[Hub]/) : Traits : Impedance of arm (left) :

chr22:40,117,397-42,917,154

Best TWAS P=1.03e-24 · Best GWAS P=4.06e-25 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CSDC2 0.20 0.30 lasso 5 0.32 2.1e-40 7.4 7.5 8.5e-14 0.11 0.34 0.66 FALSE
2 CommonMind Brain Pre-frontal Cortex NHP2L1 0.08 0.09 bslmm 299 0.10 9.9e-12 7.3 -7.4 9.4e-14 -0.14 0.36 0.64 FALSE
3 CommonMind Brain Pre-frontal Cortex POLR3H 0.24 0.31 enet 24 0.35 1.3e-44 6.8 7.2 7.7e-13 0.10 0.78 0.22 FALSE
4 CommonMind Brain Pre-frontal Cortex TOB2 0.02 0.01 bslmm 278 0.01 3.5e-02 6.2 7.6 2.2e-14 0.11 0.21 0.63 FALSE
5 GTEx Artery Aorta ACO2 0.08 0.08 lasso 5 0.06 2.8e-04 6.9 7.0 2.2e-12 0.10 0.06 0.86 FALSE
6 GTEx Artery Tibial PMM1 0.04 0.04 lasso 4 0.02 1.8e-02 6.3 -5.8 6.2e-09 -0.03 0.14 0.65 TRUE
7 GTEx Brain Caudate basal ganglia CSDC2 0.13 0.03 enet 9 0.08 2.0e-03 2.8 6.3 2.3e-10 0.08 0.10 0.53 FALSE
8 GTEx Brain Cerebellar Hemisphere POLR3H 0.10 0.08 lasso 7 0.08 4.9e-03 7.3 7.3 2.0e-13 0.12 0.10 0.56 FALSE
9 GTEx Brain Cortex POLR3H 0.27 0.21 lasso 8 0.18 8.5e-06 7.3 6.9 4.3e-12 0.11 0.10 0.88 FALSE
10 GTEx Brain Cortex CSDC2 0.31 0.32 lasso 5 0.28 1.8e-08 7.2 7.5 4.9e-14 0.13 0.33 0.67 FALSE
11 GTEx Brain Frontal Cortex BA9 SLC25A17 0.11 -0.01 lasso 5 0.00 3.5e-01 5.5 5.9 3.9e-09 0.35 0.08 0.14 FALSE
12 GTEx Brain Frontal Cortex BA9 POLR3H 0.13 0.09 lasso 7 0.04 3.4e-02 7.3 7.3 2.6e-13 0.12 0.07 0.69 FALSE
13 GTEx Brain Frontal Cortex BA9 CSDC2 0.25 0.23 lasso 8 0.24 3.8e-07 6.9 6.9 5.0e-12 0.10 0.07 0.92 FALSE
14 GTEx Brain Hippocampus POLR3H 0.16 0.11 lasso 14 0.05 2.4e-02 7.3 7.3 3.4e-13 0.12 0.08 0.61 TRUE
15 GTEx Brain Nucleus accumbens basal ganglia CSDC2 0.25 0.28 lasso 2 0.29 1.8e-08 7.3 7.4 1.2e-13 0.13 0.20 0.79 FALSE
16 GTEx Brain Putamen basal ganglia POLR3H 0.23 0.06 enet 20 0.04 4.5e-02 7.3 6.1 1.0e-09 0.12 0.06 0.49 FALSE
17 GTEx Brain Putamen basal ganglia CSDC2 0.19 0.06 lasso 4 0.13 5.3e-04 7.2 7.1 1.8e-12 0.10 0.11 0.50 FALSE
18 GTEx Cells EBV-transformed lymphocytes L3MBTL2 0.12 0.08 lasso 6 0.05 1.0e-02 -4.5 -5.2 1.6e-07 -0.14 0.15 0.11 FALSE
19 GTEx Cells EBV-transformed lymphocytes PMM1 0.20 0.16 lasso 7 0.14 1.9e-05 6.9 -7.3 3.1e-13 -0.12 0.42 0.51 FALSE
20 GTEx Cells EBV-transformed lymphocytes TEF 0.23 0.13 lasso 7 0.16 6.9e-06 6.9 7.2 7.8e-13 0.11 0.10 0.89 FALSE
21 GTEx Cells Transformed fibroblasts PMM1 0.12 0.07 enet 15 0.11 1.0e-08 6.3 -5.6 2.3e-08 -0.08 0.68 0.32 FALSE
22 GTEx Cells Transformed fibroblasts CSDC2 0.09 0.02 enet 18 0.06 3.6e-05 6.8 6.4 1.7e-10 0.03 0.20 0.70 FALSE
23 GTEx Colon Sigmoid POLR3H 0.25 0.00 enet 20 0.02 9.1e-02 7.7 -5.5 4.7e-08 -0.01 0.06 0.31 FALSE
24 GTEx Esophagus Gastroesophageal Junction TOB2 0.16 0.01 enet 14 0.03 3.5e-02 -5.1 -7.3 2.4e-13 -0.16 0.06 0.17 FALSE
