[Hub]/) : Traits : Heel T-Score : ← →

chr22:40,061,683-44,282,307

Best TWAS P=6.44e-25 · Best GWAS P=3.32e-25 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EP300	0.05	0.00	bslmm	289	0.02	3.2e-03	-10.3	8.4	4.1e-17	-0.79	0.02	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NHP2L1	0.08	0.09	bslmm	299	0.10	9.9e-12	4.5	-5.5	3.7e-08	0.33	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR3H	0.24	0.31	enet	24	0.35	1.3e-44	4.6	5.3	1.0e-07	-0.27	1.00	0.00	TRUE
4	CommonMind	Brain Pre-frontal Cortex	WBP2NL	0.28	0.25	enet	16	0.35	1.3e-43	-4.7	-5.6	1.9e-08	0.07	0.90	0.10	FALSE
5	GTEx	Adipose Visceral Omentum	ADSL	0.15	0.01	enet	14	0.02	2.4e-02	4.1	5.4	5.7e-08	-0.32	0.06	0.37	FALSE
6	GTEx	Adrenal Gland	CYP2D6	0.37	0.14	lasso	12	0.16	2.3e-06	4.6	5.2	2.4e-07	-0.05	0.51	0.47	FALSE
7	GTEx	Artery Aorta	L3MBTL2	0.14	0.01	lasso	6	0.04	1.8e-03	-7.1	7.5	5.5e-14	-0.66	0.04	0.88	FALSE
8	GTEx	Artery Tibial	L3MBTL2	0.05	0.06	lasso	3	0.05	1.0e-04	-10.3	10.3	6.4e-25	-0.99	0.01	0.99	TRUE
9	GTEx	Brain Cerebellar Hemisphere	CYP2D6	0.49	0.38	enet	16	0.49	1.6e-14	4.6	5.2	1.7e-07	-0.04	0.75	0.24	FALSE
10	GTEx	Brain Cerebellar Hemisphere	CYP2D7P1	0.39	0.09	enet	12	0.20	7.2e-06	3.0	5.6	2.4e-08	-0.15	0.29	0.48	FALSE
11	GTEx	Brain Cerebellar Hemisphere	CYP2D8P1	0.23	0.04	enet	15	0.04	3.2e-02	5.4	5.7	1.6e-08	-0.16	0.10	0.37	FALSE
12	GTEx	Brain Cerebellum	CYP2D6	0.52	0.51	lasso	9	0.52	4.8e-18	4.6	5.2	2.5e-07	-0.05	0.73	0.26	FALSE
13	GTEx	Brain Frontal Cortex BA9	CYP2D6	0.51	0.20	lasso	5	0.34	9.0e-10	-4.3	5.3	9.1e-08	-0.04	0.67	0.31	FALSE
14	GTEx	Brain Frontal Cortex BA9	TTLL12	0.34	0.06	enet	21	0.10	1.6e-03	-4.6	-5.3	9.1e-08	-0.03	0.03	0.24	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	L3MBTL2	0.12	0.08	lasso	6	0.05	1.0e-02	-10.2	-10.2	3.1e-24	0.98	0.01	0.93	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	PMM1	0.20	0.16	lasso	7	0.14	1.9e-05	5.0	-5.9	4.7e-09	0.31	0.82	0.03	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	RP4-756G23.5	0.12	0.10	enet	11	0.09	5.3e-04	4.9	-5.7	1.3e-08	0.60	0.11	0.66	FALSE
18	GTEx	Cells Transformed fibroblasts	CYP2D6	0.28	0.32	lasso	6	0.33	4.1e-25	4.6	5.2	1.7e-07	-0.06	0.62	0.37	FALSE
19	GTEx	Cells Transformed fibroblasts	POLR3H	0.10	0.06	lasso	5	0.05	1.8e-04	-4.1	-5.3	1.4e-07	0.22	0.60	0.02	FALSE
20	GTEx	Cells Transformed fibroblasts	CSDC2	0.09	0.02	enet	18	0.06	3.6e-05	4.6	5.3	9.8e-08	-0.33	0.58	0.12	FALSE
21	GTEx	Cells Transformed fibroblasts	NAGA	0.12	0.15	lasso	7	0.15	1.3e-11	-4.3	-5.2	1.7e-07	0.03	0.88	0.11	FALSE
22	GTEx	Cells Transformed fibroblasts	SLC25A5P1	0.14	0.08	lasso	3	0.07	3.6e-06	5.2	-5.2	1.5e-07	0.04	0.14	0.83	FALSE
23	GTEx	Colon Sigmoid	CYP2D6	0.14	0.11	enet	7	0.13	2.9e-05	-4.2	5.3	1.5e-07	-0.06	0.48	0.15	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	CYP2D6	0.33	0.17	enet	19	0.26	5.7e-10	5.2	5.1	3.0e-07	-0.03	0.44	0.55	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	TOB2	0.16	0.01	enet	14	0.03	3.5e-02	-9.1	-8.9	6.9e-19	0.59	0.05	0.29	FALSE
