[Hub]/) : Traits : Breast Cancer : ← →

chr1:154,462,360-156,838,141

Best TWAS P=3.29e-11 · Best GWAS P=4.83e-11 conditioned to 0.894

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DAP3	0.03	0.01	blup	248	0.02	1.5e-03	-4.0	-5.2	2.3e-07	0.46	0.10	0.81	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FDPS	0.04	0.04	lasso	2	0.04	3.3e-05	-5.7	5.5	4.9e-08	-0.38	0.44	0.49	FALSE
3	CommonMind	Brain Pre-frontal Cortex	GBAP1	0.04	0.03	blup	337	0.03	8.6e-05	1.8	6.1	9.2e-10	-0.77	0.07	0.92	FALSE
4	CommonMind	Brain Pre-frontal Cortex	SCAMP3	0.05	0.04	lasso	2	0.03	3.9e-05	-5.2	5.2	1.9e-07	-0.45	0.59	0.23	FALSE
5	GTEx	Adipose Subcutaneous	GBAP1	0.10	0.10	lasso	3	0.08	6.1e-07	5.4	5.5	4.8e-08	-0.62	0.60	0.40	FALSE
6	GTEx	Adipose Subcutaneous	GBA	0.08	0.03	lasso	3	0.02	8.9e-03	5.4	5.5	4.8e-08	-0.58	0.24	0.14	FALSE
7	GTEx	Adipose Subcutaneous	SEMA4A	0.11	0.05	lasso	5	0.08	3.9e-07	-4.6	-5.5	3.2e-08	0.28	0.34	0.62	FALSE
8	GTEx	Adipose Visceral Omentum	GBAP1	0.07	0.11	enet	5	0.10	5.0e-06	5.4	5.5	5.1e-08	-0.63	0.41	0.46	FALSE
9	GTEx	Artery Aorta	GBAP1	0.31	0.36	enet	22	0.39	1.0e-22	5.4	5.7	1.2e-08	-0.73	0.62	0.37	FALSE
10	GTEx	Artery Tibial	RIT1	0.09	0.04	lasso	4	0.04	1.9e-04	-4.4	5.5	3.7e-08	-0.37	0.08	0.88	FALSE
11	GTEx	Artery Tibial	GBAP1	0.21	0.26	lasso	7	0.26	1.3e-20	5.3	5.6	1.7e-08	-0.72	0.73	0.27	FALSE
12	GTEx	Brain Cerebellar Hemisphere	MSTO1	0.21	0.00	enet	10	0.03	4.6e-02	-5.8	-5.9	4.0e-09	0.41	0.12	0.14	FALSE
13	GTEx	Brain Cerebellar Hemisphere	DAP3	0.13	0.12	lasso	2	0.13	2.8e-04	-5.8	-5.8	9.1e-09	0.42	0.04	0.79	FALSE
14	GTEx	Brain Cerebellum	HCN3	0.16	0.05	lasso	4	0.04	3.1e-02	-5.0	5.9	4.1e-09	-0.51	0.12	0.35	FALSE
15	GTEx	Brain Cerebellum	THBS3	0.17	0.15	enet	6	0.16	2.0e-05	4.7	-5.1	3.0e-07	0.78	0.34	0.33	FALSE
16	GTEx	Brain Cortex	GBAP1	0.25	0.14	enet	25	0.23	4.7e-07	5.4	-5.5	3.9e-08	0.60	0.45	0.41	FALSE
17	GTEx	Brain Frontal Cortex BA9	MTX1P1	0.20	0.05	enet	21	0.01	1.5e-01	-5.3	-5.5	3.5e-08	0.68	0.03	0.64	FALSE
18	GTEx	Breast Mammary Tissue	GBAP1	0.15	0.17	lasso	2	0.15	5.2e-08	5.3	5.4	8.0e-08	-0.66	0.65	0.34	FALSE
19	GTEx	Breast Mammary Tissue (Female)	FAM189B	0.05	-0.01	lasso	2	0.00	4.8e-01	-6.6	6.6	5.0e-11	-1.00	0.02	0.49	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	GBAP1	0.21	0.05	lasso	3	0.06	4.5e-03	5.4	5.8	7.5e-09	-0.56	0.34	0.33	FALSE
21	GTEx	Cells Transformed fibroblasts	HCN3	0.05	0.05	lasso	5	0.06	3.8e-05	-5.5	5.5	4.1e-08	-0.44	0.36	0.59	FALSE
22	GTEx	Cells Transformed fibroblasts	GBAP1	0.18	0.16	lasso	6	0.15	1.6e-11	5.4	5.7	9.5e-09	-0.67	0.72	0.28	FALSE