25 GTEx Esophagus Mucosa RANGAP1 0.07 0.02 lasso 4 0.02 8.6e-03 5.6 -5.8 7.6e-09 -0.18 0.20 0.29 FALSE
26 GTEx Esophagus Mucosa PMM1 0.05 0.00 enet 14 0.01 7.1e-02 7.0 -5.5 3.0e-08 -0.09 0.13 0.65 FALSE
27 GTEx Esophagus Muscularis PMM1 0.07 0.05 lasso 5 0.05 6.8e-04 7.7 -7.1 1.2e-12 -0.11 0.10 0.89 FALSE
28 GTEx Muscle Skeletal PMM1 0.04 0.03 lasso 3 0.02 1.8e-03 7.3 -6.8 1.3e-11 -0.12 0.22 0.72 FALSE
29 GTEx Muscle Skeletal MKL1 0.05 0.02 enet 26 0.03 4.2e-04 7.1 -6.6 5.6e-11 -0.28 0.68 0.04 FALSE
30 GTEx Nerve Tibial ACO2 0.06 0.05 lasso 5 0.04 8.5e-04 6.9 5.5 3.3e-08 0.09 0.22 0.75 TRUE
31 GTEx Ovary ACO2 0.14 0.12 lasso 3 0.13 4.5e-04 7.3 6.5 7.3e-11 0.06 0.06 0.79 FALSE
32 GTEx Skin Sun Exposed Lower leg PMM1 0.04 0.00 lasso 4 0.02 1.4e-02 2.7 -5.4 7.9e-08 -0.10 0.11 0.44 FALSE
33 GTEx Stomach DESI1 0.12 0.07 enet 14 0.06 4.9e-04 7.3 6.6 4.8e-11 0.12 0.14 0.84 FALSE
34 GTEx Testis CCDC134 0.20 0.29 lasso 20 0.26 4.9e-12 7.3 -7.0 2.1e-12 -0.12 0.33 0.67 FALSE
35 GTEx Testis POLR3H 0.32 0.51 enet 9 0.51 5.6e-26 7.3 6.9 4.1e-12 0.11 0.31 0.69 FALSE
36 GTEx Testis PMM1 0.09 0.10 lasso 4 0.11 1.0e-05 4.0 -5.3 1.1e-07 -0.11 0.33 0.54 FALSE
37 GTEx Testis TEF 0.06 0.05 lasso 5 0.04 5.5e-03 7.9 7.7 1.1e-14 0.08 0.04 0.91 FALSE
38 GTEx Testis RP5-821D11.7 0.15 0.16 lasso 8 0.12 9.0e-06 6.3 -6.1 1.1e-09 -0.11 0.31 0.69 FALSE
39 GTEx Thyroid ZC3H7B 0.11 0.07 enet 7 0.07 3.9e-06 -5.1 -5.3 1.3e-07 -0.14 0.44 0.02 FALSE
40 GTEx Thyroid ACO2 0.08 0.09 lasso 6 0.10 9.6e-08 6.2 6.6 3.2e-11 0.11 0.23 0.77 FALSE
41 GTEx Uterus NHP2L1 0.15 0.06 lasso 6 0.06 2.7e-02 2.2 -5.9 4.3e-09 -0.09 0.06 0.41 FALSE
42 GTEx Uterus ACO2 0.13 0.06 enet 31 0.08 9.5e-03 6.9 6.9 5.9e-12 0.12 0.09 0.64 FALSE
43 GTEx Vagina PMM1 0.25 0.13 lasso 4 0.14 5.3e-04 7.4 -6.8 1.4e-11 -0.05 0.09 0.50 FALSE
44 NTR Blood EP300 0.04 0.00 bslmm 275 0.02 2.9e-06 -4.5 5.6 2.2e-08 0.08 0.47 0.04 FALSE
45 NTR Blood TEF 0.01 0.02 lasso 2 0.02 3.8e-06 7.7 7.8 5.0e-15 0.09 0.02 0.98 FALSE
46 YFS Blood EP300 0.05 0.04 blup 284 0.05 5.2e-15 -4.5 6.6 4.9e-11 0.17 1.00 0.00 FALSE
47 YFS Blood MEI1 0.09 0.18 lasso 21 0.19 2.7e-59 7.3 7.4 1.1e-13 0.13 0.36 0.64 FALSE
48 YFS Blood NHP2L1 0.02 0.00 bslmm 300 0.01 1.6e-05 6.9 7.1 1.4e-12 0.12 0.06 0.92 FALSE
49 YFS Blood TEF 0.09 0.17 lasso 2 0.17 9.0e-53 7.9 7.9 2.4e-15 0.11 0.00 1.00 FALSE
50 The Cancer Genome Atlas Bladder Urothelial Carcinoma PMM1 0.04 0.03 lasso 6 0.02 6.1e-03 7.3 -7.4 1.9e-13 -0.12 0.01 0.76 FALSE
51 The Cancer Genome Atlas Breast Invasive Carcinoma MEI1 0.01 0.01 blup 62 0.01 1.1e-02 6.3 6.0 2.6e-09 0.13 0.02 0.93 FALSE
52 The Cancer Genome Atlas Breast Invasive Carcinoma TNRC6B 0.02 0.01 blup 92 0.01 2.7e-03 9.1 9.1 9.1e-20 0.85 0.01 0.85 FALSE
