[Hub]/) : Traits : Impedance of arm (left) : ←

chr22:40,117,397-42,917,154

Best TWAS P=1.03e-24 · Best GWAS P=4.06e-25 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CSDC2	0.20	0.30	lasso	5	0.32	2.1e-40	7.4	7.5	8.5e-14	0.11	0.34	0.66	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NHP2L1	0.08	0.09	bslmm	299	0.10	9.9e-12	7.3	-7.4	9.4e-14	-0.14	0.36	0.64	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR3H	0.24	0.31	enet	24	0.35	1.3e-44	6.8	7.2	7.7e-13	0.10	0.78	0.22	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TOB2	0.02	0.01	bslmm	278	0.01	3.5e-02	6.2	7.6	2.2e-14	0.11	0.21	0.63	FALSE
5	GTEx	Artery Aorta	ACO2	0.08	0.08	lasso	5	0.06	2.8e-04	6.9	7.0	2.2e-12	0.10	0.06	0.86	FALSE
6	GTEx	Artery Tibial	PMM1	0.04	0.04	lasso	4	0.02	1.8e-02	6.3	-5.8	6.2e-09	-0.03	0.14	0.65	TRUE
7	GTEx	Brain Caudate basal ganglia	CSDC2	0.13	0.03	enet	9	0.08	2.0e-03	2.8	6.3	2.3e-10	0.08	0.10	0.53	FALSE
8	GTEx	Brain Cerebellar Hemisphere	POLR3H	0.10	0.08	lasso	7	0.08	4.9e-03	7.3	7.3	2.0e-13	0.12	0.10	0.56	FALSE
9	GTEx	Brain Cortex	POLR3H	0.27	0.21	lasso	8	0.18	8.5e-06	7.3	6.9	4.3e-12	0.11	0.10	0.88	FALSE
10	GTEx	Brain Cortex	CSDC2	0.31	0.32	lasso	5	0.28	1.8e-08	7.2	7.5	4.9e-14	0.13	0.33	0.67	FALSE
11	GTEx	Brain Frontal Cortex BA9	SLC25A17	0.11	-0.01	lasso	5	0.00	3.5e-01	5.5	5.9	3.9e-09	0.35	0.08	0.14	FALSE
12	GTEx	Brain Frontal Cortex BA9	POLR3H	0.13	0.09	lasso	7	0.04	3.4e-02	7.3	7.3	2.6e-13	0.12	0.07	0.69	FALSE
13	GTEx	Brain Frontal Cortex BA9	CSDC2	0.25	0.23	lasso	8	0.24	3.8e-07	6.9	6.9	5.0e-12	0.10	0.07	0.92	FALSE
14	GTEx	Brain Hippocampus	POLR3H	0.16	0.11	lasso	14	0.05	2.4e-02	7.3	7.3	3.4e-13	0.12	0.08	0.61	TRUE
15	GTEx	Brain Nucleus accumbens basal ganglia	CSDC2	0.25	0.28	lasso	2	0.29	1.8e-08	7.3	7.4	1.2e-13	0.13	0.20	0.79	FALSE
16	GTEx	Brain Putamen basal ganglia	POLR3H	0.23	0.06	enet	20	0.04	4.5e-02	7.3	6.1	1.0e-09	0.12	0.06	0.49	FALSE
17	GTEx	Brain Putamen basal ganglia	CSDC2	0.19	0.06	lasso	4	0.13	5.3e-04	7.2	7.1	1.8e-12	0.10	0.11	0.50	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	L3MBTL2	0.12	0.08	lasso	6	0.05	1.0e-02	-4.5	-5.2	1.6e-07	-0.14	0.15	0.11	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	PMM1	0.20	0.16	lasso	7	0.14	1.9e-05	6.9	-7.3	3.1e-13	-0.12	0.42	0.51	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	TEF	0.23	0.13	lasso	7	0.16	6.9e-06	6.9	7.2	7.8e-13	0.11	0.10	0.89	FALSE
21	GTEx	Cells Transformed fibroblasts	PMM1	0.12	0.07	enet	15	0.11	1.0e-08	6.3	-5.6	2.3e-08	-0.08	0.68	0.32	FALSE
22	GTEx	Cells Transformed fibroblasts	CSDC2	0.09	0.02	enet	18	0.06	3.6e-05	6.8	6.4	1.7e-10	0.03	0.20	0.70	FALSE
23	GTEx	Colon Sigmoid	POLR3H	0.25	0.00	enet	20	0.02	9.1e-02	7.7	-5.5	4.7e-08	-0.01	0.06	0.31	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	TOB2	0.16	0.01	enet	14	0.03	3.5e-02	-5.1	-7.3	2.4e-13	-0.16	0.06	0.17	FALSE
