0.6	-1.4	0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.8	-0.0	-0.8	-0.3	-0.1	-0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	0.2	-0.5	-0.1	0.4	0.6	0.1
Heel T-Score	0.1	0.8	2.3	-0.3	-0.2	-1.5	-0.2	-0.5	-1.5
Lung FEV1/FVC ratio	0.1	0.3	0.8	-0.7	0.3	-0.7	0.1	0.9	0.2
Chronotype (morning person)	0.1	0.3	0.5	-0.2	-0.7	0.7	-0.3	0.5	-0.5
Tanning	0.1	0.9	2.7	0.1	0.9	0.1	0.8	-1.2	-1.6
Hand grip strength (right)	0.1	0.3	1.7	0.0	1.3	0.1	0.2	-0.4	0.1
Sitting height	0.1	0.7	1.9	-1.3	-0.3	-1.4	-0.4	-0.4	0.0
Impedance of leg (left)	0.1	0.5	2.6	0.5	-0.6	-0.2	-0.1	1.6	-0.2
Number of incorrect matches in round	0.1	0.1	0.4	0.5	0.7	0.2	0.1	-0.0	0.4
Trunk fat-free mass	0.1	0.5	1.7	-0.8	-0.5	-0.6	-0.5	-1.3	0.1
Trunk predicted mass	0.1	0.5	1.7	-0.8	-0.6	-0.6	-0.4	-1.3	0.1
Standing height	0.1	1.1	2.8	-1.0	-1.2	-1.7	-1.0	-0.1	0.4
Pulse wave reflection index	0.1	0.1	0.4	0.1	0.4	0.1	0.7	-0.3	-0.1
Gout (self-reported)	0.1	0.1	0.2	0.3	0.4	-0.0	-0.4	0.0	-0.4
Medication: Allopurinol	0.1	0.1	0.4	-0.1	-0.6	0.4	0.5	0.1	-0.2
Comparative height size at age 10	0.1	0.3	0.6	0.0	-0.7	-0.5	-0.5	-0.8	-0.6
Whole body fat-free mass	0.1	0.8	2.3	-1.0	-0.9	-0.8	-0.4	-1.5	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	0.1	0.2	0.1	0.6	-0.1	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.1	-0.5	-0.0	0.0	-0.2	0.1
Mineral and other dietary supplements	0.1	0.1	0.2	0.4	-0.4	-0.5	0.0	0.1	-0.1
Whole body water mass	0.1	0.8	2.0	-1.1	-0.8	-0.9	-0.4	-1.4	0.3
Arm fat-free mass (left)	0.1	0.7	1.2	-0.9	-0.6	-1.1	-0.4	-1.1	0.4
Cholesterol lowering medication	0.1	0.2	0.5	0.3	-0.1	0.7	0.2	0.7	-0.4
Impedance of whole body	0.1	0.6	1.9	-0.1	-0.7	-0.8	-0.9	1.4	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.3	0.0
Height	0.0	0.7	1.3	-0.2	-0.9	-1.1	-0.3	-1.0	-1.0
Hair Pigment	0.0	0.6	1.5	0.5	1.2	0.7	0.9	0.0	-0.6

Hub : Genes

TST

Models

Trait associations