[Hub]/) : Traits : Hypertension (Self-reported) :

chr11:46,010,847-48,783,497

Best TWAS P=6.3e-24 · Best GWAS P=1.19e-19 conditioned to 8.19e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AGBL2 0.03 0.02 enet 7 0.03 7.9e-05 -8.31 -8.5 2.5e-17 0.70 0.29 0.68 FALSE
2 CommonMind Brain Pre-frontal Cortex ARHGAP1 0.16 0.04 enet 18 0.04 2.3e-05 3.20 5.9 3.8e-09 -0.22 0.67 0.02 FALSE
3 CommonMind Brain Pre-frontal Cortex PTPRJ 0.06 0.04 lasso 4 0.05 7.6e-07 -8.57 -8.0 1.5e-15 0.68 0.18 0.82 FALSE
4 GTEx Adipose Subcutaneous ACP2 0.08 0.03 enet 18 0.03 3.5e-03 -7.57 5.3 9.2e-08 -0.30 0.21 0.42 FALSE
5 GTEx Adipose Subcutaneous PTPRJ 0.05 0.05 lasso 2 0.04 3.9e-04 -4.57 -5.2 2.0e-07 0.80 0.17 0.48 FALSE
6 GTEx Adipose Visceral Omentum ACP2 0.08 0.05 lasso 5 0.05 1.4e-03 -7.74 8.0 1.6e-15 -0.36 0.14 0.66 FALSE
7 GTEx Artery Tibial MADD 0.09 0.00 enet 13 0.02 1.1e-02 7.93 -5.8 8.6e-09 0.26 0.46 0.02 FALSE
8 GTEx Artery Tibial ZNF408 0.10 0.00 lasso 6 0.04 2.0e-04 -2.91 6.5 6.0e-11 -0.19 0.12 0.68 FALSE
9 GTEx Brain Cerebellar Hemisphere MADD 0.44 0.14 lasso 7 0.21 4.0e-06 -7.57 5.9 3.7e-09 -0.24 0.11 0.72 FALSE
10 GTEx Brain Cerebellar Hemisphere ACP2 0.29 0.05 enet 16 0.12 5.9e-04 -6.92 7.0 2.6e-12 -0.31 0.08 0.14 FALSE
11 GTEx Brain Cerebellar Hemisphere RP11-750H9.5 0.17 0.25 lasso 6 0.21 3.5e-06 7.49 -7.5 6.8e-14 0.35 0.44 0.04 FALSE
12 GTEx Brain Hypothalamus NR1H3 0.25 0.18 lasso 5 0.10 2.7e-03 -7.59 -7.7 1.0e-14 0.34 0.14 0.16 FALSE
13 GTEx Brain Putamen basal ganglia CKAP5 0.25 0.07 lasso 3 0.14 4.4e-04 -9.02 -5.6 2.7e-08 0.29 0.02 0.69 FALSE
14 GTEx Breast Mammary Tissue (Female) ACP2 0.03 0.00 lasso 1 0.02 1.0e-01 -8.59 8.6 1.0e-17 -0.60 0.03 0.12 FALSE
15 GTEx Breast Mammary Tissue (Female) PSMC3 0.02 0.01 lasso 1 0.04 2.5e-02 -7.10 7.1 1.2e-12 -0.61 0.03 0.07 FALSE
16 GTEx Cells EBV-transformed lymphocytes ACP2 0.17 0.03 lasso 6 0.03 4.2e-02 -7.15 10.1 6.3e-24 -0.47 0.04 0.87 TRUE
17 GTEx Esophagus Gastroesophageal Junction NUP160 0.18 0.02 enet 18 0.11 7.1e-05 4.23 -7.0 2.1e-12 0.33 0.27 0.07 FALSE
18 GTEx Esophagus Gastroesophageal Junction CKAP5 0.11 0.04 lasso 3 0.03 2.1e-02 -4.42 -5.8 6.2e-09 0.26 0.23 0.24 FALSE
19 GTEx Esophagus Mucosa ACP2 0.07 0.04 enet 11 0.04 6.2e-04 -8.15 8.9 3.8e-19 -0.43 0.02 0.98 FALSE
