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chr19:16,462,417-20,451,172

Best TWAS P=5.38e-14 · Best GWAS P=8.92e-14 conditioned to 0.000914

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	GTEx	Esophagus Muscularis	MYO9B	0.13	0.02	lasso	5	0.05	9.5e-04	5.3	-7.5	5.4e-14	-0.02	0.03	0.96	TRUE
100	The Cancer Genome Atlas	Thyroid Carcinoma	HAPLN4	0.08	0.06	blup	37	0.09	1.8e-09	6.7	7.5	6.2e-14	0.85	0.01	0.99	TRUE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA1683	0.16	0.11	lasso	6	0.11	2.9e-12	-6.7	7.4	1.2e-13	-0.03	0.00	1.00	TRUE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ISYNA1	0.05	0.03	enet	8	0.03	2.3e-03	5.0	-5.5	4.2e-08	0.10	0.00	0.82	TRUE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA0892	0.03	0.01	lasso	7	0.02	6.3e-03	7.4	-7.4	1.4e-13	-0.94	0.01	0.85	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GATAD2A	0.13	0.30	lasso	7	0.29	2.4e-35	7.1	-7.3	2.2e-13	-0.97	0.09	0.91	FALSE
87	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA1683	0.09	0.05	lasso	4	0.06	1.3e-07	5.8	7.3	3.2e-13	-0.03	0.00	1.00	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA0892	0.04	0.04	blup	43	0.02	4.1e-03	7.4	-7.2	4.2e-13	-0.95	0.01	0.98	FALSE
26	GTEx	Esophagus Muscularis	KIAA1683	0.10	0.04	lasso	3	0.06	1.1e-04	-6.7	7.2	4.6e-13	-0.02	0.00	0.99	FALSE
13	GTEx	Artery Tibial	CTD-3032J10.3	0.14	0.01	lasso	5	0.01	6.4e-02	7.3	-7.2	5.4e-13	0.04	0.01	0.93	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	GATAD2A	0.04	0.03	blup	61	0.05	1.3e-03	7.0	7.2	7.6e-13	0.93	0.04	0.81	FALSE
56	YFS	Blood	KIAA1683	0.51	0.40	enet	65	0.46	9.9e-171	5.8	7.2	8.3e-13	-0.02	0.30	0.70	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAPLN4	0.05	0.07	lasso	2	0.06	1.1e-07	7.4	7.1	8.8e-13	0.94	0.00	1.00	FALSE
12	GTEx	Artery Tibial	HAUS8	0.16	0.02	lasso	7	0.02	4.7e-03	6.7	-7.1	1.0e-12	-0.01	0.09	0.88	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KIAA1683	0.05	0.04	enet	6	0.05	4.9e-05	-6.7	7.1	1.3e-12	-0.03	0.00	0.99	FALSE
69	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GATAD2A	0.02	0.02	lasso	1	0.02	2.1e-03	7.1	7.1	1.4e-12	0.96	0.03	0.69	FALSE
44	GTEx	Whole Blood	TMEM161A	0.06	0.00	enet	2	0.00	1.4e-01	7.1	-7.1	1.5e-12	-0.97	0.04	0.81	FALSE
18	GTEx	Cells Transformed fibroblasts	KIAA1683	0.14	0.16	lasso	2	0.15	1.2e-11	-6.7	7.1	1.7e-12	-0.03	0.00	1.00	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	HAUS8	0.04	0.06	lasso	2	0.05	2.2e-05	6.7	-7.1	1.7e-12	0.00	0.04	0.95	FALSE
5	GTEx	Adipose Subcutaneous	KIAA1683	0.14	0.09	enet	6	0.16	2.5e-13	-6.7	7.0	2.0e-12	-0.03	0.00	1.00	FALSE
53	YFS	Blood	GATAD2A	0.09	0.14	blup	365	0.14	7.5e-44	7.0	7.0	2.1e-12	0.91	0.12	0.88	FALSE
33	GTEx	Muscle Skeletal	HAUS8	0.15	0.10	lasso	4	0.08	1.6e-08	6.7	-7.0	2.8e-12	-0.01	0.08	0.92	FALSE
66	The Cancer Genome Atlas	Colon Adenocarcinoma	HAPLN4	0.10	0.08	blup	38	0.11	8.5e-07	7.4	7.0	2.8e-12	0.87	0.01	0.99	FALSE