53 The Cancer Genome Atlas Colon Adenocarcinoma MEI1 0.05 0.00 blup 64 0.03 1.1e-02 6.3 5.2 2.1e-07 0.13 0.02 0.54 FALSE
54 The Cancer Genome Atlas Colon Adenocarcinoma MKL1 0.05 0.03 blup 105 0.04 3.9e-03 6.9 7.5 4.9e-14 0.38 0.03 0.47 TRUE
55 The Cancer Genome Atlas Colon Adenocarcinoma PMM1 0.20 0.06 lasso 1 0.05 6.6e-04 7.3 -7.3 2.3e-13 -0.13 0.01 0.67 FALSE
56 The Cancer Genome Atlas Colon Adenocarcinoma TEF 0.04 0.03 blup 36 0.03 9.5e-03 6.9 7.5 9.3e-14 0.09 0.02 0.78 FALSE
57 The Cancer Genome Atlas Glioblastoma Multiforme MEI1 0.26 0.22 lasso 4 0.21 5.3e-07 6.3 5.8 8.2e-09 0.11 0.03 0.97 FALSE
58 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MEI1 0.03 0.01 blup 64 0.02 3.8e-03 7.4 6.7 1.5e-11 0.13 0.02 0.86 FALSE
59 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PMM1 0.02 0.02 blup 18 0.02 3.9e-03 7.2 -7.3 2.4e-13 -0.12 0.01 0.74 FALSE
60 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma POLR3H 0.04 0.04 blup 22 0.04 6.8e-05 6.4 -6.4 1.5e-10 -0.08 0.01 0.98 FALSE
61 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADSL 0.04 0.03 enet 6 0.03 1.6e-04 10.4 8.2 2.0e-16 0.90 0.00 0.96 FALSE
62 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MEI1 0.04 0.05 blup 61 0.05 5.5e-06 6.2 6.8 7.6e-12 0.11 0.03 0.97 FALSE
63 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WBP2NL 0.10 0.04 blup 140 0.05 1.8e-06 3.3 -5.6 1.6e-08 -0.03 0.98 0.00 TRUE
64 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ACO2 0.03 0.01 blup 41 0.04 3.9e-03 -2.4 6.2 5.4e-10 0.11 0.02 0.52 FALSE
65 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ADSL 0.07 0.02 blup 33 0.05 5.2e-04 4.0 7.4 1.2e-13 0.68 0.07 0.51 FALSE
66 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MEI1 0.06 0.04 blup 64 0.04 3.5e-03 6.3 6.5 6.0e-11 0.10 0.03 0.91 FALSE
67 The Cancer Genome Atlas Brain Lower Grade Glioma MEI1 0.08 0.08 blup 60 0.08 6.9e-10 6.3 5.3 1.1e-07 0.11 0.07 0.93 FALSE
68 The Cancer Genome Atlas Brain Lower Grade Glioma TNRC6B 0.05 0.03 lasso 8 0.04 6.9e-06 4.4 5.5 3.0e-08 0.54 0.80 0.06 FALSE
69 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MEI1 0.06 0.05 blup 62 0.08 2.0e-04 6.9 5.7 1.3e-08 0.10 0.04 0.82 FALSE
70 The Cancer Genome Atlas Lung Adenocarcinoma ADSL 0.03 0.00 blup 33 0.01 8.9e-03 10.1 8.3 8.2e-17 0.84 0.01 0.55 FALSE
71 The Cancer Genome Atlas Lung Adenocarcinoma MEI1 0.03 0.04 enet 8 0.03 1.0e-04 6.3 6.6 3.6e-11 0.09 0.04 0.95 FALSE
72 The Cancer Genome Atlas Lung Adenocarcinoma PMM1 0.02 0.03 lasso 5 0.02 1.1e-03 7.4 -7.4 1.8e-13 -0.12 0.01 0.90 FALSE
73 The Cancer Genome Atlas Lung Adenocarcinoma POLR3H 0.03 0.01 blup 26 0.01 6.4e-02 6.5 -5.9 3.6e-09 -0.07 0.01 0.87 FALSE
