Hub : Genes

CHAC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0353	0.0176	0.0036	-0.001	0.010	0.013	0.013	0.005	0.5500	0.00920	0.00360	0.00440	0.04900
2	YFS	Blood	0.0214	0.0087	0.0011	0.004	0.010	0.008	0.011	0.008	0.0160	0.00016	0.00110	0.00012	0.00092
3	TCGA	Cervical Squamous Cell Carcinoma	0.1250	0.0580	0.0029	0.037	0.059	0.057	NA	0.049	0.0062	0.00076	0.00085	NA	0.00190
4	TCGA	Testicular Germ Cell Tumors	0.1880	0.0910	0.0017	0.026	0.066	0.025	NA	0.037	0.0420	0.00240	0.04300	NA	0.01900

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.4	2.2	4.3	-0.6	2.1	2.0	0.0
Bipolar Disorder or Schizophrenia	0.5	1.1	1.7	1.0	1.3	0.7	1.1
Depressed Affect (Nagel 2018)	0.3	0.7	1.3	-1.0	1.1	0.4	0.3
Depression (Nagel 2018)	1.0	1.5	2.6	-1.0	1.6	1.5	-0.5
Intelligence (Savage-Jansen 2018)	1.2	3.7	12.3	3.5	-0.7	-1.5	0.1
Neuroticism (Nagel 2018)	0.1	0.2	0.7	0.5	0.8	-0.2	0.2
Schizophrenia (2018)	0.6	1.3	3.0	1.7	-0.0	-0.6	1.3
Schizophrenia vs Biploar Disorder	1.3	1.7	3.2	1.4	-0.3	-1.2	1.8
Worry (Nagel 2018)	0.5	1.1	2.5	1.3	0.3	-0.5	-1.6
Alzheimer’s Disease (in mother)	1.8	2.2	5.5	-0.0	2.3	1.8	0.2
Alzheimer’s Disease (in father)	0.7	0.7	2.7	-0.4	0.1	-0.3	1.6
Alzheimer’s Disease (including proxy)	0.9	1.3	3.0	-0.1	1.7	1.0	1.0
Crohns Disease (2017)	1.9	4.3	10.3	-1.3	3.2	1.9	1.2
Irritable Bowel Disease (IBD)	1.0	2.4	4.9	-1.7	2.2	1.2	0.7
Ulcerative Colitis (UC)	0.2	0.4	0.8	-0.9	0.8	-0.2	-0.6
Major Depression (MDD)	0.4	0.4	0.9	-0.6	0.2	-0.9	0.7
Reaction Time	0.3	0.5	0.8	0.7	-0.3	-0.9	-0.8
Verbal and Numeric Reasoning (VNR)	2.1	5.1	11.6	3.4	-2.1	-2.0	0.4
Breast Cancer	0.2	0.4	0.9	0.8	-0.9	-0.2	0.3
Ovarian Cancer	0.2	0.2	0.7	-0.2	-0.1	-0.8	0.5
Prostate Cancer	0.8	1.1	2.0	-0.6	1.4	1.2	-0.7
Age at First Birth	0.6	0.9	1.3	0.9	0.3	1.1	1.1
Bipolar Disorder (2011)	0.4	0.4	0.8	0.0	0.4	-0.9	0.8
Body Mass Index (BMI) (2010)	1.2	1.6	3.1	1.8	-1.6	-0.8	-0.4
Coronary Artery Disease (CAD)	0.7	0.8	1.7	0.2	-0.0	1.3	-1.2
Crohns Disease (2012)	1.5	2.5	5.9	-1.4	2.4	0.5	1.3
Mean Putamen Volume	0.2	0.2	0.5	-0.4	-0.5	-0.7	0.1
Fasting Glucose	1.2	1.4	2.6	-0.5	-1.6	-1.5	-0.6
HbA1C	0.6	0.7	1.5	1.1	-1.2	-0.0	-0.2
HDL Cholesterol	1.3	2.2	4.7	-2.2	1.6	1.2	-0.4
LDL Cholesterol	1.1	1.7	3.5	-1.0	1.5	1.9	-0.1
Lupus	0.4	0.5	1.3	-1.1	0.8	0.4	0.3
Neuroticism (2016)	0.9	1.4	4.5	2.1	0.7	0.1	-0.6
Primary Biliary Cirrhosis	1.1	1.6	3.7	-1.5	0.6	-0.4	1.9
Rheumatoid Arthritis	1.4	1.9	2.5	-1.5	1.6	1.1	1.2
Schizophrenia (2014)	1.4	3.0	5.7	2.3	-0.1	-1.1	2.4
Triglycerides	0.4	0.7	2.6	1.6	-0.3	0.2	0.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.7	0.9	-1.0	-1.3	-0.1
