Hub : Genes

C22orf34

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.232 0.0370 5.6e-17 0.227 0.173 0.208 0.215 0.223 3.3e-27 1.6e-20 7.6e-25 9.4e-26 1.1e-26
2 NTR Blood 0.145 0.0211 0.0e+00 0.117 0.129 0.147 0.140 0.142 9.2e-36 2.6e-39 3.4e-45 8.4e-43 1.6e-43
3 TCGA Bladder Urothelial Carcinoma 0.192 0.0420 3.7e-13 0.200 0.184 0.212 NA 0.213 8.8e-17 2.0e-15 8.5e-18 NA 7.6e-18
4 TCGA Breast Invasive Carcinoma 0.229 0.0306 0.0e+00 0.368 0.364 0.385 NA 0.381 1.4e-79 1.0e-78 3.3e-84 NA 3.5e-83
5 TCGA Cervical Squamous Cell Carcinoma 0.301 0.0660 2.2e-08 0.159 0.149 0.154 NA 0.207 3.0e-08 8.9e-08 5.2e-08 NA 1.6e-10
6 TCGA Colon Adenocarcinoma 0.162 0.0510 1.3e-06 0.162 0.130 0.138 NA 0.149 1.1e-09 6.2e-08 2.4e-08 NA 5.8e-09
7 TCGA Esophageal Carcinoma 0.316 0.0980 1.2e-04 0.201 0.152 0.097 NA 0.154 5.3e-07 1.5e-05 5.6e-04 NA 1.3e-05
8 TCGA Glioblastoma Multiforme 0.488 0.0840 3.4e-09 0.360 0.318 0.371 NA 0.422 8.1e-12 2.2e-10 3.4e-12 NA 3.9e-14
9 TCGA Head and Neck Squamous Cell Carcinoma 0.194 0.0393 0.0e+00 0.200 0.180 0.212 NA 0.217 4.9e-22 8.7e-20 2.2e-23 NA 6.1e-24
10 TCGA Kidney Renal Clear Cell Carcinoma 0.373 0.0429 0.0e+00 0.395 0.458 0.453 NA 0.452 2.4e-47 2.9e-57 2.4e-56 NA 2.5e-56
11 TCGA Kidney Renal Papillary Cell Carcinoma 0.128 0.0460 2.9e-04 0.132 0.073 0.094 NA 0.127 5.8e-08 5.7e-05 5.0e-06 NA 1.0e-07
12 TCGA Brain Lower Grade Glioma 0.241 0.0381 0.0e+00 0.325 0.319 0.358 NA 0.366 8.5e-38 5.2e-37 2.4e-42 NA 1.5e-43
13 TCGA Liver Hepatocellular Carcinoma 0.216 0.0650 7.6e-06 0.127 0.111 0.086 NA 0.139 1.5e-06 7.0e-06 7.4e-05 NA 4.7e-07
14 TCGA Lung Adenocarcinoma 0.415 0.0518 0.0e+00 0.364 0.370 0.381 NA 0.379 1.8e-44 2.4e-45 4.2e-47 NA 8.3e-47
15 TCGA Lung Squamous Cell Carcinoma 0.203 0.0349 0.0e+00 0.261 0.261 0.282 NA 0.285 1.6e-29 1.5e-29 3.3e-32 NA 1.5e-32
16 TCGA Ovarian Serous Cystadenocarcinoma 0.300 0.0600 9.4e-14 0.249 0.191 0.228 NA 0.258 6.0e-17 5.4e-13 1.8e-15 NA 1.4e-17
17 TCGA Pancreatic Adenocarcinoma 0.514 0.0750 0.0e+00 0.500 0.331 0.513 NA 0.520 8.6e-24 1.5e-14 1.2e-24 NA 4.3e-25
18 TCGA Pheochromocytoma and Paraganglioma 0.449 0.0710 5.4e-13 0.382 0.301 0.367 NA 0.403 3.0e-16 1.7e-12 1.8e-15 NA 2.8e-17
19 TCGA Prostate Adenocarcinoma 0.326 0.0517 0.0e+00 0.298 0.329 0.335 NA 0.331 1.6e-31 2.9e-35 4.9e-36 NA 1.6e-35
20 TCGA Soft Tissue Sarcoma 0.280 0.0570 5.4e-13 0.248 0.205 0.253 NA 0.251 6.9e-15 2.5e-12 3.2e-15 NA 4.3e-15
21 TCGA Skin Cutaneous Melanoma 0.372 0.1130 1.4e-03 0.077 0.132 0.043 NA 0.146 4.2e-03 2.1e-04 2.6e-02 NA 1.0e-04
22 TCGA Stomach Adenocarcinoma 0.215 0.0480 4.0e-14 0.263 0.222 0.261 NA 0.251 3.9e-19 5.0e-16 5.8e-19 NA 3.2e-18
23 TCGA Testicular Germ Cell Tumors 0.255 0.0770 7.3e-05 0.201 0.139 0.168 NA 0.192 1.2e-07 1.3e-05 1.5e-06 NA 2.3e-07
24 TCGA Thyroid Carcinoma 0.130 0.0340 2.3e-09 0.168 0.117 0.148 NA 0.164 3.9e-16 1.8e-11 2.9e-14 NA 1.1e-15
25 TCGA Uterine Corpus Endometrial Carcinoma 0.267 0.0990 8.1e-04 0.133 0.133 0.021 NA 0.065 1.6e-04 1.6e-04 8.3e-02 NA 6.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Bipolar Disorder (2018) 0.2 0.4 1.4 -1.0 0.1 0.2 0.4 0.5 0.4 0.7 0.7 0.3 0.7 0.0 0.5 0.9 0.6 0.2 0.4 0.9 0.4 0.4 0.7 -0.4 0.4 1.0 0.1 1.2
Bipolar Disorder or Schizophrenia 0.1 0.3 1.6 0.1 -0.2 -0.6 -0.5 0.0 -0.5 -0.3 -0.3 -0.8 -0.5 0.0 -0.3 0.3 -0.3 -0.5 -0.3 -0.3 -0.6 -0.4 -0.5 -1.1 -0.9 -0.2 -1.3 -0.1
Depressed Affect (Nagel 2018) 0.1 0.2 1.2 -0.5 0.0 0.1 0.3 -0.4 0.3 0.3 0.7 0.2 0.4 0.4 0.0 -0.3 0.3 0.1 0.3 0.5 0.1 0.0 0.3 -1.1 0.2 0.5 0.2 0.6
Depression (Nagel 2018) 0.7 1.0 3.0 -1.1 0.6 0.6 0.8 0.5 0.9 0.9 1.3 0.9 1.7 1.0 0.7 0.8 1.3 0.6 0.6 1.0 1.2 0.3 1.3 0.7 0.9 1.1 1.0 1.7
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.7 -0.1 -0.2 -0.6 -0.4 -0.5 -0.4 -0.3 -0.3 -0.3 0.1 -0.2 -0.5 -0.3 -0.3 -0.7 -0.6 0.0 -0.4 -0.5 -0.2 -0.9 -0.3 0.1 -0.2 0.1
Neuroticism (Nagel 2018) 0.3 0.6 2.4 -0.7 -0.1 0.5 0.7 -0.1 0.8 0.9 1.2 0.7 1.0 1.2 0.4 0.1 0.7 0.4 0.6 0.7 0.6 0.4 1.0 -0.6 0.8 0.7 0.8 1.5
Schizophrenia (2018) 0.5 1.0 2.9 1.0 -0.3 -1.0 -1.0 -0.4 -1.0 -1.0 -1.0 -1.3 -1.2 -1.1 -0.8 -0.3 -0.9 -0.8 -0.7 -1.0 -1.1 -0.9 -1.2 -1.0 -1.4 -1.0 -1.7 -1.0
Schizophrenia vs Biploar Disorder 0.7 0.9 1.8 1.3 -1.0 -0.8 -1.0 -1.1 -0.8 -1.1 -1.1 -0.6 -1.3 0.0 -1.0 -1.3 -0.7 -0.8 -1.2 -1.2 -0.5 -0.7 -0.8 -0.6 -0.7 -1.2 -0.1 -0.9
Worry (Nagel 2018) 0.3 0.7 3.7 -1.2 -0.0 0.2 0.5 0.0 0.8 1.0 1.4 0.5 1.1 1.2 0.3 0.4 1.0 0.2 0.4 1.0 0.5 0.1 0.9 0.1 0.7 1.1 0.3 1.9
Alzheimer’s Disease (in mother) 0.5 0.6 1.4 0.5 -0.4 -0.8 -0.8 -0.8 -0.7 -0.5 -0.6 -0.9 -1.2 -0.5 -0.8 -0.7 -0.9 -0.9 -0.4 -0.6 -1.0 -1.0 -0.7 -1.1 -0.6 -0.5 -1.0 -0.6
Alzheimer’s Disease (in father) 0.1 0.1 0.4 -0.3 -0.5 0.2 0.2 0.4 0.2 0.2 0.4 0.3 -0.2 0.3 0.4 0.5 0.4 0.3 0.1 0.3 0.5 0.1 0.5 0.1 0.2 0.3 0.4 0.6
Alzheimer’s Disease (including proxy) 0.2 0.3 1.2 0.1 -0.7 -0.7 -0.6 -0.3 -0.4 -0.2 -0.2 -0.6 -1.1 -0.1 -0.4 -0.0 -0.5 -0.7 -0.5 -0.3 -0.5 -0.7 -0.3 -0.8 -0.4 -0.1 -0.7 -0.2
Crohns Disease (2017) 0.2 0.3 1.1 -0.7 0.2 0.3 0.3 0.7 0.5 0.7 0.9 0.2 1.0 0.7 0.5 0.9 0.2 0.3 0.5 0.6 0.2 0.2 0.4 -0.7 0.2 0.7 -0.2 1.0
Irritable Bowel Disease (IBD) 0.1 0.3 1.1 -0.6 -0.2 0.1 0.1 0.4 0.4 0.6 1.0 0.0 0.8 0.6 0.3 0.6 0.2 0.1 0.5 0.5 -0.1 0.1 0.2 -0.9 0.1 0.5 -0.3 1.0
Ulcerative Colitis (UC) 0.1 0.1 1.2 -0.0 -0.7 -0.3 -0.2 -0.3 -0.1 -0.0 0.5 -0.2 0.2 0.0 -0.3 -0.2 -0.2 -0.3 -0.1 -0.0 -0.3 -0.2 -0.2 -1.1 -0.1 -0.1 -0.3 0.5
Major Depression (MDD) 0.5 0.6 1.1 0.5 -1.0 -0.9 -0.8 -1.1 -0.7 -0.7 -0.5 -0.7 -0.7 -0.6 -0.9 -1.0 -0.7 -0.9 -0.8 -0.5 -0.8 -0.7 -0.7 -0.6 -0.8 -0.5 -0.8 -0.3
Reaction Time 1.7 3.3 4.2 -1.9 2.0 1.7 1.8 1.5 1.9 1.9 1.9 1.8 2.0 2.0 1.7 1.6 1.7 1.5 1.8 1.9 1.8 1.8 1.9 1.2 2.0 1.9 1.8 2.1
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.6 -0.9 1.6 0.6 0.9 0.9 0.6 0.7 0.7 0.6 1.1 0.6 0.9 1.1 0.8 0.7 0.4 0.9 0.8 0.8 0.8 0.4 0.7 0.9 0.5 0.6
Breast Cancer 1.3 3.2 5.1 1.6 -2.0 -1.9 -1.9 -1.6 -1.8 -1.8 -1.8 -1.9 -1.4 -1.8 -1.8 -1.5 -2.2 -1.9 -1.9 -1.8 -1.9 -2.3 -1.8 -1.3 -2.0 -1.6 -1.9 -1.2
Ovarian Cancer 0.1 0.1 0.3 0.3 -0.6 -0.1 -0.2 -0.3 -0.2 -0.2 0.2 -0.0 -0.2 -0.2 -0.3 -0.4 -0.6 -0.2 -0.3 -0.2 -0.2 0.4 -0.3 -0.4 -0.3 -0.1 0.1 -0.5
Prostate Cancer 0.1 0.1 0.4 0.4 0.0 -0.4 -0.2 -0.5 -0.4 -0.5 -0.0 -0.2 -0.4 -0.4 -0.5 -0.6 -0.4 -0.4 -0.4 -0.3 -0.1 -0.4 -0.3 0.2 -0.4 -0.4 0.2 0.3
Age at First Birth 3.6 5.2 9.4 -2.0 3.0 2.2 2.3 3.0 2.1 2.2 2.1 2.0 1.7 2.1 2.6 3.1 2.3 2.4 2.4 2.1 2.1 2.5 2.0 2.9 1.9 1.9 1.6 1.4
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.1 -0.2 -0.3 -0.2 -0.3 -0.1 0.1 0.0 -0.3 0.0 0.0 -0.2 -0.1 -0.5 -0.4 0.0 0.0 -0.4 -0.1 -0.1 0.0 -0.1 0.1 -0.4 0.2
Body Mass Index (BMI) (2010) 1.2 1.6 2.5 -1.4 0.8 1.2 1.3 1.1 1.3 1.3 1.0 1.5 1.3 1.4 1.2 1.1 1.1 1.2 0.9 1.4 1.3 1.3 1.4 1.5 1.5 1.3 1.6 0.9
Coronary Artery Disease (CAD) 0.2 0.2 1.0 -0.8 0.4 0.2 0.2 0.1 0.7 1.0 1.0 0.1 -0.2 0.0 0.2 0.3 0.3 0.1 0.6 0.7 -0.1 0.3 0.5 0.0 0.2 0.8 -0.3 0.7
Crohns Disease (2012) 0.1 0.2 1.0 -0.6 0.6 0.2 0.1 0.9 0.3 0.4 0.6 0.1 0.6 0.3 0.5 1.0 0.1 0.1 0.0 0.5 0.1 0.1 0.1 -0.4 -0.0 0.6 -0.4 0.6