25	GTEx	Esophagus Mucosa	RANGAP1	0.07	0.02	lasso	4	0.02	8.6e-03	5.6	-5.8	7.6e-09	-0.18	0.20	0.29	FALSE
26	GTEx	Esophagus Mucosa	PMM1	0.05	0.00	enet	14	0.01	7.1e-02	7.0	-5.5	3.0e-08	-0.09	0.13	0.65	FALSE
27	GTEx	Esophagus Muscularis	PMM1	0.07	0.05	lasso	5	0.05	6.8e-04	7.7	-7.1	1.2e-12	-0.11	0.10	0.89	FALSE
28	GTEx	Muscle Skeletal	PMM1	0.04	0.03	lasso	3	0.02	1.8e-03	7.3	-6.8	1.3e-11	-0.12	0.22	0.72	FALSE
29	GTEx	Muscle Skeletal	MKL1	0.05	0.02	enet	26	0.03	4.2e-04	7.1	-6.6	5.6e-11	-0.28	0.68	0.04	FALSE
30	GTEx	Nerve Tibial	ACO2	0.06	0.05	lasso	5	0.04	8.5e-04	6.9	5.5	3.3e-08	0.09	0.22	0.75	TRUE
31	GTEx	Ovary	ACO2	0.14	0.12	lasso	3	0.13	4.5e-04	7.3	6.5	7.3e-11	0.06	0.06	0.79	FALSE
32	GTEx	Skin Sun Exposed Lower leg	PMM1	0.04	0.00	lasso	4	0.02	1.4e-02	2.7	-5.4	7.9e-08	-0.10	0.11	0.44	FALSE
33	GTEx	Stomach	DESI1	0.12	0.07	enet	14	0.06	4.9e-04	7.3	6.6	4.8e-11	0.12	0.14	0.84	FALSE
34	GTEx	Testis	CCDC134	0.20	0.29	lasso	20	0.26	4.9e-12	7.3	-7.0	2.1e-12	-0.12	0.33	0.67	FALSE
35	GTEx	Testis	POLR3H	0.32	0.51	enet	9	0.51	5.6e-26	7.3	6.9	4.1e-12	0.11	0.31	0.69	FALSE
36	GTEx	Testis	PMM1	0.09	0.10	lasso	4	0.11	1.0e-05	4.0	-5.3	1.1e-07	-0.11	0.33	0.54	FALSE
37	GTEx	Testis	TEF	0.06	0.05	lasso	5	0.04	5.5e-03	7.9	7.7	1.1e-14	0.08	0.04	0.91	FALSE
38	GTEx	Testis	RP5-821D11.7	0.15	0.16	lasso	8	0.12	9.0e-06	6.3	-6.1	1.1e-09	-0.11	0.31	0.69	FALSE
39	GTEx	Thyroid	ZC3H7B	0.11	0.07	enet	7	0.07	3.9e-06	-5.1	-5.3	1.3e-07	-0.14	0.44	0.02	FALSE
40	GTEx	Thyroid	ACO2	0.08	0.09	lasso	6	0.10	9.6e-08	6.2	6.6	3.2e-11	0.11	0.23	0.77	FALSE
41	GTEx	Uterus	NHP2L1	0.15	0.06	lasso	6	0.06	2.7e-02	2.2	-5.9	4.3e-09	-0.09	0.06	0.41	FALSE
42	GTEx	Uterus	ACO2	0.13	0.06	enet	31	0.08	9.5e-03	6.9	6.9	5.9e-12	0.12	0.09	0.64	FALSE
43	GTEx	Vagina	PMM1	0.25	0.13	lasso	4	0.14	5.3e-04	7.4	-6.8	1.4e-11	-0.05	0.09	0.50	FALSE
44	NTR	Blood	EP300	0.04	0.00	bslmm	275	0.02	2.9e-06	-4.5	5.6	2.2e-08	0.08	0.47	0.04	FALSE
45	NTR	Blood	TEF	0.01	0.02	lasso	2	0.02	3.8e-06	7.7	7.8	5.0e-15	0.09	0.02	0.98	FALSE
46	YFS	Blood	EP300	0.05	0.04	blup	284	0.05	5.2e-15	-4.5	6.6	4.9e-11	0.17	1.00	0.00	FALSE
47	YFS	Blood	MEI1	0.09	0.18	lasso	21	0.19	2.7e-59	7.3	7.4	1.1e-13	0.13	0.36	0.64	FALSE
48	YFS	Blood	NHP2L1	0.02	0.00	bslmm	300	0.01	1.6e-05	6.9	7.1	1.4e-12	0.12	0.06	0.92	FALSE