Ulcerative Colitis	0.1	0.2	0.3	-0.5	0.6	0.2	-0.1
Blood Eosinophil Count	0.2	1.8	3.7	1.9	0.9	1.5	0.9
Blood Platelet Count	0.6	7.4	15.0	-0.0	3.5	3.9	-1.6
Blood Red Count	0.2	1.7	3.6	-1.2	-1.0	-0.9	-1.9
Blood White Count	0.6	4.7	10.1	0.7	2.8	3.2	0.2
Heel T-Score	2.1	16.7	50.7	0.2	-1.2	3.8	-7.1
BMI	1.3	7.7	16.0	4.0	-1.5	-3.5	0.1
Height	0.3	5.0	12.6	2.4	1.2	3.5	0.2
Waist Hip Ratio (WHR)	0.0	0.2	0.7	0.1	0.0	0.2	0.8
Systolic Blood Pressure	0.9	4.7	10.0	-1.4	3.2	1.9	1.8
Smoking Status	2.1	5.0	8.2	2.5	-0.5	-2.3	2.9
Allergy or Eczema	0.5	1.3	2.5	1.2	1.0	1.6	0.5
Cardiovascular Disease	1.0	3.4	9.2	0.3	1.3	-1.7	3.0
Hypothyroidism (self reported)	0.2	0.5	1.7	0.4	0.2	-0.4	1.3
Respiratory disease	0.6	1.3	4.0	2.0	-0.2	0.2	1.1
Type 2 Diabetes (T2D) (2018)	0.9	1.6	5.0	2.2	0.0	-1.3	0.1
Lung FEV1/FVC ratio	1.0	4.9	10.2	-3.2	2.2	-0.2	2.1
Lung FVC	0.6	3.0	6.7	-2.1	-0.1	0.9	-2.6
Neuroticism	0.2	0.4	0.8	0.9	0.1	-0.2	-0.8
Chronotype (morning person)	1.9	4.4	12.2	-3.5	1.8	-0.6	1.4
Hair Pigment	0.0	0.3	0.8	-0.5	0.2	0.9	0.6
Tanning	0.1	1.3	2.0	-1.4	1.4	0.9	-0.5
Hand grip strength (left)	1.0	2.5	5.1	-2.3	1.4	1.4	-1.0
Number of treatments/medications taken	1.3	2.4	4.4	-0.9	2.1	1.6	1.3
Average weekly spirits intake	1.8	2.2	4.5	1.2	-0.8	-1.5	-2.1
Sensitivity / hurt feelings	0.1	0.2	0.9	1.0	-0.1	0.1	-0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.4	0.7	0.1	-1.0
Hearing difficulty/problems: Yes	0.3	0.5	1.2	-1.1	0.8	0.1	0.3
Relative age of first facial hair	0.2	0.4	1.5	-0.0	0.4	-0.0	1.2
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	4.5	-2.1	1.7	-1.1	2.0
Ever used hormone-replacement therapy (HRT)	0.4	0.4	1.0	-1.0	-0.5	-0.2	-0.7
Ever had hysterectomy (womb removed)	0.6	0.6	1.3	-0.9	0.5	1.2	-0.4
Systolic blood pressure, automated reading	0.8	2.3	5.0	-0.9	2.2	1.2	1.4
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	5.4	-1.6	1.3	-1.6	2.3
Angina	1.2	1.5	3.6	-0.4	1.9	1.5	0.4
Medication for hormone replacement therapy	0.7	0.8	1.4	-0.9	-0.7	0.7	-1.2
Vitamin and mineral supplements	0.4	0.6	1.0	-1.0	0.7	0.1	0.9
Supplements: Zinc	0.9	1.0	1.8	-0.3	1.1	1.4	-0.8
Medication: Co-codamol	1.8	2.1	3.9	-0.2	2.0	1.5	1.5
Medication: Metformin	0.1	0.2	0.4	-0.0	0.5	0.6	0.2
Diabetes (father)	0.3	0.4	1.3	0.0	-1.2	-0.0	-0.3
Diabetes (mother)	0.6	0.7	1.6	-1.3	0.8	0.8	-0.1
Severe depression (siblings)	1.6	1.7	5.1	0.4	-2.3	-0.8	-1.0
Pack years adult smoking proportion	0.3	0.5	1.0	0.1	1.0	0.4	0.9
Impedance of leg (right)	0.1	0.3	1.1	-0.0	-0.1	-0.0	1.0
Leg fat-free mass (left)	0.2	1.1	3.9	2.0	0.2	0.4	-0.5
Trunk fat percentage	0.9	3.7	9.9	3.1	-0.8	-1.8	1.0
