Hub : Genes

CHAC2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0353 0.0176 0.0036 -0.001 0.010 0.013 0.013 0.005 0.5500 0.00920 0.00360 0.00440 0.04900
2 YFS Blood 0.0214 0.0087 0.0011 0.004 0.010 0.008 0.011 0.008 0.0160 0.00016 0.00110 0.00012 0.00092
3 TCGA Cervical Squamous Cell Carcinoma 0.1250 0.0580 0.0029 0.037 0.059 0.057 NA 0.049 0.0062 0.00076 0.00085 NA 0.00190
4 TCGA Testicular Germ Cell Tumors 0.1880 0.0910 0.0017 0.026 0.066 0.025 NA 0.037 0.0420 0.00240 0.04300 NA 0.01900

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.4 2.2 4.3 -0.6 2.1 2.0 0.0
Bipolar Disorder or Schizophrenia 0.5 1.1 1.7 1.0 1.3 0.7 1.1
Depressed Affect (Nagel 2018) 0.3 0.7 1.3 -1.0 1.1 0.4 0.3
Depression (Nagel 2018) 1.0 1.5 2.6 -1.0 1.6 1.5 -0.5
Intelligence (Savage-Jansen 2018) 1.2 3.7 12.3 3.5 -0.7 -1.5 0.1
Neuroticism (Nagel 2018) 0.1 0.2 0.7 0.5 0.8 -0.2 0.2
Schizophrenia (2018) 0.6 1.3 3.0 1.7 -0.0 -0.6 1.3
Schizophrenia vs Biploar Disorder 1.3 1.7 3.2 1.4 -0.3 -1.2 1.8
Worry (Nagel 2018) 0.5 1.1 2.5 1.3 0.3 -0.5 -1.6
Alzheimer’s Disease (in mother) 1.8 2.2 5.5 -0.0 2.3 1.8 0.2
Alzheimer’s Disease (in father) 0.7 0.7 2.7 -0.4 0.1 -0.3 1.6
Alzheimer’s Disease (including proxy) 0.9 1.3 3.0 -0.1 1.7 1.0 1.0
Crohns Disease (2017) 1.9 4.3 10.3 -1.3 3.2 1.9 1.2
Irritable Bowel Disease (IBD) 1.0 2.4 4.9 -1.7 2.2 1.2 0.7
Ulcerative Colitis (UC) 0.2 0.4 0.8 -0.9 0.8 -0.2 -0.6
Major Depression (MDD) 0.4 0.4 0.9 -0.6 0.2 -0.9 0.7
Reaction Time 0.3 0.5 0.8 0.7 -0.3 -0.9 -0.8
Verbal and Numeric Reasoning (VNR) 2.1 5.1 11.6 3.4 -2.1 -2.0 0.4
Breast Cancer 0.2 0.4 0.9 0.8 -0.9 -0.2 0.3
Ovarian Cancer 0.2 0.2 0.7 -0.2 -0.1 -0.8 0.5
Prostate Cancer 0.8 1.1 2.0 -0.6 1.4 1.2 -0.7
Age at First Birth 0.6 0.9 1.3 0.9 0.3 1.1 1.1
Bipolar Disorder (2011) 0.4 0.4 0.8 0.0 0.4 -0.9 0.8
Body Mass Index (BMI) (2010) 1.2 1.6 3.1 1.8 -1.6 -0.8 -0.4
Coronary Artery Disease (CAD) 0.7 0.8 1.7 0.2 -0.0 1.3 -1.2
Crohns Disease (2012) 1.5 2.5 5.9 -1.4 2.4 0.5 1.3
Mean Putamen Volume 0.2 0.2 0.5 -0.4 -0.5 -0.7 0.1
Fasting Glucose 1.2 1.4 2.6 -0.5 -1.6 -1.5 -0.6
HbA1C 0.6 0.7 1.5 1.1 -1.2 -0.0 -0.2
HDL Cholesterol 1.3 2.2 4.7 -2.2 1.6 1.2 -0.4
LDL Cholesterol 1.1 1.7 3.5 -1.0 1.5 1.9 -0.1
Lupus 0.4 0.5 1.3 -1.1 0.8 0.4 0.3
Neuroticism (2016) 0.9 1.4 4.5 2.1 0.7 0.1 -0.6
Primary Biliary Cirrhosis 1.1 1.6 3.7 -1.5 0.6 -0.4 1.9
Rheumatoid Arthritis 1.4 1.9 2.5 -1.5 1.6 1.1 1.2
Schizophrenia (2014) 1.4 3.0 5.7 2.3 -0.1 -1.1 2.4
Triglycerides 0.4 0.7 2.6 1.6 -0.3 0.2 0.4
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.7 0.9 -1.0 -1.3 -0.1
