[Hub]/) : Traits : Forced vital capacity (FVC), Best measure : ← →

chr17:60,821,100-64,251,733

Best TWAS P=1.24e-29 · Best GWAS P=2.48e-25 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	-10.38	11.3	1.2e-29	-0.98	0.00	1.00	TRUE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	-9.56	-9.6	1.1e-21	0.76	0.15	0.13	TRUE
82	The Cancer Genome Atlas	Thyroid Carcinoma	PLEKHM1P	0.04	0.03	blup	7	0.05	1.2e-05	8.28	-8.9	3.9e-19	-0.03	0.01	0.99	TRUE
3	CommonMind	Brain Pre-frontal Cortex	SMARCD2	0.03	0.03	blup	330	0.03	1.1e-04	10.38	8.2	2.4e-16	-0.22	0.04	0.95	TRUE
60	YFS	Blood	SMARCD2	0.03	0.04	lasso	7	0.05	7.6e-15	10.31	7.4	1.7e-13	-0.09	0.09	0.91	TRUE
12	GTEx	Brain Hippocampus	CYB561	0.33	0.24	enet	29	0.27	4.3e-07	-3.34	6.0	2.0e-09	-0.06	0.58	0.05	TRUE
23	GTEx	Cells Transformed fibroblasts	ICAM2	0.17	0.06	lasso	5	0.09	5.6e-07	3.34	-5.9	2.8e-09	0.30	0.94	0.00	TRUE
57	YFS	Blood	AXIN2	0.20	0.05	enet	34	0.10	5.1e-31	5.48	-5.6	2.2e-08	0.01	0.01	0.99	TRUE
27	GTEx	Esophagus Mucosa	CCDC47	0.12	0.00	lasso	5	0.00	3.7e-01	9.96	5.3	1.4e-07	-0.04	0.08	0.25	TRUE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	-10.33	10.3	9.3e-25	-0.98	0.00	0.86	FALSE
50	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	10.31	-10.3	1.2e-24	0.36	0.06	0.94	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCN4A	0.04	0.01	blup	39	0.03	1.4e-07	-10.33	-10.2	3.1e-24	0.75	0.05	0.92	FALSE
38	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	10.08	10.1	6.6e-24	-0.34	0.11	0.89	FALSE
32	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	10.04	10.1	7.3e-24	-0.34	0.11	0.85	FALSE
16	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	10.09	10.1	7.4e-24	-0.36	0.12	0.88	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	10.09	10.1	8.4e-24	-0.35	0.09	0.91	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	10.08	-10.0	1.4e-23	0.32	0.08	0.61	FALSE
48	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	10.08	10.0	1.6e-23	-0.33	0.09	0.81	FALSE
11	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	9.67	10.0	1.9e-23	-0.39	0.13	0.84	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	9.96	-10.0	2.4e-23	0.35	0.11	0.68	FALSE
20	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	9.94	9.9	2.9e-23	-0.35	0.04	0.28	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	10.09	9.9	5.0e-23	-0.48	0.08	0.90	FALSE
56	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	9.75	-9.8	7.4e-23	0.38	0.46	0.53	FALSE
36	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	9.79	9.8	1.1e-22	-0.35	0.11	0.88	FALSE
45	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	10.09	9.7	3.0e-22	-0.33	0.11	0.89	FALSE
6	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	9.91	9.7	3.1e-22	-0.33	0.08	0.92	FALSE
18	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	-9.99	9.6	6.0e-22	-0.70	0.03	0.41	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	9.79	9.3	9.4e-21	-0.26	0.02	0.75	FALSE
