Hub : Genes

GPR75

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.2052	0.0878	6.2e-03	0.003	NA	0.031	NA	0.013	2.6e-01	NA	5.1e-02	NA	1.4e-01
2	GTEx	Brain Hypothalamus	0.3300	0.1130	4.1e-03	0.013	NA	0.019	NA	0.025	1.5e-01	NA	1.2e-01	NA	8.7e-02
3	GTEx	Lung	0.0586	0.0245	1.1e-03	0.022	NA	0.038	NA	0.042	7.4e-03	NA	6.2e-04	NA	3.4e-04
4	ROSMAP	Brain Pre-frontal Cortex	0.1703	0.0351	4.4e-16	0.128	0.133	0.158	0.156	0.159	4.3e-16	9.2e-17	8.9e-20	1.6e-19	7.0e-20
5	TCGA	Brain Lower Grade Glioma	0.0625	0.0410	1.9e-03	0.001	0.013	0.015	NA	0.008	2.3e-01	1.2e-02	6.5e-03	NA	3.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	2.4	3.8	8.2	1.6	0.6	-2.0	1.9	2.9
Bipolar Disorder or Schizophrenia	1.4	3.5	6.7	2.6	-1.1	-1.5	2.5	1.1
Depressed Affect (Nagel 2018)	0.7	1.4	3.0	0.6	0.8	-0.9	1.7	1.5
Depression (Nagel 2018)	2.1	3.1	6.3	0.4	1.5	-1.3	2.3	2.5
Intelligence (Savage-Jansen 2018)	1.8	5.6	14.4	0.6	-3.8	2.2	-0.5	-2.8
Neuroticism (Nagel 2018)	0.7	1.7	4.2	0.8	-1.5	0.4	2.1	1.2
Schizophrenia (2018)	1.1	2.3	4.3	2.1	-1.8	-0.3	1.7	-0.8
Schizophrenia vs Biploar Disorder	1.4	1.9	3.8	0.3	-1.9	-0.1	1.4	-1.9
Worry (Nagel 2018)	0.7	1.4	4.0	-0.4	-2.0	1.4	0.4	0.9
Alzheimer’s Disease (in mother)	1.3	1.5	2.2	1.5	-0.3	-1.2	1.4	1.4
Alzheimer’s Disease (in father)	0.8	0.9	2.0	1.4	-0.5	-0.9	0.8	0.8
Alzheimer’s Disease (including proxy)	1.3	1.9	4.0	2.0	-0.7	-1.1	1.4	1.4
Crohns Disease (2017)	2.2	4.8	7.8	2.2	0.7	-2.0	2.8	2.6
Irritable Bowel Disease (IBD)	0.9	2.2	3.5	1.8	1.1	-1.5	1.0	1.9
Ulcerative Colitis (UC)	0.2	0.4	0.9	0.5	0.5	0.1	-1.0	0.6
Major Depression (MDD)	0.1	0.1	0.4	-0.2	0.0	0.1	0.7	-0.2
Reaction Time	0.5	0.9	2.4	0.1	-1.3	1.6	-0.4	0.3
Verbal and Numeric Reasoning (VNR)	3.1	7.5	18.6	0.1	-4.3	3.2	-0.2	-2.9
Breast Cancer	0.1	0.3	0.7	-0.9	0.4	0.3	-0.4	-0.4
Ovarian Cancer	0.4	0.6	1.3	0.6	0.2	-0.4	1.0	1.1
Prostate Cancer	0.6	0.8	2.5	-0.6	0.6	-0.0	0.8	1.6
Age at First Birth	0.4	0.5	1.0	0.7	0.4	-0.9	0.3	-1.0
Bipolar Disorder (2011)	0.7	0.7	1.2	0.8	-1.1	0.5	0.8	0.9
Body Mass Index (BMI) (2010)	2.8	3.9	5.1	-1.9	-2.3	2.3	-1.2	-2.0
Coronary Artery Disease (CAD)	0.3	0.4	0.7	-0.7	0.4	-0.3	-0.8	0.7
Crohns Disease (2012)	1.2	1.9	3.1	1.8	0.7	-1.2	1.5	1.4
Mean Putamen Volume	0.4	0.4	1.2	-0.3	-0.1	0.5	-0.7	-1.1
Fasting Glucose	1.2	1.5	2.3	-0.4	1.5	0.4	-1.5	-1.5
HbA1C	1.0	1.1	3.4	-1.0	-0.4	1.8	-0.5	-0.8
HDL Cholesterol	2.3	3.8	7.9	0.8	2.8	-2.6	-0.0	1.9
LDL Cholesterol	1.3	2.0	3.1	1.3	1.8	-1.6	0.7	1.5
Lupus	0.6	0.9	2.5	1.1	0.6	-0.3	0.8	1.6
Neuroticism (2016)	1.7	2.4	5.7	1.0	-2.4	0.5	1.9	1.3
Primary Biliary Cirrhosis	0.4	0.5	0.9	0.7	0.9	-0.7	0.6	-0.7
Rheumatoid Arthritis	1.9	2.6	5.0	1.6	2.0	-2.2	1.2	0.6
Schizophrenia (2014)	1.9	4.2	7.5	2.4	-2.7	-0.1	2.5	-1.1
Triglycerides	0.7	1.1	3.7	0.1	-1.9	1.0	0.8	-0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.3	-0.8	-0.6	1.1	-0.8	-1.2
