[Hub]/) : Traits : Impedance of arm (right) : ←

chr22:40,117,397-43,232,818

Best TWAS P=1.31e-20 · Best GWAS P=2.75e-21 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
71	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ADSL	0.06	0.02	lasso	2	0.03	6.6e-03	9.3	9.3	1.3e-20	0.97	0.00	0.81	TRUE
46	YFS	Blood	TEF	0.09	0.17	lasso	2	0.17	9.0e-53	7.4	7.4	1.8e-13	0.11	0.01	0.99	TRUE
25	GTEx	Esophagus Gastroesophageal Junction	TOB2	0.16	0.01	enet	14	0.03	3.5e-02	-5.0	-7.1	1.1e-12	-0.16	0.06	0.15	TRUE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	MEI1	0.02	0.02	blup	69	0.01	1.5e-02	5.8	6.7	2.6e-11	0.12	0.03	0.80	TRUE
11	GTEx	Brain Cortex	POLR3H	0.27	0.21	lasso	8	0.18	8.5e-06	6.9	6.5	8.7e-11	0.11	0.10	0.88	TRUE
80	The Cancer Genome Atlas	Stomach Adenocarcinoma	ADSL	0.04	0.00	blup	33	0.03	2.6e-03	4.0	6.4	1.4e-10	0.68	0.02	0.72	TRUE
31	GTEx	Ovary	ACO2	0.14	0.12	lasso	3	0.13	4.5e-04	6.9	6.2	4.9e-10	0.06	0.06	0.81	TRUE
13	GTEx	Brain Frontal Cortex BA9	SLC25A17	0.11	-0.01	lasso	5	0.00	3.5e-01	5.2	6.0	2.0e-09	0.35	0.08	0.14	TRUE
37	GTEx	Thyroid	ZC3H7B	0.11	0.07	enet	7	0.07	3.9e-06	-5.0	-5.5	3.9e-08	-0.14	0.44	0.02	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EP300	0.05	0.00	bslmm	289	0.02	3.2e-03	-4.7	5.2	1.7e-07	0.16	0.46	0.02	TRUE
26	GTEx	Esophagus Mucosa	RANGAP1	0.07	0.02	lasso	4	0.02	8.6e-03	5.0	-5.2	1.8e-07	-0.18	0.20	0.29	TRUE
73	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADSL	0.09	0.03	lasso	3	0.01	7.7e-02	9.3	9.1	1.0e-19	0.92	0.00	0.75	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	TNRC6B	0.02	0.01	blup	92	0.01	2.7e-03	8.0	8.1	4.1e-16	0.85	0.01	0.84	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	ADSL	0.03	0.00	blup	33	0.01	8.9e-03	9.2	7.8	4.2e-15	0.84	0.01	0.54	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADSL	0.04	0.03	enet	6	0.03	1.6e-04	9.5	7.8	5.4e-15	0.90	0.00	0.96	FALSE
42	NTR	Blood	TEF	0.01	0.02	lasso	2	0.02	3.8e-06	7.2	7.3	2.6e-13	0.09	0.02	0.98	FALSE
79	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TEF	0.30	0.06	blup	36	0.09	1.8e-03	7.5	7.3	3.4e-13	0.14	0.01	0.81	FALSE
35	GTEx	Testis	TEF	0.06	0.05	lasso	5	0.04	5.5e-03	7.5	7.2	4.5e-13	0.08	0.03	0.92	FALSE
5	CommonMind	Brain Pre-frontal Cortex	TOB2	0.02	0.01	bslmm	278	0.01	3.5e-02	5.7	7.2	6.2e-13	0.11	0.23	0.59	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	MKL1	0.05	0.03	blup	105	0.04	3.9e-03	6.4	7.1	1.1e-12	0.38	0.03	0.45	FALSE
12	GTEx	Brain Cortex	CSDC2	0.31	0.32	lasso	5	0.28	1.8e-08	6.6	7.1	1.5e-12	0.13	0.39	0.61	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	PMM1	0.02	0.03	lasso	5	0.02	1.1e-03	7.0	-7.0	2.7e-12	-0.12	0.01	0.91	FALSE