Ulcerative Colitis 0.1 0.2 0.3 -0.5 0.6 0.2 -0.1
Blood Eosinophil Count 0.2 1.8 3.7 1.9 0.9 1.5 0.9
Blood Platelet Count 0.6 7.4 15.0 -0.0 3.5 3.9 -1.6
Blood Red Count 0.2 1.7 3.6 -1.2 -1.0 -0.9 -1.9
Blood White Count 0.6 4.7 10.1 0.7 2.8 3.2 0.2
Heel T-Score 2.1 16.7 50.7 0.2 -1.2 3.8 -7.1
BMI 1.3 7.7 16.0 4.0 -1.5 -3.5 0.1
Height 0.3 5.0 12.6 2.4 1.2 3.5 0.2
Waist Hip Ratio (WHR) 0.0 0.2 0.7 0.1 0.0 0.2 0.8
Systolic Blood Pressure 0.9 4.7 10.0 -1.4 3.2 1.9 1.8
Smoking Status 2.1 5.0 8.2 2.5 -0.5 -2.3 2.9
Allergy or Eczema 0.5 1.3 2.5 1.2 1.0 1.6 0.5
Cardiovascular Disease 1.0 3.4 9.2 0.3 1.3 -1.7 3.0
Hypothyroidism (self reported) 0.2 0.5 1.7 0.4 0.2 -0.4 1.3
Respiratory disease 0.6 1.3 4.0 2.0 -0.2 0.2 1.1
Type 2 Diabetes (T2D) (2018) 0.9 1.6 5.0 2.2 0.0 -1.3 0.1
Lung FEV1/FVC ratio 1.0 4.9 10.2 -3.2 2.2 -0.2 2.1
Lung FVC 0.6 3.0 6.7 -2.1 -0.1 0.9 -2.6
Neuroticism 0.2 0.4 0.8 0.9 0.1 -0.2 -0.8
Chronotype (morning person) 1.9 4.4 12.2 -3.5 1.8 -0.6 1.4
Hair Pigment 0.0 0.3 0.8 -0.5 0.2 0.9 0.6
Tanning 0.1 1.3 2.0 -1.4 1.4 0.9 -0.5
Hand grip strength (left) 1.0 2.5 5.1 -2.3 1.4 1.4 -1.0
Number of treatments/medications taken 1.3 2.4 4.4 -0.9 2.1 1.6 1.3
Average weekly spirits intake 1.8 2.2 4.5 1.2 -0.8 -1.5 -2.1
Sensitivity / hurt feelings 0.1 0.2 0.9 1.0 -0.1 0.1 -0.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.1 -0.4 0.7 0.1 -1.0
Hearing difficulty/problems: Yes 0.3 0.5 1.2 -1.1 0.8 0.1 0.3
Relative age of first facial hair 0.2 0.4 1.5 -0.0 0.4 -0.0 1.2
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 4.5 -2.1 1.7 -1.1 2.0
Ever used hormone-replacement therapy (HRT) 0.4 0.4 1.0 -1.0 -0.5 -0.2 -0.7
Ever had hysterectomy (womb removed) 0.6 0.6 1.3 -0.9 0.5 1.2 -0.4
Systolic blood pressure, automated reading 0.8 2.3 5.0 -0.9 2.2 1.2 1.4
Eye problems/disorders: Diabetes related eye disease 2.8 3.1 5.4 -1.6 1.3 -1.6 2.3
Angina 1.2 1.5 3.6 -0.4 1.9 1.5 0.4
Medication for hormone replacement therapy 0.7 0.8 1.4 -0.9 -0.7 0.7 -1.2
Vitamin and mineral supplements 0.4 0.6 1.0 -1.0 0.7 0.1 0.9
Supplements: Zinc 0.9 1.0 1.8 -0.3 1.1 1.4 -0.8
Medication: Co-codamol 1.8 2.1 3.9 -0.2 2.0 1.5 1.5
Medication: Metformin 0.1 0.2 0.4 -0.0 0.5 0.6 0.2
Diabetes (father) 0.3 0.4 1.3 0.0 -1.2 -0.0 -0.3
Diabetes (mother) 0.6 0.7 1.6 -1.3 0.8 0.8 -0.1
Severe depression (siblings) 1.6 1.7 5.1 0.4 -2.3 -0.8 -1.0
Pack years adult smoking proportion 0.3 0.5 1.0 0.1 1.0 0.4 0.9
Impedance of leg (right) 0.1 0.3 1.1 -0.0 -0.1 -0.0 1.0
Leg fat-free mass (left) 0.2 1.1 3.9 2.0 0.2 0.4 -0.5
Trunk fat percentage 0.9 3.7 9.9 3.1 -0.8 -1.8 1.0
Hand grip strength (right) 2.1 5.6 8.6 -2.4 2.9 2.9 -0.2
