[Hub]/) : Traits : Blood Platelet Count : ←

chr22:49,315,766-51,219,006

Best TWAS P=2e-77 · Best GWAS P=1.52e-63 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	SELO	0.07	0.04	blup	49	0.03	2.2e-04	13.5643	18.6	2.0e-77	0.35	0.22	0.20	TRUE
20	GTEx	Brain Cerebellum	TRABD	0.32	0.01	lasso	8	0.07	5.3e-03	-15.1335	16.5	6.8e-61	0.41	0.10	0.08	TRUE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SELO	0.04	0.03	lasso	3	0.03	2.0e-04	14.5450	15.1	8.5e-52	0.29	0.11	0.04	TRUE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SELO	0.05	0.01	blup	49	0.03	7.6e-04	11.7743	14.2	9.0e-46	0.33	0.16	0.21	TRUE
76	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CRELD2	0.15	0.00	blup	39	0.04	4.2e-03	12.1359	12.9	2.6e-38	-0.01	0.01	0.97	TRUE
52	GTEx	Uterus	PPP6R2	0.55	-0.01	enet	46	0.00	2.9e-01	-2.7212	11.4	7.0e-30	0.12	0.04	0.10	TRUE
3	CommonMind	Brain Pre-frontal Cortex	CRELD2	0.03	0.01	lasso	5	0.02	2.9e-03	11.6965	11.2	5.1e-29	0.02	0.27	0.03	TRUE
64	YFS	Blood	PLXNB2	0.02	0.02	lasso	4	0.02	3.6e-07	-8.3502	9.8	1.9e-22	0.16	0.99	0.00	TRUE
80	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PANX2	0.12	0.05	blup	52	0.10	2.4e-05	-5.2430	7.1	1.6e-12	0.20	0.09	0.04	TRUE
25	GTEx	Breast Mammary Tissue (Female)	CPT1B	0.16	0.00	enet	16	0.07	4.7e-03	0.0087	-5.5	5.1e-08	-0.13	0.06	0.06	TRUE
60	NTR	Blood	C22orf34	0.15	0.12	enet	28	0.15	3.4e-45	5.1118	5.2	2.3e-07	-0.03	1.00	0.00	TRUE
95	The Cancer Genome Atlas	Thyroid Carcinoma	SELO	0.07	0.06	lasso	5	0.05	5.9e-06	13.5643	16.2	4.1e-59	0.30	0.24	0.69	FALSE
49	GTEx	Thyroid	SELO	0.15	0.06	lasso	3	0.06	2.1e-05	13.5643	14.7	8.2e-49	0.22	0.66	0.02	FALSE
35	GTEx	Lung	TUBGCP6	0.10	0.02	enet	9	0.02	9.5e-03	13.5643	14.5	2.5e-47	0.28	0.20	0.06	FALSE
19	GTEx	Brain Cerebellum	TUBGCP6	0.37	0.00	lasso	6	0.01	1.5e-01	4.5293	14.3	2.6e-46	0.28	0.07	0.06	FALSE
29	GTEx	Esophagus Mucosa	SELO	0.19	0.10	lasso	4	0.08	2.7e-06	13.8255	14.2	1.7e-45	0.27	0.95	0.00	FALSE
7	CommonMind	Brain Pre-frontal Cortex	TUBGCP6	0.14	0.10	lasso	5	0.10	6.3e-12	13.8870	13.4	6.7e-41	0.31	1.00	0.00	FALSE
14	GTEx	Artery Tibial	SELO	0.09	0.05	lasso	4	0.06	1.8e-05	13.6019	12.5	1.3e-35	0.25	0.81	0.01	FALSE
46	GTEx	Stomach	SELO	0.13	0.08	lasso	2	0.05	2.1e-03	13.6019	12.4	1.7e-35	0.21	0.21	0.05	FALSE
47	GTEx	Testis	CRELD2	0.26	0.18	lasso	7	0.17	6.7e-08	12.1133	-12.3	4.9e-35	0.08	0.99	0.00	FALSE
31	GTEx	Heart Atrial Appendage	CRELD2	0.19	0.04	lasso	4	0.02	6.7e-02	12.1133	12.3	1.3e-34	-0.08	0.58	0.02	FALSE
45	GTEx	Skin Sun Exposed Lower leg	CRELD2	0.08	0.03	lasso	2	0.02	6.7e-03	12.1359	12.2	1.7e-34	-0.09	0.67	0.01	FALSE
17	GTEx	Brain Cerebellar Hemisphere	ZBED4	0.17	0.15	lasso	2	0.17	3.6e-05	12.1359	-12.1	5.9e-34	0.08	0.28	0.05	FALSE
24	GTEx	Breast Mammary Tissue (Female)	CRELD2	0.07	-0.01	lasso	6	-0.01	6.5e-01	11.7516	12.1	1.3e-33	-0.07	0.08	0.05	FALSE