20 GTEx Esophagus Mucosa C11orf49 0.19 0.05 enet 21 0.12 3.2e-08 -6.67 -6.4 1.2e-10 0.28 0.71 0.12 FALSE
21 GTEx Heart Atrial Appendage ACP2 0.10 0.12 enet 7 0.10 2.7e-05 -7.11 5.4 7.3e-08 -0.26 0.18 0.47 FALSE
22 GTEx Heart Left Ventricle MADD 0.14 0.01 enet 17 0.05 7.0e-04 -8.94 7.9 2.9e-15 -0.43 0.02 0.96 FALSE
23 GTEx Heart Left Ventricle ACP2 0.11 0.06 enet 18 0.10 9.2e-06 -8.94 8.2 3.3e-16 -0.35 0.03 0.96 FALSE
24 GTEx Heart Left Ventricle ARHGAP1 0.06 0.03 lasso 2 0.02 2.1e-02 -5.92 5.6 2.3e-08 -0.24 0.08 0.66 FALSE
25 GTEx Lung ACP2 0.04 0.03 lasso 2 0.04 4.3e-04 -7.01 8.6 1.3e-17 -0.39 0.06 0.89 FALSE
26 GTEx Muscle Skeletal FNBP4 0.05 0.03 lasso 5 0.04 5.0e-05 -8.15 -7.0 1.8e-12 0.39 0.30 0.56 FALSE
27 GTEx Nerve Tibial C11orf49 0.17 0.01 enet 21 0.05 9.5e-05 -8.76 -6.6 4.9e-11 0.33 0.08 0.83 FALSE
28 GTEx Nerve Tibial CELF1 0.08 0.02 enet 15 0.06 4.3e-05 4.58 -5.2 1.6e-07 0.34 0.21 0.04 FALSE
29 GTEx Pancreas LRP4 0.11 0.10 enet 16 0.14 1.8e-06 -4.42 5.7 1.1e-08 -0.26 0.87 0.06 FALSE
30 GTEx Skin Not Sun Exposed Suprapubic DDB2 0.07 0.02 enet 13 0.04 3.5e-03 -7.01 -5.5 4.8e-08 0.25 0.14 0.08 FALSE
31 GTEx Skin Not Sun Exposed Suprapubic SLC39A13 0.07 0.11 lasso 2 0.10 5.2e-06 -8.15 -8.2 2.9e-16 0.55 0.20 0.47 FALSE
32 GTEx Skin Sun Exposed Lower leg ACP2 0.16 0.14 enet 15 0.15 1.8e-12 -7.57 6.2 4.2e-10 -0.30 1.00 0.00 FALSE
33 GTEx Spleen ACP2 0.19 -0.01 lasso 5 0.04 4.1e-02 -6.85 5.4 6.2e-08 -0.29 0.07 0.42 FALSE
34 GTEx Testis NR1H3 0.10 0.10 lasso 6 0.08 2.9e-04 -7.61 7.7 9.6e-15 -0.34 0.17 0.73 FALSE
35 GTEx Thyroid ACP2 0.19 0.14 lasso 4 0.12 3.0e-09 -7.74 7.6 3.7e-14 -0.34 0.82 0.18 FALSE
36 METSIM Adipose NR1H3 0.03 0.03 lasso 6 0.04 4.7e-06 7.99 -9.3 1.4e-20 0.40 0.13 0.82 FALSE
37 METSIM Adipose RAPSN 0.11 0.01 enet 21 0.06 7.9e-09 -4.90 -5.3 9.2e-08 0.36 0.98 0.01 FALSE
38 NTR Blood ACP2 0.01 0.00 enet 7 0.01 2.5e-03 -8.15 7.3 2.2e-13 -0.40 0.01 0.97 FALSE
39 NTR Blood DDB2 0.01 0.00 lasso 7 0.01 2.2e-03 -6.85 8.2 3.3e-16 -0.37 0.07 0.77 FALSE
40 NTR Blood PTPRJ 0.04 0.01 blup 285 0.02 8.5e-08 -4.51 -5.2 2.2e-07 0.35 0.65 0.34 FALSE
41 ROSMAP Brain Pre-frontal Cortex NR1H3 0.06 0.01 blup 302 0.04 1.5e-05 -8.15 -6.7 2.8e-11 0.39 0.18 0.80 FALSE