Mean Putamen Volume 0.0 0.0 0.2 0.1 -0.3 -0.0 -0.2 -0.3 -0.1 -0.1 -0.1 -0.2 0.2 0.0 -0.2 -0.3 -0.4 -0.1 0.2 -0.1 -0.4 -0.1 -0.2 0.2 -0.2 -0.1 -0.2 -0.2
Fasting Glucose 0.3 0.4 2.0 -1.4 0.2 0.1 0.2 0.0 0.4 0.6 0.5 0.4 0.8 0.7 0.1 0.2 0.4 0.0 -0.1 1.3 0.2 0.3 0.5 0.6 0.3 1.4 0.3 0.8
HbA1C 1.6 1.8 4.1 -1.9 1.3 1.3 1.4 1.5 1.3 1.2 1.1 1.3 1.2 1.1 1.3 1.4 0.9 1.3 1.2 1.9 1.4 1.6 1.2 1.0 1.1 2.0 1.0 0.5
HDL Cholesterol 0.0 0.0 0.2 -0.1 -0.4 -0.0 -0.0 -0.3 -0.0 0.2 -0.1 0.0 -0.1 0.2 -0.1 -0.2 -0.4 -0.1 0.2 0.1 -0.3 -0.1 -0.0 -0.2 0.1 0.2 -0.0 0.2
LDL Cholesterol 0.1 0.1 1.2 -0.2 -0.2 0.0 0.0 0.1 0.1 0.1 0.6 0.3 0.3 0.1 0.1 0.2 -0.2 -0.0 -0.2 0.2 0.5 -0.0 0.4 0.3 0.1 0.2 0.5 1.1
Lupus 0.2 0.4 1.0 -0.8 0.5 0.5 0.5 0.3 0.6 0.6 0.8 0.5 0.8 0.6 0.5 0.4 0.7 0.5 0.5 0.7 0.6 0.7 0.6 1.0 0.5 0.7 0.6 0.3
Neuroticism (2016) 0.2 0.3 0.9 -0.3 0.7 0.4 0.4 1.0 0.4 0.4 0.9 0.4 0.2 0.3 0.5 0.9 0.0 0.2 0.3 0.5 0.6 0.8 0.4 -0.5 0.2 0.5 0.4 0.4
Primary Biliary Cirrhosis 1.9 2.7 3.6 -1.8 1.6 1.5 1.7 1.5 1.7 1.7 1.9 1.6 1.9 1.7 1.5 1.5 1.7 1.5 1.8 1.9 1.6 1.4 1.7 1.5 1.6 1.9 1.4 1.4
Rheumatoid Arthritis 1.4 1.9 2.8 -1.3 1.2 1.4 1.4 1.4 1.4 1.3 1.5 1.4 1.7 1.3 1.4 1.3 1.4 1.4 1.2 1.3 1.6 1.0 1.5 1.1 1.4 1.3 1.4 1.4
Schizophrenia (2014) 0.0 0.1 0.4 0.0 0.3 0.1 0.0 0.4 0.0 0.1 0.4 -0.3 -0.5 0.0 0.2 0.5 0.2 0.3 0.5 -0.2 -0.1 0.0 -0.1 -0.1 -0.2 -0.1 -0.7 -0.2
Triglycerides 0.2 0.4 1.4 0.8 -0.2 -0.5 -0.6 0.2 -0.5 -0.6 -0.3 -0.7 -1.2 -0.7 -0.3 0.1 -0.9 -0.4 -0.4 -0.6 -0.4 -0.2 -0.7 0.5 -0.9 -0.6 -0.9 -0.6
Type 2 Diabetes (T2D) (2012) 1.7 1.9 3.8 -1.6 1.4 1.4 1.5 0.6 1.4 1.5 1.0 1.7 1.1 1.7 1.1 0.5 1.4 1.2 1.4 1.5 1.4 1.5 1.6 1.2 1.6 1.5 2.0 1.2
Ulcerative Colitis 0.0 0.1 0.2 -0.0 -0.3 -0.2 -0.3 -0.1 -0.2 -0.0 0.2 -0.2 -0.5 0.0 -0.2 -0.1 0.0 -0.3 -0.0 -0.1 -0.4 -0.1 -0.3 -0.3 -0.2 -0.1 -0.3 0.3
Blood Eosinophil Count 0.3 2.7 7.6 1.9 -1.4 -1.3 -1.5 -1.1 -1.7 -2.0 -1.5 -1.5 -2.2 -2.1 -1.4 -1.3 -1.3 -1.2 -1.7 -1.8 -1.2 -1.3 -1.7 -0.7 -1.9 -1.9 -1.3 -2.8
Blood Platelet Count 2.1 23.9 26.7 -4.9 5.2 5.1 5.0 5.0 5.2 5.2 5.0 4.9 5.0 5.1 5.2 5.0 5.0 5.1 4.9 4.9 5.0 4.4 5.0 3.8 4.9 4.9 4.5 3.9
Blood Red Count 2.3 22.2 26.7 4.4 -5.0 -5.0 -5.1 -5.0 -4.8 -4.6 -4.2 -4.8 -4.9 -4.5 -5.0 -4.9 -4.7 -5.1 -4.8 -4.5 -5.1 -5.2 -4.8 -3.9 -4.7 -4.3 -4.6 -3.5
Blood White Count 1.7 12.4 16.4 3.8 -2.7 -3.5 -3.7 -2.9 -3.7 -3.9 -4.0 -3.7 -3.2 -4.0 -3.4 -3.0 -3.5 -3.4 -3.9 -3.7 -3.5 -3.5 -3.8 -2.4 -3.9 -3.8 -3.8 -2.7
Heel T-Score 0.0 0.1 0.5 0.1 -0.6 -0.1 -0.3 0.4 -0.1 -0.1 -0.1 -0.1 -0.7 0.0 0.1 0.4 -0.4 -0.4 -0.3 -0.2 -0.0 -0.2 -0.0 0.4 -0.1 -0.0 -0.1 -0.7
BMI 1.6 9.1 18.3 2.9 -2.0 -2.9 -3.1 -2.5 -3.0 -2.9 -2.5 -3.1 -3.9 -2.9 -2.7 -2.5 -3.2 -2.9 -3.1 -3.0 -3.3 -2.6 -3.2 -2.4 -3.3 -2.9 -3.2 -4.3
Height 0.0 0.9 3.9 -0.7 -0.0 0.9 0.9 0.7 1.0 0.9 1.0 0.9 0.8 0.9 0.8 0.7 0.2 0.9 1.3 0.6 1.0 1.2 0.9 0.6 0.9 0.7 1.0 2.0
Waist Hip Ratio (WHR) 0.0 0.1 0.6 -0.3 0.8 0.2 0.1 0.2 0.3 0.4 0.0 0.1 0.3 0.3 0.1 0.1 -0.4 0.2 0.6 0.3 -0.1 0.4 0.0 0.4 0.0 0.3 -0.1 0.2
Systolic Blood Pressure 2.1 10.6 13.2 3.2 -2.9 -3.2 -3.4 -3.2 -3.2 -3.3 -3.4 -3.1 -3.6 -3.3 -3.4 -3.4 -3.3 -3.3 -3.4 -3.2 -3.4 -2.8 -3.4 -2.9 -3.3 -3.2 -2.9 -3.6
Smoking Status 0.4 1.1 2.9 1.1 -1.0 -1.1 -1.0 -1.1 -1.1 -1.1 -0.8 -1.0 -1.0 -1.0 -1.1 -1.1 -0.8 -1.1 -1.2 -1.0 -0.9 -0.8 -0.9 -1.2 -0.9 -1.0 -0.7 -1.7
Allergy or Eczema 1.0 2.5 5.5 -1.9 0.9 1.3 1.5 1.0 1.6 1.7 2.3 1.7 1.9 1.8 1.3 1.2 1.5 1.4 1.2 1.8 1.8 1.3 2.0 0.2 1.9 1.9 1.9 0.9
Cardiovascular Disease 4.0 13.3 17.5 3.6 -3.4 -3.8 -3.8 -3.4 -3.6 -3.7 -3.3 -3.9 -4.1 -3.7 -3.6 -3.4 -3.6 -3.6 -3.8 -3.6 -3.7 -3.5 -3.8 -3.1 -4.2 -3.6 -4.1 -2.9
Hypothyroidism (self reported) 0.5 1.1 2.5 -1.6 1.2 1.1 1.0 1.0 1.1 1.3 0.9 1.1 1.0 1.2 1.1 1.1 0.6 0.9 1.3 1.4 0.7 0.7 1.0 0.9 0.9 1.6 0.8 0.7
Respiratory disease 0.5 1.1 3.8 -0.6 2.0 1.2 1.1 1.5 1.1 0.8 0.4 0.8 0.4 0.6 1.2 1.3 0.9 1.5 1.1 0.7 1.1 1.2 0.7 1.9 0.7 0.5 0.5 -0.4
Type 2 Diabetes (T2D) (2018) 2.5 4.6 7.3 1.8 -2.3 -2.2 -2.3 -2.4 -2.2 -1.8 -1.5 -2.1 -2.7 -1.7 -2.3 -2.2 -2.7 -2.5 -2.4 -1.8 -2.6 -1.9 -2.2 -1.7 -2.2 -1.7 -2.0 -1.9
Lung FEV1/FVC ratio 2.7 13.9 17.7 3.7 -3.7 -3.9 -4.0 -3.7 -3.9 -3.7 -3.3 -3.8 -3.7 -3.6 -3.8 -3.6 -4.2 -4.0 -3.8 -3.8 -3.8 -3.7 -3.7 -4.0 -3.9 -3.5 -3.5 -2.4
Lung FVC 1.1 5.4 8.7 2.4 -2.1 -2.4 -2.4 -2.3 -2.4 -2.3 -3.0 -2.3 -1.9 -2.3 -2.3 -2.2 -2.5 -2.5 -2.8 -2.3 -2.3 -2.5 -2.2 -1.7 -2.2 -2.3 -2.0 -2.0
Neuroticism 0.6 1.4 4.1 -1.5 0.9 1.0 1.1 0.5 1.2 1.4 1.8 1.1 1.2 1.6 0.8 0.6 1.2 0.8 1.0 1.5 0.8 1.1 1.2 -0.3 1.1 1.6 1.0 2.0
Chronotype (morning person) 3.5 8.0 11.6 -2.4 2.7 3.0 3.0 2.5 2.9 2.7 2.6 3.1 3.3 2.7 2.8 2.4 3.4 3.0 2.6 2.5 3.2 2.8 3.0 2.8 3.0 2.3 3.3 2.4
Hair Pigment 0.0 0.6 1.3 0.6 -0.6 -0.7 -0.7 -0.6 -0.7 -0.7 -0.5 -0.8 -1.1 -0.7 -0.7 -0.5 -1.0 -0.6 -0.4 -0.7 -0.9 -0.8 -0.8 -0.6 -0.9 -0.6 -1.0 -0.6
Tanning 0.0 0.3 1.8 0.2 0.7 0.4 0.4 0.7 0.3 0.1 0.1 0.4 0.7 -0.1 0.4 0.5 1.1 0.5 0.3 -0.1 0.9 0.6 0.4 1.4 0.3 -0.3 0.6 -0.0
Hand grip strength (left) 1.7 4.4 7.4 2.2 -2.5 -1.8 -1.9 -2.1 -2.1 -2.2 -2.3 -1.9 -2.7 -2.2 -2.0 -2.3 -1.7 -1.8 -2.0 -2.1 -2.0 -2.1 -2.1 -1.6 -2.1 -2.0 -1.7 -2.3
Number of treatments/medications taken 0.1 0.2 0.9 0.4 0.1 -0.5 -0.4 -0.5 -0.3 -0.4 -0.2 -0.5 -0.1 -0.4 -0.5 -0.5 -0.3 -0.4 -0.6 -0.4 -0.3 -0.1 -0.3 -1.0 -0.6 -0.4 -0.4 0.1
Average weekly spirits intake 0.1 0.1 1.7 0.0 0.6 0.0 0.1 0.2 -0.0 0.1 0.3 -0.2 -0.6 -0.0 0.2 0.3 -0.3 0.2 0.4 -0.0 -0.2 0.2 -0.1 0.3 0.0 0.0 -0.5 -1.3
Sensitivity / hurt feelings 1.9 3.3 6.5 -1.8 1.4 1.9 1.9 1.4 1.9 1.8 2.1 2.0 1.2 1.9 1.7 1.3 1.7 1.7 1.8 1.9 1.7 2.0 1.8 1.0 1.9 1.9 2.1 2.6
Frequency of depressed mood in last 2 weeks 1.1 1.5 3.2 -1.4 0.9 0.9 1.1 0.7 1.2 1.3 1.4 1.2 1.8 1.4 1.0 1.0 1.7 0.8 0.9 1.3 1.3 0.6 1.6 0.5 1.4 1.4 1.4 1.5
Hearing difficulty/problems: Yes 0.7 1.1 2.3 -0.9 1.5 1.1 1.1 1.4 1.0 1.1 0.9 1.0 1.0 1.0 1.2 1.3 0.6 1.1 1.0 0.9 1.1 0.7 1.0 0.4 1.0 0.9 1.0 0.6
Relative age of first facial hair 0.1 0.2 0.4 0.4 -0.4 -0.5 -0.4 -0.4 -0.6 -0.6 -0.1 -0.4 -0.1 -0.6 -0.4 -0.3 -0.4 -0.3 -0.5 -0.4 -0.3 -0.6 -0.4 -0.0 -0.4 -0.5 -0.2 -0.4
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.1 -0.8 0.8 0.1 0.3 -0.2 0.3 0.4 1.0 0.4 0.4 0.5 0.1 0.0 0.5 0.1 0.3 0.7 0.4 0.2 0.5 -0.6 0.3 0.7 0.5 1.0
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.3 -0.9 0.9 1.0 1.2 0.7 1.1 1.0 0.8 1.2 0.9 1.1 0.9 0.6 1.2 1.0 1.1 0.9 1.4 1.0 1.3 0.6 1.2 0.9 1.5 1.4
Ever had hysterectomy (womb removed) 8.1 9.1 11.6 2.9 -2.2 -3.1 -3.1 -2.9 -3.0 -2.8 -3.0 -3.1 -3.4 -2.8 -3.1 -2.9 -3.3 -3.2 -2.8 -2.9 -3.4 -3.3 -3.2 -2.9 -3.2 -2.8 -3.2 -2.8
Systolic blood pressure, automated reading 0.7 2.0 4.0 1.3 -1.0 -1.3 -1.4 -1.3 -1.3 -1.2 -1.0 -1.4 -1.8 -1.3 -1.4 -1.4 -1.5 -1.4 -1.3 -1.2 -1.7 -0.9 -1.6 -2.0 -1.6 -1.2 -1.6 -1.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.0 -0.4 -0.5 -0.3 -0.2 -0.5 -0.3 0.3 -0.3 -0.2 -0.2 -0.2 0.0 0.0 -0.5 -0.4 -0.0 -0.4 -0.1 -0.3 0.4 -0.2 0.0 -0.3 -0.6
Angina 1.2 1.6 2.2 1.2 -1.3 -1.2 -1.2 -1.4 -1.3 -1.4 -0.9 -1.3 -1.4 -1.5 -1.3 -1.5 -0.8 -1.2 -1.2 -1.2 -1.3 -1.1 -1.4 -0.9 -1.4 -1.3 -1.2 -1.0