52	The Cancer Genome Atlas	Colon Adenocarcinoma	TEF	0.04	0.03	blup	36	0.03	9.5e-03	6.5	7.0	2.9e-12	0.09	0.02	0.80	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CSDC2	0.20	0.30	lasso	5	0.32	2.1e-40	6.9	7.0	3.0e-12	0.11	0.30	0.70	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PMM1	0.04	0.03	lasso	6	0.02	6.1e-03	7.0	-7.0	3.0e-12	-0.12	0.01	0.78	FALSE
9	GTEx	Brain Cerebellar Hemisphere	POLR3H	0.10	0.08	lasso	7	0.08	4.9e-03	7.0	7.0	3.1e-12	0.12	0.09	0.58	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	CSDC2	0.25	0.28	lasso	2	0.29	1.8e-08	6.9	7.0	3.1e-12	0.13	0.21	0.78	FALSE
4	CommonMind	Brain Pre-frontal Cortex	POLR3H	0.24	0.31	enet	24	0.35	1.3e-44	6.4	6.9	4.2e-12	0.10	0.65	0.35	FALSE
14	GTEx	Brain Frontal Cortex BA9	POLR3H	0.13	0.09	lasso	7	0.04	3.4e-02	6.9	6.9	4.4e-12	0.12	0.06	0.71	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PMM1	0.02	0.02	blup	18	0.02	3.9e-03	6.6	-6.9	5.0e-12	-0.12	0.02	0.72	FALSE
45	YFS	Blood	NHP2L1	0.02	0.00	bslmm	300	0.01	1.6e-05	6.4	6.9	5.1e-12	0.12	0.06	0.93	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADSL	0.07	0.02	blup	33	0.05	5.2e-04	3.8	6.9	5.4e-12	0.68	0.07	0.51	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	MEI1	0.02	0.03	enet	2	0.02	2.3e-03	6.8	6.9	5.8e-12	0.13	0.02	0.88	FALSE
16	GTEx	Brain Hippocampus	POLR3H	0.16	0.11	lasso	14	0.05	2.4e-02	6.9	6.9	6.0e-12	0.12	0.08	0.62	FALSE
72	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PMM1	0.05	0.06	blup	18	0.06	4.1e-05	6.0	-6.9	6.4e-12	-0.12	0.02	0.98	FALSE
74	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PMM1	0.08	0.08	blup	23	0.09	1.1e-04	6.8	-6.9	6.7e-12	-0.12	0.03	0.94	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NHP2L1	0.08	0.09	bslmm	299	0.10	9.9e-12	6.7	-6.8	7.2e-12	-0.14	0.47	0.53	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	PMM1	0.20	0.16	lasso	7	0.14	1.9e-05	6.5	-6.8	7.2e-12	-0.12	0.46	0.46	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	PMM1	0.20	0.06	lasso	1	0.05	6.6e-04	6.8	-6.8	8.6e-12	-0.13	0.02	0.53	FALSE
44	YFS	Blood	MEI1	0.09	0.18	lasso	21	0.19	2.7e-59	6.8	6.8	1.1e-11	0.13	0.40	0.60	FALSE
83	The Cancer Genome Atlas	Stomach Adenocarcinoma	MKL1	0.05	0.01	blup	95	0.02	2.2e-02	-5.8	6.8	1.2e-11	0.47	0.11	0.26	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	TEF	0.23	0.13	lasso	7	0.16	6.9e-06	6.5	6.8	1.5e-11	0.11	0.11	0.88	FALSE
28	GTEx	Esophagus Muscularis	PMM1	0.07	0.05	lasso	5	0.05	6.8e-04	7.2	-6.7	2.8e-11	-0.11	0.11	0.87	FALSE