Ulcerative Colitis	0.3	0.4	1.0	1.0	0.1	-0.0	-1.0	0.3
Blood Eosinophil Count	0.1	0.8	1.5	1.2	-1.2	-0.5	0.9	-0.6
Blood Platelet Count	0.7	7.7	25.6	1.7	0.4	-2.8	1.4	5.1
Blood Red Count	0.4	3.9	10.6	-2.1	0.4	1.2	-3.3	-1.8
Blood White Count	0.3	2.4	3.5	1.5	0.3	-1.8	1.7	1.9
Heel T-Score	2.0	15.7	33.6	-4.8	3.5	1.7	-5.8	2.6
BMI	2.2	12.6	27.0	-2.3	-5.2	5.1	0.3	-2.1
Height	0.1	2.4	11.4	-0.2	-0.7	-0.3	3.4	-0.3
Waist Hip Ratio (WHR)	0.0	0.2	0.3	-0.1	0.3	-0.5	0.5	-0.4
Systolic Blood Pressure	1.3	6.6	10.0	2.2	1.2	-3.0	2.7	3.2
Smoking Status	1.6	3.9	12.2	1.1	-2.4	0.9	3.5	-0.1
Allergy or Eczema	0.5	1.3	3.3	1.5	-1.8	-0.7	0.7	0.3
Cardiovascular Disease	0.7	2.4	9.9	0.5	-1.3	-0.2	3.1	-0.3
Hypothyroidism (self reported)	0.1	0.3	0.7	0.7	-0.2	0.2	0.2	-0.9
Respiratory disease	0.6	1.3	3.6	1.3	-1.9	0.1	0.9	-0.8
Type 2 Diabetes (T2D) (2018)	1.6	3.1	4.5	-2.0	-1.9	2.1	-0.0	-1.9
Lung FEV1/FVC ratio	1.4	7.0	15.4	0.7	1.8	-1.0	3.8	3.9
Lung FVC	1.0	5.2	12.5	0.3	3.5	-1.4	-3.2	0.9
Neuroticism	0.3	0.8	2.6	0.0	-1.6	0.8	0.5	0.6
Chronotype (morning person)	1.9	4.4	7.6	0.7	1.9	-2.2	2.4	2.8
Hair Pigment	0.0	0.7	1.7	1.3	0.2	-1.2	-0.4	0.4
Tanning	0.2	1.9	4.8	-0.7	2.2	-1.0	0.3	1.7
Hand grip strength (left)	1.6	4.2	8.6	-0.8	2.9	-1.9	0.6	2.7
Number of treatments/medications taken	1.1	2.0	4.0	1.4	0.8	-2.0	1.3	1.2
Average weekly spirits intake	3.5	4.4	8.5	-1.4	-1.7	2.5	-2.9	-1.6
Sensitivity / hurt feelings	0.2	0.3	0.7	0.6	-0.8	0.1	0.2	-0.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.4	-0.6	0.6	0.0	1.0	1.6
Hearing difficulty/problems: Yes	0.3	0.5	1.8	-0.3	1.3	-0.7	0.3	0.4
Relative age of first facial hair	0.7	1.3	3.0	1.5	-0.3	-1.0	1.7	0.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	2.7	0.3	1.6	-1.5	1.0	-0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	4.1	0.1	-0.5	0.1	-0.3	2.0
Ever had hysterectomy (womb removed)	0.5	0.5	1.3	-0.9	1.1	-0.5	0.5	0.3
Systolic blood pressure, automated reading	0.8	2.3	5.9	0.6	-0.1	-1.2	1.9	2.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.5	0.5	1.0	-0.8	1.2	0.6
Angina	2.1	2.8	5.1	2.3	0.2	-1.2	1.7	2.1
Medication for hormone replacement therapy	0.8	0.9	4.2	-0.1	0.4	-0.1	-2.0	-0.4
Vitamin and mineral supplements	0.3	0.4	1.4	1.2	0.5	-0.1	0.3	0.2
Supplements: Zinc	0.3	0.3	0.7	0.2	0.4	-0.2	-0.9	0.8
Medication: Co-codamol	1.6	1.8	4.5	1.0	0.4	-1.3	2.1	1.3
Medication: Metformin	0.4	0.6	2.2	-1.5	0.5	0.6	0.5	-0.3
Diabetes (father)	0.8	1.0	2.3	-0.8	0.7	0.7	-1.2	-1.5
Diabetes (mother)	0.2	0.3	0.7	0.8	0.4	-0.1	0.5	0.7
Severe depression (siblings)	2.0	2.3	4.3	-1.2	-0.7	1.5	-1.7	-2.1
Pack years adult smoking proportion	0.6	0.9	3.2	0.4	0.4	-0.9	1.8	0.5
Impedance of leg (right)	0.2	0.7	2.3	1.5	0.2	-1.1	-0.3	-0.5
Leg fat-free mass (left)	0.4	2.2	3.1	-1.6	-1.7	1.8	1.3	-0.7
Trunk fat percentage	1.8	7.1	13.5	-1.8	-3.7	3.3	0.7	-2.6