16	GTEx	Artery Tibial	CRELD2	0.09	0.09	lasso	1	0.08	1.5e-06	12.0528	12.1	1.9e-33	-0.07	0.98	0.00	FALSE
43	GTEx	Pancreas	ALG12	0.22	0.15	lasso	4	0.15	7.9e-07	11.5692	12.0	2.9e-33	-0.07	0.90	0.00	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	CRELD2	0.04	0.06	lasso	1	0.06	1.7e-06	11.6965	11.7	1.3e-31	-0.06	0.02	0.98	FALSE
63	YFS	Blood	CRELD2	0.12	0.22	lasso	9	0.23	3.4e-73	11.9783	11.7	1.6e-31	-0.06	1.00	0.00	FALSE
36	GTEx	Lung	CRELD2	0.10	0.07	lasso	2	0.08	1.1e-06	12.1359	11.6	3.5e-31	-0.10	0.96	0.00	FALSE
84	The Cancer Genome Atlas	Lung Adenocarcinoma	SELO	0.04	0.02	enet	7	0.03	3.5e-04	13.8255	11.6	6.2e-31	0.32	0.27	0.25	FALSE
40	GTEx	Muscle Skeletal	RP3-402G11.26	0.18	0.05	lasso	6	0.13	1.5e-12	-0.7290	11.5	2.2e-30	0.09	0.93	0.02	FALSE
18	GTEx	Brain Cerebellum	ZBED4	0.30	0.07	lasso	3	0.11	4.6e-04	11.3744	-11.4	3.0e-30	0.08	0.37	0.04	FALSE
6	CommonMind	Brain Pre-frontal Cortex	MOV10L1	0.18	0.11	enet	15	0.14	3.6e-16	-7.2140	11.4	4.2e-30	0.18	1.00	0.00	FALSE
13	GTEx	Artery Aorta	CPT1B	0.18	0.00	enet	22	0.02	2.3e-02	-15.2888	-11.2	3.0e-29	-0.11	0.01	0.91	FALSE
82	The Cancer Genome Atlas	Lung Adenocarcinoma	CRELD2	0.04	0.02	blup	39	0.01	1.3e-02	11.2716	11.2	3.6e-29	-0.09	0.02	0.74	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CRELD2	0.03	0.02	blup	38	0.02	3.2e-03	11.2716	11.2	6.9e-29	-0.09	0.02	0.94	FALSE
30	GTEx	Esophagus Mucosa	RP3-402G11.26	0.08	0.00	lasso	3	0.00	1.7e-01	12.3809	11.0	4.2e-28	0.13	0.10	0.03	FALSE
27	GTEx	Colon Transverse	CRELD2	0.17	0.11	enet	9	0.10	2.2e-05	8.2742	10.9	1.5e-27	0.05	0.90	0.01	FALSE
4	CommonMind	Brain Pre-frontal Cortex	MAPK11	0.05	0.02	bslmm	393	0.02	4.5e-04	3.0710	-10.7	7.0e-27	-0.10	0.21	0.02	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALG12	0.03	0.00	blup	43	0.02	2.8e-03	7.6353	10.6	1.9e-26	-0.05	0.02	0.87	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	TRABD	0.03	0.04	lasso	3	0.03	5.5e-04	10.1646	10.5	9.4e-26	0.25	0.04	0.04	FALSE
92	The Cancer Genome Atlas	Skin Cutaneous Melanoma	BRD1	0.17	-0.01	blup	45	0.01	1.4e-01	3.3647	-10.1	8.2e-24	0.06	0.01	0.39	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ALG12	0.04	0.03	lasso	2	0.02	7.6e-04	10.4524	10.0	1.8e-23	-0.05	0.76	0.04	FALSE
41	GTEx	Nerve Tibial	ALG12	0.13	0.04	lasso	6	0.05	2.5e-04	8.2742	9.8	8.4e-23	-0.02	0.89	0.00	FALSE
65	YFS	Blood	ZBED4	0.04	0.03	enet	15	0.04	4.4e-12	7.7146	9.7	4.6e-22	-0.06	1.00	0.00	FALSE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	MAPK11	0.04	0.00	blup	27	0.00	1.6e-01	13.8255	-9.6	5.7e-22	-0.38	0.00	0.06	FALSE
26	GTEx	Colon Sigmoid	CRELD2	0.20	0.07	lasso	6	0.04	1.7e-02	7.4558	9.6	9.5e-22	-0.02	0.18	0.08	FALSE
90	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLC1	0.23	0.18	enet	13	0.09	4.1e-03	-5.8290	-9.3	1.4e-20	-0.34	0.07	0.22	FALSE