43	YFS	Blood	EP300	0.05	0.04	blup	284	0.05	5.2e-15	-4.7	6.7	2.8e-11	0.17	1.00	0.00	FALSE
15	GTEx	Brain Frontal Cortex BA9	CSDC2	0.25	0.23	lasso	8	0.24	3.8e-07	6.5	6.5	5.6e-11	0.10	0.07	0.92	FALSE
6	GTEx	Artery Aorta	ACO2	0.08	0.08	lasso	5	0.06	2.8e-04	6.5	6.5	6.3e-11	0.10	0.06	0.86	FALSE
19	GTEx	Brain Putamen basal ganglia	CSDC2	0.19	0.06	lasso	4	0.13	5.3e-04	6.7	6.5	6.7e-11	0.10	0.12	0.46	FALSE
34	GTEx	Testis	POLR3H	0.32	0.51	enet	9	0.51	5.6e-26	7.0	6.5	8.1e-11	0.11	0.19	0.81	FALSE
33	GTEx	Testis	CCDC134	0.20	0.29	lasso	20	0.26	4.9e-12	6.8	-6.5	9.7e-11	-0.12	0.40	0.60	FALSE
81	The Cancer Genome Atlas	Stomach Adenocarcinoma	C22orf46	0.02	0.03	blup	25	0.03	5.5e-03	6.8	-6.3	2.1e-10	-0.12	0.01	0.81	FALSE
24	GTEx	Cells Transformed fibroblasts	CSDC2	0.09	0.02	enet	18	0.06	3.6e-05	6.4	6.3	2.2e-10	0.03	0.21	0.68	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MEI1	0.04	0.05	blup	61	0.05	5.5e-06	5.8	6.3	2.3e-10	0.11	0.03	0.97	FALSE
40	GTEx	Vagina	PMM1	0.25	0.13	lasso	4	0.14	5.3e-04	6.9	-6.3	2.5e-10	-0.05	0.09	0.45	FALSE
39	GTEx	Uterus	ACO2	0.13	0.06	enet	31	0.08	9.5e-03	6.5	6.3	3.3e-10	0.12	0.10	0.61	FALSE
82	The Cancer Genome Atlas	Stomach Adenocarcinoma	MEI1	0.04	0.04	enet	4	0.03	2.5e-03	5.9	6.3	3.3e-10	0.11	0.03	0.90	FALSE
29	GTEx	Muscle Skeletal	PMM1	0.04	0.03	lasso	3	0.02	1.8e-03	6.7	-6.3	3.4e-10	-0.12	0.25	0.68	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLR3H	0.04	0.05	blup	27	0.05	3.4e-06	6.0	-6.3	3.7e-10	-0.08	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PMM1	0.02	0.01	blup	19	0.02	4.0e-03	5.9	-6.3	3.8e-10	-0.12	0.02	0.73	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	PMM1	0.09	0.11	blup	22	0.10	4.6e-10	5.9	-6.3	3.8e-10	-0.11	0.05	0.95	FALSE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MEI1	0.03	0.01	blup	64	0.02	3.8e-03	6.8	6.3	3.9e-10	0.13	0.02	0.86	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	MEI1	0.03	0.04	enet	8	0.03	1.0e-04	5.9	6.2	4.3e-10	0.09	0.04	0.96	FALSE
88	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PMM1	0.08	0.07	blup	24	0.05	1.8e-02	6.6	-6.2	4.8e-10	-0.11	0.02	0.51	FALSE
38	GTEx	Thyroid	ACO2	0.08	0.09	lasso	6	0.10	9.6e-08	5.7	6.2	7.0e-10	0.11	0.26	0.74	FALSE
62	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MEI1	0.06	0.04	blup	64	0.04	3.5e-03	5.9	6.1	1.1e-09	0.10	0.03	0.91	FALSE
32	GTEx	Stomach	DESI1	0.12	0.07	enet	14	0.06	4.9e-04	6.9	6.1	1.3e-09	0.12	0.17	0.80	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLR3H	0.04	0.04	blup	22	0.04	6.8e-05	6.0	-6.0	2.4e-09	-0.08	0.01	0.98	FALSE