Townsend deprivation index at recruitment 3.0 4.2 14.8 3.9 -0.8 -1.1 -0.1
Current tobacco smoking 1.1 1.8 4.0 1.2 0.6 -1.0 2.0
Average weekly fortified wine intake 0.4 0.5 1.6 -0.2 -0.3 -1.2 -0.5
Maternal smoking around birth 0.0 0.0 0.1 -0.3 0.2 -0.2 0.0
Fed-up feelings 0.2 0.3 1.1 0.1 1.0 0.4 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 1.5 -1.0 1.2 0.6 -1.0
Relative age voice broke 0.1 0.1 0.4 0.0 0.4 0.2 0.6
Taking other prescription medications 1.2 1.9 4.3 -0.5 1.4 2.1 1.0
Age when periods started (menarche) 0.5 1.1 4.0 -2.0 -0.0 0.5 0.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.6 0.1 0.1 0.7 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.6 3.7 10.8 -1.1 0.7 3.3 -1.5
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.1 1.0 -0.5 -0.6 -0.3
Qualifications: CSEs or equivalent 0.2 0.2 0.6 0.2 -0.5 0.2 -0.8
Serious illness, injury or assault to yourself 2.0 2.5 5.3 -2.3 0.5 -1.8 1.1
High blood pressure 1.7 4.7 11.8 -0.7 2.2 -1.3 3.4
Hayfever, allergic rhinitis or eczema 0.4 0.9 3.3 1.8 0.1 0.6 -0.2
Multivitamins +/- minerals 0.5 0.6 1.8 0.6 -0.6 0.0 -1.3
Stomach or abdominal pain in last month 0.7 0.9 3.3 1.8 0.2 -0.5 -0.3
Supplements: Glucosamine 0.8 1.0 1.9 -0.2 -1.4 -1.1 -0.9
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 3.1 0.7 0.1 -1.8 0.0
Medication: Atenolol 0.2 0.3 0.8 -0.1 0.0 0.9 -0.5
Medication: Levothyroxine sodium 0.5 0.8 2.5 0.5 -0.0 -1.6 0.8
Sitting height 0.3 1.9 4.4 1.4 1.1 2.1 -0.2
Chronic bronchitis/emphysema (father) 0.4 0.5 1.3 -0.3 0.7 0.4 1.1
High blood pressure (mother) 0.2 0.3 0.8 0.0 0.9 -0.5 0.2
Body mass index (BMI) 0.8 3.3 6.6 2.6 -0.8 -2.4 0.3
Impedance of leg (left) 0.0 0.2 0.5 -0.1 -0.1 0.3 0.7
Leg predicted mass (left) 0.2 1.1 4.0 2.0 0.3 0.5 -0.5
Trunk fat mass 0.8 3.6 11.6 3.4 -0.6 -1.3 0.7
Waist circumference 1.0 3.6 8.2 2.9 -1.0 -2.2 0.6
Number of incorrect matches in round 0.4 0.7 2.7 -1.6 -0.3 0.0 0.0
Past tobacco smoking 1.9 3.5 5.9 -2.4 1.1 1.9 -1.8
Alcohol usually taken with meals 1.0 1.6 3.7 -1.9 0.8 -1.3 0.6
Nervous feelings 0.8 1.5 4.6 2.1 -0.4 -0.5 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.7 -0.6 -0.8 -1.6 0.8
Hearing difficulty/problems with background noise 0.3 0.5 1.3 -0.3 0.7 -1.1 -0.1
Hair/balding pattern: Pattern 2 0.4 0.5 1.2 -0.1 0.7 -0.5 1.1
Had menopause 0.7 0.9 1.3 1.1 -0.4 -1.1 0.9
Had other major operations 0.3 0.3 0.6 0.3 0.7 0.8 -0.3
Forced vital capacity (FVC) 0.5 1.9 4.9 -0.3 0.2 1.6 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 7.0 -0.0 0.1 2.6 -1.4
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.2 -1.5 1.1 0.0 0.8
