TWAS hub - IP6K2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.129	0.0670	1.5e-03	0.019	NA	0.045	NA	0.017	3.1e-02	NA	1.6e-03	NA	3.6e-02
2	GTEx	Artery Coronary	0.138	0.0720	1.2e-03	0.037	NA	0.059	NA	0.050	2.1e-02	NA	4.7e-03	NA	8.9e-03
3	GTEx	Artery Tibial	0.052	0.0303	2.5e-03	0.012	NA	0.018	NA	0.021	3.6e-02	NA	1.4e-02	NA	8.8e-03
4	GTEx	Cells Transformed fibroblasts	0.327	0.0990	2.6e-05	0.092	NA	0.110	NA	0.149	2.1e-07	NA	1.3e-08	NA	2.7e-11
5	GTEx	Nerve Tibial	0.115	0.0901	7.1e-03	0.042	NA	0.067	NA	0.052	6.1e-04	NA	1.8e-05	NA	1.4e-04
6	GTEx	Pancreas	0.078	0.0540	9.5e-03	0.004	NA	0.017	NA	0.013	2.2e-01	NA	6.3e-02	NA	9.0e-02
7	GTEx	Thyroid	0.267	0.1200	6.9e-03	0.105	NA	0.112	NA	0.115	2.0e-08	NA	7.2e-09	NA	4.5e-09
8	METSIM	Adipose	0.454	0.0679	5.0e-14	0.123	0.111	0.154	0.126	0.153	7.0e-18	3.1e-16	2.2e-22	2.1e-18	3.3e-22
9	YFS	Blood	0.194	0.0527	8.2e-07	0.018	0.036	0.046	0.045	0.047	8.9e-07	6.6e-12	8.8e-15	1.5e-14	3.1e-15
10	TCGA	Thyroid Carcinoma	0.149	0.0780	7.5e-03	0.010	0.002	0.020	NA	0.013	3.1e-02	1.9e-01	4.7e-03	NA	1.7e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Irritable Bowel Disease (IBD)	9.1	21.6	49.3	-5.7	-1.4	-6.9	-7.0	-5.9	0.4	-3.4	-4.9	-3.8	-0.9
Average weekly spirits intake	8.6	10.7	21.2	3.4	3.0	4.3	4.6	3.7	1.8	3.1	3.1	3.0	0.8
Qualifications: A levels/AS levels or equivalent	7.7	17.0	39.1	-4.4	-2.2	-3.6	-5.2	-6.2	-1.4	-1.3	-3.7	-4.6	-5.3
Pulse rate	6.9	11.6	23.1	3.4	4.2	1.9	2.9	3.6	3.7	3.2	2.7	3.0	4.8
Ulcerative Colitis (UC)	6.8	12.7	34.7	-4.4	-0.2	-5.9	-5.6	-3.5	1.3	-2.7	-3.6	-2.5	0.7
Qualifications: College or University degree	6.7	21.0	39.6	-6.1	-1.6	-5.2	-6.3	-6.2	-0.3	-1.3	-4.4	-4.8	-4.5
Crohns Disease (2017)	6.3	13.8	28.9	-4.8	-1.8	-4.8	-5.1	-5.4	-0.8	-2.2	-3.8	-3.0	-2.1
Pulse rate, automated reading	5.4	17.5	53.7	4.4	7.3	2.9	1.7	5.6	5.6	1.2	0.8	0.6	5.0
Crohns Disease (2012)	5.2	8.4	24.8	-5.0	-2.7	-4.1	-3.2	-3.9	-1.2	-1.2	-1.8	-1.2	-1.5
Trunk fat percentage	5.1	20.5	49.1	4.9	5.3	4.8	4.9	7.0	2.6	2.3	4.0	3.0	4.3
Fed-up feelings	5.0	9.1	20.2	2.3	-1.1	2.6	4.5	3.2	-0.6	2.3	4.4	4.0	2.5
Body fat percentage	4.9	19.3	49.9	4.7	4.1	4.3	5.1	7.1	1.3	1.8	4.3	3.6	4.7
Illnesses of siblings	4.7	6.6	18.4	1.8	4.3	3.1	2.5	1.4	3.5	3.3	1.2	1.3	0.4
Arm fat percentage (left)	4.5	17.9	50.0	4.4	3.8	4.1	4.9	7.1	0.4	1.4	4.1	3.6	4.7
Alcohol intake versus 10 years previously	4.4	6.6	12.0	2.5	1.3	2.4	3.1	3.5	2.3	1.7	3.0	2.5	2.8
Ulcerative Colitis	4.2	6.1	20.8	-3.4	-0.9	-4.6	-3.5	-3.2	0.7	-1.0	-1.7	-1.0	0.2
Loneliness, isolation	4.2	5.8	15.9	0.3	-1.6	0.6	3.3	2.1	-0.3	2.2	4.0	3.8	2.2
Number of full sisters	4.1	5.0	15.8	-1.7	-4.0	-3.0	-1.2	-1.6	-3.6	-1.9	0.1	0.8	1.0
Arm fat percentage (right)	3.9	15.3	43.2	4.1	3.0	3.6	4.6	6.6	-0.1	1.1	4.0	3.6	4.6
Leg fat percentage (left)	3.9	14.2	38.8	3.5	1.3	2.5	4.5	6.2	-1.0	0.7	4.3	4.3	4.9
Intelligence (Savage-Jansen 2018)	3.8	11.6	26.1	-4.9	-2.0	-4.5	-4.5	-5.1	0.8	-0.3	-2.7	-2.6	-2.6
Father’s age at death	3.8	5.1	9.7	-2.3	0.8	-2.6	-3.1	-2.8	2.5	-1.2	-2.5	-2.1	-1.4
Medication: Seretide 50 evohaler	3.8	4.4	11.4	2.1	1.2	2.0	2.6	3.4	0.6	1.1	2.8	1.9	1.8
Miserableness	3.7	6.3	16.5	0.8	-2.2	1.4	3.5	2.7	-1.5	1.3	4.1	3.5	2.0
Relative age voice broke	3.6	5.4	10.4	-0.6	-1.9	-0.8	-2.5	-3.0	-1.5	-2.4	-3.1	-3.2	-2.5
Hypothyroidism/myxoedema (self-reported)	3.6	7.0	14.7	-3.0	-3.8	-2.9	-2.4	-2.2	-3.8	-2.5	-1.3	-1.5	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.6	4.2	14.4	-1.0	-0.6	-1.4	1.7	1.7	-0.6	1.4	2.9	3.8	2.8
Number of live births	3.5	4.9	9.5	2.4	1.4	2.5	3.1	1.9	1.4	2.4	2.7	2.4	1.2
Leg fat percentage (right)	3.5	12.6	34.0	3.7	1.3	2.7	4.3	5.8	-1.2	0.5	3.9	3.8	4.5
Whole body fat mass	3.5	14.6	38.9	4.2	3.8	3.8	4.1	6.2	1.7	0.8	3.3	2.6	4.7
Trunk fat mass	3.4	14.8	38.1	4.2	4.7	4.1	3.8	6.2	2.6	1.0	3.0	2.1	4.3
Serious illness, injury or assault of a close relative in last 2 years	3.4	3.9	7.2	-2.0	-2.0	-1.2	-2.1	-2.3	-1.4	-1.8	-2.0	-2.1	-2.7