Hand grip strength (right)	2.1	5.6	8.6	-2.4	2.9	2.9	-0.2
Townsend deprivation index at recruitment	3.0	4.2	14.8	3.9	-0.8	-1.1	-0.1
Current tobacco smoking	1.1	1.8	4.0	1.2	0.6	-1.0	2.0
Average weekly fortified wine intake	0.4	0.5	1.6	-0.2	-0.3	-1.2	-0.5
Maternal smoking around birth	0.0	0.0	0.1	-0.3	0.2	-0.2	0.0
Fed-up feelings	0.2	0.3	1.1	0.1	1.0	0.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.5	-1.0	1.2	0.6	-1.0
Relative age voice broke	0.1	0.1	0.4	0.0	0.4	0.2	0.6
Taking other prescription medications	1.2	1.9	4.3	-0.5	1.4	2.1	1.0
Age when periods started (menarche)	0.5	1.1	4.0	-2.0	-0.0	0.5	0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.1	0.1	0.7	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	10.8	-1.1	0.7	3.3	-1.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	1.0	-0.5	-0.6	-0.3
Qualifications: CSEs or equivalent	0.2	0.2	0.6	0.2	-0.5	0.2	-0.8
Serious illness, injury or assault to yourself	2.0	2.5	5.3	-2.3	0.5	-1.8	1.1
High blood pressure	1.7	4.7	11.8	-0.7	2.2	-1.3	3.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.3	1.8	0.1	0.6	-0.2
Multivitamins +/- minerals	0.5	0.6	1.8	0.6	-0.6	0.0	-1.3
Stomach or abdominal pain in last month	0.7	0.9	3.3	1.8	0.2	-0.5	-0.3
Supplements: Glucosamine	0.8	1.0	1.9	-0.2	-1.4	-1.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	3.1	0.7	0.1	-1.8	0.0
Medication: Atenolol	0.2	0.3	0.8	-0.1	0.0	0.9	-0.5
Medication: Levothyroxine sodium	0.5	0.8	2.5	0.5	-0.0	-1.6	0.8
Sitting height	0.3	1.9	4.4	1.4	1.1	2.1	-0.2
Chronic bronchitis/emphysema (father)	0.4	0.5	1.3	-0.3	0.7	0.4	1.1
High blood pressure (mother)	0.2	0.3	0.8	0.0	0.9	-0.5	0.2
Body mass index (BMI)	0.8	3.3	6.6	2.6	-0.8	-2.4	0.3
Impedance of leg (left)	0.0	0.2	0.5	-0.1	-0.1	0.3	0.7
Leg predicted mass (left)	0.2	1.1	4.0	2.0	0.3	0.5	-0.5
Trunk fat mass	0.8	3.6	11.6	3.4	-0.6	-1.3	0.7
Waist circumference	1.0	3.6	8.2	2.9	-1.0	-2.2	0.6
Number of incorrect matches in round	0.4	0.7	2.7	-1.6	-0.3	0.0	0.0
Past tobacco smoking	1.9	3.5	5.9	-2.4	1.1	1.9	-1.8
Alcohol usually taken with meals	1.0	1.6	3.7	-1.9	0.8	-1.3	0.6
Nervous feelings	0.8	1.5	4.6	2.1	-0.4	-0.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.7	-0.6	-0.8	-1.6	0.8
Hearing difficulty/problems with background noise	0.3	0.5	1.3	-0.3	0.7	-1.1	-0.1
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-0.1	0.7	-0.5	1.1
Had menopause	0.7	0.9	1.3	1.1	-0.4	-1.1	0.9
Had other major operations	0.3	0.3	0.6	0.3	0.7	0.8	-0.3
Forced vital capacity (FVC)	0.5	1.9	4.9	-0.3	0.2	1.6	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	7.0	-0.0	0.1	2.6	-1.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.2	-1.5	1.1	0.0	0.8
