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chr17:60,821,100-64,251,733

Best TWAS P=9.31e-31 · Best GWAS P=3.95e-28 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	-10.60	11.5	9.3e-31	0.49	0.25	0.75	TRUE
83	The Cancer Genome Atlas	Thyroid Carcinoma	PLEKHM1P	0.04	0.03	blup	7	0.05	1.2e-05	8.45	-9.1	1.4e-19	-0.04	0.01	0.99	TRUE
13	GTEx	Brain Hypothalamus	DDX42	0.15	0.18	lasso	3	0.09	4.2e-03	10.65	-8.6	7.3e-18	-0.90	0.06	0.62	TRUE
61	YFS	Blood	SMARCD2	0.03	0.04	lasso	7	0.05	7.6e-15	11.00	8.1	6.0e-16	0.94	0.03	0.97	TRUE
26	GTEx	Esophagus Mucosa	CCDC47	0.12	0.00	lasso	5	0.00	3.7e-01	10.71	5.8	4.8e-09	0.72	0.06	0.47	TRUE
12	GTEx	Brain Hippocampus	CYB561	0.33	0.24	enet	29	0.27	4.3e-07	-2.54	5.6	2.7e-08	0.30	0.58	0.05	TRUE
43	GTEx	Skin Not Sun Exposed Suprapubic	DDX42	0.17	0.10	lasso	9	0.10	2.4e-06	-0.97	-5.5	3.5e-08	-0.80	0.10	0.90	TRUE
58	YFS	Blood	AXIN2	0.20	0.05	enet	34	0.10	5.1e-31	5.31	-5.4	6.7e-08	0.01	0.01	0.99	TRUE
8	GTEx	Artery Aorta	CYB561	0.07	0.04	enet	21	0.06	4.7e-04	-2.56	5.2	1.5e-07	0.27	0.14	0.13	TRUE
51	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	11.00	-11.0	6.0e-28	-0.99	0.02	0.98	FALSE
31	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	10.84	10.8	2.1e-27	0.98	0.04	0.95	FALSE
37	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	10.82	10.8	2.7e-27	0.98	0.03	0.97	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	10.85	10.8	3.4e-27	0.99	0.02	0.98	FALSE
15	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	10.85	10.8	3.8e-27	0.98	0.03	0.97	FALSE
49	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	10.82	10.7	6.5e-27	0.97	0.03	0.94	FALSE
19	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	10.70	10.7	1.0e-26	0.99	0.03	0.49	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	10.71	-10.7	1.0e-26	-0.99	0.04	0.89	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	10.82	-10.5	5.3e-26	-0.82	0.03	0.84	FALSE
34	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	10.53	10.5	5.3e-26	0.97	0.03	0.97	FALSE
46	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	10.85	10.5	6.1e-26	0.98	0.03	0.97	FALSE
5	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	10.73	10.5	8.8e-26	0.99	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	-10.58	10.5	1.3e-25	0.34	0.00	0.87	FALSE
11	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	9.90	10.4	2.2e-25	0.92	0.06	0.94	FALSE
57	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	10.01	-10.2	1.8e-24	-0.84	0.29	0.70	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	10.53	10.1	4.9e-24	0.98	0.02	0.74	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	10.85	10.0	1.3e-23	0.79	0.05	0.94	FALSE
60	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	9.72	-10.0	2.4e-23	-0.84	0.26	0.74	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCN4A	0.04	0.01	blup	39	0.03	1.4e-07	-10.58	-9.9	3.0e-23	-0.31	0.01	0.98	FALSE
40	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	10.85	9.8	9.7e-23	0.89	0.03	0.80	FALSE