Medication for hormone replacement therapy 5.5 6.1 9.6 -2.5 2.1 2.7 2.7 2.2 2.6 2.6 2.1 2.9 2.4 2.6 2.4 2.0 2.3 2.5 2.5 2.6 2.6 2.6 2.7 2.0 2.8 2.5 3.1 1.2
Vitamin and mineral supplements 0.7 1.0 1.9 1.0 -1.0 -0.9 -1.0 -0.7 -1.0 -1.0 -1.1 -1.0 -1.1 -1.0 -0.9 -0.7 -0.9 -0.9 -1.1 -1.0 -1.0 -1.4 -1.1 -1.0 -1.1 -1.0 -1.1 -0.7
Supplements: Zinc 0.2 0.2 1.1 0.4 -1.0 -0.3 -0.3 -0.7 -0.2 -0.4 0.2 -0.1 -0.4 -0.4 -0.4 -0.7 -0.4 -0.2 -0.1 -0.4 0.0 -0.6 -0.2 -0.8 -0.0 -0.4 0.2 0.5
Medication: Co-codamol 0.1 0.1 0.5 0.2 -0.6 -0.3 -0.2 -0.5 -0.2 -0.3 -0.4 -0.3 -0.2 -0.3 -0.4 -0.5 -0.2 -0.3 -0.3 -0.2 -0.3 -0.7 -0.3 -0.5 -0.3 -0.2 -0.3 0.3
Medication: Metformin 0.2 0.3 0.7 -0.4 0.5 0.5 0.5 0.7 0.4 0.7 0.2 0.5 0.5 0.7 0.6 0.9 0.3 0.4 0.5 0.5 0.3 0.7 0.5 0.4 0.6 0.5 0.5 -0.6
Diabetes (father) 1.5 1.8 3.2 -1.4 1.5 1.3 1.4 1.1 1.3 1.3 0.4 1.5 1.7 1.3 1.3 1.2 1.4 1.3 1.1 1.4 1.5 1.0 1.5 0.3 1.5 1.4 1.6 1.8
Diabetes (mother) 1.1 1.4 2.6 -1.3 1.4 1.0 1.1 1.0 1.2 1.3 0.8 1.2 1.1 1.3 1.0 1.2 1.1 1.0 1.1 1.3 1.2 1.4 1.3 0.2 1.4 1.3 1.2 1.6
Severe depression (siblings) 1.9 2.1 3.5 -1.1 1.5 1.5 1.5 1.8 1.6 1.5 1.3 1.4 1.4 1.4 1.7 1.9 1.4 1.5 1.4 1.2 1.6 1.3 1.5 1.4 1.5 1.2 1.2 1.7
Pack years adult smoking proportion 0.0 0.1 0.6 -0.0 0.6 0.1 0.2 0.2 0.2 0.0 0.3 0.1 0.7 -0.0 0.2 0.3 0.4 0.3 -0.1 0.0 0.4 0.2 0.2 0.1 0.2 0.0 0.1 -0.1
Impedance of leg (right) 0.8 3.7 6.3 1.9 -2.5 -2.2 -2.1 -2.0 -2.0 -1.9 -1.7 -2.0 -1.7 -1.9 -2.2 -2.0 -1.8 -2.1 -1.7 -1.9 -1.9 -2.3 -1.9 -1.2 -1.8 -2.0 -1.9 -0.4
Leg fat-free mass (left) 0.0 0.2 0.9 -0.4 1.0 0.6 0.5 0.6 0.5 0.4 -0.0 0.3 0.3 0.4 0.6 0.5 0.2 0.6 0.4 0.4 0.3 1.0 0.3 0.0 0.2 0.5 0.1 -0.9
Trunk fat percentage 1.3 5.4 11.5 2.0 -1.3 -2.2 -2.4 -1.8 -2.4 -2.3 -2.5 -2.5 -2.8 -2.4 -2.0 -1.8 -2.4 -2.2 -2.2 -2.1 -2.6 -1.9 -2.6 -2.0 -2.5 -2.0 -2.7 -3.4
Hand grip strength (right) 2.5 6.8 12.3 2.5 -3.0 -2.5 -2.6 -2.3 -2.6 -2.7 -2.5 -2.6 -3.5 -2.7 -2.5 -2.4 -2.3 -2.5 -2.5 -2.5 -2.7 -2.7 -2.7 -1.4 -2.8 -2.4 -2.6 -2.9
Townsend deprivation index at recruitment 4.2 5.9 10.0 3.0 -2.0 -2.2 -2.5 -1.1 -2.5 -2.6 -2.8 -2.8 -2.4 -2.9 -1.9 -1.2 -2.7 -2.1 -2.3 -2.8 -2.4 -2.0 -2.8 -0.8 -2.9 -2.9 -3.2 -2.3
Current tobacco smoking 0.1 0.1 0.6 0.1 -0.2 -0.0 0.1 -0.4 -0.1 -0.1 0.1 0.2 0.5 -0.0 -0.2 -0.4 -0.0 -0.1 -0.1 -0.0 0.2 0.4 0.2 -0.8 0.4 -0.1 0.7 0.1
Average weekly fortified wine intake 0.4 0.5 1.4 0.6 -0.5 -0.4 -0.6 -0.6 -0.6 -0.6 -0.6 -0.6 -0.3 -0.7 -0.6 -0.7 -0.6 -0.5 -0.8 -0.7 -0.7 -0.8 -0.8 0.6 -0.7 -0.7 -0.7 -1.2
Maternal smoking around birth 0.2 0.3 1.7 -0.6 -0.1 0.3 0.3 -0.0 0.5 0.6 1.1 0.4 0.4 0.6 0.2 0.0 0.5 0.2 0.5 0.5 0.2 -0.1 0.4 0.6 0.4 0.5 0.3 1.3
Fed-up feelings 0.7 1.2 3.3 -1.1 1.1 1.1 1.2 1.1 1.1 1.2 1.8 0.9 0.9 1.2 1.2 1.2 1.1 1.1 1.5 1.1 0.9 1.1 1.1 -0.2 1.0 1.2 0.7 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 3.9 -1.2 1.0 1.0 1.2 0.8 1.3 1.2 1.1 1.2 1.5 1.3 1.1 1.0 2.0 1.0 1.2 1.1 1.5 0.9 1.5 1.7 1.4 1.1 1.3 1.6
Relative age voice broke 0.2 0.3 1.0 0.4 -0.6 -0.7 -0.5 -0.8 -0.6 -0.6 -0.0 -0.5 -0.2 -0.5 -0.7 -0.8 0.1 -0.5 -0.5 -0.5 -0.5 -1.0 -0.4 -0.1 -0.4 -0.5 -0.3 -0.6
Taking other prescription medications 0.4 0.7 1.4 -1.1 1.2 0.6 0.8 0.6 0.8 0.9 0.9 0.7 0.8 0.9 0.7 0.8 0.5 0.6 0.7 1.1 0.7 1.0 0.9 -0.6 0.6 1.1 0.7 0.7
Age when periods started (menarche) 0.1 0.2 0.9 0.1 -0.9 -0.5 -0.2 -0.6 -0.2 -0.1 0.2 -0.0 0.8 0.0 -0.4 -0.5 -0.0 -0.3 -0.6 -0.1 0.1 -0.1 0.2 -0.9 0.2 -0.1 0.4 0.6
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 2.1 1.0 -1.1 -1.1 -1.0 -1.3 -1.0 -1.0 -1.0 -1.0 -1.4 -0.9 -1.1 -1.2 -1.4 -1.2 -1.0 -1.0 -1.0 -0.9 -1.0 -1.3 -1.0 -0.9 -0.9 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 2.1 -0.0 -0.6 -0.2 -0.2 -0.8 -0.1 -0.1 0.2 0.1 -0.4 0.1 -0.3 -0.7 -0.5 -0.2 -0.4 -0.1 -0.2 -0.4 0.1 -1.4 0.1 0.1 0.3 0.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.8 0.8 0.3 -0.4 -0.4 -0.1 -0.3 -0.5 -0.6 -0.4 -0.6 -0.5 -0.4 -0.3 -0.0 -0.4 -0.7 -0.6 -0.4 -0.2 -0.7 -0.2 -0.5 -0.7 -0.4 -1.3
Qualifications: CSEs or equivalent 0.4 0.5 1.0 -0.9 0.5 0.8 0.8 -0.2 0.8 0.9 0.8 0.9 0.7 1.0 0.4 -0.2 0.8 0.8 0.9 0.9 0.4 0.7 0.7 -0.0 0.9 0.8 1.0 -0.3
Serious illness, injury or assault to yourself 0.7 0.9 2.0 -0.8 1.4 0.9 0.9 1.0 0.9 0.7 1.1 0.9 1.0 0.7 1.0 1.0 1.4 1.0 0.7 0.7 1.2 1.1 1.0 0.9 0.9 0.6 0.9 0.4
High blood pressure 1.5 4.2 8.1 2.0 -1.4 -2.0 -2.1 -1.9 -1.9 -1.8 -1.9 -2.4 -2.3 -1.9 -2.0 -1.9 -2.0 -1.9 -1.8 -2.1 -2.5 -1.5 -2.3 -1.7 -2.5 -2.1 -2.8 -1.5
Hayfever, allergic rhinitis or eczema 1.5 3.3 5.5 -2.1 1.2 1.5 1.8 1.1 1.8 1.9 2.0 2.0 2.3 2.0 1.5 1.3 1.9 1.6 1.6 2.1 2.0 1.6 2.2 -0.1 2.3 2.1 2.2 1.4
Multivitamins +/- minerals 0.0 0.0 0.2 0.0 0.3 -0.1 -0.0 -0.3 0.0 0.0 0.2 0.0 -0.1 0.1 -0.1 -0.2 0.4 -0.1 -0.1 -0.0 0.1 -0.0 0.2 0.2 0.1 -0.0 0.2 -0.4
Stomach or abdominal pain in last month 0.1 0.2 1.2 -0.3 -0.2 0.0 0.1 0.5 0.1 0.0 0.2 0.3 0.2 0.2 0.3 0.5 0.3 0.1 -0.2 0.2 0.8 -0.1 0.6 0.8 0.4 0.2 0.6 1.1
Supplements: Glucosamine 4.2 5.4 8.5 -2.0 2.2 2.4 2.4 2.4 2.5 2.2 1.6 2.6 2.9 2.2 2.4 2.2 2.3 2.4 1.9 2.1 2.9 2.5 2.6 2.2 2.6 2.1 2.9 1.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 3.3 -0.5 0.1 0.4 0.4 0.2 0.4 0.6 0.5 0.6 1.1 0.7 0.5 0.4 0.4 0.2 0.1 0.4 0.4 0.3 0.7 0.1 0.7 0.5 0.7 1.8
Medication: Atenolol 2.0 2.5 4.0 1.8 -1.6 -1.6 -1.6 -1.2 -1.7 -1.8 -1.4 -1.6 -1.7 -1.9 -1.5 -1.3 -1.5 -1.5 -2.0 -1.7 -1.4 -1.5 -1.6 -1.3 -1.7 -1.8 -1.3 -1.4
Medication: Levothyroxine sodium 0.3 0.4 1.2 -1.1 0.0 0.5 0.4 -0.2 0.6 0.7 0.9 0.7 0.7 0.9 0.3 -0.1 0.4 0.4 0.9 0.8 0.2 -0.1 0.7 -0.4 0.8 1.0 0.8 0.9
Sitting height 0.1 0.4 0.8 0.4 -0.6 -0.7 -0.5 -0.5 -0.6 -0.4 -0.8 -0.7 -0.8 -0.5 -0.6 -0.4 -0.7 -0.7 -0.3 -0.4 -0.9 -0.4 -0.7 0.3 -0.9 -0.3 -0.9 -0.5
Chronic bronchitis/emphysema (father) 0.2 0.2 2.3 0.0 0.0 -0.4 -0.4 -0.6 -0.4 -0.2 -0.5 -0.5 -0.3 -0.1 -0.4 -0.4 -0.6 -0.6 -0.2 -0.0 -0.6 -0.1 -0.3 -1.5 -0.2 0.1 -0.7 0.6
High blood pressure (mother) 2.4 3.4 5.7 1.6 -1.6 -2.0 -2.0 -1.9 -1.9 -1.8 -1.5 -2.0 -1.6 -1.8 -2.0 -1.8 -2.4 -2.0 -1.9 -1.7 -2.1 -1.8 -2.0 -1.7 -2.1 -1.6 -2.0 -0.8
Body mass index (BMI) 0.3 1.3 5.7 0.9 -0.2 -0.7 -1.0 -0.5 -1.0 -1.0 -1.4 -1.2 -1.4 -1.1 -0.7 -0.7 -1.2 -0.8 -1.0 -0.9 -1.2 -0.7 -1.3 -1.2 -1.3 -0.8 -1.4 -2.4
Impedance of leg (left) 0.8 4.1 6.5 2.0 -2.6 -2.3 -2.2 -1.9 -2.1 -2.1 -1.9 -2.1 -2.0 -2.1 -2.2 -1.9 -1.9 -2.2 -1.9 -2.1 -2.0 -2.4 -2.1 -0.9 -2.0 -2.1 -2.0 -0.8
Leg predicted mass (left) 0.0 0.2 1.0 -0.3 0.9 0.6 0.5 0.5 0.4 0.4 -0.0 0.3 0.3 0.3 0.6 0.4 0.2 0.6 0.4 0.4 0.2 0.9 0.2 -0.0 0.2 0.5 0.1 -1.0
Trunk fat mass 0.8 3.3 9.0 1.6 -0.9 -1.6 -1.8 -1.3 -1.8 -1.8 -2.1 -1.9 -2.2 -1.9 -1.5 -1.4 -2.0 -1.6 -1.6 -1.6 -2.1 -1.3 -2.1 -1.8 -2.0 -1.5 -2.1 -3.0
Waist circumference 0.6 2.3 7.2 1.4 -0.7 -1.2 -1.5 -1.1 -1.4 -1.4 -1.8 -1.5 -1.7 -1.5 -1.3 -1.3 -1.9 -1.3 -1.2 -1.4 -1.7 -0.9 -1.7 -1.8 -1.7 -1.3 -1.7 -2.7
Number of incorrect matches in round 0.1 0.1 1.3 0.0 0.6 -0.2 -0.1 0.2 -0.0 0.1 0.6 -0.2 -0.1 0.1 -0.1 0.3 -0.0 -0.2 -0.1 0.0 -0.2 0.6 -0.2 1.2 -0.1 -0.1 -0.4 -0.3
Past tobacco smoking 0.1 0.2 0.8 -0.2 0.5 0.7 0.5 0.6 0.5 0.3 -0.1 0.6 0.4 0.3 0.5 0.4 0.2 0.6 0.4 0.4 0.5 0.9 0.3 0.5 0.5 0.3 0.6 0.4