Mood swings	3.4	6.1	16.9	-0.1	-2.3	-0.2	2.5	2.9	-0.8	0.5	4.1	3.5	3.2
Medication: Paracetamol	3.4	5.3	14.4	1.8	-1.3	2.5	3.8	1.2	0.4	2.5	3.2	3.0	-0.2
Leg fat mass (left)	3.4	13.2	37.3	3.6	2.3	3.1	4.2	6.1	0.2	0.4	3.7	3.4	5.0
Depressed Affect (Nagel 2018)	3.3	7.0	21.1	-0.6	-2.2	0.9	3.5	2.7	-0.7	1.8	4.6	3.8	2.1
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.4	24.8	-0.8	-5.0	-1.6	-1.3	-3.1	-2.4	-2.2	-1.4	-0.7	-1.2
Qualifications: nursing, teaching	3.3	5.1	12.3	-2.7	-0.6	-1.0	-2.5	-2.8	-1.4	-0.6	-1.9	-3.1	-3.5
Medication for pain relief, constipation, heartburn	3.2	5.5	16.4	-1.1	1.9	0.3	-2.7	-1.4	-0.0	-1.4	-3.4	-4.0	-3.4
Mouth/teeth dental problems: Dentures	3.1	5.2	10.6	2.7	0.6	1.7	3.0	3.3	0.5	0.9	2.4	2.8	2.7
Leg fat mass (right)	3.1	12.0	33.1	3.7	2.3	3.1	3.9	5.8	0.1	0.2	3.3	3.0	4.7
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.8	15.5	1.8	2.1	1.2	1.6	3.9	1.1	0.2	1.5	1.5	2.3
Qualifications: O levels/GCSEs or equivalent	3.0	4.8	9.8	-1.9	-0.5	-1.5	-3.1	-2.7	0.5	-0.9	-2.4	-3.1	-2.9
Prostate Cancer	2.9	4.1	10.3	1.7	-2.2	0.9	2.7	2.1	-0.8	1.3	3.2	2.7	0.3
Medication: Levothyroxine sodium	2.9	4.8	11.6	-2.3	-3.2	-2.4	-2.1	-1.5	-3.4	-2.5	-1.0	-1.2	-0.6
Exposure to tobacco smoke at home	2.9	3.2	11.2	0.7	-1.2	-0.1	1.5	2.6	-1.0	-0.2	2.0	2.2	3.4
Illnesses of siblings: Diabetes	2.9	3.5	11.0	-2.4	-2.0	-2.3	-1.9	0.1	-2.0	-3.3	-0.6	-1.1	0.5
Smoking status: Previous	2.9	4.4	11.1	0.8	-0.2	0.5	2.6	0.4	2.7	3.2	2.4	3.3	1.4
Osteoporosis (self-reported)	2.9	3.5	15.4	-1.0	-1.4	0.4	-1.1	-1.4	-2.1	-1.0	-1.6	-2.4	-3.9
Arm fat mass (left)	2.9	11.9	34.5	3.6	3.3	3.5	3.8	5.9	0.6	0.4	3.0	2.5	4.3
Irritability	2.9	4.9	18.2	-2.2	-4.3	-2.2	0.5	-0.9	-2.9	-0.4	1.9	2.2	1.6
Hayfever, allergic rhinitis or eczema	2.8	6.1	21.8	-1.6	1.4	1.2	-2.0	-1.6	0.2	-1.3	-2.8	-4.1	-4.7
Arm fat mass (right)	2.8	11.3	32.6	3.7	2.8	3.3	3.7	5.7	0.3	0.3	3.0	2.6	4.3
Ever had bowel cancer screening	2.7	3.2	11.0	-2.1	-2.0	-2.1	-1.5	-3.3	-0.5	-0.3	-1.3	-0.7	-1.7
Age at First Birth	2.6	3.8	9.2	-0.6	1.6	-0.1	-2.0	-2.5	1.2	0.6	-2.5	-2.9	-3.0
Blood Eosinophil Count	2.6	20.1	69.3	3.1	7.8	2.5	-2.6	1.4	8.3	-1.7	-4.1	-5.1	1.2
Hypothyroidism (self reported)	2.6	5.9	18.6	-3.1	-3.9	-2.8	-1.5	-0.9	-4.3	-2.0	0.1	-0.2	-0.2
Angina	2.6	3.4	6.8	2.5	1.0	0.9	2.0	1.8	0.7	1.5	1.6	2.4	2.6
Body mass index (BMI)	2.6	11.1	31.0	3.0	0.8	2.2	3.8	5.6	-2.2	-0.5	3.4	3.6	4.8
Qualifications: None of the above	2.6	5.6	11.1	1.8	-1.4	1.4	3.1	2.4	-1.9	0.2	2.8	3.3	3.2
Prospective memory result	2.6	3.2	7.2	2.5	1.5	2.3	2.2	2.7	-0.2	0.7	1.4	1.2	1.5
Age at first live birth	2.6	4.6	8.6	-1.9	2.7	-0.0	-1.9	-1.5	2.9	1.1	-1.7	-2.9	-2.9
Pack years adult smoking proportion	2.5	3.8	13.4	-0.2	-3.3	-0.6	1.4	0.9	-3.7	-0.4	2.0	2.3	0.9
Townsend deprivation index at recruitment	2.5	3.5	8.6	0.2	-2.9	-0.7	1.4	0.6	-2.9	0.3	1.9	2.8	2.0
Impedance of arm (left)	2.5	11.7	43.7	2.0	6.4	3.0	0.6	0.8	6.6	3.6	-0.3	-1.4	-1.4
Medication: Paracetamol	2.5	4.2	10.8	1.5	-1.8	1.8	3.3	1.0	0.3	2.0	3.0	2.9	0.4
Hypertension (Self-reported)	2.5	6.9	21.3	-2.3	-3.8	-4.6	-2.9	-0.9	-2.3	-3.1	-1.1	-0.1	1.7
Average weekly beer plus cider intake	2.5	3.7	10.3	1.9	1.5	2.8	2.2	3.2	1.2	0.3	1.6	1.1	1.7
Heel T-Score	2.4	19.5	82.8	2.9	9.1	4.2	1.8	7.6	3.5	0.6	0.5	-0.5	3.4
BMI	2.4	14.0	40.4	3.3	2.3	3.4	4.6	6.4	-1.9	0.5	3.7	3.6	4.5
High blood pressure (mother)	2.4	3.3	8.3	-1.7	-1.9	-2.9	-2.5	-1.7	-1.8	-1.7	-1.3	-1.2	0.1
Past tobacco smoking	2.4	4.4	12.5	-0.8	1.2	-0.7	-2.9	0.1	-2.0	-3.0	-2.5	-3.5	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.5	20.2	0.9	4.5	1.0	0.5	4.3	2.1	-0.1	0.3	0.1	3.0
Hair/balding pattern: Pattern 4	2.4	5.9	14.2	0.7	0.5	1.9	3.6	2.2	1.0	3.0	3.8	3.4	1.1
Angina (self-reported)	2.4	3.2	7.7	2.5	0.8	0.6	1.9	1.7	0.4	1.3	1.5	2.5	2.8
Pack years of smoking	2.4	3.5	11.8	-0.6	-3.4	-1.3	0.9	0.6	-3.3	-0.5	1.8	2.2	1.1
Verbal and Numeric Reasoning (VNR)	2.3	5.6	13.3	-3.6	-1.5	-2.1	-2.5	-3.7	0.3	0.4	-1.3	-1.9	-3.5
