TWAS hub - NR2F6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.3050	0.0490	2.2e-11	0.279	NA	0.267	NA	0.282	7.5e-19	NA	5.5e-18	NA	4.5e-19
2	GTEx	Lung	0.1651	0.0536	9.7e-04	0.000	NA	0.001	NA	-0.003	3.2e-01	NA	2.5e-01	NA	7.3e-01
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1640	0.0560	2.8e-03	0.111	NA	0.059	NA	0.080	1.2e-06	NA	3.8e-04	NA	3.8e-05
4	GTEx	Skin Sun Exposed Lower leg	0.1200	0.0380	3.3e-04	0.150	NA	0.133	NA	0.139	2.1e-12	NA	3.9e-11	NA	1.4e-11
5	YFS	Blood	0.5199	0.0314	0.0e+00	0.186	0.405	0.452	0.456	0.435	1.1e-58	1.6e-144	3.2e-167	5.2e-169	1.6e-158
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0425	0.0271	7.1e-03	0.027	0.017	0.028	NA	0.027	4.5e-04	4.2e-03	3.5e-04	NA	5.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Alcohol intake versus 10 years previously	4.6	6.9	13.4	2.9	1.7	2.7	3.0	-0.9	3.7
Breast cancer (self-reported)	4.5	5.4	8.9	2.8	1.0	3.0	3.0	-0.8	2.2
Ulcerative Colitis	4.3	6.2	9.0	-3.0	-1.8	-2.8	-2.9	0.7	-2.9
Medication: Simvastatin	4.0	5.9	8.0	-2.8	0.6	-2.8	-2.6	2.6	-2.3
Glaucoma (self-reported)	4.0	4.7	7.8	-2.6	-0.7	-2.6	-2.6	-0.0	-2.8
Breastfed as a baby	3.9	4.8	7.8	-2.6	-0.4	-2.8	-2.8	0.3	-2.5
Gout (self-reported)	3.3	4.6	5.7	2.4	2.3	2.3	2.4	0.3	2.4
Illness, injury, bereavement, stress in last 2 years	3.2	3.9	6.9	-2.3	-0.6	-2.2	-2.4	-0.6	-2.6
Angina	3.1	4.1	6.1	-2.4	1.2	-2.5	-2.4	0.1	-2.3
Myopia	3.1	4.5	7.6	-2.0	-2.8	-2.2	-2.2	-1.9	-1.4
Angina (self-reported)	3.0	4.0	5.5	-2.3	1.6	-2.4	-2.2	0.2	-2.3
Ulcerative Colitis (UC)	2.9	5.4	8.6	-2.9	-0.8	-2.6	-2.8	0.7	-2.9
Pulse rate	2.8	4.7	6.4	2.5	2.0	2.5	2.4	-1.6	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.7	3.2	4.5	-2.1	-1.3	-2.0	-2.1	1.2	-1.8
Heart attack	2.6	3.3	4.4	-2.1	1.7	-2.1	-2.1	0.8	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	5.7	2.3	-0.1	2.1	2.1	-0.4	2.4
Suffer from ‘nerves’	2.6	4.1	12.3	-1.6	-3.5	-1.7	-1.7	-1.4	-1.5
Eye problems/disorders: Glaucoma	2.5	2.9	4.0	-1.9	0.2	-1.9	-1.9	1.6	-2.0
Alcohol drinker status: Never	2.5	3.0	4.0	2.0	1.1	1.9	2.0	-1.1	1.9
Hearing difficulty/problems: Yes	2.4	3.7	6.4	2.2	1.2	2.2	2.1	-0.0	2.5
Hearing difficulty/problems with background noise	2.1	3.3	5.1	1.9	2.3	2.1	1.9	0.3	1.9
Depression (self-reported)	2.1	2.5	3.9	2.0	-1.5	1.8	1.8	-0.4	1.5
Irritability	2.1	3.6	5.5	2.4	1.3	2.1	2.1	1.0	2.1
Heart attack/myocardial infarction (self-reported)	2.1	2.7	3.5	-1.8	1.9	-1.8	-1.8	1.0	-1.5
Irritable Bowel Disease (IBD)	2.0	4.6	6.7	-2.6	-1.6	-2.4	-2.5	0.4	-2.5
Body Mass Index (BMI) (2010)	1.9	2.6	4.0	-2.0	-0.7	-2.0	-2.0	1.0	-1.5
Medication: Seretide 50 evohaler	1.9	2.2	3.9	-1.6	-0.2	-1.6	-1.6	-1.0	-2.0
Ever depressed for a whole week	1.9	2.3	3.6	1.7	0.5	1.8	1.9	1.0	1.7
Average weekly beer plus cider intake	1.8	2.6	4.7	1.5	1.0	1.7	1.6	-1.6	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.8	1.1	-2.0	1.1	1.1	-1.5	0.9
Neuroticism (2016)	1.6	2.4	3.1	1.6	1.8	1.7	1.7	0.3	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	5.3	1.3	-2.3	0.9	1.1	-2.2	0.9
