Hub : Genes

PANX2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1600	0.0640	0.0044	0.012	NA	0.030	NA	-0.001	7.0e-02	NA	8.4e-03	NA	3.9e-01
2	YFS	Blood	0.2205	0.0362	0.0000	0.067	0.121	0.123	0.124	0.110	5.3e-21	2.6e-37	3.7e-38	3e-38	5.5e-34
3	TCGA	Cervical Squamous Cell Carcinoma	0.1230	0.0650	0.0028	0.075	0.043	0.035	NA	0.072	1.5e-04	3.4e-03	7.6e-03	NA	2.1e-04
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0462	0.0249	0.0053	0.020	0.013	0.013	NA	0.017	2.3e-03	1.2e-02	1.0e-02	NA	4.8e-03
5	TCGA	Liver Hepatocellular Carcinoma	0.1170	0.0580	0.0015	0.054	0.098	0.070	NA	0.073	1.5e-03	2.4e-05	3.5e-04	NA	2.6e-04
6	TCGA	Lung Adenocarcinoma	0.0379	0.0241	0.0088	0.016	0.001	0.021	NA	0.004	5.4e-03	2.5e-01	1.5e-03	NA	1.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.1	1.1	-0.7	-0.6	-0.7	0.5	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.3	1.0	0.2	1.0	-0.2	-0.8	-0.0	0.5
Depressed Affect (Nagel 2018)	1.9	4.1	7.8	1.9	1.1	2.8	0.8	2.3	2.4
Depression (Nagel 2018)	0.3	0.5	1.5	-0.6	1.0	0.2	0.1	0.4	1.2
Intelligence (Savage-Jansen 2018)	1.1	3.4	11.0	2.1	0.3	-1.1	1.5	1.3	-3.3
Neuroticism (Nagel 2018)	0.8	1.8	3.0	1.1	1.0	1.7	0.4	1.7	1.6
Schizophrenia (2018)	0.4	0.9	3.4	-0.5	1.8	0.3	-0.4	-0.4	1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	-0.4	1.1	0.4	0.0	-0.7	0.8
Worry (Nagel 2018)	0.2	0.3	0.6	0.7	0.5	0.3	-0.5	0.4	0.8
Alzheimer’s Disease (in mother)	1.3	1.5	4.9	-2.2	0.1	-0.1	1.9	-0.2	-0.4
Alzheimer’s Disease (in father)	1.4	1.6	4.8	0.3	-1.9	-0.6	0.1	0.8	-2.2
Alzheimer’s Disease (including proxy)	1.0	1.4	3.6	-1.2	-0.8	-0.1	1.5	0.8	-1.9
Crohns Disease (2017)	0.4	0.8	1.9	0.2	-0.4	-1.2	-1.4	-0.1	-1.0
Irritable Bowel Disease (IBD)	0.3	0.6	1.5	1.2	0.0	0.6	-1.1	0.3	0.7
Ulcerative Colitis (UC)	0.9	1.6	3.4	1.6	0.6	1.5	-1.1	0.1	1.8
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.8	1.5	4.2	-2.1	-0.4	-1.1	-0.1	-1.5	1.0
Verbal and Numeric Reasoning (VNR)	1.4	3.4	10.0	2.0	-0.5	-0.2	1.3	2.1	-3.2
Breast Cancer	0.3	0.8	3.0	0.3	1.7	0.4	-0.1	0.6	1.0
Ovarian Cancer	0.3	0.4	1.4	0.1	-0.1	1.2	1.0	0.3	0.1
Prostate Cancer	0.9	1.3	5.2	-2.3	0.2	-0.4	0.5	-0.7	1.3
Age at First Birth	0.5	0.7	2.2	1.5	-0.2	0.5	0.1	1.0	-0.7
Bipolar Disorder (2011)	0.2	0.2	0.6	0.0	0.0	-0.8	-0.6	0.5	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	-0.6	-0.3	0.5	-0.2	-0.0	1.2
Coronary Artery Disease (CAD)	0.6	0.7	1.8	0.0	0.0	1.2	0.8	0.2	1.4
Crohns Disease (2012)	0.3	0.4	1.5	-0.3	0.1	-0.3	-0.9	0.1	-1.2
Mean Putamen Volume	0.5	0.6	1.0	0.3	-0.8	-1.0	-0.9	-0.9	-0.4
Fasting Glucose	1.5	1.8	5.1	-0.9	1.2	0.8	-2.3	-0.8	1.5
HbA1C	0.6	0.7	1.6	0.1	0.7	1.1	-0.2	1.3	0.9
HDL Cholesterol	0.5	0.9	1.9	-1.1	1.4	-0.5	0.1	-0.8	1.2
LDL Cholesterol	0.5	0.7	2.3	-0.9	0.4	-0.0	0.2	-1.0	1.5
Lupus	0.6	1.0	3.5	0.5	-0.1	-0.5	-1.4	-0.1	-1.9
Neuroticism (2016)	0.4	0.6	2.3	-0.8	-0.4	-0.2	-1.5	-0.5	0.6
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.9	-0.5	-0.1	-1.0	-0.7	-0.1
Rheumatoid Arthritis	0.3	0.4	1.0	0.7	1.0	0.2	-0.6	0.7	-0.3
Schizophrenia (2014)	0.2	0.5	2.0	-0.7	1.4	-0.0	-0.3	-0.2	0.6