Waist Hip Ratio (WHR)	2.3	10.3	37.6	0.5	4.8	-1.2	-3.4	-1.6	6.1	-1.7	-3.2	-3.3	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	6.2	1.5	-0.6	1.1	2.1	2.5	0.5	0.7	2.3	2.1	2.4
Serious illness, injury or assault to yourself	2.3	2.7	4.0	-1.0	-2.0	-1.8	-2.0	-1.7	-1.2	-1.7	-1.9	-1.5	-1.5
Had other major operations	2.3	2.8	5.0	-1.5	-1.9	-0.7	-1.5	-2.2	-1.6	-1.7	-1.7	-1.6	-2.0
Heart attack	2.3	2.9	14.3	0.4	-1.4	-1.6	0.1	1.7	-1.4	-1.4	1.0	1.6	3.8
Coronary Artery Disease (CAD)	2.2	2.7	6.7	2.6	0.9	1.2	1.6	2.2	1.3	1.0	1.1	1.4	2.1
Height	2.2	43.1	185.0	1.2	8.3	1.5	-5.3	-4.5	13.6	-1.0	-7.4	-8.2	-1.6
High blood pressure	2.1	5.9	17.5	-2.1	-3.5	-4.2	-2.8	-0.9	-1.9	-3.0	-1.2	-0.3	1.4
Number of full brothers	2.1	2.6	11.8	0.0	-3.4	-0.5	0.8	-0.5	-2.9	-0.4	1.6	1.4	0.7
Illnesses of father: High blood pressure	2.1	2.6	9.4	-2.0	-0.8	-3.1	-2.4	-0.1	0.7	-1.8	-1.0	-0.8	0.7
Age started oral contraceptive pill	2.1	2.6	7.0	-0.5	0.7	0.3	-1.1	-2.6	1.7	1.1	-1.4	-2.0	-2.6
Heart attack/myocardial infarction (self-reported)	2.1	2.8	13.9	0.6	-1.2	-1.3	0.3	1.7	-1.3	-1.1	1.2	1.7	3.7
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	7.7	-1.1	-2.8	-2.2	-1.7	-2.6	-0.3	-0.6	-1.0	-0.5	-1.0
Medication for hormone replacement therapy	2.0	2.2	6.5	1.2	1.1	1.0	-1.2	-1.1	0.6	-1.6	-2.2	-2.5	-1.3
High blood pressure (siblings)	2.0	2.9	4.8	-1.1	-1.9	-1.2	-2.0	-1.1	-2.2	-2.2	-1.6	-1.9	-1.3
Age at last live birth	2.0	2.9	6.1	-1.8	1.8	-0.2	-1.7	-1.9	1.3	0.9	-1.4	-2.5	-2.2
Ever smoked	2.0	3.5	10.0	0.3	-1.2	1.0	2.8	-0.2	1.5	2.6	2.3	3.2	0.5
Major Depression (MDD)	1.9	2.3	6.0	-0.5	-2.4	-0.4	1.5	0.8	-1.0	0.9	2.4	2.4	0.8
Diabetes (self-reported)	1.9	3.0	13.3	0.2	1.3	-2.1	-1.4	1.7	0.9	-2.2	-0.1	0.1	3.6
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	7.3	-1.1	-0.1	0.1	-1.7	-1.6	-0.2	-1.7	-2.1	-2.7	-2.0
Impedance of arm (right)	1.9	8.7	33.3	1.7	5.4	2.5	0.3	0.2	5.8	3.2	-0.6	-1.5	-1.8
Overall health rating	1.9	4.1	7.4	2.7	-1.4	1.6	2.6	2.3	-0.0	0.1	2.3	2.4	2.5
Diabetes diagnosed by doctor	1.9	3.1	13.0	-0.7	1.3	-2.2	-1.4	2.0	1.1	-2.0	0.1	0.2	3.6
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	9.3	-3.0	-0.0	-1.7	-2.1	-2.1	0.5	-1.2	-1.7	-1.5	-1.7
Financial situation satisfaction	1.9	2.4	4.7	-0.4	-1.2	-0.4	1.3	2.0	-1.4	-0.3	2.2	2.1	2.1
Bipolar Disorder (2011)	1.8	1.8	4.9	-1.6	-2.2	-2.2	-1.6	-1.2	-1.1	0.0	-0.5	-0.4	0.0
Cardiovascular Disease	1.8	6.0	15.1	-1.2	-3.4	-3.9	-1.6	1.4	-2.6	-2.7	0.5	1.2	3.5
Allergy	1.8	4.2	11.3	1.5	-1.6	-1.1	1.5	1.2	-2.0	1.2	2.2	3.3	3.4
Medication: Ramipril	1.8	2.3	5.5	-1.4	-1.9	-2.1	-1.2	-0.2	-2.3	-2.1	-0.4	0.2	1.2
Fluid intelligence score	1.8	3.8	10.9	-3.3	-2.3	-1.8	-1.4	-2.8	-0.4	0.9	-0.1	-0.7	-2.6
Standing height	1.8	18.0	76.6	-0.3	5.0	0.8	-3.8	-2.7	8.8	-0.8	-4.4	-5.8	-1.3
Guilty feelings	1.8	2.8	5.7	1.8	-0.2	1.7	2.4	1.1	1.0	1.3	2.0	2.1	1.9
Ever depressed for a whole week	1.8	2.2	8.6	-0.9	-2.9	-1.2	-0.7	-1.9	-2.0	-1.1	-0.5	-0.3	-1.3
Relative age of first facial hair	1.7	3.5	6.0	-1.2	-1.8	-0.9	-1.9	-2.4	-0.3	-1.9	-2.3	-2.4	-2.4
Number of incorrect matches in round	1.7	2.8	6.2	0.8	-0.7	2.0	2.5	0.8	-2.4	2.0	1.9	1.6	-0.8
Financial difficulties in last 2 years	1.7	2.2	6.4	0.9	-1.1	-0.2	1.5	1.3	-1.0	0.3	2.0	2.2	2.5
Wheeze or whistling in the chest in last year	1.7	3.1	8.0	1.9	2.8	2.8	1.7	1.8	2.0	0.5	0.7	-0.1	0.6
Illnesses of father: Heart disease	1.7	2.4	4.7	-0.3	-1.3	-1.2	-1.8	-1.4	-2.0	-1.8	-2.2	-1.6	-1.3
Back pain experienced in last month	1.7	2.5	5.6	0.3	0.1	1.3	2.4	1.8	1.4	1.1	1.9	2.3	1.5
Vascular/heart problems diagnosed by doctor	1.7	4.6	13.2	1.1	3.5	3.6	1.5	-0.3	2.1	2.2	0.0	-0.9	-2.7
Heart disease (siblings)	1.7	2.1	6.9	0.5	-2.6	-0.8	1.1	0.1	-1.6	0.8	2.0	2.0	1.0
Lupus	1.6	2.4	5.8	-1.2	-1.2	-2.2	-1.9	-1.1	0.8	-2.4	-1.1	-0.8	1.7
Supplements: Zinc	1.6	1.8	3.9	-0.7	-1.7	-1.7	-1.6	-2.0	-0.8	-1.0	-1.1	-0.9	-1.2
