[Hub]/) : Traits : Heel T-Score :

chr22:40,061,683-44,282,307

Best TWAS P=6.44e-25 · Best GWAS P=3.32e-25 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex EP300 0.05 0.00 bslmm 289 0.02 3.2e-03 -10.3 8.4 4.1e-17 -0.79 0.02 0.96 FALSE
2 CommonMind Brain Pre-frontal Cortex NHP2L1 0.08 0.09 bslmm 299 0.10 9.9e-12 4.5 -5.5 3.7e-08 0.33 1.00 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex POLR3H 0.24 0.31 enet 24 0.35 1.3e-44 4.6 5.3 1.0e-07 -0.27 1.00 0.00 TRUE
4 CommonMind Brain Pre-frontal Cortex WBP2NL 0.28 0.25 enet 16 0.35 1.3e-43 -4.7 -5.6 1.9e-08 0.07 0.90 0.10 FALSE
5 GTEx Adipose Visceral Omentum ADSL 0.15 0.01 enet 14 0.02 2.4e-02 4.1 5.4 5.7e-08 -0.32 0.06 0.37 FALSE
6 GTEx Adrenal Gland CYP2D6 0.37 0.14 lasso 12 0.16 2.3e-06 4.6 5.2 2.4e-07 -0.05 0.51 0.47 FALSE
7 GTEx Artery Aorta L3MBTL2 0.14 0.01 lasso 6 0.04 1.8e-03 -7.1 7.5 5.5e-14 -0.66 0.04 0.88 FALSE
8 GTEx Artery Tibial L3MBTL2 0.05 0.06 lasso 3 0.05 1.0e-04 -10.3 10.3 6.4e-25 -0.99 0.01 0.99 TRUE
9 GTEx Brain Cerebellar Hemisphere CYP2D6 0.49 0.38 enet 16 0.49 1.6e-14 4.6 5.2 1.7e-07 -0.04 0.75 0.24 FALSE
10 GTEx Brain Cerebellar Hemisphere CYP2D7P1 0.39 0.09 enet 12 0.20 7.2e-06 3.0 5.6 2.4e-08 -0.15 0.29 0.48 FALSE
11 GTEx Brain Cerebellar Hemisphere CYP2D8P1 0.23 0.04 enet 15 0.04 3.2e-02 5.4 5.7 1.6e-08 -0.16 0.10 0.37 FALSE
12 GTEx Brain Cerebellum CYP2D6 0.52 0.51 lasso 9 0.52 4.8e-18 4.6 5.2 2.5e-07 -0.05 0.73 0.26 FALSE
13 GTEx Brain Frontal Cortex BA9 CYP2D6 0.51 0.20 lasso 5 0.34 9.0e-10 -4.3 5.3 9.1e-08 -0.04 0.67 0.31 FALSE
14 GTEx Brain Frontal Cortex BA9 TTLL12 0.34 0.06 enet 21 0.10 1.6e-03 -4.6 -5.3 9.1e-08 -0.03 0.03 0.24 FALSE
15 GTEx Cells EBV-transformed lymphocytes L3MBTL2 0.12 0.08 lasso 6 0.05 1.0e-02 -10.2 -10.2 3.1e-24 0.98 0.01 0.93 FALSE
16 GTEx Cells EBV-transformed lymphocytes PMM1 0.20 0.16 lasso 7 0.14 1.9e-05 5.0 -5.9 4.7e-09 0.31 0.82 0.03 FALSE
17 GTEx Cells EBV-transformed lymphocytes RP4-756G23.5 0.12 0.10 enet 11 0.09 5.3e-04 4.9 -5.7 1.3e-08 0.60 0.11 0.66 FALSE
18 GTEx Cells Transformed fibroblasts CYP2D6 0.28 0.32 lasso 6 0.33 4.1e-25 4.6 5.2 1.7e-07 -0.06 0.62 0.37 FALSE
19 GTEx Cells Transformed fibroblasts POLR3H 0.10 0.06 lasso 5 0.05 1.8e-04 -4.1 -5.3 1.4e-07 0.22 0.60 0.02 FALSE