Triglycerides	0.3	0.5	0.9	-0.9	-0.5	-0.9	-0.6	-0.7	-0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.1	0.7	0.7	-0.1	-0.4	-0.0
Ulcerative Colitis	0.9	1.3	3.1	0.8	1.1	1.5	-0.6	0.1	1.8
Blood Eosinophil Count	0.3	2.6	8.1	0.4	-1.2	-0.5	2.8	0.8	-2.2
Blood Platelet Count	2.2	26.1	68.2	1.3	-1.4	5.7	8.3	7.1	-1.6
Blood Red Count	1.0	9.7	21.3	-1.5	-4.6	-3.4	-3.4	-2.5	-2.1
Blood White Count	0.7	5.4	11.7	0.6	-3.4	-0.4	2.6	2.6	-2.6
Heel T-Score	0.6	4.4	11.0	0.1	-1.8	-2.3	-3.3	-1.3	-2.2
BMI	0.2	1.4	5.5	0.0	-2.3	-0.9	-1.0	0.2	-0.9
Height	0.0	0.7	1.6	0.5	0.6	1.3	-0.4	1.2	-0.4
Waist Hip Ratio (WHR)	0.5	2.4	7.3	2.7	0.1	0.9	1.8	1.3	1.2
Systolic Blood Pressure	0.2	0.9	3.6	-0.1	-0.3	-0.2	-1.4	0.1	-1.9
Smoking Status	1.9	4.7	9.4	2.5	0.4	3.1	1.8	2.8	1.0
Allergy or Eczema	0.5	1.2	3.8	-0.0	-0.2	-1.5	-0.8	-0.8	-1.9
Cardiovascular Disease	0.2	0.6	2.0	-1.4	0.5	0.1	-1.1	-0.4	-0.5
Hypothyroidism (self reported)	1.0	2.2	8.4	-2.9	-0.4	-0.9	-0.9	-1.5	-1.0
Respiratory disease	0.1	0.3	0.5	0.7	0.3	-0.1	-0.6	-0.5	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.2	0.0	0.2	0.5	-1.1	-0.8	0.3
Lung FEV1/FVC ratio	0.2	0.8	2.3	0.1	0.9	-0.2	-1.2	-0.5	1.5
Lung FVC	0.2	0.8	2.6	-1.6	-1.0	-0.2	0.6	-0.8	-0.6
Neuroticism	1.3	3.1	5.7	2.4	1.2	2.2	-0.1	2.0	1.4
Chronotype (morning person)	0.8	1.9	6.7	1.2	-2.6	-0.2	0.1	0.7	-1.6
Hair Pigment	0.1	1.7	6.7	-0.4	0.1	1.4	1.2	-0.2	2.6
Tanning	0.1	1.3	2.5	-1.4	-0.6	-1.6	-0.8	-1.2	-1.0
Hand grip strength (left)	1.4	3.6	7.3	-1.0	-1.6	-1.9	-2.3	-1.2	-2.7
Number of treatments/medications taken	0.4	0.7	2.4	-1.6	0.6	0.5	-0.7	-0.7	0.3
Average weekly spirits intake	1.0	1.2	2.6	-1.5	-0.1	-1.0	-0.5	-1.6	1.1
Sensitivity / hurt feelings	0.7	1.2	3.4	0.1	-0.5	-0.7	-1.5	0.8	-1.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.9	0.6	1.4	0.2	-0.4	0.4	1.1
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.7	0.4	0.6	-0.2	0.0	-0.3
Relative age of first facial hair	1.1	2.3	3.1	1.1	-1.7	1.8	1.6	1.3	1.6
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	5.2	1.0	-0.8	0.2	2.3	1.2	0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.1	-0.3	-0.7	1.1	-0.5	-1.0
Ever had hysterectomy (womb removed)	1.4	1.5	4.9	1.1	-0.4	2.2	1.0	0.8	1.2
Systolic blood pressure, automated reading	0.5	1.5	4.3	0.3	-1.9	0.1	-0.6	0.8	-2.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.2	-1.1	-0.1	-0.6	-0.6	-0.7	0.5
Angina	0.4	0.5	1.3	-1.0	-0.6	0.1	1.1	0.4	-0.4
Medication for hormone replacement therapy	0.6	0.6	2.2	-0.1	-1.5	0.2	0.3	-0.1	-1.1
Vitamin and mineral supplements	0.3	0.4	1.0	0.5	0.3	-1.0	-0.9	-0.5	-0.0
Supplements: Zinc	0.5	0.5	1.6	0.2	-1.3	-0.6	0.8	-0.5	-0.3
Medication: Co-codamol	1.5	1.8	6.3	-0.7	-2.5	-1.0	1.1	0.1	-1.2
Medication: Metformin	1.1	1.5	4.7	-1.0	1.0	1.3	0.1	-0.7	2.2
Diabetes (father)	0.4	0.5	1.8	1.4	0.1	0.3	0.1	-0.4	0.9
Diabetes (mother)	1.0	1.2	2.6	-1.0	-1.6	-0.5	-1.2	-1.4	-0.4
Severe depression (siblings)	0.5	0.6	2.7	-1.6	0.2	-0.4	-0.5	-0.5	-0.0
Pack years adult smoking proportion	1.3	2.0	4.0	2.0	0.4	1.2	1.8	1.6	0.6