42	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	10.70	9.8	1.1e-22	0.97	0.05	0.64	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	11.00	9.8	1.3e-22	0.98	0.00	1.00	FALSE
18	GTEx	Breast Mammary Tissue (Female)	DCAF7	0.10	0.02	lasso	3	0.00	4.4e-01	9.72	9.7	2.4e-22	0.93	0.04	0.50	FALSE
17	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	-9.88	9.6	9.3e-22	0.39	0.04	0.18	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	-9.45	-9.4	3.5e-21	-0.42	0.16	0.03	FALSE
45	GTEx	Skin Sun Exposed Lower leg	DDX42	0.07	0.04	lasso	4	0.05	2.5e-05	11.00	-9.4	7.7e-21	-0.98	0.02	0.98	FALSE
27	GTEx	Esophagus Mucosa	DDX42	0.08	0.06	lasso	3	0.09	1.3e-06	10.84	-9.3	1.0e-20	-0.95	0.03	0.97	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	SMARCD2	0.04	0.02	blup	28	0.01	1.6e-02	10.71	9.3	1.5e-20	0.97	0.00	0.78	FALSE
39	GTEx	Pancreas	DDX42	0.17	0.18	lasso	3	0.16	3.6e-07	10.70	-9.2	4.5e-20	-0.96	0.04	0.96	FALSE
28	GTEx	Esophagus Mucosa	MAP3K3	0.05	0.01	enet	11	0.02	1.8e-02	7.39	9.2	5.0e-20	0.79	0.04	0.86	FALSE
29	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	-9.19	-9.1	7.4e-20	-0.41	0.31	0.04	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	-9.09	-9.1	1.0e-19	-0.42	0.04	0.07	FALSE
30	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	-9.61	-9.1	1.2e-19	-0.34	0.53	0.02	FALSE
6	GTEx	Adipose Visceral Omentum	CD79B	0.15	0.00	lasso	6	0.02	4.1e-02	-10.60	9.0	1.7e-19	0.29	0.11	0.24	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLEKHM1P	0.02	0.02	blup	7	0.02	6.7e-03	8.38	-8.8	1.4e-18	-0.02	0.00	0.82	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SMARCD2	0.03	0.03	blup	330	0.03	1.1e-04	10.65	8.8	1.7e-18	0.92	0.04	0.95	FALSE
7	GTEx	Adipose Visceral Omentum	MAP3K3	0.10	0.04	enet	12	0.05	9.0e-04	10.82	8.8	1.7e-18	0.84	0.02	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PLEKHM1P	0.24	0.26	lasso	6	0.27	8.0e-33	8.45	-8.7	2.7e-18	-0.02	0.01	0.99	FALSE
10	GTEx	Artery Tibial	DDX42	0.13	0.14	lasso	5	0.15	9.1e-12	10.82	-8.7	4.3e-18	-0.94	0.02	0.98	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX42	0.07	0.07	enet	11	0.07	9.2e-08	10.68	-8.6	1.1e-17	-0.94	0.03	0.97	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	PLEKHM1P	0.08	0.04	blup	7	0.04	2.7e-02	8.48	-8.5	1.4e-17	-0.01	0.00	0.41	FALSE
16	GTEx	Breast Mammary Tissue (Male)	MAP3K3	0.12	0.14	lasso	2	0.07	1.2e-02	10.53	8.5	1.8e-17	0.93	0.04	0.78	FALSE
23	GTEx	Cells Transformed fibroblasts	SMURF2	0.17	0.13	enet	8	0.13	3.7e-10	8.00	8.5	2.7e-17	0.04	0.04	0.96	FALSE
21	GTEx	Cells Transformed fibroblasts	PSMC5	0.19	0.09	lasso	5	0.10	7.1e-08	-9.09	-8.4	3.8e-17	-0.40	0.96	0.01	FALSE
47	GTEx	Skin Sun Exposed Lower leg	hsa-mir-6080	0.11	0.10	lasso	2	0.08	1.7e-07	8.03	-8.4	4.7e-17	-0.01	0.06	0.94	FALSE
56	NTR	Blood	LIMD2	0.04	0.03	blup	304	0.03	2.2e-10	10.01	-8.2	3.3e-16	-0.82	0.05	0.95	FALSE
75	The Cancer Genome Atlas	Lung Adenocarcinoma	PLEKHM1P	0.02	0.01	blup	7	0.02	4.7e-03	8.38	-8.2	3.4e-16	0.00	0.00	0.73	FALSE