Hand grip strength (right)	2.4	6.6	10.4	0.8	2.9	-3.2	1.8	3.2
Townsend deprivation index at recruitment	2.2	3.1	9.4	-1.1	-3.1	1.7	0.8	-1.1
Current tobacco smoking	1.3	2.1	8.3	0.7	-1.2	-0.2	2.9	0.2
Average weekly fortified wine intake	1.1	1.3	2.5	-1.4	1.6	-0.4	-1.2	-0.6
Maternal smoking around birth	0.1	0.2	0.5	0.2	0.7	-0.6	-0.1	-0.2
Fed-up feelings	0.5	1.0	2.7	0.7	0.2	-0.0	1.4	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.9	-0.9	1.7	-0.7	0.8	1.5
Relative age voice broke	0.3	0.5	2.3	-0.4	0.2	-0.3	1.5	0.1
Taking other prescription medications	0.9	1.4	3.8	1.6	0.5	-2.0	0.5	0.3
Age when periods started (menarche)	0.7	1.7	5.0	0.2	2.2	-1.3	-1.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	0.5	-0.1	-0.7	1.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	6.9	-0.4	2.6	-1.1	-1.0	1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.0	-0.8	-0.4	0.3	-1.0	-0.8
Qualifications: CSEs or equivalent	0.5	0.6	1.6	-0.8	1.3	-0.3	-0.6	-0.5
Serious illness, injury or assault to yourself	0.4	0.4	1.7	0.1	1.3	-0.0	-0.1	-0.7
High blood pressure	1.2	3.3	13.7	1.0	-0.7	-0.9	3.7	0.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.9	0.1	-1.7	-0.1	-0.3	-0.3
Multivitamins +/- minerals	0.4	0.6	2.0	-1.4	-0.6	0.5	-0.4	0.1
Stomach or abdominal pain in last month	0.4	0.5	0.9	-0.7	-1.0	0.2	0.3	-0.9
Supplements: Glucosamine	1.7	2.2	5.5	-1.2	1.5	0.8	-2.4	-1.1
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	7.5	-0.3	-2.7	2.0	0.8	-0.6
Medication: Atenolol	0.4	0.5	1.4	-0.5	-0.3	-0.3	0.8	1.2
Medication: Levothyroxine sodium	0.3	0.5	0.7	-0.1	-0.8	0.8	0.6	-0.8
Sitting height	0.2	1.7	7.2	0.0	-0.3	-0.9	2.7	0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	1.6	1.3	0.4	-1.1	1.0	0.3
High blood pressure (mother)	0.2	0.3	0.5	0.5	-0.1	0.5	0.7	0.6
Body mass index (BMI)	1.9	7.9	17.1	-2.3	-3.7	4.1	0.5	-1.8
Impedance of leg (left)	0.1	0.6	1.5	1.0	0.3	-1.2	-0.6	-0.4
Leg predicted mass (left)	0.4	2.1	2.9	-1.6	-1.6	1.7	1.4	-0.6
Trunk fat mass	1.8	7.6	15.1	-1.9	-3.9	3.5	0.9	-2.5
Waist circumference	2.1	7.7	14.8	-2.1	-3.7	3.9	0.7	-2.3
Number of incorrect matches in round	1.2	2.0	4.4	-0.5	2.1	-1.1	0.8	1.9
Past tobacco smoking	1.9	3.4	7.1	-0.7	2.7	-1.7	-2.5	0.5
Alcohol usually taken with meals	0.5	0.8	1.8	0.4	1.4	-0.9	-0.4	1.0
Nervous feelings	0.8	1.4	5.2	0.2	-2.3	0.9	0.9	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.2	-0.3	0.3	0.1	-0.0
Hearing difficulty/problems with background noise	0.4	0.7	2.2	-0.8	0.3	1.5	0.7	0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.1	1.0	0.0	-0.8	1.0	-0.1
Had menopause	0.8	1.1	2.6	-0.1	-1.6	1.3	0.7	-0.6
Had other major operations	0.2	0.3	1.0	-0.6	-0.0	0.0	1.0	-0.0
Forced vital capacity (FVC)	0.3	1.3	2.5	-0.6	1.6	-1.0	-0.6	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.2	-0.8	1.8	-0.1	-1.8	0.3