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	7.5	-1.6	-2.7	-1.0	-0.7	-1.2	-1.8	-1.4	-0.2	-0.4	-0.8
Medication: Cholesterol lowering	1.6	2.4	12.1	0.7	1.2	-0.6	0.5	2.4	1.0	0.1	0.9	1.6	3.5
Tense / ‘highly strung’	1.6	2.6	9.2	-1.2	-2.4	-0.6	-1.1	-1.2	-3.0	-1.7	-0.9	-1.2	-1.3
Birth weight of first child	1.6	3.0	7.5	0.7	0.5	-0.2	-1.8	-2.7	1.8	-1.3	-2.6	-2.2	-1.2
Peak expiratory flow (PEF)	1.6	3.7	12.8	-2.1	-2.7	-3.6	-2.1	-2.0	0.2	-1.4	-0.5	0.0	1.1
Commuting to job workplace: Public transport	1.6	1.8	6.6	0.9	0.6	1.9	0.3	-0.8	1.5	1.6	-0.4	-1.2	-2.6
Impedance of whole body	1.6	8.1	34.0	1.6	5.1	2.1	0.6	0.8	5.8	3.4	0.2	-0.7	-0.7
Breast Cancer	1.5	3.7	9.7	-1.0	-0.3	-2.2	-3.1	-1.0	-0.9	-2.8	-2.2	-2.4	-0.7
Fasting Glucose	1.5	1.8	5.5	0.6	0.4	1.4	1.6	2.3	-1.5	1.0	1.2	1.1	1.1
Systolic Blood Pressure	1.5	7.5	16.6	-1.2	-4.1	-4.1	-1.6	2.1	-2.9	-3.1	0.9	1.4	3.6
Neuroticism	1.5	3.7	11.1	-1.2	-2.7	-0.1	1.7	1.4	-1.9	0.4	3.3	2.3	1.8
Systolic blood pressure, automated reading	1.5	4.3	13.1	-0.2	-3.6	-2.6	-0.2	1.2	-2.4	-1.8	0.9	2.0	2.7
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	13.7	0.5	3.5	1.0	0.3	3.7	1.6	-0.2	0.5	-0.2	2.0
Length of working week for main job	1.5	1.6	8.8	-0.1	-1.0	-0.6	0.6	0.1	-3.0	-0.0	1.2	1.5	1.3
Gout (self-reported)	1.5	2.0	8.2	2.9	1.0	0.9	1.0	1.8	0.9	0.4	0.8	0.8	2.0
Health satisfaction	1.5	2.0	6.4	0.9	-0.4	0.7	1.7	2.5	0.0	0.2	1.8	1.9	1.7
Eye problems/disorders: None of the above	1.5	1.7	4.5	0.1	0.8	0.7	-1.1	-1.6	0.1	-0.6	-1.8	-2.1	-2.0
Eye problems/disorders: Cataract	1.5	1.8	4.7	-1.0	-1.6	-1.6	0.4	0.8	-0.0	0.0	1.5	2.0	2.2
Illnesses of father: None of the above (group 1)	1.5	1.8	2.6	0.6	1.4	1.4	1.6	1.0	1.4	1.6	1.6	1.3	1.2
Ever had prostate specific antigen (PSA) test	1.5	1.7	5.6	0.6	2.2	1.0	1.0	0.7	2.4	1.7	0.9	0.5	-0.1
Bipolar Disorder or Schizophrenia	1.4	3.4	11.6	-1.9	-3.4	-2.8	-1.6	-0.6	-2.1	-1.9	0.4	0.0	0.7
Schizophrenia (2018)	1.4	2.9	9.8	-1.6	-3.1	-2.8	-0.8	-0.4	-2.0	-0.9	1.1	1.1	1.2
Allergy or Eczema	1.4	3.6	12.0	-2.1	1.1	0.2	-1.7	-1.4	0.6	-0.9	-2.0	-2.9	-3.5
Severe depression (siblings)	1.4	1.6	3.0	1.0	-1.6	-0.4	-1.0	-1.7	-0.9	-1.0	-1.4	-1.3	-1.6
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.1	0.8	0.9	1.3	1.8	1.7	0.2	1.0	1.5	1.3	1.2
Neuroticism score	1.4	2.9	7.7	-0.4	-1.9	-0.1	1.5	1.3	-1.3	0.1	2.8	2.2	2.6
Forced expiratory volume in 1-second (FEV1)	1.4	4.7	10.8	-2.1	0.7	-2.1	-3.3	-2.6	2.2	-1.0	-2.7	-2.7	-0.6
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	6.1	-2.5	-1.3	-1.3	-1.4	-1.9	0.3	-0.8	-0.9	-0.8	-0.7
Forced vital capacity (FVC), Best measure	1.4	5.3	12.1	-1.2	1.6	-0.9	-3.1	-2.7	2.4	-0.9	-3.3	-3.5	-1.5
Medication: Allopurinol	1.4	1.8	5.2	2.3	1.1	1.1	1.0	2.0	1.4	0.7	1.0	0.6	1.3
Medication: Aspirin	1.4	1.8	8.3	0.6	-0.8	-2.4	-0.8	0.2	-0.8	-0.9	-0.3	1.0	2.9
Neuroticism (2016)	1.3	1.8	4.7	1.3	-0.3	0.9	1.4	2.2	-0.4	-0.5	1.6	1.2	2.1
Type 2 Diabetes (T2D) (2018)	1.3	2.5	10.2	-0.1	0.4	-2.0	-1.4	1.8	0.6	-2.2	-0.1	-0.1	3.2
Multivitamins +/- minerals	1.3	1.6	3.3	1.3	-1.8	0.8	1.7	-0.5	0.2	1.7	1.5	1.6	-0.0
Sitting height	1.3	9.2	41.4	0.6	5.7	2.9	0.6	1.3	6.4	2.2	0.2	-1.4	1.0
Pain all over the body in last month	1.3	1.4	6.0	0.6	-2.5	-0.1	-0.3	-0.7	-2.2	-1.4	-0.1	-0.5	-0.6
Happiness	1.3	1.6	7.7	-1.3	-2.8	-1.6	0.1	-0.1	-0.9	0.3	1.3	1.2	0.0
Lung cancer (father)	1.3	1.6	3.3	0.1	-1.2	0.2	1.4	1.7	-0.7	-0.2	1.8	1.8	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	9.4	-1.1	0.9	-1.6	-3.1	-2.6	1.9	-0.8	-2.8	-2.8	-0.7
Pulse wave Arterial Stiffness index	1.3	1.6	3.8	1.7	1.9	1.2	0.4	1.7	1.8	-0.5	-0.2	-0.1	1.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	8.3	-1.3	-1.1	0.2	-0.1	-2.8	-0.3	0.9	-0.3	-0.7	-2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	4.6	-0.8	-1.4	-1.0	0.5	0.8	-0.9	-0.9	1.4	1.5	2.1
Eye problems/disorders: Glaucoma	1.3	1.5	4.3	-0.7	-1.2	-1.9	-0.2	0.1	-1.6	-0.3	0.9	1.4	2.1
Medication: Blood pressure	1.3	2.5	10.3	-1.8	-2.0	-3.2	-1.2	0.4	-1.3	-1.1	0.2	1.2	1.4