26	GTEx	Esophagus Mucosa	RANGAP1	0.07	0.02	lasso	4	0.02	8.6e-03	5.6	-5.4	6.5e-08	0.38	0.21	0.25	FALSE
27	GTEx	Esophagus Mucosa	SLC25A5P1	0.09	0.10	lasso	6	0.09	1.2e-06	5.4	-5.5	4.1e-08	0.07	0.06	0.94	FALSE
28	GTEx	Esophagus Muscularis	CYP2D6	0.33	0.18	lasso	5	0.29	5.6e-18	5.2	5.7	1.5e-08	-0.04	0.30	0.70	TRUE
29	GTEx	Heart Left Ventricle	RP4-669P10.16	0.11	0.06	lasso	2	0.06	3.4e-04	4.6	5.3	9.1e-08	-0.08	0.28	0.21	FALSE
30	GTEx	Liver	L3MBTL2	0.13	0.08	lasso	7	0.09	1.3e-03	4.9	-5.2	2.0e-07	0.52	0.12	0.16	FALSE
31	GTEx	Lung	RP5-821D11.7	0.08	0.02	enet	21	0.04	6.6e-04	-4.1	-5.4	6.2e-08	0.14	0.48	0.14	FALSE
32	GTEx	Nerve Tibial	CYP2D6	0.32	0.21	lasso	6	0.24	2.8e-17	-4.2	5.5	4.2e-08	-0.05	0.93	0.06	FALSE
33	GTEx	Nerve Tibial	SLC25A5P1	0.11	0.08	lasso	5	0.06	2.9e-05	5.4	-5.5	3.9e-08	0.11	0.07	0.91	FALSE
34	GTEx	Skin Sun Exposed Lower leg	L3MBTL2	0.08	0.03	enet	16	0.06	2.1e-05	4.9	-5.7	1.5e-08	0.59	0.73	0.20	FALSE
35	GTEx	Testis	TTLL12	0.38	0.20	enet	31	0.28	6.3e-13	4.4	-6.6	5.4e-11	-0.01	0.05	0.86	TRUE
36	GTEx	Testis	TEF	0.06	0.05	lasso	5	0.04	5.5e-03	5.0	5.3	9.8e-08	-0.23	0.41	0.03	FALSE
37	GTEx	Testis	SREBF2	0.25	0.03	lasso	12	0.04	4.6e-03	-4.3	-5.2	2.4e-07	0.05	0.54	0.17	FALSE
38	GTEx	Thyroid	ZC3H7B	0.11	0.07	enet	7	0.07	3.9e-06	-9.1	-10.0	2.2e-23	0.72	0.14	0.69	FALSE
39	GTEx	Thyroid	SLC25A5P1	0.11	0.08	enet	13	0.07	3.2e-06	5.4	-5.6	1.9e-08	0.10	0.06	0.94	FALSE
40	NTR	Blood	EP300	0.04	0.00	bslmm	275	0.02	2.9e-06	-10.2	7.7	1.4e-14	-0.62	0.01	0.98	FALSE
41	NTR	Blood	TEF	0.01	0.02	lasso	2	0.02	3.8e-06	5.3	5.3	1.4e-07	-0.22	0.98	0.00	FALSE
42	YFS	Blood	EP300	0.05	0.04	blup	284	0.05	5.2e-15	-10.3	10.2	2.0e-24	-0.79	0.01	0.99	FALSE
43	YFS	Blood	NDUFA6	0.20	0.05	enet	38	0.08	1.8e-25	-4.2	-5.3	1.2e-07	0.11	0.94	0.05	FALSE
44	YFS	Blood	NHP2L1	0.02	0.00	bslmm	300	0.01	1.6e-05	4.1	7.2	4.3e-13	-0.43	0.74	0.09	FALSE
45	YFS	Blood	TEF	0.09	0.17	lasso	2	0.17	9.0e-53	5.4	5.4	8.2e-08	-0.23	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	EP300	0.01	0.00	blup	51	0.01	1.8e-02	4.9	7.1	1.5e-12	-0.74	0.04	0.44	TRUE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CYP2D6	0.14	0.09	enet	2	0.14	1.3e-07	-4.3	5.3	1.0e-07	-0.03	0.00	0.88	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	CYP2D6	0.12	0.11	enet	2	0.13	7.7e-08	-4.3	5.3	1.4e-07	-0.03	0.00	0.90	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	TEF	0.04	0.03	blup	36	0.03	9.5e-03	4.8	5.2	1.9e-07	-0.23	0.02	0.76	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TTLL12	0.10	0.01	blup	82	0.07	3.4e-08	1.0	-5.9	2.9e-09	0.00	0.01	0.15	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	WBP2NL	0.06	0.04	blup	140	0.03	9.6e-05	4.7	-5.3	1.2e-07	0.16	0.52	0.31	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADSL	0.04	0.03	enet	6	0.03	1.6e-04	5.1	6.1	9.8e-10	-0.21	0.00	0.89	TRUE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CYP2D6	0.14	0.15	enet	2	0.17	1.4e-18	-4.3	5.1	2.7e-07	-0.02	0.01	0.92	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ST13	0.14	0.11	lasso	7	0.11	4.6e-12	-5.4	5.6	2.1e-08	-0.50	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WBP2NL	0.10	0.04	blup	140	0.05	1.8e-06	5.2	-6.7	1.5e-11	0.21	0.10	0.89	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CYP2D6	0.15	0.07	blup	2	0.15	4.0e-09	-4.3	5.4	7.4e-08	-0.04	0.00	0.96	FALSE