31	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	-9.69	-9.3	1.5e-20	0.73	0.46	0.13	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	-9.16	-9.2	5.1e-20	0.74	0.04	0.07	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	10.31	9.1	8.1e-20	-0.25	0.00	1.00	FALSE
59	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	8.85	-9.1	8.5e-20	0.42	0.56	0.44	FALSE
30	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	-9.14	-9.1	1.1e-19	0.74	0.22	0.31	FALSE
7	GTEx	Adipose Visceral Omentum	CD79B	0.15	0.00	lasso	6	0.02	4.1e-02	-10.38	9.0	1.8e-19	-0.90	0.01	0.94	FALSE
42	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	9.94	8.9	5.5e-19	-0.27	0.07	0.50	FALSE
40	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	10.09	8.8	9.7e-19	-0.27	0.07	0.59	FALSE
19	GTEx	Breast Mammary Tissue (Female)	DCAF7	0.10	0.02	lasso	3	0.00	4.4e-01	8.85	8.8	2.2e-18	-0.28	0.06	0.26	FALSE
44	GTEx	Skin Sun Exposed Lower leg	DDX42	0.07	0.04	lasso	4	0.05	2.5e-05	10.31	-8.7	3.0e-18	0.21	0.05	0.94	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLEKHM1P	0.02	0.02	blup	7	0.02	6.7e-03	8.35	-8.6	6.1e-18	-0.02	0.00	0.83	FALSE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	SMARCD2	0.04	0.02	blup	28	0.01	1.6e-02	9.96	8.6	9.0e-18	-0.20	0.00	0.78	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PLEKHM1P	0.24	0.26	lasso	6	0.27	8.0e-33	8.28	-8.5	1.5e-17	-0.03	0.01	0.99	FALSE
46	GTEx	Skin Sun Exposed Lower leg	hsa-mir-6080	0.11	0.10	lasso	2	0.08	1.7e-07	8.19	-8.5	1.6e-17	-0.04	0.02	0.98	FALSE
22	GTEx	Cells Transformed fibroblasts	PSMC5	0.19	0.09	lasso	5	0.10	7.1e-08	-9.16	-8.5	2.1e-17	0.69	0.68	0.30	FALSE
29	GTEx	Esophagus Mucosa	MAP3K3	0.05	0.01	enet	11	0.02	1.8e-02	6.24	8.4	3.7e-17	-0.28	0.06	0.79	FALSE
64	The Cancer Genome Atlas	Glioblastoma Multiforme	PLEKHM1P	0.08	0.04	blup	7	0.04	2.7e-02	8.24	-8.4	5.5e-17	-0.04	0.00	0.46	FALSE
24	GTEx	Cells Transformed fibroblasts	SMURF2	0.17	0.13	enet	8	0.13	3.7e-10	8.15	8.4	5.6e-17	0.04	0.02	0.98	FALSE
28	GTEx	Esophagus Mucosa	DDX42	0.08	0.06	lasso	3	0.09	1.3e-06	10.04	-8.4	5.9e-17	0.18	0.10	0.89	FALSE
14	GTEx	Brain Hypothalamus	DDX42	0.15	0.18	lasso	3	0.09	4.2e-03	10.38	-8.3	7.1e-17	0.20	0.04	0.73	FALSE
39	GTEx	Pancreas	DDX42	0.17	0.18	lasso	3	0.16	3.6e-07	9.94	-8.3	7.1e-17	0.19	0.15	0.84	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	-9.16	8.3	1.5e-16	-0.74	0.03	0.04	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	PLEKHM1P	0.02	0.01	blup	7	0.02	4.7e-03	8.35	-7.9	2.0e-15	-0.02	0.00	0.73	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLEKHM1P	0.08	0.03	enet	4	0.04	4.0e-05	8.28	-7.9	3.1e-15	-0.06	0.01	0.95	FALSE
10	GTEx	Artery Tibial	DDX42	0.13	0.14	lasso	5	0.15	9.1e-12	10.08	-7.8	7.5e-15	0.12	0.09	0.91	FALSE
17	GTEx	Breast Mammary Tissue (Male)	MAP3K3	0.12	0.14	lasso	2	0.07	1.2e-02	9.79	7.8	7.8e-15	-0.12	0.07	0.58	FALSE
8	GTEx	Adipose Visceral Omentum	MAP3K3	0.10	0.04	enet	12	0.05	9.0e-04	10.08	7.7	1.2e-14	-0.33	0.07	0.80	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX42	0.07	0.07	enet	11	0.07	9.2e-08	9.94	-7.7	1.2e-14	0.13	0.04	0.96	FALSE