Hand grip strength (left)	1.2	3.1	7.9	2.0	2.5	2.8	1.4	1.1	2.2	1.8	0.0	-0.5	-1.3
Sensitivity / hurt feelings	1.2	2.1	4.7	-1.6	-0.1	-1.9	-2.1	-1.5	0.3	-2.2	-1.1	-1.0	1.0
Medication: Co-codamol	1.2	1.4	5.0	1.2	-1.4	0.7	1.0	1.3	-2.2	-0.8	0.4	0.7	0.9
Weight	1.2	5.9	16.2	2.6	2.8	2.3	1.8	4.0	1.6	-0.9	1.1	0.7	3.8
Falls in the last year	1.2	1.6	4.2	-0.1	-0.3	-0.9	-1.6	-1.7	-0.5	-1.9	-2.0	-1.4	-0.3
Breastfed as a baby	1.2	1.5	3.3	1.0	1.4	1.6	-0.1	-0.7	1.3	0.6	-1.1	-1.5	-1.8
Pulse wave peak to peak time	1.2	1.4	3.4	-1.9	-1.6	-1.2	-0.6	-1.6	-1.3	0.4	0.1	-0.2	-1.0
Neck or shoulder pain in last month	1.2	1.8	4.7	0.8	-1.9	0.3	1.7	0.7	0.0	0.3	1.7	2.2	1.5
Comparative height size at age 10	1.2	6.7	20.1	-0.6	3.2	1.0	-2.7	-2.4	2.6	-0.8	-3.4	-4.5	-2.0
Had major operations	1.2	1.4	5.8	-0.2	-2.4	-0.5	0.6	0.7	-1.1	-0.6	1.4	1.0	1.7
Medication: Aspirin	1.2	1.6	8.4	0.5	-0.6	-2.2	-0.4	0.4	-0.1	-0.4	0.2	1.4	2.9
Myopia	1.2	1.8	10.5	-1.2	-0.1	0.9	-0.1	-1.1	0.2	1.4	-0.6	-1.2	-3.2
Schizophrenia (2014)	1.1	2.5	8.7	-1.4	-3.0	-2.3	-0.8	-0.7	-2.2	-0.8	0.7	0.9	0.9
Smoking Status	1.1	2.7	9.7	0.9	-3.1	0.1	2.0	-0.1	-1.0	0.1	1.9	2.6	1.1
Number of treatments/medications taken	1.1	2.1	7.1	2.0	-0.4	0.5	1.1	2.7	-0.2	-1.1	1.0	1.1	2.1
Hand grip strength (right)	1.1	2.9	7.1	2.3	2.3	2.6	1.0	1.1	2.7	1.0	-0.2	-0.8	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	8.7	0.6	-3.0	0.0	0.7	0.3	-2.3	-0.7	1.0	0.8	0.5
Hair/balding pattern: Pattern 2	1.1	1.3	3.2	-0.8	-0.3	-0.9	-1.6	-1.0	-0.5	-1.8	-1.7	-1.4	-0.1
Had menopause	1.1	1.4	3.2	-1.5	0.2	-1.3	-1.5	-1.8	-0.4	-0.4	-1.2	-1.0	-1.2
Forced vital capacity (FVC)	1.1	4.3	8.8	-1.7	1.2	-1.1	-2.9	-2.5	2.2	-0.7	-2.8	-3.0	-1.3
Glaucoma (self-reported)	1.1	1.3	4.3	-1.2	-1.2	-2.1	-0.5	-0.0	-1.1	-0.1	0.6	1.1	1.7
Worry too long after embarrassment	1.1	1.8	4.2	-1.6	0.8	-1.3	-2.0	-0.8	0.7	-1.7	-1.3	-1.4	1.2
Mother’s age at death	1.1	1.4	3.9	0.5	1.5	1.0	-0.5	-0.1	2.0	0.7	-0.6	-1.5	-1.8
Alcohol drinker status: Never	1.1	1.3	2.7	-0.4	1.0	-1.0	-1.6	-0.1	-1.4	-1.6	-1.5	-1.2	0.5
Fractured/broken bones in last 5 years	1.1	1.5	3.5	-1.1	-1.6	-1.9	-1.4	-1.2	-0.7	-1.6	-0.9	-0.5	0.2
Pain experienced in last month	1.1	1.9	3.5	-1.2	1.4	-1.0	-1.9	-1.3	0.0	0.1	-1.6	-1.9	-1.7
Neuroticism (Nagel 2018)	1.0	2.3	6.0	-1.9	-2.4	-0.3	1.0	0.9	-1.6	0.1	2.4	1.4	0.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.4	0.7	-1.7	0.8	0.6	-1.4	-1.3	0.4	0.1	-0.2	-1.8
Medication: Atenolol	1.0	1.2	5.4	2.3	-0.5	0.9	1.1	1.3	-0.1	0.4	0.9	0.9	1.1
Medication: Amlodipine	1.0	1.4	3.7	0.0	-0.1	-1.2	0.5	1.5	-0.4	0.5	1.5	1.9	1.8
Emphysema/chronic bronchitis	1.0	1.1	4.3	0.6	0.1	0.2	1.5	0.2	0.8	0.5	1.4	2.1	1.0
Medication: Ibuprofen	1.0	1.2	3.1	-0.8	-0.7	-0.6	0.7	1.4	-0.5	-0.6	1.3	1.7	1.8
Supplements: Vitamin C	1.0	1.2	2.4	1.3	1.2	1.5	0.6	-1.3	0.6	1.3	-0.2	-0.6	-1.4
Mineral and other dietary supplements	1.0	1.4	3.4	-0.4	1.0	0.6	1.3	1.6	0.3	1.4	1.8	1.3	0.7
Breast cancer (self-reported)	1.0	1.3	3.0	1.4	1.0	1.6	1.2	0.5	1.7	1.2	0.7	0.7	0.2
Number of self-reported non-cancer illnesses	1.0	1.7	5.5	-0.4	-2.3	-1.3	-1.4	-1.0	-0.6	-2.0	-1.0	-1.0	-0.4
Wears glasses or contact lenses	1.0	1.2	3.4	-0.6	1.0	0.4	0.7	1.8	1.6	0.7	1.5	0.7	0.8
Medication: Lisinopril	1.0	1.2	2.7	-0.0	-1.2	-1.5	-1.6	-0.8	-0.6	-1.5	-1.3	-1.0	-0.1
Medication: Atorvastatin	1.0	1.2	3.3	-0.5	-0.1	-1.0	0.6	1.3	0.2	0.6	1.5	1.7	1.8
Unable to work because of sickness or disability	1.0	1.3	4.0	0.3	-2.0	-0.5	-0.5	-1.5	-1.5	-0.9	-1.0	-0.3	-1.4
Commuting to job workplace: Cycle	1.0	1.3	4.6	-0.3	2.1	0.8	0.2	0.6	2.1	1.2	0.3	-0.6	-0.7
Ever had hysterectomy (womb removed)	0.9	1.1	3.3	0.0	0.9	1.5	-0.2	0.0	0.2	-0.5	-1.3	-1.5	-1.8
Vitamin and mineral supplements	0.9	1.2	4.8	-0.3	1.8	-0.3	-0.5	2.2	0.7	-0.9	-0.2	-0.1	1.4
Medication: Metformin	0.9	1.3	6.7	-0.6	1.3	-1.3	-0.8	0.7	0.6	-0.9	0.0	-0.0	2.6
Diabetes (mother)	0.9	1.2	6.0	0.8	0.6	-0.2	-0.3	1.7	-0.4	-1.2	0.1	-0.1	2.5