57	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WBP2NL	0.13	0.07	lasso	4	0.03	5.2e-03	5.4	-5.4	7.5e-08	0.08	0.04	0.92	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYP2D6	0.19	0.17	enet	2	0.26	3.6e-29	4.8	5.4	7.1e-08	-0.04	0.00	0.99	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	WBP2NL	0.08	0.05	lasso	4	0.08	1.5e-09	-4.7	-5.6	2.6e-08	0.07	0.14	0.86	FALSE
60	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ST13	0.06	0.03	lasso	2	0.01	8.4e-02	-5.3	5.3	9.0e-08	-0.49	0.00	0.89	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	ADSL	0.03	0.00	blup	33	0.01	8.9e-03	5.2	5.2	2.1e-07	-0.22	0.00	0.51	TRUE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	CYP2D6	0.12	0.13	enet	2	0.15	7.4e-17	-4.3	5.2	1.6e-07	-0.03	0.01	0.92	FALSE
63	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CYP2D6	0.20	0.23	enet	2	0.25	3.4e-28	-4.3	5.2	2.3e-07	-0.03	0.01	0.92	FALSE
64	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CYP2D6	0.11	0.10	enet	2	0.11	1.1e-07	4.8	5.3	1.0e-07	-0.05	0.00	0.98	FALSE
65	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CYP2D6	0.19	0.13	enet	2	0.14	1.6e-06	-4.3	5.2	2.5e-07	-0.02	0.00	0.65	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADSL	0.08	0.02	enet	5	0.02	2.3e-03	4.4	5.2	1.7e-07	-0.26	0.03	0.37	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLR3H	0.04	0.05	blup	27	0.05	3.4e-06	4.6	-5.2	1.6e-07	0.28	0.84	0.08	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTLL12	0.07	0.02	blup	83	0.05	9.9e-06	4.4	-5.9	3.3e-09	-0.02	0.03	0.61	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	WBP2NL	0.04	0.03	lasso	8	0.03	5.6e-04	-4.7	-5.2	1.5e-07	0.06	0.21	0.63	FALSE
70	The Cancer Genome Atlas	Soft Tissue Sarcoma	CYP2D6	0.11	0.09	blup	2	0.10	1.4e-06	-4.3	5.2	2.0e-07	-0.03	0.01	0.86	FALSE
71	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CYP2D6	0.11	0.00	blup	2	0.00	2.7e-01	4.8	5.4	6.9e-08	-0.04	0.00	0.05	FALSE
72	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TEF	0.30	0.06	blup	36	0.09	1.8e-03	5.0	5.5	4.2e-08	-0.25	0.01	0.69	FALSE
73	The Cancer Genome Atlas	Stomach Adenocarcinoma	CYP2D6	0.12	0.10	blup	2	0.10	6.5e-08	-4.3	5.2	2.3e-07	-0.03	0.01	0.91	FALSE
74	The Cancer Genome Atlas	Stomach Adenocarcinoma	MKL1	0.05	0.01	blup	95	0.02	2.2e-02	-6.4	5.8	9.1e-09	-0.26	0.01	0.93	TRUE
75	The Cancer Genome Atlas	Thyroid Carcinoma	L3MBTL2	0.05	0.03	enet	9	0.04	1.8e-04	5.6	6.7	2.0e-11	-0.57	0.24	0.26	FALSE
76	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CYP2D6	0.19	0.06	blup	2	0.10	9.6e-04	-4.3	5.3	9.0e-08	-0.04	0.00	0.16	FALSE