Qualifications: None of the above 0.2 0.5 0.9 0.6 -0.0 0.7 -0.9
Financial difficulties in last 2 years 1.5 2.1 3.8 1.2 -1.7 -1.9 -0.5
Mouth/teeth dental problems 0.3 0.5 1.0 0.4 -0.2 -1.0 0.9
Heart attack 0.1 0.2 0.5 0.2 -0.2 0.3 -0.7
Allergy 0.5 1.1 4.2 -2.1 0.4 -0.3 -0.1
Pain all over the body in last month 0.6 0.6 2.2 -0.4 0.0 -0.3 -1.5
Diabetes (self-reported) 0.9 1.3 2.9 1.5 -0.2 0.4 -1.7
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.8 0.4 -0.8 0.9 -0.0
Medication: Ramipril 1.2 1.5 2.7 -1.6 1.6 -0.2 0.8
Medication: Simvastatin 0.9 1.4 3.1 0.2 1.4 0.5 1.8
Fluid intelligence score 1.2 2.5 8.9 3.0 -0.9 -0.4 0.6
Illnesses of siblings 1.3 1.8 3.2 1.1 -1.8 -0.1 -1.7
Neuroticism score 0.2 0.3 0.9 0.9 0.1 -0.5 -0.4
Weight 0.6 3.0 10.1 3.2 -0.2 -1.3 0.6
Impedance of arm (right) 0.2 1.0 2.0 0.5 0.2 1.4 1.4
Arm fat percentage (right) 0.9 3.4 8.4 2.9 -0.8 -1.8 1.1
Trunk fat-free mass 0.1 0.8 2.2 1.5 0.7 0.8 -0.2
Hip circumference 0.6 2.4 6.9 2.6 -0.6 -1.6 0.1
Time employed in main current job 1.8 2.1 2.7 -1.4 1.4 1.6 1.4
Alcohol intake versus 10 years previously 0.8 1.2 4.4 2.1 0.3 0.5 0.4
Father’s age at death 0.3 0.4 1.0 1.0 -0.5 -0.2 -0.5
Worrier / anxious feelings 0.3 0.5 1.1 0.8 0.6 1.1 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.2 -0.7 1.1 -0.0 0.1
Falls in the last year 0.6 0.8 1.3 0.1 0.8 -1.1 1.1
Hair/balding pattern: Pattern 3 0.3 0.5 0.9 -1.0 0.0 -0.9 -0.4
Number of live births 1.9 2.7 8.0 1.1 -2.8 -1.2 0.4
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 2.5 -1.1 0.9 1.6 -1.6
Pulse rate 1.1 1.8 6.2 -0.8 -0.0 -0.6 -2.5
Happiness 3.2 3.9 5.8 -2.2 2.4 0.3 2.2
Noisy workplace 0.2 0.3 0.3 -0.5 0.6 -0.5 -0.5
Qualifications: A levels/AS levels or equivalent 0.9 2.1 3.4 -1.0 1.8 0.8 1.8
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 2.4 -0.8 0.4 -1.3 1.6
Mouth/teeth dental problems: Dentures 0.4 0.7 1.9 0.5 0.2 1.4 -0.8
Asthma 0.9 1.7 3.5 1.9 -0.6 -1.1 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.6 -0.5 0.2 -0.8 0.6
Medication: Cholesterol lowering 0.4 0.6 1.2 0.3 0.9 1.1 0.6
Depression (self-reported) 0.1 0.1 0.4 0.6 0.2 -0.2 0.1
Medication: Lansoprazole 0.2 0.3 0.5 -0.1 -0.2 -0.7 0.7
Prospective memory result 1.8 2.2 4.6 0.4 1.6 1.3 2.1
Lung cancer (father) 0.7 0.9 1.7 1.3 -0.1 -0.4 1.2
Illnesses of mother 0.3 0.4 0.7 -0.3 -0.9 -0.7 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 4.0 -0.9 0.7 1.4 -2.0
Pulse wave Arterial Stiffness index 1.7 2.0 4.0 2.0 -1.2 -1.5 -0.7
Impedance of arm (left) 0.1 0.4 1.1 0.1 -0.3 0.7 1.1
Arm fat mass (right) 0.8 3.3 9.1 3.0 -0.7 -1.8 0.7