Waist circumference	0.9	3.4	12.0	2.0	2.5	0.7	0.6	2.8	1.2	-1.4	0.4	0.4	3.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	4.0	-0.7	-0.8	-0.5	0.5	1.3	-0.4	-0.7	1.2	1.4	2.0
Illnesses of mother	0.9	1.1	4.9	-0.2	0.1	1.6	0.9	-0.8	-0.3	1.2	-0.0	-0.3	-2.2
Migraine (self-reported)	0.9	1.2	4.0	0.1	-0.8	-1.6	-0.9	-1.1	2.0	-0.9	-0.1	0.3	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.7	-0.8	0.5	-0.0	-1.7	-1.8	1.6	-0.7	-1.5	-2.2	-1.3
Friendships satisfaction	0.9	1.1	6.5	-2.5	-0.6	-0.2	0.4	0.8	-0.3	0.9	0.8	0.5	-1.2
Medication: Bendroflumethiazide	0.9	1.4	3.5	-1.9	-0.5	-1.7	-1.4	0.0	-1.3	-1.5	-0.7	-0.5	-0.2
Diastolic blood pressure, automated reading	0.9	2.8	7.2	0.9	-2.1	-0.9	0.3	2.7	-2.1	-1.5	1.2	1.2	2.3
Supplements: Calcium	0.9	1.0	3.4	-0.9	-0.7	-0.1	-0.4	-1.8	-0.3	0.3	-1.0	-0.6	-1.8
Bipolar Disorder (2018)	0.8	1.3	3.3	-1.0	-1.6	-1.0	-1.5	-0.4	-0.8	-1.8	-0.6	-1.3	-0.4
Depression (Nagel 2018)	0.8	1.1	2.7	-0.7	-1.5	-0.4	0.8	1.2	0.1	0.4	1.7	1.4	1.3
Ovarian Cancer	0.8	1.0	2.0	1.2	-1.1	0.7	1.4	0.6	-0.6	1.1	1.2	1.3	-0.5
Blood Red Count	0.8	7.7	32.3	0.4	2.5	-0.3	0.8	5.7	1.1	-0.4	2.5	1.6	5.2
Blood White Count	0.8	5.6	16.8	3.3	1.6	1.5	-0.9	1.9	-1.3	-4.1	-1.9	-2.2	3.0
Hearing difficulty/problems: Yes	0.8	1.2	2.8	0.3	1.7	0.8	1.1	1.4	1.0	1.1	1.1	0.9	0.8
Diabetes (father)	0.8	1.0	4.2	-1.2	-0.3	-2.0	-1.4	-0.0	-0.4	-1.1	-0.1	-0.2	0.9
Maternal smoking around birth	0.8	1.1	5.0	0.3	-0.5	-0.9	-0.4	0.5	-0.2	-2.2	0.0	0.5	2.0
Age when periods started (menarche)	0.8	2.0	10.2	0.9	-3.2	0.7	1.8	-0.1	0.8	0.7	1.4	1.6	-0.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.4	1.2	0.5	0.7	-0.5	0.1	1.1	-1.3	-1.5	-1.3	0.1
Depression (self-reported)	0.8	0.9	2.1	0.3	-1.4	0.1	1.1	-1.1	0.3	1.4	0.8	1.2	-0.7
Medication: Lansoprazole	0.8	0.9	3.1	1.4	-0.3	0.4	0.6	1.5	0.1	-0.3	0.8	0.6	1.8
Number of children fathered	0.8	0.9	2.7	1.7	-0.4	0.4	0.8	1.3	-0.5	-0.7	0.4	0.9	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	3.5	-0.2	1.4	0.5	0.8	0.5	1.3	1.9	1.0	0.6	-0.2
Chest pain or discomfort	0.8	1.1	2.8	0.5	-1.7	0.4	-0.4	-1.3	-0.9	-1.5	-1.1	-1.2	-0.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.7	0.7	1.9	1.6	0.8	0.6	1.1	0.7	-0.3	-0.2	-0.6
Long-standing illness, disability or infirmity	0.8	1.2	5.1	-0.9	-1.2	-2.3	-1.0	0.0	0.6	-1.0	0.2	0.7	1.5
HbA1C	0.7	0.7	2.1	-0.3	0.7	-0.9	-1.3	0.0	1.5	-0.9	0.2	-0.4	1.0
Blood Platelet Count	0.7	7.8	17.3	-1.8	0.7	-2.9	-4.2	-3.7	0.8	-3.1	-4.0	-2.9	-0.2
Chronotype (morning person)	0.7	1.6	4.5	1.1	2.1	-0.1	0.5	1.5	-0.7	1.6	0.5	0.8	1.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.0	-0.6	0.7	-0.7	-1.0	0.9	-0.6	-1.4	-0.3	-0.8	0.9
Current tobacco smoking	0.7	1.1	2.8	1.4	-1.4	1.2	0.8	0.2	-1.7	-1.5	0.2	0.2	0.2
Qualifications: CSEs or equivalent	0.7	1.0	2.2	0.6	-1.3	-0.1	0.4	1.2	-1.3	-1.3	0.3	0.7	1.5
Time employed in main current job	0.7	0.8	2.0	-0.4	-0.6	-1.4	-0.3	1.2	-1.3	-0.7	0.4	0.7	1.2
Worrier / anxious feelings	0.7	1.4	3.6	0.0	-1.6	-0.4	0.1	1.7	-1.9	-1.1	1.0	0.5	1.5
Ever highly irritable/argumentative for 2 days	0.7	0.9	4.0	-0.8	-1.1	-0.1	0.5	1.0	-2.0	-0.7	0.7	0.7	0.6
Loud music exposure frequency	0.7	0.8	3.2	0.0	-1.8	-1.1	-0.6	-1.3	-0.1	-0.4	0.1	0.3	0.9
Mean time to correctly identify matches	0.7	1.3	3.8	-1.4	-1.9	-1.3	0.2	-0.7	-1.2	0.6	1.2	1.3	-0.2
Asthma (self-reported)	0.7	1.4	4.2	-0.2	2.0	1.7	0.1	0.4	1.6	0.0	-0.5	-1.5	-1.2
Rheumatoid Arthritis	0.6	0.9	2.4	-1.6	-1.4	-0.8	0.0	-1.5	-0.2	0.5	0.3	0.8	-0.6
Triglycerides	0.6	0.9	3.6	1.0	1.4	0.2	0.1	0.6	1.9	0.3	0.2	0.2	1.4
Lung FEV1/FVC ratio	0.6	3.2	10.4	0.9	-0.2	-1.0	0.7	1.3	2.7	1.3	1.9	2.2	3.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.0	-0.4	-1.4	0.3	0.9	0.6	-1.4	0.3	1.4	1.0	0.8
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.9	1.2	1.2	0.7	0.4	-0.5	1.7	0.8	-0.3	0.0	0.7
Taking other prescription medications	0.6	0.9	2.9	1.2	-0.6	0.8	0.6	1.7	-0.5	-1.4	0.3	-0.1	1.0
Hip circumference	0.6	2.7	8.2	1.5	0.5	1.4	1.7	2.9	-1.1	-0.9	1.6	1.2	2.4
