TWAS hub - PANX2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1600	0.0640	0.0044	0.012	NA	0.030	NA	-0.001	7.0e-02	NA	8.4e-03	NA	3.9e-01
2	YFS	Blood	0.2205	0.0362	0.0000	0.067	0.121	0.123	0.124	0.110	5.3e-21	2.6e-37	3.7e-38	3e-38	5.5e-34
3	TCGA	Cervical Squamous Cell Carcinoma	0.1230	0.0650	0.0028	0.075	0.043	0.035	NA	0.072	1.5e-04	3.4e-03	7.6e-03	NA	2.1e-04
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0462	0.0249	0.0053	0.020	0.013	0.013	NA	0.017	2.3e-03	1.2e-02	1.0e-02	NA	4.8e-03
5	TCGA	Liver Hepatocellular Carcinoma	0.1170	0.0580	0.0015	0.054	0.098	0.070	NA	0.073	1.5e-03	2.4e-05	3.5e-04	NA	2.6e-04
6	TCGA	Lung Adenocarcinoma	0.0379	0.0241	0.0088	0.016	0.001	0.021	NA	0.004	5.4e-03	2.5e-01	1.5e-03	NA	1.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Commuting to job workplace: Walk	3.8	4.1	7.4	2.7	1.0	2.2	2.1	2.4	1.2
Unable to work because of sickness or disability	3.3	4.3	9.5	-1.1	0.8	3.1	2.3	0.7	3.0
Current tobacco smoking	3.1	5.1	10.5	1.7	-0.4	2.9	2.8	3.2	0.5
Emphysema/chronic bronchitis	2.8	3.1	7.2	-0.8	-2.7	-1.4	-1.5	0.5	-2.6
Smoking status: Current	2.5	4.0	8.8	1.3	-0.5	2.7	2.4	3.0	0.4
Commuting to job workplace: Public transport	2.4	2.9	5.1	1.9	-0.9	0.9	2.3	2.1	-1.6
Maternal smoking around birth	2.3	3.3	10.9	1.3	-1.1	1.9	3.3	1.5	0.1
Handedness (chirality/laterality): Left-handed	2.3	2.8	7.6	2.8	-1.0	0.9	1.3	2.1	-1.1
Blood Platelet Count	2.2	26.1	68.2	1.3	-1.4	5.7	8.3	7.1	-1.6
Qualifications: CSEs or equivalent	2.1	2.8	9.6	-1.1	1.4	0.0	-0.9	-1.8	3.1
Mouth/teeth dental problems: Loose teeth	2.1	2.5	4.3	0.6	-1.5	1.9	2.0	2.1	0.2
Heart disease (mother)	2.1	2.6	5.4	-2.3	1.3	-0.8	-1.4	-2.1	1.2
Loneliness, isolation	2.1	2.9	5.4	0.9	0.8	2.3	2.2	0.2	2.3
Medication: Gliclazide	2.1	2.4	5.8	-0.7	2.2	2.4	-0.7	0.5	1.5
Chest pain or discomfort	2.0	2.9	7.4	-1.2	2.5	1.2	-0.4	-0.9	2.7
Number of operations (self-reported)	2.0	3.0	8.0	0.8	-2.7	-1.3	-0.0	0.7	-2.8
Fractured/broken bones in last 5 years	2.0	2.5	4.5	1.7	-1.5	1.8	1.4	2.1	-0.7
Depressed Affect (Nagel 2018)	1.9	4.1	7.8	1.9	1.1	2.8	0.8	2.3	2.4
Smoking Status	1.9	4.7	9.4	2.5	0.4	3.1	1.8	2.8	1.0
Falls in the last year	1.9	2.5	4.8	1.9	0.6	2.2	1.4	2.0	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	5.4	1.4	-0.6	2.0	1.3	2.3	-0.7
Medication: Omeprazole	1.8	2.1	4.3	-2.0	1.0	-0.9	-0.9	-2.1	1.4
Qualifications: nursing, teaching	1.8	2.7	6.6	-1.0	2.6	-1.8	-0.8	-2.1	0.7
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	10.3	-0.3	-1.4	1.4	3.2	1.4	1.0
Exposure to tobacco smoke outside home	1.7	2.3	5.3	2.3	1.4	1.4	0.2	1.8	1.0
Exposure to tobacco smoke at home	1.6	1.8	5.8	2.4	-0.1	-1.3	-1.0	0.1	-1.5
Basal cell carcinoma (self-reported)	1.6	1.9	6.7	-1.1	-2.6	-0.9	-0.9	0.1	-1.4
Fasting Glucose	1.5	1.8	5.1	-0.9	1.2	0.8	-2.3	-0.8	1.5
Medication: Co-codamol	1.5	1.8	6.3	-0.7	-2.5	-1.0	1.1	0.1	-1.2
Lung cancer (father)	1.5	1.8	5.0	-1.5	-0.1	-1.7	-0.7	-2.2	0.5
Commuting to job workplace: Car/motor vehicle	1.5	1.8	2.9	-1.7	-0.3	-1.4	-1.6	-1.6	-0.7
Alzheimer’s Disease (in father)	1.4	1.6	4.8	0.3	-1.9	-0.6	0.1	0.8	-2.2