20 GTEx Cells Transformed fibroblasts CSDC2 0.09 0.02 enet 18 0.06 3.6e-05 4.6 5.3 9.8e-08 -0.33 0.58 0.12 FALSE
21 GTEx Cells Transformed fibroblasts NAGA 0.12 0.15 lasso 7 0.15 1.3e-11 -4.3 -5.2 1.7e-07 0.03 0.88 0.11 FALSE
22 GTEx Cells Transformed fibroblasts SLC25A5P1 0.14 0.08 lasso 3 0.07 3.6e-06 5.2 -5.2 1.5e-07 0.04 0.14 0.83 FALSE
23 GTEx Colon Sigmoid CYP2D6 0.14 0.11 enet 7 0.13 2.9e-05 -4.2 5.3 1.5e-07 -0.06 0.48 0.15 FALSE
24 GTEx Esophagus Gastroesophageal Junction CYP2D6 0.33 0.17 enet 19 0.26 5.7e-10 5.2 5.1 3.0e-07 -0.03 0.44 0.55 FALSE
25 GTEx Esophagus Gastroesophageal Junction TOB2 0.16 0.01 enet 14 0.03 3.5e-02 -9.1 -8.9 6.9e-19 0.59 0.05 0.29 FALSE
26 GTEx Esophagus Mucosa RANGAP1 0.07 0.02 lasso 4 0.02 8.6e-03 5.6 -5.4 6.5e-08 0.38 0.21 0.25 FALSE
27 GTEx Esophagus Mucosa SLC25A5P1 0.09 0.10 lasso 6 0.09 1.2e-06 5.4 -5.5 4.1e-08 0.07 0.06 0.94 FALSE
28 GTEx Esophagus Muscularis CYP2D6 0.33 0.18 lasso 5 0.29 5.6e-18 5.2 5.7 1.5e-08 -0.04 0.30 0.70 TRUE
29 GTEx Heart Left Ventricle RP4-669P10.16 0.11 0.06 lasso 2 0.06 3.4e-04 4.6 5.3 9.1e-08 -0.08 0.28 0.21 FALSE
30 GTEx Liver L3MBTL2 0.13 0.08 lasso 7 0.09 1.3e-03 4.9 -5.2 2.0e-07 0.52 0.12 0.16 FALSE
31 GTEx Lung RP5-821D11.7 0.08 0.02 enet 21 0.04 6.6e-04 -4.1 -5.4 6.2e-08 0.14 0.48 0.14 FALSE
32 GTEx Nerve Tibial CYP2D6 0.32 0.21 lasso 6 0.24 2.8e-17 -4.2 5.5 4.2e-08 -0.05 0.93 0.06 FALSE
33 GTEx Nerve Tibial SLC25A5P1 0.11 0.08 lasso 5 0.06 2.9e-05 5.4 -5.5 3.9e-08 0.11 0.07 0.91 FALSE
34 GTEx Skin Sun Exposed Lower leg L3MBTL2 0.08 0.03 enet 16 0.06 2.1e-05 4.9 -5.7 1.5e-08 0.59 0.73 0.20 FALSE
35 GTEx Testis TTLL12 0.38 0.20 enet 31 0.28 6.3e-13 4.4 -6.6 5.4e-11 -0.01 0.05 0.86 TRUE
36 GTEx Testis TEF 0.06 0.05 lasso 5 0.04 5.5e-03 5.0 5.3 9.8e-08 -0.23 0.41 0.03 FALSE
37 GTEx Testis SREBF2 0.25 0.03 lasso 12 0.04 4.6e-03 -4.3 -5.2 2.4e-07 0.05 0.54 0.17 FALSE
38 GTEx Thyroid ZC3H7B 0.11 0.07 enet 7 0.07 3.9e-06 -9.1 -10.0 2.2e-23 0.72 0.14 0.69 FALSE
39 GTEx Thyroid SLC25A5P1 0.11 0.08 enet 13 0.07 3.2e-06 5.4 -5.6 1.9e-08 0.10 0.06 0.94 FALSE
40 NTR Blood EP300 0.04 0.00 bslmm 275 0.02 2.9e-06 -10.2 7.7 1.4e-14 -0.62 0.01 0.98 FALSE