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAPLN4	0.07	0.05	lasso	7	0.07	2.9e-08	5.7	7.0	2.9e-12	0.83	0.03	0.97	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	HAPLN4	0.05	0.03	enet	15	0.03	1.7e-04	5.4	7.0	3.5e-12	0.74	0.35	0.64	FALSE
89	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HAUS8	0.20	0.13	lasso	2	0.11	2.4e-05	6.7	-6.9	4.8e-12	-0.02	0.08	0.84	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAUS8	0.05	0.06	enet	12	0.06	2.9e-12	6.7	-6.9	5.6e-12	0.00	0.08	0.92	FALSE
20	GTEx	Cells Transformed fibroblasts	GATAD2A	0.07	0.00	lasso	4	0.00	8.1e-01	7.1	6.9	5.8e-12	0.83	0.04	0.59	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA1683	0.15	0.09	lasso	6	0.16	5.4e-15	5.9	6.9	5.9e-12	-0.03	0.02	0.98	FALSE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	HAUS8	0.13	0.10	blup	55	0.11	7.8e-12	6.7	-6.9	7.1e-12	0.02	0.09	0.91	FALSE
67	The Cancer Genome Atlas	Colon Adenocarcinoma	HAUS8	0.12	0.06	lasso	5	0.06	1.8e-04	6.7	-6.8	7.7e-12	0.02	0.09	0.84	FALSE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSSK6	0.02	0.02	blup	33	0.02	1.8e-03	7.0	6.8	9.1e-12	0.92	0.01	0.84	FALSE
34	GTEx	Nerve Tibial	KIAA1683	0.25	0.22	lasso	9	0.28	5.2e-20	5.8	6.8	1.0e-11	-0.02	0.15	0.85	FALSE
98	The Cancer Genome Atlas	Stomach Adenocarcinoma	HAUS8	0.06	0.04	blup	55	0.04	1.0e-03	6.7	-6.8	1.0e-11	0.00	0.03	0.54	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	KIAA1683	0.23	0.14	bslmm	409	0.24	1.4e-30	-6.7	6.8	1.2e-11	-0.02	0.00	1.00	FALSE
9	GTEx	Artery Aorta	HAUS8	0.18	0.12	lasso	2	0.09	7.3e-06	6.7	-6.7	1.5e-11	0.00	0.07	0.92	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	HAUS8	0.05	0.05	enet	7	0.05	7.1e-07	6.7	-6.7	1.5e-11	-0.01	0.08	0.92	FALSE
15	GTEx	Brain Cerebellum	SUGP2	0.15	-0.01	enet	27	0.00	2.3e-01	5.4	6.7	2.2e-11	0.68	0.04	0.48	FALSE
36	GTEx	Prostate	KIAA1683	0.20	0.27	lasso	1	0.23	1.8e-06	-6.7	6.7	2.4e-11	-0.03	0.00	0.99	FALSE
40	GTEx	Spleen	KIAA1683	0.26	0.17	lasso	6	0.13	3.9e-04	-6.7	6.7	2.5e-11	-0.04	0.00	0.98	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAUS8	0.08	0.07	blup	55	0.07	6.7e-08	6.7	-6.7	2.6e-11	-0.04	0.09	0.91	FALSE
6	GTEx	Adipose Subcutaneous	HAUS8	0.11	0.09	lasso	3	0.08	5.4e-07	6.7	-6.6	4.8e-11	-0.01	0.08	0.92	FALSE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA1683	0.05	0.03	lasso	4	0.04	9.1e-06	-5.3	6.6	5.1e-11	-0.02	0.03	0.96	FALSE
27	GTEx	Esophagus Muscularis	HAUS8	0.20	0.11	lasso	4	0.09	5.1e-06	6.7	-6.5	5.8e-11	-0.04	0.09	0.89	FALSE
10	GTEx	Artery Tibial	MAU2	0.07	0.05	lasso	4	0.05	1.3e-04	7.2	6.5	6.1e-11	0.88	0.04	0.93	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAPLN4	0.04	0.07	lasso	4	0.06	1.3e-12	5.8	6.5	7.3e-11	0.77	0.96	0.04	FALSE
84	The Cancer Genome Atlas	Lung Adenocarcinoma	HAUS8	0.04	0.04	lasso	2	0.03	1.6e-04	6.7	-6.5	8.0e-11	-0.01	0.08	0.86	FALSE
31	GTEx	Muscle Skeletal	SUGP1	0.11	0.06	lasso	7	0.07	9.5e-08	5.7	-6.5	9.5e-11	-0.81	0.32	0.68	FALSE
75	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAUS8	0.09	0.14	lasso	4	0.12	5.9e-14	6.7	-6.4	1.3e-10	0.00	0.09	0.91	FALSE
99	The Cancer Genome Atlas	Testicular Germ Cell Tumors	KIAA1683	0.17	0.06	blup	65	0.06	3.0e-03	-4.6	6.4	1.3e-10	-0.01	0.01	0.89	FALSE