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	2.6	1.3	1.2	1.4	1.4	1.6	1.6
Blood clot in the leg (DVT)	1.6	2.1	3.0	1.7	0.4	1.6	1.7	-1.2	1.6
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	2.8	1.6	0.4	1.5	1.6	-1.7	1.4
LDL Cholesterol	1.5	2.3	3.3	-1.8	-1.2	-1.8	-1.8	-0.3	-1.6
Medication: Metformin	1.5	2.1	3.6	-1.8	-0.1	-1.9	-1.7	0.8	-1.6
Diabetes (father)	1.5	1.9	2.9	-1.6	0.2	-1.6	-1.5	1.0	-1.7
Supplements: Glucosamine	1.5	2.0	8.9	-0.5	-3.0	-0.7	-0.6	-1.4	-0.2
Happiness	1.5	1.8	2.6	1.5	1.5	1.5	1.6	0.9	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.6	1.5	-0.4	1.4	1.4	-1.2	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	4.8	1.8	0.5	1.7	1.7	0.3	2.2
Eye problems/disorders: Cataract	1.5	1.7	4.4	-1.3	0.1	-1.4	-1.3	-2.1	-0.6
Medication: Blood pressure	1.5	2.9	12.2	0.8	3.5	1.0	0.9	0.8	1.3
Lupus	1.4	2.1	5.3	-1.4	-2.3	-1.2	-1.3	0.9	-1.1
Rheumatoid Arthritis	1.4	2.0	3.0	1.7	-1.0	1.6	1.6	-0.0	1.7
Supplements: Zinc	1.4	1.5	2.2	1.4	0.5	1.3	1.3	-1.1	1.5
Impedance of leg (right)	1.4	7.0	29.7	1.7	5.5	1.6	1.6	1.8	0.9
Qualifications: A levels/AS levels or equivalent	1.4	3.2	6.0	-1.8	-0.9	-1.9	-1.9	1.1	-2.4
Smoking Status	1.3	3.1	6.7	1.3	-2.1	1.1	1.2	-2.6	1.7
Number of treatments/medications taken	1.3	2.4	4.4	1.4	1.9	1.4	1.4	0.4	2.1
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.9	1.4	0.9	1.3	1.5	-0.2	1.7
Number of live births	1.3	1.8	6.7	1.1	2.6	1.1	1.1	0.3	0.7
Leg predicted mass (right)	1.3	6.7	26.1	-2.0	-5.1	-2.0	-2.0	-0.0	-1.3
Hand grip strength (right)	1.2	3.4	8.6	-1.6	-2.9	-1.5	-1.5	-1.1	-1.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.9	-1.3	-0.9	-1.3	-1.4	-0.4	-1.3
Impedance of leg (left)	1.2	5.7	28.2	1.2	5.3	1.2	1.1	1.3	0.5
Comparative body size at age 10	1.2	3.4	6.0	-1.8	-2.4	-1.8	-1.8	-1.2	-1.7
Wheeze or whistling in the chest in last year	1.2	2.1	3.5	1.8	0.5	1.9	1.8	-0.9	1.4
Health satisfaction	1.2	1.5	5.5	0.7	1.0	0.8	0.8	2.3	0.8
Leg fat-free mass (right)	1.2	6.6	26.0	-2.0	-5.1	-2.0	-2.0	0.0	-1.3
Back pain experienced in last month	1.2	1.8	3.0	-1.2	-1.2	-1.3	-1.3	1.7	-1.0
Medication: Gliclazide	1.2	1.4	2.1	-1.4	1.0	-1.5	-1.4	0.6	-0.8
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.1	1.0	1.2	1.0	0.9	-1.2	2.0
Age started oral contraceptive pill	1.2	1.5	2.1	-1.2	1.1	-1.4	-1.4	0.3	-1.3
HDL Cholesterol	1.1	1.8	3.3	1.5	0.8	1.5	1.6	0.2	1.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.5	-1.6	1.1	-1.6	-1.5	-0.2	-0.7
Severe depression (siblings)	1.1	1.2	2.5	1.3	-0.5	1.2	1.1	-0.6	1.6
Taking other prescription medications	1.1	1.7	3.4	1.3	1.9	1.1	1.2	0.6	1.4
Qualifications: CSEs or equivalent	1.1	1.4	2.7	-1.1	-1.2	-1.3	-1.2	-0.3	-1.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.7	1.3	0.9	1.2	1.3	0.6	1.3
Mood swings	1.1	1.9	2.8	1.5	0.4	1.7	1.6	1.1	1.6
Commuting to job workplace: Walk	1.1	1.1	1.6	1.1	0.8	1.2	1.2	-1.1	0.9
Medication for cholesterol	1.1	1.6	7.5	-0.3	-2.7	-0.4	-0.4	-1.2	-0.6
Schizophrenia (2018)	1.0	2.0	4.6	1.4	-0.1	1.4	1.3	-2.1	1.4
Alzheimer’s Disease (including proxy)	1.0	1.4	4.1	-0.7	-1.4	-0.8	-0.9	-2.0	-0.6