Noisy workplace	0.6	0.7	1.4	-0.7	-0.8	0.6	1.1	0.9	-1.1	0.2	1.2	0.9	-0.3
Asthma	0.6	1.1	3.4	-0.3	1.8	1.4	-0.1	0.5	1.5	-0.2	-0.5	-1.4	-1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.9	0.6	1.3	1.1	-0.1	1.4	0.8	-0.5	-0.1	-1.1	0.1
Family relationship satisfaction	0.6	0.7	2.7	-1.6	-0.7	0.3	0.6	0.6	-1.3	0.5	0.7	0.3	-0.8
Leg pain on walking	0.6	0.7	1.4	1.2	-0.7	0.4	0.5	1.0	0.9	-1.0	0.0	0.5	1.2
Osteoarthritis (self-reported)	0.6	0.8	3.1	1.8	-1.2	0.3	0.0	-0.3	-1.0	-1.3	-0.4	-0.1	0.6
Smoking status: Current	0.6	0.9	2.6	1.0	-1.1	1.2	0.6	0.3	-1.6	-1.6	0.1	-0.2	0.1
Alzheimer’s Disease (in mother)	0.5	0.6	2.2	0.1	0.0	-0.7	-1.1	-0.6	1.5	-0.4	-0.8	-0.9	-0.6
Reaction Time	0.5	1.0	3.2	-1.4	-1.8	-1.0	-0.3	-0.8	-1.6	-0.1	0.4	0.4	-0.5
Body Mass Index (BMI) (2010)	0.5	0.6	1.5	-0.3	0.7	0.5	1.0	1.0	-1.2	0.7	1.0	0.7	0.2
LDL Cholesterol	0.5	0.7	2.6	1.4	0.2	0.1	0.1	0.4	1.5	-0.1	0.1	0.2	1.6
Lung FVC	0.5	2.4	4.4	-1.9	-0.7	-2.1	-2.1	-2.1	-1.6	-0.6	-1.6	-1.1	-0.7
Average weekly fortified wine intake	0.5	0.5	1.5	-0.3	0.8	1.0	0.9	0.7	1.2	0.8	0.3	0.4	-0.3
Stomach or abdominal pain in last month	0.5	0.7	3.5	0.6	-1.9	0.1	0.5	-0.8	-1.3	-0.2	0.3	0.5	0.0
Chronic bronchitis/emphysema (father)	0.5	0.6	2.0	1.2	0.2	1.4	0.8	-0.3	0.9	0.3	0.3	0.0	-0.9
Impedance of leg (left)	0.5	2.5	12.9	0.6	1.9	0.5	0.6	0.2	3.6	2.6	0.9	0.5	0.2
Nervous feelings	0.5	0.9	2.4	-0.3	-0.6	-1.1	-1.4	0.1	-0.6	-1.5	-0.2	-0.9	1.5
Medication: Simvastatin	0.5	0.8	2.4	0.7	0.9	-1.0	-0.9	0.5	0.5	-1.0	-0.9	-0.1	1.6
Trunk fat-free mass	0.5	2.8	7.3	-1.0	-0.3	-0.6	-2.1	-1.3	1.3	-2.7	-2.3	-2.5	0.3
Trunk predicted mass	0.5	2.8	7.4	-1.1	-0.4	-0.7	-2.2	-1.3	1.2	-2.7	-2.2	-2.4	0.4
Pulse wave reflection index	0.5	0.7	1.5	-0.7	-0.7	-0.2	-0.8	-0.6	-0.8	-1.2	-0.7	-0.9	-1.2
Medication: Blood pressure	0.5	1.0	2.7	0.7	-0.6	-0.8	-0.7	1.5	-0.9	-1.6	-0.4	-0.2	1.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	3.0	0.8	0.3	-0.1	0.4	-0.3	0.7	-0.6	0.3	0.9	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	1.0	0.4	0.5	0.6	0.9	1.2	-0.6	0.1	0.5	1.1
Medication: Gliclazide	0.5	0.6	1.8	-0.8	0.2	-0.4	-1.0	-0.0	-0.4	-1.1	-0.8	-1.4	-0.5
Ever taken oral contraceptive pill	0.5	0.5	1.5	-0.4	-0.9	0.9	0.8	-0.2	-0.7	0.7	0.5	0.2	-1.2
Hearing aid user	0.5	0.5	1.0	-0.7	0.4	-0.9	-1.0	0.3	0.7	-0.9	-0.6	-0.4	1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.7	-0.0	0.7	0.4	-0.4	-0.3	1.3	-0.8	-1.0	-1.2	-0.0
High cholesterol (Self-reported)	0.5	0.9	3.9	0.7	0.9	-0.9	0.1	1.3	0.2	0.1	0.1	1.2	2.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	-0.6	-0.2	-1.2	-0.8	-0.1	-0.8	-0.7	-0.5	-0.0	1.1
Worry (Nagel 2018)	0.4	0.9	2.6	-1.4	-1.6	-0.7	-0.7	0.0	-1.6	-0.7	0.4	-0.6	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	2.3	1.0	0.4	0.4	-0.5	-0.3	1.5	0.2	-0.6	-1.0	-0.9
Mean Putamen Volume	0.4	0.5	2.2	1.5	-0.0	-0.1	0.1	-0.6	1.4	0.3	0.1	0.2	0.3
Primary Biliary Cirrhosis	0.4	0.5	1.8	0.6	-1.3	-0.9	-0.2	-1.2	0.4	-0.1	0.1	0.7	0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.7	-1.3	0.3	0.5	0.1	0.6	0.2	0.8	1.0	0.0	0.6
Respiratory disease	0.4	0.8	1.7	-1.2	1.0	-0.1	-0.8	-0.3	1.3	-1.0	-0.8	-1.3	-0.4
Impedance of leg (right)	0.4	2.1	10.2	1.0	2.0	0.9	0.1	-0.4	3.2	2.1	0.0	-0.5	-0.4
Leg fat-free mass (left)	0.4	2.3	5.3	1.4	2.3	1.9	0.2	1.7	1.7	-1.3	-0.5	-1.3	1.5
Leg predicted mass (left)	0.4	2.1	4.6	1.4	2.1	1.8	0.1	1.6	1.7	-1.4	-0.6	-1.3	1.5
Alcohol usually taken with meals	0.4	0.7	3.3	-0.4	0.1	0.2	-0.3	-0.8	1.1	1.0	-0.1	-0.8	-1.8
Mouth/teeth dental problems	0.4	0.6	1.6	0.6	-0.0	-0.1	-1.0	-0.7	-0.7	-0.5	-1.0	-1.3	-0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.8	1.3	0.6	1.0	0.9	1.0	0.9	0.6	0.4	0.4	0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.5	0.9	-1.2	1.2	0.8	0.8	-0.3	-0.3	0.4	0.2	-0.3
Comparative body size at age 10	0.4	1.1	2.2	0.7	0.5	0.9	1.5	1.0	0.6	0.1	1.4	1.4	1.4
Shortness of breath walking on level ground	0.4	0.5	1.5	1.1	0.1	0.7	0.8	-0.0	1.2	0.7	0.3	0.6	0.2