37	GTEx	Muscle Skeletal	SMARCD2	0.13	0.03	lasso	5	0.04	1.3e-04	-9.18	-7.6	3.0e-14	0.59	0.78	0.08	FALSE
53	METSIM	Adipose	CD79B	0.04	0.01	lasso	5	0.01	4.3e-03	-4.86	7.5	8.5e-14	-0.56	0.04	0.87	FALSE
55	NTR	Blood	LIMD2	0.04	0.03	blup	304	0.03	2.2e-10	9.75	-7.3	2.8e-13	0.41	0.17	0.83	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SCN4A	0.05	0.01	blup	41	0.04	2.2e-05	3.19	-7.2	8.9e-13	0.67	0.08	0.66	FALSE
34	GTEx	Heart Atrial Appendage	CYB561	0.19	0.01	enet	28	0.06	1.3e-03	-1.88	7.1	9.9e-13	-0.28	0.06	0.24	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRADA	0.07	0.01	blup	57	0.03	5.5e-04	2.23	7.1	1.2e-12	-0.71	0.10	0.03	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DDX42	0.04	0.02	blup	51	0.03	3.9e-04	10.31	-6.8	7.3e-12	0.06	0.01	0.97	FALSE
25	GTEx	Colon Sigmoid	CD79B	0.17	0.00	lasso	9	0.08	9.7e-04	9.96	6.7	2.2e-11	-0.22	0.06	0.44	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	PLEKHM1P	0.01	0.01	enet	7	0.01	1.9e-02	8.35	-6.5	7.8e-11	-0.03	0.00	0.81	FALSE
54	METSIM	Adipose	RP11-214C8.2	0.03	0.00	blup	304	0.01	4.2e-03	-3.43	-6.4	1.4e-10	0.48	0.24	0.07	FALSE
47	GTEx	Spleen	FTSJ3	0.19	0.07	lasso	3	0.06	1.2e-02	9.11	6.4	1.5e-10	-0.02	0.22	0.44	FALSE
58	YFS	Blood	ICAM2	0.06	0.03	enet	21	0.04	1.3e-11	3.28	-6.2	4.1e-10	0.35	1.00	0.00	FALSE
52	GTEx	Vagina	SMURF2	0.32	0.00	enet	1	0.06	1.4e-02	6.23	6.2	4.7e-10	0.02	0.03	0.20	FALSE
33	GTEx	Esophagus Muscularis	MAP3K3	0.07	0.02	enet	8	0.02	3.0e-02	9.94	6.2	5.3e-10	-0.03	0.16	0.70	FALSE
49	GTEx	Stomach	DCAF7	0.24	0.00	enet	33	0.08	1.2e-04	1.30	6.2	5.8e-10	-0.18	0.05	0.41	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SMURF2	0.10	0.01	blup	14	0.05	5.5e-03	7.14	6.1	1.0e-09	0.04	0.00	0.80	FALSE
51	GTEx	Testis	CCDC47	0.17	0.06	enet	28	0.09	1.0e-04	-9.56	5.7	1.2e-08	-0.67	0.04	0.93	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	DDX42	0.06	0.04	blup	51	0.06	7.9e-08	-0.28	-5.4	6.0e-08	-0.06	0.08	0.92	FALSE
80	The Cancer Genome Atlas	Stomach Adenocarcinoma	DDX42	0.04	0.02	blup	51	0.04	5.2e-04	9.91	-5.4	6.0e-08	-0.06	0.02	0.79	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	SCN4A	0.04	0.01	blup	41	0.02	5.7e-03	3.19	-5.4	6.2e-08	0.21	0.02	0.03	FALSE
13	GTEx	Brain Hypothalamus	CYB561	0.24	0.22	enet	19	0.08	5.6e-03	-3.39	5.3	9.5e-08	-0.04	0.32	0.07	FALSE
26	GTEx	Colon Transverse	DDX42	0.19	0.07	lasso	4	0.11	4.4e-06	-0.88	-5.3	1.0e-07	-0.03	0.23	0.71	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	ICAM2	0.03	0.03	blup	35	0.02	7.2e-03	-3.90	-5.3	1.2e-07	0.24	0.07	0.12	FALSE
41	GTEx	Pancreas	MILR1	0.18	0.01	lasso	7	0.03	1.3e-02	8.25	5.2	1.5e-07	0.05	0.08	0.06	FALSE
9	GTEx	Artery Aorta	CYB561	0.07	0.04	enet	21	0.06	4.7e-04	-3.31	5.2	1.9e-07	-0.05	0.15	0.08	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TCAM1P	0.05	0.03	enet	8	0.04	4.1e-06	-9.96	5.2	2.1e-07	-0.62	0.70	0.29	FALSE
35	GTEx	Lung	PSMC5	0.04	0.00	enet	5	0.01	4.1e-02	-0.25	-5.2	2.5e-07	0.59	0.34	0.08	FALSE