74 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PHF5A 0.03 0.00 blup 30 0.01 2.9e-02 6.9 6.0 1.9e-09 0.11 0.02 0.48 FALSE
75 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PMM1 0.02 0.01 blup 19 0.02 4.0e-03 6.2 -6.8 1.4e-11 -0.12 0.01 0.75 FALSE
76 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TOB2 0.03 0.00 blup 28 0.02 3.4e-03 6.6 6.0 2.4e-09 0.11 0.01 0.58 FALSE
77 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ADSL 0.06 0.02 lasso 2 0.03 6.6e-03 10.2 10.3 1.0e-24 0.97 0.00 0.81 TRUE
78 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PMM1 0.05 0.06 blup 18 0.06 4.1e-05 6.4 -7.3 3.2e-13 -0.12 0.02 0.98 FALSE
79 The Cancer Genome Atlas Pancreatic Adenocarcinoma ADSL 0.09 0.03 lasso 3 0.01 7.7e-02 10.1 10.0 2.2e-23 0.92 0.00 0.75 FALSE
80 The Cancer Genome Atlas Pancreatic Adenocarcinoma PMM1 0.08 0.08 blup 23 0.09 1.1e-04 7.3 -7.3 2.7e-13 -0.12 0.02 0.95 FALSE
81 The Cancer Genome Atlas Pancreatic Adenocarcinoma TNRC6B 0.12 0.05 lasso 4 0.05 4.2e-03 5.9 6.5 6.5e-11 0.51 0.03 0.64 FALSE
82 The Cancer Genome Atlas Prostate Adenocarcinoma MEI1 0.02 0.02 blup 69 0.01 1.5e-02 6.3 7.1 1.6e-12 0.12 0.03 0.81 FALSE
83 The Cancer Genome Atlas Prostate Adenocarcinoma NHP2L1 0.04 0.01 blup 28 0.02 2.3e-03 6.8 -5.5 4.2e-08 -0.07 0.02 0.77 FALSE
84 The Cancer Genome Atlas Prostate Adenocarcinoma POLR3H 0.04 0.05 blup 27 0.05 3.4e-06 6.4 -6.4 1.6e-10 -0.08 0.02 0.98 TRUE
85 The Cancer Genome Atlas Skin Cutaneous Melanoma TEF 0.30 0.06 blup 36 0.09 1.8e-03 7.9 7.9 2.0e-15 0.14 0.01 0.79 TRUE
86 The Cancer Genome Atlas Stomach Adenocarcinoma ADSL 0.04 0.00 blup 33 0.03 2.6e-03 4.2 6.7 1.7e-11 0.68 0.02 0.71 FALSE
87 The Cancer Genome Atlas Stomach Adenocarcinoma C22orf46 0.02 0.03 blup 25 0.03 5.5e-03 7.3 -6.8 7.6e-12 -0.12 0.01 0.81 FALSE
88 The Cancer Genome Atlas Stomach Adenocarcinoma MEI1 0.04 0.04 enet 4 0.03 2.5e-03 6.3 6.8 1.4e-11 0.11 0.03 0.90 FALSE
89 The Cancer Genome Atlas Stomach Adenocarcinoma MKL1 0.05 0.01 blup 95 0.02 2.2e-02 -5.5 6.8 1.4e-11 0.47 0.11 0.24 FALSE
90 The Cancer Genome Atlas Stomach Adenocarcinoma POLR3H 0.04 0.06 lasso 1 0.04 4.8e-04 6.4 -6.4 1.4e-10 -0.09 0.04 0.74 FALSE
91 The Cancer Genome Atlas Testicular Germ Cell Tumors POLR3H 0.10 0.02 blup 23 0.06 3.4e-03 6.5 -6.4 1.4e-10 -0.12 0.01 0.80 FALSE
92 The Cancer Genome Atlas Thyroid Carcinoma L3MBTL2 0.05 0.03 enet 9 0.04 1.8e-04 3.7 5.2 2.3e-07 0.14 0.01 0.97 FALSE
93 The Cancer Genome Atlas Thyroid Carcinoma MEI1 0.02 0.03 enet 2 0.02 2.3e-03 7.4 7.4 1.1e-13 0.13 0.02 0.88 FALSE
94 The Cancer Genome Atlas Thyroid Carcinoma PMM1 0.09 0.11 blup 22 0.10 4.6e-10 6.2 -6.6 3.2e-11 -0.11 0.03 0.97 FALSE
95 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma PMM1 0.08 0.07 blup 24 0.05 1.8e-02 7.2 -6.7 2.7e-11 -0.11 0.01 0.56 FALSE