86	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HAUS8	0.06	0.04	enet	4	0.05	3.9e-06	5.3	-6.4	1.4e-10	-0.03	0.15	0.84	FALSE
14	GTEx	Brain Cerebellar Hemisphere	HAUS8	0.44	0.15	lasso	7	0.11	8.1e-04	6.7	-6.4	1.7e-10	-0.03	0.10	0.66	FALSE
91	The Cancer Genome Atlas	Prostate Adenocarcinoma	GATAD2A	0.04	0.03	lasso	2	0.03	2.9e-04	7.0	6.4	1.8e-10	0.91	0.05	0.87	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	JUND	0.17	0.17	lasso	5	0.20	2.7e-25	5.8	6.4	2.0e-10	-0.02	0.34	0.66	FALSE
3	CommonMind	Brain Pre-frontal Cortex	KIAA1683	0.09	0.06	enet	14	0.10	6.6e-12	-5.3	6.4	2.1e-10	-0.05	0.02	0.98	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	KIAA1683	0.04	0.04	lasso	4	0.05	2.5e-06	-5.3	6.3	2.2e-10	-0.03	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Soft Tissue Sarcoma	HAPLN4	0.11	0.01	blup	38	0.02	2.7e-02	5.7	6.3	2.6e-10	0.78	0.02	0.65	FALSE
59	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	YJEFN3	0.04	0.05	lasso	7	0.04	1.6e-04	5.4	-6.3	3.4e-10	-0.75	0.09	0.73	FALSE
77	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIAA1683	0.09	0.07	lasso	8	0.12	2.1e-13	-6.7	6.3	4.0e-10	-0.04	0.01	0.99	FALSE
79	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	KIAA1683	0.13	0.02	blup	65	0.05	1.0e-03	5.9	6.2	4.1e-10	-0.02	0.02	0.94	FALSE
21	GTEx	Colon Sigmoid	KIAA1683	0.15	0.09	lasso	6	0.09	5.1e-04	-4.0	6.2	4.3e-10	-0.03	0.01	0.97	FALSE
39	GTEx	Spleen	ATP13A1	0.16	0.01	lasso	5	0.02	9.7e-02	7.1	6.2	5.6e-10	0.86	0.05	0.37	FALSE
45	GTEx	Whole Blood	GATAD2A	0.06	0.02	lasso	9	0.03	1.7e-03	7.5	6.2	5.9e-10	0.87	0.03	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HAPLN4	0.07	0.10	lasso	6	0.10	5.3e-12	5.7	6.2	6.6e-10	0.73	0.92	0.08	FALSE
11	GTEx	Artery Tibial	KIAA1683	0.16	0.08	enet	11	0.15	8.2e-12	-6.7	6.1	8.4e-10	-0.02	0.00	1.00	FALSE
24	GTEx	Esophagus Mucosa	AC068499.10	0.16	0.07	lasso	5	0.08	6.7e-06	-5.3	-6.1	8.8e-10	0.05	0.66	0.08	FALSE
64	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HAUS8	0.10	0.07	blup	55	0.07	3.2e-04	6.7	-6.1	8.9e-10	-0.02	0.04	0.92	FALSE
68	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	5.8	6.1	9.0e-10	-0.01	0.02	0.14	FALSE
46	METSIM	Adipose	KIAA1683	0.21	0.24	enet	21	0.27	2.1e-40	-4.9	6.1	1.0e-09	-0.02	0.02	0.98	FALSE
38	GTEx	Skin Sun Exposed Lower leg	KIAA1683	0.09	0.04	enet	9	0.06	1.0e-05	-6.7	6.1	1.1e-09	-0.01	0.01	0.99	FALSE
96	The Cancer Genome Atlas	Soft Tissue Sarcoma	KIAA1683	0.07	0.00	blup	64	0.01	4.5e-02	-3.9	6.0	1.9e-09	-0.01	0.03	0.27	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1683	0.04	0.02	blup	65	0.03	2.6e-07	-6.7	6.0	2.0e-09	-0.03	0.00	1.00	FALSE
28	GTEx	Heart Atrial Appendage	KIAA1683	0.15	0.03	lasso	5	0.10	2.4e-05	5.8	6.0	2.1e-09	0.02	0.01	0.95	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SF4	0.03	0.01	enet	7	0.02	1.1e-03	7.2	6.0	2.3e-09	0.83	0.02	0.93	FALSE
32	GTEx	Muscle Skeletal	MAU2	0.09	0.04	lasso	4	0.05	5.1e-06	3.6	-6.0	2.4e-09	-0.84	0.05	0.95	FALSE