24	GTEx	Colon Sigmoid	CD79B	0.17	0.00	lasso	9	0.08	9.7e-04	10.72	8.1	7.0e-16	0.68	0.04	0.66	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	-9.09	8.1	7.6e-16	0.24	0.03	0.04	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLEKHM1P	0.08	0.03	enet	4	0.04	4.0e-05	8.45	-7.9	2.7e-15	-0.04	0.01	0.94	FALSE
54	METSIM	Adipose	CD79B	0.04	0.01	lasso	5	0.01	4.3e-03	-4.82	7.7	1.2e-14	0.43	0.22	0.25	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DDX42	0.04	0.02	blup	51	0.03	3.9e-04	11.00	-7.7	1.9e-14	-0.92	0.01	0.97	FALSE
32	GTEx	Esophagus Muscularis	MAP3K3	0.07	0.02	enet	8	0.02	3.0e-02	10.67	7.3	2.7e-13	0.87	0.05	0.90	FALSE
48	GTEx	Spleen	FTSJ3	0.19	0.07	lasso	3	0.06	1.2e-02	9.81	7.2	4.3e-13	0.87	0.11	0.71	FALSE
33	GTEx	Heart Atrial Appendage	CYB561	0.19	0.01	enet	28	0.06	1.3e-03	-1.98	7.2	5.2e-13	0.41	0.07	0.12	FALSE
36	GTEx	Muscle Skeletal	SMARCD2	0.13	0.03	lasso	5	0.04	1.3e-04	-9.11	-7.1	9.5e-13	-0.21	0.84	0.01	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SCN4A	0.05	0.01	blup	41	0.04	2.2e-05	3.34	-7.1	1.2e-12	0.08	0.03	0.88	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRADA	0.07	0.01	blup	57	0.03	5.5e-04	1.78	6.8	8.3e-12	0.13	0.10	0.03	FALSE
25	GTEx	Colon Transverse	DDX42	0.19	0.07	lasso	4	0.11	4.4e-06	-1.94	-6.5	7.4e-11	-0.77	0.09	0.89	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	PLEKHM1P	0.01	0.01	enet	7	0.01	1.9e-02	8.38	-6.4	1.9e-10	0.01	0.01	0.72	FALSE
50	GTEx	Stomach	DCAF7	0.24	0.00	enet	33	0.08	1.2e-04	0.69	6.3	3.4e-10	0.40	0.04	0.50	FALSE
59	YFS	Blood	ICAM2	0.06	0.03	enet	21	0.04	1.3e-11	3.10	-6.3	3.5e-10	-0.14	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Stomach Adenocarcinoma	DDX42	0.04	0.02	blup	51	0.04	5.2e-04	10.73	-6.2	4.2e-10	-0.84	0.02	0.79	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	DDX42	0.06	0.04	blup	51	0.06	7.9e-08	-1.01	-6.2	4.3e-10	-0.83	0.08	0.92	FALSE
53	GTEx	Vagina	SMURF2	0.32	0.00	enet	1	0.06	1.4e-02	6.12	6.1	9.5e-10	0.09	0.03	0.21	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SMURF2	0.10	0.01	blup	14	0.05	5.5e-03	6.89	5.9	3.7e-09	0.00	0.00	0.80	FALSE
55	METSIM	Adipose	RP11-214C8.2	0.03	0.00	blup	304	0.01	4.2e-03	-2.85	-5.8	5.1e-09	-0.16	0.25	0.03	FALSE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC5	0.13	0.06	blup	27	0.07	7.2e-05	-0.83	5.6	2.5e-08	0.80	0.23	0.44	FALSE
52	GTEx	Testis	CCDC47	0.17	0.06	enet	28	0.09	1.0e-04	-9.45	5.5	2.9e-08	0.13	0.49	0.19	FALSE
41	GTEx	Pancreas	MILR1	0.18	0.01	lasso	7	0.03	1.3e-02	8.09	5.5	4.2e-08	0.04	0.08	0.06	FALSE
22	GTEx	Cells Transformed fibroblasts	ICAM2	0.17	0.06	lasso	5	0.09	5.6e-07	3.25	-5.4	5.9e-08	-0.11	0.94	0.00	FALSE
35	GTEx	Muscle Skeletal	PSMC5	0.04	0.02	lasso	2	0.02	3.1e-03	7.49	5.4	7.0e-08	0.77	0.14	0.71	FALSE
38	GTEx	Pancreas	FTSJ3	0.19	0.28	enet	44	0.31	1.7e-13	-0.99	5.3	1.2e-07	0.78	0.92	0.08	FALSE
9	GTEx	Artery Aorta	CCDC47	0.08	0.02	lasso	2	0.01	9.4e-02	-0.93	5.3	1.4e-07	0.79	0.06	0.65	FALSE