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.4	-1.2	1.1	-1.2	-1.1	1.1	0.0
Medication: Co-codamol	1.0	1.2	3.3	0.6	-1.8	0.4	0.5	-1.6	0.7
Leg fat-free mass (left)	1.0	5.3	21.6	-1.8	-4.6	-1.7	-1.7	0.5	-1.1
Leg predicted mass (left)	1.0	5.4	21.7	-1.8	-4.7	-1.8	-1.7	0.5	-1.1
Hair/balding pattern: Pattern 2	1.0	1.2	2.3	1.3	0.6	1.5	1.4	0.5	0.8
Financial difficulties in last 2 years	1.0	1.3	2.8	1.2	0.4	1.0	1.2	-1.0	1.7
Diabetes (self-reported)	1.0	1.5	2.6	-1.6	0.2	-1.6	-1.5	0.2	-1.2
Illnesses of mother	1.0	1.2	5.3	0.8	-2.3	0.4	0.4	1.1	0.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.8	1.1	1.3	1.1	1.1	0.5	1.3
Exposure to tobacco smoke outside home	1.0	1.4	3.1	1.1	-0.8	1.0	1.2	0.9	1.8
Pulse rate, automated reading	1.0	3.3	5.1	2.1	2.3	2.0	1.9	-1.3	1.1
Illnesses of father: Heart disease	1.0	1.4	1.9	-1.4	-1.2	-1.3	-1.2	0.3	-1.3
Asthma (self-reported)	1.0	2.0	3.5	1.2	1.8	1.4	1.3	-1.9	0.6
Average weekly champagne plus white wine intake	1.0	1.4	5.4	-1.2	-0.0	-0.9	-1.0	-0.2	-2.3
Ever smoked	1.0	1.7	5.3	-0.6	-2.3	-0.7	-0.6	-2.0	-0.4
Hypothyroidism (self reported)	0.9	2.0	3.2	1.6	1.8	1.6	1.6	0.4	0.9
Had other major operations	0.9	1.1	4.7	0.5	-2.2	0.6	0.6	-0.6	0.8
Mouth/teeth dental problems: Dentures	0.9	1.5	2.9	-1.5	-0.4	-1.7	-1.6	-0.4	-1.0
Asthma	0.9	1.8	4.3	1.1	1.5	1.2	1.1	-2.1	0.5
Lung cancer (father)	0.9	1.0	3.8	-0.4	0.5	-0.5	-0.6	-2.0	-1.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.6	-1.0	-1.1	-1.1	-1.1	1.6	-1.0
Medication: Paracetamol	0.9	1.6	2.6	1.1	1.5	1.3	1.1	-0.7	1.6
Medication: Aspirin	0.9	1.2	2.5	-0.8	1.6	-0.9	-0.8	1.5	-0.3
Verbal and Numeric Reasoning (VNR)	0.8	1.8	3.1	1.0	-1.8	1.2	1.0	-1.7	1.3
Age at First Birth	0.8	1.2	6.2	0.1	2.5	0.0	0.1	0.9	-0.2
Current tobacco smoking	0.8	1.3	2.6	0.7	-1.6	0.7	0.7	-1.6	1.1
Maternal smoking around birth	0.8	1.1	2.6	0.7	1.3	0.7	0.8	1.6	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	5.0	0.7	-2.2	0.4	0.5	0.3	0.4
Medication: Levothyroxine sodium	0.8	1.4	2.2	1.4	1.0	1.4	1.5	-0.7	0.8
High blood pressure (mother)	0.8	1.2	6.4	0.2	0.3	0.4	0.4	-2.5	0.5
Weight	0.8	3.9	11.2	-1.8	-3.4	-1.9	-1.8	0.4	-1.4
Hip circumference	0.8	3.5	13.7	-1.4	-3.7	-1.3	-1.4	-0.6	-1.0
Medication: Cholesterol lowering	0.8	1.3	2.5	-1.0	1.6	-1.2	-1.0	1.3	-0.4
Length of working week for main job	0.8	0.9	5.1	0.1	-2.3	-0.1	-0.1	-0.4	-0.4
Arm fat-free mass (right)	0.8	4.0	15.2	-1.6	-3.9	-1.7	-1.6	0.5	-0.7
Arm predicted mass (right)	0.8	4.0	13.7	-1.7	-3.7	-1.8	-1.7	0.5	-1.0
Alcohol intake frequency.	0.8	1.8	3.7	1.5	0.8	1.3	1.6	0.3	1.9
Financial situation satisfaction	0.8	1.0	3.5	0.8	1.9	0.8	0.9	-0.4	0.5
Impedance of whole body	0.8	3.9	19.6	0.5	4.4	0.5	0.4	1.6	-0.6
Ovarian Cancer	0.7	1.0	1.3	-1.0	-1.1	-0.7	-0.8	-1.1	1.1
Mean Putamen Volume	0.7	0.8	3.2	0.1	1.8	0.0	0.1	-1.2	0.2
HbA1C	0.7	0.8	2.4	-0.1	-1.5	-0.2	-0.2	-1.6	-0.2
Blood Red Count	0.7	7.2	10.3	3.0	0.9	3.0	3.2	-3.1	2.0
Hand grip strength (left)	0.7	1.9	3.7	-1.3	-1.9	-1.0	-1.1	-1.5	-1.4
Average weekly spirits intake	0.7	0.9	1.4	1.2	0.7	0.9	1.0	-0.9	0.9