Alcohol usually taken with meals 0.3 0.5 1.4 -0.5 0.7 0.7 0.6 0.6 0.7 0.7 0.7 0.7 0.6 0.7 0.7 0.6 0.9 0.6 0.7 0.5 0.8 0.4 0.7 1.2 0.9 0.4 0.9 0.2
Nervous feelings 0.2 0.4 0.7 0.5 -0.7 -0.7 -0.7 -0.7 -0.5 -0.6 -0.7 -0.7 -0.4 -0.6 -0.7 -0.6 -0.4 -0.7 -0.7 -0.5 -0.6 -0.3 -0.6 -0.8 -0.7 -0.5 -0.8 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.9 -0.9 0.3 0.5 0.7 -0.0 0.9 0.9 1.1 0.9 1.1 1.0 0.3 0.1 1.4 0.4 0.5 0.9 0.8 0.3 1.0 0.5 0.8 0.9 1.1 0.2
Hearing difficulty/problems with background noise 0.5 0.8 1.6 -0.5 1.1 1.0 1.0 0.6 0.9 0.8 0.7 1.0 1.2 0.8 0.9 0.6 0.9 1.0 0.8 0.6 1.1 0.5 1.0 -0.4 1.2 0.6 1.3 0.8
Hair/balding pattern: Pattern 2 0.4 0.5 2.0 0.7 -1.0 -0.7 -0.5 -1.0 -0.6 -0.8 -0.8 -0.5 0.0 -0.7 -0.7 -0.9 -0.2 -0.6 -0.8 -0.7 -0.5 -0.8 -0.5 -1.4 -0.5 -0.7 -0.2 -0.5
Had menopause 1.3 1.6 2.5 1.6 -0.5 -1.2 -1.3 -0.6 -1.3 -1.2 -1.4 -1.4 -1.5 -1.3 -1.1 -0.7 -1.5 -1.2 -1.1 -1.5 -1.4 -0.8 -1.5 0.0 -1.5 -1.5 -1.5 -1.3
Had other major operations 0.2 0.2 1.2 0.2 -0.3 -0.3 -0.2 -1.0 -0.3 -0.3 -0.4 -0.3 -0.4 -0.2 -0.6 -1.1 -0.3 -0.3 0.0 -0.2 -0.6 -0.4 -0.4 -0.3 -0.2 -0.2 -0.2 -0.5
Forced vital capacity (FVC) 0.1 0.4 1.0 0.4 -0.5 -0.5 -0.5 -0.7 -0.6 -0.6 -1.0 -0.6 -0.6 -0.6 -0.6 -0.7 -0.4 -0.6 -0.6 -0.4 -0.7 -0.7 -0.6 0.3 -0.6 -0.3 -0.7 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 1.2 -0.5 0.1 0.7 0.5 0.1 0.6 0.5 0.4 0.8 -0.1 0.6 0.5 0.1 0.2 0.6 0.2 0.5 0.6 0.3 0.6 -0.9 0.7 0.6 1.1 0.2
Ever unenthusiastic/disinterested for a whole week 2.1 2.5 4.2 -1.7 2.0 1.5 1.4 2.0 1.6 1.6 1.5 1.4 1.7 1.5 1.7 2.0 1.5 1.4 1.4 1.7 1.8 1.6 1.6 1.3 1.3 1.7 1.1 1.1
Qualifications: None of the above 0.0 0.1 0.4 0.3 -0.6 -0.3 -0.3 -0.2 -0.4 -0.3 -0.5 -0.3 -0.3 -0.3 -0.2 -0.1 -0.3 -0.4 -0.4 -0.3 -0.1 -0.1 -0.2 -0.3 -0.0 -0.4 -0.2 0.3
Financial difficulties in last 2 years 0.2 0.2 2.5 0.3 -0.0 -0.2 -0.2 -0.6 -0.2 -0.3 -0.3 -0.2 -0.9 -0.2 -0.4 -0.7 -0.3 -0.2 -0.1 -0.3 -0.2 -0.4 -0.2 -1.6 -0.1 -0.3 -0.0 -0.2
Mouth/teeth dental problems 1.1 1.7 3.4 1.3 -1.1 -1.3 -1.2 -1.1 -1.3 -1.3 -1.3 -1.3 -1.0 -1.3 -1.3 -1.1 -1.4 -1.4 -1.3 -1.1 -1.2 -1.2 -1.3 -1.6 -1.3 -1.1 -1.3 -1.8
Heart attack 0.1 0.1 0.4 0.2 0.2 -0.2 -0.2 -0.3 -0.3 -0.3 -0.1 -0.2 -0.7 -0.3 -0.3 -0.4 0.2 -0.3 -0.5 -0.1 -0.2 0.2 -0.2 0.1 -0.3 -0.2 -0.1 0.3
Allergy 0.6 1.3 2.2 1.3 -0.7 -1.0 -1.1 -0.6 -1.2 -1.1 -1.3 -1.2 -1.5 -1.1 -1.0 -0.7 -1.1 -1.1 -1.0 -1.4 -1.4 -1.2 -1.4 -0.1 -1.5 -1.5 -1.4 -0.4
Pain all over the body in last month 0.1 0.1 0.7 -0.3 -0.4 -0.1 0.0 -0.4 0.1 0.1 -0.3 0.1 0.4 0.3 -0.1 -0.2 0.1 -0.0 0.3 0.3 -0.1 0.2 0.2 -0.8 0.2 0.3 0.2 0.1
Diabetes (self-reported) 1.6 2.5 4.5 1.1 -1.9 -1.8 -1.8 -1.7 -1.8 -1.3 -0.9 -1.6 -1.5 -1.2 -1.7 -1.4 -1.9 -2.1 -1.7 -1.2 -2.1 -1.5 -1.6 -1.2 -1.6 -1.1 -1.6 -1.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.0 -1.2 1.2 0.9 1.0 1.1 1.0 1.0 1.3 0.8 1.1 0.9 1.0 1.2 1.4 1.1 1.3 1.2 1.1 0.9 1.0 1.3 0.8 1.2 0.6 1.3
Medication: Ramipril 0.6 0.8 1.5 0.9 -1.0 -1.0 -1.0 -0.8 -1.0 -0.8 -0.8 -0.9 -1.2 -0.8 -0.9 -0.7 -1.1 -1.0 -0.8 -0.9 -1.0 -0.4 -0.9 -0.7 -1.0 -0.8 -0.9 -0.3
Medication: Simvastatin 3.5 5.1 6.4 2.1 -2.2 -2.3 -2.4 -2.1 -2.5 -2.3 -2.0 -2.5 -2.5 -2.4 -2.2 -2.1 -2.5 -2.3 -2.1 -2.2 -2.5 -2.0 -2.4 -1.9 -2.4 -2.3 -2.5 -1.4
Fluid intelligence score 0.1 0.3 0.7 -0.5 0.7 0.4 0.5 0.6 0.4 0.4 0.2 0.6 0.9 0.4 0.5 0.6 0.2 0.3 0.1 0.5 0.7 0.4 0.6 0.2 0.5 0.5 0.7 0.8
Illnesses of siblings 1.7 2.4 4.4 -1.4 1.5 1.7 1.7 1.2 1.7 1.5 0.8 1.6 2.1 1.6 1.5 1.2 1.9 1.8 1.7 1.5 1.5 1.6 1.5 1.8 1.7 1.4 1.5 1.0
Neuroticism score 0.3 0.6 2.2 -0.9 0.8 0.6 0.7 0.4 0.8 0.8 0.9 0.7 0.6 1.0 0.5 0.4 1.1 0.4 0.6 1.0 0.7 0.7 0.9 -0.5 0.6 1.1 0.7 1.5
Weight 0.2 1.0 4.7 0.8 -0.1 -0.7 -0.9 -0.5 -0.9 -0.9 -1.4 -1.1 -1.1 -0.9 -0.6 -0.6 -1.2 -0.7 -0.8 -0.8 -1.2 -0.4 -1.2 -1.0 -1.2 -0.7 -1.4 -2.2
Impedance of arm (right) 0.1 0.4 0.8 0.6 -0.8 -0.9 -0.7 -0.8 -0.7 -0.6 -0.6 -0.6 -0.5 -0.6 -0.9 -0.6 -0.3 -0.9 -0.5 -0.6 -0.6 -0.7 -0.6 -0.3 -0.3 -0.7 -0.5 -0.0
Arm fat percentage (right) 0.5 1.8 8.1 1.1 -0.4 -1.0 -1.2 -0.8 -1.3 -1.2 -1.6 -1.3 -1.7 -1.3 -0.9 -0.9 -1.4 -1.1 -1.1 -1.1 -1.5 -0.9 -1.5 -1.6 -1.4 -1.0 -1.6 -2.9
Trunk fat-free mass 0.0 0.3 0.8 -0.4 0.7 0.7 0.5 0.6 0.6 0.5 0.1 0.4 0.5 0.4 0.6 0.4 0.2 0.7 0.5 0.4 0.5 0.9 0.4 0.3 0.2 0.5 0.3 -0.4
Hip circumference 0.8 3.4 8.2 1.7 -1.1 -1.5 -1.8 -1.5 -1.8 -1.9 -2.4 -1.8 -2.0 -1.9 -1.6 -1.7 -2.1 -1.5 -1.7 -1.8 -1.9 -1.3 -2.0 -2.1 -2.0 -1.7 -1.9 -2.9
Time employed in main current job 1.7 2.0 3.1 1.1 -1.7 -1.6 -1.6 -1.8 -1.4 -1.2 -0.7 -1.5 -1.3 -1.1 -1.6 -1.6 -1.3 -1.6 -1.4 -1.3 -1.6 -1.2 -1.3 -1.8 -1.5 -1.1 -1.5 -0.4
Alcohol intake versus 10 years previously 0.8 1.2 2.4 0.9 -1.4 -1.3 -1.1 -1.3 -1.2 -1.0 -1.1 -1.1 -1.5 -0.9 -1.2 -1.1 -1.1 -1.4 -1.2 -0.9 -1.3 -0.9 -1.0 -0.2 -1.1 -0.8 -1.1 -0.1
Father’s age at death 0.9 1.2 1.7 -0.9 0.9 1.0 1.1 1.2 1.0 1.1 0.8 1.1 1.3 1.0 1.1 1.3 1.1 1.1 1.2 0.9 1.3 1.1 1.2 1.2 1.3 0.9 1.3 1.1
Worrier / anxious feelings 1.0 1.8 6.4 -1.5 1.1 0.8 1.1 0.8 1.3 1.4 2.0 1.1 1.6 1.5 0.9 1.1 2.0 0.8 1.0 1.5 1.2 0.9 1.4 0.7 1.2 1.6 0.9 2.5
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 1.7 -1.0 1.3 0.9 1.0 0.9 0.9 0.8 0.8 0.8 1.3 0.8 1.0 1.1 1.2 1.0 1.3 0.9 1.1 0.9 1.0 0.4 1.0 0.9 0.8 1.1
Falls in the last year 0.0 0.1 0.6 0.4 -0.2 -0.1 -0.1 -0.1 0.0 -0.2 -0.2 -0.1 0.2 -0.2 -0.0 -0.1 0.3 -0.0 -0.2 -0.4 0.3 -0.3 0.1 -0.0 0.1 -0.4 -0.0 0.8
Hair/balding pattern: Pattern 3 1.2 1.8 4.0 -1.4 0.6 1.5 1.3 1.0 1.4 1.5 1.7 1.4 1.1 1.4 1.2 0.9 1.0 1.3 2.0 1.4 1.0 1.4 1.2 1.5 1.5 1.4 1.3 0.7
Number of live births 0.2 0.3 1.6 -0.7 0.5 0.8 0.6 0.4 0.6 0.6 1.2 0.7 0.3 0.5 0.6 0.3 -0.0 0.7 0.7 0.7 0.3 0.5 0.4 0.3 0.4 0.6 0.7 0.2
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 3.7 1.3 -1.2 -1.3 -1.4 -1.5 -1.5 -1.5 -1.9 -1.4 -1.4 -1.5 -1.5 -1.6 -1.5 -1.4 -1.5 -1.2 -1.6 -1.5 -1.5 -1.0 -1.6 -1.1 -1.5 -1.5
Pulse rate 0.1 0.2 1.5 -0.5 -0.2 0.2 0.2 0.3 0.2 0.2 -0.2 0.3 0.8 0.3 0.3 0.5 0.3 0.2 0.2 0.5 0.4 0.1 0.5 -0.3 0.3 0.5 0.4 1.2
Happiness 1.8 2.1 3.8 -1.4 1.9 1.4 1.4 1.7 1.5 1.4 1.1 1.4 1.7 1.4 1.6 1.8 1.5 1.5 1.1 1.4 1.8 1.6 1.6 0.1 1.5 1.4 1.3 0.9
Noisy workplace 0.2 0.2 0.8 -0.5 0.0 0.1 0.3 -0.1 0.3 0.3 0.9 0.4 0.6 0.4 0.1 0.0 0.8 0.1 -0.1 0.5 0.4 0.0 0.5 0.4 0.5 0.5 0.5 0.8
Qualifications: A levels/AS levels or equivalent 2.1 4.6 13.8 -1.9 2.3 2.1 2.1 2.8 2.0 2.0 1.3 2.0 1.9 1.8 2.4 2.8 1.6 2.2 2.0 2.0 2.1 2.4 1.9 3.7 1.7 2.0 1.6 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 3.0 0.3 -0.1 -0.5 -0.3 0.1 -0.4 -0.2 0.3 -0.6 -0.2 -0.2 -0.1 0.4 -0.8 -0.4 -0.3 -0.3 -0.3 -0.2 -0.2 -1.7 -0.5 -0.2 -0.8 -0.3
Mouth/teeth dental problems: Dentures 0.1 0.1 1.8 -0.4 -0.1 0.1 0.1 0.3 0.0 0.2 0.2 0.0 -0.1 0.2 0.3 0.4 0.5 0.2 0.3 0.3 -0.2 0.2 0.0 1.4 0.1 0.2 -0.1 0.4
Asthma 0.8 1.7 4.0 -0.9 2.0 1.6 1.3 1.7 1.4 1.1 1.2 1.0 0.4 1.0 1.5 1.5 1.0 1.8 1.6 1.1 1.2 1.5 0.9 1.8 0.9 0.9 0.6 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.8 -0.5 1.3 1.0 1.0 1.0 0.9 0.7 0.8 0.8 1.2 0.6 1.0 0.9 1.0 1.1 0.7 0.6 1.1 0.4 0.8 -0.4 0.8 0.5 0.8 0.3
Medication: Cholesterol lowering 1.8 2.9 4.5 1.5 -2.0 -1.6 -1.7 -2.0 -1.7 -1.6 -1.3 -1.6 -1.9 -1.6 -1.9 -2.1 -1.9 -1.7 -1.5 -1.6 -2.0 -1.2 -1.8 -1.7 -1.6 -1.7 -1.5 -1.2