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.4	0.2	0.7	-1.6	1.3	0.8
Qualifications: None of the above	0.1	0.2	0.6	-0.8	0.2	0.6	-0.5	0.2
Financial difficulties in last 2 years	2.2	2.9	3.8	-1.8	-1.9	1.9	-1.4	-1.3
Mouth/teeth dental problems	0.6	0.9	2.6	-0.7	-0.3	0.7	-0.9	-1.6
Heart attack	0.6	0.8	2.2	-0.1	-0.5	0.4	-1.5	-1.2
Allergy	0.3	0.7	2.6	-0.3	1.6	0.1	0.2	0.7
Pain all over the body in last month	1.6	1.7	4.9	-2.2	0.7	1.3	-1.2	-0.1
Diabetes (self-reported)	1.7	2.6	6.9	-2.6	-0.4	1.7	-0.9	-1.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.3	-0.6	-0.2	-0.5	-0.3	-0.6
Medication: Ramipril	0.5	0.7	1.6	-0.4	0.4	-0.6	1.1	1.3
Medication: Simvastatin	0.8	1.2	1.7	1.3	-0.9	-1.3	1.2	0.3
Fluid intelligence score	2.0	4.3	14.1	1.0	-3.8	1.6	0.3	-1.8
Illnesses of siblings	0.8	1.1	2.9	-1.0	0.2	0.2	-1.7	-1.1
Neuroticism score	0.3	0.7	2.2	0.2	-1.5	0.7	0.7	0.4
Weight	1.5	7.3	13.5	-2.0	-3.7	3.5	1.8	-1.8
Impedance of arm (right)	0.4	1.7	4.2	1.7	0.7	-2.0	0.7	-0.6
Arm fat percentage (right)	1.6	6.4	11.5	-1.4	-3.4	3.4	0.9	-2.5
Trunk fat-free mass	0.2	1.3	3.2	-0.8	-1.3	1.0	1.8	-0.2
Hip circumference	1.4	6.0	11.5	-2.3	-3.1	3.4	0.6	-1.8
Time employed in main current job	3.6	4.2	7.6	2.5	1.0	-1.6	2.8	1.9
Alcohol intake versus 10 years previously	0.3	0.5	2.2	-0.3	0.1	0.3	1.5	0.0
Father’s age at death	0.7	0.9	3.3	1.1	-1.8	0.4	-0.3	-0.3
Worrier / anxious feelings	0.8	1.5	2.7	1.1	-0.8	-0.8	1.5	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.5	0.3	0.8	-1.2	-0.1	-0.0
Falls in the last year	0.3	0.5	1.3	0.7	-0.5	-0.4	1.1	-0.2
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	-0.7	0.1	1.2	-0.5	0.1
Number of live births	1.1	1.6	2.9	-1.3	-0.5	1.5	-0.9	-1.7
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	5.3	-0.5	2.0	-1.1	0.5	2.3
Pulse rate	2.5	4.2	10.4	-2.3	1.3	0.8	-3.2	-1.6
Happiness	3.4	4.1	8.8	1.9	1.0	-1.8	3.0	2.0
Noisy workplace	0.2	0.3	0.6	-0.5	0.4	0.4	-0.3	0.7
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.9	2.0	-0.2	-1.1	2.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.5	0.7	-0.5	-0.1	-0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.5	0.3	-0.4	0.5	0.7	1.2
Asthma	1.0	2.0	5.9	1.1	-2.4	0.3	0.8	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.2	-1.5	0.6	0.4	-0.7	-1.0
Medication: Cholesterol lowering	0.5	0.8	3.3	0.2	-0.6	-0.4	1.8	0.5
Depression (self-reported)	0.1	0.1	0.2	0.1	-0.3	-0.4	-0.4	-0.2
Medication: Lansoprazole	0.3	0.3	1.7	0.2	-0.0	0.1	-0.1	-1.3
Prospective memory result	4.0	4.9	11.6	3.4	-0.1	-2.0	2.7	1.3
Lung cancer (father)	0.7	0.8	2.8	0.4	-0.7	-0.0	0.9	-1.7
Illnesses of mother	0.3	0.4	0.7	-0.9	0.2	-0.2	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.9	-0.6	1.9	-0.8	-0.0	2.0
Pulse wave Arterial Stiffness index	2.5	3.0	7.6	-1.2	-2.4	2.8	0.1	-0.2
Impedance of arm (left)	0.3	1.2	2.5	1.2	0.9	-1.6	0.1	-1.0