41 NTR Blood TEF 0.01 0.02 lasso 2 0.02 3.8e-06 5.3 5.3 1.4e-07 -0.22 0.98 0.00 FALSE
42 YFS Blood EP300 0.05 0.04 blup 284 0.05 5.2e-15 -10.3 10.2 2.0e-24 -0.79 0.01 0.99 FALSE
43 YFS Blood NDUFA6 0.20 0.05 enet 38 0.08 1.8e-25 -4.2 -5.3 1.2e-07 0.11 0.94 0.05 FALSE
44 YFS Blood NHP2L1 0.02 0.00 bslmm 300 0.01 1.6e-05 4.1 7.2 4.3e-13 -0.43 0.74 0.09 FALSE
45 YFS Blood TEF 0.09 0.17 lasso 2 0.17 9.0e-53 5.4 5.4 8.2e-08 -0.23 1.00 0.00 FALSE
46 The Cancer Genome Atlas Breast Invasive Carcinoma EP300 0.01 0.00 blup 51 0.01 1.8e-02 4.9 7.1 1.5e-12 -0.74 0.04 0.44 TRUE
47 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CYP2D6 0.14 0.09 enet 2 0.14 1.3e-07 -4.3 5.3 1.0e-07 -0.03 0.00 0.88 FALSE
48 The Cancer Genome Atlas Colon Adenocarcinoma CYP2D6 0.12 0.11 enet 2 0.13 7.7e-08 -4.3 5.3 1.4e-07 -0.03 0.00 0.90 FALSE
49 The Cancer Genome Atlas Colon Adenocarcinoma TEF 0.04 0.03 blup 36 0.03 9.5e-03 4.8 5.2 1.9e-07 -0.23 0.02 0.76 FALSE
50 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TTLL12 0.10 0.01 blup 82 0.07 3.4e-08 1.0 -5.9 2.9e-09 0.00 0.01 0.15 FALSE
51 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma WBP2NL 0.06 0.04 blup 140 0.03 9.6e-05 4.7 -5.3 1.2e-07 0.16 0.52 0.31 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADSL 0.04 0.03 enet 6 0.03 1.6e-04 5.1 6.1 9.8e-10 -0.21 0.00 0.89 TRUE
53 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CYP2D6 0.14 0.15 enet 2 0.17 1.4e-18 -4.3 5.1 2.7e-07 -0.02 0.01 0.92 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ST13 0.14 0.11 lasso 7 0.11 4.6e-12 -5.4 5.6 2.1e-08 -0.50 0.00 1.00 FALSE
55 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WBP2NL 0.10 0.04 blup 140 0.05 1.8e-06 5.2 -6.7 1.5e-11 0.21 0.10 0.89 FALSE
56 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CYP2D6 0.15 0.07 blup 2 0.15 4.0e-09 -4.3 5.4 7.4e-08 -0.04 0.00 0.96 FALSE
57 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma WBP2NL 0.13 0.07 lasso 4 0.03 5.2e-03 5.4 -5.4 7.5e-08 0.08 0.04 0.92 FALSE
58 The Cancer Genome Atlas Brain Lower Grade Glioma CYP2D6 0.19 0.17 enet 2 0.26 3.6e-29 4.8 5.4 7.1e-08 -0.04 0.00 0.99 FALSE
59 The Cancer Genome Atlas Brain Lower Grade Glioma WBP2NL 0.08 0.05 lasso 4 0.08 1.5e-09 -4.7 -5.6 2.6e-08 0.07 0.14 0.86 FALSE