23	GTEx	Colon Sigmoid	GBAP1	0.16	0.13	enet	8	0.14	8.4e-06	5.3	6.0	2.2e-09	-0.79	0.05	0.93	FALSE
24	GTEx	Colon Transverse	GBAP1	0.13	0.15	lasso	5	0.11	6.4e-06	5.4	5.6	2.4e-08	-0.65	0.53	0.46	FALSE
25	GTEx	Colon Transverse	GBA	0.06	0.09	enet	8	0.08	7.9e-05	-4.6	5.3	1.1e-07	-0.53	0.52	0.22	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	GBAP1	0.22	0.19	enet	6	0.17	6.8e-07	5.4	5.8	5.1e-09	-0.67	0.29	0.68	FALSE
27	GTEx	Esophagus Mucosa	GBAP1	0.12	0.12	enet	22	0.09	1.7e-06	5.3	5.9	2.8e-09	-0.69	0.65	0.35	FALSE
28	GTEx	Esophagus Mucosa	THBS3	0.15	0.15	lasso	2	0.13	6.8e-09	5.4	-5.2	2.6e-07	0.66	0.72	0.28	FALSE
29	GTEx	Esophagus Mucosa	GBA	0.28	0.30	enet	26	0.34	4.2e-23	-4.7	5.9	4.7e-09	-0.56	0.88	0.12	FALSE
30	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	-6.1	-6.2	7.5e-10	0.86	0.03	0.97	FALSE
31	GTEx	Esophagus Mucosa	RP11-263K19.4	0.14	0.14	lasso	4	0.12	1.5e-08	5.4	-5.2	2.0e-07	0.66	0.71	0.29	FALSE
32	GTEx	Esophagus Muscularis	GBAP1	0.09	0.13	enet	4	0.12	8.9e-08	5.5	5.5	4.6e-08	-0.63	0.60	0.40	FALSE
33	GTEx	Heart Left Ventricle	GBAP1	0.18	0.22	enet	13	0.18	1.1e-09	5.5	5.5	3.2e-08	-0.61	0.59	0.41	FALSE
34	GTEx	Lung	GBAP1	0.16	0.16	lasso	5	0.15	1.6e-11	5.5	5.4	7.0e-08	-0.60	0.60	0.40	FALSE
35	GTEx	Lung	FAM189B	0.09	0.05	lasso	4	0.05	1.4e-04	-5.2	5.5	5.1e-08	-0.45	0.44	0.25	FALSE
36	GTEx	Lung	THBS3	0.11	0.07	lasso	4	0.04	1.0e-03	5.4	-5.2	2.0e-07	0.63	0.58	0.32	FALSE
37	GTEx	Lung	MSTO2P	0.07	0.01	enet	20	0.00	4.1e-01	-4.0	5.5	4.7e-08	-0.39	0.16	0.12	FALSE
38	GTEx	Muscle Skeletal	MSTO2P	0.07	0.05	lasso	2	0.05	1.1e-05	-5.7	5.8	8.2e-09	-0.43	0.27	0.67	FALSE
39	GTEx	Nerve Tibial	HCN3	0.17	0.28	lasso	6	0.25	5.8e-18	-5.5	5.6	2.1e-08	-0.45	0.43	0.57	FALSE
40	GTEx	Nerve Tibial	GBAP1	0.12	0.14	lasso	1	0.14	8.9e-10	5.3	5.3	1.1e-07	-0.66	0.69	0.31	FALSE
41	GTEx	Nerve Tibial	GBA	0.14	0.02	lasso	5	0.01	3.3e-02	5.4	5.6	1.9e-08	-0.61	0.39	0.16	FALSE
42	GTEx	Pancreas	GBAP1	0.12	0.17	enet	10	0.14	2.4e-06	5.5	5.2	2.6e-07	-0.59	0.46	0.44	FALSE
43	GTEx	Pancreas	GBA	0.12	0.05	enet	10	0.02	4.2e-02	5.4	6.0	2.6e-09	-0.71	0.15	0.56	FALSE
44	GTEx	Pancreas	MSTO2P	0.20	0.12	lasso	3	0.07	4.6e-04	-5.5	5.2	2.3e-07	-0.40	0.39	0.34	FALSE
45	GTEx	Prostate	GBAP1	0.47	0.30	lasso	7	0.32	1.1e-08	5.4	5.5	3.4e-08	-0.71	0.25	0.72	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	-6.0	6.1	9.1e-10	-0.82	0.02	0.97	FALSE
47	GTEx	Skin Sun Exposed Lower leg	RP11-263K19.4	0.04	0.01	enet	9	0.01	3.3e-02	5.3	-5.6	2.7e-08	0.65	0.23	0.34	FALSE
48	GTEx	Small Intestine Terminal Ileum	GBAP1	0.20	0.13	lasso	10	0.11	1.8e-03	-4.0	5.6	1.9e-08	-0.83	0.04	0.77	FALSE