Verbal and Numeric Reasoning (VNR)	1.4	3.4	10.0	2.0	-0.5	-0.2	1.3	2.1	-3.2
Hand grip strength (left)	1.4	3.6	7.3	-1.0	-1.6	-1.9	-2.3	-1.2	-2.7
Ever had hysterectomy (womb removed)	1.4	1.5	4.9	1.1	-0.4	2.2	1.0	0.8	1.2
Had other major operations	1.4	1.7	5.1	0.3	-1.6	-0.9	-0.6	1.1	-2.3
Medication: Ibuprofen	1.4	1.6	3.5	1.4	-0.8	1.4	1.2	1.9	-0.7
Ever taken oral contraceptive pill	1.4	1.6	4.0	-0.5	-0.1	-2.0	-1.1	-2.0	-0.7
Ever smoked	1.4	2.5	4.4	1.9	-0.4	1.7	2.1	2.0	-0.4
Alzheimer’s Disease (in mother)	1.3	1.5	4.9	-2.2	0.1	-0.1	1.9	-0.2	-0.4
Neuroticism	1.3	3.1	5.7	2.4	1.2	2.2	-0.1	2.0	1.4
Pack years adult smoking proportion	1.3	2.0	4.0	2.0	0.4	1.2	1.8	1.6	0.6
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	6.6	-2.6	-1.5	-1.1	-1.1	-1.2	-1.8
Eye problems/disorders: None of the above	1.3	1.5	3.5	1.2	0.3	1.3	0.9	1.9	-1.2
Had major operations	1.3	1.5	5.1	-0.5	-2.3	-1.2	-0.1	-0.5	-1.4
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.4	1.0	-1.8	-1.6	-0.6	-0.6	-1.3
Fed-up feelings	1.2	2.1	5.9	1.8	-0.1	2.4	-0.3	1.7	0.6
Medication: Ramipril	1.2	1.5	4.1	2.0	-0.4	1.8	0.5	1.1	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.2	0.1	-0.3	2.0	1.5	1.1	0.9
Qualifications: College or University degree	1.2	3.6	7.5	-0.1	0.0	-2.7	-2.6	-0.8	-2.6
Mood swings	1.2	2.3	5.8	1.3	0.4	2.4	-0.8	2.1	0.9
Breast cancer (self-reported)	1.2	1.4	3.0	-0.6	-1.5	-1.7	-0.9	-0.4	-1.2
Medication: Lisinopril	1.2	1.5	2.7	0.7	-1.6	-1.2	-1.5	-0.1	-1.4
Intelligence (Savage-Jansen 2018)	1.1	3.4	11.0	2.1	0.3	-1.1	1.5	1.3	-3.3
Relative age of first facial hair	1.1	2.3	3.1	1.1	-1.7	1.8	1.6	1.3	1.6
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	5.2	1.0	-0.8	0.2	2.3	1.2	0.4
Medication: Metformin	1.1	1.5	4.7	-1.0	1.0	1.3	0.1	-0.7	2.2
Had menopause	1.1	1.3	4.6	0.8	-1.1	-0.5	0.4	1.1	-2.1
Impedance of arm (left)	1.1	5.2	16.8	1.2	4.1	0.6	-2.4	-1.1	2.4
Length of working week for main job	1.1	1.2	2.0	0.4	-1.4	-1.4	-1.2	-0.1	-1.3
Pulse wave reflection index	1.1	1.4	4.4	-0.6	1.7	-0.7	-2.1	-0.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.9	-0.8	0.2	-1.4	-1.7	-1.6	0.1
Average weekly red wine intake	1.1	1.7	3.3	-1.2	-0.9	-1.7	-1.8	-0.6	-1.0
Medication for cholesterol	1.1	1.7	5.3	1.1	0.5	0.6	1.4	1.0	2.3
Irritability	1.1	1.8	4.7	2.2	-0.7	0.2	-0.9	1.2	-1.8
Alzheimer’s Disease (including proxy)	1.0	1.4	3.6	-1.2	-0.8	-0.1	1.5	0.8	-1.9
Blood Red Count	1.0	9.7	21.3	-1.5	-4.6	-3.4	-3.4	-2.5	-2.1
Hypothyroidism (self reported)	1.0	2.2	8.4	-2.9	-0.4	-0.9	-0.9	-1.5	-1.0
Average weekly spirits intake	1.0	1.2	2.6	-1.5	-0.1	-1.0	-0.5	-1.6	1.1
Diabetes (mother)	1.0	1.2	2.6	-1.0	-1.6	-0.5	-1.2	-1.4	-0.4
Hand grip strength (right)	1.0	2.7	6.6	-0.7	-1.5	-1.4	-2.0	-1.2	-2.6
Townsend deprivation index at recruitment	1.0	1.3	2.7	1.5	-1.1	1.1	0.8	1.6	-0.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.0	0.6	-1.5	2.0	0.5	0.4	-0.0
Qualifications: None of the above	1.0	2.2	4.6	-0.1	-2.1	2.1	0.8	1.9	-0.1
Time employed in main current job	1.0	1.2	3.1	-1.7	0.2	-0.5	-1.8	-0.4	-0.7