Arm fat mass (right)	1.8	7.4	13.9	-2.1	-3.5	3.7	1.1	-2.4
Trunk predicted mass	0.2	1.4	3.0	-0.9	-1.3	1.1	1.7	-0.2
Standing height	0.2	2.0	8.6	0.3	-0.3	-1.0	2.9	-0.2
Length of working week for main job	0.2	0.3	0.8	0.0	-0.4	0.9	0.4	-0.5
Exposure to tobacco smoke at home	0.6	0.7	1.5	0.1	-0.8	1.2	0.1	-1.2
Breastfed as a baby	0.3	0.3	0.7	-0.8	0.2	0.8	-0.2	-0.4
Tense / ‘highly strung’	2.3	3.7	8.6	-0.7	-2.8	2.9	-1.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.8	0.1	-1.0	-0.5	1.7	1.1
Hair/balding pattern: Pattern 4	0.7	1.6	4.8	-2.2	-0.3	1.1	-1.4	0.4
Birth weight of first child	0.2	0.4	1.2	1.1	0.3	-0.5	0.5	-0.0
Peak expiratory flow (PEF)	0.3	0.7	1.8	-1.0	1.3	-0.1	0.5	0.8
Pulse wave reflection index	0.7	0.9	1.5	0.7	-0.9	0.3	1.2	1.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.7	1.6	1.1	-1.3	1.4	0.9
Loud music exposure frequency	1.1	1.2	3.2	-0.1	-1.8	1.0	0.1	-1.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	-0.1	-0.4	-0.5	0.8	-0.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	2.8	-0.1	1.2	-1.7	1.4	1.4
Blood clot in the leg (DVT)	0.6	0.7	1.7	-0.6	-0.5	0.8	-1.3	-0.7
Medication: Paracetamol	1.5	2.5	5.3	-1.1	-2.3	1.7	0.1	-1.8
Headache pain in last month	0.5	0.8	2.3	0.4	-1.1	-0.0	1.5	-0.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	6.4	-0.9	0.4	0.5	-2.5	-1.1
Glaucoma (self-reported)	2.8	3.3	5.3	-2.3	2.2	0.2	-1.8	1.6
Gout (self-reported)	0.2	0.3	0.7	-0.6	0.8	-0.1	0.6	0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	1.1	-0.3	-0.0	0.2	-1.0
Medication: Amlodipine	2.5	3.5	11.5	1.7	0.1	-0.9	3.4	1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.6	-0.0	1.9	-1.1	-0.6	0.5
Birth weight	0.2	0.4	1.1	-1.1	-0.2	0.7	0.0	0.7
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	1.4	-0.0	-0.9	1.3	-0.5
High blood pressure (siblings)	0.5	0.8	2.0	0.5	-0.2	0.5	1.4	1.1
Forced vital capacity (FVC), Best measure	0.3	1.0	2.2	-0.6	1.5	-0.8	-0.7	1.1
Body fat percentage	1.8	7.1	14.0	-1.6	-3.7	3.5	0.6	-2.6
Leg fat percentage (right)	2.4	8.6	17.0	-1.6	-4.0	4.1	0.2	-2.6
Arm fat-free mass (right)	0.3	1.7	2.7	-1.6	-1.3	1.6	1.2	-0.3
Exposure to tobacco smoke outside home	1.6	2.1	4.3	-0.7	-2.1	1.9	1.5	-0.4
Comparative body size at age 10	0.6	1.7	5.8	-1.3	-0.9	2.4	-0.2	0.3
Number of full brothers	1.2	1.5	3.9	-0.8	-2.0	1.5	-0.3	-0.8
Worry too long after embarrassment	0.3	0.4	0.9	0.9	-0.7	-0.1	0.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	1.1	-0.9	-0.6	1.2	0.6
Wheeze or whistling in the chest in last year	0.4	0.8	1.6	1.3	-0.9	-0.3	1.0	-0.7
Number of children fathered	1.4	1.5	3.7	-0.2	0.1	0.5	-1.9	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	5.0	5.8	8.8	1.3	2.5	-3.0	2.3	2.7
Age at first live birth	0.6	1.1	2.7	-0.8	-0.1	0.8	-1.7	-1.1
Pulse wave peak to peak time	3.0	3.6	9.1	1.5	2.5	-3.0	0.2	0.3