Trunk predicted mass 0.1 0.9 2.4 1.5 0.6 0.8 -0.3
Standing height 0.2 2.1 4.5 1.6 1.0 2.1 0.7
Length of working week for main job 0.8 0.8 1.6 0.7 -1.3 -0.6 0.9
Exposure to tobacco smoke at home 0.7 0.8 1.3 -0.5 -1.2 -1.0 0.7
Breastfed as a baby 0.8 1.0 2.5 -0.1 -1.2 -1.6 -0.1
Tense / ‘highly strung’ 1.9 3.2 4.0 1.9 -1.5 -2.0 -1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.7 0.5 -0.5 -0.8 0.2
Hair/balding pattern: Pattern 4 1.0 2.4 7.7 1.0 -0.8 0.7 -2.8
Birth weight of first child 0.9 1.6 3.2 -1.3 -0.4 -1.8 1.2
Peak expiratory flow (PEF) 0.2 0.4 0.9 -0.3 -0.1 0.7 -0.9
Pulse wave reflection index 0.1 0.1 0.4 0.3 -0.1 -0.2 0.6
Ever highly irritable/argumentative for 2 days 1.5 1.8 4.2 -2.0 1.5 -0.0 0.8
Loud music exposure frequency 2.1 2.3 3.5 1.1 -1.4 -1.9 1.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.9 0.9 -0.4 0.3 0.2
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.5 -1.0 1.6 0.6 -0.4
Blood clot in the leg (DVT) 0.6 0.8 1.3 1.0 -0.9 -0.2 -1.1
Medication: Paracetamol 1.4 2.4 4.8 2.2 0.2 -2.1 0.5
Headache pain in last month 0.6 1.1 2.3 1.0 0.4 -1.0 1.5
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 2.7 0.5 -1.6 -0.1 -1.3
Glaucoma (self-reported) 2.5 3.0 7.3 -1.8 1.1 0.6 -2.7
Gout (self-reported) 0.2 0.3 0.5 -0.6 0.7 0.4 0.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.1 0.3 0.5 -0.2 1.5
Medication: Amlodipine 1.4 1.9 3.8 -0.9 1.7 -0.0 1.9
Medication: Ventolin 100micrograms inhaler 0.9 1.1 2.3 0.6 -0.4 1.5 -1.3
Birth weight 0.4 1.0 2.2 0.9 -0.4 0.8 -1.5
Chronic bronchitis/emphysema (mother) 1.4 1.6 5.2 -0.2 0.6 -0.8 2.3
High blood pressure (siblings) 0.8 1.2 1.6 -1.3 1.2 -0.5 1.2
Forced vital capacity (FVC), Best measure 0.5 1.7 4.9 -0.2 -0.0 1.3 -2.2
Body fat percentage 0.9 3.6 8.8 3.0 -0.7 -1.9 1.2
Leg fat percentage (right) 1.1 4.1 7.5 2.6 -0.9 -2.7 1.3
Arm fat-free mass (right) 0.1 0.6 1.9 1.4 0.3 0.2 -0.4
Exposure to tobacco smoke outside home 1.3 1.8 4.3 2.1 -0.9 -1.4 0.2
Comparative body size at age 10 0.4 1.2 1.9 1.0 -1.4 -1.3 -0.0
Number of full brothers 0.5 0.6 1.7 1.3 -0.7 -0.6 -0.2
Worry too long after embarrassment 0.5 0.9 1.9 -0.4 0.7 -1.0 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 0.1 -0.1 0.2 0.3
Wheeze or whistling in the chest in last year 0.5 0.9 2.2 0.9 0.2 0.6 1.5
Number of children fathered 0.5 0.6 2.1 -0.5 -1.4 -0.1 0.2
Reason for reducing amount of alcohol drunk: Health precaution 3.2 3.8 8.8 -3.0 1.4 1.6 1.4
Age at first live birth 0.2 0.4 0.7 -0.3 -0.8 -0.6 -0.6
Pulse wave peak to peak time 2.2 2.5 4.3 -2.1 1.5 1.7 0.9
Health satisfaction 3.5 4.5 7.2 -2.7 2.3 -0.6 2.2