Impedance of leg (right)	0.2	1.2	2.9	-0.2	1.3	-0.7	-1.4	-1.7	-0.2
Leg fat-free mass (left)	0.2	1.0	2.3	0.4	-1.5	0.4	1.3	1.3	-0.3
Trunk fat percentage	0.0	0.2	0.5	0.6	-0.4	-0.3	-0.7	0.1	0.1
Hand grip strength (right)	1.0	2.7	6.6	-0.7	-1.5	-1.4	-2.0	-1.2	-2.6
Townsend deprivation index at recruitment	1.0	1.3	2.7	1.5	-1.1	1.1	0.8	1.6	-0.3
Current tobacco smoking	3.1	5.1	10.5	1.7	-0.4	2.9	2.8	3.2	0.5
Average weekly fortified wine intake	0.2	0.2	1.0	-0.3	-0.2	0.2	1.0	-0.0	-0.5
Maternal smoking around birth	2.3	3.3	10.9	1.3	-1.1	1.9	3.3	1.5	0.1
Fed-up feelings	1.2	2.1	5.9	1.8	-0.1	2.4	-0.3	1.7	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.4	-0.4	0.4	1.1	0.6	0.4	1.2
Relative age voice broke	0.6	0.9	2.3	-0.6	-0.9	-0.8	-1.1	-1.5	-0.0
Taking other prescription medications	0.2	0.4	1.2	-0.2	-0.1	1.1	0.9	0.5	-0.1
Age when periods started (menarche)	0.7	1.8	4.4	-1.0	1.4	-1.7	-0.6	-2.1	-0.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.0	0.6	-1.5	2.0	0.5	0.4	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.1	1.1	-0.1	-1.0	-1.2	-0.3	-1.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.0	0.7	0.0	-0.9	0.1	-0.2	-1.7
Qualifications: CSEs or equivalent	2.1	2.8	9.6	-1.1	1.4	0.0	-0.9	-1.8	3.1
Serious illness, injury or assault to yourself	0.6	0.7	1.8	-0.4	-1.3	-1.1	-0.0	-0.6	0.7
High blood pressure	0.4	1.1	4.2	-0.8	-0.4	-0.4	-1.1	-0.7	-2.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.1	-0.5	-0.4	-0.8	-0.6	-1.1	-0.5
Multivitamins +/- minerals	0.1	0.2	0.6	-0.2	-0.1	0.3	0.8	-0.0	0.4
Stomach or abdominal pain in last month	0.9	1.2	2.4	-0.6	0.7	-0.8	-1.6	-1.3	1.2
Supplements: Glucosamine	0.5	0.6	1.2	-0.6	1.0	1.1	-0.6	-0.0	0.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	-0.2	1.2	-1.2	0.4	-1.3	0.4
Medication: Atenolol	0.4	0.5	1.0	-0.9	-1.0	-0.7	-0.6	-0.6	-0.4
Medication: Levothyroxine sodium	0.7	1.1	3.4	-1.8	-1.2	-0.4	-0.3	-0.5	-1.3
Sitting height	0.3	2.2	4.3	1.1	-1.0	0.6	2.1	1.8	-1.8
Chronic bronchitis/emphysema (father)	0.1	0.2	0.5	-0.0	0.4	0.1	0.7	0.4	0.4
High blood pressure (mother)	0.2	0.3	0.8	0.5	-0.5	-0.7	-0.2	0.0	-0.9
Body mass index (BMI)	0.2	0.9	4.5	-0.4	-2.1	-0.7	0.3	0.1	-0.6
Impedance of leg (left)	0.2	0.9	2.0	-0.3	0.8	-0.8	-1.4	-1.3	-0.7
Leg predicted mass (left)	0.2	1.0	2.4	0.4	-1.5	0.4	1.3	1.3	-0.3
Trunk fat mass	0.1	0.4	1.8	0.4	-1.3	-0.3	-0.3	0.5	-0.5
Waist circumference	0.4	1.5	7.4	0.5	-2.7	-0.4	0.6	0.4	-0.8
Number of incorrect matches in round	0.1	0.2	0.6	0.6	-0.3	0.4	-0.0	0.8	0.2
Past tobacco smoking	0.7	1.3	2.5	-1.2	-0.3	-1.4	-1.6	-1.2	-0.5
Alcohol usually taken with meals	0.8	1.2	4.1	-0.2	0.0	-1.3	-1.1	0.3	-2.0
Nervous feelings	0.4	0.7	1.7	1.1	-0.4	-0.8	-1.3	0.3	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.8	-0.3	1.1	0.7	-1.2	-0.5	1.4
Hearing difficulty/problems with background noise	0.9	1.4	3.4	-0.9	1.3	0.0	-1.1	-1.8	1.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	-1.2	-0.3	-0.3	-0.4	-0.3	0.4
Had menopause	1.1	1.3	4.6	0.8	-1.1	-0.5	0.4	1.1	-2.1
Had other major operations	1.4	1.7	5.1	0.3	-1.6	-0.9	-0.6	1.1	-2.3