60 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ST13 0.06 0.03 lasso 2 0.01 8.4e-02 -5.3 5.3 9.0e-08 -0.49 0.00 0.89 FALSE
61 The Cancer Genome Atlas Lung Adenocarcinoma ADSL 0.03 0.00 blup 33 0.01 8.9e-03 5.2 5.2 2.1e-07 -0.22 0.00 0.51 TRUE
62 The Cancer Genome Atlas Lung Adenocarcinoma CYP2D6 0.12 0.13 enet 2 0.15 7.4e-17 -4.3 5.2 1.6e-07 -0.03 0.01 0.92 FALSE
63 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CYP2D6 0.20 0.23 enet 2 0.25 3.4e-28 -4.3 5.2 2.3e-07 -0.03 0.01 0.92 FALSE
64 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CYP2D6 0.11 0.10 enet 2 0.11 1.1e-07 4.8 5.3 1.0e-07 -0.05 0.00 0.98 FALSE
65 The Cancer Genome Atlas Pancreatic Adenocarcinoma CYP2D6 0.19 0.13 enet 2 0.14 1.6e-06 -4.3 5.2 2.5e-07 -0.02 0.00 0.65 FALSE
66 The Cancer Genome Atlas Prostate Adenocarcinoma ADSL 0.08 0.02 enet 5 0.02 2.3e-03 4.4 5.2 1.7e-07 -0.26 0.03 0.37 FALSE
67 The Cancer Genome Atlas Prostate Adenocarcinoma POLR3H 0.04 0.05 blup 27 0.05 3.4e-06 4.6 -5.2 1.6e-07 0.28 0.84 0.08 FALSE
68 The Cancer Genome Atlas Prostate Adenocarcinoma TTLL12 0.07 0.02 blup 83 0.05 9.9e-06 4.4 -5.9 3.3e-09 -0.02 0.03 0.61 FALSE
69 The Cancer Genome Atlas Prostate Adenocarcinoma WBP2NL 0.04 0.03 lasso 8 0.03 5.6e-04 -4.7 -5.2 1.5e-07 0.06 0.21 0.63 FALSE
70 The Cancer Genome Atlas Soft Tissue Sarcoma CYP2D6 0.11 0.09 blup 2 0.10 1.4e-06 -4.3 5.2 2.0e-07 -0.03 0.01 0.86 FALSE
71 The Cancer Genome Atlas Skin Cutaneous Melanoma CYP2D6 0.11 0.00 blup 2 0.00 2.7e-01 4.8 5.4 6.9e-08 -0.04 0.00 0.05 FALSE
72 The Cancer Genome Atlas Skin Cutaneous Melanoma TEF 0.30 0.06 blup 36 0.09 1.8e-03 5.0 5.5 4.2e-08 -0.25 0.01 0.69 FALSE
73 The Cancer Genome Atlas Stomach Adenocarcinoma CYP2D6 0.12 0.10 blup 2 0.10 6.5e-08 -4.3 5.2 2.3e-07 -0.03 0.01 0.91 FALSE
74 The Cancer Genome Atlas Stomach Adenocarcinoma MKL1 0.05 0.01 blup 95 0.02 2.2e-02 -6.4 5.8 9.1e-09 -0.26 0.01 0.93 TRUE
75 The Cancer Genome Atlas Thyroid Carcinoma L3MBTL2 0.05 0.03 enet 9 0.04 1.8e-04 5.6 6.7 2.0e-11 -0.57 0.24 0.26 FALSE
76 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma CYP2D6 0.19 0.06 blup 2 0.10 9.6e-04 -4.3 5.3 9.0e-08 -0.04 0.00 0.16 FALSE