49	YFS	Blood	TEF	0.09	0.17	lasso	2	0.17	9.0e-53	7.9	7.9	2.4e-15	0.11	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PMM1	0.04	0.03	lasso	6	0.02	6.1e-03	7.3	-7.4	1.9e-13	-0.12	0.01	0.76	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	MEI1	0.01	0.01	blup	62	0.01	1.1e-02	6.3	6.0	2.6e-09	0.13	0.02	0.93	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	TNRC6B	0.02	0.01	blup	92	0.01	2.7e-03	9.1	9.1	9.1e-20	0.85	0.01	0.85	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	MEI1	0.05	0.00	blup	64	0.03	1.1e-02	6.3	5.2	2.1e-07	0.13	0.02	0.54	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	MKL1	0.05	0.03	blup	105	0.04	3.9e-03	6.9	7.5	4.9e-14	0.38	0.03	0.47	TRUE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	PMM1	0.20	0.06	lasso	1	0.05	6.6e-04	7.3	-7.3	2.3e-13	-0.13	0.01	0.67	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	TEF	0.04	0.03	blup	36	0.03	9.5e-03	6.9	7.5	9.3e-14	0.09	0.02	0.78	FALSE
57	The Cancer Genome Atlas	Glioblastoma Multiforme	MEI1	0.26	0.22	lasso	4	0.21	5.3e-07	6.3	5.8	8.2e-09	0.11	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MEI1	0.03	0.01	blup	64	0.02	3.8e-03	7.4	6.7	1.5e-11	0.13	0.02	0.86	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PMM1	0.02	0.02	blup	18	0.02	3.9e-03	7.2	-7.3	2.4e-13	-0.12	0.01	0.74	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLR3H	0.04	0.04	blup	22	0.04	6.8e-05	6.4	-6.4	1.5e-10	-0.08	0.01	0.98	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADSL	0.04	0.03	enet	6	0.03	1.6e-04	10.4	8.2	2.0e-16	0.90	0.00	0.96	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MEI1	0.04	0.05	blup	61	0.05	5.5e-06	6.2	6.8	7.6e-12	0.11	0.03	0.97	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WBP2NL	0.10	0.04	blup	140	0.05	1.8e-06	3.3	-5.6	1.6e-08	-0.03	0.98	0.00	TRUE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ACO2	0.03	0.01	blup	41	0.04	3.9e-03	-2.4	6.2	5.4e-10	0.11	0.02	0.52	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADSL	0.07	0.02	blup	33	0.05	5.2e-04	4.0	7.4	1.2e-13	0.68	0.07	0.51	FALSE
66	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MEI1	0.06	0.04	blup	64	0.04	3.5e-03	6.3	6.5	6.0e-11	0.10	0.03	0.91	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	MEI1	0.08	0.08	blup	60	0.08	6.9e-10	6.3	5.3	1.1e-07	0.11	0.07	0.93	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNRC6B	0.05	0.03	lasso	8	0.04	6.9e-06	4.4	5.5	3.0e-08	0.54	0.80	0.06	FALSE
69	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MEI1	0.06	0.05	blup	62	0.08	2.0e-04	6.9	5.7	1.3e-08	0.10	0.04	0.82	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	ADSL	0.03	0.00	blup	33	0.01	8.9e-03	10.1	8.3	8.2e-17	0.84	0.01	0.55	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	MEI1	0.03	0.04	enet	8	0.03	1.0e-04	6.3	6.6	3.6e-11	0.09	0.04	0.95	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	PMM1	0.02	0.03	lasso	5	0.02	1.1e-03	7.4	-7.4	1.8e-13	-0.12	0.01	0.90	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	POLR3H	0.03	0.01	blup	26	0.01	6.4e-02	6.5	-5.9	3.6e-09	-0.07	0.01	0.87	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PHF5A	0.03	0.00	blup	30	0.01	2.9e-02	6.9	6.0	1.9e-09	0.11	0.02	0.48	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PMM1	0.02	0.01	blup	19	0.02	4.0e-03	6.2	-6.8	1.4e-11	-0.12	0.01	0.75	FALSE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TOB2	0.03	0.00	blup	28	0.02	3.4e-03	6.6	6.0	2.4e-09	0.11	0.01	0.58	FALSE