56	GTEx	Whole Blood	ZBED4	0.10	0.02	lasso	5	0.03	1.0e-03	11.9783	9.1	7.8e-20	-0.03	0.35	0.02	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	FAM116B	0.03	0.00	blup	16	0.02	2.0e-03	-5.9798	9.1	1.2e-19	0.06	0.01	0.45	FALSE
54	GTEx	Vagina	SCO2	0.36	-0.01	lasso	5	-0.01	6.8e-01	-5.5490	-8.6	7.9e-18	-0.01	0.04	0.06	FALSE
9	GTEx	Adipose Visceral Omentum	PPP6R2	0.19	0.09	enet	7	0.03	7.8e-03	-8.3502	8.5	1.3e-17	0.13	0.10	0.55	FALSE
10	GTEx	Adipose Visceral Omentum	ALG12	0.14	0.01	lasso	6	0.03	1.4e-02	7.3475	8.5	1.5e-17	0.08	0.23	0.04	FALSE
39	GTEx	Muscle Skeletal	RP3-402G11.28	0.13	0.06	lasso	5	0.08	3.2e-08	-3.3109	8.5	1.6e-17	0.22	0.98	0.00	FALSE
48	GTEx	Testis	DENND6B	0.28	0.27	lasso	2	0.25	2.6e-11	-8.0167	-8.4	4.2e-17	-0.14	1.00	0.00	FALSE
61	NTR	Blood	CRELD2	0.02	0.02	lasso	2	0.02	2.9e-06	8.2742	8.3	8.1e-17	0.01	1.00	0.00	FALSE
15	GTEx	Artery Tibial	PPP6R2	0.14	0.07	lasso	4	0.08	5.6e-07	-5.8376	8.3	9.7e-17	0.16	0.97	0.01	FALSE
12	GTEx	Artery Aorta	PPP6R2	0.14	0.14	lasso	3	0.16	2.8e-09	-8.3502	8.3	1.5e-16	0.16	0.98	0.00	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PANX2	0.05	0.02	lasso	3	0.02	4.8e-03	-5.8530	8.3	1.5e-16	0.24	0.08	0.04	FALSE
55	GTEx	Vagina	CTA-384D8.36	0.41	0.01	lasso	8	0.03	7.4e-02	-5.5490	-8.2	1.8e-16	-0.02	0.04	0.06	FALSE
23	GTEx	Breast Mammary Tissue (Female)	ALG12	0.20	-0.01	lasso	7	-0.01	8.6e-01	6.9736	8.2	2.9e-16	-0.01	0.14	0.05	FALSE
51	GTEx	Thyroid	DENND6B	0.09	0.06	lasso	4	0.05	5.3e-05	-8.3502	-8.2	3.4e-16	-0.16	0.86	0.01	FALSE
22	GTEx	Breast Mammary Tissue	ALG12	0.24	-0.01	lasso	9	0.03	8.6e-03	7.3475	7.9	2.2e-15	0.00	0.57	0.03	FALSE
37	GTEx	Muscle Skeletal	SELO	0.22	0.13	lasso	6	0.17	1.2e-16	-2.6420	7.7	1.0e-14	0.22	1.00	0.00	FALSE
91	The Cancer Genome Atlas	Soft Tissue Sarcoma	SELO	0.12	0.02	blup	49	0.05	6.6e-04	-3.5665	7.5	4.8e-14	0.17	0.07	0.11	FALSE
33	GTEx	Heart Left Ventricle	MAPK12	0.30	0.13	enet	14	0.19	3.2e-10	-0.4054	7.5	6.0e-14	0.18	0.96	0.00	FALSE
57	GTEx	Whole Blood	RP3-402G11.25	0.11	0.00	enet	13	0.00	5.3e-01	-8.4918	-7.5	7.4e-14	-0.07	0.05	0.07	FALSE
50	GTEx	Thyroid	CRELD2	0.15	0.03	enet	30	0.03	2.9e-03	8.4719	7.3	2.9e-13	-0.05	0.38	0.02	FALSE
62	NTR	Blood	PPP6R2	0.02	0.01	blup	362	0.01	2.6e-04	-1.4232	6.9	4.5e-12	0.22	0.27	0.04	FALSE
42	GTEx	Pancreas	TRABD	0.22	-0.01	lasso	5	0.01	1.2e-01	0.3678	-6.9	6.2e-12	-0.10	0.05	0.06	FALSE
21	GTEx	Brain Hypothalamus	BRD1	0.36	-0.01	lasso	11	-0.01	5.0e-01	6.8910	6.9	7.1e-12	0.04	0.10	0.06	FALSE
5	CommonMind	Brain Pre-frontal Cortex	MLC1	0.05	0.01	blup	412	0.02	8.2e-04	-5.2005	-6.8	7.3e-12	-0.22	0.25	0.02	FALSE
32	GTEx	Heart Atrial Appendage	MAPK12	0.21	0.11	lasso	2	0.18	1.7e-08	-0.4054	6.8	8.6e-12	0.21	0.51	0.07	FALSE