Depression (self-reported) 1.1 1.3 2.7 0.9 -1.5 -1.2 -1.1 -1.7 -1.0 -1.0 -1.0 -1.0 -1.0 -0.8 -1.3 -1.5 -1.2 -1.2 -1.3 -1.1 -1.1 -1.2 -0.9 -1.4 -1.1 -1.0 -0.9 -0.4
Medication: Lansoprazole 0.1 0.1 0.5 -0.3 -0.0 0.3 0.3 0.4 0.2 0.3 0.3 0.3 0.6 0.2 0.4 0.6 0.2 0.4 0.3 0.2 0.5 0.1 0.5 0.3 0.5 0.2 0.5 0.7
Prospective memory result 0.6 0.7 2.4 0.7 -0.9 -0.9 -0.8 -0.9 -0.7 -0.7 0.1 -0.9 -1.0 -0.7 -0.8 -0.8 -0.4 -0.8 -0.9 -0.8 -0.8 -1.0 -0.7 0.3 -0.8 -0.7 -1.0 -1.6
Lung cancer (father) 0.2 0.2 1.0 0.4 -0.5 -0.6 -0.3 -0.6 -0.4 -0.4 0.2 -0.6 -0.3 -0.4 -0.5 -0.6 -0.2 -0.5 -0.4 -0.4 -0.5 -0.4 -0.4 -0.4 -0.6 -0.3 -0.7 -1.0
Illnesses of mother 4.3 5.4 7.5 -1.9 2.1 2.6 2.6 2.3 2.4 2.2 2.2 2.6 2.0 2.2 2.4 2.0 2.7 2.7 2.6 2.1 2.5 2.5 2.3 2.1 2.6 1.8 2.6 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 3.9 1.4 -1.6 -1.5 -1.6 -1.9 -1.6 -1.6 -2.0 -1.6 -1.2 -1.5 -1.7 -1.8 -1.6 -1.6 -1.5 -1.4 -1.8 -1.9 -1.6 -1.4 -1.6 -1.3 -1.6 -1.3
Pulse wave Arterial Stiffness index 0.1 0.1 1.0 0.1 0.3 -0.1 -0.1 0.2 -0.1 -0.1 -0.1 -0.3 0.2 -0.2 -0.0 0.1 -0.0 0.0 0.1 -0.1 -0.1 0.1 -0.2 1.0 -0.4 -0.2 -0.4 0.4
Impedance of arm (left) 0.2 1.1 1.7 1.0 -1.2 -1.3 -1.1 -1.2 -1.1 -1.0 -1.0 -1.0 -1.1 -1.0 -1.3 -1.0 -0.8 -1.3 -0.8 -1.1 -1.1 -1.1 -1.0 -0.6 -0.7 -1.1 -0.8 -0.1
Arm fat mass (right) 0.5 2.0 8.4 1.1 -0.4 -1.0 -1.3 -0.8 -1.3 -1.3 -1.7 -1.4 -1.7 -1.4 -1.0 -1.0 -1.5 -1.1 -1.2 -1.2 -1.6 -0.9 -1.6 -1.5 -1.6 -1.1 -1.7 -2.9
Trunk predicted mass 0.1 0.3 1.0 -0.4 0.8 0.8 0.6 0.7 0.7 0.6 0.2 0.5 0.6 0.5 0.7 0.5 0.2 0.8 0.6 0.4 0.5 1.0 0.5 0.3 0.3 0.5 0.4 -0.3
Standing height 0.0 0.0 0.2 0.1 -0.1 -0.2 -0.1 -0.1 -0.0 -0.0 -0.4 -0.2 0.1 -0.0 -0.2 -0.1 -0.3 -0.2 0.2 -0.1 -0.2 0.4 -0.1 0.2 -0.1 -0.1 -0.3 0.2
Length of working week for main job 0.2 0.2 1.4 -0.1 -1.2 -0.3 -0.3 -0.9 -0.3 -0.1 0.1 -0.0 -0.3 0.0 -0.5 -0.8 -0.7 -0.4 -0.3 0.1 -0.5 -0.2 -0.1 -0.6 0.1 0.2 0.2 -0.3
Exposure to tobacco smoke at home 0.2 0.2 0.8 0.3 -0.1 -0.4 -0.4 -0.3 -0.4 -0.2 -0.5 -0.6 -0.8 -0.2 -0.4 -0.2 -0.5 -0.4 -0.0 -0.3 -0.8 -0.3 -0.6 -0.5 -0.6 -0.3 -0.9 -0.5
Breastfed as a baby 0.1 0.1 0.7 0.1 0.8 0.4 0.3 0.4 0.3 0.2 -0.2 0.2 0.6 0.1 0.3 0.3 0.1 0.3 0.1 -0.0 0.3 0.5 0.1 -0.1 0.2 -0.1 0.1 -0.1
Tense / ‘highly strung’ 0.2 0.3 1.0 0.3 -1.0 -0.7 -0.7 -0.6 -0.3 -0.1 -0.2 -0.5 -0.5 -0.1 -0.7 -0.4 -0.2 -0.8 -0.8 -0.4 -0.4 -0.8 -0.3 -0.5 -0.4 -0.3 -0.6 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.4 0.4 -1.0 -0.9 -0.8 -0.8 -0.5 -0.5 0.2 -0.6 -0.4 -0.4 -0.8 -0.6 -0.5 -0.9 -0.9 -0.5 -0.3 -1.1 -0.3 -1.2 -0.5 -0.3 -0.5 0.9
Hair/balding pattern: Pattern 4 0.9 2.1 3.3 1.5 -1.7 -1.4 -1.6 -1.5 -1.3 -1.4 -1.6 -1.5 -1.6 -1.4 -1.4 -1.5 -1.5 -1.4 -1.8 -1.6 -1.3 -1.5 -1.4 -0.4 -1.5 -1.5 -1.4 -1.0
Birth weight of first child 0.4 0.6 1.9 0.3 -1.2 -0.8 -0.7 -1.2 -0.7 -0.5 -0.1 -0.5 -0.9 -0.4 -0.9 -1.2 -1.0 -1.0 -0.7 -0.3 -1.0 -0.6 -0.6 -1.4 -0.5 -0.3 -0.3 -1.1
Peak expiratory flow (PEF) 0.7 1.7 3.7 1.2 -1.2 -1.1 -1.3 -1.0 -1.3 -1.3 -1.5 -1.2 -1.8 -1.3 -1.1 -1.1 -1.6 -1.2 -1.4 -1.1 -1.3 -1.2 -1.4 -0.1 -1.4 -1.0 -1.3 -1.9
Pulse wave reflection index 0.1 0.1 0.5 -0.2 0.7 0.2 0.2 0.3 0.2 0.2 0.6 0.1 0.3 0.1 0.2 0.2 0.4 0.3 0.5 0.2 0.1 0.1 0.1 0.5 -0.0 0.2 -0.1 -0.2
Ever highly irritable/argumentative for 2 days 0.2 0.2 1.5 -0.2 0.6 0.2 0.2 0.7 0.2 0.3 -0.0 0.0 -0.5 0.2 0.4 0.7 -0.0 0.3 0.1 0.3 -0.1 0.4 -0.1 1.2 -0.2 0.2 -0.3 -0.9
Loud music exposure frequency 0.4 0.5 2.6 0.7 -0.0 -0.5 -0.7 -0.5 -0.5 -0.5 -0.9 -0.7 -0.6 -0.5 -0.6 -0.7 -0.3 -0.6 -0.4 -0.7 -0.7 -0.7 -0.6 -1.6 -0.6 -0.6 -0.8 -0.8
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 3.6 -1.5 1.7 1.5 1.5 1.8 1.6 1.6 1.6 1.4 1.6 1.6 1.7 1.9 1.3 1.4 1.5 1.5 1.4 1.2 1.5 1.8 1.3 1.5 1.1 1.6
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.6 -0.4 0.3 0.5 0.4 0.5 0.6 0.5 0.7 0.5 0.5 0.5 0.5 0.5 0.6 0.6 0.6 0.3 0.6 0.4 0.6 0.2 0.4 0.3 0.5 0.4
Blood clot in the leg (DVT) 0.0 0.0 0.3 0.2 -0.5 0.1 -0.1 -0.0 -0.0 -0.3 -0.3 0.1 0.2 -0.3 0.1 -0.2 -0.0 0.1 -0.2 -0.1 0.3 0.1 0.0 -0.3 0.2 -0.0 0.2 -0.1
Medication: Paracetamol 0.5 0.8 1.5 -0.9 0.9 0.7 1.0 0.6 0.8 0.9 1.2 0.8 1.2 1.1 0.8 0.8 1.1 0.8 0.8 0.9 0.9 0.7 1.1 -0.2 1.0 0.8 0.8 0.9
Headache pain in last month 0.1 0.2 0.7 0.3 -0.9 -0.6 -0.4 -0.8 -0.3 -0.1 -0.3 -0.4 0.4 0.1 -0.5 -0.5 -0.7 -0.7 -0.5 -0.4 -0.2 -0.5 0.1 -0.8 -0.2 -0.2 -0.2 -0.4
Medication for cholesterol, blood pressure or diabetes 2.9 4.7 6.5 -1.9 2.2 2.2 2.3 2.5 2.1 2.1 1.5 2.2 2.3 2.0 2.4 2.6 2.4 2.2 2.1 2.0 2.5 1.7 2.3 2.4 2.3 2.0 2.2 1.6
Glaucoma (self-reported) 0.2 0.3 0.7 -0.6 0.6 0.4 0.5 0.4 0.5 0.5 0.4 0.6 0.4 0.6 0.5 0.5 0.5 0.3 0.2 0.6 0.5 0.2 0.6 -0.1 0.8 0.5 0.7 0.8
Gout (self-reported) 0.8 1.1 1.8 1.0 -0.9 -1.1 -1.1 -0.9 -1.1 -1.0 -0.4 -1.1 -1.4 -1.0 -1.0 -0.9 -1.1 -1.2 -1.3 -1.0 -1.2 -1.0 -1.1 -0.6 -1.1 -1.0 -1.2 -0.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.6 -1.6 0.8 1.1 0.9 0.7 1.1 1.2 1.0 1.1 0.9 1.2 0.9 0.7 0.6 0.9 1.3 1.4 0.5 0.8 0.9 1.0 0.9 1.5 0.9 0.6
Medication: Amlodipine 1.9 2.6 4.2 1.2 -1.9 -1.6 -1.7 -1.6 -1.6 -1.6 -1.2 -1.8 -2.0 -1.7 -1.6 -1.6 -1.7 -1.5 -1.7 -1.3 -1.8 -1.3 -1.8 -1.6 -1.9 -1.3 -2.1 -0.7
Medication: Ventolin 100micrograms inhaler 1.2 1.6 2.9 -1.5 1.1 1.3 1.2 1.5 1.2 1.1 1.7 1.2 0.6 1.0 1.3 1.4 0.9 1.4 1.3 1.4 1.3 1.4 1.1 1.6 1.0 1.4 0.9 0.6
Birth weight 0.1 0.2 1.7 -0.4 1.3 0.1 0.2 0.5 0.3 0.5 0.2 0.1 0.4 0.5 0.3 0.6 0.5 -0.0 -0.1 0.3 0.1 -0.0 0.2 -0.4 0.1 0.3 -0.1 -0.3
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.0 0.2 -0.8 -0.7 -0.5 -0.3 -0.4 -0.2 0.1 -0.7 0.2 -0.2 -0.5 -0.2 -0.4 -0.7 -0.3 -0.3 -0.4 -1.0 -0.3 -0.8 -0.7 -0.3 -0.9 0.1
High blood pressure (siblings) 0.9 1.3 3.4 0.8 -0.9 -1.3 -1.3 -1.1 -1.2 -1.1 -0.2 -1.2 -1.4 -1.0 -1.2 -1.0 -1.2 -1.4 -1.0 -1.0 -1.2 -1.3 -1.1 -1.8 -1.2 -0.9 -1.3 -0.4
Forced vital capacity (FVC), Best measure 0.3 1.2 2.3 0.9 -1.3 -1.1 -1.1 -1.3 -1.1 -1.1 -1.5 -1.1 -0.8 -1.1 -1.1 -1.2 -1.0 -1.1 -1.1 -1.0 -1.2 -1.4 -1.1 -0.7 -1.0 -0.9 -1.1 -1.0
Body fat percentage 1.1 4.5 11.2 1.9 -1.2 -1.9 -2.1 -1.5 -2.2 -2.1 -2.3 -2.2 -2.6 -2.2 -1.8 -1.6 -2.3 -1.9 -2.0 -1.9 -2.4 -1.7 -2.4 -1.9 -2.3 -1.8 -2.5 -3.4
Leg fat percentage (right) 1.5 5.5 9.2 2.2 -1.7 -2.1 -2.4 -1.8 -2.4 -2.3 -2.6 -2.5 -2.7 -2.4 -2.0 -1.9 -2.6 -2.1 -2.2 -2.3 -2.6 -2.2 -2.6 -2.2 -2.6 -2.2 -2.8 -3.0
Arm fat-free mass (right) 0.1 0.3 2.3 0.5 -0.1 -0.2 -0.4 -0.1 -0.3 -0.5 -0.8 -0.5 -0.7 -0.6 -0.2 -0.3 -0.9 -0.2 -0.4 -0.5 -0.6 -0.0 -0.7 -0.4 -0.8 -0.4 -0.7 -1.5
Exposure to tobacco smoke outside home 1.0 1.3 3.7 -1.3 0.4 0.9 1.0 1.0 1.2 1.2 1.0 1.1 1.4 1.3 1.1 1.2 1.0 1.0 1.0 1.3 1.3 0.5 1.4 0.3 1.2 1.4 1.0 1.9
Comparative body size at age 10 0.3 0.8 2.5 -0.9 1.6 1.1 0.9 1.1 0.9 0.9 0.9 0.7 0.4 0.8 1.1 1.0 0.9 1.1 1.0 0.9 0.6 1.1 0.6 0.8 0.7 0.9 0.4 -0.1
Number of full brothers 1.3 1.6 2.5 -1.2 1.2 1.4 1.4 1.2 1.3 1.2 1.2 1.2 1.2 1.2 1.3 1.2 1.6 1.3 1.5 1.4 1.2 1.4 1.2 1.1 1.3 1.2 1.1 0.5