Ever had hysterectomy (womb removed)	0.7	0.7	1.1	1.1	0.8	1.0	1.0	0.6	0.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.6	0.5	-1.6	0.5	0.6	-1.0	0.6
Number of incorrect matches in round	0.7	1.1	3.8	1.0	2.0	0.8	0.9	0.4	0.7
Had menopause	0.7	0.9	1.4	1.0	1.2	0.8	1.0	0.6	1.0
Time employed in main current job	0.7	0.8	2.7	-0.4	1.7	-0.5	-0.5	0.9	-0.7
Medication: Lansoprazole	0.7	0.8	1.3	1.0	0.8	1.0	1.1	0.0	1.0
Tense / ‘highly strung’	0.7	1.2	1.9	1.4	-0.9	1.2	1.3	-0.5	1.0
Birth weight of first child	0.7	1.2	5.0	-0.9	-2.2	-0.7	-0.8	0.0	-0.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.0	1.4	1.3	1.4	1.4	0.2	0.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	-0.9	-1.1	-0.6	-0.7	0.3	-1.4
Medication: Ibuprofen	0.7	0.9	1.8	1.0	0.1	0.9	0.9	-0.9	1.3
Hypertension (Self-reported)	0.7	1.8	5.9	-0.0	2.2	-0.1	0.0	2.4	0.5
Smoking status: Previous	0.7	1.0	3.1	0.9	0.2	0.6	0.8	-1.8	1.0
Whole body fat-free mass	0.7	4.0	17.1	-1.4	-4.1	-1.5	-1.4	0.4	-0.4
Qualifications: nursing, teaching	0.7	1.0	3.0	-0.9	0.4	-0.9	-0.9	1.7	-0.9
Whole body water mass	0.7	4.0	17.0	-1.5	-4.1	-1.5	-1.5	0.4	-0.5
Ever taken oral contraceptive pill	0.7	0.8	1.3	0.9	0.5	1.0	1.1	0.2	1.1
Illnesses of father: High blood pressure	0.7	0.8	2.7	0.7	0.4	0.7	0.7	1.7	0.8
Basal metabolic rate	0.7	3.8	15.9	-1.5	-4.0	-1.5	-1.5	0.5	-0.6
Vascular/heart problems diagnosed by doctor	0.7	2.0	5.9	0.8	-2.4	0.9	0.8	-2.0	0.3
Supplements: Calcium	0.7	0.8	2.0	-0.6	-1.3	-0.7	-0.7	-1.4	-0.3
Prostate Cancer	0.6	0.9	4.5	0.5	-2.1	0.3	0.5	0.0	-0.3
Schizophrenia (2014)	0.6	1.4	6.7	0.5	-0.6	0.5	0.5	-2.6	0.6
BMI	0.6	3.8	8.6	-1.9	-2.9	-1.8	-1.8	0.5	-1.8
Height	0.6	12.1	18.7	-4.3	-0.8	-4.1	-4.3	3.4	-2.6
Lung FVC	0.6	2.9	3.9	-1.9	-1.3	-2.0	-2.0	-1.0	-1.7
Trunk fat percentage	0.6	2.3	4.4	-1.7	-0.9	-1.7	-1.7	0.4	-2.1
High blood pressure	0.6	1.6	4.6	-0.1	2.1	-0.2	-0.1	2.1	0.4
Medication: Atenolol	0.6	0.7	2.0	-0.6	1.4	-0.7	-0.6	1.0	-0.5
Trunk fat mass	0.6	2.7	3.5	-1.8	-1.7	-1.8	-1.8	0.5	-1.9
Pain all over the body in last month	0.6	0.6	3.3	0.2	0.6	0.0	0.1	1.8	-0.4
Hair/balding pattern: Pattern 4	0.6	1.5	2.6	-1.6	-0.6	-1.5	-1.5	0.1	-1.3
High blood pressure (siblings)	0.6	0.9	1.5	-1.2	0.3	-1.1	-1.2	-0.4	-1.0
Worry too long after embarrassment	0.6	1.0	1.5	-1.1	-0.6	-1.0	-1.2	-0.8	-1.0
Comparative height size at age 10	0.6	3.4	6.4	-1.9	0.4	-1.9	-2.0	2.5	-1.5
Had major operations	0.6	0.7	2.1	0.0	-1.4	-0.0	-0.0	-1.4	0.2
Leg pain on walking	0.6	0.8	3.0	0.7	0.3	0.6	0.5	1.7	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.2	-0.4	-1.8	-0.3	-0.5	-0.6	0.0
Diabetes diagnosed by doctor	0.6	1.0	1.6	-1.3	0.1	-1.2	-1.1	0.8	-0.9
Osteoarthritis (self-reported)	0.6	0.7	2.5	0.3	-1.6	0.2	0.2	-1.1	0.8
Medication: Aspirin	0.6	0.8	2.2	-0.7	1.5	-0.8	-0.8	1.0	-0.3
Medication: Paracetamol	0.6	1.0	3.0	0.6	1.7	0.8	0.6	-0.6	1.0
Medication: Atorvastatin	0.6	0.8	1.9	0.8	0.9	0.6	0.7	-1.4	0.8
Diastolic blood pressure, automated reading	0.6	2.0	5.4	1.4	0.8	1.4	1.3	-2.3	0.6