49	GTEx	Spleen	FDPS	0.14	-0.01	enet	10	0.00	2.6e-01	-5.6	-5.6	2.7e-08	0.51	0.09	0.30	FALSE
50	GTEx	Spleen	GBAP1	0.33	0.23	enet	20	0.28	7.9e-08	5.4	6.1	9.8e-10	-0.77	0.06	0.93	FALSE
51	GTEx	Stomach	GBAP1	0.09	0.12	lasso	3	0.13	1.2e-06	5.5	6.2	5.6e-10	-0.58	0.32	0.65	FALSE
52	GTEx	Stomach	MTX1P1	0.22	-0.01	lasso	4	0.01	1.7e-01	-5.5	5.3	1.3e-07	-0.44	0.03	0.13	FALSE
53	GTEx	Testis	YY1AP1	0.54	0.34	lasso	7	0.38	4.7e-18	-5.6	5.9	3.7e-09	-0.43	0.19	0.81	FALSE
54	GTEx	Testis	THBS3	0.11	0.11	lasso	2	0.09	1.2e-04	5.5	-5.5	3.9e-08	0.61	0.30	0.49	FALSE
55	GTEx	Testis	RP11-263K19.4	0.08	0.12	lasso	2	0.10	2.4e-05	5.5	-5.5	4.4e-08	0.59	0.22	0.52	FALSE
56	GTEx	Testis	RP11-29H23.5	0.49	0.34	lasso	5	0.39	2.4e-18	-5.6	5.7	9.3e-09	-0.43	0.18	0.82	FALSE
57	GTEx	Thyroid	SYT11	0.09	0.00	enet	22	0.02	7.0e-03	2.0	5.2	2.0e-07	-0.27	0.05	0.23	FALSE
58	GTEx	Thyroid	HCN3	0.05	0.05	lasso	1	0.04	5.2e-04	-5.5	5.5	4.8e-08	-0.45	0.20	0.34	FALSE
59	GTEx	Thyroid	GBAP1	0.23	0.28	lasso	10	0.27	4.6e-21	4.7	5.2	1.9e-07	-0.67	0.74	0.26	FALSE
60	GTEx	Thyroid	FAM189B	0.08	0.10	lasso	2	0.11	5.3e-09	-5.2	5.6	2.6e-08	-0.45	0.44	0.56	FALSE
61	GTEx	Thyroid	GBA	0.24	0.04	enet	23	0.15	1.6e-11	-4.6	5.2	1.9e-07	-0.40	0.73	0.26	FALSE
62	GTEx	Vagina	GBAP1	0.27	0.08	lasso	7	0.17	1.3e-04	-5.3	6.3	2.5e-10	-0.80	0.06	0.75	FALSE
63	GTEx	Whole Blood	THBS3	0.17	0.20	enet	5	0.21	1.0e-18	5.3	-5.3	1.4e-07	0.64	0.72	0.28	FALSE
64	GTEx	Whole Blood	GBA	0.07	0.11	lasso	4	0.09	1.2e-08	-4.7	-5.5	5.1e-08	0.41	0.82	0.18	FALSE
65	GTEx	Whole Blood	RP11-263K19.4	0.15	0.17	lasso	4	0.17	9.5e-16	5.3	-5.3	8.8e-08	0.63	0.67	0.33	FALSE
66	METSIM	Adipose	SEMA4A	0.18	0.13	bslmm	363	0.13	1.8e-18	-4.6	-5.2	2.3e-07	0.30	0.27	0.72	FALSE
67	METSIM	Adipose	THBS3	0.09	0.10	lasso	7	0.12	4.7e-17	5.4	-5.9	3.1e-09	0.65	0.64	0.36	FALSE
68	NTR	Blood	SEMA4A	0.03	0.01	blup	364	0.02	7.5e-06	-3.9	-6.0	2.4e-09	0.28	0.73	0.07	FALSE
69	NTR	Blood	THBS3	0.03	0.02	blup	341	0.02	2.8e-08	4.7	-5.5	4.2e-08	0.65	0.81	0.18	FALSE
70	YFS	Blood	DAP3	0.02	0.03	lasso	5	0.03	4.4e-09	-4.4	5.1	3.1e-07	-0.38	0.18	0.82	FALSE
71	YFS	Blood	FAM189B	0.02	0.01	bslmm	312	0.02	3.2e-06	-4.0	-5.2	2.5e-07	0.66	0.14	0.86	FALSE