Worry too long after embarrassment 0.5 0.8 1.6 0.7 -0.7 -0.8 -0.8 -1.1 -0.8 -0.8 -1.0 -0.7 -1.2 -0.8 -1.0 -1.3 -0.7 -0.8 -1.2 -0.6 -0.8 -0.7 -0.8 -1.2 -1.0 -0.6 -0.5 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 3.5 1.3 -1.9 -1.6 -1.7 -1.9 -1.4 -1.4 -0.9 -1.3 -1.8 -1.2 -1.7 -1.7 -1.2 -1.8 -1.6 -1.4 -1.4 -1.7 -1.3 -1.3 -1.3 -1.3 -1.0 -0.2
Wheeze or whistling in the chest in last year 2.2 3.8 6.8 -1.9 2.6 2.1 2.0 2.3 2.1 2.0 1.6 1.9 1.6 1.8 2.2 2.3 2.1 2.3 2.0 1.9 2.1 2.3 1.9 1.2 1.8 1.9 1.5 0.4
Number of children fathered 0.2 0.3 1.1 -0.9 -0.1 0.2 0.4 -0.0 0.3 0.6 1.0 0.5 -0.0 0.8 0.3 0.2 0.2 0.2 0.5 0.7 0.2 0.2 0.6 -0.0 0.6 0.7 0.7 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 3.7 4.3 7.3 -1.8 1.7 2.4 2.3 1.9 2.1 1.8 2.1 2.4 1.8 1.7 2.0 1.6 2.5 2.5 2.0 1.9 2.3 2.1 2.0 2.7 2.1 1.7 2.5 1.2
Age at first live birth 0.3 0.6 1.1 -0.8 1.1 0.6 0.7 0.9 0.7 0.8 0.4 0.7 0.7 0.7 0.7 1.0 1.1 0.6 0.8 0.7 0.9 0.9 0.8 0.2 0.7 0.7 0.7 0.1
Pulse wave peak to peak time 0.1 0.1 0.9 0.1 -0.4 -0.1 -0.1 -0.3 -0.1 -0.1 -0.1 0.0 -0.4 -0.0 -0.2 -0.3 -0.2 -0.2 -0.3 -0.1 -0.1 -0.3 -0.0 -1.0 0.2 -0.0 0.2 -0.5
Health satisfaction 0.2 0.3 0.8 -0.5 0.8 0.7 0.6 0.4 0.5 0.4 0.9 0.5 0.8 0.4 0.6 0.4 0.5 0.7 0.2 0.5 0.6 0.7 0.5 0.5 0.5 0.4 0.5 -0.1
Shortness of breath walking on level ground 2.0 2.4 4.0 1.2 -1.7 -2.0 -1.7 -1.7 -1.7 -1.5 -1.2 -1.8 -1.0 -1.4 -1.6 -1.3 -1.2 -1.9 -1.8 -1.3 -1.5 -1.7 -1.2 -1.8 -1.5 -1.2 -1.7 -0.9
Qualifications: College or University degree 0.0 0.1 0.3 -0.0 0.4 -0.2 -0.1 0.2 -0.0 -0.1 -0.5 -0.1 0.1 -0.1 0.0 0.3 0.3 -0.1 -0.5 0.0 0.1 -0.2 0.0 0.4 -0.3 0.0 -0.2 0.2
Eye problems/disorders: None of the above 0.1 0.1 0.5 0.3 -0.3 -0.3 -0.3 -0.4 -0.2 -0.1 -0.5 -0.3 -0.3 -0.2 -0.4 -0.4 -0.7 -0.2 0.0 -0.3 -0.3 -0.3 -0.3 -0.7 -0.4 -0.2 -0.4 -0.3
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.6 1.5 -0.7 -1.0 -1.1 -0.9 -1.1 -1.2 -1.3 -1.2 -1.2 -1.3 -1.0 -1.0 -0.9 -0.8 -1.0 -1.5 -1.0 -0.8 -1.2 -0.5 -1.2 -1.6 -1.2 -0.2
Emphysema/chronic bronchitis 0.1 0.1 0.9 0.1 -0.4 0.2 0.1 0.4 0.1 -0.1 0.1 0.1 0.0 -0.2 0.2 0.4 0.2 0.3 -0.0 -0.1 0.4 0.2 0.2 0.9 0.2 -0.1 0.2 -0.3
Medication for pain relief, constipation, heartburn 0.2 0.3 3.2 -0.6 -0.1 0.6 0.4 0.4 0.5 0.5 0.5 0.6 0.0 0.5 0.4 0.3 0.5 0.5 0.7 0.5 0.3 0.4 0.3 1.8 0.6 0.5 0.6 -0.2
Neck or shoulder pain in last month 0.7 1.0 2.5 -1.2 1.4 0.9 0.9 0.8 1.1 1.0 1.0 0.9 1.2 1.0 1.0 0.9 0.7 1.0 0.9 1.2 0.9 0.7 1.0 -0.2 0.9 1.2 0.6 1.6
Medication: Blood pressure 3.0 5.3 7.0 2.2 -2.1 -2.4 -2.5 -2.5 -2.2 -2.2 -1.7 -2.4 -2.4 -2.1 -2.5 -2.5 -2.4 -2.4 -2.3 -2.3 -2.5 -1.9 -2.3 -2.6 -2.5 -2.2 -2.4 -1.7
Angina (self-reported) 0.9 1.1 1.9 1.0 -1.0 -1.0 -1.0 -1.2 -1.1 -1.2 -0.7 -1.1 -1.2 -1.3 -1.1 -1.4 -0.6 -1.0 -1.0 -1.1 -1.1 -0.9 -1.1 -0.9 -1.2 -1.2 -1.0 -0.8
Migraine (self-reported) 1.2 1.5 2.9 1.4 -1.4 -1.2 -1.2 -1.2 -1.3 -1.3 -1.2 -1.3 -1.7 -1.4 -1.3 -1.3 -1.2 -1.1 -0.9 -1.4 -1.3 -1.2 -1.3 -0.3 -1.3 -1.4 -1.2 -0.4
Medication: Ibuprofen 0.4 0.4 1.2 -0.3 1.1 0.8 0.8 0.9 0.7 0.5 0.5 0.7 0.7 0.4 0.8 0.7 0.6 0.9 0.5 0.4 1.0 0.3 0.7 -0.3 0.7 0.3 0.7 -0.1
Medication: Allopurinol 0.2 0.2 0.8 -0.4 0.7 0.4 0.4 0.5 0.3 0.5 0.6 0.4 0.2 0.4 0.5 0.5 0.2 0.4 0.1 0.5 0.2 0.5 0.3 -0.1 0.3 0.5 0.4 0.9
Medication: Omeprazole 0.3 0.3 1.0 0.3 0.1 -0.7 -0.5 -0.8 -0.5 -0.5 -0.5 -0.6 -0.4 -0.4 -0.7 -0.7 -0.6 -0.7 -1.0 -0.3 -0.7 -0.3 -0.6 -0.8 -0.7 -0.3 -0.6 0.0
Medication: Seretide 50 evohaler 0.3 0.3 1.2 -0.6 0.4 0.3 0.4 0.9 0.3 0.4 0.9 -0.0 0.0 0.4 0.6 1.1 0.0 0.3 0.6 0.6 0.1 0.1 0.2 1.1 -0.2 0.6 -0.6 -0.6
Mean time to correctly identify matches 1.2 2.3 4.6 -1.3 2.1 1.4 1.5 1.4 1.5 1.6 1.5 1.4 1.5 1.5 1.5 1.5 1.5 1.3 1.6 1.4 1.4 1.8 1.4 1.2 1.5 1.4 1.2 1.9
Heart disease (mother) 0.1 0.1 0.8 -0.1 0.2 -0.2 -0.3 0.5 -0.3 -0.2 0.1 -0.5 0.1 -0.4 0.1 0.6 -0.4 -0.2 -0.3 0.1 -0.2 0.0 -0.3 0.4 -0.7 0.1 -0.9 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.1 6.1 7.6 -2.5 2.2 2.8 2.7 2.6 2.6 2.6 2.6 2.7 2.1 2.7 2.6 2.4 2.4 2.6 2.6 2.5 2.5 2.1 2.5 1.7 2.5 2.5 2.5 1.7
Whole body fat mass 0.8 3.2 10.1 1.5 -0.9 -1.5 -1.8 -1.2 -1.7 -1.7 -2.0 -1.9 -2.2 -1.8 -1.4 -1.4 -2.0 -1.5 -1.6 -1.6 -2.0 -1.3 -2.0 -1.7 -2.0 -1.5 -2.1 -3.2
Leg fat mass (right) 0.7 2.7 8.0 1.5 -0.8 -1.3 -1.6 -1.0 -1.6 -1.6 -2.0 -1.7 -2.0 -1.7 -1.2 -1.1 -1.8 -1.3 -1.5 -1.5 -1.8 -1.1 -1.8 -1.7 -1.8 -1.4 -2.0 -2.8
Arm predicted mass (right) 0.0 0.1 1.5 0.3 0.1 0.0 -0.2 0.0 -0.1 -0.2 -0.5 -0.3 -0.4 -0.3 0.0 -0.1 -0.7 0.0 -0.2 -0.2 -0.3 0.2 -0.4 -0.3 -0.5 -0.1 -0.5 -1.2
Pulse rate, automated reading 0.0 0.1 1.2 -0.4 -0.5 -0.2 -0.2 -0.4 -0.2 -0.1 -0.2 -0.1 0.1 -0.0 -0.2 -0.4 0.2 -0.2 0.0 0.4 -0.4 0.2 -0.1 -0.2 -0.0 0.3 -0.2 1.1
Alcohol intake frequency. 0.3 0.8 1.6 0.7 -0.6 -0.9 -0.9 -1.0 -0.9 -0.7 -0.6 -1.0 -1.3 -0.6 -0.9 -0.9 -1.0 -1.0 -0.6 -0.7 -1.3 -0.8 -1.0 -0.6 -1.0 -0.7 -1.2 -0.7
Comparative height size at age 10 0.2 1.1 3.5 -1.2 1.7 0.9 1.0 1.4 1.0 1.1 0.9 0.6 0.8 0.9 1.1 1.5 0.9 1.0 1.2 1.2 0.6 1.1 0.7 1.9 0.5 1.2 0.1 0.3
Number of full sisters 0.5 0.6 3.1 0.3 -0.7 -0.9 -0.7 -0.9 -0.7 -0.6 -0.6 -0.6 -0.4 -0.5 -0.9 -0.9 -0.8 -1.0 -0.8 -0.4 -0.7 -0.6 -0.5 -1.8 -0.5 -0.3 -0.5 1.0
Suffer from ‘nerves’ 0.7 1.1 2.1 -1.4 0.9 0.8 0.9 0.8 1.1 1.2 1.4 1.0 1.3 1.3 0.9 1.0 1.0 0.7 0.7 1.2 1.1 0.7 1.2 0.7 1.0 1.4 0.8 1.2
Overall health rating 0.1 0.1 1.3 -0.1 0.5 -0.2 -0.1 -0.4 -0.2 -0.3 -0.4 -0.2 0.6 -0.3 -0.2 -0.4 0.2 -0.1 -0.4 0.1 0.0 0.4 -0.0 -1.1 -0.1 0.1 -0.1 0.1
Chest pain or discomfort 0.1 0.1 0.7 0.0 0.8 -0.1 0.1 0.6 -0.1 -0.2 0.0 -0.3 0.1 -0.3 0.2 0.7 0.3 0.1 -0.2 0.0 0.2 0.5 -0.1 -0.1 -0.2 -0.1 -0.7 0.2
Had major operations 0.2 0.3 2.2 -0.5 0.2 0.4 0.4 0.5 0.5 0.4 0.9 0.3 0.0 0.4 0.4 0.5 0.4 0.5 0.6 0.5 0.3 0.5 0.3 1.5 0.3 0.4 0.2 -0.2
Age at last live birth 1.3 1.8 3.1 -1.5 1.6 1.3 1.4 1.7 1.4 1.4 1.3 1.3 1.2 1.3 1.5 1.8 1.2 1.3 1.3 1.5 1.4 1.5 1.3 0.6 1.1 1.4 1.1 0.7
Family relationship satisfaction 0.7 0.9 2.1 -1.4 0.7 0.5 0.6 0.8 0.8 1.1 1.1 0.7 1.2 1.2 0.7 1.1 0.8 0.3 0.8 1.3 0.8 1.0 1.1 0.7 0.9 1.5 0.6 0.7
Leg pain on walking 0.7 0.9 1.8 -1.1 1.4 1.1 1.0 0.7 0.9 1.1 1.2 1.0 0.8 1.1 1.1 0.8 0.8 0.9 1.0 1.1 0.7 0.7 1.0 0.3 1.0 1.2 0.9 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.8 -0.7 0.4 0.6 0.6 0.5 0.5 0.6 0.6 0.5 0.1 0.6 0.6 0.5 0.3 0.5 0.7 0.7 0.2 0.1 0.4 0.2 0.5 0.9 0.3 0.0
Commuting to job workplace: Car/motor vehicle 1.3 1.5 3.3 -1.5 1.0 1.0 1.0 1.0 1.1 1.3 1.4 1.1 1.8 1.4 1.1 1.2 1.2 1.0 1.0 1.4 1.0 1.0 1.3 1.3 1.2 1.5 1.1 0.7
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 4.6 -1.0 0.7 1.0 1.0 0.5 1.0 1.0 0.5 1.0 0.8 1.0 0.7 0.4 1.2 0.9 1.1 1.1 0.5 1.0 0.8 2.1 0.9 1.1 0.9 0.6
Medication: Aspirin 2.8 3.7 5.6 2.0 -1.2 -2.1 -2.1 -1.1 -2.1 -2.2 -1.8 -2.3 -2.2 -2.3 -1.7 -1.2 -2.0 -1.9 -1.9 -2.1 -1.8 -1.4 -2.1 -1.5 -2.2 -2.1 -2.4 -1.5
Supplements: Vitamin C 0.0 0.1 0.3 0.1 -0.5 0.0 0.1 0.1 0.1 -0.1 0.2 0.2 0.0 -0.1 0.1 0.1 -0.2 0.2 0.1 -0.0 0.5 0.2 0.3 0.5 0.2 0.0 0.5 0.2
Knee pain experienced in last month 2.9 4.5 6.2 -1.8 2.4 2.4 2.3 2.4 2.2 2.1 2.0 2.1 2.2 2.0 2.5 2.3 1.7 2.5 2.0 1.9 2.2 2.5 2.1 0.8 2.1 1.9 1.9 2.3