Cholesterol lowering medication	0.6	0.8	2.2	-0.8	1.5	-0.8	-0.7	0.7	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.9	-0.6	-1.4	-0.8	-0.7	-0.7	-0.1
Pain experienced in last month	0.6	1.0	5.7	-0.1	2.4	-0.1	-0.0	-0.5	0.1
Blood Platelet Count	0.5	5.9	9.7	-2.2	1.0	-2.2	-2.3	-3.1	-3.1
Waist Hip Ratio (WHR)	0.5	2.1	9.5	0.7	3.1	0.8	0.7	1.0	0.5
Respiratory disease	0.5	1.2	2.6	0.9	1.4	1.0	0.9	-1.6	0.0
Pack years adult smoking proportion	0.5	0.8	3.9	0.3	-2.0	0.3	0.3	-0.8	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.1	1.1	-1.4	1.3	1.1	-0.5	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.5	0.1	-1.9	-0.0	-0.0	-0.2	0.1
Sitting height	0.5	3.2	6.8	-1.7	-1.1	-1.7	-1.7	2.6	-1.6
Body mass index (BMI)	0.5	2.2	8.9	-1.0	-3.0	-1.0	-0.9	-0.8	-0.8
Alcohol usually taken with meals	0.5	0.9	2.9	-0.6	0.7	-0.5	-0.5	-1.7	-1.1
Nervous feelings	0.5	1.0	1.5	1.2	0.9	0.9	1.0	1.2	0.7
Medication: Ramipril	0.5	0.7	1.0	-1.0	-0.3	-1.0	-1.0	0.3	-0.9
Impedance of arm (right)	0.5	2.5	13.6	0.1	3.7	0.3	0.1	0.9	-0.7
Trunk fat-free mass	0.5	2.8	12.0	-1.1	-3.5	-1.2	-1.2	0.7	0.1
Father’s age at death	0.5	0.7	2.7	0.6	1.6	0.6	0.5	0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.5	0.6	-1.9	0.4	0.5	-0.6	0.3
Impedance of arm (left)	0.5	2.1	8.4	-0.0	2.9	-0.0	-0.1	1.7	-1.2
Trunk predicted mass	0.5	2.6	11.8	-1.1	-3.4	-1.1	-1.1	0.6	0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.5	0.6	-0.8	0.8	0.5	-1.6	-0.4
Number of children fathered	0.5	0.6	1.0	1.0	-0.2	0.9	1.0	0.3	0.5
Shortness of breath walking on level ground	0.5	0.6	0.8	0.8	0.6	0.8	0.8	0.9	0.7
Eye problems/disorders: None of the above	0.5	0.5	1.0	0.8	-0.5	1.0	0.9	0.5	0.5
Neck or shoulder pain in last month	0.5	0.7	2.4	0.6	-1.6	0.6	0.6	-0.5	0.7
Medication: Allopurinol	0.5	0.6	1.7	0.7	1.3	0.6	0.6	0.6	0.7
Mean time to correctly identify matches	0.5	0.9	1.8	0.6	1.1	0.6	0.7	1.3	1.2
Whole body fat mass	0.5	2.0	2.5	-1.6	-1.6	-1.6	-1.5	0.3	-1.5
Knee pain experienced in last month	0.5	0.8	4.3	-0.4	-2.1	-0.5	-0.4	-0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	5.4	-0.1	-2.3	-0.2	-0.2	1.0	0.0
Smoking status: Current	0.5	0.8	2.2	0.5	-1.5	0.5	0.5	-0.9	0.9
Arm fat mass (left)	0.5	2.0	5.7	-1.3	-2.4	-1.3	-1.3	0.0	-1.1
Wears glasses or contact lenses	0.5	0.6	2.6	-0.2	-0.8	-0.5	-0.5	-1.6	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	-0.6	1.2	-0.7	-0.7	0.1	-0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	-0.7	-1.3	-0.7	-0.7	0.5	-0.3
Arm fat-free mass (left)	0.5	2.7	11.3	-1.2	-3.4	-1.3	-1.2	0.4	-0.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.9	-0.7	-0.4	-0.9	-0.8	0.5	-1.0
Heart disease (siblings)	0.5	0.7	3.2	0.1	1.8	-0.0	-0.1	-0.9	0.3
Pack years of smoking	0.5	0.7	2.9	0.2	-1.7	0.2	0.2	-1.1	0.4
Arm predicted mass (left)	0.5	2.4	10.4	-1.2	-3.2	-1.2	-1.2	0.2	-0.2
Bipolar Disorder or Schizophrenia	0.4	0.9	3.3	0.7	-0.3	0.6	0.6	-1.8	0.9
Neuroticism (Nagel 2018)	0.4	1.0	2.1	1.2	0.4	1.2	1.1	-0.1	1.5
Heel T-Score	0.4	2.9	5.3	2.3	0.7	2.2	2.2	-1.1	0.6
Systolic Blood Pressure	0.4	1.8	6.1	0.9	2.5	1.0	0.9	-0.3	1.4
Cardiovascular Disease	0.4	1.4	4.0	-0.8	2.0	-0.9	-0.8	1.4	-0.4