Shortness of breath walking on level ground 0.6 0.7 1.2 -0.8 0.7 1.1 -0.6
Qualifications: College or University degree 0.6 1.8 4.5 -1.1 0.9 -0.9 2.1
Eye problems/disorders: None of the above 0.6 0.7 1.8 1.3 -0.0 0.8 -0.6
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.0 -0.1 0.7 0.2 1.0
Emphysema/chronic bronchitis 0.6 0.7 1.9 1.4 -0.6 -0.3 0.5
Medication for pain relief, constipation, heartburn 1.2 2.0 4.5 -0.6 -0.7 2.1 -1.6
Neck or shoulder pain in last month 0.6 0.9 2.4 -0.8 0.7 1.5 0.3
Medication: Blood pressure 2.1 3.7 8.2 -1.5 2.9 -0.4 2.1
Angina (self-reported) 1.0 1.3 3.2 -0.5 1.8 1.2 0.6
Migraine (self-reported) 0.7 0.8 1.3 0.6 1.1 1.0 0.7
Medication: Ibuprofen 0.2 0.3 0.6 -0.4 0.2 -0.8 0.5
Medication: Allopurinol 0.2 0.3 0.5 -0.1 0.6 0.3 0.7
Medication: Omeprazole 2.2 2.7 5.2 -2.3 2.2 -0.1 0.9
Medication: Seretide 50 evohaler 1.1 1.2 3.5 1.9 -0.5 0.6 -0.8
Mean time to correctly identify matches 0.2 0.4 0.9 0.8 -0.3 -0.9 -0.2
Heart disease (mother) 0.2 0.2 0.5 0.7 0.5 0.5 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.5 0.1 0.5 0.3 1.6
Whole body fat mass 0.8 3.5 10.4 3.2 -0.7 -1.6 0.7
Leg fat mass (right) 0.7 2.8 7.5 2.7 -0.4 -1.8 0.6
Arm predicted mass (right) 0.1 0.6 2.0 1.4 0.2 0.0 -0.5
Pulse rate, automated reading 0.9 2.9 5.4 -2.3 -0.4 -2.0 -1.5
Alcohol intake frequency. 0.6 1.4 2.7 -1.4 0.8 1.6 0.5
Comparative height size at age 10 0.4 2.4 5.6 2.4 0.7 1.5 1.1
Number of full sisters 0.9 1.1 2.6 1.6 -0.6 1.2 -0.1
Suffer from ‘nerves’ 0.9 1.4 4.7 2.2 0.2 -0.6 -0.6
Overall health rating 1.5 3.3 5.3 -2.3 2.2 0.4 1.6
Chest pain or discomfort 1.3 1.9 3.9 -0.9 1.7 -0.4 2.0
Had major operations 0.1 0.1 0.3 0.1 0.5 0.4 0.3
Age at last live birth 0.1 0.2 0.6 -0.1 -0.8 0.2 0.1
Family relationship satisfaction 3.1 3.8 6.4 -2.5 2.4 0.5 1.7
Leg pain on walking 0.3 0.4 1.5 0.1 0.0 -0.3 -1.2
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 6.0 -1.1 2.4 0.3 1.3
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.8 -0.5 -0.3 -1.3 -0.2
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.4 0.6 -0.2 1.5 -1.5
Medication: Aspirin 0.3 0.3 0.8 0.4 -0.1 -0.7 0.9
Supplements: Vitamin C 0.6 0.7 2.0 1.4 -0.7 -0.5 0.0
Knee pain experienced in last month 2.8 4.4 7.4 2.2 -2.7 -2.3 0.3
Hypertension (Self-reported) 2.2 6.1 14.9 -0.9 2.7 -1.1 3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.5 -1.2 0.7 0.0 1.2
Illnesses of father: Heart disease 0.5 0.7 1.3 -1.1 -0.6 -0.7 -0.8
Illnesses of siblings: Diabetes 0.1 0.2 0.3 0.0 0.6 0.6 -0.0
Smoking status: Previous 2.4 3.5 6.2 2.5 -1.6 -2.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 4.3 0.3 0.8 2.1 0.3