Hypertension (Self-reported) 1.4 4.0 7.7 1.9 -1.5 -2.1 -2.1 -1.8 -1.9 -1.8 -1.8 -2.4 -2.3 -1.9 -2.0 -1.8 -1.9 -1.9 -1.9 -2.0 -2.4 -1.5 -2.2 -1.5 -2.5 -2.0 -2.8 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.1 0.2 -0.3 -0.1 0.1 0.0 -0.1 0.1 0.2 0.1 0.2 0.4 0.2 0.1 -0.0 -0.4 0.2 0.2 0.2 0.1 0.0 0.2 0.4 0.1 0.3 0.3 0.5
Illnesses of father: Heart disease 0.9 1.2 2.9 1.0 -0.9 -1.0 -1.1 -0.1 -1.2 -1.1 -0.9 -1.3 -1.1 -1.4 -0.7 0.0 -1.3 -0.9 -1.1 -1.0 -1.0 -1.1 -1.2 0.1 -1.3 -1.0 -1.7 -1.6
Illnesses of siblings: Diabetes 0.9 1.1 2.3 0.8 -0.8 -1.1 -1.0 -1.0 -1.1 -0.9 -0.5 -1.1 -1.5 -0.9 -1.0 -0.9 -1.1 -1.2 -1.1 -0.8 -1.3 -0.9 -1.1 -1.3 -1.1 -0.8 -1.2 -0.6
Smoking status: Previous 0.3 0.4 1.5 0.2 -0.9 -0.9 -0.7 -0.7 -0.6 -0.4 -0.1 -0.8 -0.6 -0.3 -0.6 -0.4 -0.3 -0.8 -0.5 -0.4 -0.8 -1.2 -0.5 -0.2 -0.7 -0.4 -0.9 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.5 -1.4 1.2 0.9 1.2 0.9 1.1 1.1 1.2 1.2 1.5 1.1 1.0 1.0 1.6 1.2 1.2 1.4 1.3 1.1 1.3 0.7 1.2 1.4 1.3 0.9
Whole body fat-free mass 0.0 0.1 0.8 -0.2 0.7 0.5 0.3 0.4 0.4 0.3 -0.1 0.2 0.2 0.2 0.4 0.3 -0.0 0.5 0.3 0.2 0.2 0.7 0.1 0.0 0.0 0.3 0.0 -0.9
Leg fat-free mass (right) 0.0 0.2 1.0 -0.3 0.9 0.6 0.5 0.6 0.4 0.3 -0.1 0.3 0.2 0.3 0.6 0.5 0.2 0.6 0.3 0.4 0.3 0.9 0.2 0.2 0.1 0.4 0.1 -1.0
Arm fat percentage (left) 0.7 2.7 9.7 1.4 -0.7 -1.3 -1.6 -1.1 -1.6 -1.6 -1.8 -1.6 -2.1 -1.7 -1.3 -1.2 -1.8 -1.3 -1.5 -1.4 -1.8 -1.2 -1.9 -1.7 -1.8 -1.3 -1.9 -3.1
Average weekly red wine intake 0.8 1.1 2.8 -0.7 1.2 1.2 1.1 1.7 1.1 1.0 0.6 1.1 1.0 0.9 1.4 1.6 0.8 1.3 1.0 0.7 1.4 0.7 1.1 1.0 1.0 0.6 1.1 0.1
Handedness (chirality/laterality): Left-handed 3.3 4.0 8.5 -2.0 1.6 1.8 1.9 1.6 1.9 2.0 2.0 2.1 2.3 2.0 1.8 1.7 2.2 1.8 1.8 2.0 2.2 1.4 2.3 0.9 2.2 2.1 2.2 2.9
Mood swings 0.1 0.1 2.6 0.2 0.1 -0.1 -0.0 -0.4 -0.1 -0.1 -0.1 -0.1 -0.4 0.0 -0.3 -0.4 -0.2 -0.2 -0.1 -0.1 -0.3 -0.0 -0.1 -1.6 -0.2 -0.1 -0.0 -0.0
Loneliness, isolation 0.3 0.4 2.7 -1.0 0.3 0.2 0.3 -0.2 0.5 0.6 0.8 0.5 0.7 0.7 0.1 -0.1 0.7 -0.0 0.2 0.8 0.1 0.2 0.5 0.2 0.4 1.0 0.4 1.6
Long-standing illness, disability or infirmity 0.1 0.1 0.5 -0.3 0.5 -0.2 0.0 -0.4 0.1 0.2 0.5 -0.0 -0.0 0.3 -0.2 -0.3 -0.1 -0.2 0.0 0.3 -0.1 0.6 0.2 -0.7 0.1 0.3 0.0 -0.1
Ever had bowel cancer screening 0.1 0.1 0.7 -0.2 -0.0 -0.3 -0.1 -0.1 0.0 0.3 0.2 -0.2 0.9 0.4 -0.1 0.3 -0.0 -0.4 -0.2 0.1 -0.1 -0.3 0.2 0.1 0.0 0.2 -0.3 0.5
Diabetes diagnosed by doctor 2.3 3.7 6.3 1.4 -2.3 -2.2 -2.1 -2.4 -2.1 -1.6 -1.5 -1.8 -1.8 -1.4 -2.2 -2.1 -1.9 -2.5 -2.1 -1.5 -2.4 -1.9 -1.8 -2.1 -1.7 -1.4 -1.5 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.7 0.1 -0.2 0.1 -0.1 0.1 0.0 0.1 -0.1 -0.1 0.1 0.1 0.0 0.1 -0.3 0.0 0.2 -0.1 -0.1 -0.2 -0.1 0.0 -0.0 -0.0 -0.2 -0.8
Friendships satisfaction 0.1 0.1 0.4 -0.3 0.6 -0.0 0.1 0.2 0.1 0.2 -0.1 0.1 0.6 0.2 0.1 0.3 0.1 -0.1 0.1 0.3 0.3 0.6 0.3 -0.4 0.2 0.4 0.2 -0.4
Qualifications: nursing, teaching 0.6 1.0 2.9 -1.3 0.4 0.9 0.9 0.6 0.9 0.9 1.3 1.3 0.7 0.9 0.8 0.6 0.7 0.9 1.0 1.2 1.1 0.8 1.2 0.5 1.2 1.2 1.7 1.0
Commuting to job workplace: Walk 1.1 1.1 1.9 -0.8 1.2 1.1 1.2 1.4 1.0 0.9 1.1 1.1 0.6 0.8 1.2 1.4 1.3 1.1 0.9 0.9 1.4 1.1 1.1 0.6 1.1 0.9 1.2 0.7
Eye problems/disorders: Cataract 0.5 0.6 1.4 1.1 0.1 -0.4 -0.7 0.2 -0.7 -0.8 -0.6 -0.9 -1.0 -0.9 -0.3 -0.0 -0.3 -0.4 -0.6 -1.0 -0.6 -0.2 -1.0 0.2 -0.9 -1.1 -1.1 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.7 -0.6 0.6 0.7 0.7 0.5 0.7 0.8 0.5 0.7 0.5 0.8 0.6 0.4 0.3 0.7 0.7 0.5 0.6 0.6 0.7 0.0 0.6 0.5 0.7 1.3
Medication for cholesterol 0.3 0.4 0.9 -0.5 0.7 0.4 0.6 0.5 0.6 0.6 0.5 0.6 1.0 0.6 0.5 0.6 0.5 0.5 0.4 0.6 0.7 0.8 0.7 0.9 0.6 0.5 0.6 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.6 -0.4 1.0 0.5 0.6 0.6 0.5 0.4 0.1 0.6 0.6 0.5 0.6 0.7 1.2 0.5 0.3 0.4 0.7 0.6 0.7 0.5 0.5 0.3 0.8 1.3
Back pain experienced in last month 0.1 0.2 1.2 -0.4 -0.5 -0.2 -0.1 -0.9 0.0 0.1 0.3 0.1 0.3 0.1 -0.4 -0.9 0.1 -0.2 -0.3 0.3 -0.3 -0.6 0.0 -1.1 -0.1 0.4 0.1 0.6
Mineral and other dietary supplements 5.2 7.0 11.3 2.1 -2.8 -2.8 -2.7 -3.0 -2.7 -2.4 -1.5 -2.7 -3.0 -2.3 -2.8 -2.8 -2.7 -2.8 -2.3 -2.3 -3.1 -3.4 -2.6 -3.3 -2.8 -2.1 -2.8 -1.5
Breast cancer (self-reported) 0.4 0.5 1.8 0.7 0.5 -0.5 -0.5 -0.3 -0.7 -0.8 -0.6 -0.7 -0.7 -0.9 -0.5 -0.5 -0.6 -0.4 -0.6 -0.7 -0.6 -0.2 -0.8 -0.6 -0.9 -0.9 -0.7 -1.3
Asthma (self-reported) 0.7 1.4 4.1 -0.7 2.0 1.4 1.2 1.7 1.3 1.0 1.0 0.9 0.2 0.8 1.4 1.4 0.8 1.7 1.5 0.9 1.1 1.4 0.7 1.9 0.8 0.7 0.5 -0.5
Osteoporosis (self-reported) 0.7 0.8 1.6 1.0 -0.1 -1.2 -0.9 -0.7 -1.0 -1.1 -0.9 -1.2 -0.5 -1.2 -0.9 -0.6 -0.5 -0.9 -1.3 -1.0 -0.6 -0.8 -0.9 -0.3 -1.1 -1.1 -1.2 -0.5
Osteoarthritis (self-reported) 0.3 0.4 1.3 -0.6 1.1 0.6 0.6 0.3 0.8 0.7 0.7 0.5 0.7 0.7 0.5 0.3 0.7 0.7 0.7 0.6 0.4 0.7 0.6 0.3 0.3 0.5 0.4 0.5
Medication: Aspirin 4.1 5.4 7.6 2.4 -1.7 -2.5 -2.5 -1.6 -2.6 -2.6 -2.1 -2.7 -2.6 -2.8 -2.1 -1.5 -2.3 -2.4 -2.5 -2.5 -2.2 -1.7 -2.5 -1.6 -2.6 -2.5 -2.7 -1.9
Medication: Gliclazide 0.2 0.2 0.9 -0.2 0.9 0.5 0.5 0.7 0.3 0.4 -0.1 0.5 0.2 0.3 0.5 0.6 0.1 0.5 0.5 0.3 0.3 0.4 0.3 0.6 0.3 0.2 0.5 0.9
Illnesses of father: None of the above (group 1) 0.5 0.7 1.2 -0.7 1.0 1.0 0.9 0.4 1.0 0.7 1.0 0.9 0.7 0.8 0.7 0.2 1.0 1.0 0.7 0.7 0.8 1.1 0.7 1.0 0.7 0.6 1.0 -0.2
Smoking status: Current 0.1 0.2 1.2 0.4 -0.5 -0.3 -0.2 -0.7 -0.4 -0.4 -0.1 -0.1 -0.1 -0.3 -0.5 -0.8 -0.4 -0.5 -0.5 -0.3 -0.1 0.1 -0.1 -1.1 0.0 -0.3 0.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.9 5.6 1.9 -1.6 -2.0 -2.0 -1.8 -2.1 -2.0 -2.2 -2.1 -2.0 -2.0 -1.8 -1.7 -2.2 -1.9 -1.9 -1.8 -2.4 -1.8 -2.2 -1.6 -2.1 -1.7 -2.3 -1.8
Whole body water mass 0.0 0.2 0.8 -0.3 0.8 0.6 0.5 0.5 0.5 0.4 -0.0 0.3 0.3 0.3 0.6 0.4 0.1 0.6 0.4 0.4 0.3 0.9 0.3 0.2 0.1 0.5 0.1 -0.8
Leg predicted mass (right) 0.0 0.3 0.9 -0.3 1.0 0.6 0.5 0.7 0.5 0.4 -0.0 0.3 0.2 0.3 0.6 0.6 0.2 0.6 0.4 0.4 0.3 0.9 0.3 0.3 0.2 0.5 0.1 -1.0
Arm fat mass (left) 0.6 2.3 8.6 1.3 -0.5 -1.2 -1.4 -0.9 -1.4 -1.4 -1.8 -1.6 -1.9 -1.5 -1.1 -1.0 -1.7 -1.2 -1.3 -1.3 -1.7 -0.9 -1.7 -1.4 -1.7 -1.2 -1.8 -2.9
Number of self-reported non-cancer illnesses 0.3 0.5 2.0 0.3 -0.2 -0.7 -0.7 -1.1 -0.5 -0.5 -0.5 -0.7 -0.5 -0.4 -0.9 -1.1 -0.7 -0.6 -0.4 -0.4 -0.9 0.0 -0.6 -1.4 -0.8 -0.3 -0.9 0.1
Average weekly champagne plus white wine intake 0.9 1.2 2.6 -1.1 0.7 1.0 1.0 0.9 1.1 1.1 1.0 1.2 1.3 1.1 1.0 0.9 1.6 1.0 0.9 1.0 1.3 0.5 1.3 0.4 1.2 1.0 1.4 1.4
Miserableness 0.0 0.0 0.5 0.1 -0.2 -0.1 0.1 -0.3 -0.1 -0.1 0.2 -0.1 0.1 0.0 -0.1 -0.2 0.5 -0.2 -0.2 -0.0 0.1 -0.3 0.2 -0.7 -0.0 -0.0 0.0 0.2
Guilty feelings 0.5 0.8 1.5 -1.0 1.0 0.8 0.8 0.7 0.9 1.0 1.0 0.9 1.2 1.0 0.8 0.7 1.2 0.6 1.0 1.1 0.7 0.7 0.8 0.2 1.0 1.1 0.7 0.8
Wears glasses or contact lenses 0.5 0.5 1.3 0.9 -0.8 -0.8 -0.8 -0.5 -0.8 -0.9 -0.7 -0.7 -0.7 -1.0 -0.8 -0.7 -0.9 -0.7 -0.7 -0.8 -0.4 -0.3 -0.6 -0.1 -0.6 -0.8 -0.4 -1.1
Ever taken oral contraceptive pill 0.1 0.1 0.4 0.2 -0.6 -0.3 -0.3 -0.1 -0.2 -0.3 -0.1 -0.3 0.2 -0.4 -0.1 0.0 0.1 -0.1 -0.6 -0.2 -0.1 -0.4 -0.2 0.5 -0.4 -0.1 -0.4 0.0
Hearing aid user 3.6 4.0 6.0 -2.1 2.1 2.1 2.2 1.9 2.0 1.9 2.0 2.1 1.5 2.0 2.0 1.9 1.7 2.1 2.5 2.0 2.0 2.0 1.9 1.7 2.1 2.0 2.0 2.1
Mother’s age at death 0.6 0.7 3.0 0.6 -1.0 -1.0 -0.8 -1.3 -0.8 -0.9 -1.1 -0.7 -0.3 -0.7 -1.0 -1.2 -0.5 -0.8 -0.6 -0.7 -0.6 -1.0 -0.6 -1.7 -0.7 -0.7 -0.4 -0.4