Health satisfaction	1.5	1.9	2.2	1.2	1.5	-1.4	1.4	1.4
Shortness of breath walking on level ground	0.2	0.3	0.7	-0.6	0.9	-0.0	-0.5	0.3
Qualifications: College or University degree	0.1	0.4	1.3	1.1	-0.1	-0.2	0.7	0.1
Eye problems/disorders: None of the above	1.0	1.1	3.5	1.1	-1.9	0.6	0.7	-0.2
Mouth/teeth dental problems: Loose teeth	1.3	1.6	2.9	1.4	0.5	-1.3	1.7	1.0
Emphysema/chronic bronchitis	0.7	0.8	2.4	0.3	-0.7	0.9	-0.6	-1.6
Medication for pain relief, constipation, heartburn	0.9	1.5	2.6	0.8	1.6	-1.4	-0.5	1.5
Neck or shoulder pain in last month	1.3	1.9	4.3	1.5	1.3	-2.1	0.3	1.0
Medication: Blood pressure	1.8	3.2	8.8	1.6	0.2	-0.9	3.0	2.0
Angina (self-reported)	1.8	2.3	4.7	2.2	0.1	-1.1	1.6	1.8
Migraine (self-reported)	0.3	0.3	1.4	1.2	-0.2	-0.1	0.4	0.1
Medication: Ibuprofen	0.7	0.9	3.0	-1.7	0.6	0.1	-0.6	-0.7
Medication: Allopurinol	0.3	0.3	1.4	0.2	-0.0	-0.5	1.2	0.1
Medication: Omeprazole	0.8	0.9	1.3	1.1	0.9	-1.1	0.3	1.1
Medication: Seretide 50 evohaler	0.3	0.4	1.4	-1.2	-0.2	0.1	0.6	-0.1
Mean time to correctly identify matches	0.5	0.9	2.2	0.4	-1.3	1.5	-0.5	-0.0
Heart disease (mother)	0.5	0.6	2.4	0.7	-1.5	0.6	0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.8	1.7	0.2	-1.6	1.0	0.6
Whole body fat mass	1.9	7.9	14.6	-2.0	-3.8	3.7	0.8	-2.6
Leg fat mass (right)	1.9	7.3	14.5	-2.0	-3.7	3.8	0.6	-2.0
Arm predicted mass (right)	0.4	1.9	3.1	-1.6	-1.5	1.8	1.2	-0.2
Pulse rate, automated reading	1.4	4.5	8.7	-2.3	3.0	0.6	-2.9	-0.3
Alcohol intake frequency.	0.4	1.0	3.2	0.3	1.8	-1.1	-0.7	0.5
Comparative height size at age 10	0.4	2.1	7.6	0.6	-1.5	-0.6	2.8	-0.1
Number of full sisters	1.3	1.6	3.3	1.6	-0.5	-0.2	-1.4	-1.8
Suffer from ‘nerves’	1.1	1.7	5.2	-0.3	-2.3	1.4	0.9	0.6
Overall health rating	1.0	2.2	4.3	0.9	1.7	-2.1	1.7	0.7
Chest pain or discomfort	1.2	1.8	3.5	1.7	0.4	-1.2	1.9	0.9
Had major operations	1.4	1.7	4.5	1.4	0.1	-0.9	1.1	2.1
Age at last live birth	0.5	0.7	1.7	-0.4	0.0	-0.0	-1.3	-1.2
Family relationship satisfaction	1.3	1.6	4.8	0.2	1.1	-1.1	2.2	0.8
Leg pain on walking	0.5	0.6	1.5	-1.1	0.2	1.2	-0.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.7	2.2	0.5	-2.1	1.5	0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.0	-0.7	0.0	1.4	0.3	0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.1	-0.4	-0.0	0.4	0.5	1.0
Medication: Aspirin	0.5	0.7	2.1	0.1	-1.0	1.4	0.5	-0.2
Supplements: Vitamin C	0.3	0.4	0.6	-0.7	-0.8	0.7	-0.2	-0.5
Knee pain experienced in last month	3.5	5.5	9.9	-2.2	-1.5	3.1	-1.1	-3.2
Hypertension (Self-reported)	1.6	4.5	17.1	1.6	-0.6	-1.3	4.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.6	1.6	0.5	-0.7	0.6	0.2
Illnesses of father: Heart disease	0.5	0.6	1.4	-1.2	0.3	0.5	-1.0	0.7
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.1	0.3	-0.4	-0.4	0.5