72	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	-6.1	-6.2	4.2e-10	0.89	0.01	0.67	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBA	0.03	0.00	blup	26	0.02	3.1e-04	-5.5	6.4	1.4e-10	-0.67	0.03	0.74	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBAP1	0.02	0.03	lasso	4	0.03	1.3e-07	5.4	6.0	2.6e-09	-0.65	0.46	0.51	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEMA4A	0.01	0.00	blup	51	0.01	1.2e-02	-1.5	-5.5	2.8e-08	0.21	0.00	0.17	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM46	0.03	0.01	blup	32	0.01	4.9e-03	-6.1	-5.2	1.8e-07	0.58	0.00	0.49	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	YY1AP1	0.03	0.01	enet	3	0.01	1.6e-03	-5.5	5.4	7.2e-08	-0.48	0.00	0.97	FALSE
78	The Cancer Genome Atlas	Colon Adenocarcinoma	HCN3	0.08	0.00	lasso	3	0.00	5.7e-01	-4.0	5.9	4.4e-09	-0.32	0.01	0.39	FALSE
79	The Cancer Genome Atlas	Esophageal Carcinoma	FAM189B	0.36	0.05	lasso	3	0.02	6.1e-02	5.3	5.3	1.1e-07	-0.65	0.00	0.21	FALSE
80	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MUC1	0.04	0.01	enet	4	0.02	1.3e-03	-6.1	-5.6	1.8e-08	0.64	0.02	0.48	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAG1AP1	0.07	0.00	blup	76	0.00	2.9e-01	-2.7	-6.6	4.4e-11	0.71	0.01	0.60	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GBA	0.04	0.01	blup	26	0.01	8.3e-03	-5.0	5.1	3.1e-07	-0.48	0.03	0.35	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HCN3	0.03	0.03	lasso	1	0.03	2.3e-04	-5.8	5.8	7.3e-09	-0.40	0.01	0.96	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	THBS3	0.02	0.03	lasso	4	0.03	2.1e-04	5.3	-5.6	2.5e-08	0.74	0.07	0.81	FALSE
85	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAP1	0.03	0.01	blup	26	0.02	1.9e-03	-4.0	5.7	9.5e-09	-0.86	0.01	0.95	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAG1AP1	0.07	0.05	blup	77	0.05	3.8e-06	-5.2	-6.0	1.4e-09	0.77	0.29	0.70	FALSE
87	The Cancer Genome Atlas	Lung Adenocarcinoma	GBAP1	0.02	0.03	enet	2	0.02	2.3e-03	5.3	5.4	8.3e-08	-0.66	0.04	0.27	FALSE
88	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GBA	0.02	0.00	blup	27	0.01	1.2e-02	-5.5	5.2	1.5e-07	-0.47	0.01	0.23	FALSE
89	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GBAP1	0.05	0.04	blup	26	0.04	1.6e-03	5.3	6.3	2.9e-10	-0.68	0.04	0.39	FALSE
90	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM46	0.08	0.08	lasso	2	0.07	2.1e-05	5.3	-5.3	1.1e-07	0.66	0.17	0.46	FALSE
91	The Cancer Genome Atlas	Prostate Adenocarcinoma	FDPS	0.02	0.02	lasso	2	0.01	1.6e-02	-5.7	5.7	9.8e-09	-0.45	0.01	0.72	FALSE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEMA4A	0.11	0.08	blup	51	0.08	7.1e-09	-4.6	-5.9	3.1e-09	0.31	0.02	0.95	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	GBAP1	0.02	0.01	blup	24	0.02	3.0e-03	5.3	6.6	3.3e-11	-0.81	0.01	0.54	TRUE
94	The Cancer Genome Atlas	Thyroid Carcinoma	SEMA4A	0.20	0.06	enet	17	0.07	2.5e-07	-4.6	-5.8	6.4e-09	0.19	0.02	0.95	TRUE