Alcohol intake versus 10 years previously	1.0	1.6	4.2	-1.2	-2.0	-1.0	0.3	-1.6	-0.1
Medication: Lansoprazole	1.0	1.1	2.6	1.3	0.7	-0.2	0.7	1.1	-1.6
Prospective memory result	1.0	1.2	4.0	0.8	-0.6	0.5	2.0	0.7	1.3
Hair/balding pattern: Pattern 4	1.0	2.4	7.9	0.6	-0.5	-1.8	-1.6	-0.3	-2.8
Blood clot in the leg (DVT)	1.0	1.3	3.6	-0.6	1.4	1.2	0.6	-0.2	1.9
Mean time to correctly identify matches	1.0	1.8	4.0	-2.0	-1.9	-1.2	0.3	-1.5	0.1
Eye problems/disorders: Cataract	1.0	1.1	2.6	-1.1	-0.5	-0.2	-0.8	-1.4	1.6
Commuting to job workplace: Cycle	1.0	1.2	2.7	-1.6	1.2	-1.1	-0.4	-1.2	0.6
Ulcerative Colitis (UC)	0.9	1.6	3.4	1.6	0.6	1.5	-1.1	0.1	1.8
Prostate Cancer	0.9	1.3	5.2	-2.3	0.2	-0.4	0.5	-0.7	1.3
Ulcerative Colitis	0.9	1.3	3.1	0.8	1.1	1.5	-0.6	0.1	1.8
Stomach or abdominal pain in last month	0.9	1.2	2.4	-0.6	0.7	-0.8	-1.6	-1.3	1.2
Hearing difficulty/problems with background noise	0.9	1.4	3.4	-0.9	1.3	0.0	-1.1	-1.8	1.3
Impedance of arm (right)	0.9	4.3	14.2	1.5	3.8	0.5	-2.2	-0.8	1.9
Father’s age at death	0.9	1.2	1.8	1.2	-1.0	-1.3	-0.9	-0.0	-1.4
Birth weight	0.9	2.0	7.0	0.4	-2.6	0.2	1.1	1.6	-0.9
Medication: Blood pressure	0.9	1.8	4.8	-1.4	-0.4	-0.9	-1.3	-1.1	-2.2
Alcohol drinker status: Never	0.9	1.1	3.0	0.4	-0.5	1.0	1.3	1.7	-0.6
Average weekly beer plus cider intake	0.9	1.3	2.8	1.0	0.4	1.7	1.0	1.5	0.5
Pack years of smoking	0.9	1.3	3.1	1.8	0.6	1.0	1.2	1.3	0.5
Neuroticism (Nagel 2018)	0.8	1.8	3.0	1.1	1.0	1.7	0.4	1.7	1.6
Reaction Time	0.8	1.5	4.2	-2.1	-0.4	-1.1	-0.1	-1.5	1.0
Chronotype (morning person)	0.8	1.9	6.7	1.2	-2.6	-0.2	0.1	0.7	-1.6
Alcohol usually taken with meals	0.8	1.2	4.1	-0.2	0.0	-1.3	-1.1	0.3	-2.0
Diabetes (self-reported)	0.8	1.2	2.9	0.8	0.9	1.7	-0.3	-0.5	1.6
Qualifications: A levels/AS levels or equivalent	0.8	1.9	7.1	0.3	0.2	-1.7	-1.1	-0.0	-2.7
Loud music exposure frequency	0.8	0.9	2.5	-0.9	1.6	0.1	1.0	-0.1	0.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.4	-1.6	1.0	0.7	0.0	-0.6	1.4
Medication: Allopurinol	0.8	1.0	3.2	-0.5	0.5	1.8	0.4	0.4	1.4
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.5	1.4	0.8	1.6	0.0	0.3	0.8
Financial situation satisfaction	0.8	1.0	2.4	0.7	-1.1	1.5	0.4	1.4	-0.0
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.4	1.0	0.1	1.9	0.9	0.6	1.0
Risk taking	0.8	1.1	2.7	1.1	0.8	1.6	0.7	1.0	0.9
Myopia	0.8	1.1	2.1	-0.3	-0.4	1.4	1.4	1.4	0.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.1	-1.5	0.6	-0.7	-0.7	-1.4	0.7
Heart disease (siblings)	0.8	1.0	3.2	0.2	-0.8	1.8	0.4	1.3	0.3
Blood White Count	0.7	5.4	11.7	0.6	-3.4	-0.4	2.6	2.6	-2.6
Sensitivity / hurt feelings	0.7	1.2	3.4	0.1	-0.5	-0.7	-1.5	0.8	-1.8
Age when periods started (menarche)	0.7	1.8	4.4	-1.0	1.4	-1.7	-0.6	-2.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.0	0.7	0.0	-0.9	0.1	-0.2	-1.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	-0.2	1.2	-1.2	0.4	-1.3	0.4
Medication: Levothyroxine sodium	0.7	1.1	3.4	-1.8	-1.2	-0.4	-0.3	-0.5	-1.3
Past tobacco smoking	0.7	1.3	2.5	-1.2	-0.3	-1.4	-1.6	-1.2	-0.5