Forced vital capacity (FVC)	0.0	0.2	0.8	-0.3	0.2	0.9	0.2	-0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.0	0.3	-0.2	-0.2	-1.0	-0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.0	0.4	0.6	0.3	1.0	0.4	-0.4
Qualifications: None of the above	1.0	2.2	4.6	-0.1	-2.1	2.1	0.8	1.9	-0.1
Financial difficulties in last 2 years	0.5	0.7	1.5	-0.6	-1.1	-1.2	0.1	-0.2	-1.0
Mouth/teeth dental problems	0.7	1.1	2.3	0.7	-0.5	-1.1	-1.5	-0.6	-1.3
Heart attack	0.6	0.8	1.9	0.5	-1.4	0.4	0.0	1.0	-1.1
Allergy	0.4	0.9	2.1	0.8	-0.5	1.0	1.3	1.4	0.3
Pain all over the body in last month	0.3	0.4	0.9	-0.9	0.2	0.7	-0.3	0.0	0.8
Diabetes (self-reported)	0.8	1.2	2.9	0.8	0.9	1.7	-0.3	-0.5	1.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.7	-1.3	0.5	0.5	-0.5	-0.8	0.9
Medication: Ramipril	1.2	1.5	4.1	2.0	-0.4	1.8	0.5	1.1	-0.0
Medication: Simvastatin	0.2	0.3	1.2	0.3	1.1	0.3	-0.2	-0.4	0.1
Fluid intelligence score	0.6	1.3	3.9	1.0	0.1	-0.5	1.3	1.1	-2.0
Illnesses of siblings	0.7	1.0	2.7	1.6	1.2	0.0	0.9	0.6	-0.8
Neuroticism score	0.6	1.3	3.0	1.7	-0.0	1.4	-0.6	1.5	0.2
Weight	0.2	1.1	5.1	-0.0	-2.2	-0.2	0.6	0.6	-1.0
Impedance of arm (right)	0.9	4.3	14.2	1.5	3.8	0.5	-2.2	-0.8	1.9
Arm fat percentage (right)	0.1	0.3	0.9	0.5	-0.4	-0.5	-0.9	-0.1	0.3
Trunk fat-free mass	0.4	2.4	7.7	-0.2	-2.8	-0.1	1.5	1.2	-1.8
Hip circumference	0.4	1.5	7.1	-0.1	-2.7	0.0	0.6	0.7	-1.1
Time employed in main current job	1.0	1.2	3.1	-1.7	0.2	-0.5	-1.8	-0.4	-0.7
Alcohol intake versus 10 years previously	1.0	1.6	4.2	-1.2	-2.0	-1.0	0.3	-1.6	-0.1
Father’s age at death	0.9	1.2	1.8	1.2	-1.0	-1.3	-0.9	-0.0	-1.4
Worrier / anxious feelings	0.4	0.7	1.8	0.7	0.8	1.0	-1.3	0.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.1	-0.6	1.0	1.4	-0.3	0.7	1.0
Falls in the last year	1.9	2.5	4.8	1.9	0.6	2.2	1.4	2.0	0.9
Hair/balding pattern: Pattern 3	0.0	0.1	0.2	0.1	0.3	-0.5	-0.3	-0.2	0.1
Number of live births	0.2	0.3	1.5	-0.1	-0.1	-0.2	-1.2	-0.6	0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.4	-0.4	0.7	0.6	-0.2	-0.4	0.0
Pulse rate	0.1	0.2	0.7	-0.1	0.5	0.4	0.8	-0.4	0.0
Happiness	0.2	0.3	0.6	0.4	0.8	0.3	-0.5	0.7	-0.4
Noisy workplace	0.2	0.2	0.6	-0.4	-0.3	0.5	-0.2	0.8	-0.4
Qualifications: A levels/AS levels or equivalent	0.8	1.9	7.1	0.3	0.2	-1.7	-1.1	-0.0	-2.7
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.3	0.4	1.2	-0.5	0.7	0.3	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.7	2.4	1.0	0.7	0.5	1.6	0.6	0.1
Asthma	0.3	0.7	1.9	0.5	1.4	0.9	0.2	-0.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	5.4	1.4	-0.6	2.0	1.3	2.3	-0.7
Medication: Cholesterol lowering	0.4	0.6	1.4	-0.2	0.8	0.9	-0.7	-0.5	1.2
Depression (self-reported)	0.7	0.8	2.5	0.1	-0.6	0.9	0.9	1.6	-0.7
Medication: Lansoprazole	1.0	1.1	2.6	1.3	0.7	-0.2	0.7	1.1	-1.6
Prospective memory result	1.0	1.2	4.0	0.8	-0.6	0.5	2.0	0.7	1.3
Lung cancer (father)	1.5	1.8	5.0	-1.5	-0.1	-1.7	-0.7	-2.2	0.5
Illnesses of mother	0.4	0.5	1.5	1.2	-0.3	0.4	-0.8	0.7	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.5	-0.3	1.6	1.4	0.5	-0.2	1.1