Whole body fat-free mass 0.2 0.9 2.7 1.6 0.6 0.7 -0.4
Leg fat-free mass (right) 0.2 1.1 3.6 1.9 0.2 0.6 -0.6
Arm fat percentage (left) 0.8 3.2 7.2 2.7 -0.9 -2.0 0.8
Average weekly red wine intake 0.2 0.4 0.8 -0.7 -0.2 -0.3 0.9
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.5 -0.3 0.6 -0.9 1.2
Mood swings 0.1 0.1 0.3 0.1 0.3 -0.5 -0.1
Loneliness, isolation 0.3 0.4 0.8 -0.9 -0.8 -0.3 -0.3
Long-standing illness, disability or infirmity 1.1 1.7 2.8 -1.6 1.1 -0.1 1.7
Ever had bowel cancer screening 1.1 1.3 2.1 1.5 1.0 1.3 -0.6
Diabetes diagnosed by doctor 0.4 0.7 1.8 0.9 0.2 -0.0 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 2.0 -1.4 -0.3 0.7 0.7
Friendships satisfaction 1.6 1.9 4.2 -1.3 1.3 0.1 2.0
Qualifications: nursing, teaching 0.9 1.4 3.7 -0.8 -0.8 -0.9 1.9
Commuting to job workplace: Walk 0.6 0.6 1.8 0.3 0.2 1.3 -0.9
Eye problems/disorders: Cataract 0.3 0.3 0.8 -0.9 0.4 -0.2 0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 -0.5 -0.5 -0.3 0.8
Medication for cholesterol 0.0 0.1 0.2 0.1 -0.4 0.1 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.1 -0.6 1.1 0.8 -0.2
Back pain experienced in last month 0.6 0.8 1.9 1.1 0.0 1.4 0.6
Mineral and other dietary supplements 1.2 1.6 3.9 -2.0 1.1 -0.3 1.0
Breast cancer (self-reported) 0.5 0.6 0.8 -0.8 0.8 0.9 -0.7
Asthma (self-reported) 1.1 2.1 5.3 2.3 -0.7 -1.1 1.2
Osteoporosis (self-reported) 0.8 1.0 1.7 -1.3 0.7 -1.0 0.8
Osteoarthritis (self-reported) 1.1 1.5 2.4 1.0 -1.5 -1.6 0.1
Medication: Aspirin 0.2 0.2 0.6 0.2 0.1 -0.5 0.8
Medication: Gliclazide 0.3 0.3 0.6 0.7 -0.4 0.6 -0.2
Illnesses of father: None of the above (group 1) 0.4 0.5 1.7 1.3 0.2 -0.5 -0.2
Smoking status: Current 1.0 1.6 3.2 1.4 0.7 -0.9 1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 7.4 0.4 -0.4 -0.0 -2.7
Whole body water mass 0.2 1.0 2.8 1.7 0.6 0.7 -0.4
Leg predicted mass (right) 0.2 1.1 3.7 1.9 0.2 0.6 -0.6
Arm fat mass (left) 0.8 3.2 9.2 3.0 -0.7 -1.7 0.6
Number of self-reported non-cancer illnesses 0.6 1.1 3.1 -0.1 1.1 0.1 1.8
Average weekly champagne plus white wine intake 2.2 3.0 4.7 -2.0 1.3 -1.4 2.2
Miserableness 0.4 0.6 1.4 -0.2 0.7 -1.2 0.8
Guilty feelings 1.7 2.6 7.7 2.8 -1.2 0.7 -0.8
Wears glasses or contact lenses 3.3 3.8 9.4 -1.3 1.9 0.9 3.1
Ever taken oral contraceptive pill 0.2 0.2 0.4 0.6 0.0 0.7 -0.0
Hearing aid user 1.2 1.4 3.5 -1.9 1.3 0.3 0.3
Mother’s age at death 0.7 0.9 1.7 -0.3 -1.3 -1.2 0.6
Financial situation satisfaction 0.7 0.8 1.7 0.6 -0.3 -1.1 1.3
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.8 -0.4 -0.4 0.9 -0.4