Smoking status: Previous	2.2	3.2	7.3	-0.1	-2.7	2.6	1.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.4	1.0	1.0	-1.9	1.0	0.3
Whole body fat-free mass	0.3	1.7	2.9	-1.4	-1.4	1.3	1.7	-0.2
Leg fat-free mass (right)	0.4	2.0	3.3	-1.8	-1.5	1.6	1.4	-0.5
Arm fat percentage (left)	1.6	6.6	12.8	-1.6	-3.3	3.6	0.5	-2.5
Average weekly red wine intake	0.2	0.3	0.8	0.8	-0.0	-0.9	0.1	0.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.9	-0.6	-0.2	0.2	1.7	0.2
Mood swings	0.1	0.2	0.5	-0.3	-0.7	0.6	0.1	0.1
Loneliness, isolation	0.2	0.3	1.3	-1.1	0.6	0.0	-0.2	0.0
Long-standing illness, disability or infirmity	0.8	1.2	2.6	0.6	1.0	-1.6	1.3	0.4
Ever had bowel cancer screening	0.3	0.4	0.8	0.6	-0.9	-0.0	0.5	0.9
Diabetes diagnosed by doctor	1.0	1.6	4.8	-2.2	-0.3	1.4	-0.4	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.0	0.1	1.3	-1.4	-0.6	-1.0
Friendships satisfaction	0.6	0.7	3.0	-0.3	0.4	0.3	1.7	0.5
Qualifications: nursing, teaching	0.5	0.8	2.1	1.1	-0.7	-0.1	-0.1	-1.4
Commuting to job workplace: Walk	0.3	0.3	1.2	-0.3	-0.1	-1.1	0.0	0.3
Eye problems/disorders: Cataract	1.1	1.3	2.1	-0.5	1.4	-1.4	1.2	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	3.0	1.7	0.2	-0.8	0.0	-0.0
Medication for cholesterol	0.1	0.2	0.3	-0.6	0.6	0.0	-0.0	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.5	1.2	1.0	-1.1	-0.2	0.3
Back pain experienced in last month	0.6	0.8	2.4	-0.1	0.8	-1.6	0.7	-0.8
Mineral and other dietary supplements	0.5	0.7	2.2	0.4	0.6	-0.8	1.5	0.6
Breast cancer (self-reported)	2.0	2.4	7.1	-1.5	2.7	-1.3	-0.3	1.0
Asthma (self-reported)	1.0	2.0	6.3	0.8	-2.5	0.6	0.8	-1.4
Osteoporosis (self-reported)	0.2	0.2	0.4	0.5	0.2	-0.3	-0.6	-0.4
Osteoarthritis (self-reported)	1.0	1.4	3.0	-1.6	0.3	1.0	-0.5	-1.7
Medication: Aspirin	0.4	0.5	1.5	-0.1	-0.8	1.2	0.7	0.3
Medication: Gliclazide	0.3	0.3	0.8	-0.9	-0.0	0.8	0.3	-0.2
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.5	-0.3	0.8	0.3	-0.1
Smoking status: Current	1.3	2.1	8.0	0.8	-1.3	-0.1	2.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	5.6	-1.4	-0.4	1.2	-2.4	0.3
Whole body water mass	0.3	1.7	3.1	-1.3	-1.4	1.3	1.8	-0.2
Leg predicted mass (right)	0.4	2.0	3.5	-1.9	-1.5	1.6	1.3	-0.6
Arm fat mass (left)	1.8	7.4	13.7	-2.2	-3.4	3.7	1.0	-2.4
Number of self-reported non-cancer illnesses	0.4	0.8	2.5	0.4	-0.3	-1.0	1.6	-0.1
Average weekly champagne plus white wine intake	0.9	1.2	2.4	0.3	1.2	-1.0	1.6	0.9
Miserableness	0.9	1.6	5.1	-0.3	0.1	0.2	2.2	1.6
Guilty feelings	0.8	1.2	4.0	-0.4	-2.0	1.0	-0.0	-0.9
Wears glasses or contact lenses	5.7	6.6	15.7	4.0	0.6	-2.7	2.7	1.5
Ever taken oral contraceptive pill	0.7	0.8	3.3	0.8	-0.3	-0.0	1.8	0.2
Hearing aid user	0.9	1.0	3.8	-0.0	2.0	-0.4	0.5	0.9
Mother’s age at death	0.4	0.5	1.3	0.4	-0.7	1.2	-0.6	-0.2
Financial situation satisfaction	0.6	0.8	1.3	-0.5	-1.0	0.8	1.1	-0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.2	-0.2	1.1	-0.2	0.4	1.5