Pulse wave Arterial Stiffness index	0.6	0.7	2.5	-1.1	0.7	-0.0	-1.6	-0.1	-0.1
Impedance of arm (left)	1.1	5.2	16.8	1.2	4.1	0.6	-2.4	-1.1	2.4
Arm fat mass (right)	0.2	0.7	2.8	-0.1	-1.7	-0.8	-0.3	0.2	-0.7
Trunk predicted mass	0.4	2.3	7.5	-0.3	-2.7	-0.2	1.4	1.1	-1.8
Standing height	0.1	0.6	1.0	0.7	-0.4	0.7	0.6	1.0	-1.0
Length of working week for main job	1.1	1.2	2.0	0.4	-1.4	-1.4	-1.2	-0.1	-1.3
Exposure to tobacco smoke at home	1.6	1.8	5.8	2.4	-0.1	-1.3	-1.0	0.1	-1.5
Breastfed as a baby	0.3	0.4	1.2	0.6	1.1	-0.5	0.1	-0.8	0.1
Tense / ‘highly strung’	0.3	0.6	2.2	1.5	-0.2	-0.4	0.2	0.5	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.8	-0.4	0.3	0.8	0.3	-0.0
Hair/balding pattern: Pattern 4	1.0	2.4	7.9	0.6	-0.5	-1.8	-1.6	-0.3	-2.8
Birth weight of first child	0.2	0.4	0.9	0.9	-0.5	0.7	0.1	0.9	0.1
Peak expiratory flow (PEF)	0.1	0.2	1.0	0.4	0.2	1.0	0.2	-0.0	-0.4
Pulse wave reflection index	1.1	1.4	4.4	-0.6	1.7	-0.7	-2.1	-0.4	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	-0.6	1.0	0.7	0.6	0.5	-0.8
Loud music exposure frequency	0.8	0.9	2.5	-0.9	1.6	0.1	1.0	-0.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.8	-0.3	1.0	-1.7	-1.1	-0.7	-0.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.4	-1.6	1.0	0.7	0.0	-0.6	1.4
Blood clot in the leg (DVT)	1.0	1.3	3.6	-0.6	1.4	1.2	0.6	-0.2	1.9
Medication: Paracetamol	0.2	0.3	0.9	-0.5	0.1	0.0	0.6	0.1	1.0
Headache pain in last month	0.4	0.7	2.0	-0.2	1.4	0.9	0.6	-0.0	1.0
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.3	-0.1	0.1	-0.2	0.5	0.2	-0.2
Glaucoma (self-reported)	0.2	0.3	0.7	0.6	0.8	-0.6	0.3	-0.2	-0.1
Gout (self-reported)	0.5	0.6	1.6	-0.3	1.3	1.0	-0.6	-0.1	1.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	6.6	-2.6	-1.5	-1.1	-1.1	-1.2	-1.8
Medication: Amlodipine	0.6	0.8	3.2	0.2	-0.9	-0.3	-0.7	-0.1	-1.8
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.9	-0.1	0.1	0.9	-0.0	-0.2	0.4
Birth weight	0.9	2.0	7.0	0.4	-2.6	0.2	1.1	1.6	-0.9
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.0	-0.4	0.8	0.1	-0.2	-1.0	0.3
High blood pressure (siblings)	0.4	0.6	1.9	-0.9	-0.8	-0.3	-1.4	-0.4	0.3
Forced vital capacity (FVC), Best measure	0.3	0.9	3.0	-0.2	1.2	1.7	0.7	0.2	0.7
Body fat percentage	0.1	0.4	0.9	0.5	-0.9	-0.6	-0.7	-0.0	-0.4
Leg fat percentage (right)	0.3	1.0	3.3	-0.4	-1.8	-1.1	-0.4	-0.6	-1.0
Arm fat-free mass (right)	0.6	2.9	9.7	-0.4	-3.1	-0.3	1.5	1.2	-2.0
Exposure to tobacco smoke outside home	1.7	2.3	5.3	2.3	1.4	1.4	0.2	1.8	1.0
Comparative body size at age 10	0.4	1.1	2.1	1.2	0.3	1.4	-0.2	1.2	1.3
Number of full brothers	0.5	0.6	1.4	-1.1	0.1	0.1	-1.1	-1.2	-0.0
Worry too long after embarrassment	0.6	1.0	3.1	-0.3	0.7	1.4	0.5	0.3	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.4	-0.2	-1.2	-0.2	0.0	0.0	-0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.2	0.7	0.5	0.2	-0.0	0.7
Number of children fathered	0.1	0.1	0.5	-0.3	0.7	0.1	-0.3	-0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.2	0.1	-0.3	2.0	1.5	1.1	0.9
Age at first live birth	0.2	0.3	0.7	0.2	-0.8	-0.9	0.4	-0.2	-0.3