Mouth/teeth dental problems	0.7	1.1	2.3	0.7	-0.5	-1.1	-1.5	-0.6	-1.3
Illnesses of siblings	0.7	1.0	2.7	1.6	1.2	0.0	0.9	0.6	-0.8
Depression (self-reported)	0.7	0.8	2.5	0.1	-0.6	0.9	0.9	1.6	-0.7
Pulse wave peak to peak time	0.7	0.8	2.6	1.3	-0.6	0.2	1.6	0.3	-0.0
Leg pain on walking	0.7	0.9	1.2	-1.1	0.9	-0.2	1.1	-1.1	1.1
Diabetes diagnosed by doctor	0.7	1.2	2.9	0.3	1.0	1.7	0.1	-0.4	1.7
Illnesses of father: None of the above (group 1)	0.7	0.8	2.3	0.3	1.3	-0.1	0.3	-0.9	1.5
Hearing aid user	0.7	0.7	1.7	-0.5	-1.3	-0.6	-0.8	-1.1	0.6
Medication: Bendroflumethiazide	0.7	1.1	3.0	-1.5	-1.7	-0.4	-0.5	-0.4	-0.9
Age started oral contraceptive pill	0.7	0.9	1.9	1.0	1.3	1.4	0.4	0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.2	-0.4	1.0	1.2	0.8	0.2	1.5
Coronary Artery Disease (CAD)	0.6	0.7	1.8	0.0	0.0	1.2	0.8	0.2	1.4
HbA1C	0.6	0.7	1.6	0.1	0.7	1.1	-0.2	1.3	0.9
Lupus	0.6	1.0	3.5	0.5	-0.1	-0.5	-1.4	-0.1	-1.9
Heel T-Score	0.6	4.4	11.0	0.1	-1.8	-2.3	-3.3	-1.3	-2.2
Medication for hormone replacement therapy	0.6	0.6	2.2	-0.1	-1.5	0.2	0.3	-0.1	-1.1
Relative age voice broke	0.6	0.9	2.3	-0.6	-0.9	-0.8	-1.1	-1.5	-0.0
Serious illness, injury or assault to yourself	0.6	0.7	1.8	-0.4	-1.3	-1.1	-0.0	-0.6	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.8	-0.3	1.1	0.7	-1.2	-0.5	1.4
Heart attack	0.6	0.8	1.9	0.5	-1.4	0.4	0.0	1.0	-1.1
Fluid intelligence score	0.6	1.3	3.9	1.0	0.1	-0.5	1.3	1.1	-2.0
Neuroticism score	0.6	1.3	3.0	1.7	-0.0	1.4	-0.6	1.5	0.2
Pulse wave Arterial Stiffness index	0.6	0.7	2.5	-1.1	0.7	-0.0	-1.6	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.8	-0.3	1.0	-1.7	-1.1	-0.7	-0.5
Medication: Amlodipine	0.6	0.8	3.2	0.2	-0.9	-0.3	-0.7	-0.1	-1.8
Arm fat-free mass (right)	0.6	2.9	9.7	-0.4	-3.1	-0.3	1.5	1.2	-2.0
Worry too long after embarrassment	0.6	1.0	3.1	-0.3	0.7	1.4	0.5	0.3	1.8
Health satisfaction	0.6	0.8	1.7	-1.3	-0.9	-0.7	0.2	-0.1	-1.2
Medication: Blood pressure	0.6	1.0	3.3	0.1	-1.8	-0.2	-0.4	0.3	-1.5
Arm predicted mass (right)	0.6	3.3	10.5	-0.3	-3.2	-0.5	1.8	1.1	-2.1
Number of full sisters	0.6	0.7	2.3	-1.1	-0.3	-0.1	0.4	-0.8	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.5	-1.1	0.3	0.6	-0.0	-1.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.8	-1.9	0.9	-0.1	-0.1	-1.4	1.2
Number of self-reported non-cancer illnesses	0.6	1.0	2.5	-0.6	-0.7	-0.3	-1.6	-0.3	-1.6
Age at First Birth	0.5	0.7	2.2	1.5	-0.2	0.5	0.1	1.0	-0.7
Mean Putamen Volume	0.5	0.6	1.0	0.3	-0.8	-1.0	-0.9	-0.9	-0.4
HDL Cholesterol	0.5	0.9	1.9	-1.1	1.4	-0.5	0.1	-0.8	1.2
LDL Cholesterol	0.5	0.7	2.3	-0.9	0.4	-0.0	0.2	-1.0	1.5
Waist Hip Ratio (WHR)	0.5	2.4	7.3	2.7	0.1	0.9	1.8	1.3	1.2
Allergy or Eczema	0.5	1.2	3.8	-0.0	-0.2	-1.5	-0.8	-0.8	-1.9
Systolic blood pressure, automated reading	0.5	1.5	4.3	0.3	-1.9	0.1	-0.6	0.8	-2.1
Supplements: Zinc	0.5	0.5	1.6	0.2	-1.3	-0.6	0.8	-0.5	-0.3
Severe depression (siblings)	0.5	0.6	2.7	-1.6	0.2	-0.4	-0.5	-0.5	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.1	1.1	-0.1	-1.0	-1.2	-0.3	-1.8
Supplements: Glucosamine	0.5	0.6	1.2	-0.6	1.0	1.1	-0.6	-0.0	0.7