Qualifications: None of the above	0.2	0.5	0.9	0.6	-0.0	0.7	-0.9
Financial difficulties in last 2 years	1.5	2.1	3.8	1.2	-1.7	-1.9	-0.5
Mouth/teeth dental problems	0.3	0.5	1.0	0.4	-0.2	-1.0	0.9
Heart attack	0.1	0.2	0.5	0.2	-0.2	0.3	-0.7
Allergy	0.5	1.1	4.2	-2.1	0.4	-0.3	-0.1
Pain all over the body in last month	0.6	0.6	2.2	-0.4	0.0	-0.3	-1.5
Diabetes (self-reported)	0.9	1.3	2.9	1.5	-0.2	0.4	-1.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.4	-0.8	0.9	-0.0
Medication: Ramipril	1.2	1.5	2.7	-1.6	1.6	-0.2	0.8
Medication: Simvastatin	0.9	1.4	3.1	0.2	1.4	0.5	1.8
Fluid intelligence score	1.2	2.5	8.9	3.0	-0.9	-0.4	0.6
Illnesses of siblings	1.3	1.8	3.2	1.1	-1.8	-0.1	-1.7
Neuroticism score	0.2	0.3	0.9	0.9	0.1	-0.5	-0.4
Weight	0.6	3.0	10.1	3.2	-0.2	-1.3	0.6
Impedance of arm (right)	0.2	1.0	2.0	0.5	0.2	1.4	1.4
Arm fat percentage (right)	0.9	3.4	8.4	2.9	-0.8	-1.8	1.1
Trunk fat-free mass	0.1	0.8	2.2	1.5	0.7	0.8	-0.2
Hip circumference	0.6	2.4	6.9	2.6	-0.6	-1.6	0.1
Time employed in main current job	1.8	2.1	2.7	-1.4	1.4	1.6	1.4
Alcohol intake versus 10 years previously	0.8	1.2	4.4	2.1	0.3	0.5	0.4
Father’s age at death	0.3	0.4	1.0	1.0	-0.5	-0.2	-0.5
Worrier / anxious feelings	0.3	0.5	1.1	0.8	0.6	1.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.2	-0.7	1.1	-0.0	0.1
Falls in the last year	0.6	0.8	1.3	0.1	0.8	-1.1	1.1
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	-1.0	0.0	-0.9	-0.4
Number of live births	1.9	2.7	8.0	1.1	-2.8	-1.2	0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	2.5	-1.1	0.9	1.6	-1.6
Pulse rate	1.1	1.8	6.2	-0.8	-0.0	-0.6	-2.5
Happiness	3.2	3.9	5.8	-2.2	2.4	0.3	2.2
Noisy workplace	0.2	0.3	0.3	-0.5	0.6	-0.5	-0.5
Qualifications: A levels/AS levels or equivalent	0.9	2.1	3.4	-1.0	1.8	0.8	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.4	-0.8	0.4	-1.3	1.6
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	0.5	0.2	1.4	-0.8
Asthma	0.9	1.7	3.5	1.9	-0.6	-1.1	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	-0.5	0.2	-0.8	0.6
Medication: Cholesterol lowering	0.4	0.6	1.2	0.3	0.9	1.1	0.6
Depression (self-reported)	0.1	0.1	0.4	0.6	0.2	-0.2	0.1
Medication: Lansoprazole	0.2	0.3	0.5	-0.1	-0.2	-0.7	0.7
Prospective memory result	1.8	2.2	4.6	0.4	1.6	1.3	2.1
Lung cancer (father)	0.7	0.9	1.7	1.3	-0.1	-0.4	1.2
Illnesses of mother	0.3	0.4	0.7	-0.3	-0.9	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.0	-0.9	0.7	1.4	-2.0
Pulse wave Arterial Stiffness index	1.7	2.0	4.0	2.0	-1.2	-1.5	-0.7
Impedance of arm (left)	0.1	0.4	1.1	0.1	-0.3	0.7	1.1