Commuting to job workplace: Public transport	0.1	0.1	0.5	-0.7	0.2	-0.3	0.1	-0.3
Eye problems/disorders: Glaucoma	1.4	1.6	5.4	-2.3	1.2	0.5	-0.7	0.7
Medication: Blood pressure	0.9	1.7	4.5	1.0	-1.7	-0.3	2.1	0.1
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.2	-0.8	1.8	-0.8	1.1	1.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	-0.1	-1.2	1.0	-1.1	-0.6
High cholesterol (Self-reported)	1.6	2.9	9.2	1.6	-1.2	-0.5	3.0	0.7
Medication: Bendroflumethiazide	0.5	0.8	2.2	0.4	-1.3	-0.0	1.5	-0.1
Medication: Paracetamol	0.3	0.5	1.4	-1.2	-0.8	0.2	0.5	-0.4
Medication: Lisinopril	1.3	1.7	3.1	1.2	-0.2	-1.3	1.5	1.8
Medication: Atorvastatin	1.2	1.5	4.6	1.4	-0.3	-0.4	2.2	0.9
Illnesses of father: High blood pressure	1.4	1.7	2.5	1.4	0.5	-1.6	1.5	1.2
Alcohol drinker status: Never	0.2	0.2	1.1	1.0	-0.2	-0.3	-0.1	0.0
Ever smoked	1.8	3.1	6.5	0.9	-2.5	1.2	2.5	-0.7
Basal metabolic rate	0.5	2.7	3.9	-1.6	-2.0	1.9	1.6	-0.8
Leg fat percentage (left)	2.5	8.9	17.1	-1.9	-4.1	4.1	0.0	-2.6
Arm fat-free mass (left)	0.5	2.5	3.6	-1.6	-1.8	1.7	1.9	-0.5
Number of operations (self-reported)	0.4	0.7	2.0	-0.4	-1.4	0.7	0.6	-0.4
Average weekly beer plus cider intake	0.7	1.1	2.0	-1.4	-0.6	1.2	-0.8	-0.9
Irritability	0.5	0.9	2.7	0.6	-1.6	1.0	0.7	0.4
Risk taking	0.9	1.4	3.2	-0.4	-1.3	1.1	-0.9	-1.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	0.3	-1.1	0.5	-1.0	-0.8
Fractured/broken bones in last 5 years	1.3	1.7	4.7	0.2	-2.2	0.4	1.4	-1.2
Age started oral contraceptive pill	0.2	0.2	0.8	-0.1	-0.9	0.5	0.1	0.0
Diastolic blood pressure, automated reading	0.4	1.2	3.0	-1.1	1.7	-0.2	-1.3	-0.0
Ever depressed for a whole week	0.6	0.8	1.1	1.1	0.8	-0.9	0.9	0.6
Unable to work because of sickness or disability	0.2	0.2	0.5	0.6	-0.2	-0.4	0.7	0.1
Commuting to job workplace: Cycle	1.0	1.2	3.3	-0.6	-0.9	1.8	-0.0	-1.3
Myopia	2.0	2.9	5.1	0.9	2.2	-1.9	1.6	1.5
Vascular/heart problems diagnosed by doctor	1.1	3.0	12.0	-1.0	0.9	0.7	-3.5	-0.6
Cholesterol lowering medication	1.4	2.1	5.1	2.3	-1.1	-0.8	1.8	0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.6	0.3	-0.7	0.4	0.3
Pain experienced in last month	0.2	0.3	0.9	-0.1	0.3	0.2	-0.9	0.6
Supplements: Calcium	1.6	1.8	4.6	1.0	0.0	-0.8	2.1	1.7
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.2	0.5	0.1	0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.0	-0.2	0.1	-1.2	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.0	-1.0	-0.8	1.1	-1.4	-1.2
Heart disease (siblings)	0.2	0.2	0.6	0.8	-0.4	-0.3	0.4	-0.0
Alcohol drinker status: Previous	0.8	0.9	1.6	1.3	-0.2	-1.2	0.7	0.9
Pack years of smoking	1.0	1.5	3.8	0.6	0.6	-1.2	1.9	1.2
Impedance of whole body	0.2	1.1	2.7	1.3	0.8	-1.6	-0.0	-0.6
Leg fat mass (left)	2.0	7.8	15.1	-2.3	-3.8	3.9	0.4	-2.1
Arm predicted mass (left)	0.5	2.7	4.2	-2.0	-1.7	1.9	1.6	-0.6