Best TWAS P=4.29e-13 · Best GWAS P=1.14e-25 conditioned to 3.73e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PNKP | 0.15 | 0.16 | enet | 23 | 0.16 | 7.0e-19 | -5.3 | -5.4 | 5.4e-08 | 0.03 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | SAE1 | 0.21 | 0.09 | lasso | 3 | 0.07 | 2.0e-03 | -5.2 | -6.9 | 7.1e-12 | 0.77 | 0.06 | 0.67 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | TBC1D17 | 0.11 | 0.03 | enet | 23 | 0.04 | 6.5e-04 | -4.8 | 6.0 | 1.9e-09 | -0.02 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Colon Sigmoid | PRR12 | 0.20 | 0.01 | lasso | 8 | 0.00 | 4.9e-01 | 3.1 | 5.5 | 4.8e-08 | 0.02 | 0.04 | 0.32 | FALSE |
| 5 | GTEx | Esophagus Mucosa | AP2A1 | 0.18 | 0.09 | enet | 8 | 0.13 | 7.7e-09 | -4.9 | -6.3 | 3.2e-10 | -0.01 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Muscle Skeletal | AKT1S1 | 0.10 | 0.09 | lasso | 3 | 0.08 | 1.9e-08 | -5.1 | 5.1 | 2.8e-07 | -0.05 | 0.06 | 0.94 | FALSE |
| 7 | GTEx | Nerve Tibial | AP2A1 | 0.16 | 0.05 | lasso | 4 | 0.07 | 1.3e-05 | -5.1 | -6.4 | 1.9e-10 | 0.02 | 0.01 | 0.98 | TRUE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | RASIP1 | 0.15 | 0.04 | lasso | 6 | 0.08 | 2.9e-05 | -4.7 | -5.6 | 2.5e-08 | 0.03 | 0.38 | 0.36 | TRUE |
| 9 | GTEx | Skin Sun Exposed Lower leg | CCDC9 | 0.13 | 0.00 | lasso | 5 | 0.00 | 2.2e-01 | 2.2 | -5.6 | 2.3e-08 | 0.23 | 0.11 | 0.21 | TRUE |
| 10 | GTEx | Skin Sun Exposed Lower leg | NTN5 | 0.11 | 0.09 | enet | 18 | 0.05 | 6.2e-05 | -3.6 | -5.2 | 1.5e-07 | 0.02 | 0.79 | 0.17 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | AP2A1 | 0.15 | 0.08 | enet | 10 | 0.07 | 1.9e-06 | -5.1 | -5.2 | 1.9e-07 | -0.01 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Spleen | PPFIA3 | 0.25 | 0.23 | lasso | 4 | 0.21 | 3.9e-06 | 4.6 | -5.5 | 3.1e-08 | -0.01 | 0.23 | 0.49 | FALSE |
| 13 | GTEx | Stomach | VRK3 | 0.10 | -0.01 | enet | 10 | -0.01 | 7.3e-01 | 3.9 | 5.9 | 2.8e-09 | 0.00 | 0.04 | 0.43 | FALSE |
| 14 | GTEx | Testis | NTN5 | 0.16 | 0.02 | enet | 23 | 0.06 | 9.6e-04 | -3.5 | -6.1 | 1.1e-09 | -0.02 | 0.03 | 0.76 | FALSE |
| 15 | METSIM | Adipose | SAE1 | 0.12 | 0.04 | lasso | 5 | 0.07 | 1.7e-10 | -5.2 | -7.2 | 4.3e-13 | 0.61 | 0.61 | 0.39 | TRUE |
| 16 | YFS | Blood | SAE1 | 0.07 | 0.02 | enet | 18 | 0.05 | 3.6e-16 | -8.5 | -6.2 | 4.2e-10 | 0.56 | 0.99 | 0.01 | FALSE |
| 17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FUT2 | 0.05 | 0.01 | blup | 52 | 0.01 | 6.1e-02 | -4.9 | 5.2 | 1.7e-07 | 0.01 | 0.02 | 0.52 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LIN7B | 0.02 | 0.00 | enet | 7 | 0.02 | 5.1e-05 | 4.9 | -6.0 | 2.7e-09 | -0.04 | 0.01 | 0.90 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NTN5 | 0.02 | 0.01 | enet | 11 | 0.01 | 7.6e-04 | -3.8 | -5.4 | 5.7e-08 | 0.00 | 0.04 | 0.73 | FALSE |
| 20 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNRNP70 | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.9e-02 | 5.2 | -6.3 | 3.7e-10 | -0.02 | 0.01 | 0.76 | TRUE |
| 21 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FUT2 | 0.10 | 0.01 | blup | 51 | 0.05 | 9.8e-04 | -3.4 | 5.2 | 2.0e-07 | -0.02 | 0.03 | 0.81 | FALSE |
| 22 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GRLF1 | 0.04 | 0.04 | blup | 51 | 0.03 | 7.0e-05 | 4.3 | 5.4 | 6.0e-08 | -0.04 | 0.44 | 0.08 | TRUE |