Arm fat mass (right)	0.8	3.3	9.1	3.0	-0.7	-1.8	0.7
Trunk predicted mass	0.1	0.9	2.4	1.5	0.6	0.8	-0.3
Standing height	0.2	2.1	4.5	1.6	1.0	2.1	0.7
Length of working week for main job	0.8	0.8	1.6	0.7	-1.3	-0.6	0.9
Exposure to tobacco smoke at home	0.7	0.8	1.3	-0.5	-1.2	-1.0	0.7
Breastfed as a baby	0.8	1.0	2.5	-0.1	-1.2	-1.6	-0.1
Tense / ‘highly strung’	1.9	3.2	4.0	1.9	-1.5	-2.0	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.5	-0.5	-0.8	0.2
Hair/balding pattern: Pattern 4	1.0	2.4	7.7	1.0	-0.8	0.7	-2.8
Birth weight of first child	0.9	1.6	3.2	-1.3	-0.4	-1.8	1.2
Peak expiratory flow (PEF)	0.2	0.4	0.9	-0.3	-0.1	0.7	-0.9
Pulse wave reflection index	0.1	0.1	0.4	0.3	-0.1	-0.2	0.6
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.2	-2.0	1.5	-0.0	0.8
Loud music exposure frequency	2.1	2.3	3.5	1.1	-1.4	-1.9	1.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.9	-0.4	0.3	0.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.5	-1.0	1.6	0.6	-0.4
Blood clot in the leg (DVT)	0.6	0.8	1.3	1.0	-0.9	-0.2	-1.1
Medication: Paracetamol	1.4	2.4	4.8	2.2	0.2	-2.1	0.5
Headache pain in last month	0.6	1.1	2.3	1.0	0.4	-1.0	1.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.7	0.5	-1.6	-0.1	-1.3
Glaucoma (self-reported)	2.5	3.0	7.3	-1.8	1.1	0.6	-2.7
Gout (self-reported)	0.2	0.3	0.5	-0.6	0.7	0.4	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.1	0.3	0.5	-0.2	1.5
Medication: Amlodipine	1.4	1.9	3.8	-0.9	1.7	-0.0	1.9
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.3	0.6	-0.4	1.5	-1.3
Birth weight	0.4	1.0	2.2	0.9	-0.4	0.8	-1.5
Chronic bronchitis/emphysema (mother)	1.4	1.6	5.2	-0.2	0.6	-0.8	2.3
High blood pressure (siblings)	0.8	1.2	1.6	-1.3	1.2	-0.5	1.2
Forced vital capacity (FVC), Best measure	0.5	1.7	4.9	-0.2	-0.0	1.3	-2.2
Body fat percentage	0.9	3.6	8.8	3.0	-0.7	-1.9	1.2
Leg fat percentage (right)	1.1	4.1	7.5	2.6	-0.9	-2.7	1.3
Arm fat-free mass (right)	0.1	0.6	1.9	1.4	0.3	0.2	-0.4
Exposure to tobacco smoke outside home	1.3	1.8	4.3	2.1	-0.9	-1.4	0.2
Comparative body size at age 10	0.4	1.2	1.9	1.0	-1.4	-1.3	-0.0
Number of full brothers	0.5	0.6	1.7	1.3	-0.7	-0.6	-0.2
Worry too long after embarrassment	0.5	0.9	1.9	-0.4	0.7	-1.0	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.1	-0.1	0.2	0.3
Wheeze or whistling in the chest in last year	0.5	0.9	2.2	0.9	0.2	0.6	1.5
Number of children fathered	0.5	0.6	2.1	-0.5	-1.4	-0.1	0.2
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.8	8.8	-3.0	1.4	1.6	1.4
Age at first live birth	0.2	0.4	0.7	-0.3	-0.8	-0.6	-0.6
Pulse wave peak to peak time	2.2	2.5	4.3	-2.1	1.5	1.7	0.9