42 ROSMAP Brain Pre-frontal Cortex PTPMT1 0.03 0.02 blup 270 0.02 3.8e-04 -8.15 -5.5 3.7e-08 0.48 0.08 0.87 FALSE
43 ROSMAP Brain Pre-frontal Cortex LRP4 0.04 0.06 blup 286 0.05 3.5e-07 -6.92 -7.9 2.4e-15 0.36 0.30 0.70 FALSE
44 ROSMAP Brain Pre-frontal Cortex ACP2 0.03 0.00 blup 295 0.02 1.5e-03 -0.91 6.0 2.1e-09 -0.40 0.13 0.70 FALSE
45 ROSMAP Brain Pre-frontal Cortex C11orf49 0.02 0.02 blup 322 0.02 3.3e-04 -4.24 -6.3 2.1e-10 0.31 0.49 0.47 FALSE
46 ROSMAP Brain Pre-frontal Cortex ZNF408 0.04 0.02 blup 243 0.03 5.0e-05 -3.96 5.4 5.3e-08 -0.22 0.12 0.87 FALSE
47 YFS Blood DDB2 0.02 0.00 bslmm 306 0.01 1.9e-04 -8.94 5.3 1.1e-07 -0.30 0.02 0.92 FALSE
48 YFS Blood NR1H3 0.34 0.15 enet 66 0.24 3.1e-76 -7.08 5.3 1.2e-07 -0.18 1.00 0.00 FALSE
49 The Cancer Genome Atlas Breast Invasive Carcinoma ACP2 0.02 0.01 blup 44 0.02 2.7e-04 -7.74 5.6 1.8e-08 -0.26 0.03 0.32 FALSE
50 The Cancer Genome Atlas Breast Invasive Carcinoma C11orf49 0.05 0.00 blup 90 0.02 3.0e-04 -7.39 -6.0 2.2e-09 0.26 0.00 0.98 FALSE
51 The Cancer Genome Atlas Breast Invasive Carcinoma C1QTNF4 0.02 0.01 lasso 5 0.02 2.1e-04 -8.20 -7.0 2.9e-12 0.57 0.00 0.94 FALSE
52 The Cancer Genome Atlas Colon Adenocarcinoma PSMC3 0.09 0.05 blup 39 0.05 1.0e-03 7.49 -6.7 2.9e-11 0.20 0.08 0.12 FALSE
53 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ACP2 0.02 0.03 lasso 1 0.02 1.5e-03 -7.74 7.7 1.0e-14 -0.35 0.04 0.54 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ACP2 0.03 0.03 blup 44 0.04 3.5e-05 -7.61 8.3 8.7e-17 -0.39 0.17 0.79 FALSE
55 The Cancer Genome Atlas Brain Lower Grade Glioma ACP2 0.09 0.04 enet 12 0.06 5.0e-07 -7.57 5.4 7.1e-08 -0.31 0.38 0.61 FALSE
56 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DDB2 0.02 0.03 lasso 1 0.02 1.0e-03 -7.08 -7.1 1.5e-12 0.29 0.12 0.25 FALSE
57 The Cancer Genome Atlas Testicular Germ Cell Tumors MADD 0.21 0.04 blup 64 0.07 1.3e-03 -8.76 6.0 1.7e-09 -0.27 0.01 0.81 FALSE
58 The Cancer Genome Atlas Thyroid Carcinoma DDB2 0.06 0.04 enet 17 0.03 1.3e-03 -8.95 -7.8 5.0e-15 0.39 0.00 1.00 FALSE
59 The Cancer Genome Atlas Thyroid Carcinoma MADD 0.07 0.00 enet 11 0.03 6.7e-04 -8.15 5.7 1.2e-08 -0.26 0.01 0.80 FALSE
60 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma ZNF408 0.27 0.01 blup 27 0.09 1.5e-03 -6.59 5.7 1.0e-08 -0.25 0.00 0.83 FALSE