Townsend deprivation index at recruitment	0.4	0.5	1.1	0.7	-1.1	0.5	0.6	-0.8	0.4
Relative age voice broke	0.4	0.6	0.9	0.8	0.9	0.9	0.8	0.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.6	0.3	1.2	0.3	0.3	0.8	-0.1
Multivitamins +/- minerals	0.4	0.5	2.2	0.1	-0.6	0.2	0.1	-1.5	0.6
Past tobacco smoking	0.4	0.7	3.0	0.2	1.1	0.4	0.3	1.7	-0.1
Arm fat mass (right)	0.4	1.7	4.6	-1.3	-2.1	-1.2	-1.2	-0.3	-1.0
Peak expiratory flow (PEF)	0.4	1.0	3.8	-0.6	-1.9	-0.4	-0.5	-0.9	-0.7
Pulse wave reflection index	0.4	0.5	2.1	-0.5	1.4	-0.5	-0.5	0.5	-0.1
Headache pain in last month	0.4	0.6	2.7	0.1	-1.1	0.1	0.1	-1.6	-0.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.3	0.4	-0.9	0.5	0.4	0.4	1.1
Age at first live birth	0.4	0.7	1.5	0.8	1.2	0.7	0.8	0.8	0.2
Qualifications: College or University degree	0.4	1.1	2.1	1.4	0.3	1.5	1.4	-0.4	0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	2.5	-0.7	-0.4	-0.7	-0.6	-0.2	-1.6
Medication: Blood pressure	0.4	0.7	2.7	0.0	0.9	-0.2	-0.0	1.6	0.9
Medication: Omeprazole	0.4	0.4	1.7	-0.3	-0.9	-0.2	-0.2	-1.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.6	-0.6	-0.8	-0.6	-0.6	-0.8	-0.7
Age at last live birth	0.4	0.5	2.4	-0.2	1.6	-0.1	-0.1	0.4	-0.8
Family relationship satisfaction	0.4	0.4	2.0	-0.5	0.1	-0.4	-0.4	1.4	-0.2
Supplements: Vitamin C	0.4	0.5	0.6	0.6	-0.7	0.8	0.7	-0.7	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	-0.7	-0.5	-0.8	-0.9	-0.7	-0.3
Arm fat percentage (left)	0.4	1.7	3.0	-1.3	-1.7	-1.2	-1.2	0.0	-1.6
Friendships satisfaction	0.4	0.5	1.6	-0.5	0.2	-0.4	-0.5	1.3	-0.7
Illnesses of father: None of the above (group 1)	0.4	0.5	0.7	0.7	-0.9	0.7	0.6	-0.8	0.5
Miserableness	0.4	0.7	1.3	0.9	-1.1	0.8	0.8	-0.6	0.9
Mother’s age at death	0.4	0.5	1.2	0.5	0.8	0.6	0.5	-1.1	0.8
Commuting to job workplace: Public transport	0.4	0.4	0.8	0.9	0.4	0.8	0.9	-0.2	0.4
Fractured/broken bones in last 5 years	0.4	0.5	2.0	0.4	1.4	0.5	0.4	-0.5	0.4
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	0.8	0.4	0.8	0.9	0.1	0.4
Depressed Affect (Nagel 2018)	0.3	0.6	1.3	0.9	-0.4	0.9	0.8	-0.3	1.1
Depression (Nagel 2018)	0.3	0.5	2.1	0.5	-1.5	0.3	0.3	0.1	0.6
Intelligence (Savage-Jansen 2018)	0.3	1.1	1.7	1.3	-0.2	1.2	1.1	-0.5	1.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	0.4	0.4	0.5	0.5	1.0	0.9
Alzheimer’s Disease (in father)	0.3	0.4	1.9	0.3	0.1	0.3	0.3	-1.4	0.2
Reaction Time	0.3	0.7	1.0	0.8	0.0	0.9	0.9	1.0	0.9
Breast Cancer	0.3	0.7	1.2	-1.0	1.0	-1.1	-1.0	0.2	0.3
Blood Eosinophil Count	0.3	2.5	14.2	-0.2	-0.5	-0.4	-0.3	-3.8	-0.6
Blood White Count	0.3	2.1	11.6	-0.0	-0.9	0.0	-0.0	-3.4	0.1
Allergy or Eczema	0.3	0.8	1.2	-0.9	-1.0	-0.7	-0.9	0.7	-1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.1	-1.1	-0.2	-0.9	-0.8	0.3	-0.7
Neuroticism	0.3	0.7	1.3	1.1	-0.2	1.0	1.0	-0.3	1.0
Chronotype (morning person)	0.3	0.8	2.8	-0.1	1.7	0.1	0.0	1.2	-0.7
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.3	0.2	-1.5	0.1	0.1	-0.3	0.1
Relative age of first facial hair	0.3	0.6	1.6	0.7	0.4	0.7	0.7	-1.3	0.7