Health satisfaction	3.5	4.5	7.2	-2.7	2.3	-0.6	2.2
Shortness of breath walking on level ground	0.6	0.7	1.2	-0.8	0.7	1.1	-0.6
Qualifications: College or University degree	0.6	1.8	4.5	-1.1	0.9	-0.9	2.1
Eye problems/disorders: None of the above	0.6	0.7	1.8	1.3	-0.0	0.8	-0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.0	-0.1	0.7	0.2	1.0
Emphysema/chronic bronchitis	0.6	0.7	1.9	1.4	-0.6	-0.3	0.5
Medication for pain relief, constipation, heartburn	1.2	2.0	4.5	-0.6	-0.7	2.1	-1.6
Neck or shoulder pain in last month	0.6	0.9	2.4	-0.8	0.7	1.5	0.3
Medication: Blood pressure	2.1	3.7	8.2	-1.5	2.9	-0.4	2.1
Angina (self-reported)	1.0	1.3	3.2	-0.5	1.8	1.2	0.6
Migraine (self-reported)	0.7	0.8	1.3	0.6	1.1	1.0	0.7
Medication: Ibuprofen	0.2	0.3	0.6	-0.4	0.2	-0.8	0.5
Medication: Allopurinol	0.2	0.3	0.5	-0.1	0.6	0.3	0.7
Medication: Omeprazole	2.2	2.7	5.2	-2.3	2.2	-0.1	0.9
Medication: Seretide 50 evohaler	1.1	1.2	3.5	1.9	-0.5	0.6	-0.8
Mean time to correctly identify matches	0.2	0.4	0.9	0.8	-0.3	-0.9	-0.2
Heart disease (mother)	0.2	0.2	0.5	0.7	0.5	0.5	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.5	0.1	0.5	0.3	1.6
Whole body fat mass	0.8	3.5	10.4	3.2	-0.7	-1.6	0.7
Leg fat mass (right)	0.7	2.8	7.5	2.7	-0.4	-1.8	0.6
Arm predicted mass (right)	0.1	0.6	2.0	1.4	0.2	0.0	-0.5
Pulse rate, automated reading	0.9	2.9	5.4	-2.3	-0.4	-2.0	-1.5
Alcohol intake frequency.	0.6	1.4	2.7	-1.4	0.8	1.6	0.5
Comparative height size at age 10	0.4	2.4	5.6	2.4	0.7	1.5	1.1
Number of full sisters	0.9	1.1	2.6	1.6	-0.6	1.2	-0.1
Suffer from ‘nerves’	0.9	1.4	4.7	2.2	0.2	-0.6	-0.6
Overall health rating	1.5	3.3	5.3	-2.3	2.2	0.4	1.6
Chest pain or discomfort	1.3	1.9	3.9	-0.9	1.7	-0.4	2.0
Had major operations	0.1	0.1	0.3	0.1	0.5	0.4	0.3
Age at last live birth	0.1	0.2	0.6	-0.1	-0.8	0.2	0.1
Family relationship satisfaction	3.1	3.8	6.4	-2.5	2.4	0.5	1.7
Leg pain on walking	0.3	0.4	1.5	0.1	0.0	-0.3	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	6.0	-1.1	2.4	0.3	1.3
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.8	-0.5	-0.3	-1.3	-0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.4	0.6	-0.2	1.5	-1.5
Medication: Aspirin	0.3	0.3	0.8	0.4	-0.1	-0.7	0.9
Supplements: Vitamin C	0.6	0.7	2.0	1.4	-0.7	-0.5	0.0
Knee pain experienced in last month	2.8	4.4	7.4	2.2	-2.7	-2.3	0.3
Hypertension (Self-reported)	2.2	6.1	14.9	-0.9	2.7	-1.1	3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.5	-1.2	0.7	0.0	1.2
Illnesses of father: Heart disease	0.5	0.7	1.3	-1.1	-0.6	-0.7	-0.8
Illnesses of siblings: Diabetes	0.1	0.2	0.3	0.0	0.6	0.6	-0.0