35	GTEx	Pituitary	KIAA1683	0.43	0.25	lasso	3	0.17	3.9e-05	5.9	5.9	2.8e-09	-0.02	0.09	0.56	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	5.8	5.9	3.5e-09	-0.01	0.09	0.52	FALSE
41	GTEx	Stomach	PLVAP	0.27	0.01	lasso	5	0.00	5.0e-01	6.7	5.9	3.7e-09	-0.02	0.04	0.42	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GMIP	0.03	0.02	lasso	4	0.02	3.2e-03	4.4	5.9	4.1e-09	0.69	0.00	0.95	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	KIAA1683	0.16	0.05	enet	12	0.06	3.5e-04	-6.7	5.9	4.8e-09	-0.02	0.01	0.99	FALSE
7	GTEx	Adipose Visceral Omentum	HAUS8	0.15	0.12	lasso	2	0.12	7.0e-07	6.7	-5.8	5.3e-09	0.00	0.08	0.91	FALSE
55	YFS	Blood	HAUS8	0.03	0.02	lasso	6	0.02	3.3e-07	6.0	-5.8	5.4e-09	-0.02	0.14	0.86	FALSE
43	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	5.8	-5.8	5.5e-09	0.01	0.04	0.27	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	5.8	5.8	6.3e-09	-0.01	0.09	0.47	FALSE
88	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	KIAA1683	0.09	0.06	blup	64	0.07	2.2e-05	-6.7	5.7	1.2e-08	-0.03	0.00	1.00	FALSE
19	GTEx	Cells Transformed fibroblasts	HAUS8	0.12	0.05	enet	19	0.05	1.0e-04	6.7	-5.6	2.5e-08	0.00	0.10	0.86	FALSE
29	GTEx	Heart Left Ventricle	KIAA1683	0.20	0.03	lasso	7	0.15	2.9e-08	-4.0	5.6	2.5e-08	0.02	0.10	0.87	FALSE
23	GTEx	Colon Transverse	YJEFN3	0.09	0.09	lasso	3	0.07	4.3e-04	5.1	-5.5	3.3e-08	-0.60	0.29	0.31	FALSE
94	The Cancer Genome Atlas	Prostate Adenocarcinoma	YJEFN3	0.04	0.05	lasso	2	0.05	4.3e-06	5.5	-5.5	4.4e-08	-0.66	0.69	0.14	FALSE
97	The Cancer Genome Atlas	Stomach Adenocarcinoma	HAPLN4	0.08	0.03	blup	37	0.04	7.2e-04	5.7	5.5	4.4e-08	0.52	0.19	0.52	FALSE
22	GTEx	Colon Transverse	KIAA1683	0.15	0.02	lasso	3	0.02	3.3e-02	-4.0	5.5	4.7e-08	-0.02	0.09	0.76	FALSE
30	GTEx	Lung	NR2F6	0.17	0.00	enet	31	0.00	2.5e-01	-1.8	5.5	4.9e-08	0.03	0.06	0.04	FALSE
47	NTR	Blood	GATAD2A	0.02	0.02	blup	386	0.02	1.4e-07	7.2	5.5	5.0e-08	0.90	0.06	0.94	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	CILP2	0.02	0.02	blup	30	0.02	1.6e-04	5.5	5.4	5.7e-08	0.67	0.16	0.22	FALSE
16	GTEx	Breast Mammary Tissue	KIAA1683	0.17	0.10	lasso	5	0.07	1.2e-04	-4.0	5.4	6.5e-08	-0.03	0.02	0.98	FALSE
54	YFS	Blood	GMIP	0.10	0.06	enet	37	0.08	9.6e-24	-4.3	5.4	7.1e-08	0.42	1.00	0.00	FALSE
17	GTEx	Cells Transformed fibroblasts	LPAR2	0.04	0.05	lasso	2	0.04	5.5e-04	4.4	-5.4	7.4e-08	-0.67	0.13	0.53	FALSE
42	GTEx	Thyroid	YJEFN3	0.05	0.02	lasso	3	0.02	1.2e-02	5.6	-5.4	8.0e-08	-0.67	0.18	0.27	FALSE
48	NTR	Blood	LPAR2	0.04	0.03	lasso	3	0.03	3.6e-11	4.4	-5.3	1.1e-07	-0.54	1.00	0.00	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIAA1683	0.06	0.02	blup	65	0.04	3.2e-05	-4.0	5.3	1.3e-07	-0.03	0.01	0.98	FALSE
90	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HAUS8	0.21	0.11	enet	9	0.10	6.2e-05	-5.2	-5.2	2.2e-07	0.06	0.07	0.63	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PDE4C	0.14	0.16	lasso	4	0.15	2.8e-18	-4.8	-5.2	2.3e-07	0.02	0.95	0.05	FALSE
8	GTEx	Adrenal Gland	KIAA1683	0.26	0.05	enet	21	0.19	1.7e-07	-5.0	5.2	2.5e-07	-0.02	0.01	0.98	FALSE