77	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ADSL	0.06	0.02	lasso	2	0.03	6.6e-03	10.2	10.3	1.0e-24	0.97	0.00	0.81	TRUE
78	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PMM1	0.05	0.06	blup	18	0.06	4.1e-05	6.4	-7.3	3.2e-13	-0.12	0.02	0.98	FALSE
79	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADSL	0.09	0.03	lasso	3	0.01	7.7e-02	10.1	10.0	2.2e-23	0.92	0.00	0.75	FALSE
80	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PMM1	0.08	0.08	blup	23	0.09	1.1e-04	7.3	-7.3	2.7e-13	-0.12	0.02	0.95	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TNRC6B	0.12	0.05	lasso	4	0.05	4.2e-03	5.9	6.5	6.5e-11	0.51	0.03	0.64	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	MEI1	0.02	0.02	blup	69	0.01	1.5e-02	6.3	7.1	1.6e-12	0.12	0.03	0.81	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	NHP2L1	0.04	0.01	blup	28	0.02	2.3e-03	6.8	-5.5	4.2e-08	-0.07	0.02	0.77	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLR3H	0.04	0.05	blup	27	0.05	3.4e-06	6.4	-6.4	1.6e-10	-0.08	0.02	0.98	TRUE
85	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TEF	0.30	0.06	blup	36	0.09	1.8e-03	7.9	7.9	2.0e-15	0.14	0.01	0.79	TRUE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	ADSL	0.04	0.00	blup	33	0.03	2.6e-03	4.2	6.7	1.7e-11	0.68	0.02	0.71	FALSE
87	The Cancer Genome Atlas	Stomach Adenocarcinoma	C22orf46	0.02	0.03	blup	25	0.03	5.5e-03	7.3	-6.8	7.6e-12	-0.12	0.01	0.81	FALSE
88	The Cancer Genome Atlas	Stomach Adenocarcinoma	MEI1	0.04	0.04	enet	4	0.03	2.5e-03	6.3	6.8	1.4e-11	0.11	0.03	0.90	FALSE
89	The Cancer Genome Atlas	Stomach Adenocarcinoma	MKL1	0.05	0.01	blup	95	0.02	2.2e-02	-5.5	6.8	1.4e-11	0.47	0.11	0.24	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	POLR3H	0.04	0.06	lasso	1	0.04	4.8e-04	6.4	-6.4	1.4e-10	-0.09	0.04	0.74	FALSE
91	The Cancer Genome Atlas	Testicular Germ Cell Tumors	POLR3H	0.10	0.02	blup	23	0.06	3.4e-03	6.5	-6.4	1.4e-10	-0.12	0.01	0.80	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	L3MBTL2	0.05	0.03	enet	9	0.04	1.8e-04	3.7	5.2	2.3e-07	0.14	0.01	0.97	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	MEI1	0.02	0.03	enet	2	0.02	2.3e-03	7.4	7.4	1.1e-13	0.13	0.02	0.88	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	PMM1	0.09	0.11	blup	22	0.10	4.6e-10	6.2	-6.6	3.2e-11	-0.11	0.03	0.97	FALSE
95	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PMM1	0.08	0.07	blup	24	0.05	1.8e-02	7.2	-6.7	2.7e-11	-0.11	0.01	0.56	FALSE