Pulse wave peak to peak time	0.7	0.8	2.6	1.3	-0.6	0.2	1.6	0.3	-0.0
Health satisfaction	0.6	0.8	1.7	-1.3	-0.9	-0.7	0.2	-0.1	-1.2
Shortness of breath walking on level ground	0.5	0.6	1.8	-0.1	-1.3	0.4	1.0	0.8	0.2
Qualifications: College or University degree	1.2	3.6	7.5	-0.1	0.0	-2.7	-2.6	-0.8	-2.6
Eye problems/disorders: None of the above	1.3	1.5	3.5	1.2	0.3	1.3	0.9	1.9	-1.2
Mouth/teeth dental problems: Loose teeth	2.1	2.5	4.3	0.6	-1.5	1.9	2.0	2.1	0.2
Emphysema/chronic bronchitis	2.8	3.1	7.2	-0.8	-2.7	-1.4	-1.5	0.5	-2.6
Medication for pain relief, constipation, heartburn	0.5	0.9	3.3	-0.1	-0.6	-1.8	-0.3	-1.0	-0.6
Neck or shoulder pain in last month	0.3	0.4	1.2	-0.4	-0.3	1.1	0.9	0.5	0.2
Medication: Blood pressure	0.6	1.0	3.3	0.1	-1.8	-0.2	-0.4	0.3	-1.5
Angina (self-reported)	0.4	0.6	1.3	-1.0	-0.8	0.2	1.1	0.4	-0.6
Migraine (self-reported)	0.1	0.1	0.3	0.2	0.5	0.4	-0.6	-0.1	-0.1
Medication: Ibuprofen	1.4	1.6	3.5	1.4	-0.8	1.4	1.2	1.9	-0.7
Medication: Allopurinol	0.8	1.0	3.2	-0.5	0.5	1.8	0.4	0.4	1.4
Medication: Omeprazole	1.8	2.1	4.3	-2.0	1.0	-0.9	-0.9	-2.1	1.4
Medication: Seretide 50 evohaler	0.5	0.6	3.1	1.8	0.1	0.2	0.4	0.1	0.5
Mean time to correctly identify matches	1.0	1.8	4.0	-2.0	-1.9	-1.2	0.3	-1.5	0.1
Heart disease (mother)	2.1	2.6	5.4	-2.3	1.3	-0.8	-1.4	-2.1	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.9	-0.8	0.2	-1.4	-1.7	-1.6	0.1
Whole body fat mass	0.2	1.0	4.2	0.2	-2.0	-0.7	-0.1	0.3	-1.0
Leg fat mass (right)	0.3	1.3	5.0	-0.4	-2.2	-1.0	0.2	-0.1	-1.2
Arm predicted mass (right)	0.6	3.3	10.5	-0.3	-3.2	-0.5	1.8	1.1	-2.1
Pulse rate, automated reading	0.2	0.7	1.8	-0.3	-0.8	-1.0	0.8	0.4	-1.3
Alcohol intake frequency.	0.2	0.5	1.9	-0.4	-0.6	0.3	1.4	0.4	0.6
Comparative height size at age 10	0.3	1.5	3.5	1.1	-1.2	1.1	1.9	1.2	-0.4
Number of full sisters	0.6	0.7	2.3	-1.1	-0.3	-0.1	0.4	-0.8	1.5
Suffer from ‘nerves’	0.3	0.5	0.8	0.7	0.8	0.9	0.1	0.8	0.3
Overall health rating	0.2	0.5	1.1	-1.0	-0.3	0.5	0.9	0.5	0.6
Chest pain or discomfort	2.0	2.9	7.4	-1.2	2.5	1.2	-0.4	-0.9	2.7
Had major operations	1.3	1.5	5.1	-0.5	-2.3	-1.2	-0.1	-0.5	-1.4
Age at last live birth	0.4	0.6	2.0	0.7	-1.4	-0.5	0.3	0.5	-0.8
Family relationship satisfaction	0.5	0.6	1.4	0.4	0.4	1.1	1.2	0.9	0.0
Leg pain on walking	0.7	0.9	1.2	-1.1	0.9	-0.2	1.1	-1.1	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.5	-1.1	0.3	0.6	-0.0	-1.0	1.2
Commuting to job workplace: Car/motor vehicle	1.5	1.8	2.9	-1.7	-0.3	-1.4	-1.6	-1.6	-0.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.5	1.4	0.8	1.6	0.0	0.3	0.8
Medication: Aspirin	0.5	0.7	1.0	-0.5	0.7	1.0	-1.0	-0.5	1.0
Supplements: Vitamin C	0.4	0.5	2.2	-1.5	0.2	0.1	0.7	-0.6	0.3
Knee pain experienced in last month	0.5	0.8	2.9	-0.2	1.7	-0.4	-0.8	-0.7	0.8
Hypertension (Self-reported)	0.5	1.3	4.5	-1.0	-0.6	-0.5	-1.1	-0.7	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.5	-0.1	-0.1	0.9	0.0	-0.6
Illnesses of father: Heart disease	0.4	0.5	0.7	-0.8	-0.8	0.7	0.8	0.8	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.2	-0.2	0.4	-0.5	-0.1	-0.3