Commuting to job workplace: Public transport 0.9 1.0 3.2 -0.8 1.8 -0.5 0.3
Eye problems/disorders: Glaucoma 0.5 0.6 1.3 -0.7 0.5 -0.6 -1.2
Medication: Blood pressure 0.6 1.1 3.4 0.7 0.8 -0.4 1.8
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.4 0.1 1.0 1.5 -0.7
Supplements: Fish oil (including cod liver oil) 1.2 1.5 4.5 2.1 -0.5 0.8 -0.9
High cholesterol (Self-reported) 0.9 1.6 4.2 0.4 1.5 0.1 2.0
Medication: Bendroflumethiazide 0.7 1.1 1.9 0.5 1.4 -0.4 1.4
Medication: Paracetamol 0.7 1.0 2.4 0.8 1.6 -1.0 0.2
Medication: Lisinopril 1.5 1.9 4.8 -0.9 2.2 0.4 1.3
Medication: Atorvastatin 0.7 0.9 2.3 0.2 0.9 1.5 0.5
Illnesses of father: High blood pressure 1.1 1.4 3.4 -0.2 1.5 1.9 0.1
Alcohol drinker status: Never 0.1 0.2 0.3 -0.0 -0.5 0.5 0.3
Ever smoked 1.8 3.2 5.3 2.0 -0.8 -1.7 2.3
Basal metabolic rate 0.2 1.2 4.6 2.1 0.3 0.2 -0.1
Leg fat percentage (left) 1.1 3.9 7.1 2.7 -0.8 -2.5 1.1
Arm fat-free mass (left) 0.2 1.0 3.5 1.9 0.4 0.3 -0.2
Number of operations (self-reported) 0.2 0.3 1.0 1.0 0.5 0.1 -0.1
Average weekly beer plus cider intake 1.6 2.3 4.8 2.2 -1.8 0.3 -1.0
Irritability 0.2 0.3 0.5 0.6 0.7 0.1 -0.4
Risk taking 0.2 0.3 0.8 0.1 -0.4 -0.9 -0.2
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.7 0.2 -0.8 -0.7 -0.2
Fractured/broken bones in last 5 years 1.6 2.0 4.8 0.1 -0.2 -1.8 2.2
Age started oral contraceptive pill 0.2 0.2 0.4 0.6 -0.3 0.6 -0.2
Diastolic blood pressure, automated reading 0.3 1.0 3.4 -1.8 0.8 0.4 0.0
Ever depressed for a whole week 0.5 0.6 1.1 -1.0 0.5 -0.3 1.0
Unable to work because of sickness or disability 0.1 0.1 0.5 -0.0 -0.1 -0.1 0.7
Commuting to job workplace: Cycle 1.3 1.6 2.7 1.6 -1.6 -1.1 -0.2
Myopia 1.8 2.6 3.7 -1.6 1.9 1.7 1.1
Vascular/heart problems diagnosed by doctor 1.3 3.6 9.1 0.4 -2.0 1.1 -3.0
Cholesterol lowering medication 1.2 1.8 5.3 0.1 1.3 0.1 2.3
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 3.0 -1.7 1.7 -0.3 1.0
Pain experienced in last month 0.5 0.9 2.6 -0.8 0.3 0.6 -1.6
Supplements: Calcium 0.8 0.9 2.1 0.4 0.7 1.5 0.9
Basal cell carcinoma (self-reported) 0.5 0.5 1.3 -0.6 0.7 -1.2 -0.1
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.2 0.1 0.4 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 1.6 1.3 -1.2 -0.6 -1.2
Heart disease (siblings) 0.7 0.9 2.8 -0.1 1.7 0.6 0.5
Alcohol drinker status: Previous 1.8 2.0 3.1 -1.8 1.4 0.7 1.7
Pack years of smoking 0.6 0.9 2.1 -0.2 1.5 0.8 0.9
Impedance of whole body 0.1 0.4 1.3 -0.3 -0.2 0.3 1.1
Leg fat mass (left) 0.8 3.0 8.8 3.0 -0.6 -1.7 0.3
Arm predicted mass (left) 0.2 1.1 3.9 2.0 0.1 0.3 -0.5