Financial difficulties in last 2 years	0.5	0.7	1.5	-0.6	-1.1	-1.2	0.1	-0.2	-1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.7	-1.3	0.5	0.5	-0.5	-0.8	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.1	-0.6	1.0	1.4	-0.3	0.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.3	0.4	1.2	-0.5	0.7	0.3	-0.9
Gout (self-reported)	0.5	0.6	1.6	-0.3	1.3	1.0	-0.6	-0.1	1.0
Number of full brothers	0.5	0.6	1.4	-1.1	0.1	0.1	-1.1	-1.2	-0.0
Shortness of breath walking on level ground	0.5	0.6	1.8	-0.1	-1.3	0.4	1.0	0.8	0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	3.3	-0.1	-0.6	-1.8	-0.3	-1.0	-0.6
Medication: Seretide 50 evohaler	0.5	0.6	3.1	1.8	0.1	0.2	0.4	0.1	0.5
Family relationship satisfaction	0.5	0.6	1.4	0.4	0.4	1.1	1.2	0.9	0.0
Medication: Aspirin	0.5	0.7	1.0	-0.5	0.7	1.0	-1.0	-0.5	1.0
Knee pain experienced in last month	0.5	0.8	2.9	-0.2	1.7	-0.4	-0.8	-0.7	0.8
Hypertension (Self-reported)	0.5	1.3	4.5	-1.0	-0.6	-0.5	-1.1	-0.7	-2.1
Long-standing illness, disability or infirmity	0.5	0.8	2.6	-0.8	0.1	0.6	1.6	0.2	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	0.6	-0.3	0.1	1.3	-0.4	1.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	-1.0	-1.1	0.0	-0.3	-0.6	0.9
Arm fat-free mass (left)	0.5	2.6	8.0	-0.1	-2.8	-0.4	1.7	1.1	-1.8
Impedance of whole body	0.5	2.6	9.2	0.7	3.0	0.5	-1.7	-1.0	1.3
Arm predicted mass (left)	0.5	2.7	9.8	-0.5	-3.1	-0.6	1.3	0.8	-1.9
Schizophrenia (2018)	0.4	0.9	3.4	-0.5	1.8	0.3	-0.4	-0.4	1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	-0.4	1.1	0.4	0.0	-0.7	0.8
Crohns Disease (2017)	0.4	0.8	1.9	0.2	-0.4	-1.2	-1.4	-0.1	-1.0
Neuroticism (2016)	0.4	0.6	2.3	-0.8	-0.4	-0.2	-1.5	-0.5	0.6
Number of treatments/medications taken	0.4	0.7	2.4	-1.6	0.6	0.5	-0.7	-0.7	0.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.9	0.6	1.4	0.2	-0.4	0.4	1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.1	-0.3	-0.7	1.1	-0.5	-1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.2	-1.1	-0.1	-0.6	-0.6	-0.7	0.5
Angina	0.4	0.5	1.3	-1.0	-0.6	0.1	1.1	0.4	-0.4
Diabetes (father)	0.4	0.5	1.8	1.4	0.1	0.3	0.1	-0.4	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.4	-0.4	0.4	1.1	0.6	0.4	1.2
High blood pressure	0.4	1.1	4.2	-0.8	-0.4	-0.4	-1.1	-0.7	-2.1
Medication: Atenolol	0.4	0.5	1.0	-0.9	-1.0	-0.7	-0.6	-0.6	-0.4
Waist circumference	0.4	1.5	7.4	0.5	-2.7	-0.4	0.6	0.4	-0.8
Nervous feelings	0.4	0.7	1.7	1.1	-0.4	-0.8	-1.3	0.3	-0.8
Allergy	0.4	0.9	2.1	0.8	-0.5	1.0	1.3	1.4	0.3
Trunk fat-free mass	0.4	2.4	7.7	-0.2	-2.8	-0.1	1.5	1.2	-1.8
Hip circumference	0.4	1.5	7.1	-0.1	-2.7	0.0	0.6	0.7	-1.1
Worrier / anxious feelings	0.4	0.7	1.8	0.7	0.8	1.0	-1.3	0.4	0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	2.4	1.0	0.7	0.5	1.6	0.6	0.1
Medication: Cholesterol lowering	0.4	0.6	1.4	-0.2	0.8	0.9	-0.7	-0.5	1.2
Illnesses of mother	0.4	0.5	1.5	1.2	-0.3	0.4	-0.8	0.7	0.6
Trunk predicted mass	0.4	2.3	7.5	-0.3	-2.7	-0.2	1.4	1.1	-1.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-0.6	1.0	0.7	0.6	0.5	-0.8
Headache pain in last month	0.4	0.7	2.0	-0.2	1.4	0.9	0.6	-0.0	1.0