Fed-up feelings	0.3	0.5	1.8	0.3	-1.0	0.2	0.1	-1.3	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.9	-0.7	-1.4	-0.6	-0.7	0.1	-0.9
Waist circumference	0.3	1.0	2.6	-1.1	-1.6	-0.9	-1.0	0.3	-0.7
Allergy	0.3	0.6	1.0	-0.9	-0.2	-1.0	-1.0	1.0	-0.3
Fluid intelligence score	0.3	0.6	2.2	0.2	-1.1	0.1	0.2	-1.5	0.3
Arm fat percentage (right)	0.3	1.0	1.5	-1.1	-1.2	-1.0	-1.0	-0.4	-1.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.7	0.3	1.3	0.1	0.1	-0.8	0.2
Prospective memory result	0.3	0.4	1.3	0.1	0.8	0.1	0.2	1.2	-0.1
Standing height	0.3	3.2	6.6	-1.8	-1.0	-1.8	-1.9	2.6	-1.1
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.5	-0.8	-0.6	-0.5	0.7	-0.0
Loud music exposure frequency	0.3	0.4	1.6	-0.2	0.2	-0.1	-0.2	1.3	0.6
Medication: Amlodipine	0.3	0.5	1.3	0.3	1.2	0.2	0.3	0.3	1.0
Body fat percentage	0.3	1.3	2.5	-1.3	-0.6	-1.3	-1.2	0.2	-1.6
Number of full brothers	0.3	0.4	1.9	0.1	1.4	0.2	0.1	-0.5	0.4
Emphysema/chronic bronchitis	0.3	0.4	0.7	-0.6	0.4	-0.5	-0.4	-0.8	-0.8
Leg fat mass (right)	0.3	1.3	2.9	-1.1	-1.7	-1.2	-1.1	0.3	-1.0
Long-standing illness, disability or infirmity	0.3	0.4	1.2	0.8	0.0	0.6	0.6	-0.2	1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.6	-0.7	-0.3	-0.7	-0.7	0.0	-1.3
Osteoporosis (self-reported)	0.3	0.4	2.1	0.2	0.5	0.1	0.1	-1.4	0.5
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	0.7	0.9	0.4	0.6	0.3	1.0
Guilty feelings	0.3	0.5	1.5	0.1	-1.0	0.2	0.2	-1.2	-0.0
Hearing aid user	0.3	0.3	0.7	-0.5	-0.3	-0.5	-0.5	0.8	-0.7
Medication: Lisinopril	0.3	0.4	1.0	0.6	-0.2	0.5	0.6	-1.0	0.8
Number of operations (self-reported)	0.3	0.5	1.6	0.4	-1.3	0.4	0.4	-0.2	0.8
Leg fat mass (left)	0.3	1.3	2.7	-1.1	-1.6	-1.2	-1.1	0.1	-1.0
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.6	-0.4	-0.8	-0.8	-0.2	-0.3
Worry (Nagel 2018)	0.2	0.4	0.6	0.8	-0.3	0.6	0.7	0.4	0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.1	-0.7	-0.0	-0.1	-0.8	0.0
Crohns Disease (2012)	0.2	0.3	1.3	0.3	-1.1	0.1	0.2	-0.7	0.1
Primary Biliary Cirrhosis	0.2	0.2	0.8	-0.1	-0.9	-0.1	-0.0	-0.7	0.2
Triglycerides	0.2	0.3	0.9	0.4	-0.6	0.3	0.3	-0.9	0.1
Hair Pigment	0.2	5.6	10.9	2.7	-0.6	2.6	2.7	1.0	3.3
Sensitivity / hurt feelings	0.2	0.3	1.8	-0.3	0.1	-0.2	-0.3	-1.4	-0.1
Systolic blood pressure, automated reading	0.2	0.5	1.5	-0.5	1.2	-0.4	-0.5	-0.8	-0.5
Diabetes (mother)	0.2	0.3	1.0	-0.3	1.0	-0.2	-0.1	-0.3	-0.6
Age when periods started (menarche)	0.2	0.6	1.0	-0.9	-0.3	-1.0	-0.9	0.1	-1.0
Stomach or abdominal pain in last month	0.2	0.3	0.8	-0.1	-0.9	-0.1	-0.0	-0.8	-0.4
Forced vital capacity (FVC)	0.2	0.9	3.2	-0.7	-1.8	-0.5	-0.6	1.1	-0.2
Qualifications: None of the above	0.2	0.3	0.7	0.4	0.3	0.5	0.4	-0.8	0.8
Illnesses of siblings	0.2	0.2	0.7	-0.1	-0.7	-0.1	-0.1	0.8	-0.3
Neuroticism score	0.2	0.5	1.9	0.3	-1.4	0.2	0.2	-0.9	0.3
Falls in the last year	0.2	0.3	0.5	-0.4	-0.5	-0.7	-0.7	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.4	-0.6	-1.6	-0.4	-0.5	1.0	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	0.5	0.2	0.4	0.3	0.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.0	-0.1	0.1	-0.3	-0.3	-1.0	-0.4