Smoking status: Previous	2.4	3.5	6.2	2.5	-1.6	-2.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.3	0.3	0.8	2.1	0.3
Whole body fat-free mass	0.2	0.9	2.7	1.6	0.6	0.7	-0.4
Leg fat-free mass (right)	0.2	1.1	3.6	1.9	0.2	0.6	-0.6
Arm fat percentage (left)	0.8	3.2	7.2	2.7	-0.9	-2.0	0.8
Average weekly red wine intake	0.2	0.4	0.8	-0.7	-0.2	-0.3	0.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.5	-0.3	0.6	-0.9	1.2
Mood swings	0.1	0.1	0.3	0.1	0.3	-0.5	-0.1
Loneliness, isolation	0.3	0.4	0.8	-0.9	-0.8	-0.3	-0.3
Long-standing illness, disability or infirmity	1.1	1.7	2.8	-1.6	1.1	-0.1	1.7
Ever had bowel cancer screening	1.1	1.3	2.1	1.5	1.0	1.3	-0.6
Diabetes diagnosed by doctor	0.4	0.7	1.8	0.9	0.2	-0.0	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.0	-1.4	-0.3	0.7	0.7
Friendships satisfaction	1.6	1.9	4.2	-1.3	1.3	0.1	2.0
Qualifications: nursing, teaching	0.9	1.4	3.7	-0.8	-0.8	-0.9	1.9
Commuting to job workplace: Walk	0.6	0.6	1.8	0.3	0.2	1.3	-0.9
Eye problems/disorders: Cataract	0.3	0.3	0.8	-0.9	0.4	-0.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.5	-0.5	-0.3	0.8
Medication for cholesterol	0.0	0.1	0.2	0.1	-0.4	0.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.1	-0.6	1.1	0.8	-0.2
Back pain experienced in last month	0.6	0.8	1.9	1.1	0.0	1.4	0.6
Mineral and other dietary supplements	1.2	1.6	3.9	-2.0	1.1	-0.3	1.0
Breast cancer (self-reported)	0.5	0.6	0.8	-0.8	0.8	0.9	-0.7
Asthma (self-reported)	1.1	2.1	5.3	2.3	-0.7	-1.1	1.2
Osteoporosis (self-reported)	0.8	1.0	1.7	-1.3	0.7	-1.0	0.8
Osteoarthritis (self-reported)	1.1	1.5	2.4	1.0	-1.5	-1.6	0.1
Medication: Aspirin	0.2	0.2	0.6	0.2	0.1	-0.5	0.8
Medication: Gliclazide	0.3	0.3	0.6	0.7	-0.4	0.6	-0.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	1.3	0.2	-0.5	-0.2
Smoking status: Current	1.0	1.6	3.2	1.4	0.7	-0.9	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	7.4	0.4	-0.4	-0.0	-2.7
Whole body water mass	0.2	1.0	2.8	1.7	0.6	0.7	-0.4
Leg predicted mass (right)	0.2	1.1	3.7	1.9	0.2	0.6	-0.6
Arm fat mass (left)	0.8	3.2	9.2	3.0	-0.7	-1.7	0.6
Number of self-reported non-cancer illnesses	0.6	1.1	3.1	-0.1	1.1	0.1	1.8
Average weekly champagne plus white wine intake	2.2	3.0	4.7	-2.0	1.3	-1.4	2.2
Miserableness	0.4	0.6	1.4	-0.2	0.7	-1.2	0.8
Guilty feelings	1.7	2.6	7.7	2.8	-1.2	0.7	-0.8
Wears glasses or contact lenses	3.3	3.8	9.4	-1.3	1.9	0.9	3.1
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.6	0.0	0.7	-0.0
Hearing aid user	1.2	1.4	3.5	-1.9	1.3	0.3	0.3
Mother’s age at death	0.7	0.9	1.7	-0.3	-1.3	-1.2	0.6
Financial situation satisfaction	0.7	0.8	1.7	0.6	-0.3	-1.1	1.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	-0.4	-0.4	0.9	-0.4