High blood pressure (siblings)	0.4	0.6	1.9	-0.9	-0.8	-0.3	-1.4	-0.4	0.3
Comparative body size at age 10	0.4	1.1	2.1	1.2	0.3	1.4	-0.2	1.2	1.3
Angina (self-reported)	0.4	0.6	1.3	-1.0	-0.8	0.2	1.1	0.4	-0.6
Age at last live birth	0.4	0.6	2.0	0.7	-1.4	-0.5	0.3	0.5	-0.8
Supplements: Vitamin C	0.4	0.5	2.2	-1.5	0.2	0.1	0.7	-0.6	0.3
Illnesses of father: Heart disease	0.4	0.5	0.7	-0.8	-0.8	0.7	0.8	0.8	-0.1
Smoking status: Previous	0.4	0.6	1.0	1.0	0.6	1.0	0.6	0.8	0.4
Whole body fat-free mass	0.4	2.0	6.2	-0.0	-2.5	0.1	1.5	1.4	-1.4
Osteoporosis (self-reported)	0.4	0.5	1.8	0.6	-0.6	0.6	0.3	1.3	0.1
Osteoarthritis (self-reported)	0.4	0.5	2.1	0.5	0.2	0.7	0.2	1.4	0.6
Medication: Aspirin	0.4	0.5	1.1	-0.7	0.1	0.1	-1.0	-0.9	0.5
Whole body water mass	0.4	2.0	6.3	-0.1	-2.5	0.0	1.5	1.3	-1.3
Miserableness	0.4	0.6	2.0	0.1	0.8	0.8	-0.4	0.6	1.4
Mother’s age at death	0.4	0.5	2.3	0.7	1.5	0.2	0.0	0.4	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.6	-0.0	0.3	-0.1	-1.3	-0.2	-1.0
Diastolic blood pressure, automated reading	0.4	1.4	3.7	0.6	-1.9	-0.0	0.1	1.3	-1.6
Vascular/heart problems diagnosed by doctor	0.4	1.1	4.6	0.9	0.7	0.5	0.7	0.4	2.2
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.4	0.5	-1.2	0.3	-0.0	0.9	-1.0
Leg fat mass (left)	0.4	1.4	5.7	-0.5	-2.4	-1.0	0.1	0.0	-1.3
Bipolar Disorder (2018)	0.3	0.5	1.1	1.1	-0.7	-0.6	-0.7	0.5	-0.5
Depression (Nagel 2018)	0.3	0.5	1.5	-0.6	1.0	0.2	0.1	0.4	1.2
Irritable Bowel Disease (IBD)	0.3	0.6	1.5	1.2	0.0	0.6	-1.1	0.3	0.7
Breast Cancer	0.3	0.8	3.0	0.3	1.7	0.4	-0.1	0.6	1.0
Ovarian Cancer	0.3	0.4	1.4	0.1	-0.1	1.2	1.0	0.3	0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	-0.6	-0.3	0.5	-0.2	-0.0	1.2
Crohns Disease (2012)	0.3	0.4	1.5	-0.3	0.1	-0.3	-0.9	0.1	-1.2
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.9	-0.5	-0.1	-1.0	-0.7	-0.1
Rheumatoid Arthritis	0.3	0.4	1.0	0.7	1.0	0.2	-0.6	0.7	-0.3
Triglycerides	0.3	0.5	0.9	-0.9	-0.5	-0.9	-0.6	-0.7	-0.7
Blood Eosinophil Count	0.3	2.6	8.1	0.4	-1.2	-0.5	2.8	0.8	-2.2
Vitamin and mineral supplements	0.3	0.4	1.0	0.5	0.3	-1.0	-0.9	-0.5	-0.0
Sitting height	0.3	2.2	4.3	1.1	-1.0	0.6	2.1	1.8	-1.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	-1.2	-0.3	-0.3	-0.4	-0.3	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.0	0.4	0.6	0.3	1.0	0.4	-0.4
Pain all over the body in last month	0.3	0.4	0.9	-0.9	0.2	0.7	-0.3	0.0	0.8
Asthma	0.3	0.7	1.9	0.5	1.4	0.9	0.2	-0.1	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.5	-0.3	1.6	1.4	0.5	-0.2	1.1
Breastfed as a baby	0.3	0.4	1.2	0.6	1.1	-0.5	0.1	-0.8	0.1
Tense / ‘highly strung’	0.3	0.6	2.2	1.5	-0.2	-0.4	0.2	0.5	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.0	-0.4	0.8	0.1	-0.2	-1.0	0.3
Forced vital capacity (FVC), Best measure	0.3	0.9	3.0	-0.2	1.2	1.7	0.7	0.2	0.7
Leg fat percentage (right)	0.3	1.0	3.3	-0.4	-1.8	-1.1	-0.4	-0.6	-1.0
Neck or shoulder pain in last month	0.3	0.4	1.2	-0.4	-0.3	1.1	0.9	0.5	0.2
Leg fat mass (right)	0.3	1.3	5.0	-0.4	-2.2	-1.0	0.2	-0.1	-1.2
Comparative height size at age 10	0.3	1.5	3.5	1.1	-1.2	1.1	1.9	1.2	-0.4