84	The Cancer Genome Atlas	Stomach Adenocarcinoma	POLR3H	0.04	0.06	lasso	1	0.04	4.8e-04	6.0	-6.0	2.4e-09	-0.09	0.04	0.74	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WBP2NL	0.10	0.04	blup	140	0.05	1.8e-06	3.8	-5.9	2.9e-09	-0.03	0.98	0.00	FALSE
85	The Cancer Genome Atlas	Testicular Germ Cell Tumors	POLR3H	0.10	0.02	blup	23	0.06	3.4e-03	6.1	-5.9	3.3e-09	-0.12	0.01	0.80	FALSE
8	GTEx	Brain Caudate basal ganglia	CSDC2	0.13	0.03	enet	9	0.08	2.0e-03	2.4	5.9	4.0e-09	0.08	0.10	0.51	FALSE
18	GTEx	Brain Putamen basal ganglia	POLR3H	0.23	0.06	enet	20	0.04	4.5e-02	6.9	5.7	1.3e-08	0.12	0.06	0.47	FALSE
30	GTEx	Muscle Skeletal	MKL1	0.05	0.02	enet	26	0.03	4.2e-04	6.5	-5.6	1.8e-08	-0.28	0.68	0.04	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ACO2	0.03	0.01	blup	41	0.04	3.9e-03	-1.8	5.6	1.9e-08	0.11	0.02	0.52	FALSE
67	The Cancer Genome Atlas	Lung Adenocarcinoma	POLR3H	0.03	0.01	blup	26	0.01	6.4e-02	6.1	-5.6	2.3e-08	-0.07	0.01	0.87	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TNRC6B	0.12	0.05	lasso	4	0.05	4.2e-03	5.4	5.6	2.3e-08	0.51	0.03	0.64	FALSE
36	GTEx	Testis	RP5-821D11.7	0.15	0.16	lasso	8	0.12	9.0e-06	5.9	-5.5	3.6e-08	-0.11	0.36	0.64	FALSE
68	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PHF5A	0.03	0.00	blup	30	0.01	2.9e-02	6.5	5.5	3.9e-08	0.11	0.02	0.48	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	MEI1	0.01	0.01	blup	62	0.01	1.1e-02	5.9	5.5	5.0e-08	0.13	0.02	0.92	FALSE
7	GTEx	Artery Tibial	PMM1	0.04	0.04	lasso	4	0.02	1.8e-02	5.9	-5.4	5.4e-08	-0.03	0.15	0.63	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	L3MBTL2	0.12	0.08	lasso	6	0.05	1.0e-02	-4.8	-5.4	5.5e-08	-0.14	0.15	0.11	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TOB2	0.03	0.00	blup	28	0.02	3.4e-03	6.1	5.4	7.8e-08	0.11	0.01	0.58	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNRC6B	0.05	0.03	lasso	8	0.04	6.9e-06	4.1	5.3	1.2e-07	0.54	0.80	0.06	FALSE
53	The Cancer Genome Atlas	Glioblastoma Multiforme	MEI1	0.26	0.22	lasso	4	0.21	5.3e-07	5.9	5.2	1.6e-07	0.11	0.03	0.97	FALSE
41	NTR	Blood	EP300	0.04	0.00	bslmm	275	0.02	2.9e-06	-4.8	5.2	2.0e-07	0.08	0.47	0.05	FALSE
10	GTEx	Brain Cerebellar Hemisphere	CYP2D7P1	0.39	0.09	enet	12	0.20	7.2e-06	2.4	5.2	2.2e-07	0.04	0.54	0.03	FALSE
23	GTEx	Cells Transformed fibroblasts	PMM1	0.12	0.07	enet	15	0.11	1.0e-08	5.9	-5.2	2.4e-07	-0.08	0.75	0.25	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	NHP2L1	0.04	0.01	blup	28	0.02	2.3e-03	6.3	-5.2	2.5e-07	-0.07	0.02	0.77	FALSE
27	GTEx	Esophagus Mucosa	PMM1	0.05	0.00	enet	14	0.01	7.1e-02	6.4	-5.1	2.8e-07	-0.09	0.13	0.64	FALSE