Medication: Omeprazole	0.4	0.5	1.7	0.9	-1.3	0.0	0.3	0.2	-1.0	-0.9	0.4	0.3	0.4
Alcohol intake frequency.	0.4	0.9	3.9	1.0	-0.2	-0.7	-0.5	1.0	-0.4	-1.3	0.3	0.0	2.0
Knee pain experienced in last month	0.4	0.6	1.6	1.2	-0.9	-0.4	0.4	-0.4	0.6	-0.7	-0.1	1.0	1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.1	0.6	-0.8	-1.1	-0.8	-0.7	0.3	-0.8	-0.6	-0.2	0.6
Number of operations (self-reported)	0.4	0.6	2.4	0.0	-1.6	0.5	0.7	0.1	-1.4	-0.4	0.5	0.3	-0.4
Cholesterol lowering medication	0.4	0.6	2.8	0.1	0.1	-1.1	-0.1	0.9	-0.2	-0.2	0.4	1.1	1.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.1	-0.0	-1.2	-1.5	-0.6	-0.5	0.8	-0.6	-0.1	0.2	0.4
Alzheimer’s Disease (in father)	0.3	0.3	0.9	0.9	0.2	0.3	0.5	0.8	0.3	0.4	0.9	0.6	0.5
HDL Cholesterol	0.3	0.5	1.6	-0.1	-1.1	-0.1	0.5	-1.3	0.1	0.9	0.3	1.0	-0.2
Hair Pigment	0.3	9.9	21.6	-1.2	-1.3	-1.0	-3.5	-3.5	-2.5	-4.3	-4.7	-4.2	-2.5
Hearing difficulty/problems with background noise	0.3	0.5	2.0	-0.6	1.2	-0.4	-0.1	0.4	1.4	-0.2	-0.2	0.3	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.1	-0.7	0.8	1.1	-0.4	0.1	0.8	0.7	0.6	-0.6
Blood clot in the leg (DVT)	0.3	0.4	1.6	0.5	-0.8	-1.1	-0.3	-0.3	1.3	-0.4	0.0	0.4	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.6	-0.9	0.2	0.6	-0.6	0.5	0.8	0.6	0.3	-1.0
Heart disease (mother)	0.3	0.3	1.6	0.5	-0.5	-0.5	0.2	0.3	-0.2	-0.2	0.4	0.7	1.3
Whole body fat-free mass	0.3	1.5	4.8	-0.1	0.6	0.3	-1.1	0.0	1.4	-2.2	-1.5	-1.9	1.0
Leg fat-free mass (right)	0.3	1.7	3.3	0.8	1.8	1.3	-0.1	1.4	1.8	-1.5	-0.6	-1.2	1.4
Average weekly red wine intake	0.3	0.4	1.0	-0.2	0.7	0.5	-0.4	-0.3	1.0	-0.1	-0.9	-1.0	-0.7
Commuting to job workplace: Walk	0.3	0.4	1.1	-0.5	-0.7	-0.3	0.1	-0.6	-0.9	1.1	0.4	0.3	-0.3
Whole body water mass	0.3	1.4	4.8	-0.1	0.6	0.3	-1.1	0.1	1.2	-2.2	-1.4	-1.8	1.0
Leg predicted mass (right)	0.3	1.7	3.7	0.8	1.9	1.4	-0.0	1.4	1.8	-1.3	-0.5	-1.1	1.4
Average weekly champagne plus white wine intake	0.3	0.5	2.8	-0.9	0.1	-0.1	-0.2	-0.6	-0.2	0.6	-0.0	-0.2	-1.7
Basal metabolic rate	0.3	1.5	3.4	0.6	1.3	0.9	-0.3	1.2	1.5	-1.9	-0.7	-1.2	1.7
Risk taking	0.3	0.4	1.2	0.3	-0.2	-0.8	-0.7	-0.9	0.2	-1.1	-0.6	-0.4	0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.8	0.0	-1.4	-0.4	0.0	-0.3	-1.0	-0.7	0.3	0.3	0.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.3	-1.2	-0.7	-0.7	-0.3	-0.8	0.1	0.4	0.0	0.3	-0.1
Alcohol drinker status: Previous	0.3	0.3	1.2	1.1	-1.0	0.2	0.2	-0.4	-0.5	-0.0	0.0	0.1	-0.8
Birth weight	0.2	0.5	3.2	1.0	-0.1	0.6	0.5	-0.2	1.8	0.4	0.1	0.1	-0.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.2	0.7	-0.1	-0.1	-0.2	0.3	0.3	-1.1	-0.4	-0.0	0.6
Arm fat-free mass (right)	0.2	0.9	3.6	-0.0	0.4	0.4	-0.5	0.6	0.8	-1.9	-0.7	-1.1	1.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.0	0.4	0.4	-0.3	-0.4	0.3	-0.1	-1.0	-0.5	-0.2	1.0
Arm predicted mass (right)	0.2	1.0	3.1	0.3	0.7	0.7	-0.3	0.8	1.1	-1.8	-0.5	-1.0	1.6
Suffer from ‘nerves’	0.2	0.3	1.0	-0.5	-0.7	0.1	0.1	-0.0	-0.9	0.2	1.0	-0.1	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.7	-1.3	0.1	-0.1	-0.2	0.0	-0.3	0.6	0.1	-0.0	-0.5
Medication for cholesterol	0.2	0.3	1.0	-0.5	-0.2	0.7	0.3	-1.0	0.1	0.7	0.3	-0.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.4	0.0	0.4	-0.6	0.2	0.7	-0.1	1.2	0.7	0.9	1.0
Arm fat-free mass (left)	0.2	1.0	5.1	-0.2	-0.3	-0.0	-0.7	0.5	0.0	-2.3	-0.7	-1.0	1.6
Arm predicted mass (left)	0.2	1.1	5.1	-0.0	-0.2	-0.1	-0.7	0.4	0.3	-2.3	-0.8	-1.0	1.8
Tanning	0.1	1.7	6.4	2.5	0.4	1.6	1.7	1.3	0.2	0.5	1.2	1.0	0.7
Supplements: Glucosamine	0.1	0.1	0.5	-0.1	0.2	0.4	0.3	0.2	-0.1	0.1	-0.0	-0.0	-0.7
Headache pain in last month	0.1	0.2	0.6	0.7	-0.4	0.5	0.4	-0.5	0.7	0.1	0.3	0.2	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	-0.7	0.3	-0.1	-0.1	0.1	-0.4	-0.6	-0.6	0.0	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	0.1	-0.4	-0.7	-0.3	0.1	0.3	0.0	0.2	0.2	0.5

Hub : Genes

IP6K2

Models

Trait associations