Pulse wave peak to peak time	0.2	0.3	0.4	-0.5	-0.7	-0.2	-0.4	0.6	-0.6
Heart disease (mother)	0.2	0.3	1.0	-0.4	0.6	-0.2	-0.1	1.0	0.3
Number of full sisters	0.2	0.3	1.1	0.3	-1.1	0.5	0.5	0.2	0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.4	-0.3	-0.3	-0.4	-0.6	-0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.9	-0.2	0.9	-0.3	-0.3	-0.6	-0.1
Average weekly red wine intake	0.2	0.2	0.3	0.6	-0.5	0.5	0.5	-0.4	-0.2
Loneliness, isolation	0.2	0.3	1.4	0.2	-1.2	0.3	0.2	-0.7	0.1
Mineral and other dietary supplements	0.2	0.3	0.8	-0.3	0.4	-0.0	-0.0	0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.2	0.4	0.2	0.4	0.3	-1.1	0.9
Medication: Bendroflumethiazide	0.2	0.2	1.1	-0.2	1.1	-0.1	-0.2	-0.0	0.5
Risk taking	0.2	0.2	0.8	0.3	0.9	0.2	0.4	-0.4	0.3
Unable to work because of sickness or disability	0.2	0.2	1.1	-0.1	1.0	-0.3	-0.2	0.4	0.1
Crohns Disease (2017)	0.1	0.2	0.6	-0.4	-0.8	-0.5	-0.4	0.1	-0.4
Fasting Glucose	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.3	0.2
Lung FEV1/FVC ratio	0.1	0.7	2.0	-0.7	1.4	-0.6	-0.8	0.9	-0.6
Medication for hormone replacement therapy	0.1	0.2	0.7	0.3	-0.8	0.3	0.3	-0.1	-0.1
Vitamin and mineral supplements	0.1	0.2	0.3	-0.2	0.5	-0.3	-0.2	0.5	-0.5
Average weekly fortified wine intake	0.1	0.1	0.2	-0.3	-0.2	-0.3	-0.2	0.5	-0.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.6	-0.3	0.8	-0.1	-0.1	-0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.3	0.3	-1.1	0.5	0.3	-0.2	0.4
Mouth/teeth dental problems	0.1	0.1	0.2	0.3	-0.1	0.5	0.4	-0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.4	0.2	0.6	0.5	-0.3	0.1
Noisy workplace	0.1	0.1	0.5	0.3	-0.2	0.3	0.2	0.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	-0.3	-0.8	-0.1	-0.3	0.6	0.0
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.2	0.3	-0.1	0.1	-0.5	0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	0.2	-0.6	0.4	0.3	-0.1	0.2
Birth weight	0.1	0.1	0.6	0.1	0.2	0.1	0.1	0.8	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	1.6	-0.4	-1.3	-0.3	-0.4	0.3	0.1
Leg fat percentage (right)	0.1	0.2	0.4	-0.4	0.1	-0.6	-0.5	0.5	-0.6
Migraine (self-reported)	0.1	0.1	0.3	-0.3	0.5	-0.1	-0.2	-0.4	0.0
Overall health rating	0.1	0.3	0.4	0.6	-0.7	0.5	0.5	-0.2	0.6
Chest pain or discomfort	0.1	0.1	0.3	-0.3	0.5	-0.3	-0.3	0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.7	-0.1	0.9	-0.1	-0.0	-0.5	-0.2
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.5	-0.0	-0.6	-0.4	0.2	0.1
Leg fat percentage (left)	0.1	0.3	0.5	-0.6	-0.2	-0.7	-0.6	0.1	-0.7
Commuting to job workplace: Cycle	0.1	0.1	0.4	-0.2	-0.3	0.0	0.1	0.6	0.0
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.4	0.3	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.3	1.2	-0.4	0.2	-0.3	-0.4	-1.1	-0.5
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.0	0.3	-0.1
Worrier / anxious feelings	0.0	0.0	0.1	-0.1	0.3	-0.1	-0.2	0.2	0.2
Ever had bowel cancer screening	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.1	-0.0	-0.0

Hub : Genes

NR2F6

Models

Trait associations