34	GTEx	Liver	TRABD	0.22	0.02	enet	16	0.05	1.5e-02	-4.3952	-6.8	9.2e-12	-0.14	0.17	0.05	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	MOV10L1	0.08	0.09	enet	8	0.10	3.9e-10	-4.3838	-6.8	9.3e-12	-0.08	1.00	0.00	FALSE
44	GTEx	Pancreas	RP3-402G11.26	0.20	0.04	lasso	4	0.02	4.1e-02	-6.2702	-6.7	2.0e-11	-0.16	0.07	0.04	FALSE
53	GTEx	Vagina	TYMP	0.26	-0.01	lasso	4	0.01	1.8e-01	0.3616	-6.6	3.6e-11	-0.08	0.05	0.06	FALSE
81	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SELO	0.13	0.06	blup	46	0.03	1.7e-02	-2.6420	6.6	4.7e-11	0.23	0.39	0.04	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	MOV10L1	0.05	0.02	lasso	4	0.02	2.7e-03	-5.2005	6.5	8.2e-11	0.03	0.07	0.06	FALSE
38	GTEx	Muscle Skeletal	PPP6R2	0.10	0.08	enet	8	0.06	1.2e-06	-8.0167	6.2	4.6e-10	0.05	0.98	0.00	FALSE
8	GTEx	Adipose Subcutaneous	TRABD	0.11	0.02	lasso	2	0.03	8.1e-04	0.8153	-6.2	5.1e-10	-0.16	0.14	0.04	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MOV10L1	0.04	0.02	blup	92	0.03	2.2e-04	0.7801	6.2	6.6e-10	0.28	0.12	0.17	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	ALG12	0.19	0.02	enet	11	0.02	4.7e-02	7.4558	6.2	7.0e-10	0.00	0.14	0.15	FALSE
85	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MLC1	0.04	0.04	lasso	2	0.04	6.9e-06	-7.1271	-6.0	1.9e-09	-0.19	0.64	0.11	FALSE
86	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SELO	0.05	0.02	blup	49	0.03	1.6e-04	-2.6420	6.0	2.6e-09	0.19	0.33	0.03	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CPT1B	0.10	0.02	blup	301	0.05	6.9e-07	-3.4897	5.9	3.1e-09	0.14	0.39	0.02	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	FAM116B	0.06	0.05	blup	15	0.05	1.3e-05	-8.0167	5.8	6.3e-09	0.22	0.02	0.97	FALSE
68	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PANX2	0.12	0.07	lasso	5	0.07	2.1e-04	-5.2768	5.7	1.5e-08	0.11	0.16	0.04	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MLC1	0.03	0.02	blup	67	0.03	6.1e-04	-3.8436	5.4	7.6e-08	0.18	0.08	0.05	FALSE
58	METSIM	Adipose	LMF2	0.05	0.00	bslmm	323	0.03	3.9e-05	-0.3099	-5.2	1.7e-07	-0.16	0.18	0.05	FALSE
59	METSIM	Adipose	MAPK8IP2	0.03	0.00	enet	11	0.01	3.9e-03	1.1877	-5.2	1.9e-07	-0.28	0.06	0.04	FALSE
11	GTEx	Adipose Visceral Omentum	CHKB-AS1	0.15	0.01	enet	25	0.02	4.8e-02	1.0834	5.2	2.0e-07	-0.02	0.15	0.09	FALSE
70	The Cancer Genome Atlas	Esophageal Carcinoma	C22orf34	0.32	0.20	lasso	3	0.15	1.3e-05	5.0825	5.2	2.4e-07	-0.06	0.01	0.98	FALSE
69	The Cancer Genome Atlas	Colon Adenocarcinoma	C22orf34	0.16	0.16	lasso	7	0.15	5.8e-09	5.0825	5.2	2.6e-07	-0.07	0.01	0.99	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	C22orf34	0.24	0.32	lasso	6	0.37	1.5e-43	5.0600	5.2	2.6e-07	-0.07	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C22orf34	0.19	0.20	lasso	5	0.21	7.6e-18	5.0600	5.1	2.7e-07	-0.07	0.01	0.99	FALSE