Smoking status: Previous	0.4	0.6	1.0	1.0	0.6	1.0	0.6	0.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.2	-1.4	0.0	-0.2	-1.5	-0.2	0.2
Whole body fat-free mass	0.4	2.0	6.2	-0.0	-2.5	0.1	1.5	1.4	-1.4
Leg fat-free mass (right)	0.2	1.2	2.7	0.4	-1.6	0.4	1.2	1.5	-0.4
Arm fat percentage (left)	0.1	0.3	1.0	0.2	-0.3	-0.5	-1.0	-0.2	0.5
Average weekly red wine intake	1.1	1.7	3.3	-1.2	-0.9	-1.7	-1.8	-0.6	-1.0
Handedness (chirality/laterality): Left-handed	2.3	2.8	7.6	2.8	-1.0	0.9	1.3	2.1	-1.1
Mood swings	1.2	2.3	5.8	1.3	0.4	2.4	-0.8	2.1	0.9
Loneliness, isolation	2.1	2.9	5.4	0.9	0.8	2.3	2.2	0.2	2.3
Long-standing illness, disability or infirmity	0.5	0.8	2.6	-0.8	0.1	0.6	1.6	0.2	1.1
Ever had bowel cancer screening	0.3	0.3	0.7	-0.6	-0.8	0.2	0.8	-0.0	-0.3
Diabetes diagnosed by doctor	0.7	1.2	2.9	0.3	1.0	1.7	0.1	-0.4	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	-0.0	-0.9	-0.4	0.3	0.4	-0.3
Friendships satisfaction	0.1	0.1	0.4	-0.4	-0.2	0.1	0.6	0.1	-0.4
Qualifications: nursing, teaching	1.8	2.7	6.6	-1.0	2.6	-1.8	-0.8	-2.1	0.7
Commuting to job workplace: Walk	3.8	4.1	7.4	2.7	1.0	2.2	2.1	2.4	1.2
Eye problems/disorders: Cataract	1.0	1.1	2.6	-1.1	-0.5	-0.2	-0.8	-1.4	1.6
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	10.3	-0.3	-1.4	1.4	3.2	1.4	1.0
Medication for cholesterol	1.1	1.7	5.3	1.1	0.5	0.6	1.4	1.0	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	0.6	-0.3	0.1	1.3	-0.4	1.2
Back pain experienced in last month	0.1	0.2	0.5	-0.4	0.0	0.7	0.1	0.7	-0.1
Mineral and other dietary supplements	0.2	0.2	0.9	-0.0	0.3	-1.0	0.2	-0.3	-0.2
Breast cancer (self-reported)	1.2	1.4	3.0	-0.6	-1.5	-1.7	-0.9	-0.4	-1.2
Asthma (self-reported)	0.3	0.6	2.1	0.5	1.5	0.7	0.1	-0.2	0.9
Osteoporosis (self-reported)	0.4	0.5	1.8	0.6	-0.6	0.6	0.3	1.3	0.1
Osteoarthritis (self-reported)	0.4	0.5	2.1	0.5	0.2	0.7	0.2	1.4	0.6
Medication: Aspirin	0.4	0.5	1.1	-0.7	0.1	0.1	-1.0	-0.9	0.5
Medication: Gliclazide	2.1	2.4	5.8	-0.7	2.2	2.4	-0.7	0.5	1.5
Illnesses of father: None of the above (group 1)	0.7	0.8	2.3	0.3	1.3	-0.1	0.3	-0.9	1.5
Smoking status: Current	2.5	4.0	8.8	1.3	-0.5	2.7	2.4	3.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.8	-1.9	0.9	-0.1	-0.1	-1.4	1.2
Whole body water mass	0.4	2.0	6.3	-0.1	-2.5	0.0	1.5	1.3	-1.3
Leg predicted mass (right)	0.2	1.2	2.8	0.4	-1.7	0.4	1.2	1.5	-0.4
Arm fat mass (left)	0.1	0.4	1.7	0.1	-1.3	-0.4	-0.0	0.3	-0.3
Number of self-reported non-cancer illnesses	0.6	1.0	2.5	-0.6	-0.7	-0.3	-1.6	-0.3	-1.6
Average weekly champagne plus white wine intake	0.2	0.3	0.7	0.5	-0.0	0.1	0.6	0.7	-0.8
Miserableness	0.4	0.6	2.0	0.1	0.8	0.8	-0.4	0.6	1.4
Guilty feelings	0.1	0.1	0.2	-0.2	0.4	0.4	-0.0	0.4	0.4
Wears glasses or contact lenses	0.2	0.2	0.4	0.2	0.7	0.3	0.7	0.2	-0.6
Ever taken oral contraceptive pill	1.4	1.6	4.0	-0.5	-0.1	-2.0	-1.1	-2.0	-0.7
Hearing aid user	0.7	0.7	1.7	-0.5	-1.3	-0.6	-0.8	-1.1	0.6
Mother’s age at death	0.4	0.5	2.3	0.7	1.5	0.2	0.0	0.4	-0.2
Financial situation satisfaction	0.8	1.0	2.4	0.7	-1.1	1.5	0.4	1.4	-0.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	-1.0	-1.1	0.0	-0.3	-0.6	0.9