Financial situation satisfaction 0.6 0.8 2.2 -0.9 0.9 0.7 0.8 0.7 0.8 0.8 0.9 0.8 1.0 0.8 0.7 0.8 1.1 0.7 0.5 0.9 0.9 1.2 0.9 1.5 0.8 0.8 0.8 0.8
Tinnitus: Yes, now most or all of the time 0.1 0.1 1.2 0.4 0.3 0.1 0.1 0.5 -0.0 -0.2 -0.4 -0.1 -0.2 -0.2 0.2 0.3 -0.3 0.2 0.0 -0.2 0.0 0.2 -0.2 -0.3 -0.1 -0.4 -0.1 -1.1
Commuting to job workplace: Public transport 0.1 0.1 0.6 0.3 -0.4 -0.3 -0.3 0.2 -0.3 -0.1 -0.3 -0.2 -0.5 -0.2 -0.1 0.4 -0.8 -0.3 -0.3 -0.3 -0.2 0.1 -0.2 -0.3 -0.2 -0.2 -0.3 0.0
Eye problems/disorders: Glaucoma 0.2 0.2 1.9 -0.4 -0.1 0.3 0.3 0.1 0.5 0.5 0.4 0.5 0.0 0.6 0.2 0.2 0.3 0.1 0.1 0.4 0.4 -0.2 0.6 0.5 0.7 0.3 0.7 1.4
Medication: Blood pressure 1.6 3.0 4.9 1.9 -1.5 -1.5 -1.7 -1.3 -1.8 -1.9 -1.4 -2.0 -1.9 -2.1 -1.4 -1.4 -1.5 -1.4 -1.5 -1.9 -1.9 -1.7 -2.0 -0.9 -2.0 -2.0 -2.2 -1.8
Pain type(s) experienced in last month: Hip pain 3.3 4.1 6.0 -2.1 2.3 2.5 2.2 1.8 2.4 2.2 1.9 2.3 2.0 2.2 2.1 1.6 1.6 2.4 2.0 2.1 2.0 1.9 2.0 0.8 1.9 2.1 2.2 0.8
Supplements: Fish oil (including cod liver oil) 1.5 2.0 8.5 -1.0 1.2 1.3 1.3 1.3 1.4 1.3 0.7 1.4 1.3 1.2 1.3 1.2 1.5 1.3 1.0 1.1 1.6 2.0 1.4 2.9 1.5 0.9 1.6 0.5
High cholesterol (Self-reported) 3.5 6.1 10.0 2.4 -2.9 -2.4 -2.4 -2.8 -2.5 -2.5 -2.4 -2.2 -2.9 -2.4 -2.6 -2.9 -3.1 -2.5 -2.1 -2.4 -2.5 -2.2 -2.4 -3.2 -2.2 -2.4 -1.9 -1.3
Medication: Bendroflumethiazide 0.7 1.1 2.0 1.2 -0.7 -0.9 -1.0 -0.9 -1.1 -1.2 -0.8 -1.1 -1.4 -1.2 -1.0 -1.0 -0.6 -0.8 -0.9 -1.2 -1.0 -0.8 -1.1 -0.9 -1.2 -1.3 -1.1 -1.3
Medication: Paracetamol 0.2 0.3 0.9 -0.5 0.6 0.4 0.7 0.4 0.5 0.6 0.8 0.5 0.9 0.7 0.6 0.6 0.4 0.5 0.3 0.6 0.7 0.6 0.8 0.1 0.6 0.5 0.7 0.4
Medication: Lisinopril 2.9 3.7 6.1 2.1 -1.5 -1.7 -2.0 -1.5 -1.9 -1.8 -1.7 -2.2 -2.0 -1.9 -1.7 -1.5 -2.1 -1.8 -1.7 -2.1 -2.4 -2.1 -2.3 -0.4 -2.2 -2.2 -2.5 -2.0
Medication: Atorvastatin 3.0 3.8 6.0 1.9 -2.4 -2.1 -2.0 -2.4 -2.0 -2.0 -2.1 -1.9 -1.7 -1.9 -2.2 -2.4 -1.4 -2.1 -1.8 -1.9 -1.9 -2.1 -1.8 -1.8 -1.6 -1.9 -1.6 -0.8
Illnesses of father: High blood pressure 0.4 0.5 1.2 0.9 -0.3 -0.5 -0.5 -0.1 -0.8 -0.9 -1.0 -0.7 -0.3 -1.1 -0.4 -0.2 -0.2 -0.4 -0.6 -0.9 -0.4 -1.1 -0.7 -0.7 -0.6 -1.0 -0.7 0.3
Alcohol drinker status: Never 0.1 0.1 0.5 -0.3 0.5 0.3 0.2 0.6 0.3 0.3 0.6 0.1 0.4 0.3 0.4 0.6 -0.0 0.2 0.4 0.3 0.3 -0.0 0.3 0.7 0.1 0.3 -0.0 0.4
Ever smoked 0.0 0.1 0.7 0.1 0.0 -0.3 -0.2 -0.4 -0.2 -0.1 -0.0 -0.2 0.1 -0.0 -0.3 -0.3 -0.3 -0.3 -0.2 -0.2 -0.2 -0.5 -0.1 -0.9 -0.1 -0.1 -0.0 -0.2
Basal metabolic rate 0.0 0.1 1.6 0.1 0.5 0.2 0.0 0.2 0.1 -0.0 -0.5 -0.1 -0.2 -0.1 0.2 0.0 -0.3 0.2 0.0 -0.0 -0.1 0.4 -0.2 -0.2 -0.3 0.1 -0.3 -1.3
Leg fat percentage (left) 1.4 5.2 9.7 2.1 -1.5 -2.0 -2.3 -1.6 -2.3 -2.2 -2.5 -2.4 -2.7 -2.4 -1.9 -1.7 -2.6 -2.0 -2.1 -2.2 -2.5 -2.1 -2.6 -2.0 -2.5 -2.1 -2.7 -3.1
Arm fat-free mass (left) 0.0 0.1 1.1 0.1 0.4 0.2 0.0 0.3 0.1 -0.0 -0.4 -0.1 -0.2 -0.1 0.2 0.1 -0.4 0.2 0.0 -0.0 -0.1 0.4 -0.2 -0.0 -0.4 0.1 -0.3 -1.0
Number of operations (self-reported) 0.2 0.2 0.8 -0.5 -0.4 0.4 0.4 -0.6 0.4 0.4 0.8 0.6 0.2 0.5 0.0 -0.7 0.3 0.4 0.6 0.5 0.1 0.2 0.4 -0.1 0.6 0.5 0.9 0.3
Average weekly beer plus cider intake 0.3 0.4 1.4 -0.6 0.3 0.6 0.6 0.8 0.6 0.5 0.9 0.6 0.6 0.4 0.7 0.8 0.4 0.7 0.2 0.7 0.7 0.9 0.6 1.2 0.5 0.6 0.5 0.4
Irritability 1.8 3.1 8.3 1.8 -2.2 -1.8 -1.7 -1.8 -1.6 -1.7 -1.7 -1.5 -1.7 -1.5 -1.8 -1.8 -2.0 -2.0 -2.2 -1.7 -1.4 -1.7 -1.4 -2.9 -1.5 -1.6 -1.1 -1.4
Risk taking 2.2 3.2 6.0 -2.0 1.0 1.5 1.7 1.0 1.9 1.7 2.2 2.0 1.6 1.9 1.3 0.9 2.5 1.6 1.5 1.9 2.1 1.3 2.1 1.3 2.1 1.9 2.3 2.2
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.4 -0.4 -0.0 0.0 0.0 -0.1 0.3 0.4 0.6 0.1 -0.4 0.4 -0.0 -0.1 -0.3 -0.1 0.1 0.3 -0.0 -0.1 0.2 -0.2 0.2 0.4 -0.0 0.4
Fractured/broken bones in last 5 years 3.1 4.0 8.9 -1.8 2.5 1.8 1.9 2.4 1.8 1.8 2.0 1.7 2.4 1.7 2.2 2.6 1.7 1.9 1.7 1.9 2.2 1.9 2.0 3.0 1.9 1.9 1.6 0.8
Age started oral contraceptive pill 0.2 0.3 1.1 -0.3 1.0 0.4 0.4 0.6 0.3 0.2 0.1 0.3 0.3 0.1 0.5 0.6 1.0 0.4 0.0 0.3 0.4 0.5 0.2 1.0 0.2 0.2 0.1 1.0
Diastolic blood pressure, automated reading 0.2 0.7 1.7 0.7 -0.9 -0.6 -0.8 -0.8 -0.7 -0.8 -0.9 -0.7 -0.8 -0.8 -0.8 -1.0 -1.0 -0.6 -0.8 -0.7 -0.9 -0.6 -0.9 -1.3 -1.0 -0.7 -0.8 -0.9
Ever depressed for a whole week 0.1 0.1 0.3 -0.2 0.1 0.2 0.2 0.5 0.3 0.3 0.5 0.3 0.3 0.2 0.3 0.5 -0.0 0.1 -0.2 0.2 0.5 0.1 0.4 -0.1 0.3 0.3 0.4 0.1
Unable to work because of sickness or disability 1.3 1.7 8.0 -1.5 0.7 0.9 1.1 0.6 1.2 1.2 1.1 1.3 1.6 1.4 0.9 0.8 1.0 1.0 1.2 1.4 1.4 1.1 1.5 -0.9 1.5 1.6 1.5 2.8
Commuting to job workplace: Cycle 0.3 0.3 1.1 1.0 -0.2 -0.4 -0.4 -0.6 -0.5 -0.7 -1.1 -0.4 -0.2 -0.7 -0.5 -0.7 -0.4 -0.3 -0.4 -0.8 -0.4 -0.4 -0.6 -0.8 -0.3 -0.8 -0.3 -0.2
Myopia 0.7 1.0 3.4 1.1 -0.6 -0.8 -0.9 -0.9 -1.0 -1.0 -1.2 -0.9 -0.8 -1.1 -0.9 -1.0 -1.1 -0.8 -0.6 -1.1 -1.1 -0.4 -1.1 -1.9 -0.9 -1.0 -0.9 -0.6
Vascular/heart problems diagnosed by doctor 1.8 5.0 9.2 -2.3 1.5 2.2 2.3 2.0 2.2 2.1 2.1 2.7 2.6 2.2 2.3 2.1 2.0 2.1 2.0 2.4 2.6 1.8 2.6 1.5 2.8 2.4 3.0 1.7
Cholesterol lowering medication 8.1 11.9 14.2 3.4 -3.3 -3.6 -3.6 -3.4 -3.7 -3.7 -3.8 -3.5 -3.5 -3.6 -3.5 -3.4 -3.4 -3.6 -3.5 -3.5 -3.5 -3.4 -3.5 -3.4 -3.4 -3.5 -3.3 -1.9
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.4 0.5 -0.5 -1.0 -0.9 -1.2 -0.8 -0.7 -0.7 -0.9 -0.8 -0.6 -1.0 -1.1 -0.9 -1.0 -1.2 -0.5 -1.2 -0.6 -0.9 -1.0 -1.1 -0.5 -1.0 -0.4
Pain experienced in last month 0.7 1.2 3.1 1.0 -1.1 -1.1 -1.1 -0.8 -1.2 -1.1 -0.9 -1.1 -1.5 -1.2 -1.0 -0.8 -0.6 -1.1 -0.9 -1.0 -1.3 -1.0 -1.3 0.0 -1.1 -1.1 -1.2 -1.8
Supplements: Calcium 0.8 0.9 2.7 -0.5 1.1 0.9 0.8 1.5 0.8 0.6 0.7 0.9 0.6 0.3 1.1 1.3 0.6 1.0 0.9 0.6 1.4 1.0 0.8 1.6 0.8 0.6 1.0 0.5
Basal cell carcinoma (self-reported) 0.4 0.5 1.9 0.8 0.4 -0.4 -0.6 0.2 -0.7 -0.6 -1.1 -0.7 -1.1 -0.8 -0.3 0.0 -0.7 -0.5 -0.5 -0.7 -0.7 -0.1 -0.8 0.7 -0.8 -0.7 -0.8 -1.4
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.3 0.0 0.3 -0.1 -0.1 -0.1 -0.2 -0.2 0.0 -0.1 -0.5 -0.2 -0.2 -0.2 0.3 -0.2 -0.3 0.0 -0.1 0.4 -0.2 0.5 -0.3 -0.0 -0.1 0.3
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.3 -0.0 -0.5 0.2 -0.0 -0.1 0.1 -0.2 -0.2 0.3 0.4 -0.2 0.1 -0.3 0.1 0.2 -0.1 0.0 0.4 0.2 0.2 -0.4 0.3 0.1 0.5 -0.0
Heart disease (siblings) 0.3 0.4 0.9 0.5 -0.9 -0.8 -0.8 -0.4 -0.8 -0.6 -0.1 -0.8 -0.8 -0.6 -0.6 -0.3 -0.8 -0.8 -0.6 -0.6 -0.8 -0.5 -0.7 -0.3 -0.9 -0.6 -0.9 0.1
Alcohol drinker status: Previous 0.0 0.0 0.2 -0.1 0.4 0.0 0.1 0.3 0.0 0.0 0.1 -0.1 0.1 -0.0 0.2 0.5 0.2 0.1 0.2 0.2 0.1 0.3 0.1 0.1 0.0 0.2 -0.3 -0.0
Pack years of smoking 0.0 0.0 0.3 0.1 0.5 -0.0 0.0 0.2 0.0 -0.1 0.3 -0.1 0.5 -0.2 0.1 0.2 0.2 0.1 -0.1 -0.1 0.1 0.1 -0.0 0.2 -0.1 -0.1 -0.2 -0.3
Impedance of whole body 0.4 2.3 3.6 1.4 -1.9 -1.8 -1.7 -1.6 -1.6 -1.5 -1.4 -1.5 -1.6 -1.5 -1.7 -1.5 -1.3 -1.8 -1.3 -1.5 -1.6 -1.7 -1.5 -0.9 -1.3 -1.6 -1.4 -0.4
Leg fat mass (left) 0.6 2.1 7.4 1.3 -0.6 -1.1 -1.4 -0.8 -1.4 -1.4 -1.8 -1.6 -1.8 -1.5 -1.0 -0.9 -1.7 -1.2 -1.3 -1.3 -1.6 -1.0 -1.6 -1.5 -1.7 -1.2 -1.9 -2.7
Arm predicted mass (left) 0.0 0.1 1.3 0.1 0.5 0.3 0.1 0.4 0.1 -0.0 -0.4 -0.1 -0.1 -0.1 0.3 0.2 -0.3 0.3 0.1 -0.0 -0.1 0.5 -0.2 -0.1 -0.3 0.1 -0.3 -1.1