Suffer from ‘nerves’	0.3	0.5	0.8	0.7	0.8	0.9	0.1	0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.2	-1.4	0.0	-0.2	-1.5	-0.2	0.2
Ever had bowel cancer screening	0.3	0.3	0.7	-0.6	-0.8	0.2	0.8	-0.0	-0.3
Asthma (self-reported)	0.3	0.6	2.1	0.5	1.5	0.7	0.1	-0.2	0.9
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	0.7	0.7	-0.6	0.1	-0.2	0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.5	-0.8	-1.2	-0.0	0.1	-0.5	-0.2
Basal metabolic rate	0.3	1.6	5.6	-0.1	-2.4	-0.0	1.2	1.1	-1.1
Leg fat percentage (left)	0.3	1.2	4.0	-0.5	-2.0	-1.0	-0.4	-0.3	-1.2
Cholesterol lowering medication	0.3	0.4	1.7	0.3	0.0	0.2	-0.8	-0.3	-1.3
Pain experienced in last month	0.3	0.5	1.6	0.8	0.2	0.1	1.3	0.3	0.7
Supplements: Calcium	0.3	0.3	0.7	0.3	0.4	0.8	0.7	0.6	0.3
Worry (Nagel 2018)	0.2	0.3	0.6	0.7	0.5	0.3	-0.5	0.4	0.8
Bipolar Disorder (2011)	0.2	0.2	0.6	0.0	0.0	-0.8	-0.6	0.5	0.0
Schizophrenia (2014)	0.2	0.5	2.0	-0.7	1.4	-0.0	-0.3	-0.2	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.1	0.7	0.7	-0.1	-0.4	-0.0
BMI	0.2	1.4	5.5	0.0	-2.3	-0.9	-1.0	0.2	-0.9
Systolic Blood Pressure	0.2	0.9	3.6	-0.1	-0.3	-0.2	-1.4	0.1	-1.9
Cardiovascular Disease	0.2	0.6	2.0	-1.4	0.5	0.1	-1.1	-0.4	-0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.2	0.0	0.2	0.5	-1.1	-0.8	0.3
Lung FEV1/FVC ratio	0.2	0.8	2.3	0.1	0.9	-0.2	-1.2	-0.5	1.5
Lung FVC	0.2	0.8	2.6	-1.6	-1.0	-0.2	0.6	-0.8	-0.6
Impedance of leg (right)	0.2	1.2	2.9	-0.2	1.3	-0.7	-1.4	-1.7	-0.2
Leg fat-free mass (left)	0.2	1.0	2.3	0.4	-1.5	0.4	1.3	1.3	-0.3
Average weekly fortified wine intake	0.2	0.2	1.0	-0.3	-0.2	0.2	1.0	-0.0	-0.5
Taking other prescription medications	0.2	0.4	1.2	-0.2	-0.1	1.1	0.9	0.5	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.1	-0.5	-0.4	-0.8	-0.6	-1.1	-0.5
High blood pressure (mother)	0.2	0.3	0.8	0.5	-0.5	-0.7	-0.2	0.0	-0.9
Body mass index (BMI)	0.2	0.9	4.5	-0.4	-2.1	-0.7	0.3	0.1	-0.6
Impedance of leg (left)	0.2	0.9	2.0	-0.3	0.8	-0.8	-1.4	-1.3	-0.7
Leg predicted mass (left)	0.2	1.0	2.4	0.4	-1.5	0.4	1.3	1.3	-0.3
Medication: Simvastatin	0.2	0.3	1.2	0.3	1.1	0.3	-0.2	-0.4	0.1
Weight	0.2	1.1	5.1	-0.0	-2.2	-0.2	0.6	0.6	-1.0
Number of live births	0.2	0.3	1.5	-0.1	-0.1	-0.2	-1.2	-0.6	0.0
Happiness	0.2	0.3	0.6	0.4	0.8	0.3	-0.5	0.7	-0.4
Noisy workplace	0.2	0.2	0.6	-0.4	-0.3	0.5	-0.2	0.8	-0.4
Arm fat mass (right)	0.2	0.7	2.8	-0.1	-1.7	-0.8	-0.3	0.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.8	-0.4	0.3	0.8	0.3	-0.0
Birth weight of first child	0.2	0.4	0.9	0.9	-0.5	0.7	0.1	0.9	0.1
Medication: Paracetamol	0.2	0.3	0.9	-0.5	0.1	0.0	0.6	0.1	1.0
Glaucoma (self-reported)	0.2	0.3	0.7	0.6	0.8	-0.6	0.3	-0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.4	-0.2	-1.2	-0.2	0.0	0.0	-0.5
Age at first live birth	0.2	0.3	0.7	0.2	-0.8	-0.9	0.4	-0.2	-0.3
Whole body fat mass	0.2	1.0	4.2	0.2	-2.0	-0.7	-0.1	0.3	-1.0
Pulse rate, automated reading	0.2	0.7	1.8	-0.3	-0.8	-1.0	0.8	0.4	-1.3
Alcohol intake frequency.	0.2	0.5	1.9	-0.4	-0.6	0.3	1.4	0.4	0.6