Commuting to job workplace: Public transport	2.4	2.9	5.1	1.9	-0.9	0.9	2.3	2.1	-1.6
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	0.7	0.7	-0.6	0.1	-0.2	0.6
Medication: Blood pressure	0.9	1.8	4.8	-1.4	-0.4	-0.9	-1.3	-1.1	-2.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.5	-0.8	-1.2	-0.0	0.1	-0.5	-0.2
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.4	1.0	0.1	1.9	0.9	0.6	1.0
High cholesterol (Self-reported)	0.2	0.4	1.1	0.6	0.5	1.0	-0.4	0.1	0.6
Medication: Bendroflumethiazide	0.7	1.1	3.0	-1.5	-1.7	-0.4	-0.5	-0.4	-0.9
Medication: Paracetamol	0.2	0.3	1.0	-0.7	-0.0	-0.0	0.7	-0.1	1.0
Medication: Lisinopril	1.2	1.5	2.7	0.7	-1.6	-1.2	-1.5	-0.1	-1.4
Medication: Atorvastatin	0.2	0.2	0.7	0.3	0.0	0.8	-0.7	-0.3	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.6	-0.0	0.3	-0.1	-1.3	-0.2	-1.0
Alcohol drinker status: Never	0.9	1.1	3.0	0.4	-0.5	1.0	1.3	1.7	-0.6
Ever smoked	1.4	2.5	4.4	1.9	-0.4	1.7	2.1	2.0	-0.4
Basal metabolic rate	0.3	1.6	5.6	-0.1	-2.4	-0.0	1.2	1.1	-1.1
Leg fat percentage (left)	0.3	1.2	4.0	-0.5	-2.0	-1.0	-0.4	-0.3	-1.2
Arm fat-free mass (left)	0.5	2.6	8.0	-0.1	-2.8	-0.4	1.7	1.1	-1.8
Number of operations (self-reported)	2.0	3.0	8.0	0.8	-2.7	-1.3	-0.0	0.7	-2.8
Average weekly beer plus cider intake	0.9	1.3	2.8	1.0	0.4	1.7	1.0	1.5	0.5
Irritability	1.1	1.8	4.7	2.2	-0.7	0.2	-0.9	1.2	-1.8
Risk taking	0.8	1.1	2.7	1.1	0.8	1.6	0.7	1.0	0.9
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.4	1.0	-1.8	-1.6	-0.6	-0.6	-1.3
Fractured/broken bones in last 5 years	2.0	2.5	4.5	1.7	-1.5	1.8	1.4	2.1	-0.7
Age started oral contraceptive pill	0.7	0.9	1.9	1.0	1.3	1.4	0.4	0.6	0.3
Diastolic blood pressure, automated reading	0.4	1.4	3.7	0.6	-1.9	-0.0	0.1	1.3	-1.6
Ever depressed for a whole week	0.2	0.3	0.9	-1.0	0.3	0.3	0.7	-0.3	0.2
Unable to work because of sickness or disability	3.3	4.3	9.5	-1.1	0.8	3.1	2.3	0.7	3.0
Commuting to job workplace: Cycle	1.0	1.2	2.7	-1.6	1.2	-1.1	-0.4	-1.2	0.6
Myopia	0.8	1.1	2.1	-0.3	-0.4	1.4	1.4	1.4	0.8
Vascular/heart problems diagnosed by doctor	0.4	1.1	4.6	0.9	0.7	0.5	0.7	0.4	2.2
Cholesterol lowering medication	0.3	0.4	1.7	0.3	0.0	0.2	-0.8	-0.3	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.1	-1.5	0.6	-0.7	-0.7	-1.4	0.7
Pain experienced in last month	0.3	0.5	1.6	0.8	0.2	0.1	1.3	0.3	0.7
Supplements: Calcium	0.3	0.3	0.7	0.3	0.4	0.8	0.7	0.6	0.3
Basal cell carcinoma (self-reported)	1.6	1.9	6.7	-1.1	-2.6	-0.9	-0.9	0.1	-1.4
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.4	0.5	-1.2	0.3	-0.0	0.9	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.2	-0.4	1.0	1.2	0.8	0.2	1.5
Heart disease (siblings)	0.8	1.0	3.2	0.2	-0.8	1.8	0.4	1.3	0.3
Alcohol drinker status: Previous	0.0	0.0	0.2	0.0	-0.2	0.1	0.1	0.5	0.2
Pack years of smoking	0.9	1.3	3.1	1.8	0.6	1.0	1.2	1.3	0.5
Impedance of whole body	0.5	2.6	9.2	0.7	3.0	0.5	-1.7	-1.0	1.3
Leg fat mass (left)	0.4	1.4	5.7	-0.5	-2.4	-1.0	0.1	0.0	-1.3
Arm predicted mass (left)	0.5	2.7	9.8	-0.5	-3.1	-0.6	1.3	0.8	-1.9