Commuting to job workplace: Public transport	0.9	1.0	3.2	-0.8	1.8	-0.5	0.3
Eye problems/disorders: Glaucoma	0.5	0.6	1.3	-0.7	0.5	-0.6	-1.2
Medication: Blood pressure	0.6	1.1	3.4	0.7	0.8	-0.4	1.8
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.4	0.1	1.0	1.5	-0.7
Supplements: Fish oil (including cod liver oil)	1.2	1.5	4.5	2.1	-0.5	0.8	-0.9
High cholesterol (Self-reported)	0.9	1.6	4.2	0.4	1.5	0.1	2.0
Medication: Bendroflumethiazide	0.7	1.1	1.9	0.5	1.4	-0.4	1.4
Medication: Paracetamol	0.7	1.0	2.4	0.8	1.6	-1.0	0.2
Medication: Lisinopril	1.5	1.9	4.8	-0.9	2.2	0.4	1.3
Medication: Atorvastatin	0.7	0.9	2.3	0.2	0.9	1.5	0.5
Illnesses of father: High blood pressure	1.1	1.4	3.4	-0.2	1.5	1.9	0.1
Alcohol drinker status: Never	0.1	0.2	0.3	-0.0	-0.5	0.5	0.3
Ever smoked	1.8	3.2	5.3	2.0	-0.8	-1.7	2.3
Basal metabolic rate	0.2	1.2	4.6	2.1	0.3	0.2	-0.1
Leg fat percentage (left)	1.1	3.9	7.1	2.7	-0.8	-2.5	1.1
Arm fat-free mass (left)	0.2	1.0	3.5	1.9	0.4	0.3	-0.2
Number of operations (self-reported)	0.2	0.3	1.0	1.0	0.5	0.1	-0.1
Average weekly beer plus cider intake	1.6	2.3	4.8	2.2	-1.8	0.3	-1.0
Irritability	0.2	0.3	0.5	0.6	0.7	0.1	-0.4
Risk taking	0.2	0.3	0.8	0.1	-0.4	-0.9	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	0.2	-0.8	-0.7	-0.2
Fractured/broken bones in last 5 years	1.6	2.0	4.8	0.1	-0.2	-1.8	2.2
Age started oral contraceptive pill	0.2	0.2	0.4	0.6	-0.3	0.6	-0.2
Diastolic blood pressure, automated reading	0.3	1.0	3.4	-1.8	0.8	0.4	0.0
Ever depressed for a whole week	0.5	0.6	1.1	-1.0	0.5	-0.3	1.0
Unable to work because of sickness or disability	0.1	0.1	0.5	-0.0	-0.1	-0.1	0.7
Commuting to job workplace: Cycle	1.3	1.6	2.7	1.6	-1.6	-1.1	-0.2
Myopia	1.8	2.6	3.7	-1.6	1.9	1.7	1.1
Vascular/heart problems diagnosed by doctor	1.3	3.6	9.1	0.4	-2.0	1.1	-3.0
Cholesterol lowering medication	1.2	1.8	5.3	0.1	1.3	0.1	2.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.0	-1.7	1.7	-0.3	1.0
Pain experienced in last month	0.5	0.9	2.6	-0.8	0.3	0.6	-1.6
Supplements: Calcium	0.8	0.9	2.1	0.4	0.7	1.5	0.9
Basal cell carcinoma (self-reported)	0.5	0.5	1.3	-0.6	0.7	-1.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.2	0.1	0.4	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	1.6	1.3	-1.2	-0.6	-1.2
Heart disease (siblings)	0.7	0.9	2.8	-0.1	1.7	0.6	0.5
Alcohol drinker status: Previous	1.8	2.0	3.1	-1.8	1.4	0.7	1.7
Pack years of smoking	0.6	0.9	2.1	-0.2	1.5	0.8	0.9
Impedance of whole body	0.1	0.4	1.3	-0.3	-0.2	0.3	1.1
Leg fat mass (left)	0.8	3.0	8.8	3.0	-0.6	-1.7	0.3
Arm predicted mass (left)	0.2	1.1	3.9	2.0	0.1	0.3	-0.5