Overall health rating	0.2	0.5	1.1	-1.0	-0.3	0.5	0.9	0.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.5	-0.1	-0.1	0.9	0.0	-0.6
Leg fat-free mass (right)	0.2	1.2	2.7	0.4	-1.6	0.4	1.2	1.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	-0.0	-0.9	-0.4	0.3	0.4	-0.3
Mineral and other dietary supplements	0.2	0.2	0.9	-0.0	0.3	-1.0	0.2	-0.3	-0.2
Leg predicted mass (right)	0.2	1.2	2.8	0.4	-1.7	0.4	1.2	1.5	-0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.5	-0.0	0.1	0.6	0.7	-0.8
Wears glasses or contact lenses	0.2	0.2	0.4	0.2	0.7	0.3	0.7	0.2	-0.6
High cholesterol (Self-reported)	0.2	0.4	1.1	0.6	0.5	1.0	-0.4	0.1	0.6
Medication: Paracetamol	0.2	0.3	1.0	-0.7	-0.0	-0.0	0.7	-0.1	1.0
Medication: Atorvastatin	0.2	0.2	0.7	0.3	0.0	0.8	-0.7	-0.3	-0.2
Ever depressed for a whole week	0.2	0.3	0.9	-1.0	0.3	0.3	0.7	-0.3	0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	1.0	0.2	1.0	-0.2	-0.8	-0.0	0.5
Respiratory disease	0.1	0.3	0.5	0.7	0.3	-0.1	-0.6	-0.5	-0.7
Hair Pigment	0.1	1.7	6.7	-0.4	0.1	1.4	1.2	-0.2	2.6
Tanning	0.1	1.3	2.5	-1.4	-0.6	-1.6	-0.8	-1.2	-1.0
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.7	0.4	0.6	-0.2	0.0	-0.3
Multivitamins +/- minerals	0.1	0.2	0.6	-0.2	-0.1	0.3	0.8	-0.0	0.4
Chronic bronchitis/emphysema (father)	0.1	0.2	0.5	-0.0	0.4	0.1	0.7	0.4	0.4
Trunk fat mass	0.1	0.4	1.8	0.4	-1.3	-0.3	-0.3	0.5	-0.5
Number of incorrect matches in round	0.1	0.2	0.6	0.6	-0.3	0.4	-0.0	0.8	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.0	0.3	-0.2	-0.2	-1.0	-0.7	-0.5
Arm fat percentage (right)	0.1	0.3	0.9	0.5	-0.4	-0.5	-0.9	-0.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.4	-0.4	0.7	0.6	-0.2	-0.4	0.0
Pulse rate	0.1	0.2	0.7	-0.1	0.5	0.4	0.8	-0.4	0.0
Standing height	0.1	0.6	1.0	0.7	-0.4	0.7	0.6	1.0	-1.0
Peak expiratory flow (PEF)	0.1	0.2	1.0	0.4	0.2	1.0	0.2	-0.0	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.9	-0.1	0.1	0.9	-0.0	-0.2	0.4
Body fat percentage	0.1	0.4	0.9	0.5	-0.9	-0.6	-0.7	-0.0	-0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.2	0.7	0.5	0.2	-0.0	0.7
Number of children fathered	0.1	0.1	0.5	-0.3	0.7	0.1	-0.3	-0.3	0.2
Migraine (self-reported)	0.1	0.1	0.3	0.2	0.5	0.4	-0.6	-0.1	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.2	-0.2	0.4	-0.5	-0.1	-0.3
Arm fat percentage (left)	0.1	0.3	1.0	0.2	-0.3	-0.5	-1.0	-0.2	0.5
Friendships satisfaction	0.1	0.1	0.4	-0.4	-0.2	0.1	0.6	0.1	-0.4
Back pain experienced in last month	0.1	0.2	0.5	-0.4	0.0	0.7	0.1	0.7	-0.1
Arm fat mass (left)	0.1	0.4	1.7	0.1	-1.3	-0.4	-0.0	0.3	-0.3
Guilty feelings	0.1	0.1	0.2	-0.2	0.4	0.4	-0.0	0.4	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Height	0.0	0.7	1.6	0.5	0.6	1.3	-0.4	1.2	-0.4
Trunk fat percentage	0.0	0.2	0.5	0.6	-0.4	-0.3	-0.7	0.1	0.1
Forced vital capacity (FVC)	0.0	0.2	0.8	-0.3	0.2	0.9	0.2	-0.2	-0.1
Hair/balding pattern: Pattern 3	0.0	0.1	0.2	0.1	0.3	-0.5	-0.3	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.3	-0.1	0.1	-0.2	0.5	0.2	-0.2
Alcohol drinker status: Previous	0.0	0.0	0.2	0.0	-0.2	0.1	0.1	0.5	0.2

Hub